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Database: PDB
Entry: 6GIY
LinkDB: 6GIY
Original site: 6GIY 
HEADER    STRUCTURAL PROTEIN                      15-MAY-18   6GIY              
TITLE     THE BASEPLATE COMPLEX FROM THE TYPE VI SECRETION SYSTEM               
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: TSSF;                                                      
COMPND   3 CHAIN: A, B;                                                         
COMPND   4 ENGINEERED: YES;                                                     
COMPND   5 MOL_ID: 2;                                                           
COMPND   6 MOLECULE: TSSG;                                                      
COMPND   7 CHAIN: C;                                                            
COMPND   8 ENGINEERED: YES;                                                     
COMPND   9 MOL_ID: 3;                                                           
COMPND  10 MOLECULE: TSSK;                                                      
COMPND  11 CHAIN: D, E, F, G, H, I;                                             
COMPND  12 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: ESCHERICHIA COLI;                               
SOURCE   3 ORGANISM_TAXID: 562;                                                 
SOURCE   4 GENE: EC55989_3322;                                                  
SOURCE   5 EXPRESSION_SYSTEM: ESCHERICHIA COLI BL21(DE3);                       
SOURCE   6 EXPRESSION_SYSTEM_TAXID: 469008;                                     
SOURCE   7 MOL_ID: 2;                                                           
SOURCE   8 ORGANISM_SCIENTIFIC: ESCHERICHIA COLI;                               
SOURCE   9 ORGANISM_TAXID: 562;                                                 
SOURCE  10 GENE: EC55989_3321;                                                  
SOURCE  11 EXPRESSION_SYSTEM: ESCHERICHIA COLI BL21(DE3);                       
SOURCE  12 EXPRESSION_SYSTEM_TAXID: 469008;                                     
SOURCE  13 MOL_ID: 3;                                                           
SOURCE  14 ORGANISM_SCIENTIFIC: ESCHERICHIA COLI;                               
SOURCE  15 ORGANISM_TAXID: 562;                                                 
SOURCE  16 GENE: EC55989_3338;                                                  
SOURCE  17 EXPRESSION_SYSTEM: ESCHERICHIA COLI BL21(DE3);                       
SOURCE  18 EXPRESSION_SYSTEM_TAXID: 469008                                      
KEYWDS    SECRETION, BASEPLATE, COMPLEX, STRUCTURAL PROTEIN                     
EXPDTA    ELECTRON MICROSCOPY                                                   
AUTHOR    C.RAPISARDA,R.FRONZES                                                 
REVDAT   4   18-DEC-19 6GIY    1       SCALE                                    
REVDAT   3   05-DEC-18 6GIY    1       JRNL                                     
REVDAT   2   24-OCT-18 6GIY    1       JRNL                                     
REVDAT   1   17-OCT-18 6GIY    0                                                
JRNL        AUTH   Y.CHERRAK,C.RAPISARDA,R.PELLARIN,G.BOUVIER,B.BARDIAUX,       
JRNL        AUTH 2 F.ALLAIN,C.MALOSSE,M.REY,J.CHAMOT-ROOKE,E.CASCALES,          
JRNL        AUTH 3 R.FRONZES,E.DURAND                                           
JRNL        TITL   BIOGENESIS AND STRUCTURE OF A TYPE VI SECRETION BASEPLATE.   
JRNL        REF    NAT MICROBIOL                 V.   3  1404 2018              
JRNL        REFN                   ESSN 2058-5276                               
JRNL        PMID   30323254                                                     
JRNL        DOI    10.1038/S41564-018-0260-1                                    
REMARK   2                                                                      
REMARK   2 RESOLUTION.    4.30 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   SOFTWARE PACKAGES      : EPU, GCTF, UCSF CHIMERA, COOT,            
REMARK   3                            CRYOSPARC, RELION, RELION, PHENIX         
REMARK   3   RECONSTRUCTION SCHEMA  : NULL                                      
REMARK   3                                                                      
REMARK   3 EM MAP-MODEL FITTING AND REFINEMENT                                  
REMARK   3   PDB ENTRY                    : NULL                                
REMARK   3   REFINEMENT SPACE             : REAL                                
REMARK   3   REFINEMENT PROTOCOL          : RIGID BODY FIT                      
REMARK   3   REFINEMENT TARGET            : NULL                                
REMARK   3   OVERALL ANISOTROPIC B VALUE  : NULL                                
REMARK   3                                                                      
REMARK   3 FITTING PROCEDURE : NULL                                             
REMARK   3                                                                      
REMARK   3 EM IMAGE RECONSTRUCTION STATISTICS                                   
REMARK   3   NOMINAL PIXEL SIZE (ANGSTROMS)    : NULL                           
REMARK   3   ACTUAL PIXEL SIZE  (ANGSTROMS)    : NULL                           
REMARK   3   EFFECTIVE RESOLUTION (ANGSTROMS)  : 4.300                          
REMARK   3   NUMBER OF PARTICLES               : 32504                          
REMARK   3   CTF CORRECTION METHOD             : PHASE FLIPPING AND AMPLITUDE   
REMARK   3                                       CORRECTION                     
REMARK   3                                                                      
REMARK   3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL                    
REMARK   3                                                                      
REMARK   3 OTHER DETAILS: NULL                                                  
REMARK   4                                                                      
REMARK   4 6GIY COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 15-MAY-18.                  
REMARK 100 THE DEPOSITION ID IS D_1200010039.                                   
REMARK 245                                                                      
REMARK 245 EXPERIMENTAL DETAILS                                                 
REMARK 245   RECONSTRUCTION METHOD          : SINGLE PARTICLE                   
REMARK 245   SPECIMEN TYPE                  : NULL                              
REMARK 245                                                                      
REMARK 245 ELECTRON MICROSCOPE SAMPLE                                           
REMARK 245   SAMPLE TYPE                    : PARTICLE                          
REMARK 245   PARTICLE TYPE                  : POINT                             
REMARK 245   NAME OF SAMPLE                 : COMPLEX OF TSSK, TSSF AND TSSG,   
REMARK 245                                    COMPONENTS OF THE TYPE VI         
REMARK 245                                    SECRETION SYSTEM BASEPLATE        
REMARK 245   SAMPLE CONCENTRATION (MG ML-1) : 0.20                              
REMARK 245   SAMPLE SUPPORT DETAILS         : NULL                              
REMARK 245   SAMPLE VITRIFICATION DETAILS   : NULL                              
REMARK 245   SAMPLE BUFFER                  : NULL                              
REMARK 245   PH                             : 7.50                              
REMARK 245   SAMPLE DETAILS                 : NULL                              
REMARK 245                                                                      
REMARK 245 DATA ACQUISITION                                                     
REMARK 245   DATE OF EXPERIMENT                : NULL                           
REMARK 245   NUMBER OF MICROGRAPHS-IMAGES      : NULL                           
REMARK 245   TEMPERATURE (KELVIN)              : NULL                           
REMARK 245   MICROSCOPE MODEL                  : FEI TITAN KRIOS                
REMARK 245   DETECTOR TYPE                     : GATAN K2 SUMMIT (4K X 4K)      
REMARK 245   MINIMUM DEFOCUS (NM)              : 700.00                         
REMARK 245   MAXIMUM DEFOCUS (NM)              : 2000.00                        
REMARK 245   MINIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   MAXIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   NOMINAL CS                        : 2.70                           
REMARK 245   IMAGING MODE                      : BRIGHT FIELD                   
REMARK 245   ELECTRON DOSE (ELECTRONS NM**-2)  : 1.50                           
REMARK 245   ILLUMINATION MODE                 : FLOOD BEAM                     
REMARK 245   NOMINAL MAGNIFICATION             : 130000                         
REMARK 245   CALIBRATED MAGNIFICATION          : NULL                           
REMARK 245   SOURCE                            : FIELD EMISSION GUN             
REMARK 245   ACCELERATION VOLTAGE (KV)         : 300                            
REMARK 245   IMAGING DETAILS                   : NULL                           
REMARK 247                                                                      
REMARK 247 ELECTRON MICROSCOPY                                                  
REMARK 247  THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON          
REMARK 247  MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE              
REMARK 247  THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES           
REMARK 247  ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION         
REMARK 247  OF THE STRUCTURE FACTORS.                                           
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: NONAMERIC                         
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: NONAMERIC                  
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 57540 ANGSTROM**2                         
REMARK 350 SURFACE AREA OF THE COMPLEX: 181310 ANGSTROM**2                      
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -295.0 KCAL/MOL                       
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E, F, G, H, I             
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     MET A     1                                                      
REMARK 465     ASP A     2                                                      
REMARK 465     ASP A     3                                                      
REMARK 465     MET B     1                                                      
REMARK 465     ASP B     2                                                      
REMARK 465     ASP B     3                                                      
REMARK 465     GLY B   587                                                      
REMARK 465     MET C     1                                                      
REMARK 465     HIS C     2                                                      
REMARK 465     PRO C     3                                                      
REMARK 465     VAL C     4                                                      
REMARK 465     GLU C     5                                                      
REMARK 465     ARG C     6                                                      
REMARK 465     LYS C     7                                                      
REMARK 465     THR C   358                                                      
REMARK 465     GLN C   359                                                      
REMARK 465     GLU C   360                                                      
REMARK 465     ASN C   361                                                      
REMARK 465     GLY C   362                                                      
REMARK 465     ASP C   363                                                      
REMARK 465     TYR C   364                                                      
REMARK 465     ARG C   365                                                      
REMARK 465     TRP C   366                                                      
REMARK 465     ALA D   312                                                      
REMARK 465     SER D   313                                                      
REMARK 465     LEU D   314                                                      
REMARK 465     PRO D   315                                                      
REMARK 465     SER D   316                                                      
REMARK 465     ARG D   317                                                      
REMARK 465     VAL D   318                                                      
REMARK 465     VAL D   319                                                      
REMARK 465     PHE D   320                                                      
REMARK 465     ILE D   321                                                      
REMARK 465     GLU D   322                                                      
REMARK 465     LEU D   323                                                      
REMARK 465     LYS D   324                                                      
REMARK 465     GLN D   325                                                      
REMARK 465     LYS D   326                                                      
REMARK 465     GLY D   327                                                      
REMARK 465     VAL D   328                                                      
REMARK 465     MET D   329                                                      
REMARK 465     TRP D   330                                                      
REMARK 465     GLU D   331                                                      
REMARK 465     GLY D   332                                                      
REMARK 465     ALA D   333                                                      
REMARK 465     LEU D   334                                                      
REMARK 465     HIS D   335                                                      
REMARK 465     ASP D   336                                                      
REMARK 465     ALA D   337                                                      
REMARK 465     ARG D   338                                                      
REMARK 465     LEU D   339                                                      
REMARK 465     ARG D   340                                                      
REMARK 465     GLU D   341                                                      
REMARK 465     GLY D   342                                                      
REMARK 465     ALA D   343                                                      
REMARK 465     ASP D   344                                                      
REMARK 465     PHE D   345                                                      
REMARK 465     TRP D   346                                                      
REMARK 465     LEU D   347                                                      
REMARK 465     SER D   348                                                      
REMARK 465     VAL D   349                                                      
REMARK 465     ARG D   350                                                      
REMARK 465     SER D   351                                                      
REMARK 465     SER D   352                                                      
REMARK 465     MET D   353                                                      
REMARK 465     PRO D   354                                                      
REMARK 465     GLY D   355                                                      
REMARK 465     HIS D   356                                                      
REMARK 465     GLU D   357                                                      
REMARK 465     LEU D   358                                                      
REMARK 465     GLN D   359                                                      
REMARK 465     THR D   360                                                      
REMARK 465     LYS D   361                                                      
REMARK 465     PHE D   362                                                      
REMARK 465     PRO D   363                                                      
REMARK 465     GLN D   364                                                      
REMARK 465     LEU D   365                                                      
REMARK 465     CYS D   366                                                      
REMARK 465     LYS D   367                                                      
REMARK 465     ALA D   368                                                      
REMARK 465     GLY D   369                                                      
REMARK 465     SER D   370                                                      
REMARK 465     PRO D   371                                                      
REMARK 465     ASP D   372                                                      
REMARK 465     ASP D   373                                                      
REMARK 465     VAL D   374                                                      
REMARK 465     SER D   375                                                      
REMARK 465     GLU D   376                                                      
REMARK 465     VAL D   377                                                      
REMARK 465     VAL D   378                                                      
REMARK 465     ASN D   379                                                      
REMARK 465     VAL D   380                                                      
REMARK 465     ALA D   381                                                      
REMARK 465     LEU D   382                                                      
REMARK 465     SER D   383                                                      
REMARK 465     GLY D   384                                                      
REMARK 465     VAL D   385                                                      
REMARK 465     ILE D   386                                                      
REMARK 465     ILE D   387                                                      
REMARK 465     ARG D   388                                                      
REMARK 465     PRO D   389                                                      
REMARK 465     VAL D   390                                                      
REMARK 465     THR D   391                                                      
REMARK 465     HIS D   392                                                      
REMARK 465     VAL D   393                                                      
REMARK 465     PRO D   394                                                      
REMARK 465     ALA D   395                                                      
REMARK 465     ALA D   396                                                      
REMARK 465     ILE D   397                                                      
REMARK 465     PRO D   398                                                      
REMARK 465     LEU D   399                                                      
REMARK 465     ARG D   400                                                      
REMARK 465     LEU D   401                                                      
REMARK 465     GLU D   402                                                      
REMARK 465     ASN D   403                                                      
REMARK 465     GLN D   404                                                      
REMARK 465     TYR D   405                                                      
REMARK 465     PHE D   406                                                      
REMARK 465     ALA D   407                                                      
REMARK 465     LEU D   408                                                      
REMARK 465     ASP D   409                                                      
REMARK 465     LEU D   410                                                      
REMARK 465     SER D   411                                                      
REMARK 465     THR D   412                                                      
REMARK 465     ASP D   413                                                      
REMARK 465     ALA D   414                                                      
