HEADER MEMBRANE PROTEIN 09-OCT-18 6HUO
TITLE CRYOEM STRUCTURE OF HUMAN FULL-LENGTH HETEROMERIC ALPHA1BETA3GAMMA2L
TITLE 2 GABA(A)R IN COMPLEX WITH ALPRAZOLAM (XANAX), GABA AND MEGABODY MB38.
COMPND MOL_ID: 1;
COMPND 2 MOLECULE: GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1,GAMMA-
COMPND 3 AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1;
COMPND 4 CHAIN: A, D;
COMPND 5 SYNONYM: GABA(A) RECEPTOR SUBUNIT ALPHA-1,GABA(A) RECEPTOR SUBUNIT
COMPND 6 ALPHA-1;
COMPND 7 ENGINEERED: YES;
COMPND 8 OTHER_DETAILS: BOVINE GABRA1 SIGNAL PEPTIDE: MKKSPGLSDY LWAWTLFLST
COMPND 9 LTGRSYG FLAG TAG: DYKDDDDK,BOVINE GABRA1 SIGNAL PEPTIDE: MKKSPGLSDY
COMPND 10 LWAWTLFLST LTGRSYG FLAG TAG: DYKDDDDK;
COMPND 11 MOL_ID: 2;
COMPND 12 MOLECULE: GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA-3;
COMPND 13 CHAIN: B, E;
COMPND 14 SYNONYM: GABA(A) RECEPTOR SUBUNIT BETA-3;
COMPND 15 ENGINEERED: YES;
COMPND 16 MOL_ID: 3;
COMPND 17 MOLECULE: GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT GAMMA-2;
COMPND 18 CHAIN: C;
COMPND 19 SYNONYM: GABA(A) RECEPTOR SUBUNIT GAMMA-2;
COMPND 20 ENGINEERED: YES;
COMPND 21 OTHER_DETAILS: LINKER SEQUENCE: GGSGGSGGSGK 1D4 TAG: TETSQVAPA;
COMPND 22 MOL_ID: 4;
COMPND 23 MOLECULE: MEGABODY MB38;
COMPND 24 CHAIN: G;
COMPND 25 ENGINEERED: YES;
COMPND 26 OTHER_DETAILS: 6HIS TAG: HHHHHH EPEA TAG: EPEA
SOURCE MOL_ID: 1;
SOURCE 2 ORGANISM_SCIENTIFIC: BOS TAURUS, HOMO SAPIENS;
SOURCE 3 ORGANISM_COMMON: BOVINE, HUMAN;
SOURCE 4 ORGANISM_TAXID: 9913, 9606;
SOURCE 5 GENE: GABRA1;
SOURCE 6 EXPRESSION_SYSTEM: HOMO SAPIENS;
SOURCE 7 EXPRESSION_SYSTEM_TAXID: 9606;
SOURCE 8 EXPRESSION_SYSTEM_CELL_LINE: HEK293S;
SOURCE 9 EXPRESSION_SYSTEM_ATCC_NUMBER: 3022;
SOURCE 10 MOL_ID: 2;
SOURCE 11 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 12 ORGANISM_COMMON: HUMAN;
SOURCE 13 ORGANISM_TAXID: 9606;
SOURCE 14 GENE: GABRB3;
SOURCE 15 EXPRESSION_SYSTEM: HOMO SAPIENS;
SOURCE 16 EXPRESSION_SYSTEM_TAXID: 9606;
SOURCE 17 EXPRESSION_SYSTEM_CELL_LINE: HEK293S;
SOURCE 18 EXPRESSION_SYSTEM_ATCC_NUMBER: 3022;
SOURCE 19 MOL_ID: 3;
SOURCE 20 ORGANISM_SCIENTIFIC: HOMO SAPIENS;
SOURCE 21 ORGANISM_COMMON: HUMAN;
SOURCE 22 ORGANISM_TAXID: 9606;
SOURCE 23 GENE: GABRG2;
SOURCE 24 EXPRESSION_SYSTEM: HOMO SAPIENS;
SOURCE 25 EXPRESSION_SYSTEM_TAXID: 9606;
SOURCE 26 EXPRESSION_SYSTEM_CELL_LINE: HEK293S;
SOURCE 27 EXPRESSION_SYSTEM_ATCC_NUMBER: 3022;
SOURCE 28 MOL_ID: 4;
SOURCE 29 ORGANISM_SCIENTIFIC: LAMA GLAMA;
SOURCE 30 ORGANISM_TAXID: 9844;
SOURCE 31 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE 32 EXPRESSION_SYSTEM_TAXID: 562;
SOURCE 33 EXPRESSION_SYSTEM_ATCC_NUMBER: 3022
KEYWDS GABAAR, MEMBRANE PROTEIN, PLGIC, CYS-LOOP RECEPTOR
EXPDTA ELECTRON MICROSCOPY
AUTHOR S.MASIULIS,R.DESAI,T.UCHANSKI,I.SERNA MARTIN,D.LAVERTY,D.KARIA,
AUTHOR 2 T.MALINAUSKAS,Z.JASENKO,E.PARDON,A.KOTECHA,J.STEYAERT,K.W.MILLER,
AUTHOR 3 A.R.ARICESCU
REVDAT 7 15-NOV-23 6HUO 1 ATOM
REVDAT 6 30-MAR-22 6HUO 1 REMARK
REVDAT 5 29-JUL-20 6HUO 1 COMPND REMARK HETNAM HETSYN
REVDAT 5 2 1 LINK SITE ATOM
REVDAT 4 18-DEC-19 6HUO 1 SCALE
REVDAT 3 23-JAN-19 6HUO 1 JRNL
REVDAT 2 16-JAN-19 6HUO 1 JRNL
REVDAT 1 02-JAN-19 6HUO 0
JRNL AUTH S.MASIULIS,R.DESAI,T.UCHANSKI,I.SERNA MARTIN,D.LAVERTY,
JRNL AUTH 2 D.KARIA,T.MALINAUSKAS,J.ZIVANOV,E.PARDON,A.KOTECHA,
JRNL AUTH 3 J.STEYAERT,K.W.MILLER,A.R.ARICESCU
JRNL TITL GABAARECEPTOR SIGNALLING MECHANISMS REVEALED BY STRUCTURAL
JRNL TITL 2 PHARMACOLOGY.
JRNL REF NATURE V. 565 454 2019
JRNL REFN ISSN 0028-0836
JRNL PMID 30602790
JRNL DOI 10.1038/S41586-018-0832-5
REMARK 2
REMARK 2 RESOLUTION. 3.26 ANGSTROMS.
REMARK 3
REMARK 3 REFINEMENT.
REMARK 3 SOFTWARE PACKAGES : EPU, GCTF, UCSF CHIMERA, RELION,
REMARK 3 RELION, RELION, RELION, PHENIX
REMARK 3 RECONSTRUCTION SCHEMA : NULL
REMARK 3
REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT
REMARK 3 PDB ENTRY : NULL
REMARK 3 REFINEMENT SPACE : REAL
REMARK 3 REFINEMENT PROTOCOL : FLEXIBLE FIT
REMARK 3 REFINEMENT TARGET : NULL
REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL
REMARK 3
REMARK 3 FITTING PROCEDURE : NULL
REMARK 3
REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS
REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL
REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL
REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 3.260
REMARK 3 NUMBER OF PARTICLES : 39050
REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE
REMARK 3 CORRECTION
REMARK 3
REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL
REMARK 3
REMARK 3 OTHER DETAILS: NULL
REMARK 4
REMARK 4 6HUO COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 09-OCT-18.
REMARK 100 THE DEPOSITION ID IS D_1200012332.
REMARK 245
REMARK 245 EXPERIMENTAL DETAILS
REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE
REMARK 245 SPECIMEN TYPE : NULL
REMARK 245
REMARK 245 ELECTRON MICROSCOPE SAMPLE
REMARK 245 SAMPLE TYPE : PARTICLE
REMARK 245 PARTICLE TYPE : POINT
REMARK 245 NAME OF SAMPLE : CRYOEM STRUCTURE OF HUMAN FULL
REMARK 245 -LENGTH HETEROMERIC
REMARK 245 ALPHA1BETA3GAMMA2L GABA(A)R IN
REMARK 245 COMPLEX WITH ALPRAZOLAM (XANAX),
REMARK 245 GABA AND MEGABODY MB38.;
REMARK 245 HETEROMERIC ALPHA1BETA3GAMMA2L
REMARK 245 GABA(A)R; MEGABODY MB38
REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : 0.10
REMARK 245 SAMPLE SUPPORT DETAILS : NULL
REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL
REMARK 245 SAMPLE BUFFER : NULL
REMARK 245 PH : 7.60
REMARK 245 SAMPLE DETAILS : NULL
REMARK 245
REMARK 245 DATA ACQUISITION
REMARK 245 DATE OF EXPERIMENT : NULL
REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : NULL
REMARK 245 TEMPERATURE (KELVIN) : NULL
REMARK 245 MICROSCOPE MODEL : FEI TITAN KRIOS
REMARK 245 DETECTOR TYPE : FEI FALCON III (4K X 4K)
REMARK 245 MINIMUM DEFOCUS (NM) : 500.00
REMARK 245 MAXIMUM DEFOCUS (NM) : 700.00
REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL
REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL
REMARK 245 NOMINAL CS : 2.70
REMARK 245 IMAGING MODE : BRIGHT FIELD
REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 3000.00
REMARK 245 ILLUMINATION MODE : FLOOD BEAM
REMARK 245 NOMINAL MAGNIFICATION : 75000
REMARK 245 CALIBRATED MAGNIFICATION : NULL
REMARK 245 SOURCE : FIELD EMISSION GUN
REMARK 245 ACCELERATION VOLTAGE (KV) : 300
REMARK 245 IMAGING DETAILS : NULL
REMARK 247
REMARK 247 ELECTRON MICROSCOPY
REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON
REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE
REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES
REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION
REMARK 247 OF THE STRUCTURE FACTORS.
