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Database: PDB
Entry: 6GEN
LinkDB: 6GEN
Original site: 6GEN 
HEADER    NUCLEAR PROTEIN                         27-APR-18   6GEN              
TITLE     CHROMATIN REMODELLER-NUCLEOSOME COMPLEX AT 4.5 A RESOLUTION.          
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 72;            
COMPND   3 CHAIN: Z;                                                            
COMPND   4 ENGINEERED: YES;                                                     
COMPND   5 MOL_ID: 2;                                                           
COMPND   6 MOLECULE: HISTONE H3;                                                
COMPND   7 CHAIN: A, B;                                                         
COMPND   8 ENGINEERED: YES;                                                     
COMPND   9 MOL_ID: 3;                                                           
COMPND  10 MOLECULE: HISTONE H4;                                                
COMPND  11 CHAIN: C, D;                                                         
COMPND  12 ENGINEERED: YES;                                                     
COMPND  13 MOL_ID: 4;                                                           
COMPND  14 MOLECULE: HISTONE H2A.1;                                             
COMPND  15 CHAIN: E, F;                                                         
COMPND  16 ENGINEERED: YES;                                                     
COMPND  17 MOL_ID: 5;                                                           
COMPND  18 MOLECULE: HISTONE H2B.1;                                             
COMPND  19 CHAIN: G, H;                                                         
COMPND  20 SYNONYM: SUPPRESSOR OF TY PROTEIN 12;                                
COMPND  21 ENGINEERED: YES;                                                     
COMPND  22 MOL_ID: 6;                                                           
COMPND  23 MOLECULE: DNA (173-MER);                                             
COMPND  24 CHAIN: I;                                                            
COMPND  25 ENGINEERED: YES;                                                     
COMPND  26 MOL_ID: 7;                                                           
COMPND  27 MOLECULE: DNA (173-MER);                                             
COMPND  28 CHAIN: J;                                                            
COMPND  29 ENGINEERED: YES;                                                     
COMPND  30 MOL_ID: 8;                                                           
COMPND  31 MOLECULE: HELICASE SWR1;                                             
COMPND  32 CHAIN: M;                                                            
COMPND  33 SYNONYM: SWI2/SNF2-RELATED 1;                                        
COMPND  34 EC: 3.6.4.12;                                                        
COMPND  35 ENGINEERED: YES;                                                     
COMPND  36 MOL_ID: 9;                                                           
COMPND  37 MOLECULE: ACTIN-LIKE PROTEIN ARP6;                                   
COMPND  38 CHAIN: R;                                                            
COMPND  39 ENGINEERED: YES;                                                     
COMPND  40 MOL_ID: 10;                                                          
COMPND  41 MOLECULE: VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 71;            
COMPND  42 CHAIN: S;                                                            
COMPND  43 SYNONYM: SWR COMPLEX PROTEIN 6;                                      
COMPND  44 ENGINEERED: YES;                                                     
COMPND  45 MOL_ID: 11;                                                          
COMPND  46 MOLECULE: RUVB-LIKE PROTEIN 1;                                       
COMPND  47 CHAIN: T, V, X;                                                      
COMPND  48 SYNONYM: RUVBL1,TIP49-HOMOLOGY PROTEIN 1,TIP49A HOMOLOG;             
COMPND  49 EC: 3.6.4.12;                                                        
COMPND  50 ENGINEERED: YES;                                                     
COMPND  51 MOL_ID: 12;                                                          
COMPND  52 MOLECULE: RUVB-LIKE PROTEIN 2;                                       
COMPND  53 CHAIN: U, W, Y;                                                      
COMPND  54 SYNONYM: RUVBL2,TIP49-HOMOLOGY PROTEIN 2,TIP49B HOMOLOG;             
COMPND  55 EC: 3.6.4.12;                                                        
COMPND  56 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE (STRAIN ATCC 204508 /  
SOURCE   3 S288C);                                                              
SOURCE   4 ORGANISM_TAXID: 559292;                                              
SOURCE   5 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;                                  
SOURCE   6 EXPRESSION_SYSTEM_TAXID: 7111;                                       
SOURCE   7 MOL_ID: 2;                                                           
SOURCE   8 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE (STRAIN ATCC 204508 /  
SOURCE   9 S288C);                                                              
SOURCE  10 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  11 ORGANISM_TAXID: 559292;                                              
SOURCE  12 GENE: HHT1, YBR010W, YBR0201, HHT2, SIN2, YNL031C, N2749;            
SOURCE  13 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  14 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE  15 MOL_ID: 3;                                                           
SOURCE  16 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE (STRAIN ATCC 204508 /  
SOURCE  17 S288C);                                                              
SOURCE  18 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  19 ORGANISM_TAXID: 559292;                                              
SOURCE  20 GENE: HHF1, YBR009C, YBR0122, HHF2, YNL030W, N2752;                  
SOURCE  21 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  22 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE  23 MOL_ID: 4;                                                           
SOURCE  24 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE (STRAIN ATCC 204508 /  
SOURCE  25 S288C);                                                              
SOURCE  26 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  27 ORGANISM_TAXID: 559292;                                              
SOURCE  28 GENE: HTA1, H2A1, SPT11, YDR225W, YD9934.10;                         
SOURCE  29 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  30 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE  31 MOL_ID: 5;                                                           
SOURCE  32 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE (STRAIN ATCC 204508 /  
SOURCE  33 S288C);                                                              
SOURCE  34 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  35 ORGANISM_TAXID: 559292;                                              
SOURCE  36 GENE: HTB1, H2B1, SPT12, YDR224C, YD9934.09C;                        
SOURCE  37 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  38 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE  39 MOL_ID: 6;                                                           
SOURCE  40 ORGANISM_SCIENTIFIC: SYNTHETIC CONSTRUCT;                            
SOURCE  41 ORGANISM_TAXID: 32630;                                               
SOURCE  42 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  43 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE  44 MOL_ID: 7;                                                           
SOURCE  45 ORGANISM_SCIENTIFIC: SYNTHETIC CONSTRUCT;                            
SOURCE  46 ORGANISM_TAXID: 32630;                                               
SOURCE  47 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  48 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE  49 MOL_ID: 8;                                                           
SOURCE  50 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE (STRAIN ATCC 204508 /  
SOURCE  51 S288C);                                                              
SOURCE  52 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  53 ORGANISM_TAXID: 559292;                                              
SOURCE  54 GENE: SWR1, YDR334W, D9651.6;                                        
SOURCE  55 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;                                  
SOURCE  56 EXPRESSION_SYSTEM_TAXID: 7111;                                       
SOURCE  57 MOL_ID: 9;                                                           
SOURCE  58 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE (STRAIN ATCC 204508 /  
SOURCE  59 S288C);                                                              
SOURCE  60 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  61 ORGANISM_TAXID: 559292;                                              
SOURCE  62 GENE: ARP6, YLR085C, L2393, L9449.13;                                
SOURCE  63 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;                                  
SOURCE  64 EXPRESSION_SYSTEM_TAXID: 7111;                                       
SOURCE  65 MOL_ID: 10;                                                          
SOURCE  66 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE (STRAIN ATCC 204508 /  
SOURCE  67 S288C);                                                              
SOURCE  68 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  69 ORGANISM_TAXID: 559292;                                              
SOURCE  70 GENE: VPS71, SWC6, YML041C, YM8054.02C;                              
SOURCE  71 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;                                  
SOURCE  72 EXPRESSION_SYSTEM_TAXID: 7111;                                       
SOURCE  73 MOL_ID: 11;                                                          
SOURCE  74 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE (STRAIN ATCC 204508 /  
SOURCE  75 S288C);                                                              
SOURCE  76 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  77 ORGANISM_TAXID: 559292;                                              
SOURCE  78 GENE: RVB1, TIH1, TIP49A, YDR190C;                                   
SOURCE  79 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;                                  
SOURCE  80 EXPRESSION_SYSTEM_TAXID: 7111;                                       
SOURCE  81 MOL_ID: 12;                                                          
SOURCE  82 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE (STRAIN ATCC 204508 /  
SOURCE  83 S288C);                                                              
SOURCE  84 ORGANISM_COMMON: BAKER'S YEAST;                                      
SOURCE  85 ORGANISM_TAXID: 559292;                                              
SOURCE  86 GENE: RVB2, TIH2, TIP49B, YPL235W, P1060;                            
SOURCE  87 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;                                  
SOURCE  88 EXPRESSION_SYSTEM_TAXID: 7111                                        
KEYWDS    CHROMATIN, REMODELLER, ATPASE, HISTONE, NUCLEAR PROTEIN               
EXPDTA    ELECTRON MICROSCOPY                                                   
AUTHOR    O.WILLHOFT,E.Y.D.CHUA,M.WILKINSON,D.B.WIGLEY                          
REVDAT   3   18-DEC-19 6GEN    1       SCALE                                    
REVDAT   2   24-OCT-18 6GEN    1       JRNL                                     
REVDAT   1   17-OCT-18 6GEN    0                                                
JRNL        AUTH   O.WILLHOFT,M.GHONEIM,C.L.LIN,E.Y.D.CHUA,M.WILKINSON,         
JRNL        AUTH 2 Y.CHABAN,R.AYALA,E.A.MCCORMACK,L.OCLOO,D.S.RUEDA,D.B.WIGLEY  
JRNL        TITL   STRUCTURE AND DYNAMICS OF THE YEAST SWR1-NUCLEOSOME COMPLEX. 
JRNL        REF    SCIENCE                       V. 362       2018              
JRNL        REFN                   ESSN 1095-9203                               
JRNL        PMID   30309918                                                     
JRNL        DOI    10.1126/SCIENCE.AAT7716                                      
REMARK   2                                                                      
REMARK   2 RESOLUTION.    3.60 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   SOFTWARE PACKAGES      : GCTF, CRYOSPARC, RELION, RELION, RELION   
REMARK   3   RECONSTRUCTION SCHEMA  : NULL                                      
REMARK   3                                                                      
REMARK   3 EM MAP-MODEL FITTING AND REFINEMENT                                  
REMARK   3   PDB ENTRY                    : NULL                                
REMARK   3   REFINEMENT SPACE             : NULL                                
REMARK   3   REFINEMENT PROTOCOL          : NULL                                
REMARK   3   REFINEMENT TARGET            : NULL                                
REMARK   3   OVERALL ANISOTROPIC B VALUE  : NULL                                
REMARK   3                                                                      
REMARK   3 FITTING PROCEDURE : NULL                                             
REMARK   3                                                                      
REMARK   3 EM IMAGE RECONSTRUCTION STATISTICS                                   
REMARK   3   NOMINAL PIXEL SIZE (ANGSTROMS)    : NULL                           
REMARK   3   ACTUAL PIXEL SIZE  (ANGSTROMS)    : NULL                           
REMARK   3   EFFECTIVE RESOLUTION (ANGSTROMS)  : 3.600                          
REMARK   3   NUMBER OF PARTICLES               : 98529                          
REMARK   3   CTF CORRECTION METHOD             : PHASE FLIPPING AND AMPLITUDE   
REMARK   3                                       CORRECTION                     
REMARK   3                                                                      
REMARK   3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL                    
REMARK   3                                                                      
REMARK   3 OTHER DETAILS: NULL                                                  
REMARK   4                                                                      
REMARK   4 6GEN COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 27-APR-18.                  
REMARK 100 THE DEPOSITION ID IS D_1200009847.                                   
REMARK 245                                                                      
REMARK 245 EXPERIMENTAL DETAILS                                                 
REMARK 245   RECONSTRUCTION METHOD          : SINGLE PARTICLE                   
REMARK 245   SPECIMEN TYPE                  : NULL                              
REMARK 245                                                                      
REMARK 245 ELECTRON MICROSCOPE SAMPLE                                           
REMARK 245   SAMPLE TYPE                    : PARTICLE                          
REMARK 245   PARTICLE TYPE                  : POINT                             
REMARK 245   NAME OF SAMPLE                 : SWR1-NUCLEOSOME COMPLEX;          
REMARK 245                                    HISTONES; DNA; REMODELLER         
REMARK 245   SAMPLE CONCENTRATION (MG ML-1) : 0.03                              
REMARK 245   SAMPLE SUPPORT DETAILS         : NULL                              
REMARK 245   SAMPLE VITRIFICATION DETAILS   : NULL                              
REMARK 245   SAMPLE BUFFER                  : NULL                              
REMARK 245   PH                             : 7.00                              
REMARK 245   SAMPLE DETAILS                 : NULL                              
REMARK 245                                                                      
REMARK 245 DATA ACQUISITION                                                     
REMARK 245   DATE OF EXPERIMENT                : NULL                           
REMARK 245   NUMBER OF MICROGRAPHS-IMAGES      : 5517                           
REMARK 245   TEMPERATURE (KELVIN)              : NULL                           
REMARK 245   MICROSCOPE MODEL                  : FEI TITAN KRIOS                
REMARK 245   DETECTOR TYPE                     : FEI FALCON III (4K X 4K)       
REMARK 245   MINIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MAXIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MINIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   MAXIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   NOMINAL CS                        : NULL                           
REMARK 245   IMAGING MODE                      : BRIGHT FIELD                   
REMARK 245   ELECTRON DOSE (ELECTRONS NM**-2)  : 1.72                           
REMARK 245   ILLUMINATION MODE                 : OTHER                          
REMARK 245   NOMINAL MAGNIFICATION             : NULL                           
REMARK 245   CALIBRATED MAGNIFICATION          : NULL                           
REMARK 245   SOURCE                            : FIELD EMISSION GUN             
REMARK 245   ACCELERATION VOLTAGE (KV)         : 300                            
REMARK 245   IMAGING DETAILS                   : NULL                           
REMARK 247                                                                      
REMARK 247 ELECTRON MICROSCOPY                                                  
REMARK 247  THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON          
REMARK 247  MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE              
REMARK 247  THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES           
REMARK 247  ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION         
REMARK 247  OF THE STRUCTURE FACTORS.                                           
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: EICOSAMERIC                       
REMARK 350 APPLY THE FOLLOWING TO CHAINS: Z, A, B, C, D, E, F, G, H, I,         
REMARK 350                    AND CHAINS: J, M, R, S, T, U, V, W, X, Y          
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     MET A     0                                                      
REMARK 465     ALA A     1                                                      
REMARK 465     ARG A     2                                                      
REMARK 465     THR A     3                                                      
REMARK 465     LYS A     4                                                      
REMARK 465     GLN A     5                                                      
REMARK 465     THR A     6                                                      
REMARK 465     ALA A     7                                                      
REMARK 465     ARG A     8                                                      
REMARK 465     LYS A     9                                                      
REMARK 465     SER A    10                                                      
REMARK 465     THR A    11                                                      
REMARK 465     GLY A    12                                                      
REMARK 465     GLY A    13                                                      
REMARK 465     LYS A    14                                                      
REMARK 465     ALA A    15                                                      
REMARK 465     PRO A    16                                                      
REMARK 465     ARG A    17                                                      
REMARK 465     LYS A    18                                                      
REMARK 465     GLN A    19                                                      
REMARK 465     LEU A    20                                                      
REMARK 465     ALA A    21                                                      
REMARK 465     SER A    22                                                      
REMARK 465     LYS A    23                                                      
REMARK 465     ALA A    24                                                      
REMARK 465     ALA A    25                                                      
REMARK 465     ARG A    26                                                      
REMARK 465     LYS A    27                                                      
REMARK 465     SER A    28                                                      
REMARK 465     ALA A    29                                                      
REMARK 465     PRO A    30                                                      
REMARK 465     SER A    31                                                      
REMARK 465     THR A    32                                                      
REMARK 465     GLY A    33                                                      
REMARK 465     GLY A    34                                                      
REMARK 465     VAL A    35                                                      
REMARK 465     LYS A    36                                                      
REMARK 465     ARG A   134                                                      
REMARK 465     SER A   135                                                      
REMARK 465     MET B     0                                                      
REMARK 465     ALA B     1                                                      
REMARK 465     ARG B     2                                                      
REMARK 465     THR B     3                                                      
REMARK 465     LYS B     4                                                      
REMARK 465     GLN B     5                                                      
REMARK 465     THR B     6                                                      
REMARK 465     ALA B     7                                                      
REMARK 465     ARG B     8                                                      
REMARK 465     LYS B     9                                                      
REMARK 465     SER B    10                                                      
REMARK 465     THR B    11                                                      
REMARK 465     GLY B    12                                                      
REMARK 465     GLY B    13                                                      
REMARK 465     LYS B    14                                                      
REMARK 465     ALA B    15                                                      
REMARK 465     PRO B    16                                                      
REMARK 465     ARG B    17                                                      
REMARK 465     LYS B    18                                                      
REMARK 465     GLN B    19                                                      
REMARK 465     LEU B    20                                                      
REMARK 465     ALA B    21                                                      
REMARK 465     SER B    22                                                      
REMARK 465     LYS B    23                                                      
REMARK 465     ALA B    24                                                      
REMARK 465     ALA B    25                                                      
REMARK 465     ARG B    26                                                      
REMARK 465     LYS B    27                                                      
REMARK 465     SER B    28                                                      
REMARK 465     ALA B    29                                                      
REMARK 465     PRO B    30                                                      
REMARK 465     SER B    31                                                      
REMARK 465     THR B    32                                                      
REMARK 465     GLY B    33                                                      
REMARK 465     GLY B    34                                                      
REMARK 465     VAL B    35                                                      
REMARK 465     LYS B    36                                                      
REMARK 465     ARG B   134                                                      
REMARK 465     SER B   135                                                      
REMARK 465     MET C     0                                                      
REMARK 465     SER C     1                                                      
REMARK 465     GLY C     2                                                      
REMARK 465     ARG C     3                                                      
REMARK 465     GLY C     4                                                      
REMARK 465     LYS C     5                                                      
REMARK 465     GLY C     6                                                      
REMARK 465     GLY C     7                                                      
REMARK 465     LYS C     8                                                      
REMARK 465     GLY C     9                                                      
REMARK 465     LEU C    10                                                      
REMARK 465     GLY C    11                                                      
REMARK 465     LYS C    12                                                      
REMARK 465     GLY C    13                                                      
REMARK 465     GLY C    14                                                      
REMARK 465     ALA C    15                                                      
REMARK 465     LYS C    16                                                      
REMARK 465     ARG C    17                                                      
REMARK 465     HIS C    18                                                      
REMARK 465     ARG C    19                                                      
REMARK 465     LYS C    20                                                      
REMARK 465     MET D     0                                                      
REMARK 465     SER D     1                                                      
REMARK 465     GLY D     2                                                      
REMARK 465     ARG D     3                                                      
REMARK 465     GLY D     4                                                      
REMARK 465     LYS D     5                                                      
REMARK 465     GLY D     6                                                      
REMARK 465     GLY D     7                                                      
REMARK 465     LYS D     8                                                      
REMARK 465     GLY D     9                                                      
REMARK 465     LEU D    10                                                      
REMARK 465     GLY D    11                                                      
REMARK 465     LYS D    12                                                      
REMARK 465     GLY D    13                                                      
REMARK 465     GLY D    14                                                      
REMARK 465     ALA D    15                                                      
REMARK 465     LYS D    16                                                      
REMARK 465     ARG D    17                                                      
REMARK 465     HIS D    18                                                      
REMARK 465     ARG D    19                                                      
REMARK 465     LYS D    20                                                      
REMARK 465     ILE D    21                                                      
REMARK 465     LEU D    22                                                      
REMARK 465     MET E     0                                                      
REMARK 465     SER E     1                                                      
REMARK 465     GLY E     2                                                      
REMARK 465     GLY E     3                                                      
REMARK 465     LYS E     4                                                      