REMARK 465     ALA D   415                                                      
REMARK 465     ARG D   416                                                      
REMARK 465     ALA D   417                                                      
REMARK 465     MET D   418                                                      
REMARK 465     LEU D   419                                                      
REMARK 465     ASP D   420                                                      
REMARK 465     ALA D   421                                                      
REMARK 465     GLY D   422                                                      
REMARK 465     ARG D   423                                                      
REMARK 465     CYS D   424                                                      
REMARK 465     THR D   425                                                      
REMARK 465     PHE D   426                                                      
REMARK 465     TYR D   427                                                      
REMARK 465     THR D   428                                                      
REMARK 465     PRO D   429                                                      
REMARK 465     ALA D   430                                                      
REMARK 465     SER D   431                                                      
REMARK 465     LEU D   432                                                      
REMARK 465     GLY D   433                                                      
REMARK 465     ASP D   434                                                      
REMARK 465     VAL D   435                                                      
REMARK 465     LYS D   436                                                      
REMARK 465     LEU D   437                                                      
REMARK 465     GLU D   438                                                      
REMARK 465     LEU D   439                                                      
REMARK 465     PHE D   440                                                      
REMARK 465     ALA D   441                                                      
REMARK 465     VAL D   442                                                      
REMARK 465     LEU D   443                                                      
REMARK 465     ARG D   444                                                      
REMARK 465     ALA E   312                                                      
REMARK 465     SER E   313                                                      
REMARK 465     LEU E   314                                                      
REMARK 465     PRO E   315                                                      
REMARK 465     SER E   316                                                      
REMARK 465     ARG E   317                                                      
REMARK 465     VAL E   318                                                      
REMARK 465     VAL E   319                                                      
REMARK 465     PHE E   320                                                      
REMARK 465     ILE E   321                                                      
REMARK 465     GLU E   322                                                      
REMARK 465     LEU E   323                                                      
REMARK 465     LYS E   324                                                      
REMARK 465     GLN E   325                                                      
REMARK 465     LYS E   326                                                      
REMARK 465     GLY E   327                                                      
REMARK 465     VAL E   328                                                      
REMARK 465     MET E   329                                                      
REMARK 465     TRP E   330                                                      
REMARK 465     GLU E   331                                                      
REMARK 465     GLY E   332                                                      
REMARK 465     ALA E   333                                                      
REMARK 465     LEU E   334                                                      
REMARK 465     HIS E   335                                                      
REMARK 465     ASP E   336                                                      
REMARK 465     ALA E   337                                                      
REMARK 465     ARG E   338                                                      
REMARK 465     LEU E   339                                                      
REMARK 465     ARG E   340                                                      
REMARK 465     GLU E   341                                                      
REMARK 465     GLY E   342                                                      
REMARK 465     ALA E   343                                                      
REMARK 465     ASP E   344                                                      
REMARK 465     PHE E   345                                                      
REMARK 465     TRP E   346                                                      
REMARK 465     LEU E   347                                                      
REMARK 465     SER E   348                                                      
REMARK 465     VAL E   349                                                      
REMARK 465     ARG E   350                                                      
REMARK 465     SER E   351                                                      
REMARK 465     SER E   352                                                      
REMARK 465     MET E   353                                                      
REMARK 465     PRO E   354                                                      
REMARK 465     GLY E   355                                                      
REMARK 465     HIS E   356                                                      
REMARK 465     GLU E   357                                                      
REMARK 465     LEU E   358                                                      
REMARK 465     GLN E   359                                                      
REMARK 465     THR E   360                                                      
REMARK 465     LYS E   361                                                      
REMARK 465     PHE E   362                                                      
REMARK 465     PRO E   363                                                      
REMARK 465     GLN E   364                                                      
REMARK 465     LEU E   365                                                      
REMARK 465     CYS E   366                                                      
REMARK 465     LYS E   367                                                      
REMARK 465     ALA E   368                                                      
REMARK 465     GLY E   369                                                      
REMARK 465     SER E   370                                                      
REMARK 465     PRO E   371                                                      
REMARK 465     ASP E   372                                                      
REMARK 465     ASP E   373                                                      
REMARK 465     VAL E   374                                                      
REMARK 465     SER E   375                                                      
REMARK 465     GLU E   376                                                      
REMARK 465     VAL E   377                                                      
REMARK 465     VAL E   378                                                      
REMARK 465     ASN E   379                                                      
REMARK 465     VAL E   380                                                      
REMARK 465     ALA E   381                                                      
REMARK 465     LEU E   382                                                      
REMARK 465     SER E   383                                                      
REMARK 465     GLY E   384                                                      
REMARK 465     VAL E   385                                                      
REMARK 465     ILE E   386                                                      
REMARK 465     ILE E   387                                                      
REMARK 465     ARG E   388                                                      
REMARK 465     PRO E   389                                                      
REMARK 465     VAL E   390                                                      
REMARK 465     THR E   391                                                      
REMARK 465     HIS E   392                                                      
REMARK 465     VAL E   393                                                      
REMARK 465     PRO E   394                                                      
REMARK 465     ALA E   395                                                      
REMARK 465     ALA E   396                                                      
REMARK 465     ILE E   397                                                      
REMARK 465     PRO E   398                                                      
REMARK 465     LEU E   399                                                      
REMARK 465     ARG E   400                                                      
REMARK 465     LEU E   401                                                      
REMARK 465     GLU E   402                                                      
REMARK 465     ASN E   403                                                      
REMARK 465     GLN E   404                                                      
REMARK 465     TYR E   405                                                      
REMARK 465     PHE E   406                                                      
REMARK 465     ALA E   407                                                      
REMARK 465     LEU E   408                                                      
REMARK 465     ASP E   409                                                      
REMARK 465     LEU E   410                                                      
REMARK 465     SER E   411                                                      
REMARK 465     THR E   412                                                      
REMARK 465     ASP E   413                                                      
REMARK 465     ALA E   414                                                      
REMARK 465     ALA E   415                                                      
REMARK 465     ARG E   416                                                      
REMARK 465     ALA E   417                                                      
REMARK 465     MET E   418                                                      
REMARK 465     LEU E   419                                                      
REMARK 465     ASP E   420                                                      
REMARK 465     ALA E   421                                                      
REMARK 465     GLY E   422                                                      
REMARK 465     ARG E   423                                                      
REMARK 465     CYS E   424                                                      
REMARK 465     THR E   425                                                      
REMARK 465     PHE E   426                                                      
REMARK 465     TYR E   427                                                      
REMARK 465     THR E   428                                                      
REMARK 465     PRO E   429                                                      
REMARK 465     ALA E   430                                                      
REMARK 465     SER E   431                                                      
REMARK 465     LEU E   432                                                      
REMARK 465     GLY E   433                                                      
REMARK 465     ASP E   434                                                      
REMARK 465     VAL E   435                                                      
REMARK 465     LYS E   436                                                      
REMARK 465     LEU E   437                                                      
REMARK 465     GLU E   438                                                      
REMARK 465     LEU E   439                                                      
REMARK 465     PHE E   440                                                      
REMARK 465     ALA E   441                                                      
REMARK 465     VAL E   442                                                      
REMARK 465     LEU E   443                                                      
REMARK 465     ARG E   444                                                      
REMARK 465     ALA F   312                                                      
REMARK 465     SER F   313                                                      
REMARK 465     LEU F   314                                                      
REMARK 465     PRO F   315                                                      
REMARK 465     SER F   316                                                      
REMARK 465     ARG F   317                                                      
REMARK 465     VAL F   318                                                      
REMARK 465     VAL F   319                                                      
REMARK 465     PHE F   320                                                      
REMARK 465     ILE F   321                                                      
REMARK 465     GLU F   322                                                      
REMARK 465     LEU F   323                                                      
REMARK 465     LYS F   324                                                      
REMARK 465     GLN F   325                                                      
REMARK 465     LYS F   326                                                      
REMARK 465     GLY F   327                                                      
REMARK 465     VAL F   328                                                      
REMARK 465     MET F   329                                                      
REMARK 465     TRP F   330                                                      
REMARK 465     GLU F   331                                                      
REMARK 465     GLY F   332                                                      
REMARK 465     ALA F   333                                                      
REMARK 465     LEU F   334                                                      
REMARK 465     HIS F   335                                                      
REMARK 465     ASP F   336                                                      
REMARK 465     ALA F   337                                                      
REMARK 465     ARG F   338                                                      
REMARK 465     LEU F   339                                                      
REMARK 465     ARG F   340                                                      
REMARK 465     GLU F   341                                                      
REMARK 465     GLY F   342                                                      
REMARK 465     ALA F   343                                                      
REMARK 465     ASP F   344                                                      
REMARK 465     PHE F   345                                                      
REMARK 465     TRP F   346                                                      
REMARK 465     LEU F   347                                                      
REMARK 465     SER F   348                                                      
REMARK 465     VAL F   349                                                      
REMARK 465     ARG F   350                                                      
REMARK 465     SER F   351                                                      
REMARK 465     SER F   352                                                      
REMARK 465     MET F   353                                                      
REMARK 465     PRO F   354                                                      
REMARK 465     GLY F   355                                                      
REMARK 465     HIS F   356                                                      
REMARK 465     GLU F   357                                                      
REMARK 465     LEU F   358                                                      
REMARK 465     GLN F   359                                                      
REMARK 465     THR F   360                                                      
REMARK 465     LYS F   361                                                      
REMARK 465     PHE F   362                                                      
REMARK 465     PRO F   363                                                      
REMARK 465     GLN F   364                                                      
REMARK 465     LEU F   365                                                      
REMARK 465     CYS F   366                                                      
REMARK 465     LYS F   367                                                      
REMARK 465     ALA F   368                                                      
REMARK 465     GLY F   369                                                      
REMARK 465     SER F   370                                                      
REMARK 465     PRO F   371                                                      
REMARK 465     ASP F   372                                                      
REMARK 465     ASP F   373                                                      
REMARK 465     VAL F   374                                                      
REMARK 465     SER F   375                                                      
REMARK 465     GLU F   376                                                      
REMARK 465     VAL F   377                                                      
REMARK 465     VAL F   378                                                      
REMARK 465     ASN F   379                                                      
REMARK 465     VAL F   380                                                      
REMARK 465     ALA F   381                                                      
REMARK 465     LEU F   382                                                      
REMARK 465     SER F   383                                                      
REMARK 465     GLY F   384                                                      
REMARK 465     VAL F   385                                                      
REMARK 465     ILE F   386                                                      
REMARK 465     ILE F   387                                                      
REMARK 465     ARG F   388                                                      
REMARK 465     PRO F   389                                                      
REMARK 465     VAL F   390                                                      
REMARK 465     THR F   391                                                      
REMARK 465     HIS F   392                                                      
REMARK 465     VAL F   393                                                      
REMARK 465     PRO F   394                                                      
REMARK 465     ALA F   395                                                      
REMARK 465     ALA F   396                                                      
REMARK 465     ILE F   397                                                      
REMARK 465     PRO F   398                                                      
REMARK 465     LEU F   399                                                      
REMARK 465     ARG F   400                                                      
