GenomeNet

Database: PDB
Entry: 6J8E
LinkDB: 6J8E
Original site: 6J8E 
HEADER    MEMBRANE PROTEIN/TOXIN                  18-JAN-19   6J8E              
TITLE     HUMAN NAV1.2-BETA2-KIIIA TERNARY COMPLEX                              
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: SODIUM CHANNEL SUBUNIT BETA-2;                             
COMPND   3 CHAIN: C;                                                            
COMPND   4 ENGINEERED: YES;                                                     
COMPND   5 MOL_ID: 2;                                                           
COMPND   6 MOLECULE: SODIUM CHANNEL PROTEIN TYPE 2 SUBUNIT ALPHA;               
COMPND   7 CHAIN: A;                                                            
COMPND   8 SYNONYM: HBSC II,SODIUM CHANNEL PROTEIN BRAIN II SUBUNIT ALPHA,SODIUM
COMPND   9 CHANNEL PROTEIN TYPE II SUBUNIT ALPHA,VOLTAGE-GATED SODIUM CHANNEL   
COMPND  10 SUBUNIT ALPHA NAV1.2;                                                
COMPND  11 ENGINEERED: YES;                                                     
COMPND  12 MOL_ID: 3;                                                           
COMPND  13 MOLECULE: MU-CONOTOXIN KIIIA;                                        
COMPND  14 CHAIN: D;                                                            
COMPND  15 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   3 ORGANISM_COMMON: HUMAN;                                              
SOURCE   4 ORGANISM_TAXID: 9606;                                                
SOURCE   5 GENE: SCN2B, UNQ326/PRO386;                                          
SOURCE   6 EXPRESSION_SYSTEM: HOMO SAPIENS;                                     
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 9606;                                       
SOURCE   8 MOL_ID: 2;                                                           
SOURCE   9 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  10 ORGANISM_COMMON: HUMAN;                                              
SOURCE  11 ORGANISM_TAXID: 9606;                                                
SOURCE  12 GENE: SCN2A, NAC2, SCN2A1, SCN2A2;                                   
SOURCE  13 EXPRESSION_SYSTEM: HOMO SAPIENS;                                     
SOURCE  14 EXPRESSION_SYSTEM_TAXID: 9606;                                       
SOURCE  15 MOL_ID: 3;                                                           
SOURCE  16 SYNTHETIC: YES;                                                      
SOURCE  17 ORGANISM_SCIENTIFIC: CONUS KINOSHITAI;                               
SOURCE  18 ORGANISM_COMMON: KINOSHITA'S CONE;                                   
SOURCE  19 ORGANISM_TAXID: 376876                                               
KEYWDS    TRANSMEMBRANE PROTEIN, MEMBRANE PROTEIN, MEMBRANE PROTEIN-TOXIN       
KEYWDS   2 COMPLEX                                                              
EXPDTA    ELECTRON MICROSCOPY                                                   
AUTHOR    X.PAN,Z.LI,X.HUANG,G.HUANG,N.YAN                                      
REVDAT   3   06-NOV-19 6J8E    1       CRYST1                                   
REVDAT   2   10-APR-19 6J8E    1       JRNL                                     
REVDAT   1   27-FEB-19 6J8E    0                                                
JRNL        AUTH   X.PAN,Z.LI,X.HUANG,G.HUANG,S.GAO,H.SHEN,L.LIU,J.LEI,N.YAN    
JRNL        TITL   MOLECULAR BASIS FOR PORE BLOCKADE OF HUMAN NA+CHANNEL NAV1.2 
JRNL        TITL 2 BY THE MU-CONOTOXIN KIIIA.                                   
JRNL        REF    SCIENCE                       V. 363  1309 2019              
JRNL        REFN                   ESSN 1095-9203                               
JRNL        PMID   30765605                                                     
JRNL        DOI    10.1126/SCIENCE.AAW2999                                      
REMARK   2                                                                      
REMARK   2 RESOLUTION.    3.00 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   SOFTWARE PACKAGES      : NULL                                      
REMARK   3   RECONSTRUCTION SCHEMA  : NULL                                      
REMARK   3                                                                      
REMARK   3 EM MAP-MODEL FITTING AND REFINEMENT                                  
REMARK   3   PDB ENTRY                    : NULL                                
REMARK   3   REFINEMENT SPACE             : NULL                                
REMARK   3   REFINEMENT PROTOCOL          : NULL                                
REMARK   3   REFINEMENT TARGET            : NULL                                
REMARK   3   OVERALL ANISOTROPIC B VALUE  : NULL                                
REMARK   3                                                                      
REMARK   3 FITTING PROCEDURE : NULL                                             
REMARK   3                                                                      
REMARK   3 EM IMAGE RECONSTRUCTION STATISTICS                                   
REMARK   3   NOMINAL PIXEL SIZE (ANGSTROMS)    : NULL                           
REMARK   3   ACTUAL PIXEL SIZE  (ANGSTROMS)    : NULL                           
REMARK   3   EFFECTIVE RESOLUTION (ANGSTROMS)  : 3.000                          
REMARK   3   NUMBER OF PARTICLES               : 200275                         
REMARK   3   CTF CORRECTION METHOD             : PHASE FLIPPING ONLY            
REMARK   3                                                                      
REMARK   3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL                    
REMARK   3                                                                      
REMARK   3 OTHER DETAILS: NULL                                                  
REMARK   4                                                                      
REMARK   4 6J8E COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ ON 31-JAN-19.                  
REMARK 100 THE DEPOSITION ID IS D_1300010632.                                   
REMARK 245                                                                      
REMARK 245 EXPERIMENTAL DETAILS                                                 
REMARK 245   RECONSTRUCTION METHOD          : SINGLE PARTICLE                   
REMARK 245   SPECIMEN TYPE                  : NULL                              
REMARK 245                                                                      
REMARK 245 ELECTRON MICROSCOPE SAMPLE                                           
REMARK 245   SAMPLE TYPE                    : PARTICLE                          
REMARK 245   PARTICLE TYPE                  : POINT                             
REMARK 245   NAME OF SAMPLE                 : TERNARY COMPLEX OF NAV1.2-BETA2   
REMARK 245                                    -KIIIA; NAV1.2-BETA2; KIIIA       
REMARK 245   SAMPLE CONCENTRATION (MG ML-1) : 1.00                              
REMARK 245   SAMPLE SUPPORT DETAILS         : NULL                              
REMARK 245   SAMPLE VITRIFICATION DETAILS   : NULL                              
REMARK 245   SAMPLE BUFFER                  : NULL                              
REMARK 245   PH                             : 5.90                              
REMARK 245   SAMPLE DETAILS                 : NULL                              
REMARK 245                                                                      
REMARK 245 DATA ACQUISITION                                                     
REMARK 245   DATE OF EXPERIMENT                : NULL                           
REMARK 245   NUMBER OF MICROGRAPHS-IMAGES      : NULL                           
REMARK 245   TEMPERATURE (KELVIN)              : NULL                           
REMARK 245   MICROSCOPE MODEL                  : FEI TITAN KRIOS                
REMARK 245   DETECTOR TYPE                     : GATAN K2 QUANTUM (4K X 4K)     
REMARK 245   MINIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MAXIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MINIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   MAXIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   NOMINAL CS                        : NULL                           
REMARK 245   IMAGING MODE                      : BRIGHT FIELD                   
REMARK 245   ELECTRON DOSE (ELECTRONS NM**-2)  : 48.00                          
REMARK 245   ILLUMINATION MODE                 : FLOOD BEAM                     
REMARK 245   NOMINAL MAGNIFICATION             : NULL                           
REMARK 245   CALIBRATED MAGNIFICATION          : NULL                           
REMARK 245   SOURCE                            : FIELD EMISSION GUN             
REMARK 245   ACCELERATION VOLTAGE (KV)         : 300                            
REMARK 245   IMAGING DETAILS                   : NULL                           
REMARK 247                                                                      
REMARK 247 ELECTRON MICROSCOPY                                                  
REMARK 247  THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON          
REMARK 247  MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE              
REMARK 247  THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES           
REMARK 247  ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION         
REMARK 247  OF THE STRUCTURE FACTORS.                                           
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TRIMERIC                          
REMARK 350 APPLY THE FOLLOWING TO CHAINS: C, A, D                               
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     MET A   -42                                                      
REMARK 465     ALA A   -41                                                      
REMARK 465     SER A   -40                                                      
REMARK 465     TRP A   -39                                                      
REMARK 465     SER A   -38                                                      
REMARK 465     HIS A   -37                                                      
REMARK 465     PRO A   -36                                                      
REMARK 465     GLN A   -35                                                      
REMARK 465     PHE A   -34                                                      
REMARK 465     GLU A   -33                                                      
REMARK 465     LYS A   -32                                                      
REMARK 465     GLY A   -31                                                      
REMARK 465     GLY A   -30                                                      
REMARK 465     GLY A   -29                                                      
REMARK 465     ALA A   -28                                                      
REMARK 465     ARG A   -27                                                      
REMARK 465     GLY A   -26                                                      
REMARK 465     GLY A   -25                                                      
REMARK 465     SER A   -24                                                      
REMARK 465     GLY A   -23                                                      
REMARK 465     GLY A   -22                                                      
REMARK 465     GLY A   -21                                                      
REMARK 465     SER A   -20                                                      
REMARK 465     TRP A   -19                                                      
REMARK 465     SER A   -18                                                      
REMARK 465     HIS A   -17                                                      
REMARK 465     PRO A   -16                                                      
REMARK 465     GLN A   -15                                                      
REMARK 465     PHE A   -14                                                      
REMARK 465     GLU A   -13                                                      
REMARK 465     LYS A   -12                                                      
REMARK 465     GLY A   -11                                                      
REMARK 465     PHE A   -10                                                      
REMARK 465     ASP A    -9                                                      
REMARK 465     TYR A    -8                                                      
REMARK 465     LYS A    -7                                                      
REMARK 465     ASP A    -6                                                      
REMARK 465     ASP A    -5                                                      
REMARK 465     ASP A    -4                                                      
REMARK 465     ASP A    -3                                                      
REMARK 465     LYS A    -2                                                      
REMARK 465     GLY A    -1                                                      
REMARK 465     THR A     0                                                      
REMARK 465     MET A     1                                                      
REMARK 465     ALA A     2                                                      
REMARK 465     GLN A     3                                                      
REMARK 465     SER A     4                                                      
REMARK 465     VAL A     5                                                      
REMARK 465     LEU A     6                                                      
REMARK 465     VAL A     7                                                      
REMARK 465     PRO A     8                                                      
REMARK 465     PRO A     9                                                      
REMARK 465     GLY A    10                                                      
REMARK 465     PRO A    11                                                      
REMARK 465     ASP A    12                                                      
REMARK 465     SER A    13                                                      
REMARK 465     PHE A    14                                                      
REMARK 465     ARG A    15                                                      
REMARK 465     PHE A    16                                                      
REMARK 465     PHE A    17                                                      
REMARK 465     THR A    18                                                      
REMARK 465     ARG A    19                                                      
REMARK 465     GLU A    20                                                      
REMARK 465     SER A    21                                                      
REMARK 465     LEU A    22                                                      
REMARK 465     ALA A    23                                                      
REMARK 465     ALA A    24                                                      
REMARK 465     ILE A    25                                                      
