GenomeNet

Database: PDB
Entry: 6GL7
LinkDB: 6GL7
Original site: 6GL7 
HEADER    SIGNALING PROTEIN                       23-MAY-18   6GL7              
TITLE     NEURTURIN-GFRA2-RET EXTRACELLULAR COMPLEX                             
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: NEURTURIN;                                                 
COMPND   3 CHAIN: B, A;                                                         
COMPND   4 ENGINEERED: YES;                                                     
COMPND   5 MOL_ID: 2;                                                           
COMPND   6 MOLECULE: GDNF FAMILY RECEPTOR ALPHA-2;                              
COMPND   7 CHAIN: D, C;                                                         
COMPND   8 SYNONYM: GFR-ALPHA-2,GDNF RECEPTOR BETA,GDNFR-BETA,NEURTURIN RECEPTOR
COMPND   9 ALPHA,NTNR-ALPHA,RET LIGAND 2,TGF-BETA-RELATED NEUROTROPHIC FACTOR   
COMPND  10 RECEPTOR 2;                                                          
COMPND  11 ENGINEERED: YES;                                                     
COMPND  12 MOL_ID: 3;                                                           
COMPND  13 MOLECULE: PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET;       
COMPND  14 CHAIN: F, E;                                                         
COMPND  15 SYNONYM: CADHERIN FAMILY MEMBER 12,PROTO-ONCOGENE C-RET;             
COMPND  16 EC: 2.7.10.1;                                                        
COMPND  17 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   3 ORGANISM_COMMON: HUMAN;                                              
SOURCE   4 ORGANISM_TAXID: 9606;                                                
SOURCE   5 GENE: NRTN;                                                          
SOURCE   6 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE   8 MOL_ID: 2;                                                           
SOURCE   9 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  10 ORGANISM_COMMON: HUMAN;                                              
SOURCE  11 ORGANISM_TAXID: 9606;                                                
SOURCE  12 GENE: GFRA2, GDNFRB, RETL2, TRNR2;                                   
SOURCE  13 EXPRESSION_SYSTEM: CRICETULUS GRISEUS;                               
SOURCE  14 EXPRESSION_SYSTEM_TAXID: 10029;                                      
SOURCE  15 MOL_ID: 3;                                                           
SOURCE  16 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  17 ORGANISM_COMMON: HUMAN;                                              
SOURCE  18 ORGANISM_TAXID: 9606;                                                
SOURCE  19 GENE: RET, CDHF12, CDHR16, PTC, RET51;                               
SOURCE  20 EXPRESSION_SYSTEM: CRICETULUS GRISEUS;                               
SOURCE  21 EXPRESSION_SYSTEM_TAXID: 10029                                       
KEYWDS    NEUROTROPHIC SIGNALLING, RECEPTOR TYROSINE KINASE, GDNF FAMILY OF     
KEYWDS   2 LIGANDS, SIGNALING PROTEIN                                           
EXPDTA    ELECTRON MICROSCOPY                                                   
AUTHOR    J.M.BIGALKE,S.AIBARA,J.SANDMARK,A.AMUNTS                              
REVDAT   3   18-DEC-19 6GL7    1       SCALE                                    
REVDAT   2   21-AUG-19 6GL7    1       JRNL                                     
REVDAT   1   14-AUG-19 6GL7    0                                                
JRNL        AUTH   J.M.BIGALKE,S.AIBARA,R.ROTH,G.DAHL,E.GORDON,S.DORBEUS,       
JRNL        AUTH 2 A.AMUNTS,J.SANDMARK                                          
JRNL        TITL   CRYO-EM STRUCTURE OF THE ACTIVATED RET SIGNALING COMPLEX     
JRNL        TITL 2 REVEALS THE IMPORTANCE OF ITS CYSTEINE-RICH DOMAIN.          
JRNL        REF    SCI ADV                       V.   5 U4202 2019              
JRNL        REFN                   ESSN 2375-2548                               
JRNL        PMID   31392261                                                     
JRNL        DOI    10.1126/SCIADV.AAU4202                                       
REMARK   2                                                                      
REMARK   2 RESOLUTION.    6.30 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   SOFTWARE PACKAGES      : UCSF CHIMERA, COOT, PHENIX, ROSETTAEM,    
REMARK   3                            COOT                                      
REMARK   3   RECONSTRUCTION SCHEMA  : NULL                                      
REMARK   3                                                                      
REMARK   3 EM MAP-MODEL FITTING AND REFINEMENT                                  
REMARK   3   PDB ENTRY                    : NULL                                
REMARK   3   REFINEMENT SPACE             : REAL                                
REMARK   3   REFINEMENT PROTOCOL          : FLEXIBLE FIT                        
REMARK   3   REFINEMENT TARGET            : NULL                                
REMARK   3   OVERALL ANISOTROPIC B VALUE  : 220.000                             
REMARK   3                                                                      
REMARK   3 FITTING PROCEDURE : NULL                                             
REMARK   3                                                                      
REMARK   3 EM IMAGE RECONSTRUCTION STATISTICS                                   
REMARK   3   NOMINAL PIXEL SIZE (ANGSTROMS)    : NULL                           
REMARK   3   ACTUAL PIXEL SIZE  (ANGSTROMS)    : NULL                           
REMARK   3   EFFECTIVE RESOLUTION (ANGSTROMS)  : 6.300                          
REMARK   3   NUMBER OF PARTICLES               : 186903                         
REMARK   3   CTF CORRECTION METHOD             : PHASE FLIPPING AND AMPLITUDE   
REMARK   3                                       CORRECTION                     
REMARK   3                                                                      
REMARK   3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL                    
REMARK   3                                                                      
REMARK   3 OTHER DETAILS: NULL                                                  
REMARK   4                                                                      
REMARK   4 6GL7 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 23-MAY-18.                  
REMARK 100 THE DEPOSITION ID IS D_1200009732.                                   
REMARK 245                                                                      
REMARK 245 EXPERIMENTAL DETAILS                                                 
REMARK 245   RECONSTRUCTION METHOD          : SINGLE PARTICLE                   
REMARK 245   SPECIMEN TYPE                  : NULL                              
REMARK 245                                                                      
REMARK 245 ELECTRON MICROSCOPE SAMPLE                                           
REMARK 245   SAMPLE TYPE                    : PARTICLE                          
REMARK 245   PARTICLE TYPE                  : POINT                             
REMARK 245   NAME OF SAMPLE                 : NEURTURIN-GFRA2-RET               
REMARK 245                                    EXTRACELLULAR COMPLEX;            
REMARK 245                                    NEURTURIN; GDNF FAMILY RECEPTOR   
REMARK 245                                    ALPHA-2; PROTO-ONCOGENE           
REMARK 245                                    TYROSINE-PROTEIN KINASE           
REMARK 245                                    RECEPTOR RET                      
REMARK 245   SAMPLE CONCENTRATION (MG ML-1) : NULL                              
REMARK 245   SAMPLE SUPPORT DETAILS         : NULL                              
REMARK 245   SAMPLE VITRIFICATION DETAILS   : NULL                              
REMARK 245   SAMPLE BUFFER                  : NULL                              
REMARK 245   PH                             : 8.00                              
REMARK 245   SAMPLE DETAILS                 : NULL                              
REMARK 245                                                                      
REMARK 245 DATA ACQUISITION                                                     
REMARK 245   DATE OF EXPERIMENT                : NULL                           
REMARK 245   NUMBER OF MICROGRAPHS-IMAGES      : NULL                           
REMARK 245   TEMPERATURE (KELVIN)              : NULL                           
REMARK 245   MICROSCOPE MODEL                  : FEI TITAN KRIOS                
REMARK 245   DETECTOR TYPE                     : GATAN K2 QUANTUM (4K X 4K)     
REMARK 245   MINIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MAXIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MINIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   MAXIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   NOMINAL CS                        : NULL                           
REMARK 245   IMAGING MODE                      : BRIGHT FIELD                   
REMARK 245   ELECTRON DOSE (ELECTRONS NM**-2)  : 38.00                          
REMARK 245   ILLUMINATION MODE                 : FLOOD BEAM                     
REMARK 245   NOMINAL MAGNIFICATION             : NULL                           
REMARK 245   CALIBRATED MAGNIFICATION          : NULL                           
REMARK 245   SOURCE                            : FIELD EMISSION GUN             
REMARK 245   ACCELERATION VOLTAGE (KV)         : 300                            
REMARK 245   IMAGING DETAILS                   : NULL                           
REMARK 247                                                                      
REMARK 247 ELECTRON MICROSCOPY                                                  
REMARK 247  THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON          
REMARK 247  MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE              
REMARK 247  THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES           
REMARK 247  ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION         
REMARK 247  OF THE STRUCTURE FACTORS.                                           
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: HEXAMERIC                         
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: HEXAMERIC                  
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 10460 ANGSTROM**2                         
REMARK 350 SURFACE AREA OF THE COMPLEX: 82960 ANGSTROM**2                       
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -5.0 KCAL/MOL                         
REMARK 350 APPLY THE FOLLOWING TO CHAINS: B, D, A, C, F, E                      
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     ALA B    96                                                      
REMARK 465     ARG B    97                                                      
REMARK 465     SER D    22                                                      
REMARK 465     PRO D    23                                                      
REMARK 465     SER D    24                                                      
REMARK 465     SER D    25                                                      
REMARK 465     LEU D    26                                                      
REMARK 465     GLN D    27                                                      
REMARK 465     GLY D    28                                                      
REMARK 465     PRO D    29                                                      
REMARK 465     GLU D    30                                                      
REMARK 465     LEU D    31                                                      