REMARK 465     LEU F   401                                                      
REMARK 465     GLU F   402                                                      
REMARK 465     ASN F   403                                                      
REMARK 465     GLN F   404                                                      
REMARK 465     TYR F   405                                                      
REMARK 465     PHE F   406                                                      
REMARK 465     ALA F   407                                                      
REMARK 465     LEU F   408                                                      
REMARK 465     ASP F   409                                                      
REMARK 465     LEU F   410                                                      
REMARK 465     SER F   411                                                      
REMARK 465     THR F   412                                                      
REMARK 465     ASP F   413                                                      
REMARK 465     ALA F   414                                                      
REMARK 465     ALA F   415                                                      
REMARK 465     ARG F   416                                                      
REMARK 465     ALA F   417                                                      
REMARK 465     MET F   418                                                      
REMARK 465     LEU F   419                                                      
REMARK 465     ASP F   420                                                      
REMARK 465     ALA F   421                                                      
REMARK 465     GLY F   422                                                      
REMARK 465     ARG F   423                                                      
REMARK 465     CYS F   424                                                      
REMARK 465     THR F   425                                                      
REMARK 465     PHE F   426                                                      
REMARK 465     TYR F   427                                                      
REMARK 465     THR F   428                                                      
REMARK 465     PRO F   429                                                      
REMARK 465     ALA F   430                                                      
REMARK 465     SER F   431                                                      
REMARK 465     LEU F   432                                                      
REMARK 465     GLY F   433                                                      
REMARK 465     ASP F   434                                                      
REMARK 465     VAL F   435                                                      
REMARK 465     LYS F   436                                                      
REMARK 465     LEU F   437                                                      
REMARK 465     GLU F   438                                                      
REMARK 465     LEU F   439                                                      
REMARK 465     PHE F   440                                                      
REMARK 465     ALA F   441                                                      
REMARK 465     VAL F   442                                                      
REMARK 465     LEU F   443                                                      
REMARK 465     ARG F   444                                                      
REMARK 465     ALA I   312                                                      
REMARK 465     SER I   313                                                      
REMARK 465     LEU I   314                                                      
REMARK 465     PRO I   315                                                      
REMARK 465     SER I   316                                                      
REMARK 465     ARG I   317                                                      
REMARK 465     VAL I   318                                                      
REMARK 465     VAL I   319                                                      
REMARK 465     PHE I   320                                                      
REMARK 465     ILE I   321                                                      
REMARK 465     GLU I   322                                                      
REMARK 465     LEU I   323                                                      
REMARK 465     LYS I   324                                                      
REMARK 465     GLN I   325                                                      
REMARK 465     LYS I   326                                                      
REMARK 465     GLY I   327                                                      
REMARK 465     VAL I   328                                                      
REMARK 465     MET I   329                                                      
REMARK 465     TRP I   330                                                      
REMARK 465     GLU I   331                                                      
REMARK 465     GLY I   332                                                      
REMARK 465     ALA I   333                                                      
REMARK 465     LEU I   334                                                      
REMARK 465     HIS I   335                                                      
REMARK 465     ASP I   336                                                      
REMARK 465     ALA I   337                                                      
REMARK 465     ARG I   338                                                      
REMARK 465     LEU I   339                                                      
REMARK 465     ARG I   340                                                      
REMARK 465     GLU I   341                                                      
REMARK 465     GLY I   342                                                      
REMARK 465     ALA I   343                                                      
REMARK 465     ASP I   344                                                      
REMARK 465     PHE I   345                                                      
REMARK 465     TRP I   346                                                      
REMARK 465     LEU I   347                                                      
REMARK 465     SER I   348                                                      
REMARK 465     VAL I   349                                                      
REMARK 465     ARG I   350                                                      
REMARK 465     SER I   351                                                      
REMARK 465     SER I   352                                                      
REMARK 465     MET I   353                                                      
REMARK 465     PRO I   354                                                      
REMARK 465     GLY I   355                                                      
REMARK 465     HIS I   356                                                      
REMARK 465     GLU I   357                                                      
REMARK 465     LEU I   358                                                      
REMARK 465     GLN I   359                                                      
REMARK 465     THR I   360                                                      
REMARK 465     LYS I   361                                                      
REMARK 465     PHE I   362                                                      
REMARK 465     PRO I   363                                                      
REMARK 465     GLN I   364                                                      
REMARK 465     LEU I   365                                                      
REMARK 465     CYS I   366                                                      
REMARK 465     LYS I   367                                                      
REMARK 465     ALA I   368                                                      
REMARK 465     GLY I   369                                                      
REMARK 465     SER I   370                                                      
REMARK 465     PRO I   371                                                      
REMARK 465     ASP I   372                                                      
REMARK 465     ASP I   373                                                      
REMARK 465     VAL I   374                                                      
REMARK 465     SER I   375                                                      
REMARK 465     GLU I   376                                                      
REMARK 465     VAL I   377                                                      
REMARK 465     VAL I   378                                                      
REMARK 465     ASN I   379                                                      
REMARK 465     VAL I   380                                                      
REMARK 465     ALA I   381                                                      
REMARK 465     LEU I   382                                                      
REMARK 465     SER I   383                                                      
REMARK 465     GLY I   384                                                      
REMARK 465     VAL I   385                                                      
REMARK 465     ILE I   386                                                      
REMARK 465     ILE I   387                                                      
REMARK 465     ARG I   388                                                      
REMARK 465     PRO I   389                                                      
REMARK 465     VAL I   390                                                      
REMARK 465     THR I   391                                                      
REMARK 465     HIS I   392                                                      
REMARK 465     VAL I   393                                                      
REMARK 465     PRO I   394                                                      
REMARK 465     ALA I   395                                                      
REMARK 465     ALA I   396                                                      
REMARK 465     ILE I   397                                                      
REMARK 465     PRO I   398                                                      
REMARK 465     LEU I   399                                                      
REMARK 465     ARG I   400                                                      
REMARK 465     LEU I   401                                                      
REMARK 465     GLU I   402                                                      
REMARK 465     ASN I   403                                                      
REMARK 465     GLN I   404                                                      
REMARK 465     TYR I   405                                                      
REMARK 465     PHE I   406                                                      
REMARK 465     ALA I   407                                                      
REMARK 465     LEU I   408                                                      
REMARK 465     ASP I   409                                                      
REMARK 465     LEU I   410                                                      
REMARK 465     SER I   411                                                      
REMARK 465     THR I   412                                                      
REMARK 465     ASP I   413                                                      
REMARK 465     ALA I   414                                                      
REMARK 465     ALA I   415                                                      
REMARK 465     ARG I   416                                                      
REMARK 465     ALA I   417                                                      
REMARK 465     MET I   418                                                      
REMARK 465     LEU I   419                                                      
REMARK 465     ASP I   420                                                      
REMARK 465     ALA I   421                                                      
REMARK 465     GLY I   422                                                      
REMARK 465     ARG I   423                                                      
REMARK 465     CYS I   424                                                      
REMARK 465     THR I   425                                                      
REMARK 465     PHE I   426                                                      
REMARK 465     TYR I   427                                                      
REMARK 465     THR I   428                                                      
REMARK 465     PRO I   429                                                      
REMARK 465     ALA I   430                                                      
REMARK 465     SER I   431                                                      
REMARK 465     LEU I   432                                                      
REMARK 465     GLY I   433                                                      
REMARK 465     ASP I   434                                                      
REMARK 465     VAL I   435                                                      
REMARK 465     LYS I   436                                                      
REMARK 465     LEU I   437                                                      
REMARK 465     GLU I   438                                                      
REMARK 465     LEU I   439                                                      
REMARK 465     PHE I   440                                                      
REMARK 465     ALA I   441                                                      
REMARK 465     VAL I   442                                                      
REMARK 465     LEU I   443                                                      
REMARK 465     ARG I   444                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     SER C 334    OG                                                  
REMARK 470     ARG C 337    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     VAL C 338    CG1  CG2                                            
REMARK 470     MET C 339    CG   SD   CE                                        
REMARK 470     THR C 340    OG1  CG2                                            
REMARK 470     ILE C 341    CG1  CG2  CD1                                       
REMARK 470     SER C 342    OG                                                  
REMARK 470     LEU C 343    CG   CD1  CD2                                       
REMARK 470     ASN D 222    CG   OD1  ND2                                       
REMARK 470     ASN D 223    CG   OD1  ND2                                       
REMARK 470     ARG D 225    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG E 225    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASN F 159    CG   OD1  ND2                                       
REMARK 470     LEU H 334    CG   CD1  CD2                                       
REMARK 470     HIS H 335    CG   ND1  CD2  CE1  NE2                             
REMARK 470     LEU H 347    CG   CD1  CD2                                       
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500    TYR C 346   C   -  N   -  CA  ANGL. DEV. =  15.1 DEGREES          
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    PRO A 109       52.14    -91.55                                   
REMARK 500    GLU A 113     -168.21   -125.91                                   
REMARK 500    SER A 154      111.33   -160.49                                   
REMARK 500    GLU A 164       37.67    -93.10                                   
REMARK 500    TYR A 202       30.82    -89.06                                   
REMARK 500    ASN A 208       28.96   -143.23                                   
REMARK 500    ARG A 213       14.67     56.25                                   
REMARK 500    GLU A 226       32.21    -91.39                                   
REMARK 500    TYR A 240       23.78   -141.51                                   
REMARK 500    HIS A 257       58.43    -97.96                                   
REMARK 500    GLU A 276      -11.02   -140.23                                   
REMARK 500    ASP A 291       54.14    -96.48                                   
REMARK 500    TYR A 321      -39.57   -132.75                                   
REMARK 500    ARG A 346      -60.02   -100.10                                   
REMARK 500    HIS A 360       67.71     61.21                                   
REMARK 500    TYR A 374      108.22   -162.39                                   
REMARK 500    ASP A 387      139.33   -170.63                                   
REMARK 500    THR A 388      119.70   -164.04                                   
REMARK 500    GLU A 398       77.31   -100.48                                   
REMARK 500    VAL A 435      -76.01    -97.60                                   
REMARK 500    LEU A 436       63.92     21.68                                   
REMARK 500    LEU A 476     -159.48    -79.59                                   
REMARK 500    LEU A 501       53.39    -90.51                                   
REMARK 500    ASP A 531      125.52    -32.65                                   
REMARK 500    GLN A 569      153.54    -49.57                                   
REMARK 500    PRO A 570       78.11    -66.03                                   
REMARK 500    PRO B  28        5.52    -64.90                                   
REMARK 500    LEU B  68       73.96     52.60                                   
REMARK 500    LEU B  84        5.63    -68.20                                   
REMARK 500    PRO B  88     -168.88    -76.93                                   
REMARK 500    MET B 102      112.82   -161.83                                   
REMARK 500    ALA B 161      -60.37    -93.30                                   
REMARK 500    ALA B 181     -161.57    -79.40                                   
REMARK 500    ALA B 182       22.73    -78.02                                   
REMARK 500    SER B 187       49.01    -85.30                                   
REMARK 500    SER B 188       -2.47   -141.30                                   
REMARK 500    SER B 238      108.55    -55.49                                   
REMARK 500    PHE B 247       66.78     61.25                                   
REMARK 500    THR B 248      -17.39   -140.11                                   
REMARK 500    PHE B 249       70.11     45.22                                   
REMARK 500    MET B 254       77.01     57.84                                   
REMARK 500    PHE B 255      117.31    -34.61                                   
REMARK 500    ASN B 259     -168.02    -75.34                                   
REMARK 500    LEU B 275       45.09   -141.00                                   
REMARK 500    LEU B 317     -165.17   -125.97                                   
REMARK 500    TYR B 321       30.48   -140.39                                   
REMARK 500    VAL B 353       72.73     57.21                                   
REMARK 500    TYR B 373     -169.31   -118.87                                   
REMARK 500    GLN B 418     -167.21   -161.53                                   
REMARK 500    HIS B 461        4.55    -69.47                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     163 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS                                         
REMARK 500                                                                      
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH          
REMARK 500 CIS AND TRANS CONFORMATION.  CIS BONDS, IF ANY, ARE LISTED           
REMARK 500 ON CISPEP RECORDS.  TRANS IS DEFINED AS 180 +/- 30 AND               
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.                                  
