HEADER TRANSLATION 07-MAR-19 6JLZ
TITLE P-EIF2A - EIF2B COMPLEX
COMPND MOL_ID: 1;
COMPND 2 MOLECULE: TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA;
COMPND 3 CHAIN: A, B;
COMPND 4 SYNONYM: EIF2BA,EIF-2B GDP-GTP EXCHANGE FACTOR SUBUNIT ALPHA;
COMPND 5 ENGINEERED: YES;
COMPND 6 MOL_ID: 2;
COMPND 7 MOLECULE: PROBABLE TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA;
COMPND 8 CHAIN: C, D;
COMPND 9 SYNONYM: EIF2BB,EIF-2B GDP-GTP EXCHANGE FACTOR SUBUNIT BETA;
COMPND 10 ENGINEERED: YES;
COMPND 11 MOL_ID: 3;
COMPND 12 MOLECULE: PROBABLE TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT
COMPND 13 GAMMA;
COMPND 14 CHAIN: E, F;
COMPND 15 SYNONYM: EIF2BG,EIF-2B GDP-GTP EXCHANGE FACTOR SUBUNIT GAMMA;
COMPND 16 ENGINEERED: YES;
COMPND 17 MOL_ID: 4;
COMPND 18 MOLECULE: PROBABLE TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT
COMPND 19 DELTA;
COMPND 20 CHAIN: G, H;
COMPND 21 SYNONYM: EIF2BD,EIF-2B GDP-GTP EXCHANGE FACTOR SUBUNIT DELTA;
COMPND 22 ENGINEERED: YES;
COMPND 23 MOL_ID: 5;
COMPND 24 MOLECULE: PROBABLE TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT
COMPND 25 EPSILON;
COMPND 26 CHAIN: I, J;
COMPND 27 SYNONYM: EIF2BE,EIF-2B GDP-GTP EXCHANGE FACTOR SUBUNIT EPSILON;
COMPND 28 ENGINEERED: YES;
COMPND 29 MOL_ID: 6;
COMPND 30 MOLECULE: EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT ALPHA;
COMPND 31 CHAIN: L, M;
COMPND 32 SYNONYM: EIF2A,EIF-2-ALPHA;
COMPND 33 ENGINEERED: YES
SOURCE MOL_ID: 1;
SOURCE 2 ORGANISM_SCIENTIFIC: SCHIZOSACCHAROMYCES POMBE (STRAIN 972 / ATCC
SOURCE 3 24843);
SOURCE 4 ORGANISM_COMMON: FISSION YEAST;
SOURCE 5 ORGANISM_TAXID: 284812;
SOURCE 6 STRAIN: 972 / ATCC 24843;
SOURCE 7 GENE: TIF221, SPCC11E10.07C;
SOURCE 8 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE 9 EXPRESSION_SYSTEM_TAXID: 562;
SOURCE 10 MOL_ID: 2;
SOURCE 11 ORGANISM_SCIENTIFIC: SCHIZOSACCHAROMYCES POMBE (STRAIN 972 / ATCC
SOURCE 12 24843);
SOURCE 13 ORGANISM_COMMON: FISSION YEAST;
SOURCE 14 ORGANISM_TAXID: 284812;
SOURCE 15 STRAIN: 972 / ATCC 24843;
SOURCE 16 GENE: TIF222, SPAC343.14C;
SOURCE 17 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE 18 EXPRESSION_SYSTEM_TAXID: 562;
SOURCE 19 MOL_ID: 3;
SOURCE 20 ORGANISM_SCIENTIFIC: SCHIZOSACCHAROMYCES POMBE (STRAIN 972 / ATCC
SOURCE 21 24843);
SOURCE 22 ORGANISM_COMMON: FISSION YEAST;
SOURCE 23 ORGANISM_TAXID: 284812;
SOURCE 24 STRAIN: 972 / ATCC 24843;
SOURCE 25 GENE: TIF223, SPAC4D7.09;
SOURCE 26 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE 27 EXPRESSION_SYSTEM_TAXID: 562;
SOURCE 28 MOL_ID: 4;
SOURCE 29 ORGANISM_SCIENTIFIC: SCHIZOSACCHAROMYCES POMBE (STRAIN 972 / ATCC
SOURCE 30 24843);
SOURCE 31 ORGANISM_COMMON: FISSION YEAST;
SOURCE 32 ORGANISM_TAXID: 284812;
SOURCE 33 STRAIN: 972 / ATCC 24843;
SOURCE 34 GENE: TIF224, SPAC21E11.06;
SOURCE 35 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE 36 EXPRESSION_SYSTEM_TAXID: 562;
SOURCE 37 MOL_ID: 5;
SOURCE 38 ORGANISM_SCIENTIFIC: SCHIZOSACCHAROMYCES POMBE (STRAIN 972 / ATCC
SOURCE 39 24843);
SOURCE 40 ORGANISM_COMMON: FISSION YEAST;
SOURCE 41 ORGANISM_TAXID: 284812;
SOURCE 42 STRAIN: 972 / ATCC 24843;
SOURCE 43 GENE: TIF225, SPAC8C9.15C;
SOURCE 44 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE 45 EXPRESSION_SYSTEM_TAXID: 562;
SOURCE 46 MOL_ID: 6;
SOURCE 47 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE (STRAIN ATCC 204508 /
SOURCE 48 S288C);
SOURCE 49 ORGANISM_COMMON: BAKER'S YEAST;
SOURCE 50 ORGANISM_TAXID: 559292;
SOURCE 51 STRAIN: ATCC 204508 / S288C;
SOURCE 52 GENE: SUI2, TIF211, YJR007W, J1429;
SOURCE 53 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE 54 EXPRESSION_SYSTEM_TAXID: 562
KEYWDS TRANSLATION INITIATION, TRANSLATION
EXPDTA X-RAY DIFFRACTION
AUTHOR K.KASHIWAGI,T.ITO
REVDAT 2 15-MAY-19 6JLZ 1 JRNL
REVDAT 1 01-MAY-19 6JLZ 0
JRNL AUTH K.KASHIWAGI,T.YOKOYAMA,M.NISHIMOTO,M.TAKAHASHI,A.SAKAMOTO,
JRNL AUTH 2 M.YONEMOCHI,M.SHIROUZU,T.ITO
JRNL TITL STRUCTURAL BASIS FOR EIF2B INHIBITION IN INTEGRATED STRESS
JRNL TITL 2 RESPONSE.
JRNL REF SCIENCE V. 364 495 2019
JRNL REFN ESSN 1095-9203
JRNL PMID 31048492
JRNL DOI 10.1126/SCIENCE.AAW4104
REMARK 2
REMARK 2 RESOLUTION. 3.35 ANGSTROMS.
REMARK 3
REMARK 3 REFINEMENT.
REMARK 3 PROGRAM : PHENIX (1.13_2998: ???)
REMARK 3 AUTHORS : PAUL ADAMS,PAVEL AFONINE,VINCENT CHEN,IAN
REMARK 3 : DAVIS,KRESHNA GOPAL,RALF GROSSE-KUNSTLEVE,
REMARK 3 : LI-WEI HUNG,ROBERT IMMORMINO,TOM IOERGER,
REMARK 3 : AIRLIE MCCOY,ERIK MCKEE,NIGEL MORIARTY,
REMARK 3 : REETAL PAI,RANDY READ,JANE RICHARDSON,
REMARK 3 : DAVID RICHARDSON,TOD ROMO,JIM SACCHETTINI,
REMARK 3 : NICHOLAS SAUTER,JACOB SMITH,LAURENT
REMARK 3 : STORONI,TOM TERWILLIGER,PETER ZWART
REMARK 3
REMARK 3 REFINEMENT TARGET : NULL
REMARK 3
REMARK 3 DATA USED IN REFINEMENT.
REMARK 3 RESOLUTION RANGE HIGH (ANGSTROMS) : 3.35
REMARK 3 RESOLUTION RANGE LOW (ANGSTROMS) : 49.31
REMARK 3 MIN(FOBS/SIGMA_FOBS) : NULL
REMARK 3 COMPLETENESS FOR RANGE (%) : 97.6
REMARK 3 NUMBER OF REFLECTIONS : 140590
REMARK 3
REMARK 3 FIT TO DATA USED IN REFINEMENT.
REMARK 3 R VALUE (WORKING + TEST SET) : 0.221
REMARK 3 R VALUE (WORKING SET) : 0.221
REMARK 3 FREE R VALUE : 0.253
REMARK 3 FREE R VALUE TEST SET SIZE (%) : 1.430
REMARK 3 FREE R VALUE TEST SET COUNT : 3883
REMARK 3
REMARK 3 FIT TO DATA USED IN REFINEMENT (IN BINS).
REMARK 3 BIN RESOLUTION RANGE COMPL. NWORK NFREE RWORK RFREE
REMARK 3 1 49.3186 - 10.1380 0.97 9506 145 0.1821 0.1654
REMARK 3 2 10.1380 - 8.0582 0.98 9600 141 0.1645 0.1660
REMARK 3 3 8.0582 - 7.0429 0.98 9536 139 0.2027 0.2717
REMARK 3 4 7.0429 - 6.4005 0.99 9739 141 0.2352 0.2818
REMARK 3 5 6.4005 - 5.9425 0.99 9665 137 0.2291 0.2718
REMARK 3 6 5.9425 - 5.5927 0.98 9583 143 0.2234 0.2782
REMARK 3 7 5.5927 - 5.3130 0.98 9597 140 0.2089 0.3180
REMARK 3 8 5.3130 - 5.0819 0.98 9655 144 0.1978 0.2372
REMARK 3 9 5.0819 - 4.8865 0.99 9651 135 0.1834 0.2008
REMARK 3 10 4.8865 - 4.7180 0.99 9606 141 0.1751 0.1874
REMARK 3 11 4.7180 - 4.5706 0.99 9746 140 0.1782 0.1852
REMARK 3 12 4.5706 - 4.4400 0.97 9533 142 0.1946 0.2392
REMARK 3 13 4.4400 - 4.3232 0.97 9466 134 0.2120 0.2411
REMARK 3 14 4.3232 - 4.2178 0.98 9678 143 0.2194 0.2519
REMARK 3 15 4.2178 - 4.1219 0.97 9509 127 0.2241 0.2857
REMARK 3 16 4.1219 - 4.0343 0.97 9611 141 0.2451 0.2951
REMARK 3 17 4.0343 - 3.9536 0.98 9562 131 0.2512 0.2892
REMARK 3 18 3.9536 - 3.8790 0.98 9634 137 0.2579 0.3524
REMARK 3 19 3.8790 - 3.8098 0.98 9638 137 0.2648 0.2822
REMARK 3 20 3.8098 - 3.7452 0.98 9705 143 0.2802 0.2835
REMARK 3 21 3.7452 - 3.6848 0.99 9701 138 0.2929 0.3305
REMARK 3 22 3.6848 - 3.6281 0.99 9580 142 0.3070 0.3095
REMARK 3 23 3.6281 - 3.5748 0.96 9497 142 0.3177 0.3290
REMARK 3 24 3.5748 - 3.5245 0.97 9444 132 0.3319 0.4396
REMARK 3 25 3.5245 - 3.4768 0.98 9638 137 0.3340 0.3986
REMARK 3 26 3.4768 - 3.4317 0.98 9591 139 0.3583 0.3445
REMARK 3 27 3.4317 - 3.3888 0.97 9513 139 0.3665 0.4304
REMARK 3 28 3.3888 - 3.3480 0.91 8999 133 0.3953 0.4489
REMARK 3
REMARK 3 BULK SOLVENT MODELLING.
REMARK 3 METHOD USED : NULL
REMARK 3 SOLVENT RADIUS : 1.11
REMARK 3 SHRINKAGE RADIUS : 0.90
REMARK 3 K_SOL : NULL
REMARK 3 B_SOL : NULL
REMARK 3
REMARK 3 ERROR ESTIMATES.
REMARK 3 COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED) : 0.520
REMARK 3 PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 28.570
REMARK 3
REMARK 3 B VALUES.
REMARK 3 FROM WILSON PLOT (A**2) : NULL
REMARK 3 MEAN B VALUE (OVERALL, A**2) : NULL
REMARK 3 OVERALL ANISOTROPIC B VALUE.
REMARK 3 B11 (A**2) : NULL
REMARK 3 B22 (A**2) : NULL
REMARK 3 B33 (A**2) : NULL
REMARK 3 B12 (A**2) : NULL
REMARK 3 B13 (A**2) : NULL
REMARK 3 B23 (A**2) : NULL
REMARK 3
REMARK 3 TWINNING INFORMATION.
REMARK 3 FRACTION: NULL
REMARK 3 OPERATOR: NULL
REMARK 3
REMARK 3 DEVIATIONS FROM IDEAL VALUES.
REMARK 3 RMSD COUNT
REMARK 3 BOND : 0.006 32366
REMARK 3 ANGLE : 0.633 43812
REMARK 3 CHIRALITY : 0.046 5094
REMARK 3 PLANARITY : 0.004 5591
REMARK 3 DIHEDRAL : 3.291 19722
REMARK 3
REMARK 3 TLS DETAILS
REMARK 3 NUMBER OF TLS GROUPS : NULL
REMARK 3
REMARK 3 NCS DETAILS
REMARK 3 NUMBER OF NCS GROUPS : NULL
REMARK 3
REMARK 3 OTHER REFINEMENT REMARKS: NULL
REMARK 4
REMARK 4 6JLZ COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ ON 13-MAR-19.
REMARK 100 THE DEPOSITION ID IS D_1300011336.
REMARK 200
REMARK 200 EXPERIMENTAL DETAILS
REMARK 200 EXPERIMENT TYPE : X-RAY DIFFRACTION
REMARK 200 DATE OF DATA COLLECTION : 25-APR-17
REMARK 200 TEMPERATURE (KELVIN) : 100
REMARK 200 PH : NULL
REMARK 200 NUMBER OF CRYSTALS USED : 1
REMARK 200
REMARK 200 SYNCHROTRON (Y/N) : Y
REMARK 200 RADIATION SOURCE : SPRING-8
REMARK 200 BEAMLINE : BL41XU
REMARK 200 X-RAY GENERATOR MODEL : NULL
REMARK 200 MONOCHROMATIC OR LAUE (M/L) : M
REMARK 200 WAVELENGTH OR RANGE (A) : 1
REMARK 200 MONOCHROMATOR : NULL
REMARK 200 OPTICS : NULL
REMARK 200
REMARK 200 DETECTOR TYPE : PIXEL
REMARK 200 DETECTOR MANUFACTURER : DECTRIS PILATUS3 S 6M
REMARK 200 INTENSITY-INTEGRATION SOFTWARE : XDS
REMARK 200 DATA SCALING SOFTWARE : XDS
REMARK 200
REMARK 200 NUMBER OF UNIQUE REFLECTIONS : 140658
REMARK 200 RESOLUTION RANGE HIGH (A) : 3.350
REMARK 200 RESOLUTION RANGE LOW (A) : 50.000
REMARK 200 REJECTION CRITERIA (SIGMA(I)) : NULL
REMARK 200
REMARK 200 OVERALL.
REMARK 200 COMPLETENESS FOR RANGE (%) : 99.7
REMARK 200 DATA REDUNDANCY : 3.500
REMARK 200 R MERGE (I) : NULL
REMARK 200 R SYM (I) : NULL
REMARK 200 <I/SIGMA(I)> FOR THE DATA SET : 12.1000
REMARK 200
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.
REMARK 200 HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 3.35
REMARK 200 HIGHEST RESOLUTION SHELL, RANGE LOW (A) : 3.55
REMARK 200 COMPLETENESS FOR SHELL (%) : NULL
REMARK 200 DATA REDUNDANCY IN SHELL : NULL
REMARK 200 R MERGE FOR SHELL (I) : NULL
REMARK 200 R SYM FOR SHELL (I) : NULL
REMARK 200 <I/SIGMA(I)> FOR SHELL : NULL
REMARK 200
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: NULL
REMARK 200 SOFTWARE USED: PHENIX
REMARK 200 STARTING MODEL: NULL
REMARK 200
REMARK 200 REMARK: NULL
REMARK 280
REMARK 280 CRYSTAL
REMARK 280 SOLVENT CONTENT, VS (%): 70.93
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 4.23
REMARK 280
REMARK 280 CRYSTALLIZATION CONDITIONS: SODIUM ACETATE, SODIUM CITRATE, PEG
REMARK 280 4000, GLYCEROL, VAPOR DIFFUSION, SITTING DROP, TEMPERATURE 293K
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 1 21 1
REMARK 290
REMARK 290 SYMOP SYMMETRY
REMARK 290 NNNMMM OPERATOR
REMARK 290 1555 X,Y,Z
REMARK 290 2555 -X,Y+1/2,-Z
REMARK 290
REMARK 290 WHERE NNN -> OPERATOR NUMBER
REMARK 290 MMM -> TRANSLATION VECTOR
REMARK 290
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY
REMARK 290 RELATED MOLECULES.