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: HEXAMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 41240 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 71840 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -75.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E, G, F, H, I, J,
REMARK 350 AND CHAINS: K, L, M
REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000
REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000
REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465 M RES C SSSEQI
REMARK 465 MET A -34
REMARK 465 LYS A -33
REMARK 465 LYS A -32
REMARK 465 SER A -31
REMARK 465 PRO A -30
REMARK 465 GLY A -29
REMARK 465 LEU A -28
REMARK 465 SER A -27
REMARK 465 ASP A -26
REMARK 465 TYR A -25
REMARK 465 LEU A -24
REMARK 465 TRP A -23
REMARK 465 ALA A -22
REMARK 465 TRP A -21
REMARK 465 THR A -20
REMARK 465 LEU A -19
REMARK 465 PHE A -18
REMARK 465 LEU A -17
REMARK 465 SER A -16
REMARK 465 THR A -15
REMARK 465 LEU A -14
REMARK 465 THR A -13
REMARK 465 GLY A -12
REMARK 465 ARG A -11
REMARK 465 SER A -10
REMARK 465 TYR A -9
REMARK 465 GLY A -8
REMARK 465 ASP A -7
REMARK 465 TYR A -6
REMARK 465 LYS A -5
REMARK 465 ASP A -4
REMARK 465 ASP A -3
REMARK 465 ASP A -2
REMARK 465 ASP A -1
REMARK 465 LYS A 0
REMARK 465 GLN A 1
REMARK 465 PRO A 2
REMARK 465 SER A 3
REMARK 465 LEU A 4
REMARK 465 GLN A 5
REMARK 465 ASP A 6
REMARK 465 GLU A 7
REMARK 465 LEU A 8
REMARK 465 LYS A 9
REMARK 465 ASP A 10
REMARK 465 ASN A 11
REMARK 465 THR A 12
REMARK 465 VAL A 322
REMARK 465 VAL A 323
REMARK 465 PRO A 324
REMARK 465 GLU A 325
REMARK 465 LYS A 326
REMARK 465 PRO A 327
REMARK 465 LYS A 328
REMARK 465 LYS A 329
REMARK 465 VAL A 330
REMARK 465 LYS A 331
REMARK 465 ASP A 332
REMARK 465 PRO A 333
REMARK 465 LEU A 334
REMARK 465 ILE A 335
REMARK 465 LYS A 336
REMARK 465 LYS A 337
REMARK 465 ASN A 338
REMARK 465 ASN A 339
REMARK 465 THR A 340
REMARK 465 TYR A 341
REMARK 465 ALA A 342
REMARK 465 PRO A 343
REMARK 465 THR A 344
REMARK 465 ALA A 345
REMARK 465 THR A 346
REMARK 465 SER A 347
REMARK 465 TYR A 348
REMARK 465 THR A 349
REMARK 465 PRO A 350
REMARK 465 ASN A 351
REMARK 465 LEU A 352
REMARK 465 ALA A 353
REMARK 465 ARG A 354
REMARK 465 GLY A 355
REMARK 465 ASP A 356
REMARK 465 PRO A 357
REMARK 465 GLY A 358
REMARK 465 LEU A 359
REMARK 465 ALA A 360
REMARK 465 THR A 361
REMARK 465 ILE A 362
REMARK 465 ALA A 363
REMARK 465 LYS A 364
REMARK 465 SER A 365
REMARK 465 ALA A 366
REMARK 465 THR A 367
REMARK 465 ILE A 368
REMARK 465 GLU A 369
REMARK 465 PRO A 370
REMARK 465 LYS A 371
REMARK 465 GLU A 372
REMARK 465 VAL A 373
REMARK 465 LYS A 374
REMARK 465 PRO A 375
REMARK 465 GLU A 376
REMARK 465 THR A 377
REMARK 465 LYS A 378
REMARK 465 PRO A 379
REMARK 465 PRO A 380
REMARK 465 GLU A 381
REMARK 465 PRO A 382
REMARK 465 LYS A 383
REMARK 465 GLU A 419
REMARK 465 PRO A 420
REMARK 465 GLN A 421
REMARK 465 LEU A 422
REMARK 465 LYS A 423
REMARK 465 ALA A 424
REMARK 465 PRO A 425
REMARK 465 THR A 426
REMARK 465 PRO A 427
REMARK 465 HIS A 428
REMARK 465 GLN A 429
REMARK 465 MET B -24
REMARK 465 CYS B -23
REMARK 465 SER B -22
REMARK 465 GLY B -21
REMARK 465 LEU B -20
REMARK 465 LEU B -19
REMARK 465 GLU B -18
REMARK 465 LEU B -17
REMARK 465 LEU B -16
REMARK 465 LEU B -15
REMARK 465 PRO B -14
REMARK 465 ILE B -13
REMARK 465 TRP B -12
REMARK 465 LEU B -11
REMARK 465 SER B -10
REMARK 465 TRP B -9
REMARK 465 THR B -8
REMARK 465 LEU B -7
REMARK 465 GLY B -6
REMARK 465 THR B -5
REMARK 465 ARG B -4
REMARK 465 GLY B -3
REMARK 465 SER B -2
REMARK 465 GLU B -1
REMARK 465 PRO B 0
REMARK 465 ARG B 1
REMARK 465 SER B 2
REMARK 465 VAL B 3
REMARK 465 ASN B 4
REMARK 465 ASP B 5
REMARK 465 PRO B 6
REMARK 465 GLY B 7
REMARK 465 GLN B 314
REMARK 465 LYS B 315
REMARK 465 LYS B 316
REMARK 465 LEU B 317
REMARK 465 ALA B 318
REMARK 465 GLU B 319
REMARK 465 LYS B 320
REMARK 465 THR B 321
REMARK 465 ALA B 322
REMARK 465 LYS B 323
REMARK 465 ALA B 324
REMARK 465 LYS B 325
REMARK 465 ASN B 326
REMARK 465 ASP B 327
REMARK 465 ARG B 328
REMARK 465 SER B 329
REMARK 465 LYS B 330
REMARK 465 SER B 331
REMARK 465 GLU B 332
REMARK 465 SER B 333
REMARK 465 ASN B 334
REMARK 465 ARG B 335
REMARK 465 VAL B 336
REMARK 465 ASP B 337
REMARK 465 ALA B 338
REMARK 465 HIS B 339
REMARK 465 GLY B 340
REMARK 465 ASN B 341
REMARK 465 ILE B 342
REMARK 465 LEU B 343
REMARK 465 LEU B 344
REMARK 465 THR B 345
REMARK 465 SER B 346
REMARK 465 LEU B 347
REMARK 465 GLU B 348
REMARK 465 VAL B 349
REMARK 465 HIS B 350
REMARK 465 ASN B 351
REMARK 465 GLU B 352
REMARK 465 MET B 353
REMARK 465 ASN B 354
REMARK 465 GLU B 355
REMARK 465 VAL B 356
REMARK 465 SER B 357
REMARK 465 GLY B 358
REMARK 465 GLY B 359
REMARK 465 ILE B 360
REMARK 465 GLY B 361
REMARK 465 ASP B 362
REMARK 465 THR B 363
REMARK 465 ARG B 364
REMARK 465 ASN B 365
REMARK 465 SER B 366
REMARK 465 ALA B 367
REMARK 465 ILE B 368
REMARK 465 SER B 369
REMARK 465 PHE B 370
REMARK 465 ASP B 371
REMARK 465 ASN B 372
REMARK 465 SER B 373
REMARK 465 GLY B 374
REMARK 465 ILE B 375
REMARK 465 GLN B 376
REMARK 465 TYR B 377
REMARK 465 ARG B 378
REMARK 465 LYS B 379
REMARK 465 GLN B 380
REMARK 465 SER B 381
REMARK 465 MET B 382
REMARK 465 PRO B 383
REMARK 465 ARG B 384
REMARK 465 GLU B 385
REMARK 465 GLY B 386
REMARK 465 HIS B 387
REMARK 465 GLY B 388
REMARK 465 ARG B 389
REMARK 465 PHE B 390
REMARK 465 LEU B 391
REMARK 465 GLY B 392
REMARK 465 ASP B 393
REMARK 465 ARG B 394
REMARK 465 SER B 395
REMARK 465 LEU B 396
REMARK 465 PRO B 397
REMARK 465 HIS B 398
REMARK 465 LYS B 399
REMARK 465 LYS B 400
REMARK 465 THR B 401
REMARK 465 HIS B 402
REMARK 465 LEU B 403
REMARK 465 ARG B 404
REMARK 465 ARG B 405
REMARK 465 ARG B 406
REMARK 465 SER B 407
REMARK 465 SER B 408
REMARK 465 GLN B 409
REMARK 465 LEU B 410
REMARK 465 LYS B 411
REMARK 465 ILE B 412
REMARK 465 LYS B 413
REMARK 465 ILE B 414
REMARK 465 PRO B 415
REMARK 465 ASP B 416
REMARK 465 LEU B 417
REMARK 465 ASN B 448
REMARK 465 MET C -38
REMARK 465 SER C -37
REMARK 465 SER C -36
REMARK 465 PRO C -35
REMARK 465 ASN C -34
REMARK 465 ILE C -33
REMARK 465 TRP C -32
REMARK 465 SER C -31
REMARK 465 THR C -30
REMARK 465 GLY C -29
REMARK 465 SER C -28
REMARK 465 SER C -27
REMARK 465 VAL C -26
REMARK 465 TYR C -25
REMARK 465 SER C -24
REMARK 465 THR C -23
REMARK 465 PRO C -22
REMARK 465 VAL C -21
REMARK 465 PHE C -20
REMARK 465 SER C -19
REMARK 465 GLN C -18
REMARK 465 LYS C -17
REMARK 465 MET C -16
REMARK 465 THR C -15
REMARK 465 VAL C -14
REMARK 465 TRP C -13
REMARK 465 ILE C -12
REMARK 465 LEU C -11
REMARK 465 LEU C -10
REMARK 465 LEU C -9
REMARK 465 LEU C -8
REMARK 465 SER C -7
REMARK 465 LEU C -6
REMARK 465 TYR C -5
REMARK 465 PRO C -4
REMARK 465 GLY C -3
REMARK 465 PHE C -2
REMARK 465 THR C -1
REMARK 465 SER C 0
REMARK 465 GLN C 1
REMARK 465 LYS C 2
REMARK 465 SER C 3
REMARK 465 ASP C 4
REMARK 465 ASP C 5
REMARK 465 ASP C 6
REMARK 465 TYR C 7
REMARK 465 GLU C 8
REMARK 465 ASP C 9
REMARK 465 TYR C 10
REMARK 465 ALA C 11
REMARK 465 SER C 12
REMARK 465 ASN C 13
REMARK 465 LYS C 14
REMARK 465 THR C 15
REMARK 465 TRP C 16
REMARK 465 VAL C 17
REMARK 465 LEU C 18
REMARK 465 THR C 19
REMARK 465 PRO C 20
REMARK 465 LYS C 21
REMARK 465 VAL C 22
REMARK 465 PRO C 23
REMARK 465 GLU C 24
REMARK 465 GLY C 25
REMARK 465 LYS C 325
REMARK 465 PRO C 326
REMARK 465 SER C 327
REMARK 465 LYS C 328
REMARK 465 ASP C 329
REMARK 465 LYS C 330
REMARK 465 ASP C 331
REMARK 465 LYS C 332
REMARK 465 LYS C 333
REMARK 465 LYS C 334
REMARK 465 LYS C 335
REMARK 465 ASN C 336
REMARK 465 PRO C 337
REMARK 465 LEU C 338
REMARK 465 LEU C 339
REMARK 465 ARG C 340
REMARK 465 MET C 341
REMARK 465 PHE C 342
REMARK 465 SER C 343
REMARK 465 PHE C 344
REMARK 465 LYS C 345
REMARK 465 ALA C 346
REMARK 465 PRO C 347
REMARK 465 THR C 348
REMARK 465 ILE C 349
REMARK 465 ASP C 350
REMARK 465 ILE C 351
REMARK 465 ARG C 352
REMARK 465 PRO C 353
REMARK 465 ARG C 354
REMARK 465 SER C 355
REMARK 465 ALA C 356