REMARK 465     HIS D    32                                                      
REMARK 465     GLY D    33                                                      
REMARK 465     TRP D    34                                                      
REMARK 465     ARG D    35                                                      
REMARK 465     PRO D    36                                                      
REMARK 465     PRO D    37                                                      
REMARK 465     VAL D    38                                                      
REMARK 465     LEU D    64                                                      
REMARK 465     ALA D    65                                                      
REMARK 465     GLY D    66                                                      
REMARK 465     ARG D    67                                                      
REMARK 465     ASP D    68                                                      
REMARK 465     ARG D    69                                                      
REMARK 465     ASN D    70                                                      
REMARK 465     THR D    71                                                      
REMARK 465     MET D    72                                                      
REMARK 465     LEU D   116                                                      
REMARK 465     THR D   117                                                      
REMARK 465     GLU D   118                                                      
REMARK 465     GLY D   119                                                      
REMARK 465     GLU D   120                                                      
REMARK 465     THR D   148                                                      
REMARK 465     GLY D   149                                                      
REMARK 465     ALA D   150                                                      
REMARK 465     ASP D   151                                                      
REMARK 465     PRO D   152                                                      
REMARK 465     VAL D   153                                                      
REMARK 465     VAL D   154                                                      
REMARK 465     SER D   155                                                      
REMARK 465     ALA D   156                                                      
REMARK 465     LYS D   157                                                      
REMARK 465     ASP D   360                                                      
REMARK 465     VAL D   361                                                      
REMARK 465     ASN D   362                                                      
REMARK 465     VAL D   363                                                      
REMARK 465     SER D   364                                                      
REMARK 465     PRO D   365                                                      
REMARK 465     LYS D   366                                                      
REMARK 465     GLY D   367                                                      
REMARK 465     PRO D   368                                                      
REMARK 465     SER D   369                                                      
REMARK 465     PHE D   370                                                      
REMARK 465     GLN D   371                                                      
REMARK 465     ALA D   372                                                      
REMARK 465     THR D   373                                                      
REMARK 465     GLN D   374                                                      
REMARK 465     ALA D   375                                                      
REMARK 465     PRO D   376                                                      
REMARK 465     ARG D   377                                                      
REMARK 465     VAL D   378                                                      
REMARK 465     GLU D   379                                                      
REMARK 465     LYS D   380                                                      
REMARK 465     THR D   381                                                      
REMARK 465     PRO D   382                                                      
REMARK 465     SER D   383                                                      
REMARK 465     LEU D   384                                                      
REMARK 465     PRO D   385                                                      
REMARK 465     ASP D   386                                                      
REMARK 465     ASP D   387                                                      
REMARK 465     LEU D   388                                                      
REMARK 465     SER D   389                                                      
REMARK 465     ASP D   390                                                      
REMARK 465     SER D   391                                                      
REMARK 465     THR D   392                                                      
REMARK 465     SER D   393                                                      
REMARK 465     LEU D   394                                                      
REMARK 465     GLY D   395                                                      
REMARK 465     THR D   396                                                      
REMARK 465     SER D   397                                                      
REMARK 465     VAL D   398                                                      
REMARK 465     ILE D   399                                                      
REMARK 465     THR D   400                                                      
REMARK 465     THR D   401                                                      
REMARK 465     CYS D   402                                                      
REMARK 465     THR D   403                                                      
REMARK 465     SER D   404                                                      
REMARK 465     VAL D   405                                                      
REMARK 465     GLN D   406                                                      
REMARK 465     GLU D   407                                                      
REMARK 465     GLN D   408                                                      
REMARK 465     GLY D   409                                                      
REMARK 465     LEU D   410                                                      
REMARK 465     LYS D   411                                                      
REMARK 465     ALA D   412                                                      
REMARK 465     ASN D   413                                                      
REMARK 465     ASN D   414                                                      
REMARK 465     SER D   415                                                      
REMARK 465     LYS D   416                                                      
REMARK 465     GLU D   417                                                      
REMARK 465     LEU D   418                                                      
REMARK 465     SER D   419                                                      
REMARK 465     MET D   420                                                      
REMARK 465     CYS D   421                                                      
REMARK 465     PHE D   422                                                      
REMARK 465     THR D   423                                                      
REMARK 465     GLU D   424                                                      
REMARK 465     LEU D   425                                                      
REMARK 465     THR D   426                                                      
REMARK 465     THR D   427                                                      
REMARK 465     ASN D   428                                                      
REMARK 465     ILE D   429                                                      
REMARK 465     ILE D   430                                                      
REMARK 465     PRO D   431                                                      
REMARK 465     GLY D   432                                                      
REMARK 465     SER D   433                                                      
REMARK 465     ASN D   434                                                      
REMARK 465     LYS D   435                                                      
REMARK 465     VAL D   436                                                      
REMARK 465     ILE D   437                                                      
REMARK 465     LYS D   438                                                      
REMARK 465     PRO D   439                                                      
REMARK 465     ASN D   440                                                      
REMARK 465     SER D   441                                                      
REMARK 465     HIS D   442                                                      
REMARK 465     HIS D   443                                                      
REMARK 465     HIS D   444                                                      
REMARK 465     HIS D   445                                                      
REMARK 465     HIS D   446                                                      
REMARK 465     HIS D   447                                                      
REMARK 465     ALA A    96                                                      
REMARK 465     ARG A    97                                                      
REMARK 465     SER C    22                                                      
REMARK 465     PRO C    23                                                      
REMARK 465     SER C    24                                                      
REMARK 465     SER C    25                                                      
REMARK 465     LEU C    26                                                      
REMARK 465     GLN C    27                                                      
REMARK 465     GLY C    28                                                      
REMARK 465     PRO C    29                                                      
REMARK 465     GLU C    30                                                      
REMARK 465     LEU C    31                                                      
REMARK 465     HIS C    32                                                      
REMARK 465     GLY C    33                                                      
REMARK 465     TRP C    34                                                      
REMARK 465     ARG C    35                                                      
REMARK 465     PRO C    36                                                      
REMARK 465     PRO C    37                                                      
REMARK 465     VAL C    38                                                      
REMARK 465     LEU C    64                                                      
REMARK 465     ALA C    65                                                      
REMARK 465     GLY C    66                                                      
REMARK 465     ARG C    67                                                      
REMARK 465     ASP C    68                                                      
REMARK 465     ARG C    69                                                      
REMARK 465     ASN C    70                                                      