REMARK 465     GLU A    26                                                      
REMARK 465     GLN A    27                                                      
REMARK 465     ARG A    28                                                      
REMARK 465     ILE A    29                                                      
REMARK 465     ALA A    30                                                      
REMARK 465     GLU A    31                                                      
REMARK 465     GLU A    32                                                      
REMARK 465     LYS A    33                                                      
REMARK 465     ALA A    34                                                      
REMARK 465     LYS A    35                                                      
REMARK 465     ARG A    36                                                      
REMARK 465     PRO A    37                                                      
REMARK 465     LYS A    38                                                      
REMARK 465     GLN A    39                                                      
REMARK 465     GLU A    40                                                      
REMARK 465     ARG A    41                                                      
REMARK 465     LYS A    42                                                      
REMARK 465     ASP A    43                                                      
REMARK 465     GLU A    44                                                      
REMARK 465     ASP A    45                                                      
REMARK 465     ASP A    46                                                      
REMARK 465     GLU A    47                                                      
REMARK 465     ASN A    48                                                      
REMARK 465     GLY A    49                                                      
REMARK 465     PRO A    50                                                      
REMARK 465     LYS A    51                                                      
REMARK 465     PRO A    52                                                      
REMARK 465     ASN A    53                                                      
REMARK 465     SER A    54                                                      
REMARK 465     ASP A    55                                                      
REMARK 465     LEU A    56                                                      
REMARK 465     GLU A    57                                                      
REMARK 465     ALA A    58                                                      
REMARK 465     GLY A    59                                                      
REMARK 465     LYS A    60                                                      
REMARK 465     SER A    61                                                      
REMARK 465     LEU A    62                                                      
REMARK 465     PRO A    63                                                      
REMARK 465     PHE A    64                                                      
REMARK 465     ILE A    65                                                      
REMARK 465     TYR A    66                                                      
REMARK 465     GLY A    67                                                      
REMARK 465     ASP A    68                                                      
REMARK 465     ILE A    69                                                      
REMARK 465     PRO A    70                                                      
REMARK 465     PRO A    71                                                      
REMARK 465     GLU A    72                                                      
REMARK 465     MET A    73                                                      
REMARK 465     VAL A    74                                                      
REMARK 465     SER A    75                                                      
REMARK 465     VAL A    76                                                      
REMARK 465     PRO A    77                                                      
REMARK 465     LEU A    78                                                      
REMARK 465     GLU A    79                                                      
REMARK 465     ASP A    80                                                      
REMARK 465     LEU A    81                                                      
REMARK 465     ASP A    82                                                      
REMARK 465     PRO A    83                                                      
REMARK 465     TYR A    84                                                      
REMARK 465     TYR A    85                                                      
REMARK 465     ILE A    86                                                      
REMARK 465     ASN A    87                                                      
REMARK 465     LYS A    88                                                      
REMARK 465     LYS A    89                                                      
REMARK 465     THR A    90                                                      
REMARK 465     PHE A    91                                                      
REMARK 465     ILE A    92                                                      
REMARK 465     VAL A    93                                                      
REMARK 465     LEU A    94                                                      
REMARK 465     ASN A    95                                                      
REMARK 465     LYS A    96                                                      
REMARK 465     GLY A    97                                                      
REMARK 465     LYS A    98                                                      
REMARK 465     ALA A    99                                                      
REMARK 465     ILE A   100                                                      
REMARK 465     SER A   101                                                      
REMARK 465     ARG A   102                                                      
REMARK 465     PHE A   103                                                      
REMARK 465     SER A   104                                                      
REMARK 465     ALA A   105                                                      
REMARK 465     THR A   106                                                      
REMARK 465     PRO A   107                                                      
REMARK 465     ALA A   108                                                      
REMARK 465     LEU A   109                                                      
REMARK 465     TYR A   110                                                      
REMARK 465     ILE A   111                                                      
REMARK 465     LEU A   112                                                      
REMARK 465     THR A   113                                                      
REMARK 465     PRO A   114                                                      
REMARK 465     PHE A   115                                                      
REMARK 465     ASN A   116                                                      
REMARK 465     ASN A   285                                                      
REMARK 465     SER A   286                                                      
REMARK 465     SER A   287                                                      
REMARK 465     PHE A   288                                                      
REMARK 465     GLU A   289                                                      
REMARK 465     ILE A   290                                                      
REMARK 465     ASN A   291                                                      
REMARK 465     ILE A   292                                                      
REMARK 465     THR A   293                                                      
REMARK 465     SER A   294                                                      
REMARK 465     PHE A   295                                                      
REMARK 465     PHE A   296                                                      
REMARK 465     ASN A   297                                                      
REMARK 465     ASN A   298                                                      
REMARK 465     SER A   299                                                      
REMARK 465     LEU A   300                                                      
REMARK 465     ASP A   301                                                      
REMARK 465     GLY A   302                                                      
REMARK 465     ASN A   303                                                      
REMARK 465     GLY A   304                                                      
REMARK 465     THR A   305                                                      
REMARK 465     THR A   306                                                      
REMARK 465     PHE A   307                                                      
REMARK 465     ASN A   308                                                      
REMARK 465     ARG A   309                                                      
REMARK 465     THR A   310                                                      
REMARK 465     VAL A   311                                                      
REMARK 465     SER A   312                                                      
REMARK 465     ILE A   313                                                      
REMARK 465     LYS A   442                                                      
REMARK 465     GLU A   443                                                      
REMARK 465     ALA A   444                                                      
REMARK 465     GLU A   445                                                      
REMARK 465     PHE A   446                                                      
REMARK 465     GLN A   447                                                      
REMARK 465     GLN A   448                                                      
REMARK 465     MET A   449                                                      
REMARK 465     LEU A   450                                                      
REMARK 465     GLU A   451                                                      
REMARK 465     GLN A   452                                                      
REMARK 465     LEU A   453                                                      
REMARK 465     LYS A   454                                                      
REMARK 465     LYS A   455                                                      
REMARK 465     GLN A   456                                                      
REMARK 465     GLN A   457                                                      
REMARK 465     GLU A   458                                                      
REMARK 465     GLU A   459                                                      
REMARK 465     ALA A   460                                                      
REMARK 465     GLN A   461                                                      
REMARK 465     ALA A   462                                                      
REMARK 465     ALA A   463                                                      
REMARK 465     ALA A   464                                                      
REMARK 465     ALA A   465                                                      
REMARK 465     ALA A   466                                                      
REMARK 465     ALA A   467                                                      
REMARK 465     SER A   468                                                      
REMARK 465     ALA A   469                                                      
REMARK 465     GLU A   470                                                      
REMARK 465     SER A   471                                                      
REMARK 465     ARG A   472                                                      
REMARK 465     ASP A   473                                                      
REMARK 465     PHE A   474                                                      
REMARK 465     SER A   475                                                      
REMARK 465     GLY A   476                                                      
REMARK 465     ALA A   477                                                      
REMARK 465     GLY A   478                                                      
REMARK 465     GLY A   479                                                      
REMARK 465     ILE A   480                                                      
REMARK 465     GLY A   481                                                      
REMARK 465     VAL A   482                                                      
REMARK 465     PHE A   483                                                      
REMARK 465     SER A   484                                                      
REMARK 465     GLU A   485                                                      
REMARK 465     SER A   486                                                      
REMARK 465     SER A   487                                                      
REMARK 465     SER A   488                                                      
REMARK 465     VAL A   489                                                      
REMARK 465     ALA A   490                                                      
REMARK 465     SER A   491                                                      
REMARK 465     LYS A   492                                                      
REMARK 465     LEU A   493                                                      
REMARK 465     SER A   494                                                      
REMARK 465     SER A   495                                                      
REMARK 465     LYS A   496                                                      
REMARK 465     SER A   497                                                      
REMARK 465     GLU A   498                                                      
REMARK 465     LYS A   499                                                      
REMARK 465     GLU A   500                                                      
REMARK 465     LEU A   501                                                      
REMARK 465     LYS A   502                                                      
REMARK 465     ASN A   503                                                      
REMARK 465     ARG A   504                                                      
REMARK 465     ARG A   505                                                      
REMARK 465     LYS A   506                                                      
REMARK 465     LYS A   507                                                      
REMARK 465     LYS A   508                                                      