REMARK 500                                 MODEL     OMEGA                      
REMARK 500 LEU A  178     TYR A  179                 -149.25                    
REMARK 500 GLU A  276     VAL A  277                 -148.02                    
REMARK 500 HIS A  360     ARG A  361                  147.57                    
REMARK 500 LEU A  390     ILE A  391                 -149.74                    
REMARK 500 VAL A  435     LEU A  436                  128.27                    
REMARK 500 TYR A  453     PRO A  454                  144.82                    
REMARK 500 ILE A  504     LEU A  505                 -145.41                    
REMARK 500 LEU A  530     ASP A  531                 -140.87                    
REMARK 500 ASN A  562     GLN A  563                 -145.89                    
REMARK 500 TRP B   80     PRO B   81                  147.52                    
REMARK 500 ARG B  117     PRO B  118                 -149.84                    
REMARK 500 PHE B  247     THR B  248                  141.58                    
REMARK 500 LEU B  275     GLU B  276                 -149.96                    
REMARK 500 PHE B  515     GLU B  516                  149.05                    
REMARK 500 ARG B  576     TRP B  577                 -147.28                    
REMARK 500 LYS B  578     GLU B  579                  147.67                    
REMARK 500 GLU B  579     ASN B  580                  140.79                    
REMARK 500 GLN C  110     GLN C  111                 -149.32                    
REMARK 500 TYR C  142     PRO C  143                 -130.38                    
REMARK 500 ILE C  166     PRO C  167                  145.78                    
REMARK 500 ARG C  219     ILE C  220                 -117.54                    
REMARK 500 ILE C  220     PRO C  221                 -115.79                    
REMARK 500 LYS C  237     SER C  238                 -137.66                    
REMARK 500 VAL C  249     ASN C  250                  147.71                    
REMARK 500 GLU C  299     ARG C  300                 -133.17                    
REMARK 500 ASP C  305     ALA C  306                 -138.50                    
REMARK 500 LEU C  308     SER C  309                 -132.28                    
REMARK 500 CYS C  310     ARG C  311                  123.12                    
REMARK 500 GLN C  328     ALA C  329                 -149.56                    
REMARK 500 TYR C  346     GLN C  347                  135.98                    
REMARK 500 GLN C  347     ARG C  348                 -118.04                    
REMARK 500 THR E  190     LEU E  191                 -141.66                    
REMARK 500 HIS F   40     PRO F   41                  144.61                    
REMARK 500 TRP F  162     LEU F  163                 -125.68                    
REMARK 500 HIS G   40     PRO G   41                  130.73                    
REMARK 500 GLN G  133     GLU G  134                 -132.07                    
REMARK 500 ALA G  155     HIS G  156                 -142.42                    
REMARK 500 ALA G  160     ALA G  161                  146.98                    
REMARK 500 MET G  256     PRO G  257                 -138.39                    
REMARK 500 LEU H   56     SER H   57                 -136.77                    
REMARK 500 ALA I   12     PHE I   13                 -146.58                    
REMARK 500 PRO I   41     TRP I   42                 -146.88                    
REMARK 500 LEU I   56     SER I   57                 -133.44                    
REMARK 500 GLU I  139     GLN I  140                 -147.99                    
REMARK 500 ALA I  160     ALA I  161                  148.98                    
REMARK 500 PRO I  186     PRO I  187                 -144.11                    
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: EMD-0008   RELATED DB: EMDB                              
REMARK 900 THE BASEPLATE COMPLEX FROM THE TYPE VI SECRETION SYSTEM              
DBREF  6GIY A    1   587  UNP    B7LFT7   B7LFT7_ECO55     1    587             
DBREF  6GIY B    1   587  UNP    B7LFT7   B7LFT7_ECO55     1    587             
DBREF  6GIY C    1   366  UNP    B7LFT6   B7LFT6_ECO55     1    366             
DBREF  6GIY D    1   444  UNP    B7LG64   B7LG64_ECO55     1    444             
DBREF  6GIY E    1   444  UNP    B7LG64   B7LG64_ECO55     1    444             
DBREF  6GIY F    1   444  UNP    B7LG64   B7LG64_ECO55     1    444             
DBREF  6GIY G    1   444  UNP    B7LG64   B7LG64_ECO55     1    444             
DBREF  6GIY H    1   444  UNP    B7LG64   B7LG64_ECO55     1    444             
DBREF  6GIY I    1   444  UNP    B7LG64   B7LG64_ECO55     1    444             
SEQADV 6GIY SER D  194  UNP  B7LG64    GLY   194 CONFLICT                       
SEQADV 6GIY LEU D  202  UNP  B7LG64    ALA   202 CONFLICT                       
SEQADV 6GIY SER E  194  UNP  B7LG64    GLY   194 CONFLICT                       
SEQADV 6GIY LEU E  202  UNP  B7LG64    ALA   202 CONFLICT                       
SEQADV 6GIY SER F  194  UNP  B7LG64    GLY   194 CONFLICT                       
SEQADV 6GIY LEU F  202  UNP  B7LG64    ALA   202 CONFLICT                       
SEQADV 6GIY SER G  194  UNP  B7LG64    GLY   194 CONFLICT                       
SEQADV 6GIY LEU G  202  UNP  B7LG64    ALA   202 CONFLICT                       
SEQADV 6GIY SER H  194  UNP  B7LG64    GLY   194 CONFLICT                       
SEQADV 6GIY LEU H  202  UNP  B7LG64    ALA   202 CONFLICT                       
SEQADV 6GIY SER I  194  UNP  B7LG64    GLY   194 CONFLICT                       
SEQADV 6GIY LEU I  202  UNP  B7LG64    ALA   202 CONFLICT                       
SEQRES   1 A  587  MET ASP ASP LEU THR LEU ARG TYR PHE ASP ALA GLU MET          
SEQRES   2 A  587  ARG TYR LEU ARG GLU ALA GLY LYS ALA PHE ALA GLN ALA          
SEQRES   3 A  587  HIS PRO ASP ARG ALA ALA MET LEU ASP LEU ASP LYS ALA          
SEQRES   4 A  587  GLY THR PRO ASP PRO CYS VAL GLU ARG LEU PHE GLU GLY          
SEQRES   5 A  587  PHE ALA PHE SER MET GLY ARG LEU ARG GLN LYS ILE ASP          
SEQRES   6 A  587  ASP ASP LEU PRO GLU LEU THR GLU SER LEU VAL SER MET          
SEQRES   7 A  587  LEU TRP PRO HIS TYR LEU ARG THR ILE PRO SER LEU SER          
SEQRES   8 A  587  VAL VAL ALA LEU THR PRO ARG LEU SER VAL MET LYS MET          
SEQRES   9 A  587  ALA GLU THR VAL PRO ALA GLY LEU GLU VAL THR SER ARG          
SEQRES  10 A  587  PRO VAL GLY PRO GLY ASN THR VAL CYS ARG TYR ARG THR          
SEQRES  11 A  587  THR ARG ALA ILE PRO LEU ASN PRO LEU ALA VAL GLU LYS          
SEQRES  12 A  587  VAL VAL MET THR THR GLU PRO ASP GLY ARG SER VAL LEU          
SEQRES  13 A  587  LYS ILE GLY PHE ALA CYS SER GLU LEU ALA ASP TRP SER          
SEQRES  14 A  587  GLN VAL ASP LEU HIS ARG LEU SER LEU TYR LEU ALA ALA          
SEQRES  15 A  587  GLU ALA PRO VAL SER SER THR LEU HIS LEU MET MET THR          
SEQRES  16 A  587  LYS ARG LEU ALA ALA LEU TYR LEU ARG LEU PRO GLY ASN          
SEQRES  17 A  587  ASP GLU ARG ILE ARG ILE ASP GLY TRP PHE SER PRO GLY          
SEQRES  18 A  587  GLY PHE ALA GLU GLU ASP ARG LEU TRP PRO LYS GLY ASP          
SEQRES  19 A  587  SER ALA PHE SER GLY TYR GLN LEU LEU LEU GLU TYR PHE          
SEQRES  20 A  587  THR PHE ARG GLU LYS PHE MET PHE VAL HIS LEU ASN GLY          
SEQRES  21 A  587  LEU GLU ASN VAL SER LEU PRO ALA GLY ILE SER GLY PHE          
SEQRES  22 A  587  ASP LEU GLU VAL VAL LEU SER GLN PRO TRP PRO ALA ASP          
SEQRES  23 A  587  LEU PRO VAL THR ASP ASP ALA LEU CYS LEU HIS CYS VAL          
SEQRES  24 A  587  PRO VAL ILE ASN LEU PHE THR LEU GLU ALA ASP PRO LEU          
SEQRES  25 A  587  ILE ILE ASN GLY LEU GLU SER GLU TYR LEU LEU ARG PRO          
SEQRES  26 A  587  LYS ARG LEU GLN ASP GLY TYR THR GLU ILE TYR SER VAL          
SEQRES  27 A  587  ASP ALA VAL THR GLY SER GLY ARG THR GLY SER ALA GLU          
SEQRES  28 A  587  TYR VAL PRO PHE THR SER PHE ARG HIS ARG GLY GLY MET          
SEQRES  29 A  587  LEU ARG HIS ASP ALA PRO GLU ARG TYR TYR HIS THR ARG          
SEQRES  30 A  587  VAL LYS ARG GLY VAL THR GLY MET TYR ASP THR TRP LEU          
SEQRES  31 A  587  ILE LEU GLY GLY GLN ARG TRP GLU ALA ASP ARG MET PRO          
SEQRES  32 A  587  GLU ARG GLU THR LEU SER LEU ARG ILE THR GLY THR ASN          
SEQRES  33 A  587  GLY GLN LEU PRO ARG ARG ALA LEU GLN SER THR LEU LEU          
SEQRES  34 A  587  ASP ARG CYS GLU GLN VAL LEU GLN ALA PRO VAL SER VAL          
SEQRES  35 A  587  ARG ASN LEU CYS LYS PRO THR LEU PRO VAL TYR PRO PRO          
SEQRES  36 A  587  THR GLU ASP ARG PHE HIS TRP ARG VAL MET SER HIS LEU          
SEQRES  37 A  587  GLY THR GLY PHE LEU ASN MET LEU SER SER ALA GLU VAL          
SEQRES  38 A  587  LEU ARG GLY THR LEU ALA LEU TYR ASN TRP ARG ASP ASP          
SEQRES  39 A  587  GLU LEU ASN HIS ARG ARG LEU ASP ALA ILE LEU ALA VAL          
SEQRES  40 A  587  GLN HIS HIS ARG ILE GLN ARG PHE GLU LYS GLY PHE LEU          
SEQRES  41 A  587  LEU ARG GLY LEU ASP VAL GLU VAL THR LEU ASP GLY ASN          
SEQRES  42 A  587  GLY PHE ALA GLY GLU GLY ASP ILE HIS LEU PHE GLY GLU          
SEQRES  43 A  587  MET LEU ASN ARG PHE LEU ALA LEU TYR ALA ASP MET ASN          
SEQRES  44 A  587  GLN PHE ASN GLN LEU THR LEU ILE VAL GLN PRO GLU GLY          
SEQRES  45 A  587  LYS CYS ILE ARG TRP LYS GLU ASN HIS ASN PRO ARG LEU          
SEQRES  46 A  587  PRO GLY                                                      
SEQRES   1 B  587  MET ASP ASP LEU THR LEU ARG TYR PHE ASP ALA GLU MET          
SEQRES   2 B  587  ARG TYR LEU ARG GLU ALA GLY LYS ALA PHE ALA GLN ALA          
SEQRES   3 B  587  HIS PRO ASP ARG ALA ALA MET LEU ASP LEU ASP LYS ALA          
SEQRES   4 B  587  GLY THR PRO ASP PRO CYS VAL GLU ARG LEU PHE GLU GLY          
SEQRES   5 B  587  PHE ALA PHE SER MET GLY ARG LEU ARG GLN LYS ILE ASP          
SEQRES   6 B  587  ASP ASP LEU PRO GLU LEU THR GLU SER LEU VAL SER MET          
SEQRES   7 B  587  LEU TRP PRO HIS TYR LEU ARG THR ILE PRO SER LEU SER          