REMARK 465     THR C    71                                                      
REMARK 465     MET C    72                                                      
REMARK 465     LEU C   116                                                      
REMARK 465     THR C   117                                                      
REMARK 465     GLU C   118                                                      
REMARK 465     GLY C   119                                                      
REMARK 465     GLU C   120                                                      
REMARK 465     THR C   148                                                      
REMARK 465     GLY C   149                                                      
REMARK 465     ALA C   150                                                      
REMARK 465     ASP C   151                                                      
REMARK 465     PRO C   152                                                      
REMARK 465     VAL C   153                                                      
REMARK 465     VAL C   154                                                      
REMARK 465     SER C   155                                                      
REMARK 465     ALA C   156                                                      
REMARK 465     LYS C   157                                                      
REMARK 465     ASP C   360                                                      
REMARK 465     VAL C   361                                                      
REMARK 465     ASN C   362                                                      
REMARK 465     VAL C   363                                                      
REMARK 465     SER C   364                                                      
REMARK 465     PRO C   365                                                      
REMARK 465     LYS C   366                                                      
REMARK 465     GLY C   367                                                      
REMARK 465     PRO C   368                                                      
REMARK 465     SER C   369                                                      
REMARK 465     PHE C   370                                                      
REMARK 465     GLN C   371                                                      
REMARK 465     ALA C   372                                                      
REMARK 465     THR C   373                                                      
REMARK 465     GLN C   374                                                      
REMARK 465     ALA C   375                                                      
REMARK 465     PRO C   376                                                      
REMARK 465     ARG C   377                                                      
REMARK 465     VAL C   378                                                      
REMARK 465     GLU C   379                                                      
REMARK 465     LYS C   380                                                      
REMARK 465     THR C   381                                                      
REMARK 465     PRO C   382                                                      
REMARK 465     SER C   383                                                      
REMARK 465     LEU C   384                                                      
REMARK 465     PRO C   385                                                      
REMARK 465     ASP C   386                                                      
REMARK 465     ASP C   387                                                      
REMARK 465     LEU C   388                                                      
REMARK 465     SER C   389                                                      
REMARK 465     ASP C   390                                                      
REMARK 465     SER C   391                                                      
REMARK 465     THR C   392                                                      
REMARK 465     SER C   393                                                      
REMARK 465     LEU C   394                                                      
REMARK 465     GLY C   395                                                      
REMARK 465     THR C   396                                                      
REMARK 465     SER C   397                                                      
REMARK 465     VAL C   398                                                      
REMARK 465     ILE C   399                                                      
REMARK 465     THR C   400                                                      
REMARK 465     THR C   401                                                      
REMARK 465     CYS C   402                                                      
REMARK 465     THR C   403                                                      
REMARK 465     SER C   404                                                      
REMARK 465     VAL C   405                                                      
REMARK 465     GLN C   406                                                      
REMARK 465     GLU C   407                                                      
REMARK 465     GLN C   408                                                      
REMARK 465     GLY C   409                                                      
REMARK 465     LEU C   410                                                      
REMARK 465     LYS C   411                                                      
REMARK 465     ALA C   412                                                      
REMARK 465     ASN C   413                                                      
REMARK 465     ASN C   414                                                      
REMARK 465     SER C   415                                                      
REMARK 465     LYS C   416                                                      
REMARK 465     GLU C   417                                                      
REMARK 465     LEU C   418                                                      
REMARK 465     SER C   419                                                      
REMARK 465     MET C   420                                                      
REMARK 465     CYS C   421                                                      
REMARK 465     PHE C   422                                                      
REMARK 465     THR C   423                                                      
REMARK 465     GLU C   424                                                      
REMARK 465     LEU C   425                                                      
REMARK 465     THR C   426                                                      
REMARK 465     THR C   427                                                      
REMARK 465     ASN C   428                                                      
REMARK 465     ILE C   429                                                      
REMARK 465     ILE C   430                                                      
REMARK 465     PRO C   431                                                      
REMARK 465     GLY C   432                                                      
REMARK 465     SER C   433                                                      
REMARK 465     ASN C   434                                                      
REMARK 465     LYS C   435                                                      
REMARK 465     VAL C   436                                                      
REMARK 465     ILE C   437                                                      
REMARK 465     LYS C   438                                                      
REMARK 465     PRO C   439                                                      
REMARK 465     ASN C   440                                                      
REMARK 465     SER C   441                                                      
REMARK 465     HIS C   442                                                      
REMARK 465     HIS C   443                                                      
REMARK 465     HIS C   444                                                      
REMARK 465     HIS C   445                                                      
REMARK 465     HIS C   446                                                      
REMARK 465     HIS C   447                                                      
REMARK 465     SER F   131                                                      
REMARK 465     LEU F   132                                                      
REMARK 465     ARG F   133                                                      
REMARK 465     ALA F   247                                                      
REMARK 465     GLY F   248                                                      
REMARK 465     ALA F   249                                                      
REMARK 465     ASP F   378                                                      
REMARK 465     SER F   379                                                      
REMARK 465     ASP F   380                                                      
REMARK 465     PHE F   381                                                      
REMARK 465     GLN F   382                                                      
REMARK 465     GLY F   383                                                      
REMARK 465     PRO F   384                                                      
REMARK 465     GLY F   385                                                      
REMARK 465     ALA F   386                                                      
REMARK 465     GLY F   387                                                      
REMARK 465     VAL F   388                                                      
REMARK 465     LEU F   389                                                      
REMARK 465     LEU F   390                                                      
REMARK 465     LEU F   391                                                      
REMARK 465     HIS F   392                                                      
REMARK 465     PHE F   393                                                      
REMARK 465     ASN F   394                                                      
REMARK 465     VAL F   395                                                      
REMARK 465     SER F   396                                                      
REMARK 465     VAL F   397                                                      
REMARK 465     LEU F   398                                                      
REMARK 465     GLY F   506                                                      
REMARK 465     SER F   507                                                      
REMARK 465     TYR F   508                                                      
REMARK 465     VAL F   509                                                      
REMARK 465     ALA F   510                                                      
REMARK 465     GLU F   511                                                      
REMARK 465     GLU F   512                                                      
REMARK 465     ALA F   513                                                      
REMARK 465     GLY F   514                                                      
REMARK 465     CYS F   515                                                      
REMARK 465     PRO F   516                                                      
REMARK 465     LEU F   517                                                      
REMARK 465     SER F   518                                                      