REMARK 465 THR C 357
REMARK 465 ILE C 358
REMARK 465 GLN C 359
REMARK 465 MET C 360
REMARK 465 ASN C 361
REMARK 465 ASN C 362
REMARK 465 ALA C 363
REMARK 465 THR C 364
REMARK 465 HIS C 365
REMARK 465 LEU C 366
REMARK 465 GLN C 367
REMARK 465 GLU C 368
REMARK 465 ARG C 369
REMARK 465 ASP C 370
REMARK 465 GLU C 371
REMARK 465 GLU C 372
REMARK 465 TYR C 373
REMARK 465 GLY C 374
REMARK 465 TYR C 375
REMARK 465 GLU C 376
REMARK 465 CYS C 377
REMARK 465 LEU C 378
REMARK 465 ASP C 379
REMARK 465 GLY C 380
REMARK 465 LYS C 381
REMARK 465 ASP C 382
REMARK 465 CYS C 383
REMARK 465 ALA C 384
REMARK 465 SER C 385
REMARK 465 PHE C 386
REMARK 465 PHE C 387
REMARK 465 CYS C 388
REMARK 465 CYS C 389
REMARK 465 PHE C 390
REMARK 465 GLU C 391
REMARK 465 ASP C 392
REMARK 465 CYS C 393
REMARK 465 ARG C 394
REMARK 465 THR C 395
REMARK 465 GLY C 396
REMARK 465 ALA C 397
REMARK 465 TRP C 398
REMARK 465 ARG C 399
REMARK 465 HIS C 400
REMARK 465 GLY C 401
REMARK 465 ARG C 402
REMARK 465 ILE C 403
REMARK 465 HIS C 404
REMARK 465 ILE C 405
REMARK 465 GLY C 437
REMARK 465 GLY C 438
REMARK 465 SER C 439
REMARK 465 GLY C 440
REMARK 465 GLY C 441
REMARK 465 SER C 442
REMARK 465 GLY C 443
REMARK 465 GLY C 444
REMARK 465 SER C 445
REMARK 465 GLY C 446
REMARK 465 LYS C 447
REMARK 465 THR C 448
REMARK 465 GLU C 449
REMARK 465 THR C 450
REMARK 465 SER C 451
REMARK 465 GLN C 452
REMARK 465 VAL C 453
REMARK 465 ALA C 454
REMARK 465 PRO C 455
REMARK 465 ALA C 456
REMARK 465 MET D -34
REMARK 465 LYS D -33
REMARK 465 LYS D -32
REMARK 465 SER D -31
REMARK 465 PRO D -30
REMARK 465 GLY D -29
REMARK 465 LEU D -28
REMARK 465 SER D -27
REMARK 465 ASP D -26
REMARK 465 TYR D -25
REMARK 465 LEU D -24
REMARK 465 TRP D -23
REMARK 465 ALA D -22
REMARK 465 TRP D -21
REMARK 465 THR D -20
REMARK 465 LEU D -19
REMARK 465 PHE D -18
REMARK 465 LEU D -17
REMARK 465 SER D -16
REMARK 465 THR D -15
REMARK 465 LEU D -14
REMARK 465 THR D -13
REMARK 465 GLY D -12
REMARK 465 ARG D -11
REMARK 465 SER D -10
REMARK 465 TYR D -9
REMARK 465 GLY D -8
REMARK 465 ASP D -7
REMARK 465 TYR D -6
REMARK 465 LYS D -5
REMARK 465 ASP D -4
REMARK 465 ASP D -3
REMARK 465 ASP D -2
REMARK 465 ASP D -1
REMARK 465 LYS D 0
REMARK 465 GLN D 1
REMARK 465 PRO D 2
REMARK 465 SER D 3
REMARK 465 LEU D 4
REMARK 465 GLN D 5
REMARK 465 ASP D 6
REMARK 465 GLU D 7
REMARK 465 LEU D 8
REMARK 465 LYS D 9
REMARK 465 ASP D 10
REMARK 465 ASN D 11
REMARK 465 THR D 12
REMARK 465 SER D 321
REMARK 465 VAL D 322
REMARK 465 VAL D 323
REMARK 465 PRO D 324
REMARK 465 GLU D 325
REMARK 465 LYS D 326
REMARK 465 PRO D 327
REMARK 465 LYS D 328
REMARK 465 LYS D 329
REMARK 465 VAL D 330
REMARK 465 LYS D 331
REMARK 465 ASP D 332
REMARK 465 PRO D 333
REMARK 465 LEU D 334
REMARK 465 ILE D 335
REMARK 465 LYS D 336
REMARK 465 LYS D 337
REMARK 465 ASN D 338
REMARK 465 ASN D 339
REMARK 465 THR D 340
REMARK 465 TYR D 341
REMARK 465 ALA D 342
REMARK 465 PRO D 343
REMARK 465 THR D 344
REMARK 465 ALA D 345
REMARK 465 THR D 346
REMARK 465 SER D 347
REMARK 465 TYR D 348
REMARK 465 THR D 349
REMARK 465 PRO D 350
REMARK 465 ASN D 351
REMARK 465 LEU D 352
REMARK 465 ALA D 353
REMARK 465 ARG D 354
REMARK 465 GLY D 355
REMARK 465 ASP D 356
REMARK 465 PRO D 357
REMARK 465 GLY D 358
REMARK 465 LEU D 359
REMARK 465 ALA D 360
REMARK 465 THR D 361
REMARK 465 ILE D 362
REMARK 465 ALA D 363
REMARK 465 LYS D 364
REMARK 465 SER D 365
REMARK 465 ALA D 366
REMARK 465 THR D 367
REMARK 465 ILE D 368
REMARK 465 GLU D 369
REMARK 465 PRO D 370
REMARK 465 LYS D 371
REMARK 465 GLU D 372
REMARK 465 VAL D 373
REMARK 465 LYS D 374
REMARK 465 PRO D 375
REMARK 465 GLU D 376
REMARK 465 THR D 377
REMARK 465 LYS D 378
REMARK 465 PRO D 379
REMARK 465 PRO D 380
REMARK 465 GLU D 381
REMARK 465 PRO D 382
REMARK 465 LYS D 383
REMARK 465 GLU D 419
REMARK 465 PRO D 420
REMARK 465 GLN D 421
REMARK 465 LEU D 422
REMARK 465 LYS D 423
REMARK 465 ALA D 424
REMARK 465 PRO D 425
REMARK 465 THR D 426
REMARK 465 PRO D 427
REMARK 465 HIS D 428
REMARK 465 GLN D 429
REMARK 465 MET E -24
REMARK 465 CYS E -23
REMARK 465 SER E -22
REMARK 465 GLY E -21
REMARK 465 LEU E -20
REMARK 465 LEU E -19
REMARK 465 GLU E -18
REMARK 465 LEU E -17
REMARK 465 LEU E -16
REMARK 465 LEU E -15
REMARK 465 PRO E -14
REMARK 465 ILE E -13
REMARK 465 TRP E -12
REMARK 465 LEU E -11
REMARK 465 SER E -10
REMARK 465 TRP E -9
REMARK 465 THR E -8
REMARK 465 LEU E -7
REMARK 465 GLY E -6
REMARK 465 THR E -5
REMARK 465 ARG E -4
REMARK 465 GLY E -3
REMARK 465 SER E -2
REMARK 465 GLU E -1
REMARK 465 PRO E 0
REMARK 465 ARG E 1
REMARK 465 SER E 2
REMARK 465 VAL E 3
REMARK 465 ASN E 4
REMARK 465 ASP E 5
REMARK 465 PRO E 6
REMARK 465 GLY E 7
REMARK 465 ARG E 313
REMARK 465 GLN E 314
REMARK 465 LYS E 315
REMARK 465 LYS E 316
REMARK 465 LEU E 317
REMARK 465 ALA E 318
REMARK 465 GLU E 319
REMARK 465 LYS E 320
REMARK 465 THR E 321
REMARK 465 ALA E 322
REMARK 465 LYS E 323
REMARK 465 ALA E 324
REMARK 465 LYS E 325
REMARK 465 ASN E 326
REMARK 465 ASP E 327
REMARK 465 ARG E 328
REMARK 465 SER E 329
REMARK 465 LYS E 330
REMARK 465 SER E 331
REMARK 465 GLU E 332
REMARK 465 SER E 333
REMARK 465 ASN E 334
REMARK 465 ARG E 335
REMARK 465 VAL E 336
REMARK 465 ASP E 337
REMARK 465 ALA E 338
REMARK 465 HIS E 339
REMARK 465 GLY E 340
REMARK 465 ASN E 341
REMARK 465 ILE E 342
REMARK 465 LEU E 343
REMARK 465 LEU E 344
REMARK 465 THR E 345
REMARK 465 SER E 346
REMARK 465 LEU E 347
REMARK 465 GLU E 348
REMARK 465 VAL E 349
REMARK 465 HIS E 350
REMARK 465 ASN E 351
REMARK 465 GLU E 352
REMARK 465 MET E 353
REMARK 465 ASN E 354
REMARK 465 GLU E 355
REMARK 465 VAL E 356
REMARK 465 SER E 357
REMARK 465 GLY E 358
REMARK 465 GLY E 359
REMARK 465 ILE E 360
REMARK 465 GLY E 361
REMARK 465 ASP E 362
REMARK 465 THR E 363
REMARK 465 ARG E 364
REMARK 465 ASN E 365
REMARK 465 SER E 366
REMARK 465 ALA E 367
REMARK 465 ILE E 368
REMARK 465 SER E 369
REMARK 465 PHE E 370
REMARK 465 ASP E 371
REMARK 465 ASN E 372
REMARK 465 SER E 373
REMARK 465 GLY E 374
REMARK 465 ILE E 375
REMARK 465 GLN E 376
REMARK 465 TYR E 377
REMARK 465 ARG E 378
REMARK 465 LYS E 379
REMARK 465 GLN E 380
REMARK 465 SER E 381
REMARK 465 MET E 382
REMARK 465 PRO E 383
REMARK 465 ARG E 384
REMARK 465 GLU E 385
REMARK 465 GLY E 386
REMARK 465 HIS E 387
REMARK 465 GLY E 388
REMARK 465 ARG E 389
REMARK 465 PHE E 390
REMARK 465 LEU E 391
REMARK 465 GLY E 392
REMARK 465 ASP E 393
REMARK 465 ARG E 394
REMARK 465 SER E 395
REMARK 465 LEU E 396
REMARK 465 PRO E 397
REMARK 465 HIS E 398
REMARK 465 LYS E 399
REMARK 465 LYS E 400
REMARK 465 THR E 401
REMARK 465 HIS E 402
REMARK 465 LEU E 403
REMARK 465 ARG E 404
REMARK 465 ARG E 405
REMARK 465 ARG E 406
REMARK 465 SER E 407
REMARK 465 SER E 408
REMARK 465 GLN E 409
REMARK 465 LEU E 410
REMARK 465 LYS E 411
REMARK 465 ILE E 412
REMARK 465 LYS E 413
REMARK 465 ILE E 414
REMARK 465 PRO E 415
REMARK 465 ASP E 416
REMARK 465 LEU E 417
REMARK 465 THR E 418
REMARK 465 ASN E 448
REMARK 465 THR G 14
REMARK 465 LYS G 15
REMARK 465 THR G 16
REMARK 465 THR G 17
REMARK 465 THR G 18
REMARK 465 SER G 19
REMARK 465 VAL G 20
REMARK 465 ILE G 21
REMARK 465 ASP G 22
REMARK 465 THR G 23
REMARK 465 THR G 24
REMARK 465 ASN G 25
REMARK 465 ASP G 26
REMARK 465 ALA G 27
REMARK 465 GLN G 28
REMARK 465 ASN G 29
REMARK 465 LEU G 30
REMARK 465 LEU G 31
REMARK 465 THR G 32
REMARK 465 GLN G 33
REMARK 465 ALA G 34
REMARK 465 GLN G 35
REMARK 465 THR G 36
REMARK 465 ILE G 37
REMARK 465 VAL G 38
REMARK 465 ASN G 39
REMARK 465 THR G 40
REMARK 465 LEU G 41
REMARK 465 LYS G 42
REMARK 465 ASP G 43
REMARK 465 TYR G 44
REMARK 465 CYS G 45
REMARK 465 PRO G 46
REMARK 465 ILE G 47
REMARK 465 LEU G 48
REMARK 465 ILE G 49
REMARK 465 ALA G 50
REMARK 465 LYS G 51
REMARK 465 SER G 52
REMARK 465 SER G 53
REMARK 465 SER G 54
REMARK 465 SER G 55
REMARK 465 ASN G 56
REMARK 465 GLY G 57
REMARK 465 GLY G 58
REMARK 465 THR G 59
REMARK 465 ASN G 60
REMARK 465 ASN G 61
REMARK 465 ALA G 62