SEQRES   8 B  587  VAL VAL ALA LEU THR PRO ARG LEU SER VAL MET LYS MET          
SEQRES   9 B  587  ALA GLU THR VAL PRO ALA GLY LEU GLU VAL THR SER ARG          
SEQRES  10 B  587  PRO VAL GLY PRO GLY ASN THR VAL CYS ARG TYR ARG THR          
SEQRES  11 B  587  THR ARG ALA ILE PRO LEU ASN PRO LEU ALA VAL GLU LYS          
SEQRES  12 B  587  VAL VAL MET THR THR GLU PRO ASP GLY ARG SER VAL LEU          
SEQRES  13 B  587  LYS ILE GLY PHE ALA CYS SER GLU LEU ALA ASP TRP SER          
SEQRES  14 B  587  GLN VAL ASP LEU HIS ARG LEU SER LEU TYR LEU ALA ALA          
SEQRES  15 B  587  GLU ALA PRO VAL SER SER THR LEU HIS LEU MET MET THR          
SEQRES  16 B  587  LYS ARG LEU ALA ALA LEU TYR LEU ARG LEU PRO GLY ASN          
SEQRES  17 B  587  ASP GLU ARG ILE ARG ILE ASP GLY TRP PHE SER PRO GLY          
SEQRES  18 B  587  GLY PHE ALA GLU GLU ASP ARG LEU TRP PRO LYS GLY ASP          
SEQRES  19 B  587  SER ALA PHE SER GLY TYR GLN LEU LEU LEU GLU TYR PHE          
SEQRES  20 B  587  THR PHE ARG GLU LYS PHE MET PHE VAL HIS LEU ASN GLY          
SEQRES  21 B  587  LEU GLU ASN VAL SER LEU PRO ALA GLY ILE SER GLY PHE          
SEQRES  22 B  587  ASP LEU GLU VAL VAL LEU SER GLN PRO TRP PRO ALA ASP          
SEQRES  23 B  587  LEU PRO VAL THR ASP ASP ALA LEU CYS LEU HIS CYS VAL          
SEQRES  24 B  587  PRO VAL ILE ASN LEU PHE THR LEU GLU ALA ASP PRO LEU          
SEQRES  25 B  587  ILE ILE ASN GLY LEU GLU SER GLU TYR LEU LEU ARG PRO          
SEQRES  26 B  587  LYS ARG LEU GLN ASP GLY TYR THR GLU ILE TYR SER VAL          
SEQRES  27 B  587  ASP ALA VAL THR GLY SER GLY ARG THR GLY SER ALA GLU          
SEQRES  28 B  587  TYR VAL PRO PHE THR SER PHE ARG HIS ARG GLY GLY MET          
SEQRES  29 B  587  LEU ARG HIS ASP ALA PRO GLU ARG TYR TYR HIS THR ARG          
SEQRES  30 B  587  VAL LYS ARG GLY VAL THR GLY MET TYR ASP THR TRP LEU          
SEQRES  31 B  587  ILE LEU GLY GLY GLN ARG TRP GLU ALA ASP ARG MET PRO          
SEQRES  32 B  587  GLU ARG GLU THR LEU SER LEU ARG ILE THR GLY THR ASN          
SEQRES  33 B  587  GLY GLN LEU PRO ARG ARG ALA LEU GLN SER THR LEU LEU          
SEQRES  34 B  587  ASP ARG CYS GLU GLN VAL LEU GLN ALA PRO VAL SER VAL          
SEQRES  35 B  587  ARG ASN LEU CYS LYS PRO THR LEU PRO VAL TYR PRO PRO          
SEQRES  36 B  587  THR GLU ASP ARG PHE HIS TRP ARG VAL MET SER HIS LEU          
SEQRES  37 B  587  GLY THR GLY PHE LEU ASN MET LEU SER SER ALA GLU VAL          
SEQRES  38 B  587  LEU ARG GLY THR LEU ALA LEU TYR ASN TRP ARG ASP ASP          
SEQRES  39 B  587  GLU LEU ASN HIS ARG ARG LEU ASP ALA ILE LEU ALA VAL          
SEQRES  40 B  587  GLN HIS HIS ARG ILE GLN ARG PHE GLU LYS GLY PHE LEU          
SEQRES  41 B  587  LEU ARG GLY LEU ASP VAL GLU VAL THR LEU ASP GLY ASN          
SEQRES  42 B  587  GLY PHE ALA GLY GLU GLY ASP ILE HIS LEU PHE GLY GLU          
SEQRES  43 B  587  MET LEU ASN ARG PHE LEU ALA LEU TYR ALA ASP MET ASN          
SEQRES  44 B  587  GLN PHE ASN GLN LEU THR LEU ILE VAL GLN PRO GLU GLY          
SEQRES  45 B  587  LYS CYS ILE ARG TRP LYS GLU ASN HIS ASN PRO ARG LEU          
SEQRES  46 B  587  PRO GLY                                                      
SEQRES   1 C  366  MET HIS PRO VAL GLU ARG LYS SER GLN SER ALA PRO ALA          
SEQRES   2 C  366  ARG LEU ILE THR ARG TYR ARG LYS GLN LEU PRO TYR ILE          
SEQRES   3 C  366  ASN PHE TYR ARG PHE CYS GLN LEU LEU GLU GLN SER GLN          
SEQRES   4 C  366  PRO ASP GLN PRO PRO ILE GLY SER GLY TRP GLN ALA ARG          
SEQRES   5 C  366  GLN GLU ALA VAL ARG PHE CYS PRO TYR PRO GLY MET GLY          
SEQRES   6 C  366  PHE PRO ALA SER GLU ILE LYS ASP ALA VAL ILE PRO GLU          
SEQRES   7 C  366  GLU SER HIS LEU PRO PRO ILE VAL HIS VAL THR PHE MET          
SEQRES   8 C  366  GLY LEU TYR GLY VAL THR SER PRO LEU PRO ALA HIS TYR          
SEQRES   9 C  366  ILE SER ASP ILE ALA GLN GLN ARG GLU GLY HIS GLU ALA          
SEQRES  10 C  366  ALA ALA ASP PHE LEU ASP ILE PHE SER HIS ARG LEU ILE          
SEQRES  11 C  366  THR GLN TYR TYR ARG ILE TRP ARG LYS TYR SER TYR PRO          
SEQRES  12 C  366  ALA THR PHE GLU ALA GLY GLY GLN ASP LYS THR SER GLN          
SEQRES  13 C  366  TYR LEU LEU GLY LEU ALA ARG LEU GLY ILE PRO GLY CYS          
SEQRES  14 C  366  ALA GLN ASN ILE ALA THR PRO VAL SER ARG PHE LEU ALA          
SEQRES  15 C  366  LEU LEU PRO LEU MET LEU LEU PRO GLY ARG THR ALA GLU          
SEQRES  16 C  366  GLY LEU THR SER LEU VAL THR LEU LEU ALA PRO GLY THR          
SEQRES  17 C  366  GLN ALA ARG VAL TRP HIS HIS ASP ARG ARG ARG ILE PRO          
SEQRES  18 C  366  LEU LYS THR PRO LEU THR MET ARG VAL HIS HIS PRO VAL          
SEQRES  19 C  366  SER LEU LYS SER ARG PRO VAL MET GLY ASP HIS ALA THR          
SEQRES  20 C  366  ASP VAL ASN GLY GLN VAL LEU LEU GLN LEU SER THR GLN          
SEQRES  21 C  366  THR GLY SER GLU VAL GLN GLY TRP LEU PRO GLY GLY HIS          
SEQRES  22 C  366  LEU TYR SER ASP LEU LEU ALA LEU LEU HIS VAL TYR LEU          
SEQRES  23 C  366  GLY SER ARG LEU ASP VAL ARG LEU GLN LEU CYS VAL GLU          
SEQRES  24 C  366  ARG SER LEU LEU PRO ASP ALA ARG LEU SER CYS ARG PRO          
SEQRES  25 C  366  ALA ALA GLY SER PRO GLN LEU GLY ARG THR ALA VAL MET          
SEQRES  26 C  366  ARG THR GLN ALA LYS ILE ALA THR SER ALA ALA ARG VAL          
SEQRES  27 C  366  MET THR ILE SER LEU GLY ARG TYR GLN ARG VAL GLN GLU          
SEQRES  28 C  366  HIS TYR GLN ARG LYS GLU THR GLN GLU ASN GLY ASP TYR          
SEQRES  29 C  366  ARG TRP                                                      
SEQRES   1 D  444  MET LYS ILE TYR ARG PRO LEU TRP GLU ASP GLY ALA PHE          
SEQRES   2 D  444  LEU MET PRO GLN GLN PHE GLN GLN GLN ALA ALA TRP ASP          
SEQRES   3 D  444  VAL HIS LEU ALA ASP SER VAL ALA ARG MET GLY LEU ALA          
SEQRES   4 D  444  HIS PRO TRP GLY VAL VAL ALA ALA GLU PHE ASP ASP SER          
SEQRES   5 D  444  LEU LEU PRO LEU SER ARG LEU ASN ALA THR ARG LEU ILE          
SEQRES   6 D  444  VAL ARG PHE PRO ASP GLY THR LEU ILE ASP THR GLU ARG          
SEQRES   7 D  444  ALA ASP ASN LEU PRO PRO VAL CYS ASP LEU SER THR VAL          
SEQRES   8 D  444  SER ASP ARG SER LEU VAL ASP ILE VAL LEU ALA LEU PRO          
SEQRES   9 D  444  LEU LEU ASN ALA ASN GLY GLY ASN LEU ASP ASN GLY SER          
SEQRES  10 D  444  GLU SER GLU ARG PRO ARG ARG TRP LYS SER GLU ARG VAL          
SEQRES  11 D  444  ASN VAL GLN GLU LEU ALA GLY HIS GLU GLN SER GLU VAL          
SEQRES  12 D  444  ALA VAL LEU ARG HIS ASN LEU THR LEU ARG MET ALA HIS          
SEQRES  13 D  444  GLN GLU ASN ALA ALA TRP LEU THR CYS PRO VAL THR ARG          
SEQRES  14 D  444  LEU VAL ARG ASP ALA GLN GLY GLN TRP CYS ARG ASP PRO          
SEQRES  15 D  444  ARG PHE ILE PRO PRO LEU LEU THR LEU SER ALA SER PRO          
SEQRES  16 D  444  SER LEU MET THR GLU LEU LEU GLU LEU LEU HIS HIS LEU          
SEQRES  17 D  444  GLN ALA ARG ARG GLN ARG LEU MET SER MET ARG ARG GLU          
SEQRES  18 D  444  ASN ASN ALA ARG LEU ALA ASP PHE ALA VAL ALA ASP VAL          
SEQRES  19 D  444  SER LEU PHE TRP LEU LEU ASN ALA LEU ASN SER ALA GLU          
SEQRES  20 D  444  PRO VAL LEU LYS GLU LEU LEU ASP MET PRO TYR ARG HIS          
SEQRES  21 D  444  PRO GLU LEU LEU TYR ARG GLU LEU ALA ARG LEU ALA GLY          
SEQRES  22 D  444  SER LEU LEU THR PHE SER LEU GLU HIS ASN VAL ASP ALA          
SEQRES  23 D  444  VAL PRO ALA TYR HIS HIS GLU THR PRO GLU ASN VAL PHE          
SEQRES  24 D  444  PRO PRO LEU LEU SER LEU LEU ASN ARG LEU LEU GLU ALA          
SEQRES  25 D  444  SER LEU PRO SER ARG VAL VAL PHE ILE GLU LEU LYS GLN          
SEQRES  26 D  444  LYS GLY VAL MET TRP GLU GLY ALA LEU HIS ASP ALA ARG          
SEQRES  27 D  444  LEU ARG GLU GLY ALA ASP PHE TRP LEU SER VAL ARG SER          
SEQRES  28 D  444  SER MET PRO GLY HIS GLU LEU GLN THR LYS PHE PRO GLN          
SEQRES  29 D  444  LEU CYS LYS ALA GLY SER PRO ASP ASP VAL SER GLU VAL          
SEQRES  30 D  444  VAL ASN VAL ALA LEU SER GLY VAL ILE ILE ARG PRO VAL          
SEQRES  31 D  444  THR HIS VAL PRO ALA ALA ILE PRO LEU ARG LEU GLU ASN          
SEQRES  32 D  444  GLN TYR PHE ALA LEU ASP LEU SER THR ASP ALA ALA ARG          
SEQRES  33 D  444  ALA MET LEU ASP ALA GLY ARG CYS THR PHE TYR THR PRO          
SEQRES  34 D  444  ALA SER LEU GLY ASP VAL LYS LEU GLU LEU PHE ALA VAL          
SEQRES  35 D  444  LEU ARG                                                      
SEQRES   1 E  444  MET LYS ILE TYR ARG PRO LEU TRP GLU ASP GLY ALA PHE          
SEQRES   2 E  444  LEU MET PRO GLN GLN PHE GLN GLN GLN ALA ALA TRP ASP          
SEQRES   3 E  444  VAL HIS LEU ALA ASP SER VAL ALA ARG MET GLY LEU ALA          
SEQRES   4 E  444  HIS PRO TRP GLY VAL VAL ALA ALA GLU PHE ASP ASP SER          
SEQRES   5 E  444  LEU LEU PRO LEU SER ARG LEU ASN ALA THR ARG LEU ILE          
SEQRES   6 E  444  VAL ARG PHE PRO ASP GLY THR LEU ILE ASP THR GLU ARG          
SEQRES   7 E  444  ALA ASP ASN LEU PRO PRO VAL CYS ASP LEU SER THR VAL          
SEQRES   8 E  444  SER ASP ARG SER LEU VAL ASP ILE VAL LEU ALA LEU PRO          
SEQRES   9 E  444  LEU LEU ASN ALA ASN GLY GLY ASN LEU ASP ASN GLY SER          
SEQRES  10 E  444  GLU SER GLU ARG PRO ARG ARG TRP LYS SER GLU ARG VAL          
SEQRES  11 E  444  ASN VAL GLN GLU LEU ALA GLY HIS GLU GLN SER GLU VAL          
SEQRES  12 E  444  ALA VAL LEU ARG HIS ASN LEU THR LEU ARG MET ALA HIS          
SEQRES  13 E  444  GLN GLU ASN ALA ALA TRP LEU THR CYS PRO VAL THR ARG          
SEQRES  14 E  444  LEU VAL ARG ASP ALA GLN GLY GLN TRP CYS ARG ASP PRO          
SEQRES  15 E  444  ARG PHE ILE PRO PRO LEU LEU THR LEU SER ALA SER PRO          
SEQRES  16 E  444  SER LEU MET THR GLU LEU LEU GLU LEU LEU HIS HIS LEU          
SEQRES  17 E  444  GLN ALA ARG ARG GLN ARG LEU MET SER MET ARG ARG GLU          
SEQRES  18 E  444  ASN ASN ALA ARG LEU ALA ASP PHE ALA VAL ALA ASP VAL          
SEQRES  19 E  444  SER LEU PHE TRP LEU LEU ASN ALA LEU ASN SER ALA GLU          
SEQRES  20 E  444  PRO VAL LEU LYS GLU LEU LEU ASP MET PRO TYR ARG HIS          
SEQRES  21 E  444  PRO GLU LEU LEU TYR ARG GLU LEU ALA ARG LEU ALA GLY          