REMARK 465     CYS F   519                                                      
REMARK 465     ALA F   520                                                      
REMARK 465     VAL F   521                                                      
REMARK 465     SER F   522                                                      
REMARK 465     LYS F   523                                                      
REMARK 465     ARG F   524                                                      
REMARK 465     ARG F   525                                                      
REMARK 465     LEU F   526                                                      
REMARK 465     GLU F   527                                                      
REMARK 465     CYS F   528                                                      
REMARK 465     GLU F   529                                                      
REMARK 465     GLU F   530                                                      
REMARK 465     CYS F   531                                                      
REMARK 465     GLY F   532                                                      
REMARK 465     GLY F   533                                                      
REMARK 465     LEU F   534                                                      
REMARK 465     GLY F   535                                                      
REMARK 465     SER F   536                                                      
REMARK 465     PRO F   537                                                      
REMARK 465     THR F   538                                                      
REMARK 465     GLY F   539                                                      
REMARK 465     ARG F   540                                                      
REMARK 465     CYS F   541                                                      
REMARK 465     GLU F   542                                                      
REMARK 465     TRP F   543                                                      
REMARK 465     ARG F   544                                                      
REMARK 465     GLN F   545                                                      
REMARK 465     GLY F   546                                                      
REMARK 465     ASP F   547                                                      
REMARK 465     GLY F   548                                                      
REMARK 465     LYS F   549                                                      
REMARK 465     GLY F   550                                                      
REMARK 465     ILE F   551                                                      
REMARK 465     THR F   552                                                      
REMARK 465     ARG F   553                                                      
REMARK 465     ASN F   554                                                      
REMARK 465     PHE F   555                                                      
REMARK 465     SER F   556                                                      
REMARK 465     THR F   557                                                      
REMARK 465     CYS F   558                                                      
REMARK 465     SER F   559                                                      
REMARK 465     PRO F   560                                                      
REMARK 465     SER F   561                                                      
REMARK 465     THR F   562                                                      
REMARK 465     LYS F   563                                                      
REMARK 465     THR F   564                                                      
REMARK 465     CYS F   565                                                      
REMARK 465     PRO F   566                                                      
REMARK 465     ASP F   567                                                      
REMARK 465     GLY F   568                                                      
REMARK 465     HIS F   569                                                      
REMARK 465     CYS F   570                                                      
REMARK 465     ASP F   571                                                      
REMARK 465     VAL F   572                                                      
REMARK 465     VAL F   573                                                      
REMARK 465     GLU F   574                                                      
REMARK 465     THR F   575                                                      
REMARK 465     GLN F   576                                                      
REMARK 465     ASP F   577                                                      
REMARK 465     ILE F   578                                                      
REMARK 465     ASN F   579                                                      
REMARK 465     ILE F   580                                                      
REMARK 465     CYS F   581                                                      
REMARK 465     PRO F   582                                                      
REMARK 465     GLN F   583                                                      
REMARK 465     ASP F   584                                                      
REMARK 465     CYS F   585                                                      
REMARK 465     LEU F   586                                                      
REMARK 465     ARG F   587                                                      
REMARK 465     GLY F   588                                                      
REMARK 465     SER F   589                                                      
REMARK 465     ILE F   590                                                      
REMARK 465     VAL F   591                                                      
REMARK 465     GLY F   592                                                      
REMARK 465     GLY F   593                                                      
REMARK 465     HIS F   594                                                      
REMARK 465     GLU F   595                                                      
REMARK 465     PRO F   596                                                      
REMARK 465     GLY F   597                                                      
REMARK 465     GLU F   598                                                      
REMARK 465     PRO F   599                                                      
REMARK 465     ARG F   600                                                      
REMARK 465     GLY F   601                                                      
REMARK 465     ILE F   602                                                      
REMARK 465     LYS F   603                                                      
REMARK 465     ALA F   604                                                      
REMARK 465     GLY F   605                                                      
REMARK 465     TYR F   606                                                      
REMARK 465     GLY F   607                                                      
REMARK 465     THR F   608                                                      
REMARK 465     CYS F   609                                                      
REMARK 465     ASN F   610                                                      
REMARK 465     CYS F   611                                                      
REMARK 465     PHE F   612                                                      
REMARK 465     PRO F   613                                                      
REMARK 465     GLU F   614                                                      
REMARK 465     GLU F   615                                                      
REMARK 465     GLU F   616                                                      
REMARK 465     LYS F   617                                                      
REMARK 465     CYS F   618                                                      
REMARK 465     PHE F   619                                                      
REMARK 465     CYS F   620                                                      
REMARK 465     GLU F   621                                                      
REMARK 465     PRO F   622                                                      
REMARK 465     GLU F   623                                                      
REMARK 465     ASP F   624                                                      
REMARK 465     ILE F   625                                                      
REMARK 465     GLN F   626                                                      
REMARK 465     ASP F   627                                                      
REMARK 465     PRO F   628                                                      
REMARK 465     LEU F   629                                                      
REMARK 465     CYS F   630                                                      
REMARK 465     ASP F   631                                                      
REMARK 465     GLU F   632                                                      
REMARK 465     LEU F   633                                                      
REMARK 465     CYS F   634                                                      
REMARK 465     ARG F   635                                                      
REMARK 465     GLU F   636                                                      
REMARK 465     ASN F   637                                                      
REMARK 465     LEU F   638                                                      
REMARK 465     TYR F   639                                                      
REMARK 465     PHE F   640                                                      
REMARK 465     GLN F   641                                                      
REMARK 465     SER E   131                                                      
REMARK 465     LEU E   132                                                      
REMARK 465     ARG E   133                                                      
REMARK 465     ALA E   247                                                      
REMARK 465     GLY E   248                                                      
REMARK 465     ALA E   249                                                      
REMARK 465     ASP E   378                                                      
REMARK 465     SER E   379                                                      
REMARK 465     ASP E   380                                                      
REMARK 465     PHE E   381                                                      
REMARK 465     GLN E   382                                                      
REMARK 465     GLY E   383                                                      
REMARK 465     PRO E   384                                                      
REMARK 465     GLY E   385                                                      
REMARK 465     ALA E   386                                                      
REMARK 465     GLY E   387                                                      
REMARK 465     VAL E   388                                                      
REMARK 465     LEU E   389                                                      
REMARK 465     LEU E   390                                                      
REMARK 465     LEU E   391                                                      
REMARK 465     HIS E   392                                                      
REMARK 465     PHE E   393                                                      
REMARK 465     ASN E   394                                                      