REMARK 465     GLY E     5                                                      
REMARK 465     GLY E     6                                                      
REMARK 465     LYS E     7                                                      
REMARK 465     ALA E     8                                                      
REMARK 465     GLY E     9                                                      
REMARK 465     SER E    10                                                      
REMARK 465     ALA E    11                                                      
REMARK 465     ALA E    12                                                      
REMARK 465     LYS E    13                                                      
REMARK 465     ALA E    14                                                      
REMARK 465     SER E    15                                                      
REMARK 465     LYS E   119                                                      
REMARK 465     LYS E   120                                                      
REMARK 465     SER E   121                                                      
REMARK 465     ALA E   122                                                      
REMARK 465     LYS E   123                                                      
REMARK 465     ALA E   124                                                      
REMARK 465     THR E   125                                                      
REMARK 465     LYS E   126                                                      
REMARK 465     ALA E   127                                                      
REMARK 465     SER E   128                                                      
REMARK 465     GLN E   129                                                      
REMARK 465     GLU E   130                                                      
REMARK 465     LEU E   131                                                      
REMARK 465     MET F     0                                                      
REMARK 465     SER F     1                                                      
REMARK 465     GLY F     2                                                      
REMARK 465     GLY F     3                                                      
REMARK 465     LYS F     4                                                      
REMARK 465     GLY F     5                                                      
REMARK 465     GLY F     6                                                      
REMARK 465     LYS F     7                                                      
REMARK 465     ALA F     8                                                      
REMARK 465     GLY F     9                                                      
REMARK 465     SER F    10                                                      
REMARK 465     ALA F    11                                                      
REMARK 465     ALA F    12                                                      
REMARK 465     LYS F    13                                                      
REMARK 465     ALA F    14                                                      
REMARK 465     SER F    15                                                      
REMARK 465     GLN F    16                                                      
REMARK 465     PRO F   118                                                      
REMARK 465     LYS F   119                                                      
REMARK 465     LYS F   120                                                      
REMARK 465     SER F   121                                                      
REMARK 465     ALA F   122                                                      
REMARK 465     LYS F   123                                                      
REMARK 465     ALA F   124                                                      
REMARK 465     THR F   125                                                      
REMARK 465     LYS F   126                                                      
REMARK 465     ALA F   127                                                      
REMARK 465     SER F   128                                                      
REMARK 465     GLN F   129                                                      
REMARK 465     GLU F   130                                                      
REMARK 465     LEU F   131                                                      
REMARK 465     MET G     0                                                      
REMARK 465     SER G     1                                                      
REMARK 465     ALA G     2                                                      
REMARK 465     LYS G     3                                                      
REMARK 465     ALA G     4                                                      
REMARK 465     GLU G     5                                                      
REMARK 465     LYS G     6                                                      
REMARK 465     LYS G     7                                                      
REMARK 465     PRO G     8                                                      
REMARK 465     ALA G     9                                                      
REMARK 465     SER G    10                                                      
REMARK 465     LYS G    11                                                      
REMARK 465     ALA G    12                                                      
REMARK 465     PRO G    13                                                      
REMARK 465     ALA G    14                                                      
REMARK 465     GLU G    15                                                      
REMARK 465     LYS G    16                                                      
REMARK 465     LYS G    17                                                      
REMARK 465     PRO G    18                                                      
REMARK 465     ALA G    19                                                      
REMARK 465     ALA G    20                                                      
REMARK 465     LYS G    21                                                      
REMARK 465     LYS G    22                                                      
REMARK 465     THR G    23                                                      
REMARK 465     SER G    24                                                      
REMARK 465     THR G    25                                                      
REMARK 465     SER G    26                                                      
REMARK 465     THR G    27                                                      
REMARK 465     ASP G    28                                                      
REMARK 465     GLY G    29                                                      
REMARK 465     LYS G    30                                                      
REMARK 465     LYS G    31                                                      
REMARK 465     ARG G    32                                                      
REMARK 465     GLN G   129                                                      
REMARK 465     ALA G   130                                                      
REMARK 465     MET H     0                                                      
REMARK 465     SER H     1                                                      
REMARK 465     ALA H     2                                                      
REMARK 465     LYS H     3                                                      
REMARK 465     ALA H     4                                                      
REMARK 465     GLU H     5                                                      
REMARK 465     LYS H     6                                                      
REMARK 465     LYS H     7                                                      
REMARK 465     PRO H     8                                                      
REMARK 465     ALA H     9                                                      
REMARK 465     SER H    10                                                      
REMARK 465     LYS H    11                                                      
REMARK 465     ALA H    12                                                      
REMARK 465     PRO H    13                                                      
REMARK 465     ALA H    14                                                      
REMARK 465     GLU H    15                                                      
REMARK 465     LYS H    16                                                      
REMARK 465     LYS H    17                                                      
REMARK 465     PRO H    18                                                      
REMARK 465     ALA H    19                                                      
REMARK 465     ALA H    20                                                      
REMARK 465     LYS H    21                                                      
REMARK 465     LYS H    22                                                      
REMARK 465     THR H    23                                                      
REMARK 465     SER H    24                                                      
REMARK 465     THR H    25                                                      
REMARK 465     SER H    26                                                      
REMARK 465     THR H    27                                                      
REMARK 465     ASP H    28                                                      
REMARK 465     GLY H    29                                                      
REMARK 465     LYS H    30                                                      
REMARK 465     LYS H    31                                                      
REMARK 465     ARG H    32                                                      
REMARK 465     SER H    33                                                      
REMARK 465     LYS H    34                                                      
REMARK 465     SER H   126                                                      
REMARK 465     SER H   127                                                      
REMARK 465     THR H   128                                                      
REMARK 465     GLN H   129                                                      
REMARK 465     ALA H   130                                                      
REMARK 465     MET M     1                                                      
REMARK 465     THR M     2                                                      
REMARK 465     THR M     3                                                      
REMARK 465     SER M     4                                                      
REMARK 465     ARG M     5                                                      
REMARK 465     LYS M     6                                                      
REMARK 465     SER M     7                                                      
REMARK 465     HIS M     8                                                      
REMARK 465     ALA M     9                                                      
REMARK 465     LYS M    10                                                      
REMARK 465     ASP M    11                                                      
REMARK 465     LYS M    12                                                      
REMARK 465     LYS M    13                                                      
REMARK 465     ALA M    14                                                      
REMARK 465     GLY M    15                                                      
REMARK 465     GLY M    16                                                      
REMARK 465     GLU M    17                                                      
REMARK 465     GLN M    18                                                      
REMARK 465     ASP M    19                                                      
REMARK 465     LEU M    20                                                      
REMARK 465     ALA M    21                                                      
REMARK 465     ASP M    22                                                      
REMARK 465     LEU M    23                                                      
REMARK 465     LYS M    24                                                      
REMARK 465     PHE M    25                                                      
REMARK 465     ARG M    26                                                      
REMARK 465     TYR M    27                                                      
REMARK 465     ASP M    28                                                      
REMARK 465     LEU M    29                                                      
REMARK 465     LEU M    30                                                      
REMARK 465     THR M    31                                                      
REMARK 465     ASN M    32                                                      
REMARK 465     GLU M    33                                                      
REMARK 465     LEU M    34                                                      
REMARK 465     PHE M    35                                                      
REMARK 465     HIS M    36                                                      
REMARK 465     LEU M    37                                                      
REMARK 465     ARG M    38                                                      
REMARK 465     GLU M    39                                                      
REMARK 465     PHE M    40                                                      
REMARK 465     VAL M    41                                                      
REMARK 465     SER M    42                                                      
REMARK 465     LEU M    43                                                      
REMARK 465     VAL M    44                                                      
REMARK 465     ASP M    45                                                      
REMARK 465     TYR M    46                                                      
REMARK 465     ASP M    47                                                      
REMARK 465     PRO M    48                                                      
REMARK 465     THR M    49                                                      
REMARK 465     HIS M    50                                                      
REMARK 465     PHE M    51                                                      
REMARK 465     ASN M    52                                                      
REMARK 465     ASP M    53                                                      
REMARK 465     SER M    54                                                      
REMARK 465     GLU M    55                                                      
REMARK 465     SER M    56                                                      
REMARK 465     PHE M    57                                                      
REMARK 465     GLN M    58                                                      
REMARK 465     LYS M    59                                                      
REMARK 465     PHE M    60                                                      
REMARK 465     LEU M    61                                                      
REMARK 465     ARG M    62                                                      
REMARK 465     GLU M    63                                                      
REMARK 465     THR M    64                                                      
REMARK 465     HIS M    65                                                      
REMARK 465     LEU M    66                                                      
REMARK 465     SER M    67                                                      
REMARK 465     LEU M    68                                                      
REMARK 465     GLU M    69                                                      
REMARK 465     GLU M    70                                                      
REMARK 465     ARG M    71                                                      
REMARK 465     GLY M    72                                                      
REMARK 465     GLU M    73                                                      
REMARK 465     LYS M    74                                                      
REMARK 465     PHE M    75                                                      
REMARK 465     THR M    76                                                      
REMARK 465     ASP M    77                                                      
REMARK 465     ASP M    78                                                      
REMARK 465     VAL M    79                                                      
REMARK 465     ALA M    80                                                      
REMARK 465     LYS M    81                                                      
REMARK 465     LYS M    82                                                      
REMARK 465     GLY M    83                                                      
REMARK 465     THR M    84                                                      
REMARK 465     ASN M    85                                                      
REMARK 465     GLY M    86                                                      
REMARK 465     ASP M    87                                                      
REMARK 465     LEU M    88                                                      
REMARK 465     THR M    89                                                      
REMARK 465     ARG M    90                                                      
REMARK 465     ARG M    91                                                      
REMARK 465     ARG M    92                                                      
REMARK 465     ARG M    93                                                      
REMARK 465     ASN M    94                                                      
REMARK 465     LEU M    95                                                      
REMARK 465     ARG M    96                                                      
REMARK 465     THR M    97                                                      
REMARK 465     SER M    98                                                      
REMARK 465     THR M    99                                                      
REMARK 465     VAL M   100                                                      
REMARK 465     VAL M   101                                                      
REMARK 465     SER M   102                                                      
REMARK 465     SER M   103                                                      
REMARK 465     GLU M   104                                                      
REMARK 465     THR M   105                                                      
REMARK 465     THR M   106                                                      
REMARK 465     ASN M   107                                                      
REMARK 465     GLU M   108                                                      
REMARK 465     LYS M   109                                                      
REMARK 465     LYS M   110                                                      
REMARK 465     GLY M   111                                                      
REMARK 465     ASP M   112                                                      
REMARK 465     ILE M   113                                                      
REMARK 465     GLU M   114                                                      
REMARK 465     LEU M   115                                                      
REMARK 465     LYS M   116                                                      
REMARK 465     LEU M   117                                                      
REMARK 465     GLU M   118                                                      
REMARK 465     SER M   119                                                      
REMARK 465     ILE M   120                                                      
REMARK 465     ALA M   121                                                      
REMARK 465     PRO M   122                                                      
REMARK 465     LEU M   123                                                      
REMARK 465     VAL M   124                                                      
REMARK 465     ARG M   125                                                      
REMARK 465     ASN M   126                                                      
REMARK 465     LYS M   127                                                      
REMARK 465     CYS M   128                                                      
REMARK 465     GLU M   129                                                      
REMARK 465     GLU M   130                                                      
REMARK 465     LEU M   131                                                      
REMARK 465     LYS M   132                                                      
REMARK 465     TYR M   133                                                      
REMARK 465     LYS M   134                                                      
REMARK 465     LEU M   135                                                      
REMARK 465     SER M   136                                                      
REMARK 465     ASP M   137                                                      
REMARK 465     HIS M   138                                                      
REMARK 465     SER M   139                                                      
REMARK 465     ASN M   140                                                      
REMARK 465     ARG M   141                                                      
REMARK 465     LYS M   142                                                      
REMARK 465     SER M   143                                                      
REMARK 465     ILE M   144                                                      
REMARK 465     VAL M   145                                                      
REMARK 465     PRO M   146                                                      
REMARK 465     GLN M   147                                                      
REMARK 465     LYS M   148                                                      
REMARK 465     ARG M   149                                                      
REMARK 465     PRO M   150                                                      
REMARK 465     ILE M   151                                                      
REMARK 465     GLN M   152                                                      
REMARK 465     HIS M   153                                                      
REMARK 465     LEU M   154                                                      
REMARK 465     LYS M   155                                                      
REMARK 465     LYS M   156                                                      
REMARK 465     ARG M   157                                                      
REMARK 465     GLU M   158                                                      
REMARK 465     ALA M   159                                                      
REMARK 465     ALA M   160                                                      
REMARK 465     LYS M   161                                                      
REMARK 465     SER M   162                                                      
REMARK 465     LEU M   163                                                      
REMARK 465     LYS M   164                                                      
REMARK 465     PHE M   165                                                      
REMARK 465     LYS M   166                                                      
REMARK 465     SER M   167                                                      
REMARK 465     GLU M   168                                                      
REMARK 465     ARG M   169                                                      
REMARK 465     LYS M   170                                                      
REMARK 465     GLU M   171                                                      
REMARK 465     ASN M   172                                                      
REMARK 465     PRO M   173                                                      
REMARK 465     LEU M   174                                                      
REMARK 465     PRO M   175                                                      
REMARK 465     LEU M   176                                                      
REMARK 465     HIS M   177                                                      
REMARK 465     GLU M   178                                                      
REMARK 465     HIS M   179                                                      
REMARK 465     ILE M   180                                                      
REMARK 465     ALA M   181                                                      
REMARK 465     GLU M   182                                                      
REMARK 465     GLU M   183                                                      
REMARK 465     ARG M   184                                                      
REMARK 465     TYR M   185                                                      
REMARK 465     ASP M   186                                                      
REMARK 465     HIS M   187                                                      
REMARK 465     ILE M   188                                                      
REMARK 465     ALA M   189                                                      
REMARK 465     LYS M   190                                                      
REMARK 465     VAL M   191                                                      
REMARK 465     GLU M   192                                                      
REMARK 465     GLU M   193                                                      
REMARK 465     PRO M   194                                                      
REMARK 465     SER M   195                                                      
REMARK 465     GLU M   196                                                      
REMARK 465     ALA M   197                                                      
REMARK 465     PHE M   198                                                      
REMARK 465     THR M   199                                                      
REMARK 465     ILE M   200                                                      
REMARK 465     LYS M   201                                                      
REMARK 465     CYS M   202                                                      
REMARK 465     PRO M   203                                                      
REMARK 465     SER M   204                                                      
REMARK 465     ASP M   205                                                      
REMARK 465     ASP M   206                                                      
REMARK 465     SER M   207                                                      
REMARK 465     SER M   208                                                      
REMARK 465     PHE M   209                                                      
REMARK 465     GLU M   210                                                      
REMARK 465     ASN M   211                                                      
REMARK 465     THR M   212                                                      
REMARK 465     SER M   213                                                      
REMARK 465     GLU M   214                                                      
REMARK 465     HIS M   215                                                      
REMARK 465     TYR M   216                                                      
REMARK 465     SER M   217                                                      
REMARK 465     ASP M   218                                                      
REMARK 465     ASN M   219                                                      
REMARK 465     PHE M   220                                                      
REMARK 465     TYR M   221                                                      
REMARK 465     PHE M   222                                                      
REMARK 465     THR M   223                                                      
REMARK 465     THR M   224                                                      
REMARK 465     SER M   225                                                      