SEQRES  22 E  444  SER LEU LEU THR PHE SER LEU GLU HIS ASN VAL ASP ALA          
SEQRES  23 E  444  VAL PRO ALA TYR HIS HIS GLU THR PRO GLU ASN VAL PHE          
SEQRES  24 E  444  PRO PRO LEU LEU SER LEU LEU ASN ARG LEU LEU GLU ALA          
SEQRES  25 E  444  SER LEU PRO SER ARG VAL VAL PHE ILE GLU LEU LYS GLN          
SEQRES  26 E  444  LYS GLY VAL MET TRP GLU GLY ALA LEU HIS ASP ALA ARG          
SEQRES  27 E  444  LEU ARG GLU GLY ALA ASP PHE TRP LEU SER VAL ARG SER          
SEQRES  28 E  444  SER MET PRO GLY HIS GLU LEU GLN THR LYS PHE PRO GLN          
SEQRES  29 E  444  LEU CYS LYS ALA GLY SER PRO ASP ASP VAL SER GLU VAL          
SEQRES  30 E  444  VAL ASN VAL ALA LEU SER GLY VAL ILE ILE ARG PRO VAL          
SEQRES  31 E  444  THR HIS VAL PRO ALA ALA ILE PRO LEU ARG LEU GLU ASN          
SEQRES  32 E  444  GLN TYR PHE ALA LEU ASP LEU SER THR ASP ALA ALA ARG          
SEQRES  33 E  444  ALA MET LEU ASP ALA GLY ARG CYS THR PHE TYR THR PRO          
SEQRES  34 E  444  ALA SER LEU GLY ASP VAL LYS LEU GLU LEU PHE ALA VAL          
SEQRES  35 E  444  LEU ARG                                                      
SEQRES   1 F  444  MET LYS ILE TYR ARG PRO LEU TRP GLU ASP GLY ALA PHE          
SEQRES   2 F  444  LEU MET PRO GLN GLN PHE GLN GLN GLN ALA ALA TRP ASP          
SEQRES   3 F  444  VAL HIS LEU ALA ASP SER VAL ALA ARG MET GLY LEU ALA          
SEQRES   4 F  444  HIS PRO TRP GLY VAL VAL ALA ALA GLU PHE ASP ASP SER          
SEQRES   5 F  444  LEU LEU PRO LEU SER ARG LEU ASN ALA THR ARG LEU ILE          
SEQRES   6 F  444  VAL ARG PHE PRO ASP GLY THR LEU ILE ASP THR GLU ARG          
SEQRES   7 F  444  ALA ASP ASN LEU PRO PRO VAL CYS ASP LEU SER THR VAL          
SEQRES   8 F  444  SER ASP ARG SER LEU VAL ASP ILE VAL LEU ALA LEU PRO          
SEQRES   9 F  444  LEU LEU ASN ALA ASN GLY GLY ASN LEU ASP ASN GLY SER          
SEQRES  10 F  444  GLU SER GLU ARG PRO ARG ARG TRP LYS SER GLU ARG VAL          
SEQRES  11 F  444  ASN VAL GLN GLU LEU ALA GLY HIS GLU GLN SER GLU VAL          
SEQRES  12 F  444  ALA VAL LEU ARG HIS ASN LEU THR LEU ARG MET ALA HIS          
SEQRES  13 F  444  GLN GLU ASN ALA ALA TRP LEU THR CYS PRO VAL THR ARG          
SEQRES  14 F  444  LEU VAL ARG ASP ALA GLN GLY GLN TRP CYS ARG ASP PRO          
SEQRES  15 F  444  ARG PHE ILE PRO PRO LEU LEU THR LEU SER ALA SER PRO          
SEQRES  16 F  444  SER LEU MET THR GLU LEU LEU GLU LEU LEU HIS HIS LEU          
SEQRES  17 F  444  GLN ALA ARG ARG GLN ARG LEU MET SER MET ARG ARG GLU          
SEQRES  18 F  444  ASN ASN ALA ARG LEU ALA ASP PHE ALA VAL ALA ASP VAL          
SEQRES  19 F  444  SER LEU PHE TRP LEU LEU ASN ALA LEU ASN SER ALA GLU          
SEQRES  20 F  444  PRO VAL LEU LYS GLU LEU LEU ASP MET PRO TYR ARG HIS          
SEQRES  21 F  444  PRO GLU LEU LEU TYR ARG GLU LEU ALA ARG LEU ALA GLY          
SEQRES  22 F  444  SER LEU LEU THR PHE SER LEU GLU HIS ASN VAL ASP ALA          
SEQRES  23 F  444  VAL PRO ALA TYR HIS HIS GLU THR PRO GLU ASN VAL PHE          
SEQRES  24 F  444  PRO PRO LEU LEU SER LEU LEU ASN ARG LEU LEU GLU ALA          
SEQRES  25 F  444  SER LEU PRO SER ARG VAL VAL PHE ILE GLU LEU LYS GLN          
SEQRES  26 F  444  LYS GLY VAL MET TRP GLU GLY ALA LEU HIS ASP ALA ARG          
SEQRES  27 F  444  LEU ARG GLU GLY ALA ASP PHE TRP LEU SER VAL ARG SER          
SEQRES  28 F  444  SER MET PRO GLY HIS GLU LEU GLN THR LYS PHE PRO GLN          
SEQRES  29 F  444  LEU CYS LYS ALA GLY SER PRO ASP ASP VAL SER GLU VAL          
SEQRES  30 F  444  VAL ASN VAL ALA LEU SER GLY VAL ILE ILE ARG PRO VAL          
SEQRES  31 F  444  THR HIS VAL PRO ALA ALA ILE PRO LEU ARG LEU GLU ASN          
SEQRES  32 F  444  GLN TYR PHE ALA LEU ASP LEU SER THR ASP ALA ALA ARG          
SEQRES  33 F  444  ALA MET LEU ASP ALA GLY ARG CYS THR PHE TYR THR PRO          
SEQRES  34 F  444  ALA SER LEU GLY ASP VAL LYS LEU GLU LEU PHE ALA VAL          
SEQRES  35 F  444  LEU ARG                                                      
SEQRES   1 G  444  MET LYS ILE TYR ARG PRO LEU TRP GLU ASP GLY ALA PHE          
SEQRES   2 G  444  LEU MET PRO GLN GLN PHE GLN GLN GLN ALA ALA TRP ASP          
SEQRES   3 G  444  VAL HIS LEU ALA ASP SER VAL ALA ARG MET GLY LEU ALA          
SEQRES   4 G  444  HIS PRO TRP GLY VAL VAL ALA ALA GLU PHE ASP ASP SER          
SEQRES   5 G  444  LEU LEU PRO LEU SER ARG LEU ASN ALA THR ARG LEU ILE          
SEQRES   6 G  444  VAL ARG PHE PRO ASP GLY THR LEU ILE ASP THR GLU ARG          
SEQRES   7 G  444  ALA ASP ASN LEU PRO PRO VAL CYS ASP LEU SER THR VAL          
SEQRES   8 G  444  SER ASP ARG SER LEU VAL ASP ILE VAL LEU ALA LEU PRO          
SEQRES   9 G  444  LEU LEU ASN ALA ASN GLY GLY ASN LEU ASP ASN GLY SER          
SEQRES  10 G  444  GLU SER GLU ARG PRO ARG ARG TRP LYS SER GLU ARG VAL          
SEQRES  11 G  444  ASN VAL GLN GLU LEU ALA GLY HIS GLU GLN SER GLU VAL          
SEQRES  12 G  444  ALA VAL LEU ARG HIS ASN LEU THR LEU ARG MET ALA HIS          
SEQRES  13 G  444  GLN GLU ASN ALA ALA TRP LEU THR CYS PRO VAL THR ARG          
SEQRES  14 G  444  LEU VAL ARG ASP ALA GLN GLY GLN TRP CYS ARG ASP PRO          
SEQRES  15 G  444  ARG PHE ILE PRO PRO LEU LEU THR LEU SER ALA SER PRO          
SEQRES  16 G  444  SER LEU MET THR GLU LEU LEU GLU LEU LEU HIS HIS LEU          
SEQRES  17 G  444  GLN ALA ARG ARG GLN ARG LEU MET SER MET ARG ARG GLU          
SEQRES  18 G  444  ASN ASN ALA ARG LEU ALA ASP PHE ALA VAL ALA ASP VAL          
SEQRES  19 G  444  SER LEU PHE TRP LEU LEU ASN ALA LEU ASN SER ALA GLU          
SEQRES  20 G  444  PRO VAL LEU LYS GLU LEU LEU ASP MET PRO TYR ARG HIS          
SEQRES  21 G  444  PRO GLU LEU LEU TYR ARG GLU LEU ALA ARG LEU ALA GLY          
SEQRES  22 G  444  SER LEU LEU THR PHE SER LEU GLU HIS ASN VAL ASP ALA          
SEQRES  23 G  444  VAL PRO ALA TYR HIS HIS GLU THR PRO GLU ASN VAL PHE          
SEQRES  24 G  444  PRO PRO LEU LEU SER LEU LEU ASN ARG LEU LEU GLU ALA          
SEQRES  25 G  444  SER LEU PRO SER ARG VAL VAL PHE ILE GLU LEU LYS GLN          
SEQRES  26 G  444  LYS GLY VAL MET TRP GLU GLY ALA LEU HIS ASP ALA ARG          
SEQRES  27 G  444  LEU ARG GLU GLY ALA ASP PHE TRP LEU SER VAL ARG SER          
SEQRES  28 G  444  SER MET PRO GLY HIS GLU LEU GLN THR LYS PHE PRO GLN          
SEQRES  29 G  444  LEU CYS LYS ALA GLY SER PRO ASP ASP VAL SER GLU VAL          
SEQRES  30 G  444  VAL ASN VAL ALA LEU SER GLY VAL ILE ILE ARG PRO VAL          
SEQRES  31 G  444  THR HIS VAL PRO ALA ALA ILE PRO LEU ARG LEU GLU ASN          
SEQRES  32 G  444  GLN TYR PHE ALA LEU ASP LEU SER THR ASP ALA ALA ARG          
SEQRES  33 G  444  ALA MET LEU ASP ALA GLY ARG CYS THR PHE TYR THR PRO          
SEQRES  34 G  444  ALA SER LEU GLY ASP VAL LYS LEU GLU LEU PHE ALA VAL          
SEQRES  35 G  444  LEU ARG                                                      
SEQRES   1 H  444  MET LYS ILE TYR ARG PRO LEU TRP GLU ASP GLY ALA PHE          
SEQRES   2 H  444  LEU MET PRO GLN GLN PHE GLN GLN GLN ALA ALA TRP ASP          
SEQRES   3 H  444  VAL HIS LEU ALA ASP SER VAL ALA ARG MET GLY LEU ALA          
SEQRES   4 H  444  HIS PRO TRP GLY VAL VAL ALA ALA GLU PHE ASP ASP SER          
SEQRES   5 H  444  LEU LEU PRO LEU SER ARG LEU ASN ALA THR ARG LEU ILE          
SEQRES   6 H  444  VAL ARG PHE PRO ASP GLY THR LEU ILE ASP THR GLU ARG          
SEQRES   7 H  444  ALA ASP ASN LEU PRO PRO VAL CYS ASP LEU SER THR VAL          
SEQRES   8 H  444  SER ASP ARG SER LEU VAL ASP ILE VAL LEU ALA LEU PRO          
SEQRES   9 H  444  LEU LEU ASN ALA ASN GLY GLY ASN LEU ASP ASN GLY SER          
SEQRES  10 H  444  GLU SER GLU ARG PRO ARG ARG TRP LYS SER GLU ARG VAL          
SEQRES  11 H  444  ASN VAL GLN GLU LEU ALA GLY HIS GLU GLN SER GLU VAL          
SEQRES  12 H  444  ALA VAL LEU ARG HIS ASN LEU THR LEU ARG MET ALA HIS          
SEQRES  13 H  444  GLN GLU ASN ALA ALA TRP LEU THR CYS PRO VAL THR ARG          
SEQRES  14 H  444  LEU VAL ARG ASP ALA GLN GLY GLN TRP CYS ARG ASP PRO          
SEQRES  15 H  444  ARG PHE ILE PRO PRO LEU LEU THR LEU SER ALA SER PRO          
SEQRES  16 H  444  SER LEU MET THR GLU LEU LEU GLU LEU LEU HIS HIS LEU          
SEQRES  17 H  444  GLN ALA ARG ARG GLN ARG LEU MET SER MET ARG ARG GLU          
SEQRES  18 H  444  ASN ASN ALA ARG LEU ALA ASP PHE ALA VAL ALA ASP VAL          
SEQRES  19 H  444  SER LEU PHE TRP LEU LEU ASN ALA LEU ASN SER ALA GLU          
SEQRES  20 H  444  PRO VAL LEU LYS GLU LEU LEU ASP MET PRO TYR ARG HIS          
SEQRES  21 H  444  PRO GLU LEU LEU TYR ARG GLU LEU ALA ARG LEU ALA GLY          
SEQRES  22 H  444  SER LEU LEU THR PHE SER LEU GLU HIS ASN VAL ASP ALA          
SEQRES  23 H  444  VAL PRO ALA TYR HIS HIS GLU THR PRO GLU ASN VAL PHE          
SEQRES  24 H  444  PRO PRO LEU LEU SER LEU LEU ASN ARG LEU LEU GLU ALA          
SEQRES  25 H  444  SER LEU PRO SER ARG VAL VAL PHE ILE GLU LEU LYS GLN          
SEQRES  26 H  444  LYS GLY VAL MET TRP GLU GLY ALA LEU HIS ASP ALA ARG          
SEQRES  27 H  444  LEU ARG GLU GLY ALA ASP PHE TRP LEU SER VAL ARG SER          
SEQRES  28 H  444  SER MET PRO GLY HIS GLU LEU GLN THR LYS PHE PRO GLN          
SEQRES  29 H  444  LEU CYS LYS ALA GLY SER PRO ASP ASP VAL SER GLU VAL          
SEQRES  30 H  444  VAL ASN VAL ALA LEU SER GLY VAL ILE ILE ARG PRO VAL          
SEQRES  31 H  444  THR HIS VAL PRO ALA ALA ILE PRO LEU ARG LEU GLU ASN          
SEQRES  32 H  444  GLN TYR PHE ALA LEU ASP LEU SER THR ASP ALA ALA ARG          
SEQRES  33 H  444  ALA MET LEU ASP ALA GLY ARG CYS THR PHE TYR THR PRO          
SEQRES  34 H  444  ALA SER LEU GLY ASP VAL LYS LEU GLU LEU PHE ALA VAL          
SEQRES  35 H  444  LEU ARG                                                      
SEQRES   1 I  444  MET LYS ILE TYR ARG PRO LEU TRP GLU ASP GLY ALA PHE          
SEQRES   2 I  444  LEU MET PRO GLN GLN PHE GLN GLN GLN ALA ALA TRP ASP          
SEQRES   3 I  444  VAL HIS LEU ALA ASP SER VAL ALA ARG MET GLY LEU ALA          
SEQRES   4 I  444  HIS PRO TRP GLY VAL VAL ALA ALA GLU PHE ASP ASP SER          
SEQRES   5 I  444  LEU LEU PRO LEU SER ARG LEU ASN ALA THR ARG LEU ILE          