REMARK 465     LYS A   509                                                      
REMARK 465     GLN A   510                                                      
REMARK 465     LYS A   511                                                      
REMARK 465     GLU A   512                                                      
REMARK 465     GLN A   513                                                      
REMARK 465     SER A   514                                                      
REMARK 465     GLY A   515                                                      
REMARK 465     GLU A   516                                                      
REMARK 465     GLU A   517                                                      
REMARK 465     GLU A   518                                                      
REMARK 465     LYS A   519                                                      
REMARK 465     ASN A   520                                                      
REMARK 465     ASP A   521                                                      
REMARK 465     ARG A   522                                                      
REMARK 465     VAL A   523                                                      
REMARK 465     ARG A   524                                                      
REMARK 465     LYS A   525                                                      
REMARK 465     SER A   526                                                      
REMARK 465     GLU A   527                                                      
REMARK 465     SER A   528                                                      
REMARK 465     GLU A   529                                                      
REMARK 465     ASP A   530                                                      
REMARK 465     SER A   531                                                      
REMARK 465     ILE A   532                                                      
REMARK 465     ARG A   533                                                      
REMARK 465     ARG A   534                                                      
REMARK 465     LYS A   535                                                      
REMARK 465     GLY A   536                                                      
REMARK 465     PHE A   537                                                      
REMARK 465     ARG A   538                                                      
REMARK 465     PHE A   539                                                      
REMARK 465     SER A   540                                                      
REMARK 465     LEU A   541                                                      
REMARK 465     GLU A   542                                                      
REMARK 465     GLY A   543                                                      
REMARK 465     SER A   544                                                      
REMARK 465     ARG A   545                                                      
REMARK 465     LEU A   546                                                      
REMARK 465     THR A   547                                                      
REMARK 465     TYR A   548                                                      
REMARK 465     GLU A   549                                                      
REMARK 465     LYS A   550                                                      
REMARK 465     ARG A   551                                                      
REMARK 465     PHE A   552                                                      
REMARK 465     SER A   553                                                      
REMARK 465     SER A   554                                                      
REMARK 465     PRO A   555                                                      
REMARK 465     HIS A   556                                                      
REMARK 465     GLN A   557                                                      
REMARK 465     SER A   558                                                      
REMARK 465     LEU A   559                                                      
REMARK 465     LEU A   560                                                      
REMARK 465     SER A   561                                                      
REMARK 465     ILE A   562                                                      
REMARK 465     ARG A   563                                                      
REMARK 465     GLY A   564                                                      
REMARK 465     SER A   565                                                      
REMARK 465     LEU A   566                                                      
REMARK 465     PHE A   567                                                      
REMARK 465     SER A   568                                                      
REMARK 465     PRO A   569                                                      
REMARK 465     ARG A   570                                                      
REMARK 465     ARG A   571                                                      
REMARK 465     ASN A   572                                                      
REMARK 465     SER A   573                                                      
REMARK 465     ARG A   574                                                      
REMARK 465     ALA A   575                                                      
REMARK 465     SER A   576                                                      
REMARK 465     LEU A   577                                                      
REMARK 465     PHE A   578                                                      
REMARK 465     SER A   579                                                      
REMARK 465     PHE A   580                                                      
REMARK 465     ARG A   581                                                      
REMARK 465     GLY A   582                                                      
REMARK 465     ARG A   583                                                      
REMARK 465     ALA A   584                                                      
REMARK 465     LYS A   585                                                      
REMARK 465     ASP A   586                                                      
REMARK 465     ILE A   587                                                      
REMARK 465     GLY A   588                                                      
REMARK 465     SER A   589                                                      
REMARK 465     GLU A   590                                                      
REMARK 465     ASN A   591                                                      
REMARK 465     ASP A   592                                                      
REMARK 465     PHE A   593                                                      
REMARK 465     ALA A   594                                                      
REMARK 465     ASP A   595                                                      
REMARK 465     ASP A   596                                                      
REMARK 465     GLU A   597                                                      
REMARK 465     HIS A   598                                                      
REMARK 465     SER A   599                                                      
REMARK 465     THR A   600                                                      
REMARK 465     PHE A   601                                                      
REMARK 465     GLU A   602                                                      
REMARK 465     ASP A   603                                                      
REMARK 465     ASN A   604                                                      
REMARK 465     ASP A   605                                                      
REMARK 465     SER A   606                                                      
REMARK 465     ARG A   607                                                      
REMARK 465     ARG A   608                                                      
REMARK 465     ASP A   609                                                      
REMARK 465     SER A   610                                                      
REMARK 465     LEU A   611                                                      
REMARK 465     PHE A   612                                                      
REMARK 465     VAL A   613                                                      
REMARK 465     PRO A   614                                                      
REMARK 465     HIS A   615                                                      
REMARK 465     ARG A   616                                                      
REMARK 465     HIS A   617                                                      
REMARK 465     GLY A   618                                                      
REMARK 465     GLU A   619                                                      
REMARK 465     ARG A   620                                                      
REMARK 465     ARG A   621                                                      
REMARK 465     HIS A   622                                                      
REMARK 465     SER A   623                                                      
REMARK 465     ASN A   624                                                      
REMARK 465     VAL A   625                                                      
REMARK 465     SER A   626                                                      
REMARK 465     GLN A   627                                                      
REMARK 465     ALA A   628                                                      
REMARK 465     SER A   629                                                      
REMARK 465     ARG A   630                                                      
REMARK 465     ALA A   631                                                      
REMARK 465     SER A   632                                                      
REMARK 465     ARG A   633                                                      
REMARK 465     VAL A   634                                                      
REMARK 465     LEU A   635                                                      
REMARK 465     PRO A   636                                                      
REMARK 465     ILE A   637                                                      
REMARK 465     LEU A   638                                                      
REMARK 465     PRO A   639                                                      
REMARK 465     MET A   640                                                      
REMARK 465     ASN A   641                                                      
REMARK 465     GLY A   642                                                      
REMARK 465     LYS A   643                                                      
REMARK 465     MET A   644                                                      
REMARK 465     HIS A   645                                                      
REMARK 465     SER A   646                                                      
REMARK 465     ALA A   647                                                      
REMARK 465     VAL A   648                                                      
REMARK 465     ASP A   649                                                      
REMARK 465     CYS A   650                                                      
REMARK 465     ASN A   651                                                      
REMARK 465     GLY A   652                                                      
REMARK 465     VAL A   653                                                      
REMARK 465     VAL A   654                                                      
REMARK 465     SER A   655                                                      
REMARK 465     LEU A   656                                                      
REMARK 465     VAL A   657                                                      
REMARK 465     GLY A   658                                                      
REMARK 465     GLY A   659                                                      
REMARK 465     PRO A   660                                                      
REMARK 465     SER A   661                                                      
REMARK 465     THR A   662                                                      
REMARK 465     LEU A   663                                                      
REMARK 465     THR A   664                                                      
REMARK 465     SER A   665                                                      
REMARK 465     ALA A   666                                                      
REMARK 465     GLY A   667                                                      
REMARK 465     GLN A   668                                                      
REMARK 465     LEU A   669                                                      
REMARK 465     LEU A   670                                                      
REMARK 465     PRO A   671                                                      
REMARK 465     GLU A   672                                                      
REMARK 465     GLY A   673                                                      
REMARK 465     THR A   674                                                      
REMARK 465     THR A   675                                                      
REMARK 465     THR A   676                                                      
REMARK 465     GLU A   677                                                      
REMARK 465     THR A   678                                                      
REMARK 465     GLU A   679                                                      
REMARK 465     ILE A   680                                                      
REMARK 465     ARG A   681                                                      
REMARK 465     LYS A   682                                                      
REMARK 465     ARG A   683                                                      
REMARK 465     ARG A   684                                                      
REMARK 465     SER A   685                                                      
REMARK 465     SER A   686                                                      
REMARK 465     SER A   687                                                      
REMARK 465     TYR A   688                                                      
REMARK 465     HIS A   689                                                      
REMARK 465     VAL A   690                                                      
REMARK 465     SER A   691                                                      
REMARK 465     MET A   692                                                      
REMARK 465     ASP A   693                                                      
REMARK 465     LEU A   694                                                      
REMARK 465     LEU A   695                                                      