REMARK 465     VAL E   395                                                      
REMARK 465     SER E   396                                                      
REMARK 465     VAL E   397                                                      
REMARK 465     LEU E   398                                                      
REMARK 465     GLY E   506                                                      
REMARK 465     SER E   507                                                      
REMARK 465     TYR E   508                                                      
REMARK 465     VAL E   509                                                      
REMARK 465     ALA E   510                                                      
REMARK 465     GLU E   511                                                      
REMARK 465     GLU E   512                                                      
REMARK 465     ALA E   513                                                      
REMARK 465     GLY E   514                                                      
REMARK 465     CYS E   515                                                      
REMARK 465     PRO E   516                                                      
REMARK 465     LEU E   517                                                      
REMARK 465     SER E   518                                                      
REMARK 465     CYS E   519                                                      
REMARK 465     ALA E   520                                                      
REMARK 465     VAL E   521                                                      
REMARK 465     SER E   522                                                      
REMARK 465     LYS E   523                                                      
REMARK 465     ARG E   524                                                      
REMARK 465     ARG E   525                                                      
REMARK 465     LEU E   526                                                      
REMARK 465     GLU E   527                                                      
REMARK 465     CYS E   528                                                      
REMARK 465     GLU E   529                                                      
REMARK 465     GLU E   530                                                      
REMARK 465     CYS E   531                                                      
REMARK 465     GLY E   532                                                      
REMARK 465     GLY E   533                                                      
REMARK 465     LEU E   534                                                      
REMARK 465     GLY E   535                                                      
REMARK 465     SER E   536                                                      
REMARK 465     PRO E   537                                                      
REMARK 465     THR E   538                                                      
REMARK 465     GLY E   539                                                      
REMARK 465     ARG E   540                                                      
REMARK 465     CYS E   541                                                      
REMARK 465     GLU E   542                                                      
REMARK 465     TRP E   543                                                      
REMARK 465     ARG E   544                                                      
REMARK 465     GLN E   545                                                      
REMARK 465     GLY E   546                                                      
REMARK 465     ASP E   547                                                      
REMARK 465     GLY E   548                                                      
REMARK 465     LYS E   549                                                      
REMARK 465     GLY E   550                                                      
REMARK 465     ILE E   551                                                      
REMARK 465     THR E   552                                                      
REMARK 465     ARG E   553                                                      
REMARK 465     ASN E   554                                                      
REMARK 465     PHE E   555                                                      
REMARK 465     SER E   556                                                      
REMARK 465     THR E   557                                                      
REMARK 465     CYS E   558                                                      
REMARK 465     SER E   559                                                      
REMARK 465     PRO E   560                                                      
REMARK 465     SER E   561                                                      
REMARK 465     THR E   562                                                      
REMARK 465     LYS E   563                                                      
REMARK 465     THR E   564                                                      
REMARK 465     CYS E   565                                                      
REMARK 465     PRO E   566                                                      
REMARK 465     ASP E   567                                                      
REMARK 465     GLY E   568                                                      
REMARK 465     HIS E   569                                                      
REMARK 465     CYS E   570                                                      
REMARK 465     ASP E   571                                                      
REMARK 465     VAL E   572                                                      
REMARK 465     VAL E   573                                                      
REMARK 465     GLU E   574                                                      
REMARK 465     THR E   575                                                      
REMARK 465     GLN E   576                                                      
REMARK 465     ASP E   577                                                      
REMARK 465     ILE E   578                                                      
REMARK 465     ASN E   579                                                      
REMARK 465     ILE E   580                                                      
REMARK 465     CYS E   581                                                      
REMARK 465     PRO E   582                                                      
REMARK 465     GLN E   583                                                      
REMARK 465     ASP E   584                                                      
REMARK 465     CYS E   585                                                      
REMARK 465     LEU E   586                                                      
REMARK 465     ARG E   587                                                      
REMARK 465     GLY E   588                                                      
REMARK 465     SER E   589                                                      
REMARK 465     ILE E   590                                                      
REMARK 465     VAL E   591                                                      
REMARK 465     GLY E   592                                                      
REMARK 465     GLY E   593                                                      
REMARK 465     HIS E   594                                                      
REMARK 465     GLU E   595                                                      
REMARK 465     PRO E   596                                                      
REMARK 465     GLY E   597                                                      
REMARK 465     GLU E   598                                                      
REMARK 465     PRO E   599                                                      
REMARK 465     ARG E   600                                                      
REMARK 465     GLY E   601                                                      
REMARK 465     ILE E   602                                                      
REMARK 465     LYS E   603                                                      
REMARK 465     ALA E   604                                                      
REMARK 465     GLY E   605                                                      
REMARK 465     TYR E   606                                                      
REMARK 465     GLY E   607                                                      
REMARK 465     THR E   608                                                      
REMARK 465     CYS E   609                                                      
REMARK 465     ASN E   610                                                      
REMARK 465     CYS E   611                                                      
REMARK 465     PHE E   612                                                      
REMARK 465     PRO E   613                                                      
REMARK 465     GLU E   614                                                      
REMARK 465     GLU E   615                                                      
REMARK 465     GLU E   616                                                      
REMARK 465     LYS E   617                                                      
REMARK 465     CYS E   618                                                      
REMARK 465     PHE E   619                                                      
REMARK 465     CYS E   620                                                      
REMARK 465     GLU E   621                                                      
REMARK 465     PRO E   622                                                      
REMARK 465     GLU E   623                                                      
REMARK 465     ASP E   624                                                      
REMARK 465     ILE E   625                                                      
REMARK 465     GLN E   626                                                      
REMARK 465     ASP E   627                                                      
REMARK 465     PRO E   628                                                      
REMARK 465     LEU E   629                                                      
REMARK 465     CYS E   630                                                      
REMARK 465     ASP E   631                                                      
REMARK 465     GLU E   632                                                      
REMARK 465     LEU E   633                                                      
REMARK 465     CYS E   634                                                      
REMARK 465     ARG E   635                                                      
REMARK 465     GLU E   636                                                      
REMARK 465     ASN E   637                                                      
REMARK 465     LEU E   638                                                      
REMARK 465     TYR E   639                                                      
REMARK 465     PHE E   640                                                      
REMARK 465     GLN E   641                                                      
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   HG1  THR E    75    HD21  ASN E   113              1.20            
REMARK 500   HA3  GLY D   329     HB2  ALA E   306              1.29            
REMARK 500   HG1  THR F    75    HD21  ASN F   113              1.29            
REMARK 500   O    GLY D   327     H    SER E   307              1.42            