REMARK 465 ASN G 63
REMARK 465 THR G 64
REMARK 465 PRO G 65
REMARK 465 SER G 66
REMARK 465 TRP G 67
REMARK 465 GLN G 68
REMARK 465 THR G 69
REMARK 465 ALA G 70
REMARK 465 GLY G 71
REMARK 465 GLY G 72
REMARK 465 GLY G 73
REMARK 465 LYS G 74
REMARK 465 ASN G 75
REMARK 465 SER G 76
REMARK 465 CYS G 77
REMARK 465 ALA G 78
REMARK 465 THR G 79
REMARK 465 PHE G 80
REMARK 465 GLY G 81
REMARK 465 ALA G 82
REMARK 465 GLU G 83
REMARK 465 PHE G 84
REMARK 465 SER G 85
REMARK 465 ALA G 86
REMARK 465 ALA G 87
REMARK 465 SER G 88
REMARK 465 ASP G 89
REMARK 465 MET G 90
REMARK 465 ILE G 91
REMARK 465 ASN G 92
REMARK 465 ASN G 93
REMARK 465 ALA G 94
REMARK 465 GLN G 95
REMARK 465 LYS G 96
REMARK 465 ILE G 97
REMARK 465 VAL G 98
REMARK 465 GLN G 99
REMARK 465 GLU G 100
REMARK 465 THR G 101
REMARK 465 GLN G 102
REMARK 465 GLN G 103
REMARK 465 LEU G 104
REMARK 465 SER G 105
REMARK 465 ALA G 106
REMARK 465 ASN G 107
REMARK 465 GLN G 108
REMARK 465 PRO G 109
REMARK 465 LYS G 110
REMARK 465 ASN G 111
REMARK 465 ILE G 112
REMARK 465 THR G 113
REMARK 465 GLN G 114
REMARK 465 PRO G 115
REMARK 465 HIS G 116
REMARK 465 ASN G 117
REMARK 465 LEU G 118
REMARK 465 ASN G 119
REMARK 465 LEU G 120
REMARK 465 ASN G 121
REMARK 465 SER G 122
REMARK 465 PRO G 123
REMARK 465 SER G 124
REMARK 465 SER G 125
REMARK 465 LEU G 126
REMARK 465 THR G 127
REMARK 465 ALA G 128
REMARK 465 LEU G 129
REMARK 465 ALA G 130
REMARK 465 GLN G 131
REMARK 465 LYS G 132
REMARK 465 MET G 133
REMARK 465 LEU G 134
REMARK 465 LYS G 135
REMARK 465 ASN G 136
REMARK 465 ALA G 137
REMARK 465 GLN G 138
REMARK 465 SER G 139
REMARK 465 GLN G 140
REMARK 465 ALA G 141
REMARK 465 GLU G 142
REMARK 465 ILE G 143
REMARK 465 LEU G 144
REMARK 465 LYS G 145
REMARK 465 LEU G 146
REMARK 465 ALA G 147
REMARK 465 ASN G 148
REMARK 465 GLN G 149
REMARK 465 VAL G 150
REMARK 465 GLU G 151
REMARK 465 SER G 152
REMARK 465 ASP G 153
REMARK 465 PHE G 154
REMARK 465 ASN G 155
REMARK 465 LYS G 156
REMARK 465 LEU G 157
REMARK 465 SER G 158
REMARK 465 SER G 159
REMARK 465 GLY G 160
REMARK 465 HIS G 161
REMARK 465 LEU G 162
REMARK 465 LYS G 163
REMARK 465 ASP G 164
REMARK 465 TYR G 165
REMARK 465 ILE G 166
REMARK 465 GLY G 167
REMARK 465 LYS G 168
REMARK 465 CYS G 169
REMARK 465 ASP G 170
REMARK 465 ALA G 171
REMARK 465 SER G 172
REMARK 465 ALA G 173
REMARK 465 ILE G 174
REMARK 465 SER G 175
REMARK 465 SER G 176
REMARK 465 ALA G 177
REMARK 465 ASN G 178
REMARK 465 MET G 179
REMARK 465 THR G 180
REMARK 465 MET G 181
REMARK 465 GLN G 182
REMARK 465 ASN G 183
REMARK 465 GLN G 184
REMARK 465 LYS G 185
REMARK 465 ASN G 186
REMARK 465 ASN G 187
REMARK 465 TRP G 188
REMARK 465 GLY G 189
REMARK 465 ASN G 190
REMARK 465 GLY G 191
REMARK 465 CYS G 192
REMARK 465 ALA G 193
REMARK 465 GLY G 194
REMARK 465 VAL G 195
REMARK 465 GLU G 196
REMARK 465 GLU G 197
REMARK 465 THR G 198
REMARK 465 GLN G 199
REMARK 465 SER G 200
REMARK 465 LEU G 201
REMARK 465 LEU G 202
REMARK 465 LYS G 203
REMARK 465 THR G 204
REMARK 465 SER G 205
REMARK 465 ALA G 206
REMARK 465 ALA G 207
REMARK 465 ASP G 208
REMARK 465 PHE G 209
REMARK 465 ASN G 210
REMARK 465 ASN G 211
REMARK 465 GLN G 212
REMARK 465 THR G 213
REMARK 465 PRO G 214
REMARK 465 GLN G 215
REMARK 465 ILE G 216
REMARK 465 ASN G 217
REMARK 465 GLN G 218
REMARK 465 ALA G 219
REMARK 465 GLN G 220
REMARK 465 ASN G 221
REMARK 465 LEU G 222
REMARK 465 ALA G 223
REMARK 465 ASN G 224
REMARK 465 THR G 225
REMARK 465 LEU G 226
REMARK 465 ILE G 227
REMARK 465 GLN G 228
REMARK 465 GLU G 229
REMARK 465 LEU G 230
REMARK 465 GLY G 231
REMARK 465 ASN G 232
REMARK 465 ASN G 233
REMARK 465 PRO G 234
REMARK 465 PHE G 235
REMARK 465 ARG G 236
REMARK 465 ALA G 237
REMARK 465 SER G 238
REMARK 465 GLY G 239
REMARK 465 GLY G 240
REMARK 465 GLY G 241
REMARK 465 SER G 242
REMARK 465 GLY G 243
REMARK 465 GLY G 244
REMARK 465 GLY G 245
REMARK 465 GLY G 246
REMARK 465 SER G 247
REMARK 465 GLY G 248
REMARK 465 LYS G 249
REMARK 465 LEU G 250
REMARK 465 SER G 251
REMARK 465 ASP G 252
REMARK 465 THR G 253
REMARK 465 TYR G 254
REMARK 465 GLU G 255
REMARK 465 GLN G 256
REMARK 465 LEU G 257
REMARK 465 SER G 258
REMARK 465 ARG G 259
REMARK 465 LEU G 260
REMARK 465 LEU G 261
REMARK 465 THR G 262
REMARK 465 ASN G 263
REMARK 465 ASP G 264
REMARK 465 ASN G 265
REMARK 465 GLY G 266
REMARK 465 THR G 267
REMARK 465 ASN G 268
REMARK 465 SER G 269
REMARK 465 LYS G 270
REMARK 465 THR G 271
REMARK 465 SER G 272
REMARK 465 ALA G 273
REMARK 465 GLN G 274
REMARK 465 ALA G 275
REMARK 465 ILE G 276
REMARK 465 ASN G 277
REMARK 465 GLN G 278
REMARK 465 ALA G 279
REMARK 465 VAL G 280
REMARK 465 ASN G 281
REMARK 465 ASN G 282
REMARK 465 LEU G 283
REMARK 465 ASN G 284
REMARK 465 GLU G 285
REMARK 465 ARG G 286
REMARK 465 ALA G 287
REMARK 465 LYS G 288
REMARK 465 THR G 289
REMARK 465 LEU G 290
REMARK 465 ALA G 291
REMARK 465 GLY G 292
REMARK 465 GLY G 293
REMARK 465 THR G 294
REMARK 465 THR G 295
REMARK 465 ASN G 296
REMARK 465 SER G 297
REMARK 465 PRO G 298
REMARK 465 ALA G 299
REMARK 465 TYR G 300
REMARK 465 GLN G 301
REMARK 465 ALA G 302
REMARK 465 THR G 303
REMARK 465 LEU G 304
REMARK 465 LEU G 305
REMARK 465 ALA G 306
REMARK 465 LEU G 307
REMARK 465 ARG G 308
REMARK 465 SER G 309
REMARK 465 VAL G 310
REMARK 465 LEU G 311
REMARK 465 GLY G 312
REMARK 465 LEU G 313
REMARK 465 TRP G 314
REMARK 465 ASN G 315
REMARK 465 SER G 316
REMARK 465 MET G 317
REMARK 465 GLY G 318
REMARK 465 TYR G 319
REMARK 465 ALA G 320
REMARK 465 VAL G 321
REMARK 465 ILE G 322
REMARK 465 CYS G 323
REMARK 465 GLY G 324
REMARK 465 GLY G 325
REMARK 465 TYR G 326
REMARK 465 THR G 327
REMARK 465 LYS G 328
REMARK 465 SER G 329
REMARK 465 PRO G 330
REMARK 465 GLY G 331
REMARK 465 GLU G 332
REMARK 465 ASN G 333
REMARK 465 ASN G 334
REMARK 465 GLN G 335
REMARK 465 LYS G 336
REMARK 465 ASP G 337
REMARK 465 PHE G 338
REMARK 465 HIS G 339
REMARK 465 TYR G 340
REMARK 465 THR G 341
REMARK 465 ASP G 342
REMARK 465 GLU G 343
REMARK 465 ASN G 344
REMARK 465 GLY G 345
REMARK 465 ASN G 346
REMARK 465 GLY G 347
REMARK 465 THR G 348
REMARK 465 THR G 349
REMARK 465 ILE G 350
REMARK 465 ASN G 351
REMARK 465 CYS G 352
REMARK 465 GLY G 353
REMARK 465 GLY G 354
REMARK 465 SER G 355
REMARK 465 THR G 356
REMARK 465 ASN G 357
REMARK 465 SER G 358
REMARK 465 ASN G 359
REMARK 465 GLY G 360
REMARK 465 THR G 361
REMARK 465 HIS G 362
REMARK 465 SER G 363
REMARK 465 TYR G 364
REMARK 465 ASN G 365
REMARK 465 GLY G 366
REMARK 465 THR G 367
REMARK 465 ASN G 368
REMARK 465 THR G 369
REMARK 465 LEU G 370
REMARK 465 LYS G 371
REMARK 465 ALA G 372
REMARK 465 ASP G 373
REMARK 465 LYS G 374
REMARK 465 ASN G 375
REMARK 465 VAL G 376
REMARK 465 SER G 377
REMARK 465 LEU G 378
REMARK 465 SER G 379
REMARK 465 ILE G 380
REMARK 465 GLU G 381
REMARK 465 GLN G 382
REMARK 465 TYR G 383
REMARK 465 GLU G 384
REMARK 465 LYS G 385
REMARK 465 ILE G 386
REMARK 465 HIS G 387
REMARK 465 GLU G 388
REMARK 465 ALA G 389
REMARK 465 TYR G 390
REMARK 465 GLN G 391
REMARK 465 ILE G 392
REMARK 465 LEU G 393
REMARK 465 SER G 394
REMARK 465 LYS G 395
REMARK 465 ALA G 396
REMARK 465 LEU G 397
REMARK 465 LYS G 398
REMARK 465 GLN G 399
REMARK 465 ALA G 400
REMARK 465 GLY G 401
REMARK 465 LEU G 402
REMARK 465 ALA G 403
REMARK 465 PRO G 404
REMARK 465 LEU G 405
REMARK 465 ASN G 406
REMARK 465 SER G 407
REMARK 465 LYS G 408
REMARK 465 GLY G 409
REMARK 465 GLU G 410
REMARK 465 LYS G 411
REMARK 465 LEU G 412
REMARK 465 GLU G 413
REMARK 465 ALA G 414
REMARK 465 HIS G 415
REMARK 465 VAL G 416
REMARK 465 THR G 417
REMARK 465 THR G 418
REMARK 465 SER G 419
REMARK 465 LYS G 420
REMARK 465 TYR G 421
REMARK 465 HIS G 530
REMARK 465 HIS G 531
REMARK 465 HIS G 532
REMARK 465 HIS G 533
REMARK 465 HIS G 534
REMARK 465 HIS G 535
REMARK 465 GLU G 536
REMARK 465 PRO G 537
REMARK 465 GLU G 538
REMARK 465 ALA G 539
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT
REMARK 500
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.