REMARK 465     SER M   226                                                      
REMARK 465     GLU M   227                                                      
REMARK 465     GLU M   228                                                      
REMARK 465     GLU M   229                                                      
REMARK 465     ASP M   230                                                      
REMARK 465     ILE M   231                                                      
REMARK 465     LYS M   232                                                      
REMARK 465     LYS M   233                                                      
REMARK 465     LYS M   234                                                      
REMARK 465     ARG M   235                                                      
REMARK 465     GLY M   236                                                      
REMARK 465     ARG M   237                                                      
REMARK 465     LYS M   238                                                      
REMARK 465     LYS M   239                                                      
REMARK 465     LYS M   240                                                      
REMARK 465     LYS M   241                                                      
REMARK 465     PRO M   242                                                      
REMARK 465     ARG M   243                                                      
REMARK 465     ILE M   244                                                      
REMARK 465     LYS M   245                                                      
REMARK 465     LEU M   246                                                      
REMARK 465     VAL M   247                                                      
REMARK 465     VAL M   248                                                      
REMARK 465     HIS M   249                                                      
REMARK 465     PRO M   250                                                      
REMARK 465     PRO M   251                                                      
REMARK 465     LYS M   252                                                      
REMARK 465     GLN M   253                                                      
REMARK 465     THR M   254                                                      
REMARK 465     ILE M   255                                                      
REMARK 465     THR M   256                                                      
REMARK 465     ASN M   257                                                      
REMARK 465     PRO M   258                                                      
REMARK 465     LEU M   259                                                      
REMARK 465     HIS M   260                                                      
REMARK 465     VAL M   261                                                      
REMARK 465     VAL M   262                                                      
REMARK 465     LYS M   263                                                      
REMARK 465     PRO M   264                                                      
REMARK 465     GLY M   265                                                      
REMARK 465     TYR M   266                                                      
REMARK 465     GLU M   267                                                      
REMARK 465     SER M   268                                                      
REMARK 465     LEU M   269                                                      
REMARK 465     HIS M   270                                                      
REMARK 465     GLU M   271                                                      
REMARK 465     TYR M   272                                                      
REMARK 465     ILE M   273                                                      
REMARK 465     ALA M   274                                                      
REMARK 465     SER M   275                                                      
REMARK 465     PHE M   276                                                      
REMARK 465     LYS M   277                                                      
REMARK 465     SER M   278                                                      
REMARK 465     LEU M   279                                                      
REMARK 465     GLU M   280                                                      
REMARK 465     ASP M   281                                                      
REMARK 465     ASP M   282                                                      
REMARK 465     LEU M   283                                                      
REMARK 465     THR M   284                                                      
REMARK 465     LEU M   285                                                      
REMARK 465     GLU M   286                                                      
REMARK 465     GLU M   287                                                      
REMARK 465     TYR M   288                                                      
REMARK 465     ASN M   289                                                      
REMARK 465     LYS M   290                                                      
REMARK 465     TYR M   291                                                      
REMARK 465     ILE M   292                                                      
REMARK 465     ASP M   293                                                      
REMARK 465     GLU M   294                                                      
REMARK 465     GLN M   295                                                      
REMARK 465     ARG M   296                                                      
REMARK 465     ARG M   297                                                      
REMARK 465     LEU M   298                                                      
REMARK 465     LEU M   299                                                      
REMARK 465     SER M   300                                                      
REMARK 465     ARG M   301                                                      
REMARK 465     LEU M   302                                                      
REMARK 465     LYS M   303                                                      
REMARK 465     LYS M   304                                                      
REMARK 465     GLY M   305                                                      
REMARK 465     ILE M   306                                                      
REMARK 465     GLU M   307                                                      
REMARK 465     ASN M   308                                                      
REMARK 465     GLY M   309                                                      
REMARK 465     ALA M   310                                                      
REMARK 465     LEU M   311                                                      
REMARK 465     LYS M   312                                                      
REMARK 465     TYR M   313                                                      
REMARK 465     ASP M   314                                                      
REMARK 465     LYS M   315                                                      
REMARK 465     GLU M   316                                                      
REMARK 465     THR M   317                                                      
REMARK 465     ASP M   318                                                      
REMARK 465     SER M   319                                                      
REMARK 465     LEU M   320                                                      
REMARK 465     GLN M   321                                                      
REMARK 465     PRO M   322                                                      
REMARK 465     ILE M   323                                                      
REMARK 465     THR M   324                                                      
REMARK 465     SER M   325                                                      
REMARK 465     LYS M   326                                                      
REMARK 465     GLU M   327                                                      
REMARK 465     ILE M   328                                                      
REMARK 465     LYS M   329                                                      
REMARK 465     THR M   330                                                      
REMARK 465     ILE M   331                                                      
REMARK 465     ILE M   332                                                      
REMARK 465     THR M   333                                                      
REMARK 465     TYR M   334                                                      
REMARK 465     LYS M   335                                                      
REMARK 465     PRO M   336                                                      
REMARK 465     ASP M   337                                                      
REMARK 465     PRO M   338                                                      
REMARK 465     ILE M   339                                                      
REMARK 465     SER M   340                                                      
REMARK 465     TYR M   341                                                      
REMARK 465     PHE M   342                                                      
REMARK 465     TYR M   343                                                      
REMARK 465     LYS M   344                                                      
REMARK 465     GLN M   345                                                      
REMARK 465     GLN M   346                                                      
REMARK 465     ASP M   347                                                      
REMARK 465     LEU M   348                                                      
REMARK 465     GLN M   349                                                      
REMARK 465     ILE M   350                                                      
REMARK 465     HIS M   351                                                      
REMARK 465     THR M   352                                                      
REMARK 465     ASP M   353                                                      
REMARK 465     HIS M   354                                                      
REMARK 465     LEU M   355                                                      
REMARK 465     ILE M   356                                                      
REMARK 465     ASN M   357                                                      
REMARK 465     GLN M   358                                                      
REMARK 465     GLY M   359                                                      
REMARK 465     ILE M   360                                                      
REMARK 465     HIS M   361                                                      
REMARK 465     MET M   362                                                      
REMARK 465     SER M   363                                                      
REMARK 465     LYS M   364                                                      
REMARK 465     LEU M   365                                                      
REMARK 465     PHE M   366                                                      
REMARK 465     ARG M   367                                                      
REMARK 465     SER M   368                                                      
REMARK 465     SER M   369                                                      
REMARK 465     THR M   370                                                      
REMARK 465     LYS M   371                                                      
REMARK 465     ALA M   372                                                      
REMARK 465     ARG M   373                                                      
REMARK 465     ILE M   374                                                      
REMARK 465     ALA M   375                                                      
REMARK 465     ARG M   376                                                      
REMARK 465     ALA M   377                                                      
REMARK 465     LYS M   378                                                      
REMARK 465     LYS M   379                                                      
REMARK 465     VAL M   380                                                      
REMARK 465     SER M   381                                                      
REMARK 465     GLN M   382                                                      
REMARK 465     MET M   383                                                      
REMARK 465     ILE M   384                                                      
REMARK 465     GLU M   385                                                      
REMARK 465     GLN M   386                                                      
REMARK 465     HIS M   387                                                      
REMARK 465     PHE M   388                                                      
REMARK 465     LYS M   389                                                      
REMARK 465     HIS M   390                                                      
REMARK 465     VAL M   391                                                      
REMARK 465     ALA M   392                                                      
REMARK 465     GLY M   393                                                      
REMARK 465     ALA M   394                                                      
REMARK 465     GLU M   395                                                      
REMARK 465     GLU M   396                                                      
REMARK 465     ARG M   397                                                      
REMARK 465     LYS M   398                                                      
REMARK 465     ALA M   399                                                      
REMARK 465     LYS M   400                                                      
REMARK 465     GLU M   401                                                      
REMARK 465     GLU M   402                                                      
REMARK 465     GLU M   403                                                      
REMARK 465     ARG M   404                                                      
REMARK 465     HIS M   405                                                      
REMARK 465     LYS M   406                                                      
REMARK 465     LYS M   407                                                      
REMARK 465     SER M   408                                                      
REMARK 465     LEU M   409                                                      
REMARK 465     ALA M   410                                                      
REMARK 465     ARG M   411                                                      
REMARK 465     PHE M   412                                                      
REMARK 465     ALA M   413                                                      
REMARK 465     VAL M   414                                                      
REMARK 465     GLN M   415                                                      
REMARK 465     ALA M   416                                                      
REMARK 465     VAL M   417                                                      
REMARK 465     LYS M   418                                                      
REMARK 465     LYS M   419                                                      
REMARK 465     ARG M   420                                                      
REMARK 465     TRP M   421                                                      
REMARK 465     ASN M   422                                                      
REMARK 465     MET M   423                                                      
REMARK 465     ALA M   424                                                      
REMARK 465     GLU M   425                                                      
REMARK 465     LYS M   426                                                      
REMARK 465     ALA M   427                                                      
REMARK 465     TYR M   428                                                      
REMARK 465     ARG M   429                                                      
REMARK 465     ILE M   430                                                      
REMARK 465     LEU M   431                                                      
REMARK 465     ARG M   432                                                      
REMARK 465     LYS M   433                                                      
REMARK 465     ASP M   434                                                      
REMARK 465     GLU M   435                                                      
REMARK 465     GLU M   436                                                      
REMARK 465     GLU M   437                                                      
REMARK 465     GLN M   438                                                      
REMARK 465     LEU M   439                                                      
REMARK 465     LYS M   440                                                      
REMARK 465     ARG M   441                                                      
REMARK 465     ILE M   442                                                      
REMARK 465     GLU M   443                                                      
REMARK 465     GLY M   444                                                      
REMARK 465     LYS M   445                                                      
REMARK 465     GLN M   446                                                      
REMARK 465     HIS M   447                                                      
REMARK 465     LEU M   448                                                      
REMARK 465     SER M   449                                                      
REMARK 465     LYS M   450                                                      
REMARK 465     MET M   451                                                      
REMARK 465     LEU M   452                                                      
REMARK 465     GLU M   453                                                      
REMARK 465     LYS M   454                                                      
REMARK 465     SER M   455                                                      
REMARK 465     THR M   456                                                      
REMARK 465     GLN M   457                                                      
REMARK 465     LEU M   458                                                      
REMARK 465     LEU M   459                                                      
REMARK 465     GLU M   460                                                      
REMARK 465     ALA M   461                                                      
REMARK 465     GLN M   462                                                      
REMARK 465     LEU M   463                                                      
REMARK 465     ASN M   464                                                      
REMARK 465     GLN M   465                                                      
REMARK 465     VAL M   466                                                      
REMARK 465     ASN M   467                                                      
REMARK 465     ASP M   468                                                      
REMARK 465     ASP M   469                                                      
REMARK 465     GLY M   470                                                      
REMARK 465     ARG M   471                                                      
REMARK 465     SER M   472                                                      
REMARK 465     SER M   473                                                      
REMARK 465     THR M   474                                                      
REMARK 465     PRO M   475                                                      
REMARK 465     SER M   476                                                      
REMARK 465     SER M   477                                                      
REMARK 465     ASP M   478                                                      
REMARK 465     SER M   479                                                      
REMARK 465     ASN M   480                                                      
REMARK 465     ASP M   481                                                      
REMARK 465     VAL M   482                                                      
REMARK 465     LEU M   483                                                      
REMARK 465     SER M   484                                                      
REMARK 465     GLU M   485                                                      
REMARK 465     SER M   486                                                      
REMARK 465     ASP M   487                                                      
REMARK 465     ASP M   488                                                      
REMARK 465     ASP M   489                                                      
REMARK 465     MET M   490                                                      
REMARK 465     ASP M   491                                                      
REMARK 465     ASP M   492                                                      
REMARK 465     GLU M   493                                                      
REMARK 465     LEU M   494                                                      
REMARK 465     SER M   495                                                      
REMARK 465     THR M   496                                                      
REMARK 465     SER M   497                                                      
REMARK 465     SER M   498                                                      
REMARK 465     ASP M   499                                                      
REMARK 465     GLU M   500                                                      
REMARK 465     ASP M   501                                                      
REMARK 465     GLU M   502                                                      
REMARK 465     GLU M   503                                                      
REMARK 465     VAL M   504                                                      
REMARK 465     ASP M   505                                                      
REMARK 465     ALA M   506                                                      
REMARK 465     ASP M   507                                                      
REMARK 465     VAL M   508                                                      
REMARK 465     GLY M   509                                                      
REMARK 465     LEU M   510                                                      
REMARK 465     GLU M   511                                                      
REMARK 465     ASN M   512                                                      
REMARK 465     SER M   513                                                      
REMARK 465     PRO M   514                                                      
REMARK 465     ALA M   515                                                      
REMARK 465     SER M   516                                                      
REMARK 465     THR M   517                                                      
REMARK 465     GLU M   518                                                      
REMARK 465     ALA M   519                                                      
REMARK 465     THR M   520                                                      
REMARK 465     PRO M   521                                                      
REMARK 465     THR M   522                                                      
REMARK 465     ASP M   523                                                      
REMARK 465     GLU M   524                                                      
REMARK 465     SER M   525                                                      
REMARK 465     LEU M   526                                                      
REMARK 465     ASN M   527                                                      
REMARK 465     LEU M   528                                                      
REMARK 465     ILE M   529                                                      
REMARK 465     GLN M   530                                                      
REMARK 465     LEU M   531                                                      
REMARK 465     LYS M   532                                                      
REMARK 465     GLU M   533                                                      
REMARK 465     LYS M   534                                                      
REMARK 465     TYR M   535                                                      
REMARK 465     GLY M   536                                                      
REMARK 465     HIS M   537                                                      
REMARK 465     PHE M   538                                                      
REMARK 465     ASN M   539                                                      
REMARK 465     GLY M   540                                                      
REMARK 465     SER M   541                                                      
REMARK 465     SER M   542                                                      
REMARK 465     THR M   543                                                      
REMARK 465     VAL M   544                                                      
REMARK 465     TYR M   545                                                      
REMARK 465     ASP M   546                                                      
REMARK 465     SER M   547                                                      
REMARK 465     ARG M   548                                                      
REMARK 465     ASN M   549                                                      
REMARK 465     LYS M   550                                                      
REMARK 465     ASP M   551                                                      
REMARK 465     GLU M   552                                                      
REMARK 465     LYS M   553                                                      
REMARK 465     PHE M   554                                                      
REMARK 465     PRO M   555                                                      
REMARK 465     THR M   556                                                      
REMARK 465     LEU M   557                                                      
REMARK 465     ASP M   558                                                      
REMARK 465     LYS M   559                                                      
REMARK 465     HIS M   560                                                      
REMARK 465     GLU M   561                                                      
REMARK 465     SER M   562                                                      
REMARK 465     SER M   563                                                      
REMARK 465     SER M   564                                                      
REMARK 465     SER M   565                                                      
REMARK 465     GLU M   566                                                      
REMARK 465     SER M   567                                                      
REMARK 465     SER M   568                                                      
REMARK 465     VAL M   569                                                      
REMARK 465     MET M   570                                                      
REMARK 465     THR M   571                                                      
REMARK 465     GLY M   572                                                      
REMARK 465     GLU M   573                                                      
REMARK 465     GLU M   574                                                      
REMARK 465     SER M   575                                                      
REMARK 465     SER M   576                                                      
REMARK 465     ILE M   577                                                      
REMARK 465     TYR M   578                                                      
REMARK 465     SER M   579                                                      