REMARK 290 SMTRY1 1 1.000000 0.000000 0.000000 0.00000
REMARK 290 SMTRY2 1 0.000000 1.000000 0.000000 0.00000
REMARK 290 SMTRY3 1 0.000000 0.000000 1.000000 0.00000
REMARK 290 SMTRY1 2 -1.000000 0.000000 0.000000 0.00000
REMARK 290 SMTRY2 2 0.000000 1.000000 0.000000 103.85600
REMARK 290 SMTRY3 2 0.000000 0.000000 -1.000000 0.00000
REMARK 290
REMARK 290 REMARK: NULL
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DODECAMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DODECAMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 46210 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 163590 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -289.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E, F, G, H, I, J,
REMARK 350 AND CHAINS: L, M
REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000
REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000
REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465 M RES C SSSEQI
REMARK 465 MET A 1
REMARK 465 VAL A 2
REMARK 465 GLU A 3
REMARK 465 SER A 4
REMARK 465 ASP A 5
REMARK 465 SER A 6
REMARK 465 SER A 7
REMARK 465 GLY A 8
REMARK 465 ILE A 9
REMARK 465 VAL A 10
REMARK 465 ARG A 11
REMARK 465 HIS A 12
REMARK 465 SER A 13
REMARK 465 PRO A 279
REMARK 465 GLU A 280
REMARK 465 PRO A 281
REMARK 465 GLU A 282
REMARK 465 PRO A 283
REMARK 465 ILE A 284
REMARK 465 PRO A 285
REMARK 465 THR A 286
REMARK 465 PRO A 287
REMARK 465 SER A 288
REMARK 465 ASP A 289
REMARK 465 MET B 1
REMARK 465 VAL B 2
REMARK 465 GLU B 3
REMARK 465 SER B 4
REMARK 465 ASP B 5
REMARK 465 SER B 6
REMARK 465 SER B 7
REMARK 465 GLY B 8
REMARK 465 ILE B 9
REMARK 465 VAL B 10
REMARK 465 ARG B 11
REMARK 465 HIS B 12
REMARK 465 SER B 13
REMARK 465 GLN B 14
REMARK 465 HIS B 278
REMARK 465 PRO B 279
REMARK 465 GLU B 280
REMARK 465 PRO B 281
REMARK 465 GLU B 282
REMARK 465 PRO B 283
REMARK 465 ILE B 284
REMARK 465 PRO B 285
REMARK 465 THR B 286
REMARK 465 PRO B 287
REMARK 465 SER B 288
REMARK 465 ASP B 289
REMARK 465 LEU C 103
REMARK 465 ILE C 104
REMARK 465 VAL C 105
REMARK 465 SER C 106
REMARK 465 SER C 107
REMARK 465 SER C 108
REMARK 465 ASN C 109
REMARK 465 SER C 110
REMARK 465 SER C 111
REMARK 465 SER C 112
REMARK 465 PRO C 113
REMARK 465 SER C 114
REMARK 465 GLN C 115
REMARK 465 LYS C 116
REMARK 465 ARG C 117
REMARK 465 ASP C 118
REMARK 465 ILE C 119
REMARK 465 PRO C 120
REMARK 465 SER C 121
REMARK 465 ASN C 122
REMARK 465 GLU C 123
REMARK 465 LYS C 124
REMARK 465 LEU C 125
REMARK 465 VAL C 126
REMARK 465 GLN C 127
REMARK 465 SER C 128
REMARK 465 HIS C 129
REMARK 465 GLU C 130
REMARK 465 PRO C 131
REMARK 465 VAL C 132
REMARK 465 SER C 133
REMARK 465 VAL C 134
REMARK 465 GLN C 135
REMARK 465 MET C 136
REMARK 465 TYR C 137
REMARK 465 SER C 138
REMARK 465 SER C 139
REMARK 465 MET C 140
REMARK 465 LEU C 141
REMARK 465 ASN C 142
REMARK 465 LEU C 143
REMARK 465 LEU C 144
REMARK 465 GLY C 145
REMARK 465 ARG C 146
REMARK 465 PRO C 147
REMARK 465 THR C 148
REMARK 465 LEU C 149
REMARK 465 GLU C 150
REMARK 465 SER C 151
REMARK 465 PRO C 152
REMARK 465 THR C 153
REMARK 465 HIS C 154
REMARK 465 SER C 155
REMARK 465 LYS C 156
REMARK 465 THR C 157
REMARK 465 VAL C 158
REMARK 465 GLY C 159
REMARK 465 ASP C 160
REMARK 465 SER C 161
REMARK 465 ARG C 162
REMARK 465 VAL C 163
REMARK 465 THR C 164
REMARK 465 LEU D 103
REMARK 465 ILE D 104
REMARK 465 VAL D 105
REMARK 465 SER D 106
REMARK 465 SER D 107
REMARK 465 SER D 108
REMARK 465 ASN D 109
REMARK 465 SER D 110
REMARK 465 SER D 111
REMARK 465 SER D 112
REMARK 465 PRO D 113
REMARK 465 SER D 114
REMARK 465 GLN D 115
REMARK 465 LYS D 116
REMARK 465 ARG D 117
REMARK 465 ASP D 118
REMARK 465 ILE D 119
REMARK 465 PRO D 120
REMARK 465 SER D 121
REMARK 465 ASN D 122
REMARK 465 GLU D 123
REMARK 465 LYS D 124
REMARK 465 LEU D 125
REMARK 465 VAL D 126
REMARK 465 GLN D 127
REMARK 465 SER D 128
REMARK 465 HIS D 129
REMARK 465 GLU D 130
REMARK 465 PRO D 131
REMARK 465 VAL D 132
REMARK 465 SER D 133
REMARK 465 VAL D 134
REMARK 465 GLN D 135
REMARK 465 MET D 136
REMARK 465 TYR D 137
REMARK 465 SER D 138
REMARK 465 SER D 139
REMARK 465 MET D 140
REMARK 465 LEU D 141
REMARK 465 ASN D 142
REMARK 465 LEU D 143
REMARK 465 LEU D 144
REMARK 465 GLY D 145
REMARK 465 ARG D 146
REMARK 465 PRO D 147
REMARK 465 THR D 148
REMARK 465 LEU D 149
REMARK 465 GLU D 150
REMARK 465 SER D 151
REMARK 465 PRO D 152
REMARK 465 THR D 153
REMARK 465 HIS D 154
REMARK 465 SER D 155
REMARK 465 LYS D 156
REMARK 465 THR D 157
REMARK 465 VAL D 158
REMARK 465 GLY D 159
REMARK 465 ASP D 160
REMARK 465 SER D 161
REMARK 465 ARG D 162
REMARK 465 VAL D 163
REMARK 465 THR D 164
REMARK 465 MET E 1
REMARK 465 SER E 2
REMARK 465 LEU E 3
REMARK 465 TYR E 4
REMARK 465 GLU E 5
REMARK 465 HIS E 6
REMARK 465 ALA E 7
REMARK 465 ALA E 8
REMARK 465 LEU E 9
REMARK 465 PRO E 10
REMARK 465 LEU E 11
REMARK 465 ALA E 12
REMARK 465 SER E 13
REMARK 465 SER E 14
REMARK 465 PRO E 15
REMARK 465 SER E 16
REMARK 465 ILE E 17
REMARK 465 LEU E 18
REMARK 465 GLY E 19
REMARK 465 PRO E 20
REMARK 465 ILE E 21
REMARK 465 SER E 22
REMARK 465 GLY E 23
REMARK 465 GLY E 24
REMARK 465 ARG E 25
REMARK 465 ASN E 26
REMARK 465 ARG E 27
REMARK 465 GLY E 28
REMARK 465 ASN E 29
REMARK 465 ILE E 30
REMARK 465 GLN E 31
REMARK 465 ASN E 293
REMARK 465 ASN E 294
REMARK 465 ILE E 295
REMARK 465 ASP E 296
REMARK 465 ASN E 297
REMARK 465 TYR E 298
REMARK 465 ASP E 299
REMARK 465 GLY E 300
REMARK 465 GLY E 301
REMARK 465 LEU E 302
REMARK 465 GLU E 451
REMARK 465 LYS E 452
REMARK 465 ILE E 453
REMARK 465 GLU E 454
REMARK 465 THR E 455
REMARK 465 ASP E 456
REMARK 465 MET E 457
REMARK 465 ASP E 458
REMARK 465 MET F 1
REMARK 465 SER F 2
REMARK 465 LEU F 3
REMARK 465 TYR F 4
REMARK 465 GLU F 5
REMARK 465 HIS F 6
REMARK 465 ALA F 7
REMARK 465 ALA F 8
REMARK 465 LEU F 9
REMARK 465 PRO F 10
REMARK 465 LEU F 11
REMARK 465 ALA F 12
REMARK 465 SER F 13
REMARK 465 SER F 14
REMARK 465 PRO F 15
REMARK 465 SER F 16
REMARK 465 ILE F 17
REMARK 465 LEU F 18
REMARK 465 GLY F 19
REMARK 465 PRO F 20
REMARK 465 ILE F 21
REMARK 465 SER F 22
REMARK 465 GLY F 23
REMARK 465 GLY F 24
REMARK 465 ARG F 25
REMARK 465 ASN F 26
REMARK 465 ARG F 27
REMARK 465 GLY F 28
REMARK 465 ASN F 29
REMARK 465 ILE F 30
REMARK 465 GLN F 31
REMARK 465 ASN F 293
REMARK 465 ASN F 294
REMARK 465 ILE F 295
REMARK 465 ASP F 296
REMARK 465 ASN F 297
REMARK 465 TYR F 298
REMARK 465 ASP F 299
REMARK 465 GLY F 300
REMARK 465 GLY F 301
REMARK 465 LEU F 302
REMARK 465 GLU F 451
REMARK 465 LYS F 452
REMARK 465 ILE F 453
REMARK 465 GLU F 454
REMARK 465 THR F 455
REMARK 465 ASP F 456
REMARK 465 MET F 457
REMARK 465 ASP F 458
REMARK 465 MET G 1
REMARK 465 GLY G 2
REMARK 465 PHE G 3
REMARK 465 SER G 4
REMARK 465 ALA G 5
REMARK 465 GLU G 6
REMARK 465 GLN G 7
REMARK 465 ALA G 8
REMARK 465 LYS G 9
REMARK 465 LYS G 10
REMARK 465 ASP G 11
REMARK 465 GLY G 12
REMARK 465 LYS G 13
REMARK 465 ASP G 14
REMARK 465 GLN G 15
REMARK 465 SER G 16
REMARK 465 PRO G 17
REMARK 465 VAL G 18
REMARK 465 SER G 19
REMARK 465 GLU G 20
REMARK 465 SER G 21
REMARK 465 SER G 22
REMARK 465 SER G 23
REMARK 465 VAL G 24
REMARK 465 GLY G 25
REMARK 465 GLY G 26
REMARK 465 THR G 27
REMARK 465 SER G 28
REMARK 465 PRO G 29
REMARK 465 ALA G 30
REMARK 465 THR G 31
REMARK 465 ALA G 32
REMARK 465 SER G 33
REMARK 465 SER G 34
REMARK 465 VAL G 35
REMARK 465 VAL G 36
REMARK 465 SER G 37
REMARK 465 PRO G 38
REMARK 465 ASN G 39
REMARK 465 GLU G 40
REMARK 465 PRO G 41
REMARK 465 LYS G 42
REMARK 465 LEU G 43
REMARK 465 SER G 44
REMARK 465 GLY G 45
REMARK 465 LYS G 46
REMARK 465 GLU G 47
REMARK 465 ALA G 48
REMARK 465 LYS G 49
REMARK 465 ALA G 50
REMARK 465 LEU G 51
REMARK 465 LYS G 52
REMARK 465 LYS G 53
REMARK 465 ALA G 54
REMARK 465 ARG G 55
REMARK 465 LYS G 56
REMARK 465 GLN G 57
REMARK 465 ALA G 58
REMARK 465 SER G 59
REMARK 465 ARG G 60
REMARK 465 ARG G 61
REMARK 465 ALA G 62
REMARK 465 LYS G 63
REMARK 465 ALA G 64
REMARK 465 GLU G 65
REMARK 465 ALA G 66
REMARK 465 ALA G 67
REMARK 465 ALA G 68
REMARK 465 ALA G 69
REMARK 465 ASN G 70
REMARK 465 ASN G 71
REMARK 465 PRO G 72
REMARK 465 PRO G 73
REMARK 465 GLY G 74
REMARK 465 VAL G 75
REMARK 465 SER G 76
REMARK 465 GLU G 77
REMARK 465 GLU G 78
REMARK 465 LYS G 79
REMARK 465 LYS G 80
REMARK 465 VAL G 81
REMARK 465 ALA G 82
REMARK 465 ILE G 83
REMARK 465 PRO G 84
REMARK 465 ASN G 85
REMARK 465 LYS G 86
REMARK 465 ASN G 87
REMARK 465 SER G 88
REMARK 465 ASN G 89
REMARK 465 GLN G 90
REMARK 465 GLN G 91
REMARK 465 LYS G 92
REMARK 465 LYS G 93
REMARK 465 ALA G 94
REMARK 465 SER G 95
REMARK 465 LYS G 96
REMARK 465 GLN G 97
REMARK 465 ASN G 98
REMARK 465 PRO G 99
REMARK 465 GLN G 100
REMARK 465 ASN G 101
REMARK 465 SER G 102
REMARK 465 PRO G 103
REMARK 465 GLU G 104
REMARK 465 THR G 105
REMARK 465 TYR G 466
REMARK 465 ALA G 467
REMARK 465 MET H 1
REMARK 465 GLY H 2
REMARK 465 PHE H 3
REMARK 465 SER H 4
REMARK 465 ALA H 5
REMARK 465 GLU H 6
REMARK 465 GLN H 7
REMARK 465 ALA H 8
REMARK 465 LYS H 9
REMARK 465 LYS H 10
REMARK 465 ASP H 11
REMARK 465 GLY H 12
REMARK 465 LYS H 13
REMARK 465 ASP H 14
REMARK 465 GLN H 15
REMARK 465 SER H 16
REMARK 465 PRO H 17
REMARK 465 VAL H 18
REMARK 465 SER H 19
REMARK 465 GLU H 20
REMARK 465 SER H 21
REMARK 465 SER H 22
REMARK 465 SER H 23
REMARK 465 VAL H 24
REMARK 465 GLY H 25
REMARK 465 GLY H 26
REMARK 465 THR H 27
REMARK 465 SER H 28
REMARK 465 PRO H 29
REMARK 465 ALA H 30
REMARK 465 THR H 31
REMARK 465 ALA H 32
REMARK 465 SER H 33
REMARK 465 SER H 34
REMARK 465 VAL H 35
REMARK 465 VAL H 36
REMARK 465 SER H 37
REMARK 465 PRO H 38
REMARK 465 ASN H 39
REMARK 465 GLU H 40
REMARK 465 PRO H 41
REMARK 465 LYS H 42
REMARK 465 LEU H 43
REMARK 465 SER H 44
REMARK 465 GLY H 45
REMARK 465 LYS H 46
REMARK 465 GLU H 47
REMARK 465 ALA H 48
REMARK 465 LYS H 49
REMARK 465 ALA H 50
REMARK 465 LEU H 51
REMARK 465 LYS H 52
REMARK 465 LYS H 53
REMARK 465 ALA H 54
REMARK 465 ARG H 55
REMARK 465 LYS H 56
REMARK 465 GLN H 57
REMARK 465 ALA H 58
REMARK 465 SER H 59
REMARK 465 ARG H 60
REMARK 465 ARG H 61
REMARK 465 ALA H 62
REMARK 465 LYS H 63
REMARK 465 ALA H 64
REMARK 465 GLU H 65
REMARK 465 ALA H 66
REMARK 465 ALA H 67
REMARK 465 ALA H 68
REMARK 465 ALA H 69
REMARK 465 ASN H 70
REMARK 465 ASN H 71
REMARK 465 PRO H 72
REMARK 465 PRO H 73
REMARK 465 GLY H 74
REMARK 465 VAL H 75
REMARK 465 SER H 76
REMARK 465 GLU H 77
REMARK 465 GLU H 78
REMARK 465 LYS H 79
REMARK 465 LYS H 80
REMARK 465 VAL H 81
REMARK 465 ALA H 82
REMARK 465 ILE H 83
REMARK 465 PRO H 84
REMARK 465 ASN H 85
REMARK 465 LYS H 86
REMARK 465 ASN H 87
REMARK 465 SER H 88
REMARK 465 ASN H 89
REMARK 465 GLN H 90
REMARK 465 GLN H 91
REMARK 465 LYS H 92
REMARK 465 LYS H 93
REMARK 465 ALA H 94
REMARK 465 SER H 95
REMARK 465 LYS H 96
REMARK 465 GLN H 97
REMARK 465 ASN H 98
REMARK 465 PRO H 99
REMARK 465 GLN H 100
REMARK 465 ASN H 101
REMARK 465 SER H 102
REMARK 465 PRO H 103
REMARK 465 GLU H 104
REMARK 465 THR H 105
REMARK 465 ALA H 467
REMARK 465 MET I 1