REMARK 500
REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI DISTANCE
REMARK 500 O6 BMA F 3 O5 MAN F 4 2.16
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)
REMARK 500
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996
REMARK 500
REMARK 500 M RES CSSEQI ATM1 ATM2 ATM3
REMARK 500 ALA G 505 N - CA - C ANGL. DEV. = -18.3 DEGREES
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500 M RES CSSEQI PSI PHI
REMARK 500 MET A 148 31.41 -92.88
REMARK 500 ARG A 173 -168.57 -118.59
REMARK 500 ASN A 189 -61.37 -100.58
REMARK 500 LYS A 279 41.49 -102.48
REMARK 500 LYS A 312 -9.38 74.09
REMARK 500 ASN B 41 111.11 -160.04
REMARK 500 ASP B 95 54.64 -90.22
REMARK 500 LEU B 140 34.82 -98.70
REMARK 500 PRO B 144 30.61 -97.40
REMARK 500 PRO B 276 49.03 -89.69
REMARK 500 ALA B 280 -3.92 65.48
REMARK 500 VAL C 48 -62.03 -120.51
REMARK 500 LYS C 94 -9.55 73.12
REMARK 500 PRO C 159 46.95 -98.35
REMARK 500 PRO C 175 -168.84 -74.14
REMARK 500 THR C 193 -7.15 72.75
REMARK 500 ARG C 197 50.13 -94.55
REMARK 500 LYS D 105 -63.64 -91.62
REMARK 500 LEU D 143 32.21 -94.75
REMARK 500 MET D 148 52.33 -92.60
REMARK 500 ARG D 173 -166.80 -119.93
REMARK 500 LEU D 194 52.87 -91.75
REMARK 500 SER D 276 34.60 -98.88
REMARK 500 LYS D 279 54.06 -92.31
REMARK 500 LYS D 312 -6.08 72.75
REMARK 500 SER D 390 72.11 60.85
REMARK 500 ASP E 95 54.21 -93.26
REMARK 500 LEU E 140 32.87 -97.74
REMARK 500 PHE G 435 36.82 -99.34
REMARK 500 ARG G 472 -60.46 -95.08
REMARK 500 LEU G 510 -6.69 68.33
REMARK 500
REMARK 500 REMARK: NULL
REMARK 900
REMARK 900 RELATED ENTRIES
REMARK 900 RELATED ID: EMD-0282 RELATED DB: EMDB
REMARK 900 CRYOEM STRUCTURE OF HUMAN FULL-LENGTH HETEROMERIC
REMARK 900 ALPHA1BETA3GAMMA2L GABA(A)R IN COMPLEX WITH ALPRAZOLAM (XANAX),
REMARK 900 GABA AND MEGABODY MB38.
DBREF 6HUO A -34 -8 UNP P08219 GBRA1_BOVIN 1 27
DBREF 6HUO A 1 429 UNP P14867 GBRA1_HUMAN 28 456
DBREF 6HUO B -24 448 UNP P28472 GBRB3_HUMAN 1 473
DBREF 6HUO C -38 436 UNP P18507 GBRG2_HUMAN 1 475
DBREF 6HUO D -34 -8 UNP P08219 GBRA1_BOVIN 1 27
DBREF 6HUO D 1 429 UNP P14867 GBRA1_HUMAN 28 456
DBREF 6HUO E -24 448 UNP P28472 GBRB3_HUMAN 1 473
DBREF 6HUO G 1 539 PDB 6HUO 6HUO 1 539
SEQADV 6HUO ASP A -7 UNP P08219 LINKER
SEQADV 6HUO TYR A -6 UNP P08219 LINKER
SEQADV 6HUO LYS A -5 UNP P08219 LINKER
SEQADV 6HUO ASP A -4 UNP P08219 LINKER
SEQADV 6HUO ASP A -3 UNP P08219 LINKER
SEQADV 6HUO ASP A -2 UNP P08219 LINKER
SEQADV 6HUO ASP A -1 UNP P08219 LINKER
SEQADV 6HUO LYS A 0 UNP P08219 LINKER
SEQADV 6HUO GLY C 437 UNP P18507 EXPRESSION TAG
SEQADV 6HUO GLY C 438 UNP P18507 EXPRESSION TAG
SEQADV 6HUO SER C 439 UNP P18507 EXPRESSION TAG
SEQADV 6HUO GLY C 440 UNP P18507 EXPRESSION TAG
SEQADV 6HUO GLY C 441 UNP P18507 EXPRESSION TAG
SEQADV 6HUO SER C 442 UNP P18507 EXPRESSION TAG
SEQADV 6HUO GLY C 443 UNP P18507 EXPRESSION TAG
SEQADV 6HUO GLY C 444 UNP P18507 EXPRESSION TAG
SEQADV 6HUO SER C 445 UNP P18507 EXPRESSION TAG
SEQADV 6HUO GLY C 446 UNP P18507 EXPRESSION TAG
SEQADV 6HUO LYS C 447 UNP P18507 EXPRESSION TAG
SEQADV 6HUO THR C 448 UNP P18507 EXPRESSION TAG
SEQADV 6HUO GLU C 449 UNP P18507 EXPRESSION TAG
SEQADV 6HUO THR C 450 UNP P18507 EXPRESSION TAG
SEQADV 6HUO SER C 451 UNP P18507 EXPRESSION TAG
SEQADV 6HUO GLN C 452 UNP P18507 EXPRESSION TAG
SEQADV 6HUO VAL C 453 UNP P18507 EXPRESSION TAG
SEQADV 6HUO ALA C 454 UNP P18507 EXPRESSION TAG
SEQADV 6HUO PRO C 455 UNP P18507 EXPRESSION TAG
SEQADV 6HUO ALA C 456 UNP P18507 EXPRESSION TAG
SEQADV 6HUO ASP D -7 UNP P08219 LINKER
SEQADV 6HUO TYR D -6 UNP P08219 LINKER
SEQADV 6HUO LYS D -5 UNP P08219 LINKER
SEQADV 6HUO ASP D -4 UNP P08219 LINKER
SEQADV 6HUO ASP D -3 UNP P08219 LINKER
SEQADV 6HUO ASP D -2 UNP P08219 LINKER
SEQADV 6HUO ASP D -1 UNP P08219 LINKER
SEQADV 6HUO LYS D 0 UNP P08219 LINKER
SEQRES 1 A 464 MET LYS LYS SER PRO GLY LEU SER ASP TYR LEU TRP ALA
SEQRES 2 A 464 TRP THR LEU PHE LEU SER THR LEU THR GLY ARG SER TYR
SEQRES 3 A 464 GLY ASP TYR LYS ASP ASP ASP ASP LYS GLN PRO SER LEU
SEQRES 4 A 464 GLN ASP GLU LEU LYS ASP ASN THR THR VAL PHE THR ARG
SEQRES 5 A 464 ILE LEU ASP ARG LEU LEU ASP GLY TYR ASP ASN ARG LEU
SEQRES 6 A 464 ARG PRO GLY LEU GLY GLU ARG VAL THR GLU VAL LYS THR
SEQRES 7 A 464 ASP ILE PHE VAL THR SER PHE GLY PRO VAL SER ASP HIS
SEQRES 8 A 464 ASP MET GLU TYR THR ILE ASP VAL PHE PHE ARG GLN SER
SEQRES 9 A 464 TRP LYS ASP GLU ARG LEU LYS PHE LYS GLY PRO MET THR
SEQRES 10 A 464 VAL LEU ARG LEU ASN ASN LEU MET ALA SER LYS ILE TRP
SEQRES 11 A 464 THR PRO ASP THR PHE PHE HIS ASN GLY LYS LYS SER VAL
SEQRES 12 A 464 ALA HIS ASN MET THR MET PRO ASN LYS LEU LEU ARG ILE
SEQRES 13 A 464 THR GLU ASP GLY THR LEU LEU TYR THR MET ARG LEU THR
SEQRES 14 A 464 VAL ARG ALA GLU CYS PRO MET HIS LEU GLU ASP PHE PRO
SEQRES 15 A 464 MET ASP ALA HIS ALA CYS PRO LEU LYS PHE GLY SER TYR
SEQRES 16 A 464 ALA TYR THR ARG ALA GLU VAL VAL TYR GLU TRP THR ARG
SEQRES 17 A 464 GLU PRO ALA ARG SER VAL VAL VAL ALA GLU ASP GLY SER
SEQRES 18 A 464 ARG LEU ASN GLN TYR ASP LEU LEU GLY GLN THR VAL ASP
SEQRES 19 A 464 SER GLY ILE VAL GLN SER SER THR GLY GLU TYR VAL VAL
SEQRES 20 A 464 MET THR THR HIS PHE HIS LEU LYS ARG LYS ILE GLY TYR
SEQRES 21 A 464 PHE VAL ILE GLN THR TYR LEU PRO CYS ILE MET THR VAL
SEQRES 22 A 464 ILE LEU SER GLN VAL SER PHE TRP LEU ASN ARG GLU SER
SEQRES 23 A 464 VAL PRO ALA ARG THR VAL PHE GLY VAL THR THR VAL LEU
SEQRES 24 A 464 THR MET THR THR LEU SER ILE SER ALA ARG ASN SER LEU
SEQRES 25 A 464 PRO LYS VAL ALA TYR ALA THR ALA MET ASP TRP PHE ILE
SEQRES 26 A 464 ALA VAL CYS TYR ALA PHE VAL PHE SER ALA LEU ILE GLU
SEQRES 27 A 464 PHE ALA THR VAL ASN TYR PHE THR LYS ARG GLY TYR ALA
SEQRES 28 A 464 TRP ASP GLY LYS SER VAL VAL PRO GLU LYS PRO LYS LYS
SEQRES 29 A 464 VAL LYS ASP PRO LEU ILE LYS LYS ASN ASN THR TYR ALA
SEQRES 30 A 464 PRO THR ALA THR SER TYR THR PRO ASN LEU ALA ARG GLY
SEQRES 31 A 464 ASP PRO GLY LEU ALA THR ILE ALA LYS SER ALA THR ILE
SEQRES 32 A 464 GLU PRO LYS GLU VAL LYS PRO GLU THR LYS PRO PRO GLU
SEQRES 33 A 464 PRO LYS LYS THR PHE ASN SER VAL SER LYS ILE ASP ARG
SEQRES 34 A 464 LEU SER ARG ILE ALA PHE PRO LEU LEU PHE GLY ILE PHE
SEQRES 35 A 464 ASN LEU VAL TYR TRP ALA THR TYR LEU ASN ARG GLU PRO
SEQRES 36 A 464 GLN LEU LYS ALA PRO THR PRO HIS GLN
SEQRES 1 B 473 MET CYS SER GLY LEU LEU GLU LEU LEU LEU PRO ILE TRP
SEQRES 2 B 473 LEU SER TRP THR LEU GLY THR ARG GLY SER GLU PRO ARG
SEQRES 3 B 473 SER VAL ASN ASP PRO GLY ASN MET SER PHE VAL LYS GLU
SEQRES 4 B 473 THR VAL ASP LYS LEU LEU LYS GLY TYR ASP ILE ARG LEU
SEQRES 5 B 473 ARG PRO ASP PHE GLY GLY PRO PRO VAL CYS VAL GLY MET
SEQRES 6 B 473 ASN ILE ASP ILE ALA SER ILE ASP MET VAL SER GLU VAL
SEQRES 7 B 473 ASN MET ASP TYR THR LEU THR MET TYR PHE GLN GLN TYR
SEQRES 8 B 473 TRP ARG ASP LYS ARG LEU ALA TYR SER GLY ILE PRO LEU
SEQRES 9 B 473 ASN LEU THR LEU ASP ASN ARG VAL ALA ASP GLN LEU TRP