REMARK 465     SER M   580                                                      
REMARK 465     SER M   581                                                      
REMARK 465     GLU M   582                                                      
REMARK 465     ASN M   583                                                      
REMARK 465     GLU M   584                                                      
REMARK 465     SER M   585                                                      
REMARK 465     GLN M   586                                                      
REMARK 465     ASN M   587                                                      
REMARK 465     GLU M   588                                                      
REMARK 465     ASN M   589                                                      
REMARK 465     ASP M   590                                                      
REMARK 465     ARG M   591                                                      
REMARK 465     GLU M   592                                                      
REMARK 465     SER M   593                                                      
REMARK 465     ASP M   594                                                      
REMARK 465     ASP M   595                                                      
REMARK 465     LYS M   596                                                      
REMARK 465     THR M   597                                                      
REMARK 465     PRO M   598                                                      
REMARK 465     SER M   599                                                      
REMARK 465     VAL M   600                                                      
REMARK 465     GLY M   601                                                      
REMARK 465     LEU M   602                                                      
REMARK 465     SER M   603                                                      
REMARK 465     ALA M   604                                                      
REMARK 465     LEU M   605                                                      
REMARK 465     PHE M   606                                                      
REMARK 465     GLY M   607                                                      
REMARK 465     LYS M   608                                                      
REMARK 465     GLY M   609                                                      
REMARK 465     GLU M   610                                                      
REMARK 465     GLU M   611                                                      
REMARK 465     SER M   612                                                      
REMARK 465     ASP M   613                                                      
REMARK 465     GLY M   614                                                      
REMARK 465     ASP M   615                                                      
REMARK 465     LEU M   616                                                      
REMARK 465     ASP M   617                                                      
REMARK 465     LEU M   618                                                      
REMARK 465     ASP M   619                                                      
REMARK 465     ASP M   620                                                      
REMARK 465     SER M   621                                                      
REMARK 465     GLU M   622                                                      
REMARK 465     ASP M   623                                                      
REMARK 465     PHE M   624                                                      
REMARK 465     THR M   625                                                      
REMARK 465     VAL M   626                                                      
REMARK 465     ASN M   627                                                      
REMARK 465     SER M   628                                                      
REMARK 465     SER M   629                                                      
REMARK 465     SER M   630                                                      
REMARK 465     VAL M   631                                                      
REMARK 465     GLU M   632                                                      
REMARK 465     GLY M   633                                                      
REMARK 465     GLU M   634                                                      
REMARK 465     GLU M   635                                                      
REMARK 465     LEU M   636                                                      
REMARK 465     GLU M   637                                                      
REMARK 465     LYS M   638                                                      
REMARK 465     ASP M   639                                                      
REMARK 465     GLN M   640                                                      
REMARK 465     VAL M   641                                                      
REMARK 465     ASP M   642                                                      
REMARK 465     ASN M   643                                                      
REMARK 465     SER M   644                                                      
REMARK 465     ALA M   645                                                      
REMARK 465     ALA M   646                                                      
REMARK 465     THR M   647                                                      
REMARK 465     PHE M   648                                                      
REMARK 465     GLU M   649                                                      
REMARK 465     ARG M   650                                                      
REMARK 465     ALA M   651                                                      
REMARK 465     GLY M   652                                                      
REMARK 465     ASP M   653                                                      
REMARK 465     PHE M   654                                                      
REMARK 465     VAL M   655                                                      
REMARK 465     HIS M   656                                                      
REMARK 465     THR M   657                                                      
REMARK 465     GLN M   658                                                      
REMARK 465     ASN M   659                                                      
REMARK 465     GLU M   660                                                      
REMARK 465     ASN M   661                                                      
REMARK 465     ARG M   662                                                      
REMARK 465     ASP M   663                                                      
REMARK 465     ASP M   664                                                      
REMARK 465     ILE M   665                                                      
REMARK 465     LYS M   666                                                      
REMARK 465     ASP M   667                                                      
REMARK 465     VAL M   668                                                      
REMARK 465     GLU M   669                                                      
REMARK 465     GLU M   670                                                      
REMARK 465     ASP M   671                                                      
REMARK 465     ALA M   672                                                      
REMARK 465     GLU M   673                                                      
REMARK 465     THR M   674                                                      
REMARK 465     LYS M   675                                                      
REMARK 465     VAL M   676                                                      
REMARK 465     GLN M   677                                                      
REMARK 465     GLU M   678                                                      
REMARK 465     GLU M   679                                                      
REMARK 465     GLN M   680                                                      
REMARK 465     LEU M   681                                                      
REMARK 465     ASP M   886                                                      
REMARK 465     LEU M   887                                                      
REMARK 465     ASP M   888                                                      
REMARK 465     ALA M   889                                                      
REMARK 465     PHE M   890                                                      
REMARK 465     GLN M   891                                                      
REMARK 465     GLN M   892                                                      
REMARK 465     TRP M   893                                                      
REMARK 465     PHE M   894                                                      
REMARK 465     GLY M   895                                                      
REMARK 465     ARG M   896                                                      
REMARK 465     PRO M   897                                                      
REMARK 465     VAL M   898                                                      
REMARK 465     ASP M   899                                                      
REMARK 465     LYS M   900                                                      
REMARK 465     ILE M   901                                                      
REMARK 465     ILE M   902                                                      
REMARK 465     GLU M   903                                                      
REMARK 465     THR M   904                                                      
REMARK 465     GLY M   905                                                      
REMARK 465     GLN M   906                                                      
REMARK 465     ASN M   907                                                      
REMARK 465     PHE M   908                                                      
REMARK 465     GLY M   909                                                      
REMARK 465     GLN M   910                                                      
REMARK 465     ASP M   911                                                      
REMARK 465     LYS M   912                                                      
REMARK 465     GLY M  1397                                                      
REMARK 465     ASP M  1398                                                      
REMARK 465     PHE M  1399                                                      
REMARK 465     THR M  1400                                                      
REMARK 465     THR M  1401                                                      
REMARK 465     ASP M  1402                                                      
REMARK 465     TYR M  1403                                                      
REMARK 465     PHE M  1404                                                      
REMARK 465     SER M  1405                                                      
REMARK 465     LYS M  1406                                                      
REMARK 465     LEU M  1407                                                      
REMARK 465     SER M  1408                                                      
REMARK 465     VAL M  1409                                                      
REMARK 465     ARG M  1410                                                      
REMARK 465     ASP M  1411                                                      
REMARK 465     LEU M  1412                                                      
REMARK 465     LEU M  1413                                                      
REMARK 465     GLY M  1414                                                      
REMARK 465     SER M  1415                                                      
REMARK 465     GLU M  1416                                                      
REMARK 465     LEU M  1417                                                      
REMARK 465     PRO M  1418                                                      
REMARK 465     GLU M  1419                                                      
REMARK 465     ASN M  1420                                                      
REMARK 465     ALA M  1421                                                      
REMARK 465     SER M  1422                                                      
REMARK 465     GLY M  1423                                                      
REMARK 465     GLY M  1424                                                      
REMARK 465     ASP M  1425                                                      
REMARK 465     LYS M  1426                                                      
REMARK 465     PRO M  1427                                                      
REMARK 465     LEU M  1428                                                      
REMARK 465     ILE M  1429                                                      
REMARK 465     ALA M  1430                                                      
REMARK 465     ASP M  1431                                                      
REMARK 465     ALA M  1432                                                      
REMARK 465     ASP M  1433                                                      
REMARK 465     VAL M  1434                                                      
REMARK 465     ALA M  1435                                                      
REMARK 465     ALA M  1436                                                      
REMARK 465     LYS M  1437                                                      
REMARK 465     ASP M  1438                                                      
REMARK 465     PRO M  1439                                                      
REMARK 465     ARG M  1440                                                      
REMARK 465     GLN M  1441                                                      
REMARK 465     LEU M  1442                                                      
REMARK 465     GLU M  1443                                                      
REMARK 465     ARG M  1444                                                      
REMARK 465     LEU M  1445                                                      
REMARK 465     LEU M  1446                                                      
REMARK 465     ALA M  1447                                                      
REMARK 465     GLN M  1448                                                      
REMARK 465     ALA M  1449                                                      
REMARK 465     GLU M  1450                                                      
REMARK 465     ASP M  1451                                                      
REMARK 465     GLU M  1452                                                      
REMARK 465     ASP M  1453                                                      
REMARK 465     ASP M  1454                                                      
REMARK 465     VAL M  1455                                                      
REMARK 465     LYS M  1456                                                      
REMARK 465     ALA M  1457                                                      
REMARK 465     ALA M  1458                                                      
REMARK 465     ASN M  1459                                                      
REMARK 465     LEU M  1460                                                      
REMARK 465     ALA M  1461                                                      
REMARK 465     MET M  1462                                                      
REMARK 465     ARG M  1463                                                      
REMARK 465     GLU M  1464                                                      
REMARK 465     VAL M  1465                                                      
REMARK 465     GLU M  1466                                                      
REMARK 465     ILE M  1467                                                      
REMARK 465     ASP M  1468                                                      
REMARK 465     ASN M  1469                                                      
REMARK 465     ASP M  1470                                                      
REMARK 465     ASP M  1471                                                      
REMARK 465     PHE M  1472                                                      
REMARK 465     ASP M  1473                                                      
REMARK 465     GLU M  1474                                                      
REMARK 465     SER M  1475                                                      
REMARK 465     THR M  1476                                                      
REMARK 465     GLU M  1477                                                      
REMARK 465     LYS M  1478                                                      
REMARK 465     LYS M  1479                                                      
REMARK 465     ALA M  1480                                                      
REMARK 465     ALA M  1481                                                      
REMARK 465     ASN M  1482                                                      
REMARK 465     GLU M  1483                                                      
REMARK 465     GLU M  1484                                                      
REMARK 465     GLU M  1485                                                      
REMARK 465     GLU M  1486                                                      
REMARK 465     ASN M  1487                                                      
REMARK 465     HIS M  1488                                                      
REMARK 465     ALA M  1489                                                      
REMARK 465     GLU M  1490                                                      
REMARK 465     LEU M  1491                                                      
REMARK 465     ASP M  1492                                                      
REMARK 465     GLU M  1493                                                      
REMARK 465     TYR M  1494                                                      
REMARK 465     GLU M  1495                                                      
REMARK 465     GLY M  1496                                                      
REMARK 465     THR M  1497                                                      
REMARK 465     ALA M  1498                                                      
REMARK 465     HIS M  1499                                                      
REMARK 465     VAL M  1500                                                      
REMARK 465     ASP M  1501                                                      
REMARK 465     GLU M  1502                                                      
REMARK 465     TYR M  1503                                                      
REMARK 465     MET M  1504                                                      
REMARK 465     ILE M  1505                                                      
REMARK 465     ARG M  1506                                                      
REMARK 465     PHE M  1507                                                      
REMARK 465     ILE M  1508                                                      
REMARK 465     ALA M  1509                                                      
REMARK 465     ASN M  1510                                                      
REMARK 465     GLY M  1511                                                      
REMARK 465     TYR M  1512                                                      
REMARK 465     TYR M  1513                                                      
REMARK 465     TYR M  1514                                                      
REMARK 465     MET R     1                                                      
REMARK 465     ASP R   156                                                      
REMARK 465     ILE R   157                                                      
REMARK 465     ASP R   158                                                      
REMARK 465     ILE R   159                                                      
REMARK 465     VAL R   160                                                      
REMARK 465     ARG R   161                                                      
REMARK 465     GLY R   162                                                      
REMARK 465     ASN R   163                                                      
REMARK 465     SER R   164                                                      
REMARK 465     ASP R   165                                                      
REMARK 465     SER R   166                                                      
REMARK 465     THR R   167                                                      
REMARK 465     ASN R   168                                                      
REMARK 465     SER R   169                                                      
REMARK 465     THR R   170                                                      
REMARK 465     SER R   171                                                      
REMARK 465     SER R   172                                                      
REMARK 465     GLU R   173                                                      
REMARK 465     SER R   174                                                      
REMARK 465     LYS R   175                                                      
REMARK 465     ASN R   176                                                      
REMARK 465     ALA R   177                                                      
REMARK 465     GLN R   178                                                      
REMARK 465     ASP R   179                                                      
REMARK 465     SER R   180                                                      
REMARK 465     GLY R   181                                                      
REMARK 465     ASP S    23                                                      
REMARK 465     PRO S    24                                                      
REMARK 465     GLN S    25                                                      
REMARK 465     ALA S    26                                                      
REMARK 465     ARG S    27                                                      
REMARK 465     ARG S    28                                                      
REMARK 465     TYR S    29                                                      
REMARK 465     THR S    30                                                      
REMARK 465     SER S    31                                                      
REMARK 465     LYS S    32                                                      
REMARK 465     LYS S    33                                                      
REMARK 465     ILE S    34                                                      
REMARK 465     ASN S    35                                                      
REMARK 465     LYS S    36                                                      
REMARK 465     GLN S    37                                                      
REMARK 465     GLY S    38                                                      
REMARK 465     THR S    39                                                      
REMARK 465     ILE S    40                                                      
REMARK 465     SER S    41                                                      
REMARK 465     THR S    42                                                      
REMARK 465     SER S    63                                                      
REMARK 465     ARG S    64                                                      
REMARK 465     SER S    65                                                      
REMARK 465     GLU S    66                                                      
REMARK 465     GLY S    67                                                      
REMARK 465     ASP S    68                                                      
REMARK 465     GLY S    69                                                      
REMARK 465     ASN S    70                                                      
REMARK 465     SER S    71                                                      
REMARK 465     ILE S    72                                                      
REMARK 465     SER S    73                                                      
REMARK 465     ARG S    74                                                      
REMARK 465     GLN S    75                                                      
REMARK 465     ASP S    76                                                      
REMARK 465     ASP S    77                                                      
REMARK 465     ARG S    78                                                      
REMARK 465     ASN S    79                                                      
REMARK 465     SER S    80                                                      
REMARK 465     LYS S    81                                                      
REMARK 465     ASN S    82                                                      
REMARK 465     SER S    83                                                      
REMARK 465     HIS S    84                                                      
REMARK 465     SER S    85                                                      
REMARK 465     PHE S    86                                                      
REMARK 465     GLU S    87                                                      
REMARK 465     GLU S    88                                                      
REMARK 465     SER S   139                                                      
REMARK 465     GLN S   140                                                      
REMARK 465     THR S   141                                                      
REMARK 465     SER S   142                                                      
REMARK 465     ASP S   143                                                      
REMARK 465     GLY S   144                                                      
REMARK 465     LEU S   145                                                      
REMARK 465     SER S   146                                                      
REMARK 465     ALA S   147                                                      
REMARK 465     LEU S   148                                                      
REMARK 465     MET S   149                                                      
REMARK 465     GLY S   150                                                      
REMARK 465     GLY S   151                                                      
REMARK 465     SER S   152                                                      
REMARK 465     SER S   153                                                      
REMARK 465     PHE S   154                                                      
REMARK 465     VAL S   155                                                      
REMARK 465     LYS S   156                                                      
REMARK 465     GLU S   157                                                      
REMARK 465     HIS S   158                                                      
REMARK 465     SER S   159                                                      
REMARK 465     LYS S   160                                                      
REMARK 465     TYR S   161                                                      
REMARK 465     GLY S   162                                                      
REMARK 465     HIS S   163                                                      
REMARK 465     GLY S   164                                                      
REMARK 465     MET T     1                                                      
REMARK 465     VAL T     2                                                      
REMARK 465     ALA T     3                                                      
REMARK 465     ILE T     4                                                      
REMARK 465     SER T     5                                                      
REMARK 465     GLU T     6                                                      
REMARK 465     VAL T     7                                                      
REMARK 465     LYS T     8                                                      
REMARK 465     GLU T     9                                                      