REMARK 465     GLU A   696                                                      
REMARK 465     ASP A   697                                                      
REMARK 465     PRO A   698                                                      
REMARK 465     THR A   699                                                      
REMARK 465     SER A   700                                                      
REMARK 465     ARG A   701                                                      
REMARK 465     GLN A   702                                                      
REMARK 465     ARG A   703                                                      
REMARK 465     ALA A   704                                                      
REMARK 465     MET A   705                                                      
REMARK 465     SER A   706                                                      
REMARK 465     ILE A   707                                                      
REMARK 465     ALA A   708                                                      
REMARK 465     SER A   709                                                      
REMARK 465     ILE A   710                                                      
REMARK 465     LEU A   711                                                      
REMARK 465     THR A   712                                                      
REMARK 465     ASN A   713                                                      
REMARK 465     THR A   714                                                      
REMARK 465     MET A   715                                                      
REMARK 465     GLU A   716                                                      
REMARK 465     GLU A   717                                                      
REMARK 465     LEU A   718                                                      
REMARK 465     GLU A   719                                                      
REMARK 465     GLU A   720                                                      
REMARK 465     SER A   721                                                      
REMARK 465     ARG A   722                                                      
REMARK 465     GLN A   723                                                      
REMARK 465     LYS A   724                                                      
REMARK 465     CYS A   725                                                      
REMARK 465     PRO A   726                                                      
REMARK 465     PRO A   727                                                      
REMARK 465     CYS A   728                                                      
REMARK 465     TRP A   729                                                      
REMARK 465     TYR A   730                                                      
REMARK 465     LYS A   731                                                      
REMARK 465     PHE A   732                                                      
REMARK 465     ALA A   733                                                      
REMARK 465     ASN A   734                                                      
REMARK 465     MET A   735                                                      
REMARK 465     CYS A   736                                                      
REMARK 465     LEU A   737                                                      
REMARK 465     ILE A   738                                                      
REMARK 465     TRP A   739                                                      
REMARK 465     SER A   988                                                      
REMARK 465     ASP A   989                                                      
REMARK 465     ASN A   990                                                      
REMARK 465     LEU A   991                                                      
REMARK 465     ALA A   992                                                      
REMARK 465     ALA A   993                                                      
REMARK 465     THR A   994                                                      
REMARK 465     ASP A   995                                                      
REMARK 465     ASP A   996                                                      
REMARK 465     ASP A   997                                                      
REMARK 465     ASN A   998                                                      
REMARK 465     GLU A   999                                                      
REMARK 465     MET A  1000                                                      
REMARK 465     ASN A  1001                                                      
REMARK 465     ASN A  1002                                                      
REMARK 465     LEU A  1003                                                      
REMARK 465     GLN A  1004                                                      
REMARK 465     ILE A  1005                                                      
REMARK 465     ALA A  1006                                                      
REMARK 465     VAL A  1007                                                      
REMARK 465     GLY A  1008                                                      
REMARK 465     ARG A  1009                                                      
REMARK 465     MET A  1010                                                      
REMARK 465     GLN A  1011                                                      
REMARK 465     LYS A  1012                                                      
REMARK 465     GLY A  1013                                                      
REMARK 465     ILE A  1014                                                      
REMARK 465     ASP A  1015                                                      
REMARK 465     PHE A  1016                                                      
REMARK 465     VAL A  1017                                                      
REMARK 465     LYS A  1018                                                      
REMARK 465     ARG A  1019                                                      
REMARK 465     LYS A  1020                                                      
REMARK 465     ILE A  1021                                                      
REMARK 465     ARG A  1022                                                      
REMARK 465     GLU A  1023                                                      
REMARK 465     PHE A  1024                                                      
REMARK 465     ILE A  1025                                                      
REMARK 465     GLN A  1026                                                      
REMARK 465     LYS A  1027                                                      
REMARK 465     ALA A  1028                                                      
REMARK 465     PHE A  1029                                                      
REMARK 465     VAL A  1030                                                      
REMARK 465     ARG A  1031                                                      
REMARK 465     LYS A  1032                                                      
REMARK 465     GLN A  1033                                                      
REMARK 465     LYS A  1034                                                      
REMARK 465     ALA A  1035                                                      
REMARK 465     LEU A  1036                                                      
REMARK 465     ASP A  1037                                                      
REMARK 465     GLU A  1038                                                      
REMARK 465     ILE A  1039                                                      
REMARK 465     LYS A  1040                                                      
REMARK 465     PRO A  1041                                                      
REMARK 465     LEU A  1042                                                      
REMARK 465     GLU A  1043                                                      
REMARK 465     ASP A  1044                                                      
REMARK 465     LEU A  1045                                                      
REMARK 465     ASN A  1046                                                      
REMARK 465     ASN A  1047                                                      
REMARK 465     LYS A  1048                                                      
REMARK 465     LYS A  1049                                                      
REMARK 465     ASP A  1050                                                      
REMARK 465     SER A  1051                                                      
REMARK 465     CYS A  1052                                                      
REMARK 465     ILE A  1053                                                      
REMARK 465     SER A  1054                                                      
REMARK 465     ASN A  1055                                                      
REMARK 465     HIS A  1056                                                      
REMARK 465     THR A  1057                                                      
REMARK 465     THR A  1058                                                      
REMARK 465     ILE A  1059                                                      
REMARK 465     GLU A  1060                                                      
REMARK 465     ILE A  1061                                                      
REMARK 465     GLY A  1062                                                      
REMARK 465     LYS A  1063                                                      
REMARK 465     ASP A  1064                                                      
REMARK 465     LEU A  1065                                                      
REMARK 465     ASN A  1066                                                      
REMARK 465     TYR A  1067                                                      
REMARK 465     LEU A  1068                                                      
REMARK 465     LYS A  1069                                                      
REMARK 465     ASP A  1070                                                      
REMARK 465     GLY A  1071                                                      
REMARK 465     ASN A  1072                                                      
REMARK 465     GLY A  1073                                                      
REMARK 465     THR A  1074                                                      
REMARK 465     THR A  1075                                                      
REMARK 465     SER A  1076                                                      
REMARK 465     GLY A  1077                                                      
REMARK 465     ILE A  1078                                                      
REMARK 465     GLY A  1079                                                      
REMARK 465     SER A  1080                                                      
REMARK 465     SER A  1081                                                      
REMARK 465     VAL A  1082                                                      
REMARK 465     GLU A  1083                                                      
REMARK 465     LYS A  1084                                                      
REMARK 465     TYR A  1085                                                      
REMARK 465     VAL A  1086                                                      
REMARK 465     VAL A  1087                                                      
REMARK 465     ASP A  1088                                                      
REMARK 465     GLU A  1089                                                      
REMARK 465     SER A  1090                                                      
REMARK 465     ASP A  1091                                                      
REMARK 465     TYR A  1092                                                      
REMARK 465     MET A  1093                                                      
REMARK 465     SER A  1094                                                      
REMARK 465     PHE A  1095                                                      
REMARK 465     ILE A  1096                                                      
REMARK 465     ASN A  1097                                                      
REMARK 465     ASN A  1098                                                      
REMARK 465     PRO A  1099                                                      
REMARK 465     SER A  1100                                                      
REMARK 465     LEU A  1101                                                      
REMARK 465     THR A  1102                                                      
REMARK 465     VAL A  1103                                                      
REMARK 465     THR A  1104                                                      
REMARK 465     VAL A  1105                                                      
REMARK 465     PRO A  1106                                                      
REMARK 465     ILE A  1107                                                      
REMARK 465     ALA A  1108                                                      
REMARK 465     VAL A  1109                                                      
REMARK 465     GLY A  1110                                                      
REMARK 465     GLU A  1111                                                      
REMARK 465     SER A  1112                                                      
REMARK 465     ASP A  1113                                                      
REMARK 465     PHE A  1114                                                      
REMARK 465     GLU A  1115                                                      
REMARK 465     ASN A  1116                                                      
REMARK 465     LEU A  1117                                                      
REMARK 465     ASN A  1118                                                      
REMARK 465     THR A  1119                                                      
REMARK 465     GLU A  1120                                                      
REMARK 465     GLU A  1121                                                      
REMARK 465     PHE A  1122                                                      
REMARK 465     SER A  1123                                                      
REMARK 465     SER A  1124                                                      
REMARK 465     GLU A  1125                                                      
REMARK 465     SER A  1126                                                      
REMARK 465     ASP A  1127                                                      
REMARK 465     MET A  1128                                                      
REMARK 465     GLU A  1129                                                      
REMARK 465     GLU A  1130                                                      