SEQRES 10 B 473 VAL PRO ASP THR TYR PHE LEU ASN ASP LYS LYS SER PHE
SEQRES 11 B 473 VAL HIS GLY VAL THR VAL LYS ASN ARG MET ILE ARG LEU
SEQRES 12 B 473 HIS PRO ASP GLY THR VAL LEU TYR GLY LEU ARG ILE THR
SEQRES 13 B 473 THR THR ALA ALA CYS MET MET ASP LEU ARG ARG TYR PRO
SEQRES 14 B 473 LEU ASP GLU GLN ASN CYS THR LEU GLU ILE GLU SER TYR
SEQRES 15 B 473 GLY TYR THR THR ASP ASP ILE GLU PHE TYR TRP ARG GLY
SEQRES 16 B 473 GLY ASP LYS ALA VAL THR GLY VAL GLU ARG ILE GLU LEU
SEQRES 17 B 473 PRO GLN PHE SER ILE VAL GLU HIS ARG LEU VAL SER ARG
SEQRES 18 B 473 ASN VAL VAL PHE ALA THR GLY ALA TYR PRO ARG LEU SER
SEQRES 19 B 473 LEU SER PHE ARG LEU LYS ARG ASN ILE GLY TYR PHE ILE
SEQRES 20 B 473 LEU GLN THR TYR MET PRO SER ILE LEU ILE THR ILE LEU
SEQRES 21 B 473 SER TRP VAL SER PHE TRP ILE ASN TYR ASP ALA SER ALA
SEQRES 22 B 473 ALA ARG VAL ALA LEU GLY ILE THR THR VAL LEU THR MET
SEQRES 23 B 473 THR THR ILE ASN THR HIS LEU ARG GLU THR LEU PRO LYS
SEQRES 24 B 473 ILE PRO TYR VAL LYS ALA ILE ASP MET TYR LEU MET GLY
SEQRES 25 B 473 CYS PHE VAL PHE VAL PHE LEU ALA LEU LEU GLU TYR ALA
SEQRES 26 B 473 PHE VAL ASN TYR ILE PHE PHE GLY ARG GLY PRO GLN ARG
SEQRES 27 B 473 GLN LYS LYS LEU ALA GLU LYS THR ALA LYS ALA LYS ASN
SEQRES 28 B 473 ASP ARG SER LYS SER GLU SER ASN ARG VAL ASP ALA HIS
SEQRES 29 B 473 GLY ASN ILE LEU LEU THR SER LEU GLU VAL HIS ASN GLU
SEQRES 30 B 473 MET ASN GLU VAL SER GLY GLY ILE GLY ASP THR ARG ASN
SEQRES 31 B 473 SER ALA ILE SER PHE ASP ASN SER GLY ILE GLN TYR ARG
SEQRES 32 B 473 LYS GLN SER MET PRO ARG GLU GLY HIS GLY ARG PHE LEU
SEQRES 33 B 473 GLY ASP ARG SER LEU PRO HIS LYS LYS THR HIS LEU ARG
SEQRES 34 B 473 ARG ARG SER SER GLN LEU LYS ILE LYS ILE PRO ASP LEU
SEQRES 35 B 473 THR ASP VAL ASN ALA ILE ASP ARG TRP SER ARG ILE VAL
SEQRES 36 B 473 PHE PRO PHE THR PHE SER LEU PHE ASN LEU VAL TYR TRP
SEQRES 37 B 473 LEU TYR TYR VAL ASN
SEQRES 1 C 495 MET SER SER PRO ASN ILE TRP SER THR GLY SER SER VAL
SEQRES 2 C 495 TYR SER THR PRO VAL PHE SER GLN LYS MET THR VAL TRP
SEQRES 3 C 495 ILE LEU LEU LEU LEU SER LEU TYR PRO GLY PHE THR SER
SEQRES 4 C 495 GLN LYS SER ASP ASP ASP TYR GLU ASP TYR ALA SER ASN
SEQRES 5 C 495 LYS THR TRP VAL LEU THR PRO LYS VAL PRO GLU GLY ASP
SEQRES 6 C 495 VAL THR VAL ILE LEU ASN ASN LEU LEU GLU GLY TYR ASP
SEQRES 7 C 495 ASN LYS LEU ARG PRO ASP ILE GLY VAL LYS PRO THR LEU
SEQRES 8 C 495 ILE HIS THR ASP MET TYR VAL ASN SER ILE GLY PRO VAL
SEQRES 9 C 495 ASN ALA ILE ASN MET GLU TYR THR ILE ASP ILE PHE PHE
SEQRES 10 C 495 ALA GLN THR TRP TYR ASP ARG ARG LEU LYS PHE ASN SER
SEQRES 11 C 495 THR ILE LYS VAL LEU ARG LEU ASN SER ASN MET VAL GLY
SEQRES 12 C 495 LYS ILE TRP ILE PRO ASP THR PHE PHE ARG ASN SER LYS
SEQRES 13 C 495 LYS ALA ASP ALA HIS TRP ILE THR THR PRO ASN ARG MET
SEQRES 14 C 495 LEU ARG ILE TRP ASN ASP GLY ARG VAL LEU TYR THR LEU
SEQRES 15 C 495 ARG LEU THR ILE ASP ALA GLU CYS GLN LEU GLN LEU HIS
SEQRES 16 C 495 ASN PHE PRO MET ASP GLU HIS SER CYS PRO LEU GLU PHE
SEQRES 17 C 495 SER SER TYR GLY TYR PRO ARG GLU GLU ILE VAL TYR GLN
SEQRES 18 C 495 TRP LYS ARG SER SER VAL GLU VAL GLY ASP THR ARG SER
SEQRES 19 C 495 TRP ARG LEU TYR GLN PHE SER PHE VAL GLY LEU ARG ASN
SEQRES 20 C 495 THR THR GLU VAL VAL LYS THR THR SER GLY ASP TYR VAL
SEQRES 21 C 495 VAL MET SER VAL TYR PHE ASP LEU SER ARG ARG MET GLY
SEQRES 22 C 495 TYR PHE THR ILE GLN THR TYR ILE PRO CYS THR LEU ILE
SEQRES 23 C 495 VAL VAL LEU SER TRP VAL SER PHE TRP ILE ASN LYS ASP
SEQRES 24 C 495 ALA VAL PRO ALA ARG THR SER LEU GLY ILE THR THR VAL
SEQRES 25 C 495 LEU THR MET THR THR LEU SER THR ILE ALA ARG LYS SER
SEQRES 26 C 495 LEU PRO LYS VAL SER TYR VAL THR ALA MET ASP LEU PHE
SEQRES 27 C 495 VAL SER VAL CYS PHE ILE PHE VAL PHE SER ALA LEU VAL
SEQRES 28 C 495 GLU TYR GLY THR LEU HIS TYR PHE VAL SER ASN ARG LYS
SEQRES 29 C 495 PRO SER LYS ASP LYS ASP LYS LYS LYS LYS ASN PRO LEU
SEQRES 30 C 495 LEU ARG MET PHE SER PHE LYS ALA PRO THR ILE ASP ILE
SEQRES 31 C 495 ARG PRO ARG SER ALA THR ILE GLN MET ASN ASN ALA THR
SEQRES 32 C 495 HIS LEU GLN GLU ARG ASP GLU GLU TYR GLY TYR GLU CYS
SEQRES 33 C 495 LEU ASP GLY LYS ASP CYS ALA SER PHE PHE CYS CYS PHE
SEQRES 34 C 495 GLU ASP CYS ARG THR GLY ALA TRP ARG HIS GLY ARG ILE
SEQRES 35 C 495 HIS ILE ARG ILE ALA LYS MET ASP SER TYR ALA ARG ILE
SEQRES 36 C 495 PHE PHE PRO THR ALA PHE CYS LEU PHE ASN LEU VAL TYR
SEQRES 37 C 495 TRP VAL SER TYR LEU TYR LEU GLY GLY SER GLY GLY SER
SEQRES 38 C 495 GLY GLY SER GLY LYS THR GLU THR SER GLN VAL ALA PRO
SEQRES 39 C 495 ALA
SEQRES 1 D 464 MET LYS LYS SER PRO GLY LEU SER ASP TYR LEU TRP ALA
SEQRES 2 D 464 TRP THR LEU PHE LEU SER THR LEU THR GLY ARG SER TYR
SEQRES 3 D 464 GLY ASP TYR LYS ASP ASP ASP ASP LYS GLN PRO SER LEU
SEQRES 4 D 464 GLN ASP GLU LEU LYS ASP ASN THR THR VAL PHE THR ARG
SEQRES 5 D 464 ILE LEU ASP ARG LEU LEU ASP GLY TYR ASP ASN ARG LEU
SEQRES 6 D 464 ARG PRO GLY LEU GLY GLU ARG VAL THR GLU VAL LYS THR
SEQRES 7 D 464 ASP ILE PHE VAL THR SER PHE GLY PRO VAL SER ASP HIS
SEQRES 8 D 464 ASP MET GLU TYR THR ILE ASP VAL PHE PHE ARG GLN SER
SEQRES 9 D 464 TRP LYS ASP GLU ARG LEU LYS PHE LYS GLY PRO MET THR
SEQRES 10 D 464 VAL LEU ARG LEU ASN ASN LEU MET ALA SER LYS ILE TRP
SEQRES 11 D 464 THR PRO ASP THR PHE PHE HIS ASN GLY LYS LYS SER VAL
SEQRES 12 D 464 ALA HIS ASN MET THR MET PRO ASN LYS LEU LEU ARG ILE
SEQRES 13 D 464 THR GLU ASP GLY THR LEU LEU TYR THR MET ARG LEU THR
SEQRES 14 D 464 VAL ARG ALA GLU CYS PRO MET HIS LEU GLU ASP PHE PRO
SEQRES 15 D 464 MET ASP ALA HIS ALA CYS PRO LEU LYS PHE GLY SER TYR
SEQRES 16 D 464 ALA TYR THR ARG ALA GLU VAL VAL TYR GLU TRP THR ARG
SEQRES 17 D 464 GLU PRO ALA ARG SER VAL VAL VAL ALA GLU ASP GLY SER
SEQRES 18 D 464 ARG LEU ASN GLN TYR ASP LEU LEU GLY GLN THR VAL ASP
SEQRES 19 D 464 SER GLY ILE VAL GLN SER SER THR GLY GLU TYR VAL VAL
SEQRES 20 D 464 MET THR THR HIS PHE HIS LEU LYS ARG LYS ILE GLY TYR
SEQRES 21 D 464 PHE VAL ILE GLN THR TYR LEU PRO CYS ILE MET THR VAL
SEQRES 22 D 464 ILE LEU SER GLN VAL SER PHE TRP LEU ASN ARG GLU SER
SEQRES 23 D 464 VAL PRO ALA ARG THR VAL PHE GLY VAL THR THR VAL LEU
SEQRES 24 D 464 THR MET THR THR LEU SER ILE SER ALA ARG ASN SER LEU
SEQRES 25 D 464 PRO LYS VAL ALA TYR ALA THR ALA MET ASP TRP PHE ILE
SEQRES 26 D 464 ALA VAL CYS TYR ALA PHE VAL PHE SER ALA LEU ILE GLU
SEQRES 27 D 464 PHE ALA THR VAL ASN TYR PHE THR LYS ARG GLY TYR ALA
SEQRES 28 D 464 TRP ASP GLY LYS SER VAL VAL PRO GLU LYS PRO LYS LYS
SEQRES 29 D 464 VAL LYS ASP PRO LEU ILE LYS LYS ASN ASN THR TYR ALA
SEQRES 30 D 464 PRO THR ALA THR SER TYR THR PRO ASN LEU ALA ARG GLY
SEQRES 31 D 464 ASP PRO GLY LEU ALA THR ILE ALA LYS SER ALA THR ILE
SEQRES 32 D 464 GLU PRO LYS GLU VAL LYS PRO GLU THR LYS PRO PRO GLU
SEQRES 33 D 464 PRO LYS LYS THR PHE ASN SER VAL SER LYS ILE ASP ARG