REMARK 500   H    GLU D   121     NH2  ARG E    77              1.51            
REMARK 500   OG1  THR F   271     HG3  ARG F   368              1.57            
REMARK 500   OG   SER F   224    HH12  ARG F   226              1.59            
REMARK 500   OG   SER E   224    HH12  ARG E   226              1.59            
REMARK 500   O    ALA E    45     HG1  THR E    48              1.60            
REMARK 500   O    ALA F    45     HG1  THR F    48              1.60            
REMARK 500   CG2  THR E   271     CB   ASP E   300              2.18            
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500    CYS D  63   CA  -  CB  -  SG  ANGL. DEV. =   6.8 DEGREES          
REMARK 500    CYS C  63   CA  -  CB  -  SG  ANGL. DEV. =   6.8 DEGREES          
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    ARG B 158       84.20    -68.01                                   
REMARK 500    SER D 126       54.18   -116.73                                   
REMARK 500    CYS D 241      -52.56   -120.66                                   
REMARK 500    THR D 306      106.30    -42.83                                   
REMARK 500    PRO D 321     -177.45    -66.03                                   
REMARK 500    TRP D 322       78.02   -101.15                                   
REMARK 500    ARG A 158       83.57    -66.43                                   
REMARK 500    SER C 126       54.96   -118.39                                   
REMARK 500    CYS C 241      -53.23   -121.40                                   
REMARK 500    THR C 306      106.41    -46.92                                   
REMARK 500    PRO C 321     -177.80    -67.45                                   
REMARK 500    TRP C 322       76.28   -102.21                                   
REMARK 500    THR F  48      104.36    -48.19                                   
REMARK 500    HIS F 186      149.67   -170.14                                   
REMARK 500    LYS F 286       76.65   -103.10                                   
REMARK 500    ASP F 302      -62.29   -100.48                                   
REMARK 500    THR F 328      -64.88   -123.00                                   
REMARK 500    SER F 363       -0.80     77.93                                   
REMARK 500    ARG F 418      -34.93   -135.35                                   
REMARK 500    GLN F 439       65.66     65.96                                   
REMARK 500    GLN F 497      145.02   -175.70                                   
REMARK 500    THR E  48      104.35    -48.20                                   
REMARK 500    HIS E 186      149.65   -170.17                                   
REMARK 500    ASP E 267      -37.48   -130.42                                   
REMARK 500    LYS E 286       76.66   -103.11                                   
REMARK 500    ASP E 302      -62.27   -100.52                                   
REMARK 500    THR E 328      -64.91   -123.03                                   
REMARK 500    SER E 363       -0.84     77.95                                   
REMARK 500    ARG E 418      -34.97   -135.33                                   
REMARK 500    GLN E 439       65.72     65.91                                   
REMARK 500    GLN E 497      145.03   -175.68                                   
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: EMD-0026   RELATED DB: EMDB                              
REMARK 900 NEURTURIN-GFRA2-RET EXTRACELLULAR COMPLEX                            
DBREF  6GL7 B   96   197  UNP    Q99748   NRTN_HUMAN      96    197             
DBREF  6GL7 D   22   441  UNP    O00451   GFRA2_HUMAN     22    441             
DBREF  6GL7 A   96   197  UNP    Q99748   NRTN_HUMAN      96    197             
DBREF  6GL7 C   22   441  UNP    O00451   GFRA2_HUMAN     22    441             
DBREF  6GL7 F   29   635  UNP    P07949   RET_HUMAN       29    635             
DBREF  6GL7 E   29   635  UNP    P07949   RET_HUMAN       29    635             
SEQADV 6GL7 HIS D  442  UNP  O00451              EXPRESSION TAG                 
SEQADV 6GL7 HIS D  443  UNP  O00451              EXPRESSION TAG                 
SEQADV 6GL7 HIS D  444  UNP  O00451              EXPRESSION TAG                 
SEQADV 6GL7 HIS D  445  UNP  O00451              EXPRESSION TAG                 
SEQADV 6GL7 HIS D  446  UNP  O00451              EXPRESSION TAG                 
SEQADV 6GL7 HIS D  447  UNP  O00451              EXPRESSION TAG                 
SEQADV 6GL7 HIS C  442  UNP  O00451              EXPRESSION TAG                 
SEQADV 6GL7 HIS C  443  UNP  O00451              EXPRESSION TAG                 
SEQADV 6GL7 HIS C  444  UNP  O00451              EXPRESSION TAG                 
SEQADV 6GL7 HIS C  445  UNP  O00451              EXPRESSION TAG                 
SEQADV 6GL7 HIS C  446  UNP  O00451              EXPRESSION TAG                 
SEQADV 6GL7 HIS C  447  UNP  O00451              EXPRESSION TAG                 
SEQADV 6GL7 GLU F  636  UNP  P07949              EXPRESSION TAG                 
SEQADV 6GL7 ASN F  637  UNP  P07949              EXPRESSION TAG                 
SEQADV 6GL7 LEU F  638  UNP  P07949              EXPRESSION TAG                 
SEQADV 6GL7 TYR F  639  UNP  P07949              EXPRESSION TAG                 
SEQADV 6GL7 PHE F  640  UNP  P07949              EXPRESSION TAG                 
SEQADV 6GL7 GLN F  641  UNP  P07949              EXPRESSION TAG                 
SEQADV 6GL7 GLU E  636  UNP  P07949              EXPRESSION TAG                 
SEQADV 6GL7 ASN E  637  UNP  P07949              EXPRESSION TAG                 
SEQADV 6GL7 LEU E  638  UNP  P07949              EXPRESSION TAG                 
SEQADV 6GL7 TYR E  639  UNP  P07949              EXPRESSION TAG                 
SEQADV 6GL7 PHE E  640  UNP  P07949              EXPRESSION TAG                 
SEQADV 6GL7 GLN E  641  UNP  P07949              EXPRESSION TAG                 
SEQRES   1 B  102  ALA ARG LEU GLY ALA ARG PRO CYS GLY LEU ARG GLU LEU          
SEQRES   2 B  102  GLU VAL ARG VAL SER GLU LEU GLY LEU GLY TYR ALA SER          
SEQRES   3 B  102  ASP GLU THR VAL LEU PHE ARG TYR CYS ALA GLY ALA CYS          
SEQRES   4 B  102  GLU ALA ALA ALA ARG VAL TYR ASP LEU GLY LEU ARG ARG          
SEQRES   5 B  102  LEU ARG GLN ARG ARG ARG LEU ARG ARG GLU ARG VAL ARG          
SEQRES   6 B  102  ALA GLN PRO CYS CYS ARG PRO THR ALA TYR GLU ASP GLU          
SEQRES   7 B  102  VAL SER PHE LEU ASP ALA HIS SER ARG TYR HIS THR VAL          
SEQRES   8 B  102  HIS GLU LEU SER ALA ARG GLU CYS ALA CYS VAL                  
SEQRES   1 D  426  SER PRO SER SER LEU GLN GLY PRO GLU LEU HIS GLY TRP          
SEQRES   2 D  426  ARG PRO PRO VAL ASP CYS VAL ARG ALA ASN GLU LEU CYS          
SEQRES   3 D  426  ALA ALA GLU SER ASN CYS SER SER ARG TYR ARG THR LEU          
SEQRES   4 D  426  ARG GLN CYS LEU ALA GLY ARG ASP ARG ASN THR MET LEU          
SEQRES   5 D  426  ALA ASN LYS GLU CYS GLN ALA ALA LEU GLU VAL LEU GLN          
SEQRES   6 D  426  GLU SER PRO LEU TYR ASP CYS ARG CYS LYS ARG GLY MET          
SEQRES   7 D  426  LYS LYS GLU LEU GLN CYS LEU GLN ILE TYR TRP SER ILE          
SEQRES   8 D  426  HIS LEU GLY LEU THR GLU GLY GLU GLU PHE TYR GLU ALA          
SEQRES   9 D  426  SER PRO TYR GLU PRO VAL THR SER ARG LEU SER ASP ILE          
SEQRES  10 D  426  PHE ARG LEU ALA SER ILE PHE SER GLY THR GLY ALA ASP          
SEQRES  11 D  426  PRO VAL VAL SER ALA LYS SER ASN HIS CYS LEU ASP ALA          
SEQRES  12 D  426  ALA LYS ALA CYS ASN LEU ASN ASP ASN CYS LYS LYS LEU          
SEQRES  13 D  426  ARG SER SER TYR ILE SER ILE CYS ASN ARG GLU ILE SER          
SEQRES  14 D  426  PRO THR GLU ARG CYS ASN ARG ARG LYS CYS HIS LYS ALA          
SEQRES  15 D  426  LEU ARG GLN PHE PHE ASP ARG VAL PRO SER GLU TYR THR          
SEQRES  16 D  426  TYR ARG MET LEU PHE CYS SER CYS GLN ASP GLN ALA CYS          
SEQRES  17 D  426  ALA GLU ARG ARG ARG GLN THR ILE LEU PRO SER CYS SER          
SEQRES  18 D  426  TYR GLU ASP LYS GLU LYS PRO ASN CYS LEU ASP LEU ARG          
SEQRES  19 D  426  GLY VAL CYS ARG THR ASP HIS LEU CYS ARG SER ARG LEU          
SEQRES  20 D  426  ALA ASP PHE HIS ALA ASN CYS ARG ALA SER TYR GLN THR          
SEQRES  21 D  426  VAL THR SER CYS PRO ALA ASP ASN TYR GLN ALA CYS LEU          
SEQRES  22 D  426  GLY SER TYR ALA GLY MET ILE GLY PHE ASP MET THR PRO          
SEQRES  23 D  426  ASN TYR VAL ASP SER SER PRO THR GLY ILE VAL VAL SER          
SEQRES  24 D  426  PRO TRP CYS SER CYS ARG GLY SER GLY ASN MET GLU GLU          
SEQRES  25 D  426  GLU CYS GLU LYS PHE LEU ARG ASP PHE THR GLU ASN PRO          
SEQRES  26 D  426  CYS LEU ARG ASN ALA ILE GLN ALA PHE GLY ASN GLY THR          
SEQRES  27 D  426  ASP VAL ASN VAL SER PRO LYS GLY PRO SER PHE GLN ALA          
SEQRES  28 D  426  THR GLN ALA PRO ARG VAL GLU LYS THR PRO SER LEU PRO          
SEQRES  29 D  426  ASP ASP LEU SER ASP SER THR SER LEU GLY THR SER VAL          
SEQRES  30 D  426  ILE THR THR CYS THR SER VAL GLN GLU GLN GLY LEU LYS          
SEQRES  31 D  426  ALA ASN ASN SER LYS GLU LEU SER MET CYS PHE THR GLU          
SEQRES  32 D  426  LEU THR THR ASN ILE ILE PRO GLY SER ASN LYS VAL ILE          
SEQRES  33 D  426  LYS PRO ASN SER HIS HIS HIS HIS HIS HIS                      
SEQRES   1 A  102  ALA ARG LEU GLY ALA ARG PRO CYS GLY LEU ARG GLU LEU          
SEQRES   2 A  102  GLU VAL ARG VAL SER GLU LEU GLY LEU GLY TYR ALA SER          
SEQRES   3 A  102  ASP GLU THR VAL LEU PHE ARG TYR CYS ALA GLY ALA CYS          
SEQRES   4 A  102  GLU ALA ALA ALA ARG VAL TYR ASP LEU GLY LEU ARG ARG          
SEQRES   5 A  102  LEU ARG GLN ARG ARG ARG LEU ARG ARG GLU ARG VAL ARG          
SEQRES   6 A  102  ALA GLN PRO CYS CYS ARG PRO THR ALA TYR GLU ASP GLU          
SEQRES   7 A  102  VAL SER PHE LEU ASP ALA HIS SER ARG TYR HIS THR VAL          
SEQRES   8 A  102  HIS GLU LEU SER ALA ARG GLU CYS ALA CYS VAL                  
SEQRES   1 C  426  SER PRO SER SER LEU GLN GLY PRO GLU LEU HIS GLY TRP          
SEQRES   2 C  426  ARG PRO PRO VAL ASP CYS VAL ARG ALA ASN GLU LEU CYS          
SEQRES   3 C  426  ALA ALA GLU SER ASN CYS SER SER ARG TYR ARG THR LEU          
SEQRES   4 C  426  ARG GLN CYS LEU ALA GLY ARG ASP ARG ASN THR MET LEU          
SEQRES   5 C  426  ALA ASN LYS GLU CYS GLN ALA ALA LEU GLU VAL LEU GLN          
SEQRES   6 C  426  GLU SER PRO LEU TYR ASP CYS ARG CYS LYS ARG GLY MET          
SEQRES   7 C  426  LYS LYS GLU LEU GLN CYS LEU GLN ILE TYR TRP SER ILE          
SEQRES   8 C  426  HIS LEU GLY LEU THR GLU GLY GLU GLU PHE TYR GLU ALA          
SEQRES   9 C  426  SER PRO TYR GLU PRO VAL THR SER ARG LEU SER ASP ILE          
SEQRES  10 C  426  PHE ARG LEU ALA SER ILE PHE SER GLY THR GLY ALA ASP          
SEQRES  11 C  426  PRO VAL VAL SER ALA LYS SER ASN HIS CYS LEU ASP ALA          
SEQRES  12 C  426  ALA LYS ALA CYS ASN LEU ASN ASP ASN CYS LYS LYS LEU          
SEQRES  13 C  426  ARG SER SER TYR ILE SER ILE CYS ASN ARG GLU ILE SER          
SEQRES  14 C  426  PRO THR GLU ARG CYS ASN ARG ARG LYS CYS HIS LYS ALA          
SEQRES  15 C  426  LEU ARG GLN PHE PHE ASP ARG VAL PRO SER GLU TYR THR          
SEQRES  16 C  426  TYR ARG MET LEU PHE CYS SER CYS GLN ASP GLN ALA CYS          
SEQRES  17 C  426  ALA GLU ARG ARG ARG GLN THR ILE LEU PRO SER CYS SER          
SEQRES  18 C  426  TYR GLU ASP LYS GLU LYS PRO ASN CYS LEU ASP LEU ARG          
SEQRES  19 C  426  GLY VAL CYS ARG THR ASP HIS LEU CYS ARG SER ARG LEU          
SEQRES  20 C  426  ALA ASP PHE HIS ALA ASN CYS ARG ALA SER TYR GLN THR          
SEQRES  21 C  426  VAL THR SER CYS PRO ALA ASP ASN TYR GLN ALA CYS LEU          
SEQRES  22 C  426  GLY SER TYR ALA GLY MET ILE GLY PHE ASP MET THR PRO          
SEQRES  23 C  426  ASN TYR VAL ASP SER SER PRO THR GLY ILE VAL VAL SER          