REMARK 465 PRO I 2
REMARK 465 PRO I 3
REMARK 465 SER I 4
REMARK 465 LYS I 5
REMARK 465 GLY I 6
REMARK 465 LEU I 7
REMARK 465 ASN I 8
REMARK 465 GLY I 9
REMARK 465 LYS I 10
REMARK 465 LEU I 11
REMARK 465 GLU I 12
REMARK 465 GLY I 443
REMARK 465 GLN I 444
REMARK 465 GLU I 445
REMARK 465 TYR I 446
REMARK 465 HIS I 447
REMARK 465 ALA I 448
REMARK 465 GLU I 449
REMARK 465 GLU I 450
REMARK 465 ASP I 451
REMARK 465 SER I 452
REMARK 465 ASP I 453
REMARK 465 ASP I 454
REMARK 465 GLU I 455
REMARK 465 GLY I 456
REMARK 465 GLU I 457
REMARK 465 PHE I 458
REMARK 465 MET I 459
REMARK 465 GLU I 460
REMARK 465 ALA I 461
REMARK 465 SER I 462
REMARK 465 GLY I 463
REMARK 465 LEU I 464
REMARK 465 ILE I 465
REMARK 465 GLU I 466
REMARK 465 SER I 467
REMARK 465 THR I 468
REMARK 465 ASN I 469
REMARK 465 GLU I 470
REMARK 465 LEU I 471
REMARK 465 HIS I 472
REMARK 465 LEU I 473
REMARK 465 SER I 474
REMARK 465 ASP I 475
REMARK 465 SER I 476
REMARK 465 GLU I 477
REMARK 465 SER I 478
REMARK 465 SER I 479
REMARK 465 GLU I 480
REMARK 465 THR I 481
REMARK 465 SER I 482
REMARK 465 SER I 483
REMARK 465 SER I 484
REMARK 465 SER I 485
REMARK 465 GLU I 486
REMARK 465 GLU I 487
REMARK 465 ASP I 488
REMARK 465 MET I 489
REMARK 465 GLU I 490
REMARK 465 PHE I 491
REMARK 465 ILE I 492
REMARK 465 PRO I 493
REMARK 465 PHE I 494
REMARK 465 SER I 495
REMARK 465 ALA I 496
REMARK 465 ARG I 497
REMARK 465 ARG I 498
REMARK 465 ASP I 499
REMARK 465 SER I 500
REMARK 465 ALA I 501
REMARK 465 ASN I 502
REMARK 465 THR I 503
REMARK 465 ILE I 504
REMARK 465 ASN I 505
REMARK 465 SER I 506
REMARK 465 GLU I 507
REMARK 465 ASP I 508
REMARK 465 PHE I 509
REMARK 465 ASP I 510
REMARK 465 GLU I 511
REMARK 465 GLY I 512
REMARK 465 ASP I 513
REMARK 465 PHE I 514
REMARK 465 ASN I 515
REMARK 465 LYS I 516
REMARK 465 GLU I 517
REMARK 465 ALA I 518
REMARK 465 GLN I 519
REMARK 465 GLN I 520
REMARK 465 SER I 521
REMARK 465 LEU I 522
REMARK 465 GLU I 523
REMARK 465 ARG I 524
REMARK 465 ALA I 525
REMARK 465 PHE I 526
REMARK 465 GLU I 527
REMARK 465 GLU I 528
REMARK 465 ASN I 529
REMARK 465 HIS I 530
REMARK 465 GLN I 531
REMARK 465 ILE I 532
REMARK 465 ASP I 533
REMARK 465 ILE I 534
REMARK 465 ALA I 535
REMARK 465 ALA I 536
REMARK 465 LEU I 537
REMARK 465 GLU I 538
REMARK 465 LEU I 539
REMARK 465 ASN I 540
REMARK 465 THR I 541
REMARK 465 LEU I 542
REMARK 465 ARG I 543
REMARK 465 MET I 544
REMARK 465 ALA I 545
REMARK 465 MET I 546
REMARK 465 ASN I 547
REMARK 465 ALA I 548
REMARK 465 ASN I 549
REMARK 465 TYR I 550
REMARK 465 HIS I 551
REMARK 465 GLU I 552
REMARK 465 VAL I 553
REMARK 465 ARG I 554
REMARK 465 SER I 555
REMARK 465 ALA I 556
REMARK 465 ILE I 557
REMARK 465 VAL I 558
REMARK 465 LEU I 559
REMARK 465 ALA I 560
REMARK 465 LEU I 561
REMARK 465 LEU I 562
REMARK 465 ARG I 563
REMARK 465 ARG I 564
REMARK 465 ILE I 565
REMARK 465 MET I 566
REMARK 465 HIS I 567
REMARK 465 LEU I 568
REMARK 465 ASP I 569
REMARK 465 VAL I 570
REMARK 465 SER I 571
REMARK 465 PRO I 572
REMARK 465 LYS I 573
REMARK 465 GLU I 574
REMARK 465 ALA I 575
REMARK 465 LEU I 576
REMARK 465 ALA I 577
REMARK 465 LYS I 578
REMARK 465 VAL I 579
REMARK 465 MET I 580
REMARK 465 THR I 581
REMARK 465 ARG I 582
REMARK 465 TRP I 583
REMARK 465 GLY I 584
REMARK 465 PRO I 585
REMARK 465 LEU I 586
REMARK 465 LEU I 587
REMARK 465 ALA I 588
REMARK 465 LYS I 589
REMARK 465 LEU I 590
REMARK 465 THR I 591
REMARK 465 PHE I 592
REMARK 465 SER I 593
REMARK 465 HIS I 594
REMARK 465 GLU I 595
REMARK 465 GLU I 596
REMARK 465 GLN I 597
REMARK 465 VAL I 598
REMARK 465 ASP I 599
REMARK 465 ASN I 600
REMARK 465 VAL I 601
REMARK 465 LEU I 602
REMARK 465 THR I 603
REMARK 465 LEU I 604
REMARK 465 GLN I 605
REMARK 465 LYS I 606
REMARK 465 TYR I 607
REMARK 465 CYS I 608
REMARK 465 VAL I 609
REMARK 465 ARG I 610
REMARK 465 LEU I 611
REMARK 465 SER I 612
REMARK 465 MET I 613
REMARK 465 THR I 614
REMARK 465 ARG I 615
REMARK 465 HIS I 616
REMARK 465 PHE I 617
REMARK 465 LEU I 618
REMARK 465 GLN I 619
REMARK 465 LEU I 620
REMARK 465 LEU I 621
REMARK 465 GLY I 622
REMARK 465 TYR I 623
REMARK 465 PHE I 624
REMARK 465 TYR I 625
REMARK 465 GLN I 626
REMARK 465 LEU I 627
REMARK 465 GLU I 628
REMARK 465 ILE I 629
REMARK 465 ALA I 630
REMARK 465 GLU I 631
REMARK 465 GLU I 632
REMARK 465 ASN I 633
REMARK 465 ALA I 634
REMARK 465 ILE I 635
REMARK 465 GLN I 636
REMARK 465 GLU I 637
REMARK 465 TRP I 638
REMARK 465 TYR I 639
REMARK 465 SER I 640
REMARK 465 ASP I 641
REMARK 465 PRO I 642
REMARK 465 ARG I 643
REMARK 465 SER I 644
REMARK 465 SER I 645
REMARK 465 GLU I 646
REMARK 465 GLY I 647
REMARK 465 GLU I 648
REMARK 465 LEU I 649
REMARK 465 ALA I 650
REMARK 465 ALA I 651
REMARK 465 LEU I 652
REMARK 465 ARG I 653
REMARK 465 ASP I 654
REMARK 465 ALA I 655
REMARK 465 GLY I 656
REMARK 465 GLY I 657
REMARK 465 LYS I 658
REMARK 465 GLN I 659
REMARK 465 PHE I 660
REMARK 465 VAL I 661
REMARK 465 ASP I 662
REMARK 465 TRP I 663
REMARK 465 LEU I 664
REMARK 465 ASN I 665
REMARK 465 THR I 666
REMARK 465 ALA I 667
REMARK 465 GLU I 668
REMARK 465 SER I 669
REMARK 465 GLU I 670
REMARK 465 SER I 671
REMARK 465 GLU I 672
REMARK 465 SER I 673
REMARK 465 GLU I 674
REMARK 465 GLU I 675
REMARK 465 GLY I 676
REMARK 465 SER I 677
REMARK 465 GLU I 678
REMARK 465 MET J 1
REMARK 465 PRO J 2
REMARK 465 PRO J 3
REMARK 465 SER J 4
REMARK 465 LYS J 5
REMARK 465 GLY J 6
REMARK 465 LEU J 7
REMARK 465 ASN J 8
REMARK 465 GLY J 9
REMARK 465 LYS J 10
REMARK 465 LEU J 11
REMARK 465 GLU J 12
REMARK 465 LYS J 13
REMARK 465 PRO J 14
REMARK 465 GLY J 443
REMARK 465 GLN J 444
REMARK 465 GLU J 445
REMARK 465 TYR J 446
REMARK 465 HIS J 447
REMARK 465 ALA J 448
REMARK 465 GLU J 449
REMARK 465 GLU J 450
REMARK 465 ASP J 451
REMARK 465 SER J 452
REMARK 465 ASP J 453
REMARK 465 ASP J 454
REMARK 465 GLU J 455
REMARK 465 GLY J 456
REMARK 465 GLU J 457
REMARK 465 PHE J 458
REMARK 465 MET J 459
REMARK 465 GLU J 460
REMARK 465 ALA J 461
REMARK 465 SER J 462
REMARK 465 GLY J 463
REMARK 465 LEU J 464
REMARK 465 ILE J 465
REMARK 465 GLU J 466
REMARK 465 SER J 467
REMARK 465 THR J 468
REMARK 465 ASN J 469
REMARK 465 GLU J 470
REMARK 465 LEU J 471
REMARK 465 HIS J 472
REMARK 465 LEU J 473
REMARK 465 SER J 474
REMARK 465 ASP J 475
REMARK 465 SER J 476
REMARK 465 GLU J 477
REMARK 465 SER J 478
REMARK 465 SER J 479
REMARK 465 GLU J 480
REMARK 465 THR J 481
REMARK 465 SER J 482
REMARK 465 SER J 483
REMARK 465 SER J 484
REMARK 465 SER J 485
REMARK 465 GLU J 486
REMARK 465 GLU J 487
REMARK 465 ASP J 488
REMARK 465 MET J 489
REMARK 465 GLU J 490
REMARK 465 PHE J 491
REMARK 465 ILE J 492
REMARK 465 PRO J 493
REMARK 465 PHE J 494
REMARK 465 SER J 495
REMARK 465 ALA J 496
REMARK 465 ARG J 497
REMARK 465 ARG J 498
REMARK 465 ASP J 499
REMARK 465 SER J 500
REMARK 465 ALA J 501
REMARK 465 ASN J 502
REMARK 465 THR J 503
REMARK 465 ILE J 504
REMARK 465 ASN J 505
REMARK 465 SER J 506
REMARK 465 GLU J 507
REMARK 465 ASP J 508
REMARK 465 PHE J 509
REMARK 465 ASP J 510
REMARK 465 GLU J 511
REMARK 465 GLY J 512
REMARK 465 ASP J 513
REMARK 465 PHE J 514
REMARK 465 ASN J 515
REMARK 465 LYS J 516
REMARK 465 GLU J 517
REMARK 465 ALA J 518
REMARK 465 GLN J 519
REMARK 465 GLN J 520
REMARK 465 SER J 521
REMARK 465 LEU J 522
REMARK 465 GLU J 523
REMARK 465 ARG J 524
REMARK 465 ALA J 525
REMARK 465 PHE J 526
REMARK 465 GLU J 527
REMARK 465 GLU J 528
REMARK 465 ASN J 529
REMARK 465 HIS J 530
REMARK 465 GLN J 531
REMARK 465 ILE J 532
REMARK 465 ASP J 533
REMARK 465 ILE J 534
REMARK 465 ALA J 535
REMARK 465 ALA J 536
REMARK 465 LEU J 537
REMARK 465 GLU J 538
REMARK 465 LEU J 539
REMARK 465 ASN J 540
REMARK 465 THR J 541
REMARK 465 LEU J 542
REMARK 465 ARG J 543
REMARK 465 MET J 544
REMARK 465 ALA J 545
REMARK 465 MET J 546
REMARK 465 ASN J 547
REMARK 465 ALA J 548
REMARK 465 ASN J 549
REMARK 465 TYR J 550
REMARK 465 HIS J 551
REMARK 465 GLU J 552
REMARK 465 VAL J 553
REMARK 465 ARG J 554
REMARK 465 SER J 555
REMARK 465 ALA J 556
REMARK 465 ILE J 557
REMARK 465 VAL J 558
REMARK 465 LEU J 559
REMARK 465 ALA J 560
REMARK 465 LEU J 561
REMARK 465 LEU J 562
REMARK 465 ARG J 563
REMARK 465 ARG J 564
REMARK 465 ILE J 565
REMARK 465 MET J 566
REMARK 465 HIS J 567
REMARK 465 LEU J 568
REMARK 465 ASP J 569
REMARK 465 VAL J 570
REMARK 465 SER J 571
REMARK 465 PRO J 572
REMARK 465 LYS J 573
REMARK 465 GLU J 574
REMARK 465 ALA J 575
REMARK 465 LEU J 576
REMARK 465 ALA J 577
REMARK 465 LYS J 578
REMARK 465 VAL J 579
REMARK 465 MET J 580
REMARK 465 THR J 581
REMARK 465 ARG J 582
REMARK 465 TRP J 583
REMARK 465 GLY J 584
REMARK 465 PRO J 585
REMARK 465 LEU J 586
REMARK 465 LEU J 587
REMARK 465 ALA J 588
REMARK 465 LYS J 589
REMARK 465 LEU J 590
REMARK 465 THR J 591
REMARK 465 PHE J 592
REMARK 465 SER J 593
REMARK 465 HIS J 594
REMARK 465 GLU J 595
REMARK 465 GLU J 596
REMARK 465 GLN J 597
REMARK 465 VAL J 598
REMARK 465 ASP J 599
REMARK 465 ASN J 600
REMARK 465 VAL J 601
REMARK 465 LEU J 602
REMARK 465 THR J 603
REMARK 465 LEU J 604
REMARK 465 GLN J 605
REMARK 465 LYS J 606
REMARK 465 TYR J 607
REMARK 465 CYS J 608
REMARK 465 VAL J 609
REMARK 465 ARG J 610
REMARK 465 LEU J 611
REMARK 465 SER J 612
REMARK 465 MET J 613
REMARK 465 THR J 614
REMARK 465 ARG J 615
REMARK 465 HIS J 616
REMARK 465 PHE J 617
REMARK 465 LEU J 618
REMARK 465 GLN J 619
REMARK 465 LEU J 620
REMARK 465 LEU J 621
REMARK 465 GLY J 622
REMARK 465 TYR J 623
REMARK 465 PHE J 624
REMARK 465 TYR J 625
REMARK 465 GLN J 626
REMARK 465 LEU J 627
REMARK 465 GLU J 628
REMARK 465 ILE J 629
REMARK 465 ALA J 630
REMARK 465 GLU J 631
REMARK 465 GLU J 632
REMARK 465 ASN J 633
REMARK 465 ALA J 634
REMARK 465 ILE J 635
REMARK 465 GLN J 636
REMARK 465 GLU J 637
REMARK 465 TRP J 638
REMARK 465 TYR J 639
REMARK 465 SER J 640
REMARK 465 ASP J 641
REMARK 465 PRO J 642
REMARK 465 ARG J 643
REMARK 465 SER J 644
REMARK 465 SER J 645
REMARK 465 GLU J 646
REMARK 465 GLY J 647
REMARK 465 GLU J 648
REMARK 465 LEU J 649
REMARK 465 ALA J 650
REMARK 465 ALA J 651
REMARK 465 LEU J 652
REMARK 465 ARG J 653
REMARK 465 ASP J 654
REMARK 465 ALA J 655
REMARK 465 GLY J 656
REMARK 465 GLY J 657
REMARK 465 LYS J 658
REMARK 465 GLN J 659
REMARK 465 PHE J 660
REMARK 465 VAL J 661
REMARK 465 ASP J 662
REMARK 465 TRP J 663
REMARK 465 LEU J 664
REMARK 465 ASN J 665
REMARK 465 THR J 666
REMARK 465 ALA J 667
REMARK 465 GLU J 668
REMARK 465 SER J 669
REMARK 465 GLU J 670
REMARK 465 SER J 671
REMARK 465 GLU J 672
REMARK 465 SER J 673
REMARK 465 GLU J 674
REMARK 465 GLU J 675
REMARK 465 GLY J 676
REMARK 465 SER J 677
REMARK 465 GLU J 678
REMARK 465 MET L 0
REMARK 465 SER L 1
REMARK 465 THR L 2
REMARK 465 SER L 3
REMARK 465 LYS L 117
REMARK 465 PHE L 118
REMARK 465 GLN L 119
REMARK 465 ILE L 120
REMARK 465 PRO L 121
REMARK 465 LEU L 176
REMARK 465 THR L 177
REMARK 465 PRO L 178
REMARK 465 GLN L 179
REMARK 465 ALA L 180
REMARK 465 VAL L 181
REMARK 465 LYS L 182
REMARK 465 ILE L 183
REMARK 465 ARG L 184
REMARK 465 ALA L 185
REMARK 465 ASP L 186