SEQRES 34 D 464 LEU SER ARG ILE ALA PHE PRO LEU LEU PHE GLY ILE PHE
SEQRES 35 D 464 ASN LEU VAL TYR TRP ALA THR TYR LEU ASN ARG GLU PRO
SEQRES 36 D 464 GLN LEU LYS ALA PRO THR PRO HIS GLN
SEQRES 1 E 473 MET CYS SER GLY LEU LEU GLU LEU LEU LEU PRO ILE TRP
SEQRES 2 E 473 LEU SER TRP THR LEU GLY THR ARG GLY SER GLU PRO ARG
SEQRES 3 E 473 SER VAL ASN ASP PRO GLY ASN MET SER PHE VAL LYS GLU
SEQRES 4 E 473 THR VAL ASP LYS LEU LEU LYS GLY TYR ASP ILE ARG LEU
SEQRES 5 E 473 ARG PRO ASP PHE GLY GLY PRO PRO VAL CYS VAL GLY MET
SEQRES 6 E 473 ASN ILE ASP ILE ALA SER ILE ASP MET VAL SER GLU VAL
SEQRES 7 E 473 ASN MET ASP TYR THR LEU THR MET TYR PHE GLN GLN TYR
SEQRES 8 E 473 TRP ARG ASP LYS ARG LEU ALA TYR SER GLY ILE PRO LEU
SEQRES 9 E 473 ASN LEU THR LEU ASP ASN ARG VAL ALA ASP GLN LEU TRP
SEQRES 10 E 473 VAL PRO ASP THR TYR PHE LEU ASN ASP LYS LYS SER PHE
SEQRES 11 E 473 VAL HIS GLY VAL THR VAL LYS ASN ARG MET ILE ARG LEU
SEQRES 12 E 473 HIS PRO ASP GLY THR VAL LEU TYR GLY LEU ARG ILE THR
SEQRES 13 E 473 THR THR ALA ALA CYS MET MET ASP LEU ARG ARG TYR PRO
SEQRES 14 E 473 LEU ASP GLU GLN ASN CYS THR LEU GLU ILE GLU SER TYR
SEQRES 15 E 473 GLY TYR THR THR ASP ASP ILE GLU PHE TYR TRP ARG GLY
SEQRES 16 E 473 GLY ASP LYS ALA VAL THR GLY VAL GLU ARG ILE GLU LEU
SEQRES 17 E 473 PRO GLN PHE SER ILE VAL GLU HIS ARG LEU VAL SER ARG
SEQRES 18 E 473 ASN VAL VAL PHE ALA THR GLY ALA TYR PRO ARG LEU SER
SEQRES 19 E 473 LEU SER PHE ARG LEU LYS ARG ASN ILE GLY TYR PHE ILE
SEQRES 20 E 473 LEU GLN THR TYR MET PRO SER ILE LEU ILE THR ILE LEU
SEQRES 21 E 473 SER TRP VAL SER PHE TRP ILE ASN TYR ASP ALA SER ALA
SEQRES 22 E 473 ALA ARG VAL ALA LEU GLY ILE THR THR VAL LEU THR MET
SEQRES 23 E 473 THR THR ILE ASN THR HIS LEU ARG GLU THR LEU PRO LYS
SEQRES 24 E 473 ILE PRO TYR VAL LYS ALA ILE ASP MET TYR LEU MET GLY
SEQRES 25 E 473 CYS PHE VAL PHE VAL PHE LEU ALA LEU LEU GLU TYR ALA
SEQRES 26 E 473 PHE VAL ASN TYR ILE PHE PHE GLY ARG GLY PRO GLN ARG
SEQRES 27 E 473 GLN LYS LYS LEU ALA GLU LYS THR ALA LYS ALA LYS ASN
SEQRES 28 E 473 ASP ARG SER LYS SER GLU SER ASN ARG VAL ASP ALA HIS
SEQRES 29 E 473 GLY ASN ILE LEU LEU THR SER LEU GLU VAL HIS ASN GLU
SEQRES 30 E 473 MET ASN GLU VAL SER GLY GLY ILE GLY ASP THR ARG ASN
SEQRES 31 E 473 SER ALA ILE SER PHE ASP ASN SER GLY ILE GLN TYR ARG
SEQRES 32 E 473 LYS GLN SER MET PRO ARG GLU GLY HIS GLY ARG PHE LEU
SEQRES 33 E 473 GLY ASP ARG SER LEU PRO HIS LYS LYS THR HIS LEU ARG
SEQRES 34 E 473 ARG ARG SER SER GLN LEU LYS ILE LYS ILE PRO ASP LEU
SEQRES 35 E 473 THR ASP VAL ASN ALA ILE ASP ARG TRP SER ARG ILE VAL
SEQRES 36 E 473 PHE PRO PHE THR PHE SER LEU PHE ASN LEU VAL TYR TRP
SEQRES 37 E 473 LEU TYR TYR VAL ASN
SEQRES 1 G 539 GLN VAL GLN LEU GLN GLU SER GLY GLY GLY LEU VAL GLN
SEQRES 2 G 539 THR LYS THR THR THR SER VAL ILE ASP THR THR ASN ASP
SEQRES 3 G 539 ALA GLN ASN LEU LEU THR GLN ALA GLN THR ILE VAL ASN
SEQRES 4 G 539 THR LEU LYS ASP TYR CYS PRO ILE LEU ILE ALA LYS SER
SEQRES 5 G 539 SER SER SER ASN GLY GLY THR ASN ASN ALA ASN THR PRO
SEQRES 6 G 539 SER TRP GLN THR ALA GLY GLY GLY LYS ASN SER CYS ALA
SEQRES 7 G 539 THR PHE GLY ALA GLU PHE SER ALA ALA SER ASP MET ILE
SEQRES 8 G 539 ASN ASN ALA GLN LYS ILE VAL GLN GLU THR GLN GLN LEU
SEQRES 9 G 539 SER ALA ASN GLN PRO LYS ASN ILE THR GLN PRO HIS ASN
SEQRES 10 G 539 LEU ASN LEU ASN SER PRO SER SER LEU THR ALA LEU ALA
SEQRES 11 G 539 GLN LYS MET LEU LYS ASN ALA GLN SER GLN ALA GLU ILE
SEQRES 12 G 539 LEU LYS LEU ALA ASN GLN VAL GLU SER ASP PHE ASN LYS
SEQRES 13 G 539 LEU SER SER GLY HIS LEU LYS ASP TYR ILE GLY LYS CYS
SEQRES 14 G 539 ASP ALA SER ALA ILE SER SER ALA ASN MET THR MET GLN
SEQRES 15 G 539 ASN GLN LYS ASN ASN TRP GLY ASN GLY CYS ALA GLY VAL
SEQRES 16 G 539 GLU GLU THR GLN SER LEU LEU LYS THR SER ALA ALA ASP
SEQRES 17 G 539 PHE ASN ASN GLN THR PRO GLN ILE ASN GLN ALA GLN ASN
SEQRES 18 G 539 LEU ALA ASN THR LEU ILE GLN GLU LEU GLY ASN ASN PRO
SEQRES 19 G 539 PHE ARG ALA SER GLY GLY GLY SER GLY GLY GLY GLY SER
SEQRES 20 G 539 GLY LYS LEU SER ASP THR TYR GLU GLN LEU SER ARG LEU
SEQRES 21 G 539 LEU THR ASN ASP ASN GLY THR ASN SER LYS THR SER ALA
SEQRES 22 G 539 GLN ALA ILE ASN GLN ALA VAL ASN ASN LEU ASN GLU ARG
SEQRES 23 G 539 ALA LYS THR LEU ALA GLY GLY THR THR ASN SER PRO ALA
SEQRES 24 G 539 TYR GLN ALA THR LEU LEU ALA LEU ARG SER VAL LEU GLY
SEQRES 25 G 539 LEU TRP ASN SER MET GLY TYR ALA VAL ILE CYS GLY GLY
SEQRES 26 G 539 TYR THR LYS SER PRO GLY GLU ASN ASN GLN LYS ASP PHE
SEQRES 27 G 539 HIS TYR THR ASP GLU ASN GLY ASN GLY THR THR ILE ASN
SEQRES 28 G 539 CYS GLY GLY SER THR ASN SER ASN GLY THR HIS SER TYR
SEQRES 29 G 539 ASN GLY THR ASN THR LEU LYS ALA ASP LYS ASN VAL SER
SEQRES 30 G 539 LEU SER ILE GLU GLN TYR GLU LYS ILE HIS GLU ALA TYR
SEQRES 31 G 539 GLN ILE LEU SER LYS ALA LEU LYS GLN ALA GLY LEU ALA
SEQRES 32 G 539 PRO LEU ASN SER LYS GLY GLU LYS LEU GLU ALA HIS VAL
SEQRES 33 G 539 THR THR SER LYS TYR GLY SER LEU ARG VAL SER CYS ALA
SEQRES 34 G 539 ALA SER GLY ARG THR PHE THR THR TYR ILE MET ALA TRP
SEQRES 35 G 539 PHE ARG GLN ALA PRO GLY LYS GLU ARG GLU PHE LEU ALA
SEQRES 36 G 539 ALA MET ASP GLN GLY ARG ILE GLN TYR TYR GLY ASP SER
SEQRES 37 G 539 VAL ARG GLY ARG PHE THR ILE SER ARG ASP TYR ALA LYS
SEQRES 38 G 539 ASN SER VAL ASP LEU GLN LEU ASP GLY LEU ARG PRO GLU
SEQRES 39 G 539 ASP THR ALA VAL TYR TYR CYS ALA ALA GLY ALA GLY PHE
SEQRES 40 G 539 TRP GLY LEU ARG THR ALA SER SER TYR HIS TYR TRP GLY
SEQRES 41 G 539 GLN GLY THR GLN VAL THR VAL SER SER HIS HIS HIS HIS
SEQRES 42 G 539 HIS HIS GLU PRO GLU ALA
HET NAG F 1 14
HET NAG F 2 14
HET BMA F 3 11
HET MAN F 4 11
HET MAN F 5 11
HET MAN F 6 11
HET MAN F 7 11
HET NAG H 1 14
HET NAG H 2 14
HET NAG I 1 14
HET NAG I 2 14
HET BMA I 3 11
HET MAN I 4 11
HET MAN I 5 11
HET MAN I 6 11
HET NAG J 1 14
HET NAG J 2 14
HET NAG K 1 14
HET NAG K 2 14
HET BMA K 3 11
HET MAN K 4 11
HET MAN K 5 11
HET NAG L 1 14
HET NAG L 2 14
HET NAG M 1 14
HET NAG M 2 14
HET BMA M 3 11
HET MAN M 4 11
HET MAN M 5 11
HET MAN M 6 11
HET ABU A 501 7
HET PIO A 502 47
HET 08H D 501 22
HET PIO D 502 47
HET ABU E 501 7
HETNAM NAG 2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSE
HETNAM BMA BETA-D-MANNOPYRANOSE
HETNAM MAN ALPHA-D-MANNOPYRANOSE
HETNAM ABU GAMMA-AMINO-BUTANOIC ACID
HETNAM PIO [(2R)-2-OCTANOYLOXY-3-[OXIDANYL-[(1R,2R,3S,4R,5R,6S)-2,
HETNAM 2 PIO 3,6-TRIS(OXIDANYL)-4,5-DIPHOSPHONOOXY-CYCLOHEXYL]OXY-
HETNAM 3 PIO PHOSPHORYL]OXY-PROPYL] OCTANOATE
HETNAM 08H 8-CHLORO-1-METHYL-6-PHENYL-4H-[1,2,4]TRIAZOLO[4,3-A][1,
HETNAM 2 08H 4]BENZODIAZEPINE
HETSYN NAG N-ACETYL-BETA-D-GLUCOSAMINE; 2-ACETAMIDO-2-DEOXY-BETA-
HETSYN 2 NAG D-GLUCOSE; 2-ACETAMIDO-2-DEOXY-D-GLUCOSE; 2-ACETAMIDO-
HETSYN 3 NAG 2-DEOXY-GLUCOSE; N-ACETYL-D-GLUCOSAMINE
HETSYN BMA BETA-D-MANNOSE; D-MANNOSE; MANNOSE
HETSYN MAN ALPHA-D-MANNOSE; D-MANNOSE; MANNOSE