SEQRES  24 C  426  PRO TRP CYS SER CYS ARG GLY SER GLY ASN MET GLU GLU          
SEQRES  25 C  426  GLU CYS GLU LYS PHE LEU ARG ASP PHE THR GLU ASN PRO          
SEQRES  26 C  426  CYS LEU ARG ASN ALA ILE GLN ALA PHE GLY ASN GLY THR          
SEQRES  27 C  426  ASP VAL ASN VAL SER PRO LYS GLY PRO SER PHE GLN ALA          
SEQRES  28 C  426  THR GLN ALA PRO ARG VAL GLU LYS THR PRO SER LEU PRO          
SEQRES  29 C  426  ASP ASP LEU SER ASP SER THR SER LEU GLY THR SER VAL          
SEQRES  30 C  426  ILE THR THR CYS THR SER VAL GLN GLU GLN GLY LEU LYS          
SEQRES  31 C  426  ALA ASN ASN SER LYS GLU LEU SER MET CYS PHE THR GLU          
SEQRES  32 C  426  LEU THR THR ASN ILE ILE PRO GLY SER ASN LYS VAL ILE          
SEQRES  33 C  426  LYS PRO ASN SER HIS HIS HIS HIS HIS HIS                      
SEQRES   1 F  613  LEU TYR PHE SER ARG ASP ALA TYR TRP GLU LYS LEU TYR          
SEQRES   2 F  613  VAL ASP GLN ALA ALA GLY THR PRO LEU LEU TYR VAL HIS          
SEQRES   3 F  613  ALA LEU ARG ASP ALA PRO GLU GLU VAL PRO SER PHE ARG          
SEQRES   4 F  613  LEU GLY GLN HIS LEU TYR GLY THR TYR ARG THR ARG LEU          
SEQRES   5 F  613  HIS GLU ASN ASN TRP ILE CYS ILE GLN GLU ASP THR GLY          
SEQRES   6 F  613  LEU LEU TYR LEU ASN ARG SER LEU ASP HIS SER SER TRP          
SEQRES   7 F  613  GLU LYS LEU SER VAL ARG ASN ARG GLY PHE PRO LEU LEU          
SEQRES   8 F  613  THR VAL TYR LEU LYS VAL PHE LEU SER PRO THR SER LEU          
SEQRES   9 F  613  ARG GLU GLY GLU CYS GLN TRP PRO GLY CYS ALA ARG VAL          
SEQRES  10 F  613  TYR PHE SER PHE PHE ASN THR SER PHE PRO ALA CYS SER          
SEQRES  11 F  613  SER LEU LYS PRO ARG GLU LEU CYS PHE PRO GLU THR ARG          
SEQRES  12 F  613  PRO SER PHE ARG ILE ARG GLU ASN ARG PRO PRO GLY THR          
SEQRES  13 F  613  PHE HIS GLN PHE ARG LEU LEU PRO VAL GLN PHE LEU CYS          
SEQRES  14 F  613  PRO ASN ILE SER VAL ALA TYR ARG LEU LEU GLU GLY GLU          
SEQRES  15 F  613  GLY LEU PRO PHE ARG CYS ALA PRO ASP SER LEU GLU VAL          
SEQRES  16 F  613  SER THR ARG TRP ALA LEU ASP ARG GLU GLN ARG GLU LYS          
SEQRES  17 F  613  TYR GLU LEU VAL ALA VAL CYS THR VAL HIS ALA GLY ALA          
SEQRES  18 F  613  ARG GLU GLU VAL VAL MET VAL PRO PHE PRO VAL THR VAL          
SEQRES  19 F  613  TYR ASP GLU ASP ASP SER ALA PRO THR PHE PRO ALA GLY          
SEQRES  20 F  613  VAL ASP THR ALA SER ALA VAL VAL GLU PHE LYS ARG LYS          
SEQRES  21 F  613  GLU ASP THR VAL VAL ALA THR LEU ARG VAL PHE ASP ALA          
SEQRES  22 F  613  ASP VAL VAL PRO ALA SER GLY GLU LEU VAL ARG ARG TYR          
SEQRES  23 F  613  THR SER THR LEU LEU PRO GLY ASP THR TRP ALA GLN GLN          
SEQRES  24 F  613  THR PHE ARG VAL GLU HIS TRP PRO ASN GLU THR SER VAL          
SEQRES  25 F  613  GLN ALA ASN GLY SER PHE VAL ARG ALA THR VAL HIS ASP          
SEQRES  26 F  613  TYR ARG LEU VAL LEU ASN ARG ASN LEU SER ILE SER GLU          
SEQRES  27 F  613  ASN ARG THR MET GLN LEU ALA VAL LEU VAL ASN ASP SER          
SEQRES  28 F  613  ASP PHE GLN GLY PRO GLY ALA GLY VAL LEU LEU LEU HIS          
SEQRES  29 F  613  PHE ASN VAL SER VAL LEU PRO VAL SER LEU HIS LEU PRO          
SEQRES  30 F  613  SER THR TYR SER LEU SER VAL SER ARG ARG ALA ARG ARG          
SEQRES  31 F  613  PHE ALA GLN ILE GLY LYS VAL CYS VAL GLU ASN CYS GLN          
SEQRES  32 F  613  ALA PHE SER GLY ILE ASN VAL GLN TYR LYS LEU HIS SER          
SEQRES  33 F  613  SER GLY ALA ASN CYS SER THR LEU GLY VAL VAL THR SER          
SEQRES  34 F  613  ALA GLU ASP THR SER GLY ILE LEU PHE VAL ASN ASP THR          
SEQRES  35 F  613  LYS ALA LEU ARG ARG PRO LYS CYS ALA GLU LEU HIS TYR          
SEQRES  36 F  613  MET VAL VAL ALA THR ASP GLN GLN THR SER ARG GLN ALA          
SEQRES  37 F  613  GLN ALA GLN LEU LEU VAL THR VAL GLU GLY SER TYR VAL          
SEQRES  38 F  613  ALA GLU GLU ALA GLY CYS PRO LEU SER CYS ALA VAL SER          
SEQRES  39 F  613  LYS ARG ARG LEU GLU CYS GLU GLU CYS GLY GLY LEU GLY          
SEQRES  40 F  613  SER PRO THR GLY ARG CYS GLU TRP ARG GLN GLY ASP GLY          
SEQRES  41 F  613  LYS GLY ILE THR ARG ASN PHE SER THR CYS SER PRO SER          
SEQRES  42 F  613  THR LYS THR CYS PRO ASP GLY HIS CYS ASP VAL VAL GLU          
SEQRES  43 F  613  THR GLN ASP ILE ASN ILE CYS PRO GLN ASP CYS LEU ARG          
SEQRES  44 F  613  GLY SER ILE VAL GLY GLY HIS GLU PRO GLY GLU PRO ARG          
SEQRES  45 F  613  GLY ILE LYS ALA GLY TYR GLY THR CYS ASN CYS PHE PRO          
SEQRES  46 F  613  GLU GLU GLU LYS CYS PHE CYS GLU PRO GLU ASP ILE GLN          
SEQRES  47 F  613  ASP PRO LEU CYS ASP GLU LEU CYS ARG GLU ASN LEU TYR          
SEQRES  48 F  613  PHE GLN                                                      
SEQRES   1 E  613  LEU TYR PHE SER ARG ASP ALA TYR TRP GLU LYS LEU TYR          
SEQRES   2 E  613  VAL ASP GLN ALA ALA GLY THR PRO LEU LEU TYR VAL HIS          
SEQRES   3 E  613  ALA LEU ARG ASP ALA PRO GLU GLU VAL PRO SER PHE ARG          
SEQRES   4 E  613  LEU GLY GLN HIS LEU TYR GLY THR TYR ARG THR ARG LEU          
SEQRES   5 E  613  HIS GLU ASN ASN TRP ILE CYS ILE GLN GLU ASP THR GLY          
SEQRES   6 E  613  LEU LEU TYR LEU ASN ARG SER LEU ASP HIS SER SER TRP          
SEQRES   7 E  613  GLU LYS LEU SER VAL ARG ASN ARG GLY PHE PRO LEU LEU          
SEQRES   8 E  613  THR VAL TYR LEU LYS VAL PHE LEU SER PRO THR SER LEU          
SEQRES   9 E  613  ARG GLU GLY GLU CYS GLN TRP PRO GLY CYS ALA ARG VAL          
SEQRES  10 E  613  TYR PHE SER PHE PHE ASN THR SER PHE PRO ALA CYS SER          
SEQRES  11 E  613  SER LEU LYS PRO ARG GLU LEU CYS PHE PRO GLU THR ARG          
SEQRES  12 E  613  PRO SER PHE ARG ILE ARG GLU ASN ARG PRO PRO GLY THR          
SEQRES  13 E  613  PHE HIS GLN PHE ARG LEU LEU PRO VAL GLN PHE LEU CYS          
SEQRES  14 E  613  PRO ASN ILE SER VAL ALA TYR ARG LEU LEU GLU GLY GLU          
SEQRES  15 E  613  GLY LEU PRO PHE ARG CYS ALA PRO ASP SER LEU GLU VAL          
SEQRES  16 E  613  SER THR ARG TRP ALA LEU ASP ARG GLU GLN ARG GLU LYS          
SEQRES  17 E  613  TYR GLU LEU VAL ALA VAL CYS THR VAL HIS ALA GLY ALA          
SEQRES  18 E  613  ARG GLU GLU VAL VAL MET VAL PRO PHE PRO VAL THR VAL          
SEQRES  19 E  613  TYR ASP GLU ASP ASP SER ALA PRO THR PHE PRO ALA GLY          
SEQRES  20 E  613  VAL ASP THR ALA SER ALA VAL VAL GLU PHE LYS ARG LYS          
SEQRES  21 E  613  GLU ASP THR VAL VAL ALA THR LEU ARG VAL PHE ASP ALA          
SEQRES  22 E  613  ASP VAL VAL PRO ALA SER GLY GLU LEU VAL ARG ARG TYR          
SEQRES  23 E  613  THR SER THR LEU LEU PRO GLY ASP THR TRP ALA GLN GLN          
SEQRES  24 E  613  THR PHE ARG VAL GLU HIS TRP PRO ASN GLU THR SER VAL          
SEQRES  25 E  613  GLN ALA ASN GLY SER PHE VAL ARG ALA THR VAL HIS ASP          
SEQRES  26 E  613  TYR ARG LEU VAL LEU ASN ARG ASN LEU SER ILE SER GLU          
SEQRES  27 E  613  ASN ARG THR MET GLN LEU ALA VAL LEU VAL ASN ASP SER          
SEQRES  28 E  613  ASP PHE GLN GLY PRO GLY ALA GLY VAL LEU LEU LEU HIS          
SEQRES  29 E  613  PHE ASN VAL SER VAL LEU PRO VAL SER LEU HIS LEU PRO          
SEQRES  30 E  613  SER THR TYR SER LEU SER VAL SER ARG ARG ALA ARG ARG          
SEQRES  31 E  613  PHE ALA GLN ILE GLY LYS VAL CYS VAL GLU ASN CYS GLN          
SEQRES  32 E  613  ALA PHE SER GLY ILE ASN VAL GLN TYR LYS LEU HIS SER          
SEQRES  33 E  613  SER GLY ALA ASN CYS SER THR LEU GLY VAL VAL THR SER          
SEQRES  34 E  613  ALA GLU ASP THR SER GLY ILE LEU PHE VAL ASN ASP THR          
SEQRES  35 E  613  LYS ALA LEU ARG ARG PRO LYS CYS ALA GLU LEU HIS TYR          
SEQRES  36 E  613  MET VAL VAL ALA THR ASP GLN GLN THR SER ARG GLN ALA          
SEQRES  37 E  613  GLN ALA GLN LEU LEU VAL THR VAL GLU GLY SER TYR VAL          
SEQRES  38 E  613  ALA GLU GLU ALA GLY CYS PRO LEU SER CYS ALA VAL SER          
SEQRES  39 E  613  LYS ARG ARG LEU GLU CYS GLU GLU CYS GLY GLY LEU GLY          
SEQRES  40 E  613  SER PRO THR GLY ARG CYS GLU TRP ARG GLN GLY ASP GLY          
SEQRES  41 E  613  LYS GLY ILE THR ARG ASN PHE SER THR CYS SER PRO SER          
SEQRES  42 E  613  THR LYS THR CYS PRO ASP GLY HIS CYS ASP VAL VAL GLU          
SEQRES  43 E  613  THR GLN ASP ILE ASN ILE CYS PRO GLN ASP CYS LEU ARG          
SEQRES  44 E  613  GLY SER ILE VAL GLY GLY HIS GLU PRO GLY GLU PRO ARG          
SEQRES  45 E  613  GLY ILE LYS ALA GLY TYR GLY THR CYS ASN CYS PHE PRO          
SEQRES  46 E  613  GLU GLU GLU LYS CYS PHE CYS GLU PRO GLU ASP ILE GLN          
SEQRES  47 E  613  ASP PRO LEU CYS ASP GLU LEU CYS ARG GLU ASN LEU TYR          
SEQRES  48 E  613  PHE GLN                                                      
HELIX    1 AA1 SER B  113  GLY B  116  5                                   4    
HELIX    2 AA2 ARG B  139  ARG B  151  1                                  13    
HELIX    3 AA3 CYS D   40  ALA D   49  1                                  10    
HELIX    4 AA4 GLU D   50  CYS D   63  1                                  14    
HELIX    5 AA5 ALA D   74  GLN D   86  1                                  13    
HELIX    6 AA6 LEU D  103  SER D  111  1                                   9    
HELIX    7 AA7 THR D  132  GLY D  147  1                                  16    
HELIX    8 AA8 ASN D  159  LEU D  170  1                                  12    
HELIX    9 AA9 ASN D  171  ASN D  186  1                                  16    
HELIX   10 AB1 ASN D  196  VAL D  211  1                                  16    
HELIX   11 AB2 PRO D  212  PHE D  221  1                                  10    
HELIX   12 AB3 ASP D  226  GLN D  235  1                                  10    
HELIX   13 AB4 LEU D  238  TYR D  243  1                                   6    
HELIX   14 AB5 ASN D  250  ASP D  261  1                                  12    
HELIX   15 AB6 ASP D  261  ARG D  276  1                                  16    
HELIX   16 AB7 CYS D  285  ASP D  288  5                                   4    
HELIX   17 AB8 ASN D  289  MET D  300  1                                  12    
HELIX   18 AB9 SER D  328  ASN D  330  5                                   3    
HELIX   19 AC1 MET D  331  GLU D  344  1                                  14    
HELIX   20 AC2 ASN D  345  ASN D  357  1                                  13    
HELIX   21 AC3 SER A  113  GLY A  116  5                                   4    
HELIX   22 AC4 ARG A  139  ARG A  151  1                                  13    
HELIX   23 AC5 CYS C   40  ALA C   49  1                                  10    
HELIX   24 AC6 GLU C   50  CYS C   63  1                                  14    
HELIX   25 AC7 ALA C   74  GLN C   86  1                                  13    
HELIX   26 AC8 LEU C  103  SER C  111  1                                   9    
HELIX   27 AC9 THR C  132  GLY C  147  1                                  16    
HELIX   28 AD1 ASN C  159  LEU C  170  1                                  12    
HELIX   29 AD2 ASN C  171  ASN C  186  1                                  16    
HELIX   30 AD3 ASN C  196  VAL C  211  1                                  16    
HELIX   31 AD4 PRO C  212  PHE C  221  1                                  10    
HELIX   32 AD5 ASP C  226  GLN C  235  1                                  10    
HELIX   33 AD6 LEU C  238  TYR C  243  1                                   6    
HELIX   34 AD7 ASN C  250  ARG C  259  1                                  10    
HELIX   35 AD8 ASP C  261  CYS C  275  1                                  15    
HELIX   36 AD9 CYS C  285  ASP C  288  5                                   4    
HELIX   37 AE1 ASN C  289  GLY C  299  1                                  11    
HELIX   38 AE2 SER C  328  ASN C  330  5                                   3    
HELIX   39 AE3 MET C  331  GLU C  344  1                                  14    