REMARK 465     ASN T    10                                                      
REMARK 465     PRO T    11                                                      
REMARK 465     GLY T    12                                                      
REMARK 465     VAL T    13                                                      
REMARK 465     ASN T    14                                                      
REMARK 465     SER T    15                                                      
REMARK 465     SER T    16                                                      
REMARK 465     ASN T    17                                                      
REMARK 465     SER T    18                                                      
REMARK 465     GLY T    19                                                      
REMARK 465     ALA T    20                                                      
REMARK 465     MET U     1                                                      
REMARK 465     SER U     2                                                      
REMARK 465     ILE U     3                                                      
REMARK 465     GLN U     4                                                      
REMARK 465     THR U     5                                                      
REMARK 465     SER U     6                                                      
REMARK 465     ASP U     7                                                      
REMARK 465     PRO U     8                                                      
REMARK 465     ASN U     9                                                      
REMARK 465     GLU U    10                                                      
REMARK 465     THR U    11                                                      
REMARK 465     SER U    12                                                      
REMARK 465     ASP U    13                                                      
REMARK 465     LEU U    14                                                      
REMARK 465     PHE U   206                                                      
REMARK 465     ALA U   207                                                      
REMARK 465     ARG U   208                                                      
REMARK 465     SER U   209                                                      
REMARK 465     ARG U   210                                                      
REMARK 465     ASP U   211                                                      
REMARK 465     TYR U   212                                                      
REMARK 465     ASP U   213                                                      
REMARK 465     ALA U   214                                                      
REMARK 465     MET U   215                                                      
REMARK 465     GLY U   216                                                      
REMARK 465     ALA U   217                                                      
REMARK 465     ASP U   218                                                      
REMARK 465     THR U   219                                                      
REMARK 465     ARG U   220                                                      
REMARK 465     PHE U   221                                                      
REMARK 465     SER U   461                                                      
REMARK 465     ALA U   462                                                      
REMARK 465     ASP U   463                                                      
REMARK 465     PRO U   464                                                      
REMARK 465     ASP U   465                                                      
REMARK 465     ALA U   466                                                      
REMARK 465     MET U   467                                                      
REMARK 465     ASP U   468                                                      
REMARK 465     THR U   469                                                      
REMARK 465     THR U   470                                                      
REMARK 465     GLU U   471                                                      
REMARK 465     MET V     1                                                      
REMARK 465     VAL V     2                                                      
REMARK 465     ALA V     3                                                      
REMARK 465     ILE V     4                                                      
REMARK 465     SER V     5                                                      
REMARK 465     GLU V     6                                                      
REMARK 465     VAL V     7                                                      
REMARK 465     LYS V     8                                                      
REMARK 465     GLU V     9                                                      
REMARK 465     ASN V    10                                                      
REMARK 465     PRO V    11                                                      
REMARK 465     GLY V    12                                                      
REMARK 465     VAL V    13                                                      
REMARK 465     ASN V    14                                                      
REMARK 465     SER V    15                                                      
REMARK 465     SER V    16                                                      
REMARK 465     ASN V    17                                                      
REMARK 465     SER V    18                                                      
REMARK 465     GLY V    19                                                      
REMARK 465     ALA V    20                                                      
REMARK 465     ALA V   152                                                      
REMARK 465     GLU V   153                                                      
REMARK 465     ASN V   154                                                      
REMARK 465     PRO V   155                                                      
REMARK 465     LEU V   156                                                      
REMARK 465     GLY V   157                                                      
REMARK 465     GLY V   158                                                      
REMARK 465     TYR V   159                                                      
REMARK 465     GLY V   160                                                      
REMARK 465     MET W     1                                                      
REMARK 465     SER W     2                                                      
REMARK 465     ILE W     3                                                      
REMARK 465     GLN W     4                                                      
REMARK 465     THR W     5                                                      
REMARK 465     SER W     6                                                      
REMARK 465     ASP W     7                                                      
REMARK 465     PRO W     8                                                      
REMARK 465     ASN W     9                                                      
REMARK 465     GLU W    10                                                      
REMARK 465     THR W    11                                                      
REMARK 465     SER W    12                                                      
REMARK 465     ASP W    13                                                      
REMARK 465     ARG W   208                                                      
REMARK 465     SER W   209                                                      
REMARK 465     ARG W   210                                                      
REMARK 465     ASP W   211                                                      
REMARK 465     TYR W   212                                                      
REMARK 465     ASP W   213                                                      
REMARK 465     ALA W   214                                                      
REMARK 465     MET W   215                                                      
REMARK 465     GLY W   216                                                      
REMARK 465     ALA W   217                                                      
REMARK 465     ASP W   218                                                      
REMARK 465     THR W   219                                                      
REMARK 465     ARG W   220                                                      
REMARK 465     LYS W   460                                                      
REMARK 465     SER W   461                                                      
REMARK 465     ALA W   462                                                      
REMARK 465     ASP W   463                                                      
REMARK 465     PRO W   464                                                      
REMARK 465     ASP W   465                                                      
REMARK 465     ALA W   466                                                      
REMARK 465     MET W   467                                                      
REMARK 465     ASP W   468                                                      
REMARK 465     THR W   469                                                      
REMARK 465     THR W   470                                                      
REMARK 465     GLU W   471                                                      
REMARK 465     MET X     1                                                      
REMARK 465     VAL X     2                                                      
REMARK 465     ALA X     3                                                      
REMARK 465     ILE X     4                                                      
REMARK 465     SER X     5                                                      
REMARK 465     GLU X     6                                                      
REMARK 465     VAL X     7                                                      
REMARK 465     LYS X     8                                                      
REMARK 465     GLU X     9                                                      
REMARK 465     ASN X    10                                                      
REMARK 465     PRO X    11                                                      
REMARK 465     GLY X    12                                                      
REMARK 465     VAL X    13                                                      
REMARK 465     ASN X    14                                                      
REMARK 465     SER X    15                                                      
REMARK 465     SER X    16                                                      
REMARK 465     ASN X    17                                                      
REMARK 465     SER X    18                                                      
REMARK 465     GLY X    19                                                      
REMARK 465     ALA X    20                                                      
REMARK 465     VAL X    21                                                      
REMARK 465     MET Y     1                                                      
REMARK 465     SER Y     2                                                      
REMARK 465     ILE Y     3                                                      
REMARK 465     GLN Y     4                                                      
REMARK 465     THR Y     5                                                      
REMARK 465     SER Y     6                                                      
REMARK 465     ASP Y     7                                                      
REMARK 465     PRO Y     8                                                      
REMARK 465     ASN Y     9                                                      
REMARK 465     GLU Y    10                                                      
REMARK 465     THR Y    11                                                      
REMARK 465     SER Y    12                                                      
REMARK 465     ASP Y    13                                                      
REMARK 465     SER Y   461                                                      
REMARK 465     ALA Y   462                                                      
REMARK 465     ASP Y   463                                                      
REMARK 465     PRO Y   464                                                      
REMARK 465     ASP Y   465                                                      
REMARK 465     ALA Y   466                                                      
REMARK 465     MET Y   467                                                      
REMARK 465     ASP Y   468                                                      
REMARK 465     THR Y   469                                                      
REMARK 465     THR Y   470                                                      
REMARK 465     GLU Y   471                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     LYS A  37    CG   CD   CE   NZ                                   
REMARK 470     LYS B  37    CG   CD   CE   NZ                                   
REMARK 470     ILE C  21    CG1  CG2  CD1                                       
REMARK 470     GLU M 743    CG   CD   OE1  OE2                                  
REMARK 470     ARG M 783    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS M 784    CG   CD   CE   NZ                                   
REMARK 470     LYS M 792    CG   CD   CE   NZ                                   
REMARK 470     CYS M 799    SG                                                  
REMARK 470     ARG M 817    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG M 847    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     TRP M 864    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
REMARK 470     TRP M 864    CZ3  CH2                                            
REMARK 470     LYS M 879    CG   CD   CE   NZ                                   
REMARK 470     LYS M 880    CG   CD   CE   NZ                                   
REMARK 470     VAL M 881    CG1  CG2                                            
REMARK 470     SER M 882    OG                                                  
REMARK 470     PHE M 884    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     GLU M 913    CG   CD   OE1  OE2                                  
REMARK 470     THR M 914    OG1  CG2                                            
REMARK 470     LYS M 915    CG   CD   CE   NZ                                   
REMARK 470     LYS M 916    CG   CD   CE   NZ                                   
REMARK 470     THR M 917    OG1  CG2                                            
REMARK 470     LYS M 920    CG   CD   CE   NZ                                   
REMARK 470     GLN M 923    CG   CD   OE1  NE2                                  
REMARK 470     GLU M 938    CG   CD   OE1  OE2                                  
REMARK 470     LYS M 939    CG   CD   CE   NZ                                   
REMARK 470     ASP M1017    CG   OD1  OD2                                       
REMARK 470     GLN M1034    CG   CD   OE1  NE2                                  
REMARK 470     GLU M1060    CG   CD   OE1  OE2                                  
REMARK 470     GLN M1086    CG   CD   OE1  NE2                                  
REMARK 470     GLU M1087    CG   CD   OE1  OE2                                  
REMARK 470     GLU M1088    CG   CD   OE1  OE2                                  
REMARK 470     PHE M1089    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     GLU M1091    CG   CD   OE1  OE2                                  
REMARK 470     PHE M1094    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     LEU M1095    CG   CD1  CD2                                       
REMARK 470     ASN M1096    CG   OD1  ND2                                       
REMARK 470     PHE M1097    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     GLN M1098    CG   CD   OE1  NE2                                  
REMARK 470     ASP M1099    CG   OD1  OD2                                       
REMARK 470     ASN M1101    CG   OD1  ND2                                       
REMARK 470     GLN M1102    CG   CD   OE1  NE2                                  
REMARK 470     TYR M1103    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     LYS M1109    CG   CD   CE   NZ                                   
REMARK 470     ARG M1129    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LEU M1140    CG   CD1  CD2                                       
REMARK 470     ARG M1149    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ILE M1157    CG1  CG2  CD1                                       
REMARK 470     ASN M1160    CG   OD1  ND2                                       
REMARK 470     GLU M1161    CG   CD   OE1  OE2                                  
REMARK 470     ASP M1191    CG   OD1  OD2                                       
REMARK 470     GLU M1207    CG   CD   OE1  OE2                                  
REMARK 470     PHE M1235    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     LYS M1247    CG   CD   CE   NZ                                   
REMARK 470     LYS M1250    CG   CD   CE   NZ                                   
REMARK 470     GLU M1299    CG   CD   OE1  OE2                                  
REMARK 470     ASP M1311    CG   OD1  OD2                                       
REMARK 470     ASN M1344    CG   OD1  ND2                                       
REMARK 470     GLN M1388    CG   CD   OE1  NE2                                  
REMARK 470     GLN M1395    CG   CD   OE1  NE2                                  
REMARK 470     GLU M1396    CG   CD   OE1  OE2                                  
REMARK 470     GLU T 153    CG   CD   OE1  OE2                                  
REMARK 470     LYS T 161    CG   CD   CE   NZ                                   
REMARK 470     THR T 162    OG1  CG2                                            
REMARK 470     ILE T 163    CG1  CG2  CD1                                       
REMARK 470     LYS U 201    CG   CD   CE   NZ                                   
REMARK 470     ASP V 151    CG   OD1  OD2                                       
REMARK 470     LYS V 161    CG   CD   CE   NZ                                   
REMARK 470     GLN W 223    CG   CD   OE1  NE2                                  
REMARK 470     GLU Y 137    CG   CD   OE1  OE2                                  
REMARK 470     ASP Y 146    CG   OD1  OD2                                       
REMARK 470     ARG Y 147    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     SER Y 148    OG                                                  
REMARK 470     ILE Y 149    CG1  CG2  CD1                                       
REMARK 470     THR Y 150    OG1  CG2                                            
REMARK 470     HIS Y 153    CG   ND1  CD2  CE1  NE2                             
REMARK 470     LYS Y 154    CG   CD   CE   NZ                                   
REMARK 470     LYS Y 181    CG   CD   CE   NZ                                   
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   O3B  ADP R   501    BE    BEF R   502              1.40            
REMARK 500   O1B  ADP M  1601     F2   BEF M  1602              1.84            
REMARK 500   O3B  ADP R   501     F2   BEF R   502              1.92            
REMARK 500   PB   ADP M  1601    BE    BEF M  1602              2.00            
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500     DT I -93   C3' -  C2' -  C1' ANGL. DEV. =  -4.9 DEGREES          
REMARK 500     DT I -59   O4' -  C1' -  N1  ANGL. DEV. =   1.9 DEGREES          
REMARK 500     DT I -28   C3' -  C2' -  C1' ANGL. DEV. =  -5.3 DEGREES          
REMARK 500     DT I -28   O4' -  C1' -  N1  ANGL. DEV. =   2.7 DEGREES          
REMARK 500     DC I -10   O4' -  C1' -  N1  ANGL. DEV. =   2.1 DEGREES          
REMARK 500     DC I  22   O4' -  C1' -  N1  ANGL. DEV. =   2.1 DEGREES          
REMARK 500     DC I  66   O4' -  C1' -  N1  ANGL. DEV. =   1.9 DEGREES          
REMARK 500     DC J -26   O4' -  C1' -  N1  ANGL. DEV. =   2.2 DEGREES          
REMARK 500     DC J  37   O4' -  C1' -  N1  ANGL. DEV. =   2.5 DEGREES          
REMARK 500     DC J  61   O4' -  C1' -  N1  ANGL. DEV. =   2.1 DEGREES          
REMARK 500     DT J  69   O4' -  C1' -  N1  ANGL. DEV. =   2.3 DEGREES          
REMARK 500     DT J  94   O4' -  C1' -  N1  ANGL. DEV. =   2.0 DEGREES          
REMARK 500    PHE M 999   CB  -  CG  -  CD2 ANGL. DEV. =   5.4 DEGREES          
REMARK 500    LEU R  63   CA  -  CB  -  CG  ANGL. DEV. =  14.5 DEGREES          
REMARK 500    LEU R  66   CA  -  CB  -  CG  ANGL. DEV. =  15.2 DEGREES          
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    UNK Z  82     -162.09     56.18                                   
REMARK 500    UNK Z  90     -152.76     55.33                                   
REMARK 500    UNK Z  96     -165.66     56.69                                   
REMARK 500    UNK Z 133      -79.22    -98.30                                   
REMARK 500    UNK Z 134       -5.61     62.16                                   
REMARK 500    UNK Z 135     -140.43     53.25                                   
REMARK 500    UNK Z 145       19.49     57.44                                   
REMARK 500    UNK Z 146     -120.77     52.93                                   
REMARK 500    UNK Z 148     -147.87    -93.22                                   
REMARK 500    UNK Z 159       61.89   -116.46                                   
REMARK 500    UNK Z 161     -122.15     54.48                                   
REMARK 500    UNK Z 180      -81.00    -83.89                                   
REMARK 500    UNK Z 181       75.08     52.56                                   
REMARK 500    UNK Z 184      -92.63     54.83                                   
REMARK 500    UNK Z 186      -89.93   -105.56                                   
REMARK 500    UNK Z 193       83.23     58.16                                   
REMARK 500    UNK Z 194     -152.46   -142.16                                   
REMARK 500    UNK Z 196      140.74     64.21                                   
REMARK 500    UNK Z 198       91.02     55.31                                   
REMARK 500    UNK Z 206      -66.19   -109.68                                   
REMARK 500    UNK Z 207       11.47     55.19                                   
REMARK 500    UNK Z 208       71.72   -156.55                                   
REMARK 500    THR G  51      -62.19    -92.77                                   
REMARK 500    PRO G  53       37.09    -86.07                                   
REMARK 500    THR H  51      -62.12    -92.75                                   
REMARK 500    PRO H  53       37.08    -86.12                                   
REMARK 500    LEU M 692       33.82   -140.67                                   
REMARK 500    TRP M 745      -62.61   -109.84                                   
REMARK 500    ALA M 768       75.28     53.16                                   
REMARK 500    TYR M 928       79.96   -115.37                                   
REMARK 500    LEU M 929      149.51   -170.83                                   
REMARK 500    THR M 973       -5.69     66.55                                   
REMARK 500    ASN M 997       30.33    -89.86                                   
REMARK 500    PHE M 999       -4.60     94.42                                   
REMARK 500    GLU M1000       27.44     47.86                                   
REMARK 500    CYS M1013       72.82     58.71                                   
REMARK 500    LYS M1030       30.38    -91.02                                   
REMARK 500    ASP M1053       31.56   -141.88                                   
REMARK 500    LEU M1065       71.25   -101.13                                   
REMARK 500    LYS M1069       17.59     80.76                                   
REMARK 500    LEU M1140      176.96    178.23                                   
REMARK 500    ASP M1159      -56.78    -25.99                                   
REMARK 500    LYS M1164       75.26     47.04                                   
REMARK 500    ALA M1346      -30.31   -133.23                                   
REMARK 500    LEU M1389      -62.01    -94.38                                   
REMARK 500    VAL M1392      -62.57   -122.60                                   
REMARK 500    GLU R  93      -53.13   -128.56                                   
REMARK 500    VAL R 258      -63.09   -106.45                                   
REMARK 500    ILE S 246      -60.84   -109.94                                   
REMARK 500    VAL S 257      -61.68    -98.45                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS      87 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS                                         
REMARK 500                                                                      
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH          
REMARK 500 CIS AND TRANS CONFORMATION.  CIS BONDS, IF ANY, ARE LISTED           
REMARK 500 ON CISPEP RECORDS.  TRANS IS DEFINED AS 180 +/- 30 AND               
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.                                  
REMARK 500                                 MODEL     OMEGA                      
REMARK 500 CYS M 1067     VAL M 1068                  138.79                    
REMARK 500 ASN M 1344     PRO M 1345                  148.48                    
REMARK 500 ALA T  152     GLU T  153                 -136.49                    
REMARK 500 GLY T  160     LYS T  161                 -126.60                    
REMARK 500 LYS T  161     THR T  162                  141.45                    
REMARK 500 THR T  162     ILE T  163                  139.52                    
REMARK 500 VAL U  222     GLN U  223                 -137.85                    
REMARK 500 LYS V  161     THR V  162                  141.42                    
REMARK 500 THR V  162     ILE V  163                  139.54                    
REMARK 500 PHE W  221     VAL W  222                  131.98                    
REMARK 500 VAL W  222     GLN W  223                 -137.80                    
REMARK 500 ASP X  151     ALA X  152                 -131.00                    
REMARK 500 ALA X  152     GLU X  153                 -147.67                    
REMARK 500 GLY X  160     LYS X  161                 -147.40                    
REMARK 500 LYS X  161     THR X  162                  141.46                    
REMARK 500 THR X  162     ILE X  163                  139.52                    
REMARK 500 PHE Y  206     ALA Y  207                 -147.21                    
REMARK 500 VAL Y  222     GLN Y  223                 -137.80                    
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: MAIN CHAIN PLANARITY                                       
REMARK 500                                                                      
REMARK 500 THE FOLLOWING RESIDUES HAVE A PSEUDO PLANARITY                       
REMARK 500 TORSION ANGLE, C(I) - CA(I) - N(I+1) - O(I), GREATER                 
REMARK 500 10.0 DEGREES. (M=MODEL NUMBER; RES=RESIDUE NAME;                     
REMARK 500 C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;                            
REMARK 500 I=INSERTION CODE).                                                   
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        ANGLE                                           
REMARK 500    SER W 205         13.86                                           
REMARK 500    SER Y 205        -12.22                                           
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 620                                                                      
REMARK 620 METAL COORDINATION                                                   
REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE):                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              ZN S 501  ZN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS S 244   SG                                                     
REMARK 620 2 CYS S 247   SG  138.2                                              
REMARK 620 3 CYS S 264   SG  103.3  82.7                                        