REMARK 465 VAL L 187
REMARK 465 GLU L 188
REMARK 465 VAL L 189
REMARK 465 SER L 190
REMARK 465 CYS L 191
REMARK 465 PHE L 192
REMARK 465 SER L 193
REMARK 465 TYR L 194
REMARK 465 GLU L 195
REMARK 465 GLY L 196
REMARK 465 ILE L 197
REMARK 465 ASP L 198
REMARK 465 ALA L 199
REMARK 465 ILE L 200
REMARK 465 LYS L 201
REMARK 465 ASP L 202
REMARK 465 ALA L 203
REMARK 465 LEU L 204
REMARK 465 LYS L 205
REMARK 465 SER L 206
REMARK 465 ALA L 207
REMARK 465 GLU L 208
REMARK 465 ASP L 209
REMARK 465 MET L 210
REMARK 465 SER L 211
REMARK 465 THR L 212
REMARK 465 GLU L 213
REMARK 465 GLN L 214
REMARK 465 MET L 215
REMARK 465 GLN L 216
REMARK 465 VAL L 217
REMARK 465 LYS L 218
REMARK 465 VAL L 219
REMARK 465 LYS L 220
REMARK 465 LEU L 221
REMARK 465 VAL L 222
REMARK 465 ALA L 223
REMARK 465 ALA L 224
REMARK 465 PRO L 225
REMARK 465 LEU L 226
REMARK 465 TYR L 227
REMARK 465 VAL L 228
REMARK 465 LEU L 229
REMARK 465 THR L 230
REMARK 465 THR L 231
REMARK 465 GLN L 232
REMARK 465 ALA L 233
REMARK 465 LEU L 234
REMARK 465 ASP L 235
REMARK 465 LYS L 236
REMARK 465 GLN L 237
REMARK 465 LYS L 238
REMARK 465 GLY L 239
REMARK 465 ILE L 240
REMARK 465 GLU L 241
REMARK 465 GLN L 242
REMARK 465 LEU L 243
REMARK 465 GLU L 244
REMARK 465 SER L 245
REMARK 465 ALA L 246
REMARK 465 ILE L 247
REMARK 465 GLU L 248
REMARK 465 LYS L 249
REMARK 465 ILE L 250
REMARK 465 THR L 251
REMARK 465 GLU L 252
REMARK 465 VAL L 253
REMARK 465 ILE L 254
REMARK 465 THR L 255
REMARK 465 LYS L 256
REMARK 465 TYR L 257
REMARK 465 GLY L 258
REMARK 465 GLY L 259
REMARK 465 VAL L 260
REMARK 465 CYS L 261
REMARK 465 ASN L 262
REMARK 465 ILE L 263
REMARK 465 THR L 264
REMARK 465 MET L 265
REMARK 465 PRO L 266
REMARK 465 PRO L 267
REMARK 465 LYS L 268
REMARK 465 ALA L 269
REMARK 465 VAL L 270
REMARK 465 THR L 271
REMARK 465 ALA L 272
REMARK 465 THR L 273
REMARK 465 GLU L 274
REMARK 465 ASP L 275
REMARK 465 ALA L 276
REMARK 465 GLU L 277
REMARK 465 LEU L 278
REMARK 465 GLN L 279
REMARK 465 ALA L 280
REMARK 465 LEU L 281
REMARK 465 LEU L 282
REMARK 465 GLU L 283
REMARK 465 SER L 284
REMARK 465 LYS L 285
REMARK 465 GLU L 286
REMARK 465 LEU L 287
REMARK 465 ASP L 288
REMARK 465 ASN L 289
REMARK 465 ARG L 290
REMARK 465 SER L 291
REMARK 465 ASP L 292
REMARK 465 SER L 293
REMARK 465 GLU L 294
REMARK 465 ASP L 295
REMARK 465 ASP L 296
REMARK 465 GLU L 297
REMARK 465 ASP L 298
REMARK 465 GLU L 299
REMARK 465 SER L 300
REMARK 465 ASP L 301
REMARK 465 ASP L 302
REMARK 465 GLU L 303
REMARK 465 MET M 0
REMARK 465 SER M 1
REMARK 465 LYS M 117
REMARK 465 PHE M 118
REMARK 465 GLN M 119
REMARK 465 ILE M 120
REMARK 465 PRO M 121
REMARK 465 LEU M 176
REMARK 465 THR M 177
REMARK 465 PRO M 178
REMARK 465 GLN M 179
REMARK 465 ALA M 180
REMARK 465 VAL M 181
REMARK 465 LYS M 182
REMARK 465 ILE M 183
REMARK 465 ARG M 184
REMARK 465 ALA M 185
REMARK 465 ASP M 186
REMARK 465 VAL M 187
REMARK 465 GLU M 188
REMARK 465 VAL M 189
REMARK 465 SER M 190
REMARK 465 CYS M 191
REMARK 465 PHE M 192
REMARK 465 SER M 193
REMARK 465 TYR M 194
REMARK 465 GLU M 195
REMARK 465 GLY M 196
REMARK 465 ILE M 197
REMARK 465 ASP M 198
REMARK 465 ALA M 199
REMARK 465 ILE M 200
REMARK 465 LYS M 201
REMARK 465 ASP M 202
REMARK 465 ALA M 203
REMARK 465 LEU M 204
REMARK 465 LYS M 205
REMARK 465 SER M 206
REMARK 465 ALA M 207
REMARK 465 GLU M 208
REMARK 465 ASP M 209
REMARK 465 MET M 210
REMARK 465 SER M 211
REMARK 465 THR M 212
REMARK 465 GLU M 213
REMARK 465 GLN M 214
REMARK 465 MET M 215
REMARK 465 GLN M 216
REMARK 465 VAL M 217
REMARK 465 LYS M 218
REMARK 465 VAL M 219
REMARK 465 LYS M 220
REMARK 465 LEU M 221
REMARK 465 VAL M 222
REMARK 465 ALA M 223
REMARK 465 ALA M 224
REMARK 465 PRO M 225
REMARK 465 LEU M 226
REMARK 465 TYR M 227
REMARK 465 VAL M 228
REMARK 465 LEU M 229
REMARK 465 THR M 230
REMARK 465 THR M 231
REMARK 465 GLN M 232
REMARK 465 ALA M 233
REMARK 465 LEU M 234
REMARK 465 ASP M 235
REMARK 465 LYS M 236
REMARK 465 GLN M 237
REMARK 465 LYS M 238
REMARK 465 GLY M 239
REMARK 465 ILE M 240
REMARK 465 GLU M 241
REMARK 465 GLN M 242
REMARK 465 LEU M 243
REMARK 465 GLU M 244
REMARK 465 SER M 245
REMARK 465 ALA M 246
REMARK 465 ILE M 247
REMARK 465 GLU M 248
REMARK 465 LYS M 249
REMARK 465 ILE M 250
REMARK 465 THR M 251
REMARK 465 GLU M 252
REMARK 465 VAL M 253
REMARK 465 ILE M 254
REMARK 465 THR M 255
REMARK 465 LYS M 256
REMARK 465 TYR M 257
REMARK 465 GLY M 258
REMARK 465 GLY M 259
REMARK 465 VAL M 260
REMARK 465 CYS M 261
REMARK 465 ASN M 262
REMARK 465 ILE M 263
REMARK 465 THR M 264
REMARK 465 MET M 265
REMARK 465 PRO M 266
REMARK 465 PRO M 267
REMARK 465 LYS M 268
REMARK 465 ALA M 269
REMARK 465 VAL M 270
REMARK 465 THR M 271
REMARK 465 ALA M 272
REMARK 465 THR M 273
REMARK 465 GLU M 274
REMARK 465 ASP M 275
REMARK 465 ALA M 276
REMARK 465 GLU M 277
REMARK 465 LEU M 278
REMARK 465 GLN M 279
REMARK 465 ALA M 280
REMARK 465 LEU M 281
REMARK 465 LEU M 282
REMARK 465 GLU M 283
REMARK 465 SER M 284
REMARK 465 LYS M 285
REMARK 465 GLU M 286
REMARK 465 LEU M 287
REMARK 465 ASP M 288
REMARK 465 ASN M 289
REMARK 465 ARG M 290
REMARK 465 SER M 291
REMARK 465 ASP M 292
REMARK 465 SER M 293
REMARK 465 GLU M 294
REMARK 465 ASP M 295
REMARK 465 ASP M 296
REMARK 465 GLU M 297
REMARK 465 ASP M 298
REMARK 465 GLU M 299
REMARK 465 SER M 300
REMARK 465 ASP M 301
REMARK 465 ASP M 302
REMARK 465 GLU M 303
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT
REMARK 500
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.
REMARK 500
REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI DISTANCE
REMARK 500 O1P SEP M 51 NH2 ARG M 63 1.30
REMARK 500 P SEP M 51 NH2 ARG M 63 1.83
REMARK 500 NH1 ARG I 290 OD2 ASP I 298 1.90
REMARK 500 OG SER H 359 OD2 ASP H 433 1.90
REMARK 500 OH TYR F 329 OE2 GLU F 429 1.92
REMARK 500 OE2 GLU J 65 OH TYR J 67 1.92
REMARK 500 OE2 GLU A 216 NH1 ARG A 251 1.93
REMARK 500 OE2 GLU I 65 OH TYR I 67 1.94
REMARK 500 OH TYR E 329 OE2 GLU E 429 1.95
REMARK 500 OG SER B 56 OD1 ASP L 83 1.95
REMARK 500 OE2 GLU E 199 OG1 THR E 202 1.96
REMARK 500 OE2 GLU H 240 OG SER H 244 1.97
REMARK 500 OG SER A 56 OD1 ASP M 83 1.98
REMARK 500 OD1 ASP J 242 N LYS J 245 1.99
REMARK 500 OG SER G 378 OE2 GLU G 446 1.99
REMARK 500 OG SER H 378 OE2 GLU H 446 2.00
REMARK 500 OG SER D 338 OD1 ASN D 340 2.00
REMARK 500 NH2 ARG E 230 OE2 GLU J 213 2.01
REMARK 500 OE2 GLU I 56 NZ LYS I 85 2.01
REMARK 500 O1P SEP M 51 CZ ARG M 63 2.02
REMARK 500 OG SER J 105 OD2 ASP J 108 2.02
REMARK 500 NZ LYS H 312 OE2 GLU H 316 2.04
REMARK 500 OD1 ASP I 242 N LYS I 245 2.05
REMARK 500 OE2 GLU B 216 NE ARG B 251 2.05
REMARK 500 OE2 GLU D 7 OG SER J 90 2.06
REMARK 500 OE2 GLU I 52 OH TYR I 80 2.07
REMARK 500 O ILE C 381 OG1 THR C 385 2.08
REMARK 500 OD2 ASP I 150 NZ LYS I 260 2.09
REMARK 500 OD1 ASP F 123 N SER F 125 2.09
REMARK 500 O GLY I 409 OG1 THR I 412 2.10
REMARK 500 OH TYR F 180 OE2 GLU F 331 2.10
REMARK 500 OG SER E 147 OD1 ASP E 149 2.10
REMARK 500 O TYR I 280 OG SER I 284 2.11
REMARK 500 OD2 ASP H 399 NZ LYS H 420 2.12
REMARK 500 OD2 ASP B 259 NZ LYS H 264 2.12
REMARK 500 O ARG B 134 OG SER B 137 2.12
REMARK 500 O PRO H 451 OG SER H 454 2.13
REMARK 500 OG SER G 359 OD2 ASP G 433 2.13
REMARK 500 O ARG A 134 OG SER A 137 2.13
REMARK 500 O GLY J 409 OG1 THR J 412 2.14
REMARK 500 NH1 ARG J 111 O PHE J 234 2.14
REMARK 500 NH1 ARG G 384 OE1 GLN G 386 2.14
REMARK 500 OE2 GLU J 52 OH TYR J 80 2.15
REMARK 500 OH TYR H 178 O HIS H 189 2.15
REMARK 500 O LEU A 46 OG SER A 50 2.15
REMARK 500 O ASN J 432 OG SER J 435 2.15
REMARK 500 OD1 ASN G 161 OH TYR G 379 2.16
REMARK 500 OD2 ASP L 68 CE LYS L 86 2.16
REMARK 500 OG SER H 348 O THR H 382 2.16
REMARK 500 NE2 GLN D 178 OD1 ASP D 182 2.16
REMARK 500
REMARK 500 THIS ENTRY HAS 71 CLOSE CONTACTS
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS
REMARK 500
REMARK 500 THE FOLLOWING ATOMS THAT ARE RELATED BY CRYSTALLOGRAPHIC
REMARK 500 SYMMETRY ARE IN CLOSE CONTACT. AN ATOM LOCATED WITHIN 0.15
REMARK 500 ANGSTROMS OF A SYMMETRY RELATED ATOM IS ASSUMED TO BE ON A
REMARK 500 SPECIAL POSITION AND IS, THEREFORE, LISTED IN REMARK 375
REMARK 500 INSTEAD OF REMARK 500. ATOMS WITH NON-BLANK ALTERNATE
REMARK 500 LOCATION INDICATORS ARE NOT INCLUDED IN THE CALCULATIONS.
REMARK 500
REMARK 500 DISTANCE CUTOFF:
REMARK 500 2.2 ANGSTROMS FOR CONTACTS NOT INVOLVING HYDROGEN ATOMS
REMARK 500 1.6 ANGSTROMS FOR CONTACTS INVOLVING HYDROGEN ATOMS
REMARK 500
REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI SSYMOP DISTANCE
REMARK 500 OG1 THR F 367 OE2 GLU L 14 1556 2.03
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)
REMARK 500
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996
REMARK 500
REMARK 500 M RES CSSEQI ATM1 ATM2 ATM3
REMARK 500 PRO F 292 C - N - CA ANGL. DEV. = 9.3 DEGREES
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500 M RES CSSEQI PSI PHI
REMARK 500 PHE A 17 -178.91 -67.75
REMARK 500 ASP A 18 101.42 -56.39
REMARK 500 LYS A 53 -9.88 66.60
REMARK 500 GLN A 74 58.58 -63.04
REMARK 500 ARG A 92 -78.35 -69.71
REMARK 500 CYS A 103 -70.35 -54.06
REMARK 500 SER A 145 114.52 -164.35
REMARK 500 HIS A 159 72.07 64.53
REMARK 500 CYS A 190 100.48 -172.88
REMARK 500 ALA A 196 27.96 -148.59
REMARK 500 ASN A 217 20.48 -78.10
REMARK 500 HIS A 237 19.29 57.55
REMARK 500 HIS A 247 12.38 -68.93
REMARK 500 LEU A 255 -86.25 -63.26
REMARK 500 GLN A 257 35.29 -77.44
REMARK 500 TYR A 258 -34.81 -142.63
REMARK 500 PRO A 274 91.24 -60.82
REMARK 500 VAL A 277 18.02 49.56
REMARK 500 ASP B 30 117.82 -162.86
REMARK 500 GLN B 51 73.85 -159.11
REMARK 500 GLN B 74 49.02 -63.30
REMARK 500 PHE B 89 -74.51 -79.47
REMARK 500 SER B 93 12.49 54.26
REMARK 500 LEU B 107 -72.86 -62.35
REMARK 500 HIS B 159 78.10 65.73
REMARK 500 ASN B 184 3.93 -65.67
REMARK 500 CYS B 186 64.36 60.05
REMARK 500 GLN B 223 171.74 -59.50
REMARK 500 HIS B 247 28.39 -75.88
REMARK 500 GLN B 257 23.27 -67.80
REMARK 500 PRO B 272 -159.63 -82.23
REMARK 500 PRO B 274 80.65 -56.21
REMARK 500 ASP B 327 -18.88 -141.45
REMARK 500 LEU B 339 -72.36 -75.47
REMARK 500 TYR B 340 83.27 -64.39
REMARK 500 SER C 49 -57.91 -120.24
REMARK 500 ASP C 168 26.35 -78.31
REMARK 500 LYS C 186 54.54 -114.19
REMARK 500 MET C 196 2.33 -62.90
REMARK 500 HIS C 198 -31.69 -146.77
REMARK 500 ASN C 202 -1.41 71.72
REMARK 500 SER C 211 93.17 -161.54
REMARK 500 ASP C 255 75.99 -66.02
REMARK 500 PRO C 321 78.69 -61.37
REMARK 500 TYR C 322 -70.05 -65.94
REMARK 500 GLU C 341 68.25 -66.15
REMARK 500 ASP C 361 15.10 -68.85
REMARK 500 TYR C 386 -161.10 -120.87
REMARK 500 SER D 49 -27.50 -141.20
REMARK 500 MET D 169 3.75 -68.25
REMARK 500
REMARK 500 THIS ENTRY HAS 260 RAMACHANDRAN OUTLIERS.
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS
REMARK 500
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH
REMARK 500 CIS AND TRANS CONFORMATION. CIS BONDS, IF ANY, ARE LISTED
REMARK 500 ON CISPEP RECORDS. TRANS IS DEFINED AS 180 +/- 30 AND
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.