HELIX   40 AE4 ASN C  345  ASN C  357  1                                  13    
HELIX   41 AE5 ASP F  102  ARG F  112  1                                  11    
HELIX   42 AE6 ALA F  156  LEU F  160  5                                   5    
HELIX   43 AE7 LYS F  161  PHE F  167  1                                   7    
HELIX   44 AE8 LEU F  190  CYS F  197  1                                   8    
HELIX   45 AE9 ALA F  306  ARG F  312  1                                   7    
HELIX   46 AF1 GLU F  428  PHE F  433  1                                   6    
HELIX   47 AF2 ARG F  474  CYS F  478  5                                   5    
HELIX   48 AF3 ASP E  102  ARG E  112  1                                  11    
HELIX   49 AF4 ALA E  156  LEU E  160  5                                   5    
HELIX   50 AF5 LYS E  161  PHE E  167  1                                   7    
HELIX   51 AF6 LEU E  190  CYS E  197  1                                   8    
HELIX   52 AF7 ALA E  306  ARG E  312  1                                   7    
HELIX   53 AF8 GLU E  428  PHE E  433  1                                   6    
HELIX   54 AF9 ARG E  474  CYS E  478  5                                   5    
SHEET    1 AA1 2 GLY B 104  ARG B 111  0                                        
SHEET    2 AA1 2 THR B 124  ALA B 131 -1  O  TYR B 129   N  ARG B 106           
SHEET    1 AA2 2 CYS B 165  TYR B 170  0                                        
SHEET    2 AA2 2 ALA B 191  CYS B 196 -1  O  ARG B 192   N  ALA B 169           
SHEET    1 AA3 2 VAL B 174  LEU B 177  0                                        
SHEET    2 AA3 2 TYR B 183  VAL B 186 -1  O  VAL B 186   N  VAL B 174           
SHEET    1 AA4 2 ASN D 308  TYR D 309  0                                        
SHEET    2 AA4 2 VAL D 319  SER D 320 -1  O  SER D 320   N  ASN D 308           
SHEET    1 AA5 2 GLY A 104  ARG A 111  0                                        
SHEET    2 AA5 2 THR A 124  ALA A 131 -1  O  TYR A 129   N  ARG A 106           
SHEET    1 AA6 2 CYS A 165  TYR A 170  0                                        
SHEET    2 AA6 2 ALA A 191  CYS A 196 -1  O  ARG A 192   N  ALA A 169           
SHEET    1 AA7 2 VAL A 174  LEU A 177  0                                        
SHEET    2 AA7 2 TYR A 183  VAL A 186 -1  O  VAL A 186   N  VAL A 174           
SHEET    1 AA8 2 ASN C 308  TYR C 309  0                                        
SHEET    2 AA8 2 VAL C 319  SER C 320 -1  O  SER C 320   N  ASN C 308           
SHEET    1 AA9 2 TYR F  30  PHE F  31  0                                        
SHEET    2 AA9 2 ALA F  55  LEU F  56 -1  O  LEU F  56   N  TYR F  30           
SHEET    1 AB1 4 ALA F  35  LEU F  40  0                                        
SHEET    2 AB1 4 CYS F 142  PHE F 149  1  O  TYR F 146   N  TYR F  36           
SHEET    3 AB1 4 THR F 120  PHE F 126 -1  N  VAL F 121   O  PHE F 147           
SHEET    4 AB1 4 ARG F  67  LEU F  68 -1  N  ARG F  67   O  PHE F 126           
SHEET    1 AB2 3 PRO F  49  TYR F  52  0                                        
SHEET    2 AB2 3 LEU F  94  LEU F  97 -1  O  LEU F  95   N  LEU F  51           
SHEET    3 AB2 3 ILE F  86  ILE F  88 -1  N  CYS F  87   O  TYR F  96           
SHEET    1 AB3 2 HIS F  71  GLY F  74  0                                        
SHEET    2 AB3 2 THR F  78  GLU F  82 -1  O  HIS F  81   N  LEU F  72           
SHEET    1 AB4 4 PHE F 174  ILE F 176  0                                        
SHEET    2 AB4 4 GLU F 252  VAL F 262  1  O  THR F 261   N  PHE F 174           
SHEET    3 AB4 4 LYS F 236  VAL F 245 -1  N  ALA F 241   O  VAL F 256           
SHEET    4 AB4 4 VAL F 202  LEU F 207 -1  N  LEU F 207   O  VAL F 240           
SHEET    1 AB5 3 THR F 184  GLN F 187  0                                        
SHEET    2 AB5 3 GLU F 222  THR F 225 -1  O  VAL F 223   N  HIS F 186           
SHEET    3 AB5 3 PHE F 214  ARG F 215 -1  N  ARG F 215   O  SER F 224           
SHEET    1 AB6 2 VAL F 282  VAL F 283  0                                        
SHEET    2 AB6 2 VAL F 376  ASN F 377  1  O  ASN F 377   N  VAL F 282           
SHEET    1 AB7 3 THR F 291  THR F 295  0                                        
SHEET    2 AB7 3 SER F 339  ALA F 342 -1  O  ALA F 342   N  THR F 291           
SHEET    3 AB7 3 PHE F 329  GLU F 332 -1  N  GLU F 332   O  SER F 339           
SHEET    1 AB8 2 HIS F 352  VAL F 357  0                                        
SHEET    2 AB8 2 THR F 369  VAL F 374 -1  O  MET F 370   N  LEU F 356           
SHEET    1 AB9 2 PHE F 419  LYS F 424  0                                        
SHEET    2 AB9 2 ILE F 464  ASN F 468 -1  O  VAL F 467   N  ALA F 420           
SHEET    1 AC1 3 LYS F 441  HIS F 443  0                                        
SHEET    2 AC1 3 GLU F 480  ASP F 489 -1  O  VAL F 486   N  LYS F 441           
SHEET    3 AC1 3 THR F 492  THR F 503 -1  O  LEU F 500   N  TYR F 483           
SHEET    1 AC2 2 TYR E  30  PHE E  31  0                                        
SHEET    2 AC2 2 ALA E  55  LEU E  56 -1  O  LEU E  56   N  TYR E  30           
SHEET    1 AC3 4 ALA E  35  LEU E  40  0                                        
SHEET    2 AC3 4 CYS E 142  PHE E 149  1  O  TYR E 146   N  TYR E  36           
SHEET    3 AC3 4 THR E 120  PHE E 126 -1  N  VAL E 121   O  PHE E 147           
SHEET    4 AC3 4 ARG E  67  LEU E  68 -1  N  ARG E  67   O  PHE E 126           
SHEET    1 AC4 3 PRO E  49  TYR E  52  0                                        
SHEET    2 AC4 3 LEU E  94  LEU E  97 -1  O  LEU E  95   N  LEU E  51           
SHEET    3 AC4 3 ILE E  86  ILE E  88 -1  N  CYS E  87   O  TYR E  96           
SHEET    1 AC5 2 HIS E  71  GLY E  74  0                                        
SHEET    2 AC5 2 THR E  78  GLU E  82 -1  O  HIS E  81   N  LEU E  72           
SHEET    1 AC6 4 PHE E 174  ILE E 176  0                                        
SHEET    2 AC6 4 GLU E 252  VAL E 262  1  O  THR E 261   N  PHE E 174           
SHEET    3 AC6 4 LYS E 236  VAL E 245 -1  N  ALA E 241   O  VAL E 256           
SHEET    4 AC6 4 VAL E 202  LEU E 207 -1  N  LEU E 207   O  VAL E 240           
SHEET    1 AC7 3 THR E 184  GLN E 187  0                                        
SHEET    2 AC7 3 GLU E 222  THR E 225 -1  O  VAL E 223   N  HIS E 186           
SHEET    3 AC7 3 PHE E 214  ARG E 215 -1  N  ARG E 215   O  SER E 224           
SHEET    1 AC8 2 VAL E 282  VAL E 283  0                                        
SHEET    2 AC8 2 VAL E 376  ASN E 377  1  O  ASN E 377   N  VAL E 282           
SHEET    1 AC9 3 THR E 291  THR E 295  0                                        
SHEET    2 AC9 3 SER E 339  ALA E 342 -1  O  ALA E 342   N  THR E 291           
SHEET    3 AC9 3 PHE E 329  GLU E 332 -1  N  GLU E 332   O  SER E 339           
SHEET    1 AD1 2 HIS E 352  VAL E 357  0                                        
SHEET    2 AD1 2 THR E 369  VAL E 374 -1  O  MET E 370   N  LEU E 356           
SHEET    1 AD2 2 PHE E 419  LYS E 424  0                                        
SHEET    2 AD2 2 ILE E 464  ASN E 468 -1  O  VAL E 467   N  ALA E 420           
SHEET    1 AD3 3 LYS E 441  HIS E 443  0                                        
SHEET    2 AD3 3 GLU E 480  ASP E 489 -1  O  VAL E 486   N  LYS E 441           
SHEET    3 AD3 3 THR E 492  THR E 503 -1  O  LEU E 500   N  TYR E 483           
SSBOND   1 CYS B  103    CYS B  165                          1555   1555  2.09  
SSBOND   2 CYS B  130    CYS B  194                          1555   1555  2.04  
SSBOND   3 CYS B  134    CYS B  196                          1555   1555  2.13  
SSBOND   4 CYS B  164    CYS A  164                          1555   1555  2.07  
SSBOND   5 CYS D   40    CYS D   93                          1555   1555  2.00  
SSBOND   6 CYS D   47    CYS D   53                          1555   1555  2.07  
SSBOND   7 CYS D   63    CYS D   78                          1555   1555  2.12  
SSBOND   8 CYS D   95    CYS D  105                          1555   1555  2.22  
SSBOND   9 CYS D  161    CYS D  222                          1555   1555  2.07  
SSBOND  10 CYS D  168    CYS D  174                          1555   1555  2.05  
SSBOND  11 CYS D  185    CYS D  200                          1555   1555  2.04  
SSBOND  12 CYS D  195    CYS D  241                          1555   1555  2.03  
SSBOND  13 CYS D  224    CYS D  229                          1555   1555  2.06  
SSBOND  14 CYS D  251    CYS D  323                          1555   1555  2.03  
SSBOND  15 CYS D  258    CYS D  264                          1555   1555  2.09  
SSBOND  16 CYS D  275    CYS D  293                          1555   1555  2.01  
SSBOND  17 CYS D  285    CYS D  347                          1555   1555  2.06  
SSBOND  18 CYS D  325    CYS D  335                          1555   1555  2.14  
SSBOND  19 CYS A  103    CYS A  165                          1555   1555  2.11  
SSBOND  20 CYS A  130    CYS A  194                          1555   1555  1.98  
SSBOND  21 CYS A  134    CYS A  196                          1555   1555  2.02  
SSBOND  22 CYS C   40    CYS C   93                          1555   1555  2.04  
SSBOND  23 CYS C   47    CYS C   53                          1555   1555  2.08  
SSBOND  24 CYS C   63    CYS C   78                          1555   1555  2.07  
SSBOND  25 CYS C   95    CYS C  105                          1555   1555  2.13  
SSBOND  26 CYS C  161    CYS C  222                          1555   1555  2.05  
SSBOND  27 CYS C  168    CYS C  174                          1555   1555  2.10  
SSBOND  28 CYS C  185    CYS C  200                          1555   1555  2.02  
SSBOND  29 CYS C  195    CYS C  241                          1555   1555  2.03  
SSBOND  30 CYS C  224    CYS C  229                          1555   1555  2.10  
SSBOND  31 CYS C  251    CYS C  323                          1555   1555  2.01  
SSBOND  32 CYS C  258    CYS C  264                          1555   1555  2.08  
SSBOND  33 CYS C  275    CYS C  293                          1555   1555  2.11  
SSBOND  34 CYS C  285    CYS C  347                          1555   1555  2.06  
SSBOND  35 CYS C  325    CYS C  335                          1555   1555  2.09  
SSBOND  36 CYS F  137    CYS F  142                          1555   1555  2.01  
SSBOND  37 CYS F  157    CYS F  197                          1555   1555  2.16  
SSBOND  38 CYS F  166    CYS F  243                          1555   1555  2.00  
SSBOND  39 CYS F  449    CYS F  478                          1555   1555  2.01  
SSBOND  40 CYS E  137    CYS E  142                          1555   1555  2.01  
SSBOND  41 CYS E  157    CYS E  197                          1555   1555  2.16  
SSBOND  42 CYS E  166    CYS E  243                          1555   1555  2.00  
SSBOND  43 CYS E  449    CYS E  478                          1555   1555  2.01  
CISPEP   1 TRP F  139    PRO F  140          0         4.08                     
CISPEP   2 THR F  271    PHE F  272          0       -10.06                     
CISPEP   3 LEU F  319    PRO F  320          0        -1.44                     
CISPEP   4 TRP E  139    PRO E  140          0         4.08                     
CISPEP   5 THR E  271    PHE E  272          0        -8.70                     
CISPEP   6 LEU E  319    PRO E  320          0        -1.34                     
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1           1          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      1.000000  0.000000  0.000000        0.00000                         
SCALE2      0.000000  1.000000  0.000000        0.00000                         
SCALE3      0.000000  0.000000  1.000000        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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