REMARK 620 4 CYS S 268   SG  119.0 102.2  89.2                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              ZN S 502  ZN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS S 256   SG                                                     
REMARK 620 2 CYS S 259   SG   99.1                                              
REMARK 620 3 CYS S 277   SG  149.8 103.6                                        
REMARK 620 N                    1     2                                         
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MG U 503  MG                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 GLU U 297   OE2                                                    
REMARK 620 2 ADP U 502   O2B 172.8                                              
REMARK 620 N                    1                                               
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MG V 502  MG                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 THR V  86   OG1                                                    
REMARK 620 2 ADP V 501   O3B  92.1                                              
REMARK 620 N                    1                                               
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MG W 502  MG                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 GLU W 297   OE2                                                    
REMARK 620 2 ADP W 501   O3B 151.0                                              
REMARK 620 N                    1                                               
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              MG Y 503  MG                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 GLU Y 297   OE2                                                    
REMARK 620 2 ADP Y 502   O2B 139.0                                              
REMARK 620 N                    1                                               
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                             BEF M1602  BE                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 ADP M1601   O1B                                                    
REMARK 620 2 BEF M1602   F1  122.3                                              
REMARK 620 3 BEF M1602   F2   76.4 112.3                                        
REMARK 620 4 BEF M1602   F3  121.8 109.8 107.2                                  
REMARK 620 5 ADP M1601   O3B  90.2  76.5 166.5  77.8                            
REMARK 620 N                    1     2     3     4                             
REMARK 800                                                                      
REMARK 800 SITE                                                                 
REMARK 800 SITE_IDENTIFIER: AC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ADP M 1601                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue BEF M 1602                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue MG M 1603                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ADP R 501                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue BEF R 502                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue MG R 503                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC7                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN S 501                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC8                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN S 502                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC9                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ADP T 501                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue MG U 501                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ADP U 502                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue MG U 503                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ADP V 501                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue MG V 502                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ADP W 501                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD7                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue MG W 502                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD8                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ADP X 501                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD9                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue MG Y 501                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AE1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ADP Y 502                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AE2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue MG Y 503                  
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: EMD-4395   RELATED DB: EMDB                              
REMARK 900 SWR1-NUCLEOSOME COMPLEX AT 3.6 A RESOLUTION                          
REMARK 900 RELATED ID: 6GEJ   RELATED DB: PDB                                   
REMARK 900 SWR1-NUCLEOSOME COMPLEX AT 3.6 A RESOLUTION                          
REMARK 900 RELATED ID: EMD-4396   RELATED DB: EMDB                              
REMARK 900 CHROMATIN REMODELLER-NUCLEOSOME COMPLEX AT 4.5 A RESOLUTION.         
DBREF  6GEN Z   81   211  PDB    6GEN     6GEN            81    211             
DBREF  6GEN A    0   135  UNP    P61830   H3_YEAST         1    136             
DBREF  6GEN B    0   135  UNP    P61830   H3_YEAST         1    136             
DBREF  6GEN C    0   102  UNP    P02309   H4_YEAST         1    103             
DBREF  6GEN D    0   102  UNP    P02309   H4_YEAST         1    103             
DBREF  6GEN E    0   131  UNP    P04911   H2A1_YEAST       1    132             
DBREF  6GEN F    0   131  UNP    P04911   H2A1_YEAST       1    132             
DBREF  6GEN G    0   130  UNP    P02293   H2B1_YEAST       1    131             
DBREF  6GEN H    0   130  UNP    P02293   H2B1_YEAST       1    131             
DBREF  6GEN I  -96    76  PDB    6GEN     6GEN           -96     76             
DBREF  6GEN J  -76    96  PDB    6GEN     6GEN           -76     96             
DBREF  6GEN M    1  1514  UNP    Q05471   SWR1_YEAST       1   1514             
DBREF  6GEN R    1   438  UNP    Q12509   ARP6_YEAST       1    438             
DBREF  6GEN S    1   280  UNP    Q03433   VPS71_YEAST      1    280             
DBREF  6GEN T    1   463  UNP    Q03940   RUVB1_YEAST      1    463             
DBREF  6GEN U    1   471  UNP    Q12464   RUVB2_YEAST      1    471             
DBREF  6GEN V    1   463  UNP    Q03940   RUVB1_YEAST      1    463             
DBREF  6GEN W    1   471  UNP    Q12464   RUVB2_YEAST      1    471             
DBREF  6GEN X    1   463  UNP    Q03940   RUVB1_YEAST      1    463             
DBREF  6GEN Y    1   471  UNP    Q12464   RUVB2_YEAST      1    471             
SEQADV 6GEN GLU A  123  UNP  P61830    ASP   124 CONFLICT                       
SEQADV 6GEN GLU B  123  UNP  P61830    ASP   124 CONFLICT                       
SEQRES   1 Z  131  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES   2 Z  131  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES   3 Z  131  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES   4 Z  131  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES   5 Z  131  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES   6 Z  131  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES   7 Z  131  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES   8 Z  131  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES   9 Z  131  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES  10 Z  131  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES  11 Z  131  UNK                                                          
SEQRES   1 A  136  MET ALA ARG THR LYS GLN THR ALA ARG LYS SER THR GLY          
SEQRES   2 A  136  GLY LYS ALA PRO ARG LYS GLN LEU ALA SER LYS ALA ALA          
SEQRES   3 A  136  ARG LYS SER ALA PRO SER THR GLY GLY VAL LYS LYS PRO          
SEQRES   4 A  136  HIS ARG TYR LYS PRO GLY THR VAL ALA LEU ARG GLU ILE          
SEQRES   5 A  136  ARG ARG PHE GLN LYS SER THR GLU LEU LEU ILE ARG LYS          
SEQRES   6 A  136  LEU PRO PHE GLN ARG LEU VAL ARG GLU ILE ALA GLN ASP          
SEQRES   7 A  136  PHE LYS THR ASP LEU ARG PHE GLN SER SER ALA ILE GLY          
SEQRES   8 A  136  ALA LEU GLN GLU SER VAL GLU ALA TYR LEU VAL SER LEU          
SEQRES   9 A  136  PHE GLU ASP THR ASN LEU ALA ALA ILE HIS ALA LYS ARG          
SEQRES  10 A  136  VAL THR ILE GLN LYS LYS GLU ILE LYS LEU ALA ARG ARG          
SEQRES  11 A  136  LEU ARG GLY GLU ARG SER                                      
SEQRES   1 B  136  MET ALA ARG THR LYS GLN THR ALA ARG LYS SER THR GLY          
SEQRES   2 B  136  GLY LYS ALA PRO ARG LYS GLN LEU ALA SER LYS ALA ALA          
SEQRES   3 B  136  ARG LYS SER ALA PRO SER THR GLY GLY VAL LYS LYS PRO          
SEQRES   4 B  136  HIS ARG TYR LYS PRO GLY THR VAL ALA LEU ARG GLU ILE          
SEQRES   5 B  136  ARG ARG PHE GLN LYS SER THR GLU LEU LEU ILE ARG LYS          
SEQRES   6 B  136  LEU PRO PHE GLN ARG LEU VAL ARG GLU ILE ALA GLN ASP          
SEQRES   7 B  136  PHE LYS THR ASP LEU ARG PHE GLN SER SER ALA ILE GLY          
SEQRES   8 B  136  ALA LEU GLN GLU SER VAL GLU ALA TYR LEU VAL SER LEU          
SEQRES   9 B  136  PHE GLU ASP THR ASN LEU ALA ALA ILE HIS ALA LYS ARG          
SEQRES  10 B  136  VAL THR ILE GLN LYS LYS GLU ILE LYS LEU ALA ARG ARG          
SEQRES  11 B  136  LEU ARG GLY GLU ARG SER                                      
SEQRES   1 C  103  MET SER GLY ARG GLY LYS GLY GLY LYS GLY LEU GLY LYS          
SEQRES   2 C  103  GLY GLY ALA LYS ARG HIS ARG LYS ILE LEU ARG ASP ASN          
SEQRES   3 C  103  ILE GLN GLY ILE THR LYS PRO ALA ILE ARG ARG LEU ALA          
SEQRES   4 C  103  ARG ARG GLY GLY VAL LYS ARG ILE SER GLY LEU ILE TYR          
SEQRES   5 C  103  GLU GLU VAL ARG ALA VAL LEU LYS SER PHE LEU GLU SER          
SEQRES   6 C  103  VAL ILE ARG ASP SER VAL THR TYR THR GLU HIS ALA LYS          
SEQRES   7 C  103  ARG LYS THR VAL THR SER LEU ASP VAL VAL TYR ALA LEU          
SEQRES   8 C  103  LYS ARG GLN GLY ARG THR LEU TYR GLY PHE GLY GLY              
SEQRES   1 D  103  MET SER GLY ARG GLY LYS GLY GLY LYS GLY LEU GLY LYS          
SEQRES   2 D  103  GLY GLY ALA LYS ARG HIS ARG LYS ILE LEU ARG ASP ASN          
SEQRES   3 D  103  ILE GLN GLY ILE THR LYS PRO ALA ILE ARG ARG LEU ALA          
SEQRES   4 D  103  ARG ARG GLY GLY VAL LYS ARG ILE SER GLY LEU ILE TYR          
SEQRES   5 D  103  GLU GLU VAL ARG ALA VAL LEU LYS SER PHE LEU GLU SER          
SEQRES   6 D  103  VAL ILE ARG ASP SER VAL THR TYR THR GLU HIS ALA LYS          
SEQRES   7 D  103  ARG LYS THR VAL THR SER LEU ASP VAL VAL TYR ALA LEU          
SEQRES   8 D  103  LYS ARG GLN GLY ARG THR LEU TYR GLY PHE GLY GLY              
SEQRES   1 E  132  MET SER GLY GLY LYS GLY GLY LYS ALA GLY SER ALA ALA          
SEQRES   2 E  132  LYS ALA SER GLN SER ARG SER ALA LYS ALA GLY LEU THR          
SEQRES   3 E  132  PHE PRO VAL GLY ARG VAL HIS ARG LEU LEU ARG ARG GLY          
SEQRES   4 E  132  ASN TYR ALA GLN ARG ILE GLY SER GLY ALA PRO VAL TYR          
SEQRES   5 E  132  LEU THR ALA VAL LEU GLU TYR LEU ALA ALA GLU ILE LEU          
SEQRES   6 E  132  GLU LEU ALA GLY ASN ALA ALA ARG ASP ASN LYS LYS THR          
SEQRES   7 E  132  ARG ILE ILE PRO ARG HIS LEU GLN LEU ALA ILE ARG ASN          
SEQRES   8 E  132  ASP ASP GLU LEU ASN LYS LEU LEU GLY ASN VAL THR ILE          
SEQRES   9 E  132  ALA GLN GLY GLY VAL LEU PRO ASN ILE HIS GLN ASN LEU          
SEQRES  10 E  132  LEU PRO LYS LYS SER ALA LYS ALA THR LYS ALA SER GLN          
SEQRES  11 E  132  GLU LEU                                                      
SEQRES   1 F  132  MET SER GLY GLY LYS GLY GLY LYS ALA GLY SER ALA ALA          
SEQRES   2 F  132  LYS ALA SER GLN SER ARG SER ALA LYS ALA GLY LEU THR          
SEQRES   3 F  132  PHE PRO VAL GLY ARG VAL HIS ARG LEU LEU ARG ARG GLY          
SEQRES   4 F  132  ASN TYR ALA GLN ARG ILE GLY SER GLY ALA PRO VAL TYR          
SEQRES   5 F  132  LEU THR ALA VAL LEU GLU TYR LEU ALA ALA GLU ILE LEU          
SEQRES   6 F  132  GLU LEU ALA GLY ASN ALA ALA ARG ASP ASN LYS LYS THR          
SEQRES   7 F  132  ARG ILE ILE PRO ARG HIS LEU GLN LEU ALA ILE ARG ASN          
SEQRES   8 F  132  ASP ASP GLU LEU ASN LYS LEU LEU GLY ASN VAL THR ILE          
SEQRES   9 F  132  ALA GLN GLY GLY VAL LEU PRO ASN ILE HIS GLN ASN LEU          
SEQRES  10 F  132  LEU PRO LYS LYS SER ALA LYS ALA THR LYS ALA SER GLN          
SEQRES  11 F  132  GLU LEU                                                      
SEQRES   1 G  131  MET SER ALA LYS ALA GLU LYS LYS PRO ALA SER LYS ALA          
SEQRES   2 G  131  PRO ALA GLU LYS LYS PRO ALA ALA LYS LYS THR SER THR          
SEQRES   3 G  131  SER THR ASP GLY LYS LYS ARG SER LYS ALA ARG LYS GLU          
SEQRES   4 G  131  THR TYR SER SER TYR ILE TYR LYS VAL LEU LYS GLN THR          
SEQRES   5 G  131  HIS PRO ASP THR GLY ILE SER GLN LYS SER MET SER ILE          
SEQRES   6 G  131  LEU ASN SER PHE VAL ASN ASP ILE PHE GLU ARG ILE ALA          
SEQRES   7 G  131  THR GLU ALA SER LYS LEU ALA ALA TYR ASN LYS LYS SER          
SEQRES   8 G  131  THR ILE SER ALA ARG GLU ILE GLN THR ALA VAL ARG LEU          
SEQRES   9 G  131  ILE LEU PRO GLY GLU LEU ALA LYS HIS ALA VAL SER GLU          
SEQRES  10 G  131  GLY THR ARG ALA VAL THR LYS TYR SER SER SER THR GLN          
SEQRES  11 G  131  ALA                                                          
SEQRES   1 H  131  MET SER ALA LYS ALA GLU LYS LYS PRO ALA SER LYS ALA          
SEQRES   2 H  131  PRO ALA GLU LYS LYS PRO ALA ALA LYS LYS THR SER THR          
SEQRES   3 H  131  SER THR ASP GLY LYS LYS ARG SER LYS ALA ARG LYS GLU          
SEQRES   4 H  131  THR TYR SER SER TYR ILE TYR LYS VAL LEU LYS GLN THR          
SEQRES   5 H  131  HIS PRO ASP THR GLY ILE SER GLN LYS SER MET SER ILE          
SEQRES   6 H  131  LEU ASN SER PHE VAL ASN ASP ILE PHE GLU ARG ILE ALA          
SEQRES   7 H  131  THR GLU ALA SER LYS LEU ALA ALA TYR ASN LYS LYS SER          
SEQRES   8 H  131  THR ILE SER ALA ARG GLU ILE GLN THR ALA VAL ARG LEU          
SEQRES   9 H  131  ILE LEU PRO GLY GLU LEU ALA LYS HIS ALA VAL SER GLU          
SEQRES  10 H  131  GLY THR ARG ALA VAL THR LYS TYR SER SER SER THR GLN          
SEQRES  11 H  131  ALA                                                          
SEQRES   1 I  173   DG  DC  DA  DT  DT  DA  DA  DT  DG  DC  DA  DT  DC          
SEQRES   2 I  173   DC  DG  DC  DG  DG  DC  DC  DG  DC  DC  DC  DT  DG          
SEQRES   3 I  173   DG  DA  DG  DA  DA  DT  DC  DC  DC  DG  DG  DT  DG          
SEQRES   4 I  173   DC  DC  DG  DA  DG  DG  DC  DC  DG  DC  DT  DC  DA          
SEQRES   5 I  173   DA  DT  DT  DG  DG  DT  DC  DG  DT  DA  DG  DA  DC          
SEQRES   6 I  173   DA  DG  DC  DT  DC  DT  DA  DG  DC  DA  DC  DC  DG          
SEQRES   7 I  173   DC  DT  DT  DA  DA  DA  DC  DG  DC  DA  DC  DG  DT          
SEQRES   8 I  173   DA  DC  DG  DC  DG  DC  DT  DG  DT  DC  DC  DC  DC          
SEQRES   9 I  173   DC  DG  DC  DG  DT  DT  DT  DT  DA  DA  DC  DC  DG          
SEQRES  10 I  173   DC  DC  DA  DA  DG  DG  DG  DG  DA  DT  DT  DA  DC          
SEQRES  11 I  173   DT  DC  DC  DC  DT  DA  DG  DT  DC  DT  DC  DC  DA          
SEQRES  12 I  173   DG  DG  DC  DA  DC  DG  DT  DG  DT  DC  DA  DG  DA          
SEQRES  13 I  173   DT  DA  DT  DA  DT  DA  DC  DA  DT  DC  DC  DT  DG          
SEQRES  14 I  173   DT  DG  DC  DA                                              
SEQRES   1 J  173   DT  DG  DC  DA  DC  DA  DG  DG  DA  DT  DG  DT  DA          
SEQRES   2 J  173   DT  DA  DT  DA  DT  DC  DT  DG  DA  DC  DA  DC  DG          
SEQRES   3 J  173   DT  DG  DC  DC  DT  DG  DG  DA  DG  DA  DC  DT  DA          
SEQRES   4 J  173   DG  DG  DG  DA  DG  DT  DA  DA  DT  DC  DC  DC  DC          
SEQRES   5 J  173   DT  DT  DG  DG  DC  DG  DG  DT  DT  DA  DA  DA  DA          
SEQRES   6 J  173   DC  DG  DC  DG  DG  DG  DG  DG  DA  DC  DA  DG  DC          
SEQRES   7 J  173   DG  DC  DG  DT  DA  DC  DG  DT  DG  DC  DG  DT  DT          
SEQRES   8 J  173   DT  DA  DA  DG  DC  DG  DG  DT  DG  DC  DT  DA  DG          
SEQRES   9 J  173   DA  DG  DC  DT  DG  DT  DC  DT  DA  DC  DG  DA  DC          
SEQRES  10 J  173   DC  DA  DA  DT  DT  DG  DA  DG  DC  DG  DG  DC  DC          
SEQRES  11 J  173   DT  DC  DG  DG  DC  DA  DC  DC  DG  DG  DG  DA  DT          
SEQRES  12 J  173   DT  DC  DT  DC  DC  DA  DG  DG  DG  DC  DG  DG  DC          
SEQRES  13 J  173   DC  DG  DC  DG  DG  DA  DT  DG  DC  DA  DT  DT  DA          
SEQRES  14 J  173   DA  DT  DG  DC                                              
SEQRES   1 M 1514  MET THR THR SER ARG LYS SER HIS ALA LYS ASP LYS LYS          
SEQRES   2 M 1514  ALA GLY GLY GLU GLN ASP LEU ALA ASP LEU LYS PHE ARG          
SEQRES   3 M 1514  TYR ASP LEU LEU THR ASN GLU LEU PHE HIS LEU ARG GLU          
SEQRES   4 M 1514  PHE VAL SER LEU VAL ASP TYR ASP PRO THR HIS PHE ASN          
SEQRES   5 M 1514  ASP SER GLU SER PHE GLN LYS PHE LEU ARG GLU THR HIS          
SEQRES   6 M 1514  LEU SER LEU GLU GLU ARG GLY GLU LYS PHE THR ASP ASP          
SEQRES   7 M 1514  VAL ALA LYS LYS GLY THR ASN GLY ASP LEU THR ARG ARG          
SEQRES   8 M 1514  ARG ARG ASN LEU ARG THR SER THR VAL VAL SER SER GLU          
SEQRES   9 M 1514  THR THR ASN GLU LYS LYS GLY ASP ILE GLU LEU LYS LEU          
SEQRES  10 M 1514  GLU SER ILE ALA PRO LEU VAL ARG ASN LYS CYS GLU GLU          
SEQRES  11 M 1514  LEU LYS TYR LYS LEU SER ASP HIS SER ASN ARG LYS SER          
SEQRES  12 M 1514  ILE VAL PRO GLN LYS ARG PRO ILE GLN HIS LEU LYS LYS          
SEQRES  13 M 1514  ARG GLU ALA ALA LYS SER LEU LYS PHE LYS SER GLU ARG          
SEQRES  14 M 1514  LYS GLU ASN PRO LEU PRO LEU HIS GLU HIS ILE ALA GLU          
SEQRES  15 M 1514  GLU ARG TYR ASP HIS ILE ALA LYS VAL GLU GLU PRO SER          
SEQRES  16 M 1514  GLU ALA PHE THR ILE LYS CYS PRO SER ASP ASP SER SER          
SEQRES  17 M 1514  PHE GLU ASN THR SER GLU HIS TYR SER ASP ASN PHE TYR          
SEQRES  18 M 1514  PHE THR THR SER SER GLU GLU GLU ASP ILE LYS LYS LYS          
SEQRES  19 M 1514  ARG GLY ARG LYS LYS LYS LYS PRO ARG ILE LYS LEU VAL          
SEQRES  20 M 1514  VAL HIS PRO PRO LYS GLN THR ILE THR ASN PRO LEU HIS          
SEQRES  21 M 1514  VAL VAL LYS PRO GLY TYR GLU SER LEU HIS GLU TYR ILE          
SEQRES  22 M 1514  ALA SER PHE LYS SER LEU GLU ASP ASP LEU THR LEU GLU          
SEQRES  23 M 1514  GLU TYR ASN LYS TYR ILE ASP GLU GLN ARG ARG LEU LEU          
SEQRES  24 M 1514  SER ARG LEU LYS LYS GLY ILE GLU ASN GLY ALA LEU LYS          
SEQRES  25 M 1514  TYR ASP LYS GLU THR ASP SER LEU GLN PRO ILE THR SER          
SEQRES  26 M 1514  LYS GLU ILE LYS THR ILE ILE THR TYR LYS PRO ASP PRO          
SEQRES  27 M 1514  ILE SER TYR PHE TYR LYS GLN GLN ASP LEU GLN ILE HIS          
SEQRES  28 M 1514  THR ASP HIS LEU ILE ASN GLN GLY ILE HIS MET SER LYS          
SEQRES  29 M 1514  LEU PHE ARG SER SER THR LYS ALA ARG ILE ALA ARG ALA          
SEQRES  30 M 1514  LYS LYS VAL SER GLN MET ILE GLU GLN HIS PHE LYS HIS          
SEQRES  31 M 1514  VAL ALA GLY ALA GLU GLU ARG LYS ALA LYS GLU GLU GLU          
SEQRES  32 M 1514  ARG HIS LYS LYS SER LEU ALA ARG PHE ALA VAL GLN ALA          
SEQRES  33 M 1514  VAL LYS LYS ARG TRP ASN MET ALA GLU LYS ALA TYR ARG          
SEQRES  34 M 1514  ILE LEU ARG LYS ASP GLU GLU GLU GLN LEU LYS ARG ILE          
SEQRES  35 M 1514  GLU GLY LYS GLN HIS LEU SER LYS MET LEU GLU LYS SER          
SEQRES  36 M 1514  THR GLN LEU LEU GLU ALA GLN LEU ASN GLN VAL ASN ASP          
SEQRES  37 M 1514  ASP GLY ARG SER SER THR PRO SER SER ASP SER ASN ASP          
SEQRES  38 M 1514  VAL LEU SER GLU SER ASP ASP ASP MET ASP ASP GLU LEU          
SEQRES  39 M 1514  SER THR SER SER ASP GLU ASP GLU GLU VAL ASP ALA ASP          
SEQRES  40 M 1514  VAL GLY LEU GLU ASN SER PRO ALA SER THR GLU ALA THR          
SEQRES  41 M 1514  PRO THR ASP GLU SER LEU ASN LEU ILE GLN LEU LYS GLU          
SEQRES  42 M 1514  LYS TYR GLY HIS PHE ASN GLY SER SER THR VAL TYR ASP          
SEQRES  43 M 1514  SER ARG ASN LYS ASP GLU LYS PHE PRO THR LEU ASP LYS          
SEQRES  44 M 1514  HIS GLU SER SER SER SER GLU SER SER VAL MET THR GLY          
SEQRES  45 M 1514  GLU GLU SER SER ILE TYR SER SER SER GLU ASN GLU SER          
SEQRES  46 M 1514  GLN ASN GLU ASN ASP ARG GLU SER ASP ASP LYS THR PRO          
SEQRES  47 M 1514  SER VAL GLY LEU SER ALA LEU PHE GLY LYS GLY GLU GLU          
SEQRES  48 M 1514  SER ASP GLY ASP LEU ASP LEU ASP ASP SER GLU ASP PHE          
SEQRES  49 M 1514  THR VAL ASN SER SER SER VAL GLU GLY GLU GLU LEU GLU          
SEQRES  50 M 1514  LYS ASP GLN VAL ASP ASN SER ALA ALA THR PHE GLU ARG          
SEQRES  51 M 1514  ALA GLY ASP PHE VAL HIS THR GLN ASN GLU ASN ARG ASP          
SEQRES  52 M 1514  ASP ILE LYS ASP VAL GLU GLU ASP ALA GLU THR LYS VAL          
SEQRES  53 M 1514  GLN GLU GLU GLN LEU SER VAL VAL ASP VAL PRO VAL PRO          
SEQRES  54 M 1514  SER LEU LEU ARG GLY ASN LEU ARG THR TYR GLN LYS GLN          
SEQRES  55 M 1514  GLY LEU ASN TRP LEU ALA SER LEU TYR ASN ASN HIS THR          
SEQRES  56 M 1514  ASN GLY ILE LEU ALA ASP GLU MET GLY LEU GLY LYS THR          
SEQRES  57 M 1514  ILE GLN THR ILE SER LEU LEU ALA TYR LEU ALA CYS GLU          
SEQRES  58 M 1514  LYS GLU ASN TRP GLY PRO HIS LEU ILE VAL VAL PRO THR          
SEQRES  59 M 1514  SER VAL LEU LEU ASN TRP GLU MET GLU PHE LYS ARG PHE          
SEQRES  60 M 1514  ALA PRO GLY PHE LYS VAL LEU THR TYR TYR GLY SER PRO          
SEQRES  61 M 1514  GLN GLN ARG LYS GLU LYS ARG LYS GLY TRP ASN LYS PRO          
SEQRES  62 M 1514  ASP ALA PHE HIS VAL CYS ILE VAL SER TYR GLN LEU VAL          
SEQRES  63 M 1514  VAL GLN ASP GLN HIS SER PHE LYS ARG LYS ARG TRP GLN          
SEQRES  64 M 1514  TYR MET VAL LEU ASP GLU ALA HIS ASN ILE LYS ASN PHE          
SEQRES  65 M 1514  ARG SER THR ARG TRP GLN ALA LEU LEU ASN PHE ASN THR          
SEQRES  66 M 1514  GLN ARG ARG LEU LEU LEU THR GLY THR PRO LEU GLN ASN          
SEQRES  67 M 1514  ASN LEU ALA GLU LEU TRP SER LEU LEU TYR PHE LEU MET          
SEQRES  68 M 1514  PRO GLN THR VAL ILE ASP GLY LYS LYS VAL SER GLY PHE          
SEQRES  69 M 1514  ALA ASP LEU ASP ALA PHE GLN GLN TRP PHE GLY ARG PRO          
SEQRES  70 M 1514  VAL ASP LYS ILE ILE GLU THR GLY GLN ASN PHE GLY GLN          
SEQRES  71 M 1514  ASP LYS GLU THR LYS LYS THR VAL ALA LYS LEU HIS GLN          
SEQRES  72 M 1514  VAL LEU ARG PRO TYR LEU LEU ARG ARG LEU LYS ALA ASP          
SEQRES  73 M 1514  VAL GLU LYS GLN MET PRO ALA LYS TYR GLU HIS ILE VAL          
SEQRES  74 M 1514  TYR CYS LYS LEU SER LYS ARG GLN ARG PHE LEU TYR ASP          
SEQRES  75 M 1514  ASP PHE MET SER ARG ALA GLN THR LYS ALA THR LEU ALA          
SEQRES  76 M 1514  SER GLY ASN PHE MET SER ILE VAL ASN CYS LEU MET GLN          
SEQRES  77 M 1514  LEU ARG LYS VAL CYS ASN HIS PRO ASN LEU PHE GLU VAL          
SEQRES  78 M 1514  ARG PRO ILE LEU THR SER PHE VAL LEU GLU HIS CYS VAL          
SEQRES  79 M 1514  ALA SER ASP TYR LYS ASP VAL GLU ARG THR LEU LEU LYS          
SEQRES  80 M 1514  LEU PHE LYS LYS ASN ASN GLN VAL ASN ARG VAL ASP LEU          
SEQRES  81 M 1514  ASP PHE LEU ASN LEU VAL PHE THR LEU ASN ASP LYS ASP          
SEQRES  82 M 1514  LEU THR SER TYR HIS ALA GLU GLU ILE SER LYS LEU THR          
SEQRES  83 M 1514  CYS VAL LYS ASN PHE VAL GLU GLU VAL ASN LYS LEU ARG          
SEQRES  84 M 1514  GLU THR ASN LYS GLN LEU GLN GLU GLU PHE GLY GLU ALA          
SEQRES  85 M 1514  SER PHE LEU ASN PHE GLN ASP ALA ASN GLN TYR PHE LYS          
SEQRES  86 M 1514  TYR SER ASN LYS GLN LYS LEU GLU GLY THR VAL ASP MET          
SEQRES  87 M 1514  LEU ASN PHE LEU LYS MET VAL ASN LYS LEU ARG CYS ASP          
SEQRES  88 M 1514  ARG ARG PRO ILE PHE GLY LYS ASN LEU ILE ASP LEU LEU          
SEQRES  89 M 1514  THR LYS ASP ARG ARG VAL LYS TYR ASP LYS SER SER ILE          
SEQRES  90 M 1514  ILE ASP ASN GLU LEU ILE LYS PRO LEU GLN THR ARG VAL          
SEQRES  91 M 1514  LEU ASP ASN ARG LYS ILE ILE ASP THR PHE ALA VAL LEU          
SEQRES  92 M 1514  THR PRO SER ALA VAL SER LEU ASP MET ARG LYS LEU ALA          
SEQRES  93 M 1514  LEU GLY LEU ASN ASP ASP SER SER VAL GLY GLU ASN THR          
SEQRES  94 M 1514  ARG LEU LYS VAL MET GLN ASN CYS PHE GLU VAL SER ASN          
SEQRES  95 M 1514  PRO LEU HIS GLN LEU GLN THR LYS LEU THR ILE ALA PHE          
SEQRES  96 M 1514  PRO ASP LYS SER LEU LEU GLN TYR ASP CYS GLY LYS LEU          
SEQRES  97 M 1514  GLN LYS LEU ALA ILE LEU LEU GLN GLN LEU LYS ASP ASN          
SEQRES  98 M 1514  GLY HIS ARG ALA LEU ILE PHE THR GLN MET THR LYS VAL          
SEQRES  99 M 1514  LEU ASP VAL LEU GLU GLN PHE LEU ASN TYR HIS GLY TYR          
SEQRES 100 M 1514  LEU TYR MET ARG LEU ASP GLY ALA THR LYS ILE GLU ASP          
SEQRES 101 M 1514  ARG GLN ILE LEU THR GLU ARG PHE ASN THR ASP SER ARG          
SEQRES 102 M 1514  ILE THR VAL PHE ILE LEU SER SER ARG SER GLY GLY LEU          
SEQRES 103 M 1514  GLY ILE ASN LEU THR GLY ALA ASP THR VAL ILE PHE TYR          
SEQRES 104 M 1514  ASP SER ASP TRP ASN PRO ALA MET ASP LYS GLN CYS GLN          
SEQRES 105 M 1514  ASP ARG CYS HIS ARG ILE GLY GLN THR ARG ASP VAL HIS          
SEQRES 106 M 1514  ILE TYR ARG PHE VAL SER GLU HIS THR ILE GLU SER ASN          
SEQRES 107 M 1514  ILE LEU LYS LYS ALA ASN GLN LYS ARG GLN LEU ASP ASN          
SEQRES 108 M 1514  VAL VAL ILE GLN GLU GLY ASP PHE THR THR ASP TYR PHE          
SEQRES 109 M 1514  SER LYS LEU SER VAL ARG ASP LEU LEU GLY SER GLU LEU          
SEQRES 110 M 1514  PRO GLU ASN ALA SER GLY GLY ASP LYS PRO LEU ILE ALA          
SEQRES 111 M 1514  ASP ALA ASP VAL ALA ALA LYS ASP PRO ARG GLN LEU GLU          
SEQRES 112 M 1514  ARG LEU LEU ALA GLN ALA GLU ASP GLU ASP ASP VAL LYS          
SEQRES 113 M 1514  ALA ALA ASN LEU ALA MET ARG GLU VAL GLU ILE ASP ASN          
SEQRES 114 M 1514  ASP ASP PHE ASP GLU SER THR GLU LYS LYS ALA ALA ASN          
SEQRES 115 M 1514  GLU GLU GLU GLU ASN HIS ALA GLU LEU ASP GLU TYR GLU          
SEQRES 116 M 1514  GLY THR ALA HIS VAL ASP GLU TYR MET ILE ARG PHE ILE          
SEQRES 117 M 1514  ALA ASN GLY TYR TYR TYR                                      
SEQRES   1 R  438  MET GLU THR PRO PRO ILE VAL ILE ASP ASN GLY SER TYR          
SEQRES   2 R  438  GLU ILE LYS PHE GLY PRO SER THR ASN LYS LYS PRO PHE          
SEQRES   3 R  438  ARG ALA LEU ASN ALA LEU ALA LYS ASP LYS PHE GLY THR          
SEQRES   4 R  438  SER TYR LEU SER ASN HIS ILE LYS ASN ILE LYS ASP ILE          
SEQRES   5 R  438  SER SER ILE THR PHE ARG ARG PRO HIS GLU LEU GLY GLN          
SEQRES   6 R  438  LEU THR LEU TRP GLU LEU GLU SER CYS ILE TRP ASP TYR          
SEQRES   7 R  438  CYS LEU PHE ASN PRO SER GLU PHE ASP GLY PHE ASP LEU          
SEQRES   8 R  438  LYS GLU GLY LYS GLY HIS HIS LEU VAL ALA SER GLU SER          
SEQRES   9 R  438  CYS MET THR LEU PRO GLU LEU SER LYS HIS ALA ASP GLN          
SEQRES  10 R  438  VAL ILE PHE GLU GLU TYR GLU PHE ASP SER LEU PHE LYS          
SEQRES  11 R  438  SER PRO VAL ALA VAL PHE VAL PRO PHE THR LYS SER TYR          
SEQRES  12 R  438  LYS GLY GLU MET ARG THR ILE SER GLY LYS ASP GLU ASP          
SEQRES  13 R  438  ILE ASP ILE VAL ARG GLY ASN SER ASP SER THR ASN SER          
SEQRES  14 R  438  THR SER SER GLU SER LYS ASN ALA GLN ASP SER GLY SER          
SEQRES  15 R  438  ASP TYR HIS ASP PHE GLN LEU VAL ILE ASP SER GLY PHE          
SEQRES  16 R  438  ASN CYS THR TRP ILE ILE PRO VAL LEU LYS GLY ILE PRO          
SEQRES  17 R  438  TYR TYR LYS ALA VAL LYS LYS LEU ASP ILE GLY GLY ARG          
SEQRES  18 R  438  PHE LEU THR GLY LEU LEU LYS GLU THR LEU SER PHE ARG          
SEQRES  19 R  438  HIS TYR ASN MET MET ASP GLU THR ILE LEU VAL ASN ASN          
SEQRES  20 R  438  ILE LYS GLU GLN CYS LEU PHE VAL SER PRO VAL SER TYR          
SEQRES  21 R  438  PHE ASP SER PHE LYS THR LYS ASP LYS HIS ALA LEU GLU          
SEQRES  22 R  438  TYR VAL LEU PRO ASP PHE GLN THR SER PHE LEU GLY TYR          
SEQRES  23 R  438  VAL ARG ASN PRO ARG LYS GLU ASN VAL PRO LEU PRO GLU          
SEQRES  24 R  438  ASP ALA GLN ILE ILE THR LEU THR ASP GLU LEU PHE THR          
SEQRES  25 R  438  ILE PRO GLU THR PHE PHE HIS PRO GLU ILE SER GLN ILE          
SEQRES  26 R  438  THR LYS PRO GLY ILE VAL GLU ALA ILE LEU GLU SER LEU          
SEQRES  27 R  438  SER MET LEU PRO GLU ILE VAL ARG PRO LEU MET VAL GLY          
SEQRES  28 R  438  ASN ILE VAL CYS THR GLY GLY ASN PHE ASN LEU PRO ASN          
SEQRES  29 R  438  PHE ALA GLN ARG LEU ALA ALA GLU LEU GLN ARG GLN LEU          