SEQRES   6 I  444  VAL ARG PHE PRO ASP GLY THR LEU ILE ASP THR GLU ARG          
SEQRES   7 I  444  ALA ASP ASN LEU PRO PRO VAL CYS ASP LEU SER THR VAL          
SEQRES   8 I  444  SER ASP ARG SER LEU VAL ASP ILE VAL LEU ALA LEU PRO          
SEQRES   9 I  444  LEU LEU ASN ALA ASN GLY GLY ASN LEU ASP ASN GLY SER          
SEQRES  10 I  444  GLU SER GLU ARG PRO ARG ARG TRP LYS SER GLU ARG VAL          
SEQRES  11 I  444  ASN VAL GLN GLU LEU ALA GLY HIS GLU GLN SER GLU VAL          
SEQRES  12 I  444  ALA VAL LEU ARG HIS ASN LEU THR LEU ARG MET ALA HIS          
SEQRES  13 I  444  GLN GLU ASN ALA ALA TRP LEU THR CYS PRO VAL THR ARG          
SEQRES  14 I  444  LEU VAL ARG ASP ALA GLN GLY GLN TRP CYS ARG ASP PRO          
SEQRES  15 I  444  ARG PHE ILE PRO PRO LEU LEU THR LEU SER ALA SER PRO          
SEQRES  16 I  444  SER LEU MET THR GLU LEU LEU GLU LEU LEU HIS HIS LEU          
SEQRES  17 I  444  GLN ALA ARG ARG GLN ARG LEU MET SER MET ARG ARG GLU          
SEQRES  18 I  444  ASN ASN ALA ARG LEU ALA ASP PHE ALA VAL ALA ASP VAL          
SEQRES  19 I  444  SER LEU PHE TRP LEU LEU ASN ALA LEU ASN SER ALA GLU          
SEQRES  20 I  444  PRO VAL LEU LYS GLU LEU LEU ASP MET PRO TYR ARG HIS          
SEQRES  21 I  444  PRO GLU LEU LEU TYR ARG GLU LEU ALA ARG LEU ALA GLY          
SEQRES  22 I  444  SER LEU LEU THR PHE SER LEU GLU HIS ASN VAL ASP ALA          
SEQRES  23 I  444  VAL PRO ALA TYR HIS HIS GLU THR PRO GLU ASN VAL PHE          
SEQRES  24 I  444  PRO PRO LEU LEU SER LEU LEU ASN ARG LEU LEU GLU ALA          
SEQRES  25 I  444  SER LEU PRO SER ARG VAL VAL PHE ILE GLU LEU LYS GLN          
SEQRES  26 I  444  LYS GLY VAL MET TRP GLU GLY ALA LEU HIS ASP ALA ARG          
SEQRES  27 I  444  LEU ARG GLU GLY ALA ASP PHE TRP LEU SER VAL ARG SER          
SEQRES  28 I  444  SER MET PRO GLY HIS GLU LEU GLN THR LYS PHE PRO GLN          
SEQRES  29 I  444  LEU CYS LYS ALA GLY SER PRO ASP ASP VAL SER GLU VAL          
SEQRES  30 I  444  VAL ASN VAL ALA LEU SER GLY VAL ILE ILE ARG PRO VAL          
SEQRES  31 I  444  THR HIS VAL PRO ALA ALA ILE PRO LEU ARG LEU GLU ASN          
SEQRES  32 I  444  GLN TYR PHE ALA LEU ASP LEU SER THR ASP ALA ALA ARG          
SEQRES  33 I  444  ALA MET LEU ASP ALA GLY ARG CYS THR PHE TYR THR PRO          
SEQRES  34 I  444  ALA SER LEU GLY ASP VAL LYS LEU GLU LEU PHE ALA VAL          
SEQRES  35 I  444  LEU ARG                                                      
HELIX    1 AA1 THR A    5  LYS A   21  1                                  17    
HELIX    2 AA2 VAL A   46  GLU A   51  1                                   6    
HELIX    3 AA3 PHE A   55  ASP A   66  1                                  12    
HELIX    4 AA4 LEU A   68  SER A   77  1                                  10    
HELIX    5 AA5 GLU A  164  LEU A  173  1                                  10    
HELIX    6 AA6 GLU A  183  THR A  195  1                                  13    
HELIX    7 AA7 LEU A  229  ASP A  234  1                                   6    
HELIX    8 AA8 PRO A  354  PHE A  358  5                                   5    
HELIX    9 AA9 ASP A  430  VAL A  435  5                                   6    
HELIX   10 AB1 HIS A  461  SER A  466  1                                   6    
HELIX   11 AB2 SER A  466  GLY A  471  1                                   6    
HELIX   12 AB3 SER A  478  THR A  485  1                                   8    
HELIX   13 AB4 ASP A  494  ARG A  500  1                                   7    
HELIX   14 AB5 GLU A  538  ALA A  553  1                                  16    
HELIX   15 AB6 THR B    5  HIS B   27  1                                  23    
HELIX   16 AB7 PRO B   28  ALA B   32  5                                   5    
HELIX   17 AB8 MET B   33  LYS B   38  1                                   6    
HELIX   18 AB9 VAL B   46  LEU B   68  1                                  23    
HELIX   19 AC1 GLU B   70  LEU B   79  5                                  10    
HELIX   20 AC2 PRO B   81  THR B   86  5                                   6    
HELIX   21 AC3 ASP B  167  VAL B  171  5                                   5    
HELIX   22 AC4 SER B  188  LYS B  196  1                                   9    
HELIX   23 AC5 ARG B  197  ALA B  199  5                                   3    
HELIX   24 AC6 GLY B  222  GLU B  226  5                                   5    
HELIX   25 AC7 LEU B  229  ALA B  236  1                                   8    
HELIX   26 AC8 LEU B  275  SER B  280  1                                   6    
HELIX   27 AC9 ARG B  324  GLN B  329  1                                   6    
HELIX   28 AD1 GLN B  329  GLU B  334  1                                   6    
HELIX   29 AD2 THR B  356  ARG B  361  1                                   6    
HELIX   30 AD3 ARG B  396  ARG B  401  5                                   6    
HELIX   31 AD4 ARG B  459  VAL B  464  1                                   6    
HELIX   32 AD5 VAL B  464  GLY B  469  1                                   6    
HELIX   33 AD6 SER B  477  ARG B  483  1                                   7    
HELIX   34 AD7 LEU B  486  ASN B  490  5                                   5    
HELIX   35 AD8 ASP B  494  ASP B  502  1                                   9    
HELIX   36 AD9 GLY B  537  PHE B  551  1                                  15    
HELIX   37 AE1 GLN C    9  LEU C   15  1                                   7    
HELIX   38 AE2 GLN C   22  ILE C   26  5                                   5    
HELIX   39 AE3 ASN C   27  GLN C   39  1                                  13    
HELIX   40 AE4 ILE C   45  ALA C   51  5                                   7    
HELIX   41 AE5 PRO C  101  ALA C  109  1                                   9    
HELIX   42 AE6 ARG C  112  ALA C  117  5                                   6    
HELIX   43 AE7 ALA C  118  ASP C  123  1                                   6    
HELIX   44 AE8 ASP C  123  LYS C  139  1                                  17    
HELIX   45 AE9 THR C  154  GLY C  160  1                                   7    
HELIX   46 AF1 ARG C  179  MET C  187  1                                   9    
HELIX   47 AF2 GLU C  195  ALA C  205  1                                  11    
HELIX   48 AF3 THR C  261  LEU C  269  1                                   9    
HELIX   49 AF4 HIS C  273  HIS C  283  1                                  11    
HELIX   50 AF5 MET D   15  ARG D   35  1                                  21    
HELIX   51 AF6 SER D  194  MET D  218  1                                  25    
HELIX   52 AF7 ARG D  225  ALA D  230  1                                   6    
HELIX   53 AF8 SER D  235  SER D  245  1                                  11    
HELIX   54 AF9 ALA D  246  LEU D  254  1                                   9    
HELIX   55 AG1 HIS D  260  LEU D  275  1                                  16    
HELIX   56 AG2 THR D  294  ASN D  297  5                                   4    
HELIX   57 AG3 VAL D  298  GLU D  311  1                                  14    
HELIX   58 AG4 MET E   15  SER E   32  1                                  18    
HELIX   59 AG5 THR E  190  ALA E  193  5                                   4    
HELIX   60 AG6 SER E  194  MET E  218  1                                  25    
HELIX   61 AG7 ARG E  219  ASN E  222  5                                   4    
HELIX   62 AG8 ALA E  232  ALA E  242  1                                  11    
HELIX   63 AG9 ALA E  246  GLU E  252  1                                   7    
HELIX   64 AH1 PRO E  261  THR E  277  1                                  17    
HELIX   65 AH2 THR E  294  ASN E  297  5                                   4    
HELIX   66 AH3 VAL E  298  LEU E  310  1                                  13    
HELIX   67 AH4 MET F   15  VAL F   33  1                                  19    
HELIX   68 AH5 LEU F   53  SER F   57  5                                   5    
HELIX   69 AH6 SER F  194  ASN F  222  1                                  29    
HELIX   70 AH7 ALA F  230  SER F  245  1                                  16    
HELIX   71 AH8 ALA F  246  LEU F  253  1                                   8    
HELIX   72 AH9 HIS F  260  LEU F  275  1                                  16    
HELIX   73 AI1 LEU F  275  LEU F  280  1                                   6    
HELIX   74 AI2 THR F  294  ASN F  297  5                                   4    
HELIX   75 AI3 VAL F  298  LEU F  310  1                                  13    
HELIX   76 AI4 PRO G   16  MET G   36  1                                  21    
HELIX   77 AI5 GLN G  133  GLY G  137  5                                   5    
HELIX   78 AI6 SER G  194  MET G  218  1                                  25    
HELIX   79 AI7 MET G  218  ASN G  223  1                                   6    
HELIX   80 AI8 ALA G  230  SER G  245  1                                  16    
HELIX   81 AI9 ALA G  246  LEU G  253  1                                   8    
HELIX   82 AJ1 HIS G  260  GLY G  273  1                                  14    
HELIX   83 AJ2 THR G  294  ASN G  297  5                                   4    
HELIX   84 AJ3 VAL G  298  GLU G  311  1                                  14    
HELIX   85 AJ4 PRO G  354  CYS G  366  1                                  13    
HELIX   86 AJ5 SER G  411  LEU G  419  1                                   9    
HELIX   87 AJ6 MET H   15  ARG H   35  1                                  21    
HELIX   88 AJ7 LEU H   53  SER H   57  5                                   5    
HELIX   89 AJ8 SER H  194  ARG H  220  1                                  27    
HELIX   90 AJ9 SER H  235  LEU H  254  1                                  20    
HELIX   91 AK1 HIS H  260  LEU H  276  1                                  17    
HELIX   92 AK2 ASN H  283  VAL H  287  5                                   5    
HELIX   93 AK3 VAL H  298  LEU H  310  1                                  13    
HELIX   94 AK4 ASP H  336  GLU H  341  5                                   6    