REMARK 500 MODEL OMEGA
REMARK 500 THR E 340 PRO E 341 144.21
REMARK 500 ARG E 344 LEU E 345 -149.32
REMARK 500 ARG F 344 LEU F 345 -134.04
REMARK 500
REMARK 500 REMARK: NULL
REMARK 800
REMARK 800 SITE
REMARK 800 SITE_IDENTIFIER: AC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue PO4 A 401
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue PO4 B 401
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue PO4 C 401
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue PO4 D 401
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC5
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue PO4 E 501
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC6
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue PO4 E 502
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC7
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue PO4 F 501
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC8
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue PO4 F 502
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC9
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue PO4 G 501
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue PO4 H 501
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue PO4 I 701
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue PO4 J 701
DBREF 6JLZ A 1 341 UNP Q9USP0 EI2BA_SCHPO 1 341
DBREF 6JLZ B 1 341 UNP Q9USP0 EI2BA_SCHPO 1 341
DBREF 6JLZ C 1 393 UNP Q9UT76 EI2BB_SCHPO 1 393
DBREF 6JLZ D 1 393 UNP Q9UT76 EI2BB_SCHPO 1 393
DBREF 6JLZ E 1 458 UNP P56288 EI2BG_SCHPO 1 458
DBREF 6JLZ F 1 458 UNP P56288 EI2BG_SCHPO 1 458
DBREF 6JLZ G 1 467 UNP Q09924 EI2BD_SCHPO 1 467
DBREF 6JLZ H 1 467 UNP Q09924 EI2BD_SCHPO 1 467
DBREF 6JLZ I 1 678 UNP P56287 EI2BE_SCHPO 1 678
DBREF 6JLZ J 1 678 UNP P56287 EI2BE_SCHPO 1 678
DBREF 6JLZ L 0 303 UNP P20459 IF2A_YEAST 1 304
DBREF 6JLZ M 0 303 UNP P20459 IF2A_YEAST 1 304
SEQADV 6JLZ GLY C -5 UNP Q9UT76 EXPRESSION TAG
SEQADV 6JLZ PRO C -4 UNP Q9UT76 EXPRESSION TAG
SEQADV 6JLZ ILE C -3 UNP Q9UT76 EXPRESSION TAG
SEQADV 6JLZ SER C -2 UNP Q9UT76 EXPRESSION TAG
SEQADV 6JLZ GLU C -1 UNP Q9UT76 EXPRESSION TAG
SEQADV 6JLZ PHE C 0 UNP Q9UT76 EXPRESSION TAG
SEQADV 6JLZ GLY D -5 UNP Q9UT76 EXPRESSION TAG
SEQADV 6JLZ PRO D -4 UNP Q9UT76 EXPRESSION TAG
SEQADV 6JLZ ILE D -3 UNP Q9UT76 EXPRESSION TAG
SEQADV 6JLZ SER D -2 UNP Q9UT76 EXPRESSION TAG
SEQADV 6JLZ GLU D -1 UNP Q9UT76 EXPRESSION TAG
SEQADV 6JLZ PHE D 0 UNP Q9UT76 EXPRESSION TAG
SEQADV 6JLZ TYR E 157 UNP P56288 ILE 157 CONFLICT
SEQADV 6JLZ THR E 158 UNP P56288 TYR 158 CONFLICT
SEQADV 6JLZ VAL E 159 UNP P56288 GLY 159 CONFLICT
SEQADV 6JLZ TYR F 157 UNP P56288 ILE 157 CONFLICT
SEQADV 6JLZ THR F 158 UNP P56288 TYR 158 CONFLICT
SEQADV 6JLZ VAL F 159 UNP P56288 GLY 159 CONFLICT
SEQRES 1 A 341 MET VAL GLU SER ASP SER SER GLY ILE VAL ARG HIS SER
SEQRES 2 A 341 GLN GLY GLU PHE ASP ILE VAL GLN VAL TYR LYS LYS PHE
SEQRES 3 A 341 LEU GLN ASP ASP PRO GLU ILE THR MET PRO VAL ALA ALA
SEQRES 4 A 341 ILE GLU ALA LEU VAL GLN LEU LEU SER ARG SER GLN ALA
SEQRES 5 A 341 LYS THR ILE SER GLU PHE MET ASP ILE LEU GLN ASN GLY
SEQRES 6 A 341 SER ASN THR LEU LYS GLU GLY VAL GLN ASN ASN ILE SER
SEQRES 7 A 341 LEU SER ALA GLY CYS ASP ILE PHE GLN ARG PHE VAL THR
SEQRES 8 A 341 ARG SER LEU HIS ASP VAL GLY ASP PHE GLU GLN CYS LYS
SEQRES 9 A 341 ARG HIS LEU VAL GLU ASN GLY LYS LEU PHE ILE GLN ARG
SEQRES 10 A 341 ALA ARG ALA CYS ARG GLN ARG ILE ALA HIS LEU GLY TYR
SEQRES 11 A 341 PRO LEU ILE ARG ASP GLY SER VAL ILE LEU THR HIS GLY
SEQRES 12 A 341 PHE SER ARG GLY VAL ALA ALA VAL LEU LEU ALA ALA ALA
SEQRES 13 A 341 LYS ARG HIS VAL ARG PHE LYS VAL PHE VAL THR GLU SER
SEQRES 14 A 341 ARG PRO SER GLY SER GLY CYS LEU MET THR ARG THR LEU
SEQRES 15 A 341 LYS ASN ALA CYS ILE PRO THR CYS MET VAL LEU ASP SER
SEQRES 16 A 341 ALA VAL SER PHE THR MET ASN ARG VAL ASP LEU VAL LEU
SEQRES 17 A 341 VAL GLY ALA GLU GLY VAL VAL GLU ASN GLY GLY LEU ILE
SEQRES 18 A 341 ASN GLN ILE GLY THR PHE GLN LEU ALA VAL PHE ALA LYS
SEQRES 19 A 341 HIS ALA HIS LYS PRO PHE TYR ALA VAL ALA GLU SER HIS
SEQRES 20 A 341 LYS PHE VAL ARG MET PHE PRO LEU SER GLN TYR ASP ILE
SEQRES 21 A 341 PRO PHE SER ARG PRO ILE LEU GLU PHE ASP ASP PRO SER
SEQRES 22 A 341 PRO GLU THR VAL HIS PRO GLU PRO GLU PRO ILE PRO THR
SEQRES 23 A 341 PRO SER ASP ALA ILE HIS ASN GLU LEU ILE MET ASN GLU
SEQRES 24 A 341 GLU GLN ILE ARG ASN ASN PRO THR LEU ASP VAL THR PRO
SEQRES 25 A 341 PRO GLU PHE VAL SER GLY LEU ILE THR ASP LEU GLY ILE
SEQRES 26 A 341 ILE ASP SER LYS SER GLY VAL SER GLU GLU LEU ILE LYS
SEQRES 27 A 341 LEU TYR LEU
SEQRES 1 B 341 MET VAL GLU SER ASP SER SER GLY ILE VAL ARG HIS SER
SEQRES 2 B 341 GLN GLY GLU PHE ASP ILE VAL GLN VAL TYR LYS LYS PHE
SEQRES 3 B 341 LEU GLN ASP ASP PRO GLU ILE THR MET PRO VAL ALA ALA
SEQRES 4 B 341 ILE GLU ALA LEU VAL GLN LEU LEU SER ARG SER GLN ALA
SEQRES 5 B 341 LYS THR ILE SER GLU PHE MET ASP ILE LEU GLN ASN GLY
SEQRES 6 B 341 SER ASN THR LEU LYS GLU GLY VAL GLN ASN ASN ILE SER
SEQRES 7 B 341 LEU SER ALA GLY CYS ASP ILE PHE GLN ARG PHE VAL THR
SEQRES 8 B 341 ARG SER LEU HIS ASP VAL GLY ASP PHE GLU GLN CYS LYS
SEQRES 9 B 341 ARG HIS LEU VAL GLU ASN GLY LYS LEU PHE ILE GLN ARG
SEQRES 10 B 341 ALA ARG ALA CYS ARG GLN ARG ILE ALA HIS LEU GLY TYR
SEQRES 11 B 341 PRO LEU ILE ARG ASP GLY SER VAL ILE LEU THR HIS GLY
SEQRES 12 B 341 PHE SER ARG GLY VAL ALA ALA VAL LEU LEU ALA ALA ALA
SEQRES 13 B 341 LYS ARG HIS VAL ARG PHE LYS VAL PHE VAL THR GLU SER
SEQRES 14 B 341 ARG PRO SER GLY SER GLY CYS LEU MET THR ARG THR LEU
SEQRES 15 B 341 LYS ASN ALA CYS ILE PRO THR CYS MET VAL LEU ASP SER
SEQRES 16 B 341 ALA VAL SER PHE THR MET ASN ARG VAL ASP LEU VAL LEU
SEQRES 17 B 341 VAL GLY ALA GLU GLY VAL VAL GLU ASN GLY GLY LEU ILE
SEQRES 18 B 341 ASN GLN ILE GLY THR PHE GLN LEU ALA VAL PHE ALA LYS
SEQRES 19 B 341 HIS ALA HIS LYS PRO PHE TYR ALA VAL ALA GLU SER HIS
SEQRES 20 B 341 LYS PHE VAL ARG MET PHE PRO LEU SER GLN TYR ASP ILE
SEQRES 21 B 341 PRO PHE SER ARG PRO ILE LEU GLU PHE ASP ASP PRO SER
SEQRES 22 B 341 PRO GLU THR VAL HIS PRO GLU PRO GLU PRO ILE PRO THR
SEQRES 23 B 341 PRO SER ASP ALA ILE HIS ASN GLU LEU ILE MET ASN GLU
SEQRES 24 B 341 GLU GLN ILE ARG ASN ASN PRO THR LEU ASP VAL THR PRO
SEQRES 25 B 341 PRO GLU PHE VAL SER GLY LEU ILE THR ASP LEU GLY ILE
SEQRES 26 B 341 ILE ASP SER LYS SER GLY VAL SER GLU GLU LEU ILE LYS
SEQRES 27 B 341 LEU TYR LEU
SEQRES 1 C 399 GLY PRO ILE SER GLU PHE MET SER THR ILE ASN VAL GLU
SEQRES 2 C 399 HIS THR TYR PRO ALA VAL SER SER LEU ILE ALA ASP LEU
SEQRES 3 C 399 LYS SER ARG LYS VAL GLN GLY PRO PHE ALA VAL ALA VAL
SEQRES 4 C 399 GLU THR ALA LEU VAL MET ARG GLN VAL ILE SER GLN THR
SEQRES 5 C 399 ARG TRP SER THR VAL ASP GLN LEU ILE ASP THR VAL ARG
SEQRES 6 C 399 ALA VAL GLY SER THR LEU VAL LYS ALA GLN PRO THR GLU
SEQRES 7 C 399 PHE SER CYS GLY ASN ILE ILE ARG ARG ILE LEU ARG LEU
SEQRES 8 C 399 ILE ARG GLU GLU TYR GLN GLU LEU LEU LYS THR ALA ASP
SEQRES 9 C 399 GLU ASN GLU LYS LEU ILE VAL SER SER SER ASN SER SER
SEQRES 10 C 399 SER PRO SER GLN LYS ARG ASP ILE PRO SER ASN GLU LYS
SEQRES 11 C 399 LEU VAL GLN SER HIS GLU PRO VAL SER VAL GLN MET TYR
SEQRES 12 C 399 SER SER MET LEU ASN LEU LEU GLY ARG PRO THR LEU GLU
SEQRES 13 C 399 SER PRO THR HIS SER LYS THR VAL GLY ASP SER ARG VAL
SEQRES 14 C 399 THR GLY GLY MET ASP MET ARG ALA VAL ILE ILE SER GLY
SEQRES 15 C 399 ILE GLN ASP VAL ILE ASP GLU LEU ASP LYS ILE ASN THR
SEQRES 16 C 399 ASP ILE GLU VAL GLN SER MET ASP HIS LEU HIS SER ASN
SEQRES 17 C 399 GLU ILE ILE LEU THR GLN GLY CYS SER LYS THR VAL GLU
SEQRES 18 C 399 ALA PHE LEU ARG PHE ALA ALA LYS LYS ARG LYS PHE SER
SEQRES 19 C 399 VAL ILE VAL ALA GLU GLY PHE PRO ASN ASN GLN LYS GLY
SEQRES 20 C 399 SER HIS ALA MET ALA LYS ARG LEU ALA GLN ALA GLY ILE
SEQRES 21 C 399 ASP THR THR VAL ILE SER ASP ALA THR ILE PHE ALA ILE
SEQRES 22 C 399 MET SER ARG VAL ASN LYS VAL ILE LEU GLY THR HIS ALA
SEQRES 23 C 399 ILE LEU GLY ASN GLY GLY LEU VAL THR TYR SER GLY ALA
SEQRES 24 C 399 GLN LEU VAL ALA GLN ALA ALA ARG HIS HIS ALA THR PRO
SEQRES 25 C 399 VAL VAL VAL CYS SER GLY ILE TYR LYS LEU SER PRO VAL
SEQRES 26 C 399 TYR PRO TYR ASP LEU GLU SER ILE ILE GLN LEU SER SER
SEQRES 27 C 399 PRO ASP LYS ILE MET SER PHE ASN GLU GLY ASP LEU ILE
SEQRES 28 C 399 SER ARG ALA GLU ILE LEU ASN PRO TYR TYR ASP TYR ILE
SEQRES 29 C 399 PRO PRO ASP LEU VAL ASP LEU PHE ILE THR ASN LEU GLY
SEQRES 30 C 399 GLY TYR PRO PRO SER TYR LEU TYR ARG ILE MET ASN ASP
SEQRES 31 C 399 THR TYR ASP ALA SER ASP THR ILE LEU
SEQRES 1 D 399 GLY PRO ILE SER GLU PHE MET SER THR ILE ASN VAL GLU
SEQRES 2 D 399 HIS THR TYR PRO ALA VAL SER SER LEU ILE ALA ASP LEU
SEQRES 3 D 399 LYS SER ARG LYS VAL GLN GLY PRO PHE ALA VAL ALA VAL
SEQRES 4 D 399 GLU THR ALA LEU VAL MET ARG GLN VAL ILE SER GLN THR
SEQRES 5 D 399 ARG TRP SER THR VAL ASP GLN LEU ILE ASP THR VAL ARG
SEQRES 6 D 399 ALA VAL GLY SER THR LEU VAL LYS ALA GLN PRO THR GLU
SEQRES 7 D 399 PHE SER CYS GLY ASN ILE ILE ARG ARG ILE LEU ARG LEU
SEQRES 8 D 399 ILE ARG GLU GLU TYR GLN GLU LEU LEU LYS THR ALA ASP
SEQRES 9 D 399 GLU ASN GLU LYS LEU ILE VAL SER SER SER ASN SER SER
SEQRES 10 D 399 SER PRO SER GLN LYS ARG ASP ILE PRO SER ASN GLU LYS
SEQRES 11 D 399 LEU VAL GLN SER HIS GLU PRO VAL SER VAL GLN MET TYR
SEQRES 12 D 399 SER SER MET LEU ASN LEU LEU GLY ARG PRO THR LEU GLU
SEQRES 13 D 399 SER PRO THR HIS SER LYS THR VAL GLY ASP SER ARG VAL
SEQRES 14 D 399 THR GLY GLY MET ASP MET ARG ALA VAL ILE ILE SER GLY
SEQRES 15 D 399 ILE GLN ASP VAL ILE ASP GLU LEU ASP LYS ILE ASN THR
SEQRES 16 D 399 ASP ILE GLU VAL GLN SER MET ASP HIS LEU HIS SER ASN
SEQRES 17 D 399 GLU ILE ILE LEU THR GLN GLY CYS SER LYS THR VAL GLU
SEQRES 18 D 399 ALA PHE LEU ARG PHE ALA ALA LYS LYS ARG LYS PHE SER
SEQRES 19 D 399 VAL ILE VAL ALA GLU GLY PHE PRO ASN ASN GLN LYS GLY
SEQRES 20 D 399 SER HIS ALA MET ALA LYS ARG LEU ALA GLN ALA GLY ILE
SEQRES 21 D 399 ASP THR THR VAL ILE SER ASP ALA THR ILE PHE ALA ILE
SEQRES 22 D 399 MET SER ARG VAL ASN LYS VAL ILE LEU GLY THR HIS ALA
SEQRES 23 D 399 ILE LEU GLY ASN GLY GLY LEU VAL THR TYR SER GLY ALA
SEQRES 24 D 399 GLN LEU VAL ALA GLN ALA ALA ARG HIS HIS ALA THR PRO
SEQRES 25 D 399 VAL VAL VAL CYS SER GLY ILE TYR LYS LEU SER PRO VAL
SEQRES 26 D 399 TYR PRO TYR ASP LEU GLU SER ILE ILE GLN LEU SER SER
SEQRES 27 D 399 PRO ASP LYS ILE MET SER PHE ASN GLU GLY ASP LEU ILE
SEQRES 28 D 399 SER ARG ALA GLU ILE LEU ASN PRO TYR TYR ASP TYR ILE
SEQRES 29 D 399 PRO PRO ASP LEU VAL ASP LEU PHE ILE THR ASN LEU GLY
SEQRES 30 D 399 GLY TYR PRO PRO SER TYR LEU TYR ARG ILE MET ASN ASP
SEQRES 31 D 399 THR TYR ASP ALA SER ASP THR ILE LEU
SEQRES 1 E 458 MET SER LEU TYR GLU HIS ALA ALA LEU PRO LEU ALA SER