SEQRES  30 R  438  PRO THR ASP TRP THR CYS HIS VAL SER VAL PRO GLU GLY          
SEQRES  31 R  438  ASP CYS ALA LEU PHE GLY TRP GLU VAL MET SER GLN PHE          
SEQRES  32 R  438  ALA LYS THR ASP SER TYR ARG LYS ALA ARG VAL THR ARG          
SEQRES  33 R  438  GLU GLU TYR TYR GLU HIS GLY PRO ASP TRP CYS THR LYS          
SEQRES  34 R  438  HIS ARG PHE GLY TYR GLN ASN TRP ILE                          
SEQRES   1 S  280  MET LYS ALA LEU VAL GLU GLU ILE ASP LYS LYS THR TYR          
SEQRES   2 S  280  ASN PRO ASP ILE TYR PHE THR SER LEU ASP PRO GLN ALA          
SEQRES   3 S  280  ARG ARG TYR THR SER LYS LYS ILE ASN LYS GLN GLY THR          
SEQRES   4 S  280  ILE SER THR SER ARG PRO VAL LYS ARG ILE ASN TYR SER          
SEQRES   5 S  280  LEU ALA ASP LEU GLU ALA ARG LEU TYR THR SER ARG SER          
SEQRES   6 S  280  GLU GLY ASP GLY ASN SER ILE SER ARG GLN ASP ASP ARG          
SEQRES   7 S  280  ASN SER LYS ASN SER HIS SER PHE GLU GLU ARG TYR THR          
SEQRES   8 S  280  GLN GLN GLU ILE LEU GLN SER ASP ARG ARG PHE MET GLU          
SEQRES   9 S  280  LEU ASN THR GLU ASN PHE SER ASP LEU PRO ASN VAL PRO          
SEQRES  10 S  280  THR LEU LEU SER ASP LEU THR GLY VAL PRO ARG ASP ARG          
SEQRES  11 S  280  ILE GLU SER THR THR LYS PRO ILE SER GLN THR SER ASP          
SEQRES  12 S  280  GLY LEU SER ALA LEU MET GLY GLY SER SER PHE VAL LYS          
SEQRES  13 S  280  GLU HIS SER LYS TYR GLY HIS GLY TRP VAL LEU LYS PRO          
SEQRES  14 S  280  GLU THR LEU ARG GLU ILE GLN LEU SER TYR LYS SER THR          
SEQRES  15 S  280  LYS LEU PRO LYS PRO LYS ARG LYS ASN THR ASN ARG ILE          
SEQRES  16 S  280  VAL ALA LEU LYS LYS VAL LEU SER SER LYS ARG ASN LEU          
SEQRES  17 S  280  HIS SER PHE LEU ASP SER ALA LEU LEU ASN LEU MET ASP          
SEQRES  18 S  280  LYS ASN VAL ILE TYR HIS ASN VAL TYR ASN LYS ARG TYR          
SEQRES  19 S  280  PHE LYS VAL LEU PRO LEU ILE THR THR CYS SER ILE CYS          
SEQRES  20 S  280  GLY GLY TYR ASP SER ILE SER SER CYS VAL ASN CYS GLY          
SEQRES  21 S  280  ASN LYS ILE CYS SER VAL SER CYS PHE LYS LEU HIS ASN          
SEQRES  22 S  280  GLU THR ARG CYS ARG ASN ARG                                  
SEQRES   1 T  463  MET VAL ALA ILE SER GLU VAL LYS GLU ASN PRO GLY VAL          
SEQRES   2 T  463  ASN SER SER ASN SER GLY ALA VAL THR ARG THR ALA ALA          
SEQRES   3 T  463  HIS THR HIS ILE LYS GLY LEU GLY LEU ASP GLU SER GLY          
SEQRES   4 T  463  VAL ALA LYS ARG VAL GLU GLY GLY PHE VAL GLY GLN ILE          
SEQRES   5 T  463  GLU ALA ARG GLU ALA CYS GLY VAL ILE VAL ASP LEU ILE          
SEQRES   6 T  463  LYS ALA LYS LYS MET SER GLY ARG ALA ILE LEU LEU ALA          
SEQRES   7 T  463  GLY GLY PRO SER THR GLY LYS THR ALA LEU ALA LEU ALA          
SEQRES   8 T  463  ILE SER GLN GLU LEU GLY PRO LYS VAL PRO PHE CYS PRO          
SEQRES   9 T  463  LEU VAL GLY SER GLU LEU TYR SER VAL GLU VAL LYS LYS          
SEQRES  10 T  463  THR GLU THR LEU MET GLU ASN PHE ARG ARG ALA ILE GLY          
SEQRES  11 T  463  LEU ARG ILE LYS GLU THR LYS GLU VAL TYR GLU GLY GLU          
SEQRES  12 T  463  VAL THR GLU LEU THR PRO GLU ASP ALA GLU ASN PRO LEU          
SEQRES  13 T  463  GLY GLY TYR GLY LYS THR ILE SER HIS VAL ILE VAL GLY          
SEQRES  14 T  463  LEU LYS SER ALA LYS GLY THR LYS THR LEU ARG LEU ASP          
SEQRES  15 T  463  PRO THR ILE TYR GLU SER ILE GLN ARG GLU LYS VAL SER          
SEQRES  16 T  463  ILE GLY ASP VAL ILE TYR ILE GLU ALA ASN THR GLY ALA          
SEQRES  17 T  463  VAL LYS ARG VAL GLY ARG SER ASP ALA TYR ALA THR GLU          
SEQRES  18 T  463  PHE ASP LEU GLU THR GLU GLU TYR VAL PRO LEU PRO LYS          
SEQRES  19 T  463  GLY GLU VAL HIS LYS LYS LYS GLU ILE VAL GLN ASP VAL          
SEQRES  20 T  463  THR LEU HIS ASP LEU ASP VAL ALA ASN ALA ARG PRO GLN          
SEQRES  21 T  463  GLY GLY GLN ASP VAL ILE SER MET MET GLY GLN LEU LEU          
SEQRES  22 T  463  LYS PRO LYS LYS THR GLU ILE THR GLU LYS LEU ARG GLN          
SEQRES  23 T  463  GLU VAL ASN LYS VAL VAL ALA LYS TYR ILE ASP GLN GLY          
SEQRES  24 T  463  VAL ALA GLU LEU ILE PRO GLY VAL LEU PHE ILE ASP GLU          
SEQRES  25 T  463  VAL ASN MET LEU ASP ILE GLU ILE PHE THR TYR LEU ASN          
SEQRES  26 T  463  LYS ALA LEU GLU SER ASN ILE ALA PRO VAL VAL VAL LEU          
SEQRES  27 T  463  ALA SER ASN ARG GLY MET THR THR VAL ARG GLY THR GLU          
SEQRES  28 T  463  ASP VAL ILE SER PRO HIS GLY VAL PRO PRO ASP LEU ILE          
SEQRES  29 T  463  ASP ARG LEU LEU ILE VAL ARG THR LEU PRO TYR ASP LYS          
SEQRES  30 T  463  ASP GLU ILE ARG THR ILE ILE GLU ARG ARG ALA THR VAL          
SEQRES  31 T  463  GLU ARG LEU GLN VAL GLU SER SER ALA LEU ASP LEU LEU          
SEQRES  32 T  463  ALA THR MET GLY THR GLU THR SER LEU ARG TYR ALA LEU          
SEQRES  33 T  463  GLN LEU LEU ALA PRO CYS GLY ILE LEU ALA GLN THR SER          
SEQRES  34 T  463  ASN ARG LYS GLU ILE VAL VAL ASN ASP VAL ASN GLU ALA          
SEQRES  35 T  463  LYS LEU LEU PHE LEU ASP ALA LYS ARG SER THR LYS ILE          
SEQRES  36 T  463  LEU GLU THR SER ALA ASN TYR LEU                              
SEQRES   1 U  471  MET SER ILE GLN THR SER ASP PRO ASN GLU THR SER ASP          
SEQRES   2 U  471  LEU LYS SER LEU SER LEU ILE ALA ALA HIS SER HIS ILE          
SEQRES   3 U  471  THR GLY LEU GLY LEU ASP GLU ASN LEU GLN PRO ARG PRO          
SEQRES   4 U  471  THR SER GLU GLY MET VAL GLY GLN LEU GLN ALA ARG ARG          
SEQRES   5 U  471  ALA ALA GLY VAL ILE LEU LYS MET VAL GLN ASN GLY THR          
SEQRES   6 U  471  ILE ALA GLY ARG ALA VAL LEU VAL ALA GLY PRO PRO SER          
SEQRES   7 U  471  THR GLY LYS THR ALA LEU ALA MET GLY VAL SER GLN SER          
SEQRES   8 U  471  LEU GLY LYS ASP VAL PRO PHE THR ALA ILE ALA GLY SER          
SEQRES   9 U  471  GLU ILE PHE SER LEU GLU LEU SER LYS THR GLU ALA LEU          
SEQRES  10 U  471  THR GLN ALA PHE ARG LYS SER ILE GLY ILE LYS ILE LYS          
SEQRES  11 U  471  GLU GLU THR GLU LEU ILE GLU GLY GLU VAL VAL GLU ILE          
SEQRES  12 U  471  GLN ILE ASP ARG SER ILE THR GLY GLY HIS LYS GLN GLY          
SEQRES  13 U  471  LYS LEU THR ILE LYS THR THR ASP MET GLU THR ILE TYR          
SEQRES  14 U  471  GLU LEU GLY ASN LYS MET ILE ASP GLY LEU THR LYS GLU          
SEQRES  15 U  471  LYS VAL LEU ALA GLY ASP VAL ILE SER ILE ASP LYS ALA          
SEQRES  16 U  471  SER GLY LYS ILE THR LYS LEU GLY ARG SER PHE ALA ARG          
SEQRES  17 U  471  SER ARG ASP TYR ASP ALA MET GLY ALA ASP THR ARG PHE          
SEQRES  18 U  471  VAL GLN CYS PRO GLU GLY GLU LEU GLN LYS ARG LYS THR          
SEQRES  19 U  471  VAL VAL HIS THR VAL SER LEU HIS GLU ILE ASP VAL ILE          
SEQRES  20 U  471  ASN SER ARG THR GLN GLY PHE LEU ALA LEU PHE THR GLY          
SEQRES  21 U  471  ASP THR GLY GLU ILE ARG SER GLU VAL ARG ASP GLN ILE          
SEQRES  22 U  471  ASN THR LYS VAL ALA GLU TRP LYS GLU GLU GLY LYS ALA          
SEQRES  23 U  471  GLU ILE VAL PRO GLY VAL LEU PHE ILE ASP GLU VAL HIS          
SEQRES  24 U  471  MET LEU ASP ILE GLU CYS PHE SER PHE ILE ASN ARG ALA          
SEQRES  25 U  471  LEU GLU ASP GLU PHE ALA PRO ILE VAL MET MET ALA THR          
SEQRES  26 U  471  ASN ARG GLY VAL SER LYS THR ARG GLY THR ASN TYR LYS          
SEQRES  27 U  471  SER PRO HIS GLY LEU PRO LEU ASP LEU LEU ASP ARG SER          
SEQRES  28 U  471  ILE ILE ILE THR THR LYS SER TYR ASN GLU GLN GLU ILE          
SEQRES  29 U  471  LYS THR ILE LEU SER ILE ARG ALA GLN GLU GLU GLU VAL          
SEQRES  30 U  471  GLU LEU SER SER ASP ALA LEU ASP LEU LEU THR LYS THR          
SEQRES  31 U  471  GLY VAL GLU THR SER LEU ARG TYR SER SER ASN LEU ILE          
SEQRES  32 U  471  SER VAL ALA GLN GLN ILE ALA MET LYS ARG LYS ASN ASN          
SEQRES  33 U  471  THR VAL GLU VAL GLU ASP VAL LYS ARG ALA TYR LEU LEU          
SEQRES  34 U  471  PHE LEU ASP SER ALA ARG SER VAL LYS TYR VAL GLN GLU          
SEQRES  35 U  471  ASN GLU SER GLN TYR ILE ASP ASP GLN GLY ASN VAL GLN          
SEQRES  36 U  471  ILE SER ILE ALA LYS SER ALA ASP PRO ASP ALA MET ASP          
SEQRES  37 U  471  THR THR GLU                                                  
SEQRES   1 V  463  MET VAL ALA ILE SER GLU VAL LYS GLU ASN PRO GLY VAL          
SEQRES   2 V  463  ASN SER SER ASN SER GLY ALA VAL THR ARG THR ALA ALA          
SEQRES   3 V  463  HIS THR HIS ILE LYS GLY LEU GLY LEU ASP GLU SER GLY          
SEQRES   4 V  463  VAL ALA LYS ARG VAL GLU GLY GLY PHE VAL GLY GLN ILE          
SEQRES   5 V  463  GLU ALA ARG GLU ALA CYS GLY VAL ILE VAL ASP LEU ILE          
SEQRES   6 V  463  LYS ALA LYS LYS MET SER GLY ARG ALA ILE LEU LEU ALA          
SEQRES   7 V  463  GLY GLY PRO SER THR GLY LYS THR ALA LEU ALA LEU ALA          
SEQRES   8 V  463  ILE SER GLN GLU LEU GLY PRO LYS VAL PRO PHE CYS PRO          
SEQRES   9 V  463  LEU VAL GLY SER GLU LEU TYR SER VAL GLU VAL LYS LYS          
SEQRES  10 V  463  THR GLU THR LEU MET GLU ASN PHE ARG ARG ALA ILE GLY          
SEQRES  11 V  463  LEU ARG ILE LYS GLU THR LYS GLU VAL TYR GLU GLY GLU          
SEQRES  12 V  463  VAL THR GLU LEU THR PRO GLU ASP ALA GLU ASN PRO LEU          
SEQRES  13 V  463  GLY GLY TYR GLY LYS THR ILE SER HIS VAL ILE VAL GLY          
SEQRES  14 V  463  LEU LYS SER ALA LYS GLY THR LYS THR LEU ARG LEU ASP          
SEQRES  15 V  463  PRO THR ILE TYR GLU SER ILE GLN ARG GLU LYS VAL SER          
SEQRES  16 V  463  ILE GLY ASP VAL ILE TYR ILE GLU ALA ASN THR GLY ALA          
SEQRES  17 V  463  VAL LYS ARG VAL GLY ARG SER ASP ALA TYR ALA THR GLU          
SEQRES  18 V  463  PHE ASP LEU GLU THR GLU GLU TYR VAL PRO LEU PRO LYS          
SEQRES  19 V  463  GLY GLU VAL HIS LYS LYS LYS GLU ILE VAL GLN ASP VAL          
SEQRES  20 V  463  THR LEU HIS ASP LEU ASP VAL ALA ASN ALA ARG PRO GLN          
SEQRES  21 V  463  GLY GLY GLN ASP VAL ILE SER MET MET GLY GLN LEU LEU          
SEQRES  22 V  463  LYS PRO LYS LYS THR GLU ILE THR GLU LYS LEU ARG GLN          
SEQRES  23 V  463  GLU VAL ASN LYS VAL VAL ALA LYS TYR ILE ASP GLN GLY          
SEQRES  24 V  463  VAL ALA GLU LEU ILE PRO GLY VAL LEU PHE ILE ASP GLU          
SEQRES  25 V  463  VAL ASN MET LEU ASP ILE GLU ILE PHE THR TYR LEU ASN          
SEQRES  26 V  463  LYS ALA LEU GLU SER ASN ILE ALA PRO VAL VAL VAL LEU          
SEQRES  27 V  463  ALA SER ASN ARG GLY MET THR THR VAL ARG GLY THR GLU          
SEQRES  28 V  463  ASP VAL ILE SER PRO HIS GLY VAL PRO PRO ASP LEU ILE          
SEQRES  29 V  463  ASP ARG LEU LEU ILE VAL ARG THR LEU PRO TYR ASP LYS          
SEQRES  30 V  463  ASP GLU ILE ARG THR ILE ILE GLU ARG ARG ALA THR VAL          
SEQRES  31 V  463  GLU ARG LEU GLN VAL GLU SER SER ALA LEU ASP LEU LEU          
SEQRES  32 V  463  ALA THR MET GLY THR GLU THR SER LEU ARG TYR ALA LEU          
SEQRES  33 V  463  GLN LEU LEU ALA PRO CYS GLY ILE LEU ALA GLN THR SER          
SEQRES  34 V  463  ASN ARG LYS GLU ILE VAL VAL ASN ASP VAL ASN GLU ALA          
SEQRES  35 V  463  LYS LEU LEU PHE LEU ASP ALA LYS ARG SER THR LYS ILE          
SEQRES  36 V  463  LEU GLU THR SER ALA ASN TYR LEU                              
SEQRES   1 W  471  MET SER ILE GLN THR SER ASP PRO ASN GLU THR SER ASP          
SEQRES   2 W  471  LEU LYS SER LEU SER LEU ILE ALA ALA HIS SER HIS ILE          
SEQRES   3 W  471  THR GLY LEU GLY LEU ASP GLU ASN LEU GLN PRO ARG PRO          
SEQRES   4 W  471  THR SER GLU GLY MET VAL GLY GLN LEU GLN ALA ARG ARG          
SEQRES   5 W  471  ALA ALA GLY VAL ILE LEU LYS MET VAL GLN ASN GLY THR          
SEQRES   6 W  471  ILE ALA GLY ARG ALA VAL LEU VAL ALA GLY PRO PRO SER          
SEQRES   7 W  471  THR GLY LYS THR ALA LEU ALA MET GLY VAL SER GLN SER          
SEQRES   8 W  471  LEU GLY LYS ASP VAL PRO PHE THR ALA ILE ALA GLY SER          
SEQRES   9 W  471  GLU ILE PHE SER LEU GLU LEU SER LYS THR GLU ALA LEU          
SEQRES  10 W  471  THR GLN ALA PHE ARG LYS SER ILE GLY ILE LYS ILE LYS          
SEQRES  11 W  471  GLU GLU THR GLU LEU ILE GLU GLY GLU VAL VAL GLU ILE          
SEQRES  12 W  471  GLN ILE ASP ARG SER ILE THR GLY GLY HIS LYS GLN GLY          
SEQRES  13 W  471  LYS LEU THR ILE LYS THR THR ASP MET GLU THR ILE TYR          
SEQRES  14 W  471  GLU LEU GLY ASN LYS MET ILE ASP GLY LEU THR LYS GLU          
SEQRES  15 W  471  LYS VAL LEU ALA GLY ASP VAL ILE SER ILE ASP LYS ALA          
SEQRES  16 W  471  SER GLY LYS ILE THR LYS LEU GLY ARG SER PHE ALA ARG          
SEQRES  17 W  471  SER ARG ASP TYR ASP ALA MET GLY ALA ASP THR ARG PHE          
SEQRES  18 W  471  VAL GLN CYS PRO GLU GLY GLU LEU GLN LYS ARG LYS THR          
SEQRES  19 W  471  VAL VAL HIS THR VAL SER LEU HIS GLU ILE ASP VAL ILE          
SEQRES  20 W  471  ASN SER ARG THR GLN GLY PHE LEU ALA LEU PHE THR GLY          
SEQRES  21 W  471  ASP THR GLY GLU ILE ARG SER GLU VAL ARG ASP GLN ILE          
SEQRES  22 W  471  ASN THR LYS VAL ALA GLU TRP LYS GLU GLU GLY LYS ALA          
SEQRES  23 W  471  GLU ILE VAL PRO GLY VAL LEU PHE ILE ASP GLU VAL HIS          
SEQRES  24 W  471  MET LEU ASP ILE GLU CYS PHE SER PHE ILE ASN ARG ALA          
SEQRES  25 W  471  LEU GLU ASP GLU PHE ALA PRO ILE VAL MET MET ALA THR          
SEQRES  26 W  471  ASN ARG GLY VAL SER LYS THR ARG GLY THR ASN TYR LYS          
SEQRES  27 W  471  SER PRO HIS GLY LEU PRO LEU ASP LEU LEU ASP ARG SER          
SEQRES  28 W  471  ILE ILE ILE THR THR LYS SER TYR ASN GLU GLN GLU ILE          
SEQRES  29 W  471  LYS THR ILE LEU SER ILE ARG ALA GLN GLU GLU GLU VAL          
SEQRES  30 W  471  GLU LEU SER SER ASP ALA LEU ASP LEU LEU THR LYS THR          
SEQRES  31 W  471  GLY VAL GLU THR SER LEU ARG TYR SER SER ASN LEU ILE          
SEQRES  32 W  471  SER VAL ALA GLN GLN ILE ALA MET LYS ARG LYS ASN ASN          
SEQRES  33 W  471  THR VAL GLU VAL GLU ASP VAL LYS ARG ALA TYR LEU LEU          
SEQRES  34 W  471  PHE LEU ASP SER ALA ARG SER VAL LYS TYR VAL GLN GLU          
SEQRES  35 W  471  ASN GLU SER GLN TYR ILE ASP ASP GLN GLY ASN VAL GLN          
SEQRES  36 W  471  ILE SER ILE ALA LYS SER ALA ASP PRO ASP ALA MET ASP          
SEQRES  37 W  471  THR THR GLU                                                  
SEQRES   1 X  463  MET VAL ALA ILE SER GLU VAL LYS GLU ASN PRO GLY VAL          
SEQRES   2 X  463  ASN SER SER ASN SER GLY ALA VAL THR ARG THR ALA ALA          
SEQRES   3 X  463  HIS THR HIS ILE LYS GLY LEU GLY LEU ASP GLU SER GLY          
SEQRES   4 X  463  VAL ALA LYS ARG VAL GLU GLY GLY PHE VAL GLY GLN ILE          
SEQRES   5 X  463  GLU ALA ARG GLU ALA CYS GLY VAL ILE VAL ASP LEU ILE          
SEQRES   6 X  463  LYS ALA LYS LYS MET SER GLY ARG ALA ILE LEU LEU ALA          
SEQRES   7 X  463  GLY GLY PRO SER THR GLY LYS THR ALA LEU ALA LEU ALA          
SEQRES   8 X  463  ILE SER GLN GLU LEU GLY PRO LYS VAL PRO PHE CYS PRO          
SEQRES   9 X  463  LEU VAL GLY SER GLU LEU TYR SER VAL GLU VAL LYS LYS          
SEQRES  10 X  463  THR GLU THR LEU MET GLU ASN PHE ARG ARG ALA ILE GLY          
SEQRES  11 X  463  LEU ARG ILE LYS GLU THR LYS GLU VAL TYR GLU GLY GLU          
SEQRES  12 X  463  VAL THR GLU LEU THR PRO GLU ASP ALA GLU ASN PRO LEU          
SEQRES  13 X  463  GLY GLY TYR GLY LYS THR ILE SER HIS VAL ILE VAL GLY          
SEQRES  14 X  463  LEU LYS SER ALA LYS GLY THR LYS THR LEU ARG LEU ASP          
SEQRES  15 X  463  PRO THR ILE TYR GLU SER ILE GLN ARG GLU LYS VAL SER          
SEQRES  16 X  463  ILE GLY ASP VAL ILE TYR ILE GLU ALA ASN THR GLY ALA          
SEQRES  17 X  463  VAL LYS ARG VAL GLY ARG SER ASP ALA TYR ALA THR GLU          
SEQRES  18 X  463  PHE ASP LEU GLU THR GLU GLU TYR VAL PRO LEU PRO LYS          
SEQRES  19 X  463  GLY GLU VAL HIS LYS LYS LYS GLU ILE VAL GLN ASP VAL          
SEQRES  20 X  463  THR LEU HIS ASP LEU ASP VAL ALA ASN ALA ARG PRO GLN          
SEQRES  21 X  463  GLY GLY GLN ASP VAL ILE SER MET MET GLY GLN LEU LEU          
SEQRES  22 X  463  LYS PRO LYS LYS THR GLU ILE THR GLU LYS LEU ARG GLN          
SEQRES  23 X  463  GLU VAL ASN LYS VAL VAL ALA LYS TYR ILE ASP GLN GLY          
SEQRES  24 X  463  VAL ALA GLU LEU ILE PRO GLY VAL LEU PHE ILE ASP GLU          
SEQRES  25 X  463  VAL ASN MET LEU ASP ILE GLU ILE PHE THR TYR LEU ASN          
SEQRES  26 X  463  LYS ALA LEU GLU SER ASN ILE ALA PRO VAL VAL VAL LEU          
SEQRES  27 X  463  ALA SER ASN ARG GLY MET THR THR VAL ARG GLY THR GLU          
SEQRES  28 X  463  ASP VAL ILE SER PRO HIS GLY VAL PRO PRO ASP LEU ILE          
SEQRES  29 X  463  ASP ARG LEU LEU ILE VAL ARG THR LEU PRO TYR ASP LYS          
SEQRES  30 X  463  ASP GLU ILE ARG THR ILE ILE GLU ARG ARG ALA THR VAL          
SEQRES  31 X  463  GLU ARG LEU GLN VAL GLU SER SER ALA LEU ASP LEU LEU          
SEQRES  32 X  463  ALA THR MET GLY THR GLU THR SER LEU ARG TYR ALA LEU          
SEQRES  33 X  463  GLN LEU LEU ALA PRO CYS GLY ILE LEU ALA GLN THR SER          
SEQRES  34 X  463  ASN ARG LYS GLU ILE VAL VAL ASN ASP VAL ASN GLU ALA          
SEQRES  35 X  463  LYS LEU LEU PHE LEU ASP ALA LYS ARG SER THR LYS ILE          
SEQRES  36 X  463  LEU GLU THR SER ALA ASN TYR LEU                              
SEQRES   1 Y  471  MET SER ILE GLN THR SER ASP PRO ASN GLU THR SER ASP          
SEQRES   2 Y  471  LEU LYS SER LEU SER LEU ILE ALA ALA HIS SER HIS ILE          
SEQRES   3 Y  471  THR GLY LEU GLY LEU ASP GLU ASN LEU GLN PRO ARG PRO          
SEQRES   4 Y  471  THR SER GLU GLY MET VAL GLY GLN LEU GLN ALA ARG ARG          
SEQRES   5 Y  471  ALA ALA GLY VAL ILE LEU LYS MET VAL GLN ASN GLY THR          
SEQRES   6 Y  471  ILE ALA GLY ARG ALA VAL LEU VAL ALA GLY PRO PRO SER          
SEQRES   7 Y  471  THR GLY LYS THR ALA LEU ALA MET GLY VAL SER GLN SER          
SEQRES   8 Y  471  LEU GLY LYS ASP VAL PRO PHE THR ALA ILE ALA GLY SER          
SEQRES   9 Y  471  GLU ILE PHE SER LEU GLU LEU SER LYS THR GLU ALA LEU          
SEQRES  10 Y  471  THR GLN ALA PHE ARG LYS SER ILE GLY ILE LYS ILE LYS          
SEQRES  11 Y  471  GLU GLU THR GLU LEU ILE GLU GLY GLU VAL VAL GLU ILE          
SEQRES  12 Y  471  GLN ILE ASP ARG SER ILE THR GLY GLY HIS LYS GLN GLY          
SEQRES  13 Y  471  LYS LEU THR ILE LYS THR THR ASP MET GLU THR ILE TYR          
SEQRES  14 Y  471  GLU LEU GLY ASN LYS MET ILE ASP GLY LEU THR LYS GLU          
SEQRES  15 Y  471  LYS VAL LEU ALA GLY ASP VAL ILE SER ILE ASP LYS ALA          
SEQRES  16 Y  471  SER GLY LYS ILE THR LYS LEU GLY ARG SER PHE ALA ARG          
SEQRES  17 Y  471  SER ARG ASP TYR ASP ALA MET GLY ALA ASP THR ARG PHE          
SEQRES  18 Y  471  VAL GLN CYS PRO GLU GLY GLU LEU GLN LYS ARG LYS THR          
SEQRES  19 Y  471  VAL VAL HIS THR VAL SER LEU HIS GLU ILE ASP VAL ILE          
SEQRES  20 Y  471  ASN SER ARG THR GLN GLY PHE LEU ALA LEU PHE THR GLY          
SEQRES  21 Y  471  ASP THR GLY GLU ILE ARG SER GLU VAL ARG ASP GLN ILE          
SEQRES  22 Y  471  ASN THR LYS VAL ALA GLU TRP LYS GLU GLU GLY LYS ALA          
SEQRES  23 Y  471  GLU ILE VAL PRO GLY VAL LEU PHE ILE ASP GLU VAL HIS          
SEQRES  24 Y  471  MET LEU ASP ILE GLU CYS PHE SER PHE ILE ASN ARG ALA          
SEQRES  25 Y  471  LEU GLU ASP GLU PHE ALA PRO ILE VAL MET MET ALA THR          
SEQRES  26 Y  471  ASN ARG GLY VAL SER LYS THR ARG GLY THR ASN TYR LYS          
SEQRES  27 Y  471  SER PRO HIS GLY LEU PRO LEU ASP LEU LEU ASP ARG SER          
SEQRES  28 Y  471  ILE ILE ILE THR THR LYS SER TYR ASN GLU GLN GLU ILE          
SEQRES  29 Y  471  LYS THR ILE LEU SER ILE ARG ALA GLN GLU GLU GLU VAL          
SEQRES  30 Y  471  GLU LEU SER SER ASP ALA LEU ASP LEU LEU THR LYS THR          
SEQRES  31 Y  471  GLY VAL GLU THR SER LEU ARG TYR SER SER ASN LEU ILE          
SEQRES  32 Y  471  SER VAL ALA GLN GLN ILE ALA MET LYS ARG LYS ASN ASN          
SEQRES  33 Y  471  THR VAL GLU VAL GLU ASP VAL LYS ARG ALA TYR LEU LEU          
SEQRES  34 Y  471  PHE LEU ASP SER ALA ARG SER VAL LYS TYR VAL GLN GLU          
SEQRES  35 Y  471  ASN GLU SER GLN TYR ILE ASP ASP GLN GLY ASN VAL GLN          
SEQRES  36 Y  471  ILE SER ILE ALA LYS SER ALA ASP PRO ASP ALA MET ASP          
SEQRES  37 Y  471  THR THR GLU                                                  
HET    ADP  M1601      27                                                       
HET    BEF  M1602       4                                                       
HET     MG  M1603       1                                                       
HET    ADP  R 501      27                                                       
HET    BEF  R 502       4                                                       
HET     MG  R 503       1                                                       
HET     ZN  S 501       1                                                       
HET     ZN  S 502       1                                                       
HET    ADP  T 501      27                                                       
HET     MG  U 501       1                                                       
HET    ADP  U 502      27                                                       
HET     MG  U 503       1                                                       
HET    ADP  V 501      27                                                       
HET     MG  V 502       1                                                       
HET    ADP  W 501      27                                                       
HET     MG  W 502       1                                                       
HET    ADP  X 501      27                                                       
HET     MG  Y 501       1                                                       
HET    ADP  Y 502      27                                                       
HET     MG  Y 503       1                                                       
HETNAM     ADP ADENOSINE-5'-DIPHOSPHATE                                         
HETNAM     BEF BERYLLIUM TRIFLUORIDE ION                                        
HETNAM      MG MAGNESIUM ION                                                    
HETNAM      ZN ZINC ION                                                         
FORMUL  21  ADP    8(C10 H15 N5 O10 P2)                                         
FORMUL  22  BEF    2(BE F3 1-)                                                  
FORMUL  23   MG    8(MG 2+)                                                     
FORMUL  27   ZN    2(ZN 2+)                                                     
HELIX    1 AA1 UNK Z  101  UNK Z  129  1                                  29    
HELIX    2 AA2 UNK Z  136  UNK Z  142  1                                   7    
HELIX    3 AA3 THR A   45  GLN A   55  1                                  11    
HELIX    4 AA4 ARG A   63  ALA A   75  1                                  13    
HELIX    5 AA5 ILE A   89  ALA A  114  1                                  26    
HELIX    6 AA6 GLN A  120  LEU A  130  1                                  11    
HELIX    7 AA7 THR B   45  GLN B   55  1                                  11    
HELIX    8 AA8 ARG B   63  ALA B   75  1                                  13    
HELIX    9 AA9 ILE B   89  ALA B  114  1                                  26    
HELIX   10 AB1 GLN B  120  LEU B  130  1                                  11    
HELIX   11 AB2 ASN C   25  ILE C   29  5                                   5    
HELIX   12 AB3 THR C   30  GLY C   41  1                                  12    
HELIX   13 AB4 LEU C   49  ALA C   76  1                                  28    
HELIX   14 AB5 THR C   82  LEU C   90  1                                   9    
HELIX   15 AB6 ASN D   25  ILE D   29  5                                   5    
HELIX   16 AB7 THR D   30  GLY D   41  1                                  12    
HELIX   17 AB8 LEU D   49  ALA D   76  1                                  28    
HELIX   18 AB9 THR D   82  LEU D   90  1                                   9    
HELIX   19 AC1 SER E   17  ALA E   22  1                                   6    
HELIX   20 AC2 PRO E   27  ARG E   37  1                                  11    
HELIX   21 AC3 GLY E   47  ASN E   74  1                                  28    
HELIX   22 AC4 ILE E   80  ASN E   90  1                                  11    
HELIX   23 AC5 ASP E   91  LEU E   98  1                                   8    
HELIX   24 AC6 ARG F   18  ALA F   22  1                                   5    
HELIX   25 AC7 PRO F   27  ARG F   37  1                                  11    
HELIX   26 AC8 GLY F   47  ASN F   74  1                                  28    
HELIX   27 AC9 ILE F   80  ASN F   90  1                                  11    
HELIX   28 AD1 ASP F   91  LEU F   98  1                                   8    
HELIX   29 AD2 TYR G   40  HIS G   52  1                                  13    
HELIX   30 AD3 SER G   58  ASN G   87  1                                  30    
HELIX   31 AD4 SER G   93  LEU G  105  1                                  13    
HELIX   32 AD5 PRO G  106  SER G  126  1                                  21    
HELIX   33 AD6 TYR H   40  HIS H   52  1                                  13    
HELIX   34 AD7 SER H   58  ASN H   87  1                                  30    
HELIX   35 AD8 SER H   93  LEU H  105  1                                  13    
HELIX   36 AD9 PRO H  106  SER H  125  1                                  20    
HELIX   37 AE1 ARG M  697  ASN M  712  1                                  16    
HELIX   38 AE2 GLY M  726  LYS M  742  1                                  17    
HELIX   39 AE3 VAL M  756  PHE M  767  1                                  12    
HELIX   40 AE4 GLN M  781  ARG M  787  1                                   7    
HELIX   41 AE5 GLN M  804  ASP M  809  1                                   6    
HELIX   42 AE6 ASP M  809  LYS M  814  1                                   6    
HELIX   43 AE7 SER M  834  LEU M  840  1                                   7    
HELIX   44 AE8 ASN M  859  MET M  871  1                                  13    
HELIX   45 AE9 THR M  914  LEU M  925  1                                  12    
HELIX   46 AF1 SER M  954  LYS M  971  1                                  18    
HELIX   47 AF2 ALA M  972  ALA M  975  5                                   4    
HELIX   48 AF3 PHE M  979  ASN M  994  1                                  16    
HELIX   49 AF4 CYS M 1013  TYR M 1018  1                                   6    
HELIX   50 AF5 TYR M 1018  PHE M 1029  1                                  12    
HELIX   51 AF6 VAL M 1046  ASN M 1050  5                                   5    
HELIX   52 AF7 THR M 1055  LYS M 1064  1                                  10    
HELIX   53 AF8 ASN M 1070  PHE M 1094  1                                  25    
HELIX   54 AF9 PHE M 1104  ARG M 1133  1                                  30    
HELIX   55 AG1 ILE M 1141  ASP M 1147  1                                   7    
HELIX   56 AG2 ILE M 1158  ILE M 1163  1                                   6    
HELIX   57 AG3 PRO M 1165  ASN M 1173  1                                   9    
HELIX   58 AG4 ASN M 1173  ALA M 1181  1                                   9    
HELIX   59 AG5 MET M 1192  GLY M 1198  1                                   7    
HELIX   60 AG6 ASN M 1208  VAL M 1220  1                                  13    
HELIX   61 AG7 LEU M 1224  ILE M 1233  1                                  10    
HELIX   62 AG8 SER M 1239  ASP M 1244  1                                   6    
HELIX   63 AG9 LYS M 1250  ASN M 1261  1                                  12    
HELIX   64 AH1 THR M 1272  GLY M 1286  1                                  15    
HELIX   65 AH2 ILE M 1298  THR M 1310  1                                  13    
HELIX   66 AH3 ALA M 1346  ARG M 1354  1                                   9    
HELIX   67 AH4 THR M 1374  LYS M 1386  1                                  13    
HELIX   68 AH5 LEU R   68  PHE R   81  1                                  14    
HELIX   69 AH6 LEU R  108  GLU R  122  1                                  15    
HELIX   70 AH7 PRO R  132  VAL R  137  1                                   6    
HELIX   71 AH8 PRO R  138  TYR R  143  5                                   6    
HELIX   72 AH9 GLY R  219  HIS R  235  1                                  17    
HELIX   73 AI1 THR R  242  CYS R  252  1                                  11    
HELIX   74 AI2 SER R  259  THR R  266  1                                   8    
HELIX   75 AI3 ASP R  308  ILE R  313  1                                   6    
HELIX   76 AI4 PRO R  314  PHE R  317  5                                   4    
HELIX   77 AI5 GLY R  329  MET R  340  1                                  12    
HELIX   78 AI6 VAL R  345  VAL R  350  1                                   6    
HELIX   79 AI7 GLY R  358  LEU R  362  5                                   5    
HELIX   80 AI8 ASN R  364  ARG R  375  1                                  12    
HELIX   81 AI9 ASP R  391  PHE R  403  1                                  13    