HELIX   95 AK5 GLY H  355  GLN H  359  5                                   5    
HELIX   96 AK6 ASP H  413  GLY H  422  1                                  10    
HELIX   97 AK7 THR H  428  GLY H  433  5                                   6    
HELIX   98 AK8 MET I   15  ALA I   24  1                                  10    
HELIX   99 AK9 TRP I   25  ARG I   35  1                                  11    
HELIX  100 AL1 SER I   89  SER I   92  5                                   4    
HELIX  101 AL2 SER I  194  ARG I  220  1                                  27    
HELIX  102 AL3 ALA I  230  ASP I  255  1                                  26    
HELIX  103 AL4 HIS I  260  LEU I  276  1                                  17    
HELIX  104 AL5 ASN I  283  VAL I  287  5                                   5    
HELIX  105 AL6 VAL I  298  LEU I  310  1                                  13    
SHEET    1 AA1 3 PRO A 300  ILE A 302  0                                        
SHEET    2 AA1 3 LEU A  90  ALA A  94 -1  N  SER A  91   O  VAL A 301           
SHEET    3 AA1 3 ARG A 443  ASN A 444 -1  O  ARG A 443   N  ALA A  94           
SHEET    1 AA2 3 PHE A 305  LEU A 307  0                                        
SHEET    2 AA2 3 SER A 409  GLY A 414 -1  O  GLY A 414   N  PHE A 305           
SHEET    3 AA2 3 VAL A 338  THR A 342 -1  N  ASP A 339   O  ARG A 411           
SHEET    1 AA3 4 ILE A 504  HIS A 509  0                                        
SHEET    2 AA3 4 ASP A 525  THR A 529 -1  O  ASP A 525   N  HIS A 509           
SHEET    3 AA3 4 LEU A 564  ILE A 567  1  O  ILE A 567   N  VAL A 528           
SHEET    4 AA3 4 ILE A 575  ARG A 576 -1  O  ILE A 575   N  LEU A 566           
SHEET    1 AA4 2 ILE A 512  ARG A 514  0                                        
SHEET    2 AA4 2 LEU A 520  ARG A 522 -1  O  LEU A 521   N  GLN A 513           
SHEET    1 AA5 2 THR B 147  THR B 148  0                                        
SHEET    2 AA5 2 SER B 154  VAL B 155 -1  O  VAL B 155   N  THR B 147           
SHEET    1 AA6 2 LEU B 203  ARG B 204  0                                        
SHEET    2 AA6 2 GLY B 272  PHE B 273 -1  O  GLY B 272   N  ARG B 204           
SHEET    1 AA7 3 PHE B 305  LEU B 307  0                                        
SHEET    2 AA7 3 ARG B 411  ASN B 416 -1  O  GLY B 414   N  PHE B 305           
SHEET    3 AA7 3 TYR B 336  THR B 342 -1  N  SER B 337   O  THR B 415           
SHEET    1 AA8 2 TYR B 374  THR B 376  0                                        
SHEET    2 AA8 2 LEU B 392  GLY B 394 -1  O  GLY B 393   N  HIS B 375           
SHEET    1 AA9 2 LYS B 379  ARG B 380  0                                        
SHEET    2 AA9 2 THR B 388  TRP B 389 -1  O  TRP B 389   N  LYS B 379           
SHEET    1 AB1 2 GLN B 508  HIS B 510  0                                        
SHEET    2 AB1 2 GLY B 523  ASP B 525 -1  O  GLY B 523   N  HIS B 510           
SHEET    1 AB2 2 THR B 565  LEU B 566  0                                        
SHEET    2 AB2 2 CYS B 574  ILE B 575 -1  O  CYS B 574   N  LEU B 566           
SHEET    1 AB3 4 GLN C 209  TRP C 213  0                                        
SHEET    2 AB3 4 LEU C 254  SER C 258 -1  O  LEU C 254   N  TRP C 213           
SHEET    3 AB3 4 ARG C 293  GLU C 299  1  O  ARG C 293   N  LEU C 255           
SHEET    4 AB3 4 ILE C 331  ARG C 337 -1  O  SER C 334   N  LEU C 296           
SHEET    1 AB4 3 VAL D  44  ASP D  50  0                                        
SHEET    2 AB4 3 ASN D  60  ARG D  67 -1  O  ILE D  65   N  VAL D  45           
SHEET    3 AB4 3 LEU D  73  ASP D  75 -1  O  ILE D  74   N  VAL D  66           
SHEET    1 AB5 4 THR D 151  ARG D 153  0                                        
SHEET    2 AB5 4 VAL D  97  PRO D 104 -1  N  VAL D 100   O  ARG D 153           
SHEET    3 AB5 4 TRP D 162  ARG D 172 -1  O  LEU D 170   N  VAL D  97           
SHEET    4 AB5 4 TRP D 178  ARG D 180 -1  O  CYS D 179   N  VAL D 171           
SHEET    1 AB6 2 ARG D 124  GLN D 133  0                                        
SHEET    2 AB6 2 GLN D 140  HIS D 148 -1  O  ARG D 147   N  TRP D 125           
SHEET    1 AB7 3 VAL E  44  PHE E  49  0                                        
SHEET    2 AB7 3 ALA E  61  ARG E  67 -1  O  ILE E  65   N  ALA E  46           
SHEET    3 AB7 3 LEU E  73  ASP E  75 -1  O  ILE E  74   N  VAL E  66           
SHEET    1 AB8 3 THR E 151  MET E 154  0                                        
SHEET    2 AB8 3 VAL E  97  PRO E 104 -1  N  VAL E 100   O  ARG E 153           
SHEET    3 AB8 3 TRP E 162  LEU E 163 -1  O  LEU E 163   N  LEU E 103           
SHEET    1 AB9 4 THR E 151  MET E 154  0                                        
SHEET    2 AB9 4 VAL E  97  PRO E 104 -1  N  VAL E 100   O  ARG E 153           
SHEET    3 AB9 4 PRO E 166  ARG E 172 -1  O  VAL E 167   N  ILE E  99           
SHEET    4 AB9 4 TRP E 178  ARG E 180 -1  O  CYS E 179   N  VAL E 171           
SHEET    1 AC1 2 LYS E 126  GLN E 133  0                                        
SHEET    2 AC1 2 GLN E 140  ARG E 147 -1  O  VAL E 145   N  GLU E 128           
SHEET    1 AC2 3 VAL F  44  PHE F  49  0                                        
SHEET    2 AC2 3 ALA F  61  PHE F  68 -1  O  THR F  62   N  GLU F  48           
SHEET    3 AC2 3 THR F  72  ASP F  75 -1  O  ILE F  74   N  VAL F  66           
SHEET    1 AC3 2 GLU F 128  VAL F 132  0                                        
SHEET    2 AC3 2 SER F 141  VAL F 145 -1  O  SER F 141   N  VAL F 132           
SHEET    1 AC4 2 LEU F 170  ARG F 172  0                                        
SHEET    2 AC4 2 TRP F 178  ARG F 180 -1  O  CYS F 179   N  VAL F 171           
SHEET    1 AC5 3 VAL G  44  PHE G  49  0                                        
SHEET    2 AC5 3 ALA G  61  ARG G  67 -1  O  ILE G  65   N  ALA G  46           
SHEET    3 AC5 3 LEU G  73  ASP G  75 -1  O  ILE G  74   N  VAL G  66           
SHEET    1 AC6 2 ARG G  58  LEU G  59  0                                        
SHEET    2 AC6 2 CYS G  86  ASP G  87 -1  O  CYS G  86   N  LEU G  59           
SHEET    1 AC7 4 THR G 151  MET G 154  0                                        
SHEET    2 AC7 4 ASP G  98  ALA G 102 -1  N  VAL G 100   O  ARG G 153           
SHEET    3 AC7 4 CYS G 165  ARG G 172 -1  O  VAL G 167   N  ILE G  99           
SHEET    4 AC7 4 TRP G 178  ARG G 180 -1  O  CYS G 179   N  VAL G 171           
SHEET    1 AC8 2 TRP G 125  ASN G 131  0                                        
SHEET    2 AC8 2 GLU G 142  ARG G 147 -1  O  VAL G 143   N  VAL G 130           
SHEET    1 AC9 5 VAL G 318  ILE G 321  0                                        
SHEET    2 AC9 5 VAL G 435  VAL G 442 -1  O  LEU G 439   N  ILE G 321           
SHEET    3 AC9 5 PHE G 345  SER G 351 -1  N  ARG G 350   O  LYS G 436           
SHEET    4 AC9 5 TYR G 405  LEU G 410 -1  O  PHE G 406   N  LEU G 347           
SHEET    5 AC9 5 VAL G 385  PRO G 389 -1  N  ARG G 388   O  ALA G 407           
SHEET    1 AD1 4 GLN G 325  LYS G 326  0                                        
SHEET    2 AD1 4 MET G 329  ALA G 333 -1  O  MET G 329   N  LYS G 326           
SHEET    3 AD1 4 ARG G 423  TYR G 427 -1  O  CYS G 424   N  GLY G 332           
SHEET    4 AD1 4 LYS G 367  GLY G 369 -1  N  LYS G 367   O  TYR G 427           
SHEET    1 AD2 2 VAL H  44  PHE H  49  0                                        
SHEET    2 AD2 2 ALA H  61  VAL H  66 -1  O  ILE H  65   N  VAL H  45           
SHEET    1 AD3 4 THR H 151  MET H 154  0                                        
SHEET    2 AD3 4 LEU H  96  ALA H 102 -1  N  ALA H 102   O  THR H 151           
SHEET    3 AD3 4 CYS H 165  ARG H 172 -1  O  LEU H 170   N  VAL H  97           
SHEET    4 AD3 4 TRP H 178  ARG H 180 -1  O  CYS H 179   N  VAL H 171           
SHEET    1 AD4 2 TRP H 125  VAL H 132  0                                        
SHEET    2 AD4 2 SER H 141  HIS H 148 -1  O  VAL H 145   N  GLU H 128           
SHEET    1 AD5 2 GLU H 331  GLY H 332  0                                        
SHEET    2 AD5 2 CYS H 424  THR H 425 -1  O  CYS H 424   N  GLY H 332           
SHEET    1 AD6 2 PRO H 389  VAL H 390  0                                        
SHEET    2 AD6 2 TYR H 405  PHE H 406 -1  O  TYR H 405   N  VAL H 390           
SHEET    1 AD7 3 VAL I  44  ASP I  50  0                                        
SHEET    2 AD7 3 ARG I  58  PHE I  68 -1  O  ARG I  63   N  GLU I  48           
SHEET    3 AD7 3 THR I  72  ASP I  75 -1  O  THR I  72   N  PHE I  68           
SHEET    1 AD8 3 VAL I  44  ASP I  50  0                                        
SHEET    2 AD8 3 ARG I  58  PHE I  68 -1  O  ARG I  63   N  GLU I  48           
SHEET    3 AD8 3 CYS I  86  ASP I  87 -1  O  CYS I  86   N  LEU I  59           
SHEET    1 AD9 4 THR I 151  ARG I 153  0                                        
SHEET    2 AD9 4 VAL I  97  PRO I 104 -1  N  VAL I 100   O  ARG I 153           
SHEET    3 AD9 4 TRP I 162  ARG I 172 -1  O  LEU I 163   N  LEU I 103           
SHEET    4 AD9 4 TRP I 178  ARG I 180 -1  O  CYS I 179   N  VAL I 171           
SHEET    1 AE1 2 LYS I 126  VAL I 130  0                                        
SHEET    2 AE1 2 VAL I 143  ARG I 147 -1  O  VAL I 145   N  GLU I 128           
CISPEP   1 ILE B  313    ILE B  314          0        -1.17                     
CISPEP   2 GLY B  484    THR B  485          0        -1.59                     
CISPEP   3 ALA C  109    GLN C  110          0        13.96                     
CISPEP   4 ARG C  192    THR C  193          0        -3.55                     
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1           1          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      1.000000  0.000000  0.000000        0.00000                         
SCALE2      0.000000  1.000000  0.000000        0.00000                         
SCALE3      0.000000  0.000000  1.000000        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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