REMARK 465     SER A  1131                                                      
REMARK 465     LYS A  1132                                                      
REMARK 465     GLU A  1133                                                      
REMARK 465     LYS A  1134                                                      
REMARK 465     LEU A  1135                                                      
REMARK 465     ASN A  1136                                                      
REMARK 465     ALA A  1137                                                      
REMARK 465     THR A  1138                                                      
REMARK 465     SER A  1139                                                      
REMARK 465     SER A  1140                                                      
REMARK 465     SER A  1141                                                      
REMARK 465     GLU A  1142                                                      
REMARK 465     GLY A  1143                                                      
REMARK 465     SER A  1144                                                      
REMARK 465     THR A  1145                                                      
REMARK 465     VAL A  1146                                                      
REMARK 465     ASP A  1147                                                      
REMARK 465     ILE A  1148                                                      
REMARK 465     GLY A  1149                                                      
REMARK 465     ALA A  1150                                                      
REMARK 465     PRO A  1151                                                      
REMARK 465     ALA A  1152                                                      
REMARK 465     GLU A  1153                                                      
REMARK 465     GLY A  1154                                                      
REMARK 465     GLU A  1155                                                      
REMARK 465     GLN A  1156                                                      
REMARK 465     PRO A  1157                                                      
REMARK 465     GLU A  1158                                                      
REMARK 465     VAL A  1159                                                      
REMARK 465     GLU A  1160                                                      
REMARK 465     PRO A  1161                                                      
REMARK 465     GLU A  1162                                                      
REMARK 465     GLU A  1163                                                      
REMARK 465     SER A  1164                                                      
REMARK 465     LEU A  1165                                                      
REMARK 465     GLU A  1166                                                      
REMARK 465     PRO A  1167                                                      
REMARK 465     GLU A  1168                                                      
REMARK 465     ALA A  1169                                                      
REMARK 465     CYS A  1170                                                      
REMARK 465     PHE A  1171                                                      
REMARK 465     THR A  1172                                                      
REMARK 465     GLU A  1173                                                      
REMARK 465     ASP A  1174                                                      
REMARK 465     CYS A  1175                                                      
REMARK 465     VAL A  1176                                                      
REMARK 465     ARG A  1177                                                      
REMARK 465     LYS A  1178                                                      
REMARK 465     PHE A  1179                                                      
REMARK 465     LYS A  1180                                                      
REMARK 465     CYS A  1181                                                      
REMARK 465     CYS A  1182                                                      
REMARK 465     GLN A  1183                                                      
REMARK 465     ILE A  1184                                                      
REMARK 465     SER A  1185                                                      
REMARK 465     ILE A  1186                                                      
REMARK 465     GLU A  1187                                                      
REMARK 465     GLU A  1188                                                      
REMARK 465     GLY A  1189                                                      
REMARK 465     LYS A  1190                                                      
REMARK 465     SER A  1786                                                      
REMARK 465     ALA A  1787                                                      
REMARK 465     GLU A  1788                                                      
REMARK 465     PRO A  1789                                                      
REMARK 465     LEU A  1790                                                      
REMARK 465     SER A  1791                                                      
REMARK 465     GLU A  1792                                                      
REMARK 465     ASP A  1793                                                      
REMARK 465     ASP A  1794                                                      
REMARK 465     PHE A  1795                                                      
REMARK 465     GLU A  1796                                                      
REMARK 465     MET A  1797                                                      
REMARK 465     PHE A  1798                                                      
REMARK 465     TYR A  1799                                                      
REMARK 465     GLU A  1800                                                      
REMARK 465     VAL A  1801                                                      
REMARK 465     TRP A  1802                                                      
REMARK 465     GLU A  1803                                                      
REMARK 465     LYS A  1804                                                      
REMARK 465     PHE A  1805                                                      
REMARK 465     ASP A  1806                                                      
REMARK 465     PRO A  1807                                                      
REMARK 465     ASP A  1808                                                      
REMARK 465     ALA A  1809                                                      
REMARK 465     THR A  1810                                                      
REMARK 465     GLN A  1811                                                      
REMARK 465     PHE A  1812                                                      
REMARK 465     ILE A  1813                                                      
REMARK 465     GLU A  1814                                                      
REMARK 465     PHE A  1815                                                      
REMARK 465     ALA A  1816                                                      
REMARK 465     LYS A  1817                                                      
REMARK 465     LEU A  1818                                                      
REMARK 465     SER A  1819                                                      
REMARK 465     ASP A  1820                                                      
REMARK 465     PHE A  1821                                                      
REMARK 465     ALA A  1822                                                      
REMARK 465     ASP A  1823                                                      
REMARK 465     ALA A  1824                                                      
REMARK 465     LEU A  1825                                                      
REMARK 465     ASP A  1826                                                      
REMARK 465     PRO A  1827                                                      
REMARK 465     PRO A  1828                                                      
REMARK 465     LEU A  1829                                                      
REMARK 465     LEU A  1830                                                      
REMARK 465     ILE A  1831                                                      
REMARK 465     ALA A  1832                                                      
REMARK 465     LYS A  1833                                                      
REMARK 465     PRO A  1834                                                      
REMARK 465     ASN A  1835                                                      
REMARK 465     LYS A  1836                                                      
REMARK 465     VAL A  1837                                                      
REMARK 465     GLN A  1838                                                      
REMARK 465     LEU A  1839                                                      
REMARK 465     ILE A  1840                                                      
REMARK 465     ALA A  1841                                                      
REMARK 465     MET A  1842                                                      
REMARK 465     ASP A  1843                                                      
REMARK 465     LEU A  1844                                                      
REMARK 465     PRO A  1845                                                      
REMARK 465     MET A  1846                                                      
REMARK 465     VAL A  1847                                                      
REMARK 465     SER A  1848                                                      
REMARK 465     GLY A  1849                                                      
REMARK 465     ASP A  1850                                                      
REMARK 465     ARG A  1851                                                      
REMARK 465     ILE A  1852                                                      
REMARK 465     HIS A  1853                                                      
REMARK 465     CYS A  1854                                                      
REMARK 465     LEU A  1855                                                      
REMARK 465     ASP A  1856                                                      
REMARK 465     ILE A  1857                                                      
REMARK 465     LEU A  1858                                                      
REMARK 465     PHE A  1859                                                      
REMARK 465     ALA A  1860                                                      
REMARK 465     PHE A  1861                                                      
REMARK 465     THR A  1862                                                      
REMARK 465     LYS A  1863                                                      
REMARK 465     ARG A  1864                                                      
REMARK 465     VAL A  1865                                                      
REMARK 465     LEU A  1866                                                      
REMARK 465     GLY A  1867                                                      
REMARK 465     GLU A  1868                                                      
REMARK 465     SER A  1869                                                      
REMARK 465     GLY A  1870                                                      
REMARK 465     GLU A  1871                                                      
REMARK 465     MET A  1872                                                      
REMARK 465     ASP A  1873                                                      
REMARK 465     ALA A  1874                                                      
REMARK 465     LEU A  1875                                                      
REMARK 465     ARG A  1876                                                      
REMARK 465     ILE A  1877                                                      
REMARK 465     GLN A  1878                                                      
REMARK 465     MET A  1879                                                      
REMARK 465     GLU A  1880                                                      
REMARK 465     GLU A  1881                                                      
REMARK 465     ARG A  1882                                                      
REMARK 465     PHE A  1883                                                      
REMARK 465     MET A  1884                                                      
REMARK 465     ALA A  1885                                                      
REMARK 465     SER A  1886                                                      
REMARK 465     ASN A  1887                                                      
REMARK 465     PRO A  1888                                                      
REMARK 465     SER A  1889                                                      
REMARK 465     LYS A  1890                                                      
REMARK 465     VAL A  1891                                                      
REMARK 465     SER A  1892                                                      
REMARK 465     TYR A  1893                                                      
REMARK 465     GLU A  1894                                                      
REMARK 465     PRO A  1895                                                      
REMARK 465     ILE A  1896                                                      
REMARK 465     THR A  1897                                                      
REMARK 465     THR A  1898                                                      
REMARK 465     THR A  1899                                                      
REMARK 465     LEU A  1900                                                      
REMARK 465     LYS A  1901                                                      
REMARK 465     ARG A  1902                                                      
REMARK 465     LYS A  1903                                                      
REMARK 465     GLN A  1904                                                      
REMARK 465     GLU A  1905                                                      
REMARK 465     GLU A  1906                                                      
REMARK 465     VAL A  1907                                                      
REMARK 465     SER A  1908                                                      
REMARK 465     ALA A  1909                                                      
REMARK 465     ILE A  1910                                                      
REMARK 465     ILE A  1911                                                      
REMARK 465     ILE A  1912                                                      
REMARK 465     GLN A  1913                                                      