SEQRES 2 E 458 SER PRO SER ILE LEU GLY PRO ILE SER GLY GLY ARG ASN
SEQRES 3 E 458 ARG GLY ASN ILE GLN LEU GLN SER ILE PRO ILE GLU PHE
SEQRES 4 E 458 GLN ALA VAL VAL PHE ALA GLY PHE GLY ASN SER LEU TYR
SEQRES 5 E 458 PRO LEU THR GLY SER ASP ALA LEU PRO LYS ALA LEU LEU
SEQRES 6 E 458 PRO ILE GLY ASN LYS PRO MET LEU HIS TYR PRO LEU TYR
SEQRES 7 E 458 TRP LEU GLU ALA ALA GLY PHE THR SER ALA ILE LEU ILE
SEQRES 8 E 458 CYS MET GLU GLU ALA GLU ALA HIS ILE ASN ALA TRP LEU
SEQRES 9 E 458 ARG SER GLY TYR GLU GLY HIS MET ARG ILE HIS VAL GLU
SEQRES 10 E 458 ALA PRO THR ILE LEU ASP ASP SER LYS SER SER ALA ASP
SEQRES 11 E 458 ALA LEU ARG ALA VAL SER HIS LEU ILE LYS ASN ASP PHE
SEQRES 12 E 458 VAL CYS LEU SER CYS ASP SER ILE VAL GLY LEU PRO PRO
SEQRES 13 E 458 TYR THR VAL LEU ASP LYS PHE ARG LEU ASP ASN PRO SER
SEQRES 14 E 458 ALA LEU ALA VAL TYR SER PRO VAL LEU LYS TYR GLU HIS
SEQRES 15 E 458 ILE THR SER GLN SER LYS GLU ILE ASP ALA LYS GLN LEU
SEQRES 16 E 458 ILE GLY ILE GLU GLU LYS THR SER ARG LEU LEU TYR ALA
SEQRES 17 E 458 LYS SER SER ALA ASP VAL GLY SER ASP PHE THR PHE ARG
SEQRES 18 E 458 MET SER LEU LEU TRP LYS HIS PRO ARG VAL THR LEU ASN
SEQRES 19 E 458 THR ASN LEU SER ASP ALA HIS ILE PHE VAL PHE LYS HIS
SEQRES 20 E 458 TRP VAL ILE ASP LEU ILE ARG GLU LYS GLU SER ILE SER
SEQRES 21 E 458 SER ILE ARG GLY ASP LEU ILE PRO TYR LEU VAL LYS CYS
SEQRES 22 E 458 GLN TYR GLN LYS SER PHE THR VAL ARG GLU ASN ILE GLN
SEQRES 23 E 458 ARG PHE LEU SER SER PRO ASN ASN ILE ASP ASN TYR ASP
SEQRES 24 E 458 GLY GLY LEU SER SER GLN GLU ILE LYS ILE ASN ALA LEU
SEQRES 25 E 458 ILE ALA LYS ASP GLY ILE ILE CYS SER ARG ALA ASN ASN
SEQRES 26 E 458 LEU PRO ASN TYR PHE GLU LEU ASN LYS CYS ILE ALA LYS
SEQRES 27 E 458 LEU THR PRO GLU GLN ARG LEU VAL ASP VAL THR VAL SER
SEQRES 28 E 458 GLU ARG ALA LEU VAL GLY ALA ASP CYS MET VAL ASN GLU
SEQRES 29 E 458 GLY THR THR ILE LYS ASP ASN SER ASN ILE LYS LYS SER
SEQRES 30 E 458 ILE ILE GLY LYS ASN CYS VAL ILE GLY LYS GLY VAL VAL
SEQRES 31 E 458 VAL SER ASN SER ILE LEU MET ASP ASN ILE VAL VAL GLU
SEQRES 32 E 458 ASP GLY VAL ARG LEU GLU SER CYS ILE VAL ALA SER GLY
SEQRES 33 E 458 ALA GLN ILE GLY ALA LYS SER LYS LEU ARG GLU CYS GLU
SEQRES 34 E 458 ILE GLY VAL ASP HIS ARG VAL GLU ALA GLY ARG ILE ALA
SEQRES 35 E 458 ARG GLY GLU ARG LEU VAL ASP MET GLU LYS ILE GLU THR
SEQRES 36 E 458 ASP MET ASP
SEQRES 1 F 458 MET SER LEU TYR GLU HIS ALA ALA LEU PRO LEU ALA SER
SEQRES 2 F 458 SER PRO SER ILE LEU GLY PRO ILE SER GLY GLY ARG ASN
SEQRES 3 F 458 ARG GLY ASN ILE GLN LEU GLN SER ILE PRO ILE GLU PHE
SEQRES 4 F 458 GLN ALA VAL VAL PHE ALA GLY PHE GLY ASN SER LEU TYR
SEQRES 5 F 458 PRO LEU THR GLY SER ASP ALA LEU PRO LYS ALA LEU LEU
SEQRES 6 F 458 PRO ILE GLY ASN LYS PRO MET LEU HIS TYR PRO LEU TYR
SEQRES 7 F 458 TRP LEU GLU ALA ALA GLY PHE THR SER ALA ILE LEU ILE
SEQRES 8 F 458 CYS MET GLU GLU ALA GLU ALA HIS ILE ASN ALA TRP LEU
SEQRES 9 F 458 ARG SER GLY TYR GLU GLY HIS MET ARG ILE HIS VAL GLU
SEQRES 10 F 458 ALA PRO THR ILE LEU ASP ASP SER LYS SER SER ALA ASP
SEQRES 11 F 458 ALA LEU ARG ALA VAL SER HIS LEU ILE LYS ASN ASP PHE
SEQRES 12 F 458 VAL CYS LEU SER CYS ASP SER ILE VAL GLY LEU PRO PRO
SEQRES 13 F 458 TYR THR VAL LEU ASP LYS PHE ARG LEU ASP ASN PRO SER
SEQRES 14 F 458 ALA LEU ALA VAL TYR SER PRO VAL LEU LYS TYR GLU HIS
SEQRES 15 F 458 ILE THR SER GLN SER LYS GLU ILE ASP ALA LYS GLN LEU
SEQRES 16 F 458 ILE GLY ILE GLU GLU LYS THR SER ARG LEU LEU TYR ALA
SEQRES 17 F 458 LYS SER SER ALA ASP VAL GLY SER ASP PHE THR PHE ARG
SEQRES 18 F 458 MET SER LEU LEU TRP LYS HIS PRO ARG VAL THR LEU ASN
SEQRES 19 F 458 THR ASN LEU SER ASP ALA HIS ILE PHE VAL PHE LYS HIS
SEQRES 20 F 458 TRP VAL ILE ASP LEU ILE ARG GLU LYS GLU SER ILE SER
SEQRES 21 F 458 SER ILE ARG GLY ASP LEU ILE PRO TYR LEU VAL LYS CYS
SEQRES 22 F 458 GLN TYR GLN LYS SER PHE THR VAL ARG GLU ASN ILE GLN
SEQRES 23 F 458 ARG PHE LEU SER SER PRO ASN ASN ILE ASP ASN TYR ASP
SEQRES 24 F 458 GLY GLY LEU SER SER GLN GLU ILE LYS ILE ASN ALA LEU
SEQRES 25 F 458 ILE ALA LYS ASP GLY ILE ILE CYS SER ARG ALA ASN ASN
SEQRES 26 F 458 LEU PRO ASN TYR PHE GLU LEU ASN LYS CYS ILE ALA LYS
SEQRES 27 F 458 LEU THR PRO GLU GLN ARG LEU VAL ASP VAL THR VAL SER
SEQRES 28 F 458 GLU ARG ALA LEU VAL GLY ALA ASP CYS MET VAL ASN GLU
SEQRES 29 F 458 GLY THR THR ILE LYS ASP ASN SER ASN ILE LYS LYS SER
SEQRES 30 F 458 ILE ILE GLY LYS ASN CYS VAL ILE GLY LYS GLY VAL VAL
SEQRES 31 F 458 VAL SER ASN SER ILE LEU MET ASP ASN ILE VAL VAL GLU
SEQRES 32 F 458 ASP GLY VAL ARG LEU GLU SER CYS ILE VAL ALA SER GLY
SEQRES 33 F 458 ALA GLN ILE GLY ALA LYS SER LYS LEU ARG GLU CYS GLU
SEQRES 34 F 458 ILE GLY VAL ASP HIS ARG VAL GLU ALA GLY ARG ILE ALA
SEQRES 35 F 458 ARG GLY GLU ARG LEU VAL ASP MET GLU LYS ILE GLU THR
SEQRES 36 F 458 ASP MET ASP
SEQRES 1 G 467 MET GLY PHE SER ALA GLU GLN ALA LYS LYS ASP GLY LYS
SEQRES 2 G 467 ASP GLN SER PRO VAL SER GLU SER SER SER VAL GLY GLY
SEQRES 3 G 467 THR SER PRO ALA THR ALA SER SER VAL VAL SER PRO ASN
SEQRES 4 G 467 GLU PRO LYS LEU SER GLY LYS GLU ALA LYS ALA LEU LYS
SEQRES 5 G 467 LYS ALA ARG LYS GLN ALA SER ARG ARG ALA LYS ALA GLU
SEQRES 6 G 467 ALA ALA ALA ALA ASN ASN PRO PRO GLY VAL SER GLU GLU
SEQRES 7 G 467 LYS LYS VAL ALA ILE PRO ASN LYS ASN SER ASN GLN GLN
SEQRES 8 G 467 LYS LYS ALA SER LYS GLN ASN PRO GLN ASN SER PRO GLU
SEQRES 9 G 467 THR ASP ALA ASN LEU GLN GLU LYS LYS ILE PHE GLU GLU
SEQRES 10 G 467 LYS GLN VAL SER ILE PHE SER HIS LEU ASP TRP ARG ARG
SEQRES 11 G 467 ARG ARG THR THR GLU ASN ILE PRO LYS ASP ILE HIS PRO
SEQRES 12 G 467 ALA VAL ILE ARG LEU GLY LEU LYS LEU ALA ASN TYR LYS
SEQRES 13 G 467 ILE PHE GLY SER ASN GLN ARG CYS ILE ASP LEU LEU LYS
SEQRES 14 G 467 THR PHE LYS ILE VAL ILE GLN ASP TYR GLN THR PRO TYR
SEQRES 15 G 467 GLY THR THR LEU SER ARG HIS LEU THR THR HIS ILE ASN
SEQRES 16 G 467 SER GLN ILE ALA TYR LEU VAL SER THR ARG PRO LEU SER
SEQRES 17 G 467 ILE SER MET GLY ASN ALA ILE ARG PHE LEU LYS LEU GLU
SEQRES 18 G 467 ILE SER VAL LEU ASP ILE ASP LEU THR ASP ASP GLU GLY
SEQRES 19 G 467 LYS GLU LEU LEU LEU GLU LYS ILE ASP SER TYR ILE ARG
SEQRES 20 G 467 ASP ARG ILE ILE ILE ALA GLY GLN VAL ILE VAL GLN ALA
SEQRES 21 G 467 ALA THR GLU LYS ILE GLN ASP GLY ASP VAL ILE LEU THR
SEQRES 22 G 467 TYR LEU HIS SER SER THR VAL ASN ASP VAL LEU ILE HIS
SEQRES 23 G 467 ALA LYS ASN VAL GLY LYS LYS PHE ARG VAL VAL VAL VAL
SEQRES 24 G 467 ASP SER ARG PRO GLU PHE GLU GLY ARG VAL CYS LEU LYS
SEQRES 25 G 467 LEU LEU THR GLU HIS GLY ILE GLU CYS THR TYR VAL MET
SEQRES 26 G 467 ILE SER ALA LEU SER TYR ILE MET GLN GLU VAL THR LYS
SEQRES 27 G 467 ILE PHE LEU GLY GLY HIS ALA MET LEU SER ASN GLY ALA
SEQRES 28 G 467 LEU TYR SER ARG ALA GLY THR SER LEU ILE SER LEU LEU
SEQRES 29 G 467 GLY HIS GLU SER ASN VAL PRO VAL ILE ALA CYS CYS GLU
SEQRES 30 G 467 SER TYR LYS PHE THR GLU ARG ILE GLN LEU ASP SER LEU
SEQRES 31 G 467 VAL TYR ASN GLU LEU ALA PRO GLY ASP GLN LEU VAL ASN
SEQRES 32 G 467 MET GLY VAL ASP ASP PHE GLU GLU LYS PRO GLY VAL LEU
SEQRES 33 G 467 ALA ASN TRP LYS SER VAL LYS ASN LEU LYS LEU LEU SER
SEQRES 34 G 467 LEU LYS TYR ASP VAL THR PRO PRO ARG LEU ILE THR VAL
SEQRES 35 G 467 CYS VAL CYS GLU MET GLY LEU LEU PRO SER THR SER VAL
SEQRES 36 G 467 PRO ALA ILE ILE ASN GLU PHE LYS GLN VAL TYR ALA
SEQRES 1 H 467 MET GLY PHE SER ALA GLU GLN ALA LYS LYS ASP GLY LYS
SEQRES 2 H 467 ASP GLN SER PRO VAL SER GLU SER SER SER VAL GLY GLY
SEQRES 3 H 467 THR SER PRO ALA THR ALA SER SER VAL VAL SER PRO ASN
SEQRES 4 H 467 GLU PRO LYS LEU SER GLY LYS GLU ALA LYS ALA LEU LYS
SEQRES 5 H 467 LYS ALA ARG LYS GLN ALA SER ARG ARG ALA LYS ALA GLU
SEQRES 6 H 467 ALA ALA ALA ALA ASN ASN PRO PRO GLY VAL SER GLU GLU
SEQRES 7 H 467 LYS LYS VAL ALA ILE PRO ASN LYS ASN SER ASN GLN GLN
SEQRES 8 H 467 LYS LYS ALA SER LYS GLN ASN PRO GLN ASN SER PRO GLU
SEQRES 9 H 467 THR ASP ALA ASN LEU GLN GLU LYS LYS ILE PHE GLU GLU
SEQRES 10 H 467 LYS GLN VAL SER ILE PHE SER HIS LEU ASP TRP ARG ARG
SEQRES 11 H 467 ARG ARG THR THR GLU ASN ILE PRO LYS ASP ILE HIS PRO
SEQRES 12 H 467 ALA VAL ILE ARG LEU GLY LEU LYS LEU ALA ASN TYR LYS
SEQRES 13 H 467 ILE PHE GLY SER ASN GLN ARG CYS ILE ASP LEU LEU LYS
SEQRES 14 H 467 THR PHE LYS ILE VAL ILE GLN ASP TYR GLN THR PRO TYR
SEQRES 15 H 467 GLY THR THR LEU SER ARG HIS LEU THR THR HIS ILE ASN
SEQRES 16 H 467 SER GLN ILE ALA TYR LEU VAL SER THR ARG PRO LEU SER
SEQRES 17 H 467 ILE SER MET GLY ASN ALA ILE ARG PHE LEU LYS LEU GLU
SEQRES 18 H 467 ILE SER VAL LEU ASP ILE ASP LEU THR ASP ASP GLU GLY
SEQRES 19 H 467 LYS GLU LEU LEU LEU GLU LYS ILE ASP SER TYR ILE ARG
SEQRES 20 H 467 ASP ARG ILE ILE ILE ALA GLY GLN VAL ILE VAL GLN ALA
SEQRES 21 H 467 ALA THR GLU LYS ILE GLN ASP GLY ASP VAL ILE LEU THR
SEQRES 22 H 467 TYR LEU HIS SER SER THR VAL ASN ASP VAL LEU ILE HIS
SEQRES 23 H 467 ALA LYS ASN VAL GLY LYS LYS PHE ARG VAL VAL VAL VAL
SEQRES 24 H 467 ASP SER ARG PRO GLU PHE GLU GLY ARG VAL CYS LEU LYS
SEQRES 25 H 467 LEU LEU THR GLU HIS GLY ILE GLU CYS THR TYR VAL MET
SEQRES 26 H 467 ILE SER ALA LEU SER TYR ILE MET GLN GLU VAL THR LYS
SEQRES 27 H 467 ILE PHE LEU GLY GLY HIS ALA MET LEU SER ASN GLY ALA
SEQRES 28 H 467 LEU TYR SER ARG ALA GLY THR SER LEU ILE SER LEU LEU
SEQRES 29 H 467 GLY HIS GLU SER ASN VAL PRO VAL ILE ALA CYS CYS GLU
SEQRES 30 H 467 SER TYR LYS PHE THR GLU ARG ILE GLN LEU ASP SER LEU
SEQRES 31 H 467 VAL TYR ASN GLU LEU ALA PRO GLY ASP GLN LEU VAL ASN
SEQRES 32 H 467 MET GLY VAL ASP ASP PHE GLU GLU LYS PRO GLY VAL LEU
SEQRES 33 H 467 ALA ASN TRP LYS SER VAL LYS ASN LEU LYS LEU LEU SER
SEQRES 34 H 467 LEU LYS TYR ASP VAL THR PRO PRO ARG LEU ILE THR VAL
SEQRES 35 H 467 CYS VAL CYS GLU MET GLY LEU LEU PRO SER THR SER VAL
SEQRES 36 H 467 PRO ALA ILE ILE ASN GLU PHE LYS GLN VAL TYR ALA
SEQRES 1 I 678 MET PRO PRO SER LYS GLY LEU ASN GLY LYS LEU GLU LYS
SEQRES 2 I 678 PRO LYS HIS ALA LEU GLN ALA ILE VAL LEU SER ASP SER
SEQRES 3 I 678 TYR ASN TYR ARG PHE ARG PRO LEU THR LEU ASP LYS PRO
SEQRES 4 I 678 ARG CYS LEU LEU PRO LEU ALA ASN THR PRO LEU ILE GLU
SEQRES 5 I 678 TYR THR PHE GLU PHE LEU ALA LEU ALA GLY VAL GLN GLU
SEQRES 6 I 678 VAL TYR VAL PHE CYS CYS ALA HIS ALA GLY GLN ILE ARG
SEQRES 7 I 678 GLU TYR ILE GLU LYS SER LYS TRP ASN LEU PRO SER SER
SEQRES 8 I 678 PRO PHE SER VAL ASN THR ILE VAL SER ARG GLU SER LEU
SEQRES 9 I 678 SER VAL GLY ASP ALA LEU ARG GLU LEU ASP SER LYS GLN
SEQRES 10 I 678 LEU ILE THR SER ASP PHE ILE LEU VAL SER GLY ASP VAL
SEQRES 11 I 678 VAL SER ASN VAL PRO LEU ASN GLU VAL LEU LYS GLU HIS
SEQRES 12 I 678 ARG LYS ARG ARG GLU ASP ASP LYS ASN ALA ILE MET THR
SEQRES 13 I 678 MET VAL VAL ARG GLU ALA SER PRO PHE HIS ARG THR ARG
SEQRES 14 I 678 ALA ARG THR GLU SER SER VAL PHE VAL ILE ASP LYS LYS
SEQRES 15 I 678 THR SER GLN CYS VAL HIS TYR GLN ALA ASN GLU ARG GLY