HELIX   82 AJ1 ASP R  407  ARG R  413  1                                   7    
HELIX   83 AJ2 ARG R  416  HIS R  422  1                                   7    
HELIX   84 AJ3 GLY R  423  HIS R  430  1                                   8    
HELIX   85 AJ4 GLY R  433  ILE R  438  1                                   6    
HELIX   86 AJ5 SER S   52  TYR S   61  1                                  10    
HELIX   87 AJ6 THR S   91  THR S  107  1                                  17    
HELIX   88 AJ7 ASN S  115  GLY S  125  1                                  11    
HELIX   89 AJ8 PRO S  127  THR S  135  1                                   9    
HELIX   90 AJ9 LYS S  168  LYS S  180  1                                  13    
HELIX   91 AK1 THR S  192  SER S  203  1                                  12    
HELIX   92 AK2 ASN S  207  SER S  214  1                                   8    
HELIX   93 AK3 ASN S  218  TYR S  226  1                                   9    
HELIX   94 AK4 SER S  265  LEU S  271  1                                   7    
HELIX   95 AK5 GLN T   51  LYS T   66  1                                  16    
HELIX   96 AK6 LYS T   85  GLY T   97  1                                  13    
HELIX   97 AK7 SER T  108  TYR T  111  5                                   4    
HELIX   98 AK8 LYS T  116  ILE T  129  1                                  14    
HELIX   99 AK9 ASP T  182  GLU T  192  1                                  11    
HELIX  100 AL1 ALA T  217  ALA T  219  5                                   3    
HELIX  101 AL2 LEU T  249  ARG T  258  1                                  10    
HELIX  102 AL3 ASP T  264  LYS T  274  1                                  11    
HELIX  103 AL4 THR T  281  GLN T  298  1                                  18    
HELIX  104 AL5 VAL T  313  LEU T  316  5                                   4    
HELIX  105 AL6 ASP T  317  GLU T  329  1                                  13    
HELIX  106 AL7 PRO T  356  VAL T  359  5                                   4    
HELIX  107 AL8 PRO T  360  ARG T  366  1                                   7    
HELIX  108 AL9 ASP T  376  GLU T  391  1                                  16    
HELIX  109 AM1 GLU T  396  THR T  408  1                                  13    
HELIX  110 AM2 SER T  411  LEU T  418  1                                   8    
HELIX  111 AM3 LEU T  418  SER T  429  1                                  12    
HELIX  112 AM4 VAL T  435  PHE T  446  1                                  12    
HELIX  113 AM5 ASP T  448  THR T  458  1                                  11    
HELIX  114 AM6 GLN U   47  GLY U   64  1                                  18    
HELIX  115 AM7 GLY U   80  GLY U   93  1                                  14    
HELIX  116 AM8 SER U  112  SER U  124  1                                  13    
HELIX  117 AM9 GLY U  172  GLU U  182  1                                  11    
HELIX  118 AN1 LEU U  241  ASN U  248  1                                   8    
HELIX  119 AN2 ARG U  250  GLY U  253  5                                   4    
HELIX  120 AN3 PHE U  254  GLY U  260  1                                   7    
HELIX  121 AN4 ARG U  266  GLU U  283  1                                  18    
HELIX  122 AN5 ASP U  302  LEU U  313  1                                  12    
HELIX  123 AN6 SER U  339  LEU U  343  5                                   5    
HELIX  124 AN7 PRO U  344  ARG U  350  1                                   7    
HELIX  125 AN8 ASN U  360  GLU U  375  1                                  16    
HELIX  126 AN9 SER U  380  THR U  394  1                                  15    
HELIX  127 AO1 SER U  395  ARG U  413  1                                  19    
HELIX  128 AO2 GLU U  419  PHE U  430  1                                  12    
HELIX  129 AO3 ASP U  432  ASN U  443  1                                  12    
HELIX  130 AO4 GLN V   51  LYS V   66  1                                  16    
HELIX  131 AO5 LYS V   85  GLY V   97  1                                  13    
HELIX  132 AO6 SER V  108  TYR V  111  5                                   4    
HELIX  133 AO7 LYS V  116  ILE V  129  1                                  14    
HELIX  134 AO8 ASP V  182  GLU V  192  1                                  11    
HELIX  135 AO9 ALA V  217  ALA V  219  5                                   3    
HELIX  136 AP1 LEU V  249  ARG V  258  1                                  10    
HELIX  137 AP2 ASP V  264  LYS V  274  1                                  11    
HELIX  138 AP3 THR V  281  GLN V  298  1                                  18    
HELIX  139 AP4 VAL V  313  LEU V  316  5                                   4    
HELIX  140 AP5 ASP V  317  GLU V  329  1                                  13    
HELIX  141 AP6 PRO V  356  VAL V  359  5                                   4    
HELIX  142 AP7 PRO V  360  ARG V  366  1                                   7    
HELIX  143 AP8 ASP V  376  GLU V  391  1                                  16    
HELIX  144 AP9 GLU V  396  THR V  408  1                                  13    
HELIX  145 AQ1 SER V  411  LEU V  418  1                                   8    
HELIX  146 AQ2 LEU V  418  SER V  429  1                                  12    
HELIX  147 AQ3 VAL V  435  PHE V  446  1                                  12    
HELIX  148 AQ4 ASP V  448  THR V  458  1                                  11    
HELIX  149 AQ5 GLN W   47  GLY W   64  1                                  18    
HELIX  150 AQ6 GLY W   80  GLY W   93  1                                  14    
HELIX  151 AQ7 SER W  112  SER W  124  1                                  13    
HELIX  152 AQ8 GLY W  172  GLU W  182  1                                  11    
HELIX  153 AQ9 LEU W  241  ASN W  248  1                                   8    
HELIX  154 AR1 ARG W  250  GLY W  253  5                                   4    
HELIX  155 AR2 PHE W  254  GLY W  260  1                                   7    
HELIX  156 AR3 ARG W  266  GLU W  283  1                                  18    
HELIX  157 AR4 ASP W  302  LEU W  313  1                                  12    
HELIX  158 AR5 SER W  339  LEU W  343  5                                   5    
HELIX  159 AR6 PRO W  344  ARG W  350  1                                   7    
HELIX  160 AR7 ASN W  360  GLU W  375  1                                  16    
HELIX  161 AR8 SER W  380  THR W  394  1                                  15    
HELIX  162 AR9 SER W  395  ARG W  413  1                                  19    
HELIX  163 AS1 GLU W  419  PHE W  430  1                                  12    
HELIX  164 AS2 ASP W  432  ASN W  443  1                                  12    
HELIX  165 AS3 GLN X   51  LYS X   66  1                                  16    
HELIX  166 AS4 LYS X   85  GLY X   97  1                                  13    
HELIX  167 AS5 SER X  108  TYR X  111  5                                   4    
HELIX  168 AS6 LYS X  116  ILE X  129  1                                  14    
HELIX  169 AS7 ASP X  182  GLU X  192  1                                  11    
HELIX  170 AS8 ALA X  217  ALA X  219  5                                   3    
HELIX  171 AS9 LEU X  249  ARG X  258  1                                  10    
HELIX  172 AT1 ASP X  264  LYS X  274  1                                  11    
HELIX  173 AT2 THR X  281  GLN X  298  1                                  18    
HELIX  174 AT3 VAL X  313  LEU X  316  5                                   4    
HELIX  175 AT4 ASP X  317  GLU X  329  1                                  13    
HELIX  176 AT5 PRO X  356  VAL X  359  5                                   4    
HELIX  177 AT6 PRO X  360  ARG X  366  1                                   7    
HELIX  178 AT7 ASP X  376  GLU X  391  1                                  16    
HELIX  179 AT8 GLU X  396  THR X  408  1                                  13    
HELIX  180 AT9 SER X  411  LEU X  418  1                                   8    
HELIX  181 AU1 LEU X  418  SER X  429  1                                  12    
HELIX  182 AU2 VAL X  435  PHE X  446  1                                  12    
HELIX  183 AU3 ASP X  448  THR X  458  1                                  11    
HELIX  184 AU4 GLN Y   47  GLY Y   64  1                                  18    
HELIX  185 AU5 GLY Y   80  GLY Y   93  1                                  14    
HELIX  186 AU6 SER Y  112  SER Y  124  1                                  13    
HELIX  187 AU7 GLY Y  172  LYS Y  181  1                                  10    
HELIX  188 AU8 LEU Y  241  ASN Y  248  1                                   8    
HELIX  189 AU9 ARG Y  250  GLY Y  253  5                                   4    
HELIX  190 AV1 PHE Y  254  GLY Y  260  1                                   7    
HELIX  191 AV2 ARG Y  266  GLU Y  283  1                                  18    
HELIX  192 AV3 ASP Y  302  LEU Y  313  1                                  12    
HELIX  193 AV4 SER Y  339  LEU Y  343  5                                   5    
HELIX  194 AV5 PRO Y  344  ARG Y  350  1                                   7    
HELIX  195 AV6 ASN Y  360  GLU Y  375  1                                  16    
HELIX  196 AV7 SER Y  380  THR Y  394  1                                  15    
HELIX  197 AV8 SER Y  395  ARG Y  413  1                                  19    
HELIX  198 AV9 GLU Y  419  PHE Y  430  1                                  12    
HELIX  199 AW1 ASP Y  432  ASN Y  443  1                                  12    
SHEET    1 AA1 2 UNK Z 169  UNK Z 171  0                                        
SHEET    2 AA1 2 UNK Z 176  UNK Z 178 -1  O  UNK Z 177   N  UNK Z 170           
SHEET    1 AA2 2 ARG A  83  PHE A  84  0                                        
SHEET    2 AA2 2 THR D  80  VAL D  81  1  O  VAL D  81   N  ARG A  83           
SHEET    1 AA3 2 THR A 118  ILE A 119  0                                        
SHEET    2 AA3 2 ARG D  45  ILE D  46  1  O  ARG D  45   N  ILE A 119           
SHEET    1 AA4 2 ARG B  83  PHE B  84  0                                        
SHEET    2 AA4 2 THR C  80  VAL C  81  1  O  VAL C  81   N  ARG B  83           
SHEET    1 AA5 2 THR B 118  ILE B 119  0                                        
SHEET    2 AA5 2 ARG C  45  ILE C  46  1  O  ARG C  45   N  ILE B 119           
SHEET    1 AA6 2 ARG E  43  ILE E  44  0                                        
SHEET    2 AA6 2 THR G  91  ILE G  92  1  O  ILE G  92   N  ARG E  43           
SHEET    1 AA7 2 ARG E  78  ILE E  79  0                                        
SHEET    2 AA7 2 GLY G  56  ILE G  57  1  O  GLY G  56   N  ILE E  79           
SHEET    1 AA8 2 ARG F  43  ILE F  44  0                                        
SHEET    2 AA8 2 THR H  91  ILE H  92  1  O  ILE H  92   N  ARG F  43           
SHEET    1 AA9 2 ARG F  78  ILE F  79  0                                        
SHEET    2 AA9 2 GLY H  56  ILE H  57  1  O  GLY H  56   N  ILE F  79           
SHEET    1 AB1 6 ILE M 718  LEU M 719  0                                        
SHEET    2 AB1 6 ARG M 847  LEU M 851  1  O  LEU M 850   N  LEU M 719           
SHEET    3 AB1 6 TYR M 820  ASP M 824  1  N  LEU M 823   O  LEU M 851           
SHEET    4 AB1 6 HIS M 748  VAL M 752  1  N  VAL M 751   O  ASP M 824           
SHEET    5 AB1 6 VAL M 798  SER M 802  1  O  CYS M 799   N  ILE M 750           
SHEET    6 AB1 6 VAL M 773  LEU M 774  1  N  LEU M 774   O  VAL M 798           
SHEET    1 AB2 6 LYS M 944  GLU M 946  0                                        
SHEET    2 AB2 6 VAL M1364  ILE M1366  1  O  ILE M1366   N  TYR M 945           
SHEET    3 AB2 6 THR M1335  PHE M1338  1  N  VAL M1336   O  HIS M1365           
SHEET    4 AB2 6 ALA M1265  THR M1269  1  N  LEU M1266   O  THR M1335           
SHEET    5 AB2 6 VAL M1316  SER M1320  1  O  LEU M1319   N  ILE M1267           
SHEET    6 AB2 6 TYR M1289  ARG M1291  1  N  MET M1290   O  ILE M1318           
SHEET    1 AB3 2 VAL M 949  CYS M 951  0                                        
SHEET    2 AB3 2 PHE M1369  SER M1371  1  O  VAL M1370   N  VAL M 949           
SHEET    1 AB4 6 PHE R  26  LEU R  29  0                                        
SHEET    2 AB4 6 GLU R  14  PRO R  19 -1  N  PHE R  17   O  PHE R  26           
SHEET    3 AB4 6 ILE R   6  ASP R   9 -1  N  ASP R   9   O  LYS R  16           
SHEET    4 AB4 6 HIS R  98  ALA R 101  1  O  VAL R 100   N  ILE R   6           
SHEET    5 AB4 6 SER R 127  LYS R 130  1  O  PHE R 129   N  LEU R  99           
SHEET    6 AB4 6 VAL R 414  THR R 415 -1  O  VAL R 414   N  LEU R 128           
SHEET    1 AB5 3 SER R  40  TYR R  41  0                                        
SHEET    2 AB5 3 LEU R  32  ASP R  35 -1  N  ALA R  33   O  TYR R  41           
SHEET    3 AB5 3 ILE R  55  ARG R  58 -1  O  THR R  56   N  LYS R  34           
SHEET    1 AB6 6 MET R 147  SER R 151  0                                        
SHEET    2 AB6 6 HIS R 384  PRO R 388 -1  O  VAL R 385   N  ILE R 150           
SHEET    3 AB6 6 ILE R 353  THR R 356  1  N  ILE R 353   O  SER R 386           
SHEET    4 AB6 6 GLN R 188  ASP R 192  1  N  LEU R 189   O  VAL R 354           
SHEET    5 AB6 6 THR R 198  LEU R 204 -1  O  TRP R 199   N  ASP R 192           
SHEET    6 AB6 6 ILE R 207  PRO R 208 -1  O  ILE R 207   N  LEU R 204           
SHEET    1 AB7 6 MET R 147  SER R 151  0                                        
SHEET    2 AB7 6 HIS R 384  PRO R 388 -1  O  VAL R 385   N  ILE R 150           
SHEET    3 AB7 6 ILE R 353  THR R 356  1  N  ILE R 353   O  SER R 386           
SHEET    4 AB7 6 GLN R 188  ASP R 192  1  N  LEU R 189   O  VAL R 354           
SHEET    5 AB7 6 THR R 198  LEU R 204 -1  O  TRP R 199   N  ASP R 192           
SHEET    6 AB7 6 LYS R 214  LEU R 216 -1  O  LEU R 216   N  THR R 198           
SHEET    1 AB8 3 TYR R 286  ARG R 288  0                                        
SHEET    2 AB8 3 LEU R 272  VAL R 275 -1  N  GLU R 273   O  ARG R 288           
SHEET    3 AB8 3 ILE R 303  LEU R 306 -1  O  ILE R 304   N  TYR R 274           
SHEET    1 AB9 7 VAL S   5  GLU S   7  0                                        
SHEET    2 AB9 7 THR V 176  LEU V 181 -1  O  ARG V 180   N  GLU S   6           
SHEET    3 AB9 7 ILE V 167  LYS V 171 -1  N  VAL V 168   O  LEU V 179           
SHEET    4 AB9 7 GLU V 135  THR V 148 -1  N  GLU V 143   O  LYS V 171           
SHEET    5 AB9 7 ASP V 198  GLU V 203 -1  O  ILE V 202   N  TYR V 140           
SHEET    6 AB9 7 VAL V 209  SER V 215 -1  O  GLY V 213   N  VAL V 199           
SHEET    7 AB9 7 TYR V 229  VAL V 230  1  O  VAL V 230   N  ARG V 214           
SHEET    1 AC1 5 VAL S   5  GLU S   7  0                                        
SHEET    2 AC1 5 THR V 176  LEU V 181 -1  O  ARG V 180   N  GLU S   6           
SHEET    3 AC1 5 ILE V 167  LYS V 171 -1  N  VAL V 168   O  LEU V 179           
SHEET    4 AC1 5 GLU V 135  THR V 148 -1  N  GLU V 143   O  LYS V 171           
SHEET    5 AC1 5 HIS V 238  ILE V 243 -1  O  LYS V 239   N  VAL V 139           
SHEET    1 AC2 5 PHE T 102  VAL T 106  0                                        
SHEET    2 AC2 5 VAL T 307  ASP T 311  1  O  VAL T 307   N  CYS T 103           
SHEET    3 AC2 5 VAL T 335  SER T 340  1  O  VAL T 337   N  ILE T 310           
SHEET    4 AC2 5 ALA T  74  ALA T  78  1  N  LEU T  77   O  LEU T 338           
SHEET    5 AC2 5 LEU T 367  ARG T 371  1  O  LEU T 368   N  LEU T  76           
SHEET    1 AC3 3 ASP T 246  THR T 248  0                                        
SHEET    2 AC3 3 GLY T 130  ARG T 132 -1  N  LEU T 131   O  VAL T 247           
SHEET    3 AC3 3 GLU T 302  ILE T 304 -1  O  ILE T 304   N  GLY T 130           
SHEET    1 AC4 6 THR T 176  ARG T 180  0                                        
SHEET    2 AC4 6 ILE T 167  LYS T 171 -1  N  VAL T 168   O  LEU T 179           
SHEET    3 AC4 6 GLU T 135  THR T 148 -1  N  GLU T 143   O  LYS T 171           
SHEET    4 AC4 6 ASP T 198  GLU T 203 -1  O  ILE T 202   N  TYR T 140           
SHEET    5 AC4 6 VAL T 209  SER T 215 -1  O  GLY T 213   N  VAL T 199           
SHEET    6 AC4 6 TYR T 229  VAL T 230  1  O  VAL T 230   N  ARG T 214           
SHEET    1 AC5 4 THR T 176  ARG T 180  0                                        
SHEET    2 AC5 4 ILE T 167  LYS T 171 -1  N  VAL T 168   O  LEU T 179           
SHEET    3 AC5 4 GLU T 135  THR T 148 -1  N  GLU T 143   O  LYS T 171           
SHEET    4 AC5 4 HIS T 238  ILE T 243 -1  O  LYS T 239   N  VAL T 139           
SHEET    1 AC6 2 THR T 345  THR T 346  0                                        
SHEET    2 AC6 2 ILE T 354  SER T 355 -1  O  SER T 355   N  THR T 345           
SHEET    1 AC7 2 THR U  40  SER U  41  0                                        
SHEET    2 AC7 2 MET U  44  VAL U  45 -1  O  MET U  44   N  SER U  41           
SHEET    1 AC8 5 PHE U  98  ALA U 102  0                                        
SHEET    2 AC8 5 VAL U 292  ASP U 296  1  O  PHE U 294   N  THR U  99           
SHEET    3 AC8 5 ILE U 320  ALA U 324  1  O  MET U 322   N  LEU U 293           
SHEET    4 AC8 5 ALA U  70  ALA U  74  1  N  VAL U  71   O  VAL U 321           
SHEET    5 AC8 5 SER U 351  THR U 355  1  O  ILE U 354   N  LEU U  72           
SHEET    1 AC9 4 GLU U 166  LEU U 171  0                                        
SHEET    2 AC9 4 GLY U 156  LYS U 161 -1  N  GLY U 156   O  LEU U 171           
SHEET    3 AC9 4 GLY U 126  GLN U 144 -1  N  GLN U 144   O  LYS U 157           
SHEET    4 AC9 4 GLN U 230  SER U 240 -1  O  LYS U 231   N  LEU U 135           
SHEET    1 AD1 4 ILE U 199  ARG U 204  0                                        
SHEET    2 AD1 4 ASP U 188  ASP U 193 -1  N  VAL U 189   O  GLY U 203           
SHEET    3 AD1 4 GLY U 126  GLN U 144 -1  N  ILE U 136   O  ILE U 192           
SHEET    4 AD1 4 GLU U 287  VAL U 289 -1  O  GLU U 287   N  LYS U 128           
SHEET    1 AD2 5 PHE V 102  VAL V 106  0                                        
SHEET    2 AD2 5 VAL V 307  ASP V 311  1  O  VAL V 307   N  CYS V 103           
SHEET    3 AD2 5 VAL V 335  SER V 340  1  O  VAL V 337   N  ILE V 310           
SHEET    4 AD2 5 ALA V  74  ALA V  78  1  N  LEU V  77   O  LEU V 338           
SHEET    5 AD2 5 LEU V 367  ARG V 371  1  O  LEU V 368   N  LEU V  76           
SHEET    1 AD3 3 ASP V 246  THR V 248  0                                        
SHEET    2 AD3 3 GLY V 130  ARG V 132 -1  N  LEU V 131   O  VAL V 247           
SHEET    3 AD3 3 GLU V 302  ILE V 304 -1  O  ILE V 304   N  GLY V 130           
SHEET    1 AD4 2 THR V 345  THR V 346  0                                        
SHEET    2 AD4 2 ILE V 354  SER V 355 -1  O  SER V 355   N  THR V 345           
SHEET    1 AD5 2 THR W  40  SER W  41  0                                        
SHEET    2 AD5 2 MET W  44  VAL W  45 -1  O  MET W  44   N  SER W  41           
SHEET    1 AD6 5 PHE W  98  ALA W 102  0                                        
SHEET    2 AD6 5 VAL W 292  ASP W 296  1  O  PHE W 294   N  THR W  99           
SHEET    3 AD6 5 ILE W 320  ALA W 324  1  O  MET W 322   N  LEU W 293           
SHEET    4 AD6 5 ALA W  70  ALA W  74  1  N  VAL W  71   O  VAL W 321           
SHEET    5 AD6 5 SER W 351  THR W 355  1  O  ILE W 354   N  LEU W  72           
SHEET    1 AD7 4 GLU W 166  LEU W 171  0                                        
SHEET    2 AD7 4 GLY W 156  LYS W 161 -1  N  GLY W 156   O  LEU W 171           
SHEET    3 AD7 4 GLY W 126  GLN W 144 -1  N  GLN W 144   O  LYS W 157           
SHEET    4 AD7 4 GLN W 230  SER W 240 -1  O  LYS W 231   N  LEU W 135           
SHEET    1 AD8 4 ILE W 199  ARG W 204  0                                        
SHEET    2 AD8 4 ASP W 188  ASP W 193 -1  N  VAL W 189   O  GLY W 203           
SHEET    3 AD8 4 GLY W 126  GLN W 144 -1  N  ILE W 136   O  ILE W 192           
SHEET    4 AD8 4 GLU W 287  VAL W 289 -1  O  GLU W 287   N  LYS W 128           
SHEET    1 AD9 5 PHE X 102  VAL X 106  0                                        
SHEET    2 AD9 5 VAL X 307  ASP X 311  1  O  VAL X 307   N  CYS X 103           
SHEET    3 AD9 5 VAL X 335  SER X 340  1  O  VAL X 337   N  ILE X 310           
SHEET    4 AD9 5 ALA X  74  ALA X  78  1  N  LEU X  77   O  LEU X 338           
SHEET    5 AD9 5 LEU X 367  ARG X 371  1  O  LEU X 368   N  LEU X  76           
SHEET    1 AE1 3 ASP X 246  THR X 248  0                                        
SHEET    2 AE1 3 GLY X 130  ARG X 132 -1  N  LEU X 131   O  VAL X 247           
SHEET    3 AE1 3 GLU X 302  ILE X 304 -1  O  ILE X 304   N  GLY X 130           
SHEET    1 AE2 6 THR X 176  ARG X 180  0                                        
SHEET    2 AE2 6 ILE X 167  LYS X 171 -1  N  VAL X 168   O  LEU X 179           
SHEET    3 AE2 6 GLU X 135  THR X 148 -1  N  GLU X 143   O  LYS X 171           
SHEET    4 AE2 6 ASP X 198  GLU X 203 -1  O  ILE X 202   N  TYR X 140           
SHEET    5 AE2 6 VAL X 209  SER X 215 -1  O  GLY X 213   N  VAL X 199           
SHEET    6 AE2 6 TYR X 229  VAL X 230  1  O  VAL X 230   N  ARG X 214           
SHEET    1 AE3 4 THR X 176  ARG X 180  0                                        
SHEET    2 AE3 4 ILE X 167  LYS X 171 -1  N  VAL X 168   O  LEU X 179           
SHEET    3 AE3 4 GLU X 135  THR X 148 -1  N  GLU X 143   O  LYS X 171           
SHEET    4 AE3 4 HIS X 238  ILE X 243 -1  O  LYS X 239   N  VAL X 139           
SHEET    1 AE4 2 THR X 345  THR X 346  0                                        
SHEET    2 AE4 2 ILE X 354  SER X 355 -1  O  SER X 355   N  THR X 345           
SHEET    1 AE5 2 THR Y  40  SER Y  41  0                                        
SHEET    2 AE5 2 MET Y  44  VAL Y  45 -1  O  MET Y  44   N  SER Y  41           
SHEET    1 AE6 5 PHE Y  98  ALA Y 102  0                                        
SHEET    2 AE6 5 VAL Y 292  ASP Y 296  1  O  PHE Y 294   N  THR Y  99           
SHEET    3 AE6 5 ILE Y 320  ALA Y 324  1  O  MET Y 322   N  LEU Y 293           
SHEET    4 AE6 5 ALA Y  70  ALA Y  74  1  N  VAL Y  71   O  VAL Y 321           
SHEET    5 AE6 5 SER Y 351  THR Y 355  1  O  ILE Y 354   N  LEU Y  72           
SHEET    1 AE7 4 GLU Y 166  LEU Y 171  0                                        
SHEET    2 AE7 4 GLY Y 156  LYS Y 161 -1  N  GLY Y 156   O  LEU Y 171           
SHEET    3 AE7 4 GLY Y 126  GLN Y 144 -1  N  GLN Y 144   O  LYS Y 157           
SHEET    4 AE7 4 GLN Y 230  SER Y 240 -1  O  LYS Y 231   N  LEU Y 135           
SHEET    1 AE8 4 ILE Y 199  ARG Y 204  0                                        
SHEET    2 AE8 4 ASP Y 188  ASP Y 193 -1  N  VAL Y 189   O  GLY Y 203           
SHEET    3 AE8 4 GLY Y 126  GLN Y 144 -1  N  ILE Y 136   O  ILE Y 192           
SHEET    4 AE8 4 GLU Y 287  VAL Y 289 -1  O  GLU Y 287   N  LYS Y 128           
LINK         SG  CYS S 244                ZN    ZN S 501     1555   1555  2.59  
LINK         SG  CYS S 247                ZN    ZN S 501     1555   1555  2.85  
LINK         SG  CYS S 256                ZN    ZN S 502     1555   1555  2.61  
LINK         SG  CYS S 259                ZN    ZN S 502     1555   1555  2.56  
LINK         SG  CYS S 264                ZN    ZN S 501     1555   1555  2.57  
LINK         SG  CYS S 268                ZN    ZN S 501     1555   1555  2.59  
LINK         SG  CYS S 277                ZN    ZN S 502     1555   1555  2.60  
LINK         OE2 GLU U 297                MG    MG U 503     1555   1555  2.99  
LINK         OG1 THR V  86                MG    MG V 502     1555   1555  2.42  
LINK         OE2 GLU W 297                MG    MG W 502     1555   1555  2.85  
LINK         OE2 GLU Y 297                MG    MG Y 503     1555   1555  2.52  
LINK         O1B ADP M1601                BE   BEF M1602     1555   1555  1.40  
LINK         O3B ADP M1601                BE   BEF M1602     1555   1555  2.11  
LINK         O1B ADP R 501                MG    MG R 503     1555   1555  2.17  
LINK         O3B ADP T 501                MG    MG U 501     1555   1555  2.24  
LINK         O2B ADP U 502                MG    MG U 503     1555   1555  2.68  
LINK         O3B ADP V 501                MG    MG V 502     1555   1555  2.92  
LINK         O3B ADP W 501                MG    MG W 502     1555   1555  2.38  
LINK         O3B ADP X 501                MG    MG Y 501     1555   1555  2.18  
LINK         O2B ADP Y 502                MG    MG Y 503     1555   1555  2.39  
SITE     1 AC1 14 ASN M 695  LEU M 696  GLN M 700  GLY M 724                    
SITE     2 AC1 14 LEU M 725  GLY M 726  LYS M 727  THR M 728                    
SITE     3 AC1 14 ILE M 729  ASN M1329  ARG M1357  ILE M1358                    
SITE     4 AC1 14 BEF M1602   MG M1603                                          
SITE     1 AC2  6 MET M 723  LYS M 727  ARG M1354  ARG M1357                    
SITE     2 AC2  6 ADP M1601   MG M1603                                          
SITE     1 AC3  3 ASP M 824  ADP M1601  BEF M1602                               
SITE     1 AC4 14 GLY R  11  SER R  12  TYR R  13  GLU R  14                    
SITE     2 AC4 14 LYS R  16  PHE R 195  ASN R 246  LYS R 249                    
SITE     3 AC4 14 GLU R 250  GLY R 358  ASN R 361  LEU R 362                    
SITE     4 AC4 14 BEF R 502   MG R 503                                          
SITE     1 AC5  6 SER R  12  GLY R 194  PHE R 195  ASN R 196                    
SITE     2 AC5  6 ADP R 501   MG R 503                                          
SITE     1 AC6  2 ADP R 501  BEF R 502                                          
SITE     1 AC7  5 CYS S 244  ILE S 246  CYS S 247  CYS S 264                    
SITE     2 AC7  5 CYS S 268                                                     
SITE     1 AC8  4 CYS S 256  CYS S 259  HIS S 272  CYS S 277                    
SITE     1 AC9 17 ALA T  26  HIS T  29  GLY T  47  PHE T  48                    
SITE     2 AC9 17 VAL T  49  GLY T  80  PRO T  81  SER T  82                    
SITE     3 AC9 17 THR T  83  GLY T  84  LYS T  85  THR T  86                    
SITE     4 AC9 17 ALA T  87  TYR T 375  ARG T 413  GLU U 314                    
SITE     5 AC9 17  MG U 501                                                     
SITE     1 AD1  4 ADP T 501  ASN U 310  GLU U 314  ARG U 350                    
SITE     1 AD2 13 ALA U  22  HIS U  25  VAL U  45  PRO U  76                    
SITE     2 AD2 13 PRO U  77  THR U  79  GLY U  80  LYS U  81                    
SITE     3 AD2 13 THR U  82  TYR U 359  ILE U 367   MG U 503                    
SITE     4 AD2 13 GLU V 329                                                     
SITE     1 AD3  3 THR U  82  GLU U 297  ADP U 502                               
SITE     1 AD4 17 ALA V  26  HIS V  29  GLY V  47  PHE V  48                    
SITE     2 AD4 17 VAL V  49  GLY V  80  PRO V  81  SER V  82                    
SITE     3 AD4 17 THR V  83  GLY V  84  LYS V  85  THR V  86                    
SITE     4 AD4 17 ALA V  87  TYR V 375  ARG V 413   MG V 502                    
SITE     5 AD4 17 GLU W 314                                                     
SITE     1 AD5  2 THR V  86  ADP V 501                                          
SITE     1 AD6 12 ALA W  22  HIS W  25  GLY W  43  VAL W  45                    
SITE     2 AD6 12 PRO W  77  THR W  79  GLY W  80  LYS W  81                    
SITE     3 AD6 12 TYR W 359  ILE W 367   MG W 502  ARG X 366                    
SITE     1 AD7  3 THR W  82  GLU W 297  ADP W 501                               
SITE     1 AD8 18 ALA X  26  HIS X  29  GLY X  47  PHE X  48                    
SITE     2 AD8 18 GLY X  80  PRO X  81  SER X  82  THR X  83                    
SITE     3 AD8 18 GLY X  84  LYS X  85  THR X  86  ALA X  87                    
SITE     4 AD8 18 ILE X 383  ARG X 387  ARG X 413  LEU X 416                    
SITE     5 AD8 18 GLU Y 314   MG Y 501                                          
SITE     1 AD9  3 THR X  86  ADP X 501  GLU Y 314                               
SITE     1 AE1 11 GLU T 329  VAL Y  45  PRO Y  77  SER Y  78                    
SITE     2 AE1 11 GLY Y  80  ASN Y 326  TYR Y 359  ILE Y 367                    
SITE     3 AE1 11 LEU Y 396  ARG Y 397   MG Y 503                               
SITE     1 AE2  3 GLU Y 297  ASN Y 326  ADP Y 502                               
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1           1          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      1.000000  0.000000  0.000000        0.00000                         
SCALE2      0.000000  1.000000  0.000000        0.00000                         
SCALE3      0.000000  0.000000  1.000000        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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