REMARK 465     ARG A  1914                                                      
REMARK 465     ALA A  1915                                                      
REMARK 465     TYR A  1916                                                      
REMARK 465     ARG A  1917                                                      
REMARK 465     ARG A  1918                                                      
REMARK 465     TYR A  1919                                                      
REMARK 465     LEU A  1920                                                      
REMARK 465     LEU A  1921                                                      
REMARK 465     LYS A  1922                                                      
REMARK 465     GLN A  1923                                                      
REMARK 465     LYS A  1924                                                      
REMARK 465     VAL A  1925                                                      
REMARK 465     LYS A  1926                                                      
REMARK 465     LYS A  1927                                                      
REMARK 465     VAL A  1928                                                      
REMARK 465     SER A  1929                                                      
REMARK 465     SER A  1930                                                      
REMARK 465     ILE A  1931                                                      
REMARK 465     TYR A  1932                                                      
REMARK 465     LYS A  1933                                                      
REMARK 465     LYS A  1934                                                      
REMARK 465     ASP A  1935                                                      
REMARK 465     LYS A  1936                                                      
REMARK 465     GLY A  1937                                                      
REMARK 465     LYS A  1938                                                      
REMARK 465     GLU A  1939                                                      
REMARK 465     CYS A  1940                                                      
REMARK 465     ASP A  1941                                                      
REMARK 465     GLY A  1942                                                      
REMARK 465     THR A  1943                                                      
REMARK 465     PRO A  1944                                                      
REMARK 465     ILE A  1945                                                      
REMARK 465     LYS A  1946                                                      
REMARK 465     GLU A  1947                                                      
REMARK 465     ASP A  1948                                                      
REMARK 465     THR A  1949                                                      
REMARK 465     LEU A  1950                                                      
REMARK 465     ILE A  1951                                                      
REMARK 465     ASP A  1952                                                      
REMARK 465     LYS A  1953                                                      
REMARK 465     LEU A  1954                                                      
REMARK 465     ASN A  1955                                                      
REMARK 465     GLU A  1956                                                      
REMARK 465     ASN A  1957                                                      
REMARK 465     SER A  1958                                                      
REMARK 465     THR A  1959                                                      
REMARK 465     PRO A  1960                                                      
REMARK 465     GLU A  1961                                                      
REMARK 465     LYS A  1962                                                      
REMARK 465     THR A  1963                                                      
REMARK 465     ASP A  1964                                                      
REMARK 465     MET A  1965                                                      
REMARK 465     THR A  1966                                                      
REMARK 465     PRO A  1967                                                      
REMARK 465     SER A  1968                                                      
REMARK 465     THR A  1969                                                      
REMARK 465     THR A  1970                                                      
REMARK 465     SER A  1971                                                      
REMARK 465     PRO A  1972                                                      
REMARK 465     PRO A  1973                                                      
REMARK 465     SER A  1974                                                      
REMARK 465     TYR A  1975                                                      
REMARK 465     ASP A  1976                                                      
REMARK 465     SER A  1977                                                      
REMARK 465     VAL A  1978                                                      
REMARK 465     THR A  1979                                                      
REMARK 465     LYS A  1980                                                      
REMARK 465     PRO A  1981                                                      
REMARK 465     GLU A  1982                                                      
REMARK 465     LYS A  1983                                                      
REMARK 465     GLU A  1984                                                      
REMARK 465     LYS A  1985                                                      
REMARK 465     PHE A  1986                                                      
REMARK 465     GLU A  1987                                                      
REMARK 465     LYS A  1988                                                      
REMARK 465     ASP A  1989                                                      
REMARK 465     LYS A  1990                                                      
REMARK 465     SER A  1991                                                      
REMARK 465     GLU A  1992                                                      
REMARK 465     LYS A  1993                                                      
REMARK 465     GLU A  1994                                                      
REMARK 465     ASP A  1995                                                      
REMARK 465     LYS A  1996                                                      
REMARK 465     GLY A  1997                                                      
REMARK 465     LYS A  1998                                                      
REMARK 465     ASP A  1999                                                      
REMARK 465     ILE A  2000                                                      
REMARK 465     ARG A  2001                                                      
REMARK 465     GLU A  2002                                                      
REMARK 465     SER A  2003                                                      
REMARK 465     LYS A  2004                                                      
REMARK 465     LYS A  2005                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     MET C 148    CG   SD   CE                                        
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS                                      
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,2(A3,1X,A1,I4,A1,1X,A4,3X),1X,F6.3)               
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   RES CSSEQI ATM2   DEVIATION                     
REMARK 500    CYS C 127   CB    CYS C 127   SG      0.193                       
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500    GLU C  31   C   -  N   -  CA  ANGL. DEV. =  16.3 DEGREES          
REMARK 500    GLN C  96   CA  -  C   -  N   ANGL. DEV. = -21.2 DEGREES          
REMARK 500    GLN C  96   O   -  C   -  N   ANGL. DEV. =  20.0 DEGREES          
REMARK 500    ASP C  97   C   -  N   -  CA  ANGL. DEV. = -18.4 DEGREES          
REMARK 500    CYS C 127   CA  -  CB  -  SG  ANGL. DEV. =  13.9 DEGREES          
REMARK 500    GLY A 211   N   -  CA  -  C   ANGL. DEV. =  21.5 DEGREES          
REMARK 500    ASN A 212   N   -  CA  -  CB  ANGL. DEV. =  20.9 DEGREES          
REMARK 500    ASP A 343   CB  -  CG  -  OD1 ANGL. DEV. =   5.7 DEGREES          
REMARK 500    PRO A 744   C   -  N   -  CD  ANGL. DEV. = -33.8 DEGREES          
REMARK 500    ASP A1736   CB  -  CG  -  OD1 ANGL. DEV. =   5.8 DEGREES          
REMARK 500    SER D   5   CB  -  CA  -  C   ANGL. DEV. = -17.3 DEGREES          
REMARK 500    CYS D   9   CA  -  C   -  N   ANGL. DEV. =  13.8 DEGREES          
REMARK 500    CYS D   9   O   -  C   -  N   ANGL. DEV. = -15.1 DEGREES          
REMARK 500    ARG D  10   CA  -  C   -  O   ANGL. DEV. =  16.7 DEGREES          
REMARK 500    ARG D  10   CA  -  C   -  N   ANGL. DEV. = -14.6 DEGREES          
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    CYS C  50       95.96   -160.40                                   
REMARK 500    MET C  85      -36.08     74.34                                   
REMARK 500    GLN C  96     -175.86    112.86                                   
REMARK 500    SER C 102       30.21   -140.19                                   
REMARK 500    ASN C 104       93.71   -162.40                                   
REMARK 500    ILE A 118     -120.36     42.68                                   
REMARK 500    ILE A 123      -40.71   -141.79                                   
REMARK 500    CYS A 180       71.69     53.20                                   
REMARK 500    ASP A 183     -115.38     41.43                                   
REMARK 500    PHE A 184     -134.94   -126.97                                   
REMARK 500    THR A 185      -81.20   -152.02                                   
REMARK 500    PHE A 186       51.84   -104.67                                   
REMARK 500    PHE A 207       60.54   -118.07                                   
REMARK 500    VAL A 208      -90.57     50.07                                   
REMARK 500    LEU A 210      -51.37   -121.94                                   
REMARK 500    ASN A 212      -71.74     91.84                                   
REMARK 500    PHE A 270       76.44   -108.79                                   
REMARK 500    TRP A 316      -68.18     84.46                                   
REMARK 500    LYS A 323       -7.02     73.08                                   
REMARK 500    GLU A 330       57.72     36.67                                   
REMARK 500    ASN A 333       24.26     45.87                                   
REMARK 500    ALA A 335       79.94     58.05                                   
REMARK 500    LEU A 336      140.89    -38.53                                   
REMARK 500    ASP A 343       11.30     85.33                                   
REMARK 500    ARG A 358      -80.04    -86.55                                   
REMARK 500    ASN A 359      167.77    173.38                                   
REMARK 500    ASN A 361      -44.77     75.85                                   
REMARK 500    TYR A 362       20.95   -164.04                                   
REMARK 500    THR A 369       87.37    110.36                                   
REMARK 500    PHE A 370      -35.60    -29.37                                   
REMARK 500    GLN A 383       73.14     45.47                                   
REMARK 500    CYS A 741      -77.96    -66.94                                   
REMARK 500    HIS A 750      -48.87    -27.23                                   
REMARK 500    LEU A 754       49.97    -69.93                                   
REMARK 500    VAL A 756       50.72     39.07                                   
REMARK 500    ASP A 758      -41.84   -143.61                                   
REMARK 500    PHE A 760       47.21    -84.22                                   
REMARK 500    GLN A 786       -8.14     76.51                                   
REMARK 500    MET A 813       13.14   -140.99                                   
REMARK 500    ASP A 814       76.52     55.15                                   
REMARK 500    TYR A 816       52.67    -95.09                                   
REMARK 500    SER A 915      164.74    170.90                                   
REMARK 500    ALA A 954       10.21   -142.78                                   
REMARK 500    PHE A1359     -147.69   -126.08                                   
REMARK 500    ALA A1360       77.49     68.49                                   
REMARK 500    LYS A1402      -11.75     74.38                                   
REMARK 500    PHE A1421       31.32     78.75                                   
REMARK 500    ARG A1435      -61.62   -102.44                                   
REMARK 500    ASN A1446       63.87   -100.90                                   
REMARK 500    SER A1461      -33.40   -132.57                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS      59 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS                                         
REMARK 500                                                                      
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH          
REMARK 500 CIS AND TRANS CONFORMATION.  CIS BONDS, IF ANY, ARE LISTED           
REMARK 500 ON CISPEP RECORDS.  TRANS IS DEFINED AS 180 +/- 30 AND               
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.                                  
REMARK 500                                 MODEL     OMEGA                      
REMARK 500 TRP A  281     PRO A  282                 -145.57                    
REMARK 500 ASP A  334     ALA A  335                  149.42                    
REMARK 500 PRO A 1514     ARG A 1515                  135.66                    
REMARK 500 ARG A 1515     PRO A 1516                  146.64                    
REMARK 500 PRO A 1516     ALA A 1517                 -147.07                    
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: MAIN CHAIN PLANARITY                                       
REMARK 500                                                                      
REMARK 500 THE FOLLOWING RESIDUES HAVE A PSEUDO PLANARITY                       
REMARK 500 TORSION ANGLE, C(I) - CA(I) - N(I+1) - O(I), GREATER                 
REMARK 500 10.0 DEGREES. (M=MODEL NUMBER; RES=RESIDUE NAME;                     
REMARK 500 C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;                            
REMARK 500 I=INSERTION CODE).                                                   
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        ANGLE                                           
REMARK 500    ARG D  10        -12.02                                           