SEQRES 16 I 678 LYS HIS TYR VAL SER MET ASP PRO GLU ILE PHE ASN GLU
SEQRES 17 I 678 HIS GLU GLU LEU GLU VAL ARG ASN ASP LEU ILE ASP CYS
SEQRES 18 I 678 GLN ILE ASP ILE CYS SER ASN ASP VAL PRO ALA LEU PHE
SEQRES 19 I 678 THR GLU ASN PHE ASP TYR GLN ASP ILE ARG LYS ASP PHE
SEQRES 20 I 678 VAL TYR GLY VAL LEU THR SER ASP LEU LEU GLY LYS LYS
SEQRES 21 I 678 ILE HIS CYS HIS VAL ALA LYS GLU ASN TYR ALA ALA ARG
SEQRES 22 I 678 VAL ARG SER LEU GLN THR TYR ASP ALA ILE SER LYS ASP
SEQRES 23 I 678 VAL LEU SER ARG TRP VAL TYR PRO PHE VAL PRO ASP SER
SEQRES 24 I 678 ASN LEU LEU ASN GLN THR PHE SER TYR GLN ARG HIS GLN
SEQRES 25 I 678 ILE TYR LYS GLU GLU ASP VAL VAL LEU ALA ARG SER CYS
SEQRES 26 I 678 ILE ILE LYS ALA ARG THR LEU ILE GLY ALA TYR THR LYS
SEQRES 27 I 678 VAL GLY ASP ALA SER VAL VAL ALA ASN THR ILE ILE GLY
SEQRES 28 I 678 ARG ASN CYS THR ILE GLY SER ASN CYS SER ILE ASP SER
SEQRES 29 I 678 ALA PHE LEU TRP GLU ASP VAL VAL ILE GLY ASP ASN CYS
SEQRES 30 I 678 ARG ILE GLY LYS ALA ILE LEU ALA ASN SER VAL LYS ILE
SEQRES 31 I 678 GLY ASN ASN CYS SER ILE GLU ASP GLY ALA ILE VAL ALA
SEQRES 32 I 678 ALA GLY VAL VAL ILE GLY ASP ASN THR ILE ILE GLU LYS
SEQRES 33 I 678 ASN LYS ARG LEU THR THR PHE GLU SER HIS SER GLN GLY
SEQRES 34 I 678 THR LEU ASN ASP PRO SER LEU VAL GLY ILE GLY GLY ARG
SEQRES 35 I 678 GLY GLN GLU TYR HIS ALA GLU GLU ASP SER ASP ASP GLU
SEQRES 36 I 678 GLY GLU PHE MET GLU ALA SER GLY LEU ILE GLU SER THR
SEQRES 37 I 678 ASN GLU LEU HIS LEU SER ASP SER GLU SER SER GLU THR
SEQRES 38 I 678 SER SER SER SER GLU GLU ASP MET GLU PHE ILE PRO PHE
SEQRES 39 I 678 SER ALA ARG ARG ASP SER ALA ASN THR ILE ASN SER GLU
SEQRES 40 I 678 ASP PHE ASP GLU GLY ASP PHE ASN LYS GLU ALA GLN GLN
SEQRES 41 I 678 SER LEU GLU ARG ALA PHE GLU GLU ASN HIS GLN ILE ASP
SEQRES 42 I 678 ILE ALA ALA LEU GLU LEU ASN THR LEU ARG MET ALA MET
SEQRES 43 I 678 ASN ALA ASN TYR HIS GLU VAL ARG SER ALA ILE VAL LEU
SEQRES 44 I 678 ALA LEU LEU ARG ARG ILE MET HIS LEU ASP VAL SER PRO
SEQRES 45 I 678 LYS GLU ALA LEU ALA LYS VAL MET THR ARG TRP GLY PRO
SEQRES 46 I 678 LEU LEU ALA LYS LEU THR PHE SER HIS GLU GLU GLN VAL
SEQRES 47 I 678 ASP ASN VAL LEU THR LEU GLN LYS TYR CYS VAL ARG LEU
SEQRES 48 I 678 SER MET THR ARG HIS PHE LEU GLN LEU LEU GLY TYR PHE
SEQRES 49 I 678 TYR GLN LEU GLU ILE ALA GLU GLU ASN ALA ILE GLN GLU
SEQRES 50 I 678 TRP TYR SER ASP PRO ARG SER SER GLU GLY GLU LEU ALA
SEQRES 51 I 678 ALA LEU ARG ASP ALA GLY GLY LYS GLN PHE VAL ASP TRP
SEQRES 52 I 678 LEU ASN THR ALA GLU SER GLU SER GLU SER GLU GLU GLY
SEQRES 53 I 678 SER GLU
SEQRES 1 J 678 MET PRO PRO SER LYS GLY LEU ASN GLY LYS LEU GLU LYS
SEQRES 2 J 678 PRO LYS HIS ALA LEU GLN ALA ILE VAL LEU SER ASP SER
SEQRES 3 J 678 TYR ASN TYR ARG PHE ARG PRO LEU THR LEU ASP LYS PRO
SEQRES 4 J 678 ARG CYS LEU LEU PRO LEU ALA ASN THR PRO LEU ILE GLU
SEQRES 5 J 678 TYR THR PHE GLU PHE LEU ALA LEU ALA GLY VAL GLN GLU
SEQRES 6 J 678 VAL TYR VAL PHE CYS CYS ALA HIS ALA GLY GLN ILE ARG
SEQRES 7 J 678 GLU TYR ILE GLU LYS SER LYS TRP ASN LEU PRO SER SER
SEQRES 8 J 678 PRO PHE SER VAL ASN THR ILE VAL SER ARG GLU SER LEU
SEQRES 9 J 678 SER VAL GLY ASP ALA LEU ARG GLU LEU ASP SER LYS GLN
SEQRES 10 J 678 LEU ILE THR SER ASP PHE ILE LEU VAL SER GLY ASP VAL
SEQRES 11 J 678 VAL SER ASN VAL PRO LEU ASN GLU VAL LEU LYS GLU HIS
SEQRES 12 J 678 ARG LYS ARG ARG GLU ASP ASP LYS ASN ALA ILE MET THR
SEQRES 13 J 678 MET VAL VAL ARG GLU ALA SER PRO PHE HIS ARG THR ARG
SEQRES 14 J 678 ALA ARG THR GLU SER SER VAL PHE VAL ILE ASP LYS LYS
SEQRES 15 J 678 THR SER GLN CYS VAL HIS TYR GLN ALA ASN GLU ARG GLY
SEQRES 16 J 678 LYS HIS TYR VAL SER MET ASP PRO GLU ILE PHE ASN GLU
SEQRES 17 J 678 HIS GLU GLU LEU GLU VAL ARG ASN ASP LEU ILE ASP CYS
SEQRES 18 J 678 GLN ILE ASP ILE CYS SER ASN ASP VAL PRO ALA LEU PHE
SEQRES 19 J 678 THR GLU ASN PHE ASP TYR GLN ASP ILE ARG LYS ASP PHE
SEQRES 20 J 678 VAL TYR GLY VAL LEU THR SER ASP LEU LEU GLY LYS LYS
SEQRES 21 J 678 ILE HIS CYS HIS VAL ALA LYS GLU ASN TYR ALA ALA ARG
SEQRES 22 J 678 VAL ARG SER LEU GLN THR TYR ASP ALA ILE SER LYS ASP
SEQRES 23 J 678 VAL LEU SER ARG TRP VAL TYR PRO PHE VAL PRO ASP SER
SEQRES 24 J 678 ASN LEU LEU ASN GLN THR PHE SER TYR GLN ARG HIS GLN
SEQRES 25 J 678 ILE TYR LYS GLU GLU ASP VAL VAL LEU ALA ARG SER CYS
SEQRES 26 J 678 ILE ILE LYS ALA ARG THR LEU ILE GLY ALA TYR THR LYS
SEQRES 27 J 678 VAL GLY ASP ALA SER VAL VAL ALA ASN THR ILE ILE GLY
SEQRES 28 J 678 ARG ASN CYS THR ILE GLY SER ASN CYS SER ILE ASP SER
SEQRES 29 J 678 ALA PHE LEU TRP GLU ASP VAL VAL ILE GLY ASP ASN CYS
SEQRES 30 J 678 ARG ILE GLY LYS ALA ILE LEU ALA ASN SER VAL LYS ILE
SEQRES 31 J 678 GLY ASN ASN CYS SER ILE GLU ASP GLY ALA ILE VAL ALA
SEQRES 32 J 678 ALA GLY VAL VAL ILE GLY ASP ASN THR ILE ILE GLU LYS
SEQRES 33 J 678 ASN LYS ARG LEU THR THR PHE GLU SER HIS SER GLN GLY
SEQRES 34 J 678 THR LEU ASN ASP PRO SER LEU VAL GLY ILE GLY GLY ARG
SEQRES 35 J 678 GLY GLN GLU TYR HIS ALA GLU GLU ASP SER ASP ASP GLU
SEQRES 36 J 678 GLY GLU PHE MET GLU ALA SER GLY LEU ILE GLU SER THR
SEQRES 37 J 678 ASN GLU LEU HIS LEU SER ASP SER GLU SER SER GLU THR
SEQRES 38 J 678 SER SER SER SER GLU GLU ASP MET GLU PHE ILE PRO PHE
SEQRES 39 J 678 SER ALA ARG ARG ASP SER ALA ASN THR ILE ASN SER GLU
SEQRES 40 J 678 ASP PHE ASP GLU GLY ASP PHE ASN LYS GLU ALA GLN GLN
SEQRES 41 J 678 SER LEU GLU ARG ALA PHE GLU GLU ASN HIS GLN ILE ASP
SEQRES 42 J 678 ILE ALA ALA LEU GLU LEU ASN THR LEU ARG MET ALA MET
SEQRES 43 J 678 ASN ALA ASN TYR HIS GLU VAL ARG SER ALA ILE VAL LEU
SEQRES 44 J 678 ALA LEU LEU ARG ARG ILE MET HIS LEU ASP VAL SER PRO
SEQRES 45 J 678 LYS GLU ALA LEU ALA LYS VAL MET THR ARG TRP GLY PRO
SEQRES 46 J 678 LEU LEU ALA LYS LEU THR PHE SER HIS GLU GLU GLN VAL
SEQRES 47 J 678 ASP ASN VAL LEU THR LEU GLN LYS TYR CYS VAL ARG LEU
SEQRES 48 J 678 SER MET THR ARG HIS PHE LEU GLN LEU LEU GLY TYR PHE
SEQRES 49 J 678 TYR GLN LEU GLU ILE ALA GLU GLU ASN ALA ILE GLN GLU
SEQRES 50 J 678 TRP TYR SER ASP PRO ARG SER SER GLU GLY GLU LEU ALA
SEQRES 51 J 678 ALA LEU ARG ASP ALA GLY GLY LYS GLN PHE VAL ASP TRP
SEQRES 52 J 678 LEU ASN THR ALA GLU SER GLU SER GLU SER GLU GLU GLY
SEQRES 53 J 678 SER GLU
SEQRES 1 L 304 MET SER THR SER HIS CYS ARG PHE TYR GLU ASN LYS TYR
SEQRES 2 L 304 PRO GLU ILE ASP ASP ILE VAL MET VAL ASN VAL GLN GLN
SEQRES 3 L 304 ILE ALA GLU MET GLY ALA TYR VAL LYS LEU LEU GLU TYR
SEQRES 4 L 304 ASP ASN ILE GLU GLY MET ILE LEU LEU SER GLU LEU SEP
SEQRES 5 L 304 ARG ARG ARG ILE ARG SER ILE GLN LYS LEU ILE ARG VAL
SEQRES 6 L 304 GLY LYS ASN ASP VAL ALA VAL VAL LEU ARG VAL ASP LYS
SEQRES 7 L 304 GLU LYS GLY TYR ILE ASP LEU SER LYS ARG ARG VAL SER
SEQRES 8 L 304 SER GLU ASP ILE ILE LYS CYS GLU GLU LYS TYR GLN LYS
SEQRES 9 L 304 SER LYS THR VAL HIS SER ILE LEU ARG TYR CYS ALA GLU
SEQRES 10 L 304 LYS PHE GLN ILE PRO LEU GLU GLU LEU TYR LYS THR ILE
SEQRES 11 L 304 ALA TRP PRO LEU SER ARG LYS PHE GLY HIS ALA TYR GLU
SEQRES 12 L 304 ALA PHE LYS LEU SER ILE ILE ASP GLU THR VAL TRP GLU
SEQRES 13 L 304 GLY ILE GLU PRO PRO SER LYS ASP VAL LEU ASP GLU LEU
SEQRES 14 L 304 LYS ASN TYR ILE SER LYS ARG LEU THR PRO GLN ALA VAL
SEQRES 15 L 304 LYS ILE ARG ALA ASP VAL GLU VAL SER CYS PHE SER TYR
SEQRES 16 L 304 GLU GLY ILE ASP ALA ILE LYS ASP ALA LEU LYS SER ALA
SEQRES 17 L 304 GLU ASP MET SER THR GLU GLN MET GLN VAL LYS VAL LYS
SEQRES 18 L 304 LEU VAL ALA ALA PRO LEU TYR VAL LEU THR THR GLN ALA
SEQRES 19 L 304 LEU ASP LYS GLN LYS GLY ILE GLU GLN LEU GLU SER ALA
SEQRES 20 L 304 ILE GLU LYS ILE THR GLU VAL ILE THR LYS TYR GLY GLY
SEQRES 21 L 304 VAL CYS ASN ILE THR MET PRO PRO LYS ALA VAL THR ALA
SEQRES 22 L 304 THR GLU ASP ALA GLU LEU GLN ALA LEU LEU GLU SER LYS
SEQRES 23 L 304 GLU LEU ASP ASN ARG SER ASP SER GLU ASP ASP GLU ASP
SEQRES 24 L 304 GLU SER ASP ASP GLU
SEQRES 1 M 304 MET SER THR SER HIS CYS ARG PHE TYR GLU ASN LYS TYR
SEQRES 2 M 304 PRO GLU ILE ASP ASP ILE VAL MET VAL ASN VAL GLN GLN
SEQRES 3 M 304 ILE ALA GLU MET GLY ALA TYR VAL LYS LEU LEU GLU TYR
SEQRES 4 M 304 ASP ASN ILE GLU GLY MET ILE LEU LEU SER GLU LEU SEP
SEQRES 5 M 304 ARG ARG ARG ILE ARG SER ILE GLN LYS LEU ILE ARG VAL
SEQRES 6 M 304 GLY LYS ASN ASP VAL ALA VAL VAL LEU ARG VAL ASP LYS
SEQRES 7 M 304 GLU LYS GLY TYR ILE ASP LEU SER LYS ARG ARG VAL SER
SEQRES 8 M 304 SER GLU ASP ILE ILE LYS CYS GLU GLU LYS TYR GLN LYS
SEQRES 9 M 304 SER LYS THR VAL HIS SER ILE LEU ARG TYR CYS ALA GLU
SEQRES 10 M 304 LYS PHE GLN ILE PRO LEU GLU GLU LEU TYR LYS THR ILE
SEQRES 11 M 304 ALA TRP PRO LEU SER ARG LYS PHE GLY HIS ALA TYR GLU
SEQRES 12 M 304 ALA PHE LYS LEU SER ILE ILE ASP GLU THR VAL TRP GLU
SEQRES 13 M 304 GLY ILE GLU PRO PRO SER LYS ASP VAL LEU ASP GLU LEU
SEQRES 14 M 304 LYS ASN TYR ILE SER LYS ARG LEU THR PRO GLN ALA VAL
SEQRES 15 M 304 LYS ILE ARG ALA ASP VAL GLU VAL SER CYS PHE SER TYR
SEQRES 16 M 304 GLU GLY ILE ASP ALA ILE LYS ASP ALA LEU LYS SER ALA
SEQRES 17 M 304 GLU ASP MET SER THR GLU GLN MET GLN VAL LYS VAL LYS
SEQRES 18 M 304 LEU VAL ALA ALA PRO LEU TYR VAL LEU THR THR GLN ALA
SEQRES 19 M 304 LEU ASP LYS GLN LYS GLY ILE GLU GLN LEU GLU SER ALA
SEQRES 20 M 304 ILE GLU LYS ILE THR GLU VAL ILE THR LYS TYR GLY GLY
SEQRES 21 M 304 VAL CYS ASN ILE THR MET PRO PRO LYS ALA VAL THR ALA
SEQRES 22 M 304 THR GLU ASP ALA GLU LEU GLN ALA LEU LEU GLU SER LYS
SEQRES 23 M 304 GLU LEU ASP ASN ARG SER ASP SER GLU ASP ASP GLU ASP
SEQRES 24 M 304 GLU SER ASP ASP GLU
MODRES 6JLZ SEP L 51 SER MODIFIED RESIDUE
MODRES 6JLZ SEP M 51 SER MODIFIED RESIDUE
HET SEP L 51 10
HET SEP M 51 10
HET PO4 A 401 5
HET PO4 B 401 5
HET PO4 C 401 5
HET PO4 D 401 5
HET PO4 E 501 5
HET PO4 E 502 5
HET PO4 F 501 5
HET PO4 F 502 5
HET PO4 G 501 5
HET PO4 H 501 5
HET PO4 I 701 5
HET PO4 J 701 5
HETNAM SEP PHOSPHOSERINE
HETNAM PO4 PHOSPHATE ION
HETSYN SEP PHOSPHONOSERINE
FORMUL 11 SEP 2(C3 H8 N O6 P)
FORMUL 13 PO4 12(O4 P 3-)
HELIX 1 AA1 ILE A 19 ASP A 30 1 12
HELIX 2 AA2 THR A 34 ARG A 49 1 16
HELIX 3 AA3 THR A 54 VAL A 73 1 20
HELIX 4 AA4 ASN A 76 THR A 91 1 16
HELIX 5 AA5 PHE A 100 ALA A 120 1 21
HELIX 6 AA6 ALA A 120 TYR A 130 1 11
HELIX 7 AA7 PRO A 131 ILE A 133 5 3
HELIX 8 AA8 SER A 145 ARG A 158 1 14
HELIX 9 AA9 GLY A 173 ASN A 184 1 12
HELIX 10 AB1 LEU A 193 VAL A 204 5 12
HELIX 11 AB2 GLY A 225 ALA A 236 1 12
HELIX 12 AB3 GLU A 245 PHE A 249 5 5
HELIX 13 AB4 ASN A 298 ASN A 305 1 8
HELIX 14 AB5 PRO A 312 VAL A 316 5 5
HELIX 15 AB6 SER A 330 TYR A 340 1 11
HELIX 16 AB7 ILE B 19 ASP B 30 1 12
HELIX 17 AB8 THR B 34 ARG B 49 1 16
HELIX 18 AB9 THR B 54 VAL B 73 1 20
HELIX 19 AC1 ASN B 76 THR B 91 1 16
HELIX 20 AC2 PHE B 100 ALA B 120 1 21
HELIX 21 AC3 ALA B 120 TYR B 130 1 11
HELIX 22 AC4 PRO B 131 ILE B 133 5 3
HELIX 23 AC5 SER B 145 LYS B 157 1 13