HETSYN ABU GAMMA(AMINO)-BUTYRIC ACID
HETSYN PIO DIOCTANOYL L-ALPHA-PHOSPHATIDYL-D-MYO-INOSITOL 4,5-
HETSYN 2 PIO DIPHOSPHATE
HETSYN 08H ALPRAZOLAM
FORMUL 7 NAG 14(C8 H15 N O6)
FORMUL 7 BMA 4(C6 H12 O6)
FORMUL 7 MAN 12(C6 H12 O6)
FORMUL 14 ABU 2(C4 H9 N O2)
FORMUL 15 PIO 2(C25 H49 O19 P3)
FORMUL 16 08H C17 H13 CL N4
HELIX 1 AA1 THR A 13 LEU A 23 1 11
HELIX 2 AA2 GLU A 73 LYS A 76 5 4
HELIX 3 AA3 LEU A 89 LYS A 93 5 5
HELIX 4 AA4 HIS A 142 PHE A 146 5 5
HELIX 5 AA5 GLU A 174 ARG A 177 5 4
HELIX 6 AA6 ILE A 223 THR A 230 1 8
HELIX 7 AA7 THR A 230 GLN A 242 1 13
HELIX 8 AA8 VAL A 243 TRP A 246 5 4
HELIX 9 AA9 SER A 251 SER A 276 1 26
HELIX 10 AB1 THR A 284 PHE A 310 1 27
HELIX 11 AB2 SER A 390 LEU A 416 1 27
HELIX 12 AB3 MET B 9 LEU B 20 1 12
HELIX 13 AB4 LYS B 70 ALA B 73 5 4
HELIX 14 AB5 ASP B 84 LEU B 91 5 8
HELIX 15 AB6 ILE B 218 LEU B 223 1 6
HELIX 16 AB7 THR B 225 SER B 236 1 12
HELIX 17 AB8 TRP B 237 TRP B 241 5 5
HELIX 18 AB9 ALA B 246 THR B 271 1 26
HELIX 19 AC1 ILE B 281 GLY B 308 1 28
HELIX 20 AC2 ASP B 419 TYR B 446 1 28
HELIX 21 AC3 VAL C 27 LEU C 35 1 9
HELIX 22 AC4 ARG C 85 LYS C 88 5 4
HELIX 23 AC5 MET C 102 ILE C 106 5 5
HELIX 24 AC6 MET C 233 ILE C 238 1 6
HELIX 25 AC7 THR C 240 VAL C 253 1 14
HELIX 26 AC8 SER C 254 ILE C 257 5 4
HELIX 27 AC9 ALA C 261 LEU C 287 1 27
HELIX 28 AD1 THR C 294 SER C 322 1 29
HELIX 29 AD2 LYS C 409 TYR C 435 1 27
HELIX 30 AD3 VAL D 14 LEU D 23 1 10
HELIX 31 AD4 GLU D 73 LYS D 76 5 4
HELIX 32 AD5 LEU D 89 LYS D 93 5 5
HELIX 33 AD6 HIS D 142 PHE D 146 5 5
HELIX 34 AD7 GLU D 174 SER D 178 5 5
HELIX 35 AD8 ILE D 223 THR D 230 1 8
HELIX 36 AD9 THR D 230 GLN D 242 1 13
HELIX 37 AE1 VAL D 243 LEU D 247 5 5
HELIX 38 AE2 SER D 251 ASN D 275 1 25
HELIX 39 AE3 THR D 284 ASN D 308 1 25
HELIX 40 AE4 SER D 390 TYR D 415 1 26
HELIX 41 AE5 MET E 9 LYS E 18 1 10
HELIX 42 AE6 LYS E 70 ALA E 73 5 4
HELIX 43 AE7 ASP E 84 LEU E 91 5 8
HELIX 44 AE8 ASP E 139 TYR E 143 5 5
HELIX 45 AE9 GLY E 170 ALA E 174 5 5
HELIX 46 AF1 ILE E 218 THR E 225 1 8
HELIX 47 AF2 THR E 225 LEU E 235 1 11
HELIX 48 AF3 SER E 236 TRP E 241 5 6
HELIX 49 AF4 ALA E 246 GLU E 270 1 25
HELIX 50 AF5 LYS E 279 PHE E 307 1 29
HELIX 51 AF6 VAL E 420 TYR E 446 1 27
HELIX 52 AF7 ARG G 492 THR G 496 5 5
HELIX 53 AF8 THR G 512 TYR G 516 5 5
SHEET 1 A 6 VAL A 167 TRP A 171 0
SHEET 2 A 6 THR A 39 SER A 49 1
SHEET 3 A 6 GLU A 59 LYS A 71 -1
SHEET 4 A 6 THR A 126 GLU A 138 -1
SHEET 5 A 6 LYS A 117 THR A 122 -1
SHEET 6 A 6 VAL A 83 LEU A 86 -1
SHEET 1 B 2 ILE A 45 VAL A 47 0
SHEET 2 B 2 VAL A 179 VAL A 181 1
SHEET 1 C 4 THR A 99 PHE A 101 0
SHEET 2 C 4 ALA A 150 SER A 159 -1
SHEET 3 C 4 VAL A 211 LYS A 220 -1
SHEET 4 C 4 LEU A 193 ILE A 202 -1
SHEET 1 D 5 ILE B 164 TRP B 168 0
SHEET 2 D 5 VAL B 36 ILE B 47 1
SHEET 3 D 5 TYR B 57 ARG B 68 -1
SHEET 4 D 5 THR B 123 ALA B 134 -1
SHEET 5 D 5 ILE B 116 LEU B 118 -1
SHEET 1 E 4 THR B 96 PHE B 98 0
SHEET 2 E 4 GLU B 147 SER B 156 -1
SHEET 3 E 4 ALA B 204 ARG B 216 -1
SHEET 4 E 4 PHE B 186 VAL B 199 -1
SHEET 1 F 2 ASP B 101 VAL B 106 0
SHEET 2 F 2 ILE B 130 ALA B 134 -1
SHEET 1 G 6 ILE C 179 TRP C 183 0
SHEET 2 G 6 THR C 51 ILE C 62 1
SHEET 3 G 6 GLU C 71 TYR C 83 -1
SHEET 4 G 6 ARG C 138 GLU C 150 -1
SHEET 5 G 6 ARG C 129 TRP C 134 -1
SHEET 6 G 6 VAL C 95 LEU C 98 -1
SHEET 1 H 2 MET C 57 VAL C 59 0
SHEET 2 H 2 VAL C 188 VAL C 190 1
SHEET 1 I 4 THR C 111 PHE C 113 0
SHEET 2 I 4 HIS C 163 SER C 171 -1
SHEET 3 I 4 ASP C 219 ARG C 231 -1
SHEET 4 I 4 PHE C 201 LYS C 214 -1
SHEET 1 J 2 SER C 116 ALA C 121 0
SHEET 2 J 2 LEU C 145 ALA C 149 -1
SHEET 1 K 6 VAL D 167 TRP D 171 0
SHEET 2 K 6 THR D 39 SER D 49 1
SHEET 3 K 6 GLU D 59 LYS D 71 -1
SHEET 4 K 6 THR D 126 GLU D 138 -1
SHEET 5 K 6 LYS D 117 ILE D 121 -1
SHEET 6 K 6 LEU D 84 LEU D 86 -1
SHEET 1 L 3 ALA D 150 GLY D 158 0
SHEET 2 L 3 VAL D 212 ARG D 221 -1
SHEET 3 L 3 TYR D 191 LEU D 193 -1
SHEET 1 M 2 GLN D 196 SER D 205 0
SHEET 2 M 2 GLY D 208 PHE D 217 -1
SHEET 1 N 6 ILE E 164 TRP E 168 0
SHEET 2 N 6 VAL E 36 ILE E 47 1
SHEET 3 N 6 ASP E 56 ARG E 68 -1
SHEET 4 N 6 THR E 123 ALA E 135 -1
SHEET 5 N 6 ARG E 114 LEU E 118 -1
SHEET 6 N 6 LEU E 81 LEU E 83 -1
SHEET 1 O 4 THR E 96 PHE E 98 0
SHEET 2 O 4 GLU E 147 SER E 156 -1
SHEET 3 O 4 ALA E 204 LYS E 215 -1
SHEET 4 O 4 ILE E 188 VAL E 199 -1
SHEET 1 P 4 GLN G 5 SER G 7 0
SHEET 2 P 4 LEU G 424 ALA G 429 -1
SHEET 3 P 4 SER G 483 LEU G 488 -1
SHEET 4 P 4 THR G 474 ASP G 478 -1
SHEET 1 Q 4 VAL G 498 GLY G 504 0
SHEET 2 Q 4 ILE G 439 ALA G 446 -1
SHEET 3 Q 4 GLU G 450 MET G 457 -1
SHEET 4 Q 4 GLN G 463 TYR G 465 -1
SSBOND 1 CYS A 139 CYS A 153 1555 1555 2.03
SSBOND 2 CYS B 136 CYS B 150 1555 1555 2.04
SSBOND 3 CYS C 151 CYS C 165 1555 1555 2.04
SSBOND 4 CYS D 139 CYS D 153 1555 1555 2.03
SSBOND 5 CYS E 136 CYS E 150 1555 1555 2.03
SSBOND 6 CYS G 428 CYS G 501 1555 1555 2.03
LINK ND2 ASN A 111 C1 NAG F 1 1555 1555 1.48
LINK ND2 ASN B 80 C1 NAG H 1 1555 1555 1.44
LINK ND2 ASN B 149 C1 NAG I 1 1555 1555 1.44
LINK ND2 ASN C 208 C1 NAG J 1 1555 1555 1.44
LINK ND2 ASN D 111 C1 NAG K 1 1555 1555 1.44
LINK ND2 ASN E 80 C1 NAG L 1 1555 1555 1.45
LINK ND2 ASN E 149 C1 NAG M 1 1555 1555 1.41
LINK O4 NAG F 1 C1 NAG F 2 1555 1555 1.46
LINK O4 NAG F 2 C1 BMA F 3 1555 1555 1.41
LINK O6 BMA F 3 C1 MAN F 4 1555 1555 1.11
LINK O3 BMA F 3 C1 MAN F 7 1555 1555 1.36
LINK O3 MAN F 4 C1 MAN F 5 1555 1555 1.38
LINK O6 MAN F 4 C1 MAN F 6 1555 1555 1.38
LINK O4 NAG H 1 C1 NAG H 2 1555 1555 1.38
LINK O4 NAG I 1 C1 NAG I 2 1555 1555 1.38
LINK O4 NAG I 2 C1 BMA I 3 1555 1555 1.38
LINK O6 BMA I 3 C1 MAN I 4 1555 1555 1.38
LINK O3 BMA I 3 C1 MAN I 6 1555 1555 1.38
LINK O3 MAN I 4 C1 MAN I 5 1555 1555 1.38
LINK O4 NAG J 1 C1 NAG J 2 1555 1555 1.38
LINK O4 NAG K 1 C1 NAG K 2 1555 1555 1.38
LINK O4 NAG K 2 C1 BMA K 3 1555 1555 1.38
LINK O3 BMA K 3 C1 MAN K 4 1555 1555 1.38
LINK O6 BMA K 3 C1 MAN K 5 1555 1555 1.38
LINK O4 NAG L 1 C1 NAG L 2 1555 1555 1.37
LINK O4 NAG M 1 C1 NAG M 2 1555 1555 1.39
LINK O4 NAG M 2 C1 BMA M 3 1555 1555 1.38
LINK O6 BMA M 3 C1 MAN M 4 1555 1555 1.38
LINK O3 BMA M 3 C1 MAN M 6 1555 1555 1.38
LINK O3 MAN M 4 C1 MAN M 5 1555 1555 1.38
CISPEP 1 MET A 112 THR A 113 0 1.08
CISPEP 2 PHE A 146 PRO A 147 0 1.24
CISPEP 3 VAL B 109 THR B 110 0 3.22
CISPEP 4 TYR B 143 PRO B 144 0 -6.98
CISPEP 5 ILE C 124 THR C 125 0 6.99
CISPEP 6 PHE C 158 PRO C 159 0 -3.31
CISPEP 7 MET D 112 THR D 113 0 -1.31
CISPEP 8 PHE D 146 PRO D 147 0 -2.41
CISPEP 9 VAL E 109 THR E 110 0 8.10
CISPEP 10 TYR E 143 PRO E 144 0 1.40
CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 1
ORIGX1 1.000000 0.000000 0.000000 0.00000
ORIGX2 0.000000 1.000000 0.000000 0.00000
ORIGX3 0.000000 0.000000 1.000000 0.00000
SCALE1 1.000000 0.000000 0.000000 0.00000
SCALE2 0.000000 1.000000 0.000000 0.00000
SCALE3 0.000000 0.000000 1.000000 0.00000
(ATOM LINES ARE NOT SHOWN.)
END