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 620                                                                      
REMARK 620 METAL COORDINATION                                                   
REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE):                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              NA A2110  NA                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 ASP A 384   OD1                                                    
REMARK 620 2 GLU A 942   OE1 116.8                                              
REMARK 620 N                    1                                               
REMARK 800                                                                      
REMARK 800 SITE                                                                 
REMARK 800 SITE_IDENTIFIER: AC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue 9Z9 A 2109                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue NA A 2110                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG A    
REMARK 800  2101 through BMA A 2103 bound to ASN A 340                          
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG A    
REMARK 800  2107 through NAG A 2108 bound to ASN A 1368                         
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for Poly-Saccharide residues NAG A    
REMARK 800  2104 through NAG A 2105 bound to ASN A 1382                         
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for Mono-Saccharide NAG A 2106        
REMARK 800  bound to ASN A 1393                                                 
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: EMD-9780   RELATED DB: EMDB                              
DBREF  6J8E C   27   148  UNP    O60939   SCN2B_HUMAN     27    148             
DBREF  6J8E A    1  2005  UNP    Q99250   SCN2A_HUMAN      1   2005             
DBREF  6J8E D    1    16  UNP    P0C195   CM3A_CONKI       5     20             
SEQADV 6J8E MET A  -42  UNP  Q99250              EXPRESSION TAG                 
SEQADV 6J8E ALA A  -41  UNP  Q99250              EXPRESSION TAG                 
SEQADV 6J8E SER A  -40  UNP  Q99250              EXPRESSION TAG                 
SEQADV 6J8E TRP A  -39  UNP  Q99250              EXPRESSION TAG                 
SEQADV 6J8E SER A  -38  UNP  Q99250              EXPRESSION TAG                 
SEQADV 6J8E HIS A  -37  UNP  Q99250              EXPRESSION TAG                 
SEQADV 6J8E PRO A  -36  UNP  Q99250              EXPRESSION TAG                 
SEQADV 6J8E GLN A  -35  UNP  Q99250              EXPRESSION TAG                 
SEQADV 6J8E PHE A  -34  UNP  Q99250              EXPRESSION TAG                 
SEQADV 6J8E GLU A  -33  UNP  Q99250              EXPRESSION TAG                 
SEQADV 6J8E LYS A  -32  UNP  Q99250              EXPRESSION TAG                 
SEQADV 6J8E GLY A  -31  UNP  Q99250              EXPRESSION TAG                 
SEQADV 6J8E GLY A  -30  UNP  Q99250              EXPRESSION TAG                 
SEQADV 6J8E GLY A  -29  UNP  Q99250              EXPRESSION TAG                 
SEQADV 6J8E ALA A  -28  UNP  Q99250              EXPRESSION TAG                 
SEQADV 6J8E ARG A  -27  UNP  Q99250              EXPRESSION TAG                 
SEQADV 6J8E GLY A  -26  UNP  Q99250              EXPRESSION TAG                 
SEQADV 6J8E GLY A  -25  UNP  Q99250              EXPRESSION TAG                 
SEQADV 6J8E SER A  -24  UNP  Q99250              EXPRESSION TAG                 
SEQADV 6J8E GLY A  -23  UNP  Q99250              EXPRESSION TAG                 
SEQADV 6J8E GLY A  -22  UNP  Q99250              EXPRESSION TAG                 
SEQADV 6J8E GLY A  -21  UNP  Q99250              EXPRESSION TAG                 
SEQADV 6J8E SER A  -20  UNP  Q99250              EXPRESSION TAG                 
SEQADV 6J8E TRP A  -19  UNP  Q99250              EXPRESSION TAG                 
SEQADV 6J8E SER A  -18  UNP  Q99250              EXPRESSION TAG                 
SEQADV 6J8E HIS A  -17  UNP  Q99250              EXPRESSION TAG                 
SEQADV 6J8E PRO A  -16  UNP  Q99250              EXPRESSION TAG                 
SEQADV 6J8E GLN A  -15  UNP  Q99250              EXPRESSION TAG                 
SEQADV 6J8E PHE A  -14  UNP  Q99250              EXPRESSION TAG                 
SEQADV 6J8E GLU A  -13  UNP  Q99250              EXPRESSION TAG                 
SEQADV 6J8E LYS A  -12  UNP  Q99250              EXPRESSION TAG                 
SEQADV 6J8E GLY A  -11  UNP  Q99250              EXPRESSION TAG                 
SEQADV 6J8E PHE A  -10  UNP  Q99250              EXPRESSION TAG                 
SEQADV 6J8E ASP A   -9  UNP  Q99250              EXPRESSION TAG                 
SEQADV 6J8E TYR A   -8  UNP  Q99250              EXPRESSION TAG                 
SEQADV 6J8E LYS A   -7  UNP  Q99250              EXPRESSION TAG                 
SEQADV 6J8E ASP A   -6  UNP  Q99250              EXPRESSION TAG                 
SEQADV 6J8E ASP A   -5  UNP  Q99250              EXPRESSION TAG                 
SEQADV 6J8E ASP A   -4  UNP  Q99250              EXPRESSION TAG                 
SEQADV 6J8E ASP A   -3  UNP  Q99250              EXPRESSION TAG                 
SEQADV 6J8E LYS A   -2  UNP  Q99250              EXPRESSION TAG                 
SEQADV 6J8E GLY A   -1  UNP  Q99250              EXPRESSION TAG                 
SEQADV 6J8E THR A    0  UNP  Q99250              EXPRESSION TAG                 
SEQRES   1 C  122  GLY ARG SER MET GLU VAL THR VAL PRO ALA THR LEU ASN          
SEQRES   2 C  122  VAL LEU ASN GLY SER ASP ALA ARG LEU PRO CYS THR PHE          
SEQRES   3 C  122  ASN SER CYS TYR THR VAL ASN HIS LYS GLN PHE SER LEU          
SEQRES   4 C  122  ASN TRP THR TYR GLN GLU CYS ASN ASN CYS SER GLU GLU          
SEQRES   5 C  122  MET PHE LEU GLN PHE ARG MET LYS ILE ILE ASN LEU LYS          
SEQRES   6 C  122  LEU GLU ARG PHE GLN ASP ARG VAL GLU PHE SER GLY ASN          
SEQRES   7 C  122  PRO SER LYS TYR ASP VAL SER VAL MET LEU ARG ASN VAL          
SEQRES   8 C  122  GLN PRO GLU ASP GLU GLY ILE TYR ASN CYS TYR ILE MET          
SEQRES   9 C  122  ASN PRO PRO ASP ARG HIS ARG GLY HIS GLY LYS ILE HIS          
SEQRES  10 C  122  LEU GLN VAL LEU MET                                          
SEQRES   1 A 2048  MET ALA SER TRP SER HIS PRO GLN PHE GLU LYS GLY GLY          
SEQRES   2 A 2048  GLY ALA ARG GLY GLY SER GLY GLY GLY SER TRP SER HIS          
SEQRES   3 A 2048  PRO GLN PHE GLU LYS GLY PHE ASP TYR LYS ASP ASP ASP          
SEQRES   4 A 2048  ASP LYS GLY THR MET ALA GLN SER VAL LEU VAL PRO PRO          
SEQRES   5 A 2048  GLY PRO ASP SER PHE ARG PHE PHE THR ARG GLU SER LEU          
SEQRES   6 A 2048  ALA ALA ILE GLU GLN ARG ILE ALA GLU GLU LYS ALA LYS          
SEQRES   7 A 2048  ARG PRO LYS GLN GLU ARG LYS ASP GLU ASP ASP GLU ASN          
SEQRES   8 A 2048  GLY PRO LYS PRO ASN SER ASP LEU GLU ALA GLY LYS SER          
SEQRES   9 A 2048  LEU PRO PHE ILE TYR GLY ASP ILE PRO PRO GLU MET VAL          
SEQRES  10 A 2048  SER VAL PRO LEU GLU ASP LEU ASP PRO TYR TYR ILE ASN          
SEQRES  11 A 2048  LYS LYS THR PHE ILE VAL LEU ASN LYS GLY LYS ALA ILE          
SEQRES  12 A 2048  SER ARG PHE SER ALA THR PRO ALA LEU TYR ILE LEU THR          
SEQRES  13 A 2048  PRO PHE ASN PRO ILE ARG LYS LEU ALA ILE LYS ILE LEU          
SEQRES  14 A 2048  VAL HIS SER LEU PHE ASN MET LEU ILE MET CYS THR ILE          
SEQRES  15 A 2048  LEU THR ASN CYS VAL PHE MET THR MET SER ASN PRO PRO          
SEQRES  16 A 2048  ASP TRP THR LYS ASN VAL GLU TYR THR PHE THR GLY ILE          
SEQRES  17 A 2048  TYR THR PHE GLU SER LEU ILE LYS ILE LEU ALA ARG GLY          
SEQRES  18 A 2048  PHE CYS LEU GLU ASP PHE THR PHE LEU ARG ASP PRO TRP          
SEQRES  19 A 2048  ASN TRP LEU ASP PHE THR VAL ILE THR PHE ALA TYR VAL          
SEQRES  20 A 2048  THR GLU PHE VAL ASP LEU GLY ASN VAL SER ALA LEU ARG          
SEQRES  21 A 2048  THR PHE ARG VAL LEU ARG ALA LEU LYS THR ILE SER VAL          
SEQRES  22 A 2048  ILE PRO GLY LEU LYS THR ILE VAL GLY ALA LEU ILE GLN          
SEQRES  23 A 2048  SER VAL LYS LYS LEU SER ASP VAL MET ILE LEU THR VAL          
SEQRES  24 A 2048  PHE CYS LEU SER VAL PHE ALA LEU ILE GLY LEU GLN LEU          
SEQRES  25 A 2048  PHE MET GLY ASN LEU ARG ASN LYS CYS LEU GLN TRP PRO          
SEQRES  26 A 2048  PRO ASP ASN SER SER PHE GLU ILE ASN ILE THR SER PHE          
SEQRES  27 A 2048  PHE ASN ASN SER LEU ASP GLY ASN GLY THR THR PHE ASN          
SEQRES  28 A 2048  ARG THR VAL SER ILE PHE ASN TRP ASP GLU TYR ILE GLU          
SEQRES  29 A 2048  ASP LYS SER HIS PHE TYR PHE LEU GLU GLY GLN ASN ASP          
SEQRES  30 A 2048  ALA LEU LEU CYS GLY ASN SER SER ASP ALA GLY GLN CYS          
SEQRES  31 A 2048  PRO GLU GLY TYR ILE CYS VAL LYS ALA GLY ARG ASN PRO          
SEQRES  32 A 2048  ASN TYR GLY TYR THR SER PHE ASP THR PHE SER TRP ALA          
SEQRES  33 A 2048  PHE LEU SER LEU PHE ARG LEU MET THR GLN ASP PHE TRP          
SEQRES  34 A 2048  GLU ASN LEU TYR GLN LEU THR LEU ARG ALA ALA GLY LYS          
SEQRES  35 A 2048  THR TYR MET ILE PHE PHE VAL LEU VAL ILE PHE LEU GLY          
SEQRES  36 A 2048  SER PHE TYR LEU ILE ASN LEU ILE LEU ALA VAL VAL ALA          
SEQRES  37 A 2048  MET ALA TYR GLU GLU GLN ASN GLN ALA THR LEU GLU GLU          
SEQRES  38 A 2048  ALA GLU GLN LYS GLU ALA GLU PHE GLN GLN MET LEU GLU          
SEQRES  39 A 2048  GLN LEU LYS LYS GLN GLN GLU GLU ALA GLN ALA ALA ALA          
SEQRES  40 A 2048  ALA ALA ALA SER ALA GLU SER ARG ASP PHE SER GLY ALA          
SEQRES  41 A 2048  GLY GLY ILE GLY VAL PHE SER GLU SER SER SER VAL ALA          
SEQRES  42 A 2048  SER LYS LEU SER SER LYS SER GLU LYS GLU LEU LYS ASN          
SEQRES  43 A 2048  ARG ARG LYS LYS LYS LYS GLN LYS GLU GLN SER GLY GLU          
SEQRES  44 A 2048  GLU GLU LYS ASN ASP ARG VAL ARG LYS SER GLU SER GLU          
SEQRES  45 A 2048  ASP SER ILE ARG ARG LYS GLY PHE ARG PHE SER LEU GLU          
SEQRES  46 A 2048  GLY SER ARG LEU THR TYR GLU LYS ARG PHE SER SER PRO          
SEQRES  47 A 2048  HIS GLN SER LEU LEU SER ILE ARG GLY SER LEU PHE SER          
SEQRES  48 A 2048  PRO ARG ARG ASN SER ARG ALA SER LEU PHE SER PHE ARG          
SEQRES  49 A 2048  GLY ARG ALA LYS ASP ILE GLY SER GLU ASN ASP PHE ALA          
SEQRES  50 A 2048  ASP ASP GLU HIS SER THR PHE GLU ASP ASN ASP SER ARG          
SEQRES  51 A 2048  ARG ASP SER LEU PHE VAL PRO HIS ARG HIS GLY GLU ARG          
SEQRES  52 A 2048  ARG HIS SER ASN VAL SER GLN ALA SER ARG ALA SER ARG          
SEQRES  53 A 2048  VAL LEU PRO ILE LEU PRO MET ASN GLY LYS MET HIS SER          
SEQRES  54 A 2048  ALA VAL ASP CYS ASN GLY VAL VAL SER LEU VAL GLY GLY          
SEQRES  55 A 2048  PRO SER THR LEU THR SER ALA GLY GLN LEU LEU PRO GLU          
SEQRES  56 A 2048  GLY THR THR THR GLU THR GLU ILE ARG LYS ARG ARG SER          
SEQRES  57 A 2048  SER SER TYR HIS VAL SER MET ASP LEU LEU GLU ASP PRO          
SEQRES  58 A 2048  THR SER ARG GLN ARG ALA MET SER ILE ALA SER ILE LEU          
SEQRES  59 A 2048  THR ASN THR MET GLU GLU LEU GLU GLU SER ARG GLN LYS          
SEQRES  60 A 2048  CYS PRO PRO CYS TRP TYR LYS PHE ALA ASN MET CYS LEU          
SEQRES  61 A 2048  ILE TRP ASP CYS CYS LYS PRO TRP LEU LYS VAL LYS HIS          
SEQRES  62 A 2048  LEU VAL ASN LEU VAL VAL MET ASP PRO PHE VAL ASP LEU          
SEQRES  63 A 2048  ALA ILE THR ILE CYS ILE VAL LEU ASN THR LEU PHE MET          
SEQRES  64 A 2048  ALA MET GLU HIS TYR PRO MET THR GLU GLN PHE SER SER          
SEQRES  65 A 2048  VAL LEU SER VAL GLY ASN LEU VAL PHE THR GLY ILE PHE          
SEQRES  66 A 2048  THR ALA GLU MET PHE LEU LYS ILE ILE ALA MET ASP PRO          
SEQRES  67 A 2048  TYR TYR TYR PHE GLN GLU GLY TRP ASN ILE PHE ASP GLY          
SEQRES  68 A 2048  PHE ILE VAL SER LEU SER LEU MET GLU LEU GLY LEU ALA          
SEQRES  69 A 2048  ASN VAL GLU GLY LEU SER VAL LEU ARG SER PHE ARG LEU          
SEQRES  70 A 2048  LEU ARG VAL PHE LYS LEU ALA LYS SER TRP PRO THR LEU          
SEQRES  71 A 2048  ASN MET LEU ILE LYS ILE ILE GLY ASN SER VAL GLY ALA          
SEQRES  72 A 2048  LEU GLY ASN LEU THR LEU VAL LEU ALA ILE ILE VAL PHE          
SEQRES  73 A 2048  ILE PHE ALA VAL VAL GLY MET GLN LEU PHE GLY LYS SER          
SEQRES  74 A 2048  TYR LYS GLU CYS VAL CYS LYS ILE SER ASN ASP CYS GLU          
SEQRES  75 A 2048  LEU PRO ARG TRP HIS MET HIS ASP PHE PHE HIS SER PHE          
SEQRES  76 A 2048  LEU ILE VAL PHE ARG VAL LEU CYS GLY GLU TRP ILE GLU          
SEQRES  77 A 2048  THR MET TRP ASP CYS MET GLU VAL ALA GLY GLN THR MET          
SEQRES  78 A 2048  CYS LEU THR VAL PHE MET MET VAL MET VAL ILE GLY ASN          
SEQRES  79 A 2048  LEU VAL VAL LEU ASN LEU PHE LEU ALA LEU LEU LEU SER          
SEQRES  80 A 2048  SER PHE SER SER ASP ASN LEU ALA ALA THR ASP ASP ASP          
SEQRES  81 A 2048  ASN GLU MET ASN ASN LEU GLN ILE ALA VAL GLY ARG MET          
SEQRES  82 A 2048  GLN LYS GLY ILE ASP PHE VAL LYS ARG LYS ILE ARG GLU          
SEQRES  83 A 2048  PHE ILE GLN LYS ALA PHE VAL ARG LYS GLN LYS ALA LEU          
SEQRES  84 A 2048  ASP GLU ILE LYS PRO LEU GLU ASP LEU ASN ASN LYS LYS          
SEQRES  85 A 2048  ASP SER CYS ILE SER ASN HIS THR THR ILE GLU ILE GLY          
SEQRES  86 A 2048  LYS ASP LEU ASN TYR LEU LYS ASP GLY ASN GLY THR THR          
SEQRES  87 A 2048  SER GLY ILE GLY SER SER VAL GLU LYS TYR VAL VAL ASP          
SEQRES  88 A 2048  GLU SER ASP TYR MET SER PHE ILE ASN ASN PRO SER LEU          
SEQRES  89 A 2048  THR VAL THR VAL PRO ILE ALA VAL GLY GLU SER ASP PHE          
SEQRES  90 A 2048  GLU ASN LEU ASN THR GLU GLU PHE SER SER GLU SER ASP          
SEQRES  91 A 2048  MET GLU GLU SER LYS GLU LYS LEU ASN ALA THR SER SER          
SEQRES  92 A 2048  SER GLU GLY SER THR VAL ASP ILE GLY ALA PRO ALA GLU          
SEQRES  93 A 2048  GLY GLU GLN PRO GLU VAL GLU PRO GLU GLU SER LEU GLU          
SEQRES  94 A 2048  PRO GLU ALA CYS PHE THR GLU ASP CYS VAL ARG LYS PHE          
SEQRES  95 A 2048  LYS CYS CYS GLN ILE SER ILE GLU GLU GLY LYS GLY LYS          
SEQRES  96 A 2048  LEU TRP TRP ASN LEU ARG LYS THR CYS TYR LYS ILE VAL          
SEQRES  97 A 2048  GLU HIS ASN TRP PHE GLU THR PHE ILE VAL PHE MET ILE          
SEQRES  98 A 2048  LEU LEU SER SER GLY ALA LEU ALA PHE GLU ASP ILE TYR          
SEQRES  99 A 2048  ILE GLU GLN ARG LYS THR ILE LYS THR MET LEU GLU TYR          
SEQRES 100 A 2048  ALA ASP LYS VAL PHE THR TYR ILE PHE ILE LEU GLU MET          
SEQRES 101 A 2048  LEU LEU LYS TRP VAL ALA TYR GLY PHE GLN VAL TYR PHE          
SEQRES 102 A 2048  THR ASN ALA TRP CYS TRP LEU ASP PHE LEU ILE VAL ASP          
SEQRES 103 A 2048  VAL SER LEU VAL SER LEU THR ALA ASN ALA LEU GLY TYR          
SEQRES 104 A 2048  SER GLU LEU GLY ALA ILE LYS SER LEU ARG THR LEU ARG          
SEQRES 105 A 2048  ALA LEU ARG PRO LEU ARG ALA LEU SER ARG PHE GLU GLY          
SEQRES 106 A 2048  MET ARG VAL VAL VAL ASN ALA LEU LEU GLY ALA ILE PRO          
SEQRES 107 A 2048  SER ILE MET ASN VAL LEU LEU VAL CYS LEU ILE PHE TRP          
SEQRES 108 A 2048  LEU ILE PHE SER ILE MET GLY VAL ASN LEU PHE ALA GLY          
SEQRES 109 A 2048  LYS PHE TYR HIS CYS ILE ASN TYR THR THR GLY GLU MET          
SEQRES 110 A 2048  PHE ASP VAL SER VAL VAL ASN ASN TYR SER GLU CYS LYS          