HELIX 24 AC6 SER B 174 ASN B 184 1 11
HELIX 25 AC7 LEU B 193 SER B 195 5 3
HELIX 26 AC8 ALA B 196 MET B 201 1 6
HELIX 27 AC9 ASN B 202 VAL B 204 5 3
HELIX 28 AD1 GLY B 225 ALA B 236 1 12
HELIX 29 AD2 GLU B 245 PHE B 249 5 5
HELIX 30 AD3 ASN B 298 ASN B 305 1 8
HELIX 31 AD4 PRO B 312 VAL B 316 5 5
HELIX 32 AD5 SER B 330 TYR B 340 1 11
HELIX 33 AD6 SER C 2 TYR C 10 1 9
HELIX 34 AD7 TYR C 10 SER C 22 1 13
HELIX 35 AD8 GLY C 27 SER C 44 1 18
HELIX 36 AD9 THR C 50 ALA C 68 1 19
HELIX 37 AE1 PHE C 73 GLU C 99 1 27
HELIX 38 AE2 MET C 169 ASP C 185 1 17
HELIX 39 AE3 ILE C 191 HIS C 198 5 8
HELIX 40 AE4 SER C 211 LYS C 223 1 13
HELIX 41 AE5 ASN C 238 ALA C 252 1 15
HELIX 42 AE6 SER C 260 ALA C 262 5 3
HELIX 43 AE7 THR C 263 SER C 269 1 7
HELIX 44 AE8 ALA C 293 HIS C 302 1 10
HELIX 45 AE9 ASP C 323 ILE C 327 5 5
HELIX 46 AF1 SER C 332 ILE C 336 5 5
HELIX 47 AF2 GLU C 341 ALA C 348 1 8
HELIX 48 AF3 PRO C 359 VAL C 363 5 5
HELIX 49 AF4 PRO C 374 SER C 376 5 3
HELIX 50 AF5 TYR C 377 ASP C 384 1 8
HELIX 51 AF6 ASP C 387 THR C 391 5 5
HELIX 52 AF7 SER D 2 TYR D 10 1 9
HELIX 53 AF8 TYR D 10 SER D 22 1 13
HELIX 54 AF9 GLY D 27 THR D 46 1 20
HELIX 55 AG1 THR D 50 GLN D 69 1 20
HELIX 56 AG2 PHE D 73 GLU D 101 1 29
HELIX 57 AG3 GLY D 166 ASP D 168 5 3
HELIX 58 AG4 MET D 169 ASP D 185 1 17
HELIX 59 AG5 LYS D 186 GLU D 192 1 7
HELIX 60 AG6 VAL D 193 HIS D 198 5 6
HELIX 61 AG7 SER D 211 LYS D 223 1 13
HELIX 62 AG8 ASN D 238 ALA D 252 1 15
HELIX 63 AG9 THR D 263 MET D 268 1 6
HELIX 64 AH1 SER D 269 VAL D 271 5 3
HELIX 65 AH2 ALA D 293 HIS D 303 1 11
HELIX 66 AH3 ASP D 323 ILE D 327 5 5
HELIX 67 AH4 SER D 332 ILE D 336 5 5
HELIX 68 AH5 GLU D 341 ARG D 347 1 7
HELIX 69 AH6 PRO D 359 VAL D 363 5 5
HELIX 70 AH7 PRO D 374 TYR D 377 5 4
HELIX 71 AH8 LEU D 378 TYR D 386 1 9
HELIX 72 AH9 ASP D 387 ILE D 392 5 6
HELIX 73 AI1 LEU E 51 GLY E 56 1 6
HELIX 74 AI2 PRO E 61 LEU E 65 5 5
HELIX 75 AI3 LEU E 73 GLY E 84 1 12
HELIX 76 AI4 ALA E 96 SER E 106 1 11
HELIX 77 AI5 SER E 127 VAL E 135 1 9
HELIX 78 AI6 SER E 136 ILE E 139 5 4
HELIX 79 AI7 PRO E 156 ASN E 167 1 12
HELIX 80 AI8 ARG E 221 TRP E 226 1 6
HELIX 81 AI9 TRP E 248 LYS E 256 1 9
HELIX 82 AJ1 ASP E 265 GLN E 276 1 12
HELIX 83 AJ2 TYR E 329 LYS E 338 1 10
HELIX 84 AJ3 PRO F 61 LEU F 65 5 5
HELIX 85 AJ4 LEU F 73 GLY F 84 1 12
HELIX 86 AJ5 ALA F 96 SER F 106 1 11
HELIX 87 AJ6 SER F 127 VAL F 135 1 9
HELIX 88 AJ7 SER F 136 ILE F 139 5 4
HELIX 89 AJ8 PRO F 156 ASN F 167 1 12
HELIX 90 AJ9 TRP F 248 LYS F 256 1 9
HELIX 91 AK1 ASP F 265 GLN F 276 1 12
HELIX 92 AK2 TYR F 329 LEU F 339 1 11
HELIX 93 AK3 ALA G 107 GLU G 117 1 11
HELIX 94 AK4 HIS G 142 TYR G 155 1 14
HELIX 95 AK5 GLY G 159 TYR G 178 1 20
HELIX 96 AK6 LEU G 190 ARG G 205 1 16
HELIX 97 AK7 SER G 208 LEU G 225 1 18
HELIX 98 AK8 THR G 230 ILE G 250 1 21
HELIX 99 AK9 ILE G 250 LYS G 264 1 15
HELIX 100 AL1 SER G 277 VAL G 290 1 14
HELIX 101 AL2 GLU G 306 GLU G 316 1 11
HELIX 102 AL3 ALA G 328 MET G 333 1 6
HELIX 103 AL4 GLY G 357 GLU G 367 1 11
HELIX 104 AL5 GLU G 377 PHE G 381 5 5
HELIX 105 AL6 PRO G 397 VAL G 402 5 6
HELIX 106 AL7 PRO G 436 ILE G 440 5 5
HELIX 107 AL8 PRO G 451 THR G 453 5 3
HELIX 108 AL9 SER G 454 LYS G 463 1 10
HELIX 109 AM1 ALA H 107 GLU H 117 1 11
HELIX 110 AM2 SER H 121 HIS H 125 5 5
HELIX 111 AM3 HIS H 142 TYR H 155 1 14
HELIX 112 AM4 GLY H 159 TYR H 178 1 20
HELIX 113 AM5 LEU H 190 ARG H 205 1 16
HELIX 114 AM6 SER H 208 VAL H 224 1 17
HELIX 115 AM7 THR H 230 ARG H 249 1 20
HELIX 116 AM8 ILE H 250 LYS H 264 1 15
HELIX 117 AM9 SER H 277 VAL H 290 1 14
HELIX 118 AN1 GLU H 306 HIS H 317 1 12
HELIX 119 AN2 ALA H 328 MET H 333 1 6
HELIX 120 AN3 GLN H 334 VAL H 336 5 3
HELIX 121 AN4 GLY H 357 GLU H 367 1 11
HELIX 122 AN5 PRO H 397 VAL H 402 5 6
HELIX 123 AN6 PRO H 451 THR H 453 5 3
HELIX 124 AN7 SER H 454 LYS H 463 1 10
HELIX 125 AN8 PRO I 14 ALA I 17 5 4
HELIX 126 AN9 PHE I 31 LEU I 36 1 6
HELIX 127 AO1 PRO I 39 LEU I 43 5 5
HELIX 128 AO2 PRO I 49 ALA I 61 1 13
HELIX 129 AO3 HIS I 73 SER I 84 1 12
HELIX 130 AO4 GLY I 107 SER I 115 1 9
HELIX 131 AO5 LEU I 136 ASP I 149 1 14
HELIX 132 AO6 ASP I 202 HIS I 209 5 8
HELIX 133 AO7 ASP I 229 ASN I 237 1 9
HELIX 134 AO8 ASP I 246 THR I 253 1 8
HELIX 135 AO9 SER I 276 SER I 289 1 14
HELIX 136 AP1 ARG I 290 TYR I 293 5 4
HELIX 137 AP2 VAL I 296 ASN I 300 5 5
HELIX 138 AP3 PHE J 31 THR J 35 5 5
HELIX 139 AP4 PRO J 39 LEU J 43 5 5
HELIX 140 AP5 PRO J 49 GLY J 62 1 14
HELIX 141 AP6 HIS J 73 SER J 84 1 12
HELIX 142 AP7 LYS J 85 LEU J 88 5 4
HELIX 143 AP8 SER J 105 SER J 115 1 11
HELIX 144 AP9 GLU J 138 GLU J 148 1 11
HELIX 145 AQ1 ASP J 202 HIS J 209 5 8
HELIX 146 AQ2 ASN J 228 GLU J 236 1 9
HELIX 147 AQ3 ASP J 246 THR J 253 1 8
HELIX 148 AQ4 SER J 276 SER J 289 1 14
HELIX 149 AQ5 VAL J 296 ASN J 300 5 5
HELIX 150 AQ6 GLU L 37 ASP L 39 5 3
HELIX 151 AQ7 GLU L 92 ALA L 115 1 24
HELIX 152 AQ8 GLU L 123 ILE L 129 1 7
HELIX 153 AQ9 ILE L 129 GLY L 138 1 10
HELIX 154 AR1 ALA L 140 LYS L 145 1 6
HELIX 155 AR2 LEU L 146 ILE L 149 5 4
HELIX 156 AR3 GLU L 151 GLU L 155 5 5
HELIX 157 AR4 SER L 161 ILE L 172 1 12
HELIX 158 AR5 GLU M 37 ASP M 39 5 3
HELIX 159 AR6 GLU M 92 ALA M 115 1 24
HELIX 160 AR7 GLU M 123 ILE M 129 1 7
HELIX 161 AR8 ILE M 129 PHE M 137 1 9
HELIX 162 AR9 ALA M 143 ILE M 148 1 6
HELIX 163 AS1 GLU M 151 GLU M 155 5 5
HELIX 164 AS2 SER M 161 TYR M 171 1 11
SHEET 1 AA1 7 MET A 191 VAL A 192 0
SHEET 2 AA1 7 PHE A 162 THR A 167 1 N VAL A 166 O VAL A 192
SHEET 3 AA1 7 SER A 137 THR A 141 1 N ILE A 139 O LYS A 163
SHEET 4 AA1 7 LEU A 206 GLY A 210 1 O LEU A 208 N LEU A 140
SHEET 5 AA1 7 TYR A 241 VAL A 243 1 O TYR A 241 N VAL A 207
SHEET 6 AA1 7 GLY A 318 THR A 321 1 O ILE A 320 N ALA A 242
SHEET 7 AA1 7 GLY A 324 ILE A 326 -1 O ILE A 326 N LEU A 319
SHEET 1 AA2 2 LEU A 220 GLN A 223 0
SHEET 2 AA2 2 LEU A 308 THR A 311 -1 O THR A 311 N LEU A 220
SHEET 1 AA3 7 THR B 189 VAL B 192 0
SHEET 2 AA3 7 PHE B 162 THR B 167 1 N VAL B 166 O VAL B 192
SHEET 3 AA3 7 SER B 137 THR B 141 1 N ILE B 139 O PHE B 165
SHEET 4 AA3 7 LEU B 206 GLY B 210 1 O LEU B 208 N LEU B 140
SHEET 5 AA3 7 PHE B 240 VAL B 243 1 O VAL B 243 N VAL B 209
SHEET 6 AA3 7 GLY B 318 THR B 321 1 O ILE B 320 N ALA B 242
SHEET 7 AA3 7 GLY B 324 ILE B 326 -1 O ILE B 326 N LEU B 319
SHEET 1 AA4 3 GLY B 213 VAL B 214 0
SHEET 2 AA4 3 LEU B 220 GLN B 223 -1 O ILE B 221 N GLY B 213
SHEET 3 AA4 3 LEU B 308 THR B 311 -1 O ASP B 309 N ASN B 222
SHEET 1 AA5 8 GLY C 371 TYR C 373 0
SHEET 2 AA5 8 LEU C 365 THR C 368 -1 N THR C 368 O GLY C 371
SHEET 3 AA5 8 VAL C 307 CYS C 310 1 N VAL C 309 O ILE C 367
SHEET 4 AA5 8 LYS C 273 LEU C 276 1 N VAL C 274 O VAL C 308
SHEET 5 AA5 8 ILE C 204 GLN C 208 1 N LEU C 206 O ILE C 275
SHEET 6 AA5 8 SER C 228 ALA C 232 1 O ILE C 230 N THR C 207
SHEET 7 AA5 8 THR C 256 ILE C 259 1 O THR C 257 N VAL C 231
SHEET 8 AA5 8 LEU G 425 LEU G 427 1 O LYS G 426 N THR C 256
SHEET 1 AA6 3 ALA C 280 ILE C 281 0
SHEET 2 AA6 3 LEU C 287 TYR C 290 -1 O VAL C 288 N ALA C 280
SHEET 3 AA6 3 TYR C 355 ILE C 358 -1 O ASP C 356 N THR C 289
SHEET 1 AA7 2 LEU C 330 SER C 331 0
SHEET 2 AA7 2 ASN C 352 PRO C 353 -1 O ASN C 352 N SER C 331
SHEET 1 AA8 8 GLU C 349 ILE C 350 0
SHEET 2 AA8 8 CYS G 321 MET G 325 1 O TYR G 323 N GLU C 349
SHEET 3 AA8 8 PHE G 294 ASP G 300 1 N VAL G 298 O THR G 322
SHEET 4 AA8 8 ASP G 269 TYR G 274 1 N ILE G 271 O VAL G 297
SHEET 5 AA8 8 LYS G 338 GLY G 342 1 O PHE G 340 N LEU G 272
SHEET 6 AA8 8 VAL G 372 CYS G 375 1 O CYS G 375 N LEU G 341
SHEET 7 AA8 8 VAL G 442 CYS G 445 1 O VAL G 444 N ALA G 374
SHEET 8 AA8 8 GLY G 448 LEU G 450 -1 O LEU G 450 N CYS G 443
SHEET 1 AA9 8 GLY D 371 TYR D 373 0
SHEET 2 AA9 8 LEU D 365 THR D 368 -1 N PHE D 366 O TYR D 373
SHEET 3 AA9 8 VAL D 307 CYS D 310 1 N VAL D 309 O ILE D 367
SHEET 4 AA9 8 LYS D 273 LEU D 276 1 N VAL D 274 O VAL D 308
SHEET 5 AA9 8 ILE D 204 GLN D 208 1 N LEU D 206 O ILE D 275
SHEET 6 AA9 8 SER D 228 ALA D 232 1 O ILE D 230 N ILE D 205
SHEET 7 AA9 8 ASP D 255 ILE D 259 1 O THR D 257 N VAL D 231
SHEET 8 AA9 8 LEU H 425 LEU H 427 1 O LYS H 426 N THR D 256
SHEET 1 AB1 3 ALA D 280 ILE D 281 0
SHEET 2 AB1 3 LEU D 287 TYR D 290 -1 O VAL D 288 N ALA D 280
SHEET 3 AB1 3 TYR D 355 ILE D 358 -1 O ASP D 356 N THR D 289
SHEET 1 AB2 2 LEU D 330 SER D 331 0
SHEET 2 AB2 2 ASN D 352 PRO D 353 -1 O ASN D 352 N SER D 331
SHEET 1 AB3 8 ALA D 348 ILE D 350 0
SHEET 2 AB3 8 CYS H 321 MET H 325 1 O TYR H 323 N GLU D 349
SHEET 3 AB3 8 PHE H 294 ASP H 300 1 N VAL H 298 O THR H 322
SHEET 4 AB3 8 ASP H 269 TYR H 274 1 N ILE H 271 O VAL H 297
SHEET 5 AB3 8 LYS H 338 GLY H 342 1 O PHE H 340 N LEU H 272
SHEET 6 AB3 8 VAL H 372 CYS H 375 1 O CYS H 375 N LEU H 341
SHEET 7 AB3 8 VAL H 442 CYS H 445 1 O VAL H 444 N ALA H 374
SHEET 8 AB3 8 GLY H 448 LEU H 450 -1 O LEU H 450 N CYS H 443
SHEET 1 AB4 7 ARG E 113 GLU E 117 0
SHEET 2 AB4 7 SER E 87 CYS E 92 1 N LEU E 90 O HIS E 115
SHEET 3 AB4 7 PHE E 39 ALA E 45 1 N ALA E 41 O ILE E 89
SHEET 4 AB4 7 ASP E 142 CYS E 145 1 O VAL E 144 N VAL E 42
SHEET 5 AB4 7 LEU E 237 PHE E 245 -1 O PHE E 243 N CYS E 145
SHEET 6 AB4 7 ALA E 170 PRO E 176 -1 N SER E 175 O SER E 238
SHEET 7 AB4 7 ASP E 316 ILE E 319 1 O ILE E 318 N TYR E 174
SHEET 1 AB5 2 ILE E 151 VAL E 152 0
SHEET 2 AB5 2 ASN E 324 ASN E 325 -1 O ASN E 325 N ILE E 151
SHEET 1 AB6 6 ARG E 204 SER E 210 0
SHEET 2 AB6 6 GLN E 194 GLU E 199 -1 N GLY E 197 O LEU E 206
SHEET 3 AB6 6 ARG E 230 ASN E 234 -1 O ASN E 234 N ILE E 196
SHEET 4 AB6 6 GLU J 211 ARG J 215 -1 O LEU J 212 N LEU E 233
SHEET 5 AB6 6 SER J 175 ASP J 180 -1 N ILE J 179 O GLU J 213
SHEET 6 AB6 6 CYS J 186 ALA J 191 -1 O VAL J 187 N VAL J 178
SHEET 1 AB7 6 VAL E 350 SER E 351 0
SHEET 2 AB7 6 THR E 367 ILE E 368 1 O ILE E 368 N VAL E 350
SHEET 3 AB7 6 VAL E 384 ILE E 385 1 O ILE E 385 N THR E 367
SHEET 4 AB7 6 VAL E 401 VAL E 402 1 O VAL E 402 N VAL E 384
SHEET 5 AB7 6 GLN E 418 ILE E 419 1 O ILE E 419 N VAL E 401
SHEET 6 AB7 6 ARG E 435 VAL E 436 1 O VAL E 436 N GLN E 418
SHEET 1 AB8 8 MET E 361 VAL E 362 0
SHEET 2 AB8 8 ILE E 378 ILE E 379 1 O ILE E 379 N MET E 361
SHEET 3 AB8 8 ILE E 395 LEU E 396 1 O LEU E 396 N ILE E 378
SHEET 4 AB8 8 ILE E 412 VAL E 413 1 O VAL E 413 N ILE E 395
SHEET 5 AB8 8 LYS E 424 ILE E 430 1 O CYS E 428 N ILE E 412
SHEET 6 AB8 8 ARG E 407 GLU E 409 1 N GLU E 409 O LEU E 425
SHEET 7 AB8 8 VAL E 390 SER E 392 1 N VAL E 390 O LEU E 408
SHEET 8 AB8 8 ASN E 373 LYS E 375 1 N LYS E 375 O VAL E 391
SHEET 1 AB9 6 MET E 361 VAL E 362 0
SHEET 2 AB9 6 ILE E 378 ILE E 379 1 O ILE E 379 N MET E 361
SHEET 3 AB9 6 ILE E 395 LEU E 396 1 O LEU E 396 N ILE E 378
SHEET 4 AB9 6 ILE E 412 VAL E 413 1 O VAL E 413 N ILE E 395
SHEET 5 AB9 6 LYS E 424 ILE E 430 1 O CYS E 428 N ILE E 412
SHEET 6 AB9 6 ARG E 440