SEQRES 111 A 2048  ALA LEU ILE GLU SER ASN GLN THR ALA ARG TRP LYS ASN          
SEQRES 112 A 2048  VAL LYS VAL ASN PHE ASP ASN VAL GLY LEU GLY TYR LEU          
SEQRES 113 A 2048  SER LEU LEU GLN VAL ALA THR PHE LYS GLY TRP MET ASP          
SEQRES 114 A 2048  ILE MET TYR ALA ALA VAL ASP SER ARG ASN VAL GLU LEU          
SEQRES 115 A 2048  GLN PRO LYS TYR GLU ASP ASN LEU TYR MET TYR LEU TYR          
SEQRES 116 A 2048  PHE VAL ILE PHE ILE ILE PHE GLY SER PHE PHE THR LEU          
SEQRES 117 A 2048  ASN LEU PHE ILE GLY VAL ILE ILE ASP ASN PHE ASN GLN          
SEQRES 118 A 2048  GLN LYS LYS LYS PHE GLY GLY GLN ASP ILE PHE MET THR          
SEQRES 119 A 2048  GLU GLU GLN LYS LYS TYR TYR ASN ALA MET LYS LYS LEU          
SEQRES 120 A 2048  GLY SER LYS LYS PRO GLN LYS PRO ILE PRO ARG PRO ALA          
SEQRES 121 A 2048  ASN LYS PHE GLN GLY MET VAL PHE ASP PHE VAL THR LYS          
SEQRES 122 A 2048  GLN VAL PHE ASP ILE SER ILE MET ILE LEU ILE CYS LEU          
SEQRES 123 A 2048  ASN MET VAL THR MET MET VAL GLU THR ASP ASP GLN SER          
SEQRES 124 A 2048  GLN GLU MET THR ASN ILE LEU TYR TRP ILE ASN LEU VAL          
SEQRES 125 A 2048  PHE ILE VAL LEU PHE THR GLY GLU CYS VAL LEU LYS LEU          
SEQRES 126 A 2048  ILE SER LEU ARG TYR TYR TYR PHE THR ILE GLY TRP ASN          
SEQRES 127 A 2048  ILE PHE ASP PHE VAL VAL VAL ILE LEU SER ILE VAL GLY          
SEQRES 128 A 2048  MET PHE LEU ALA GLU LEU ILE GLU LYS TYR PHE VAL SER          
SEQRES 129 A 2048  PRO THR LEU PHE ARG VAL ILE ARG LEU ALA ARG ILE GLY          
SEQRES 130 A 2048  ARG ILE LEU ARG LEU ILE LYS GLY ALA LYS GLY ILE ARG          
SEQRES 131 A 2048  THR LEU LEU PHE ALA LEU MET MET SER LEU PRO ALA LEU          
SEQRES 132 A 2048  PHE ASN ILE GLY LEU LEU LEU PHE LEU VAL MET PHE ILE          
SEQRES 133 A 2048  TYR ALA ILE PHE GLY MET SER ASN PHE ALA TYR VAL LYS          
SEQRES 134 A 2048  ARG GLU VAL GLY ILE ASP ASP MET PHE ASN PHE GLU THR          
SEQRES 135 A 2048  PHE GLY ASN SER MET ILE CYS LEU PHE GLN ILE THR THR          
SEQRES 136 A 2048  SER ALA GLY TRP ASP GLY LEU LEU ALA PRO ILE LEU ASN          
SEQRES 137 A 2048  SER GLY PRO PRO ASP CYS ASP PRO ASP LYS ASP HIS PRO          
SEQRES 138 A 2048  GLY SER SER VAL LYS GLY ASP CYS GLY ASN PRO SER VAL          
SEQRES 139 A 2048  GLY ILE PHE PHE PHE VAL SER TYR ILE ILE ILE SER PHE          
SEQRES 140 A 2048  LEU VAL VAL VAL ASN MET TYR ILE ALA VAL ILE LEU GLU          
SEQRES 141 A 2048  ASN PHE SER VAL ALA THR GLU GLU SER ALA GLU PRO LEU          
SEQRES 142 A 2048  SER GLU ASP ASP PHE GLU MET PHE TYR GLU VAL TRP GLU          
SEQRES 143 A 2048  LYS PHE ASP PRO ASP ALA THR GLN PHE ILE GLU PHE ALA          
SEQRES 144 A 2048  LYS LEU SER ASP PHE ALA ASP ALA LEU ASP PRO PRO LEU          
SEQRES 145 A 2048  LEU ILE ALA LYS PRO ASN LYS VAL GLN LEU ILE ALA MET          
SEQRES 146 A 2048  ASP LEU PRO MET VAL SER GLY ASP ARG ILE HIS CYS LEU          
SEQRES 147 A 2048  ASP ILE LEU PHE ALA PHE THR LYS ARG VAL LEU GLY GLU          
SEQRES 148 A 2048  SER GLY GLU MET ASP ALA LEU ARG ILE GLN MET GLU GLU          
SEQRES 149 A 2048  ARG PHE MET ALA SER ASN PRO SER LYS VAL SER TYR GLU          
SEQRES 150 A 2048  PRO ILE THR THR THR LEU LYS ARG LYS GLN GLU GLU VAL          
SEQRES 151 A 2048  SER ALA ILE ILE ILE GLN ARG ALA TYR ARG ARG TYR LEU          
SEQRES 152 A 2048  LEU LYS GLN LYS VAL LYS LYS VAL SER SER ILE TYR LYS          
SEQRES 153 A 2048  LYS ASP LYS GLY LYS GLU CYS ASP GLY THR PRO ILE LYS          
SEQRES 154 A 2048  GLU ASP THR LEU ILE ASP LYS LEU ASN GLU ASN SER THR          
SEQRES 155 A 2048  PRO GLU LYS THR ASP MET THR PRO SER THR THR SER PRO          
SEQRES 156 A 2048  PRO SER TYR ASP SER VAL THR LYS PRO GLU LYS GLU LYS          
SEQRES 157 A 2048  PHE GLU LYS ASP LYS SER GLU LYS GLU ASP LYS GLY LYS          
SEQRES 158 A 2048  ASP ILE ARG GLU SER LYS LYS                                  
SEQRES   1 D   16  CYS CYS ASN CYS SER SER LYS TRP CYS ARG ASP HIS SER          
SEQRES   2 D   16  ARG CYS CYS                                                  
HET    NAG  A2101      14                                                       
HET    NAG  A2102      14                                                       
HET    BMA  A2103      11                                                       
HET    NAG  A2104      14                                                       
HET    NAG  A2105      14                                                       
HET    NAG  A2106      14                                                       
HET    NAG  A2107      14                                                       
HET    NAG  A2108      14                                                       
HET    9Z9  A2109      39                                                       
HET     NA  A2110       1                                                       
HETNAM     NAG N-ACETYL-D-GLUCOSAMINE                                           
HETNAM     BMA BETA-D-MANNOSE                                                   
HETNAM     9Z9 (3BETA,14BETA,17BETA,25R)-3-[4-METHOXY-3-                        
HETNAM   2 9Z9  (METHOXYMETHYL)BUTOXY]SPIROST-5-EN                              
HETNAM      NA SODIUM ION                                                       
FORMUL   4  NAG    7(C8 H15 N O6)                                               
FORMUL   4  BMA    C6 H12 O6                                                    
FORMUL   8  9Z9    C34 H56 O5                                                   
FORMUL   9   NA    NA 1+                                                        
HELIX    1 AA1 ASN C  104  TYR C  108  5                                   5    
HELIX    2 AA2 GLN C  118  GLU C  122  5                                   5    
HELIX    3 AA3 ILE A  118  ALA A  122  1                                   5    
HELIX    4 AA4 ILE A  123  HIS A  128  1                                   6    
HELIX    5 AA5 HIS A  128  MET A  146  1                                  19    
HELIX    6 AA6 THR A  155  LEU A  175  1                                  21    
HELIX    7 AA7 ASP A  189  TYR A  203  1                                  15    
HELIX    8 AA8 VAL A  204  PHE A  207  5                                   4    
HELIX    9 AA9 ARG A  217  LEU A  225  5                                   9    
HELIX   10 AB1 LYS A  226  ILE A  231  1                                   6    
HELIX   11 AB2 GLY A  233  LYS A  246  1                                  14    
HELIX   12 AB3 LYS A  247  SER A  249  5                                   3    
HELIX   13 AB4 ASP A  250  PHE A  270  1                                  21    
HELIX   14 AB5 GLY A  272  LEU A  274  5                                   3    
HELIX   15 AB6 THR A  369  THR A  382  1                                  14    
HELIX   16 AB7 PHE A  385  ALA A  397  1                                  13    
HELIX   17 AB8 GLY A  398  THR A  400  5                                   3    
HELIX   18 AB9 TYR A  401  GLY A  412  1                                  12    
HELIX   19 AC1 PHE A  414  GLN A  441  1                                  28    
HELIX   20 AC2 CYS A  741  LEU A  754  1                                  14    
HELIX   21 AC3 ASP A  762  MET A  778  1                                  17    
HELIX   22 AC4 PHE A  787  LEU A  808  1                                  22    
HELIX   23 AC5 GLY A  822  ALA A  841  1                                  20    
HELIX   24 AC6 LEU A  846  SER A  863  5                                  18    
HELIX   25 AC7 TRP A  864  GLY A  879  1                                  16    
HELIX   26 AC8 LEU A  881  PHE A  903  1                                  23    
HELIX   27 AC9 PHE A  903  CYS A  910  1                                   8    
HELIX   28 AD1 ASP A  927  LEU A  939  1                                  13    
HELIX   29 AD2 TRP A  943  GLY A  955  1                                  13    
HELIX   30 AD3 GLY A  955  PHE A  986  1                                  32    
HELIX   31 AD4 TRP A 1194  GLU A 1206  1                                  13    
HELIX   32 AD5 HIS A 1207  ALA A 1224  1                                  18    
HELIX   33 AD6 LEU A 1225  GLU A 1228  5                                   4    
HELIX   34 AD7 TYR A 1231  LYS A 1236  1                                   6    
HELIX   35 AD8 ILE A 1238  GLY A 1265  1                                  28    
HELIX   36 AD9 GLY A 1265  PHE A 1270  1                                   6    
HELIX   37 AE1 ASN A 1272  GLY A 1295  1                                  24    
HELIX   38 AE2 ALA A 1301  ARG A 1306  1                                   6    
HELIX   39 AE3 THR A 1307  LEU A 1317  5                                  11    
HELIX   40 AE4 PHE A 1320  LEU A 1331  1                                  12    
HELIX   41 AE5 ALA A 1333  PHE A 1359  1                                  27    
HELIX   42 AE6 ASN A 1382  GLU A 1391  1                                  10    
HELIX   43 AE7 VAL A 1408  PHE A 1421  1                                  14    
HELIX   44 AE8 GLY A 1423  ASP A 1433  1                                  11    
HELIX   45 AE9 ASN A 1446  TYR A 1448  5                                   3    
HELIX   46 AF1 MET A 1449  GLY A 1460  1                                  12    
HELIX   47 AF2 PHE A 1462  PHE A 1483  1                                  22    
HELIX   48 AF3 THR A 1491  TYR A 1497  1                                   7    
HELIX   49 AF4 ALA A 1500  SER A 1506  1                                   7    
HELIX   50 AF5 LYS A 1519  THR A 1529  1                                  11    
HELIX   51 AF6 LYS A 1530  VAL A 1550  1                                  21    
HELIX   52 AF7 SER A 1556  LEU A 1585  1                                  30    
HELIX   53 AF8 ILE A 1592  GLU A 1616  1                                  25    
HELIX   54 AF9 SER A 1621  ARG A 1629  1                                   9    
HELIX   55 AG1 LEU A 1630  GLY A 1634  5                                   5    
HELIX   56 AG2 ARG A 1635  GLY A 1642  5                                   8    
HELIX   57 AG3 GLY A 1645  MET A 1655  1                                  11    
HELIX   58 AG4 SER A 1656  PHE A 1682  1                                  27    
HELIX   59 AG5 THR A 1699  THR A 1711  1                                  13    
HELIX   60 AG6 GLY A 1715  ALA A 1721  1                                   7    
HELIX   61 AG7 ASN A 1748  GLU A 1785  1                                  38    
HELIX   62 AG8 SER D    6  SER D   13  1                                   8    
SHEET    1 AA1 2 VAL C  32  THR C  33  0                                        
SHEET    2 AA1 2 THR C  51  PHE C  52 -1  O  THR C  51   N  THR C  33           
SHEET    1 AA2 6 THR C  37  LEU C  41  0                                        
SHEET    2 AA2 6 GLY C 138  LEU C 147  1  O  GLN C 145   N  LEU C  38           
SHEET    3 AA2 6 GLY C 123  MET C 130 -1  N  ILE C 129   O  GLY C 138           
SHEET    4 AA2 6 SER C  64  GLN C  70 -1  N  ASN C  66   O  TYR C 128           
SHEET    5 AA2 6 GLU C  77  ARG C  84 -1  O  GLU C  78   N  TYR C  69           
SHEET    6 AA2 6 ILE C  87  ASN C  89 -1  O  ILE C  88   N  GLN C  82           
SHEET    1 AA3 3 ALA C  46  LEU C  48  0                                        
SHEET    2 AA3 3 VAL C 112  LEU C 114 -1  O  VAL C 112   N  LEU C  48           
SHEET    3 AA3 3 VAL C  99  PHE C 101 -1  N  GLU C 100   O  MET C 113           
SHEET    1 AA4 2 ASN A 276  GLN A 280  0                                        
SHEET    2 AA4 2 TYR A 351  LYS A 355 -1  O  ILE A 352   N  LEU A 279           
SHEET    1 AA5 2 HIS A1365  ILE A1367  0                                        
SHEET    2 AA5 2 ARG A1397  LYS A1399 -1  O  LYS A1399   N  HIS A1365           
SSBOND   1 CYS C   50    CYS C  127                          1555   1555  1.84  
SSBOND   2 CYS C   55    CYS A  910                          1555   1555  2.09  
SSBOND   3 CYS C   72    CYS C   75                          1555   1555  2.03  
SSBOND   4 CYS A  278    CYS A  338                          1555   1555  2.03  
SSBOND   5 CYS A  912    CYS A  918                          1555   1555  2.04  
SSBOND   6 CYS A  950    CYS A  959                          1555   1555  2.05  
SSBOND   7 CYS A 1366    CYS A 1386                          1555   1555  2.01  
SSBOND   8 CYS A 1731    CYS A 1746                          1555   1555  2.03  
SSBOND   9 CYS D    1    CYS D   15                          1555   1555  2.03  
SSBOND  10 CYS D    2    CYS D    9                          1555   1555  2.03  
SSBOND  11 CYS D    4    CYS D   16                          1555   1555  2.03  
LINK         ND2 ASN A 340                 C1  NAG A2101     1555   1555  1.43  
LINK         OD1 ASP A 384                NA    NA A2110     1555   1555  3.11  
LINK         OE1 GLU A 942                NA    NA A2110     1555   1555  3.10  
LINK         ND2 ASN A1368                 C1  NAG A2107     1555   1555  1.43  
LINK         ND2 ASN A1382                 C1  NAG A2104     1555   1555  1.43  
LINK         ND2 ASN A1393                 C1  NAG A2106     1555   1555  1.43  
LINK         O4  NAG A2101                 C1  NAG A2102     1555   1555  1.42  
LINK         O4  NAG A2102                 C1  BMA A2103     1555   1555  1.44  
LINK         O4  NAG A2104                 C1  NAG A2105     1555   1555  1.46  
LINK         O4  NAG A2107                 C1  NAG A2108     1555   1555  1.44  
CISPEP   1 PRO C  132    PRO C  133          0         5.46                     
CISPEP   2 TYR A  781    PRO A  782          0        -7.31                     
CISPEP   3 PRO A  815    TYR A  816          0        -1.24                     
CISPEP   4 GLU A  844    GLY A  845          0        -0.73                     
CISPEP   5 GLY A 1484    GLY A 1485          0       -14.42                     
CISPEP   6 PRO A 1728    PRO A 1729          0         9.69                     
CISPEP   7 PRO A 1738    GLY A 1739          0         1.50                     
SITE     1 AC1 11 LEU A 421  ALA A 425  PHE A 978  LEU A 979                    
SITE     2 AC1 11 LEU A 982  ILE A1473  PHE A1764  TYR A1771                    
SITE     3 AC1 11 ILE A1775  LEU A1776  PHE A1779                               
SITE     1 AC2  3 ASP A 384  GLU A 942  GLU A 945                               
SITE     1 AC3  4 ASN A 276  TRP A 316  ASN A 340  CYS A 353                    
SITE     1 AC4  4 ASN A1368  THR A1370  PHE A1375  GLN A1394                    
SITE     1 AC5  3 ASN A1381  ASN A1382  GLU A1385                               
SITE     1 AC6  3 GLU A1391  SER A1392  ASN A1393                               
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1           1          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      1.000000  0.000000  0.000000        0.00000                         
SCALE2      0.000000  1.000000  0.000000        0.00000                         
SCALE3      0.000000  0.000000  1.000000        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
DBGET integrated database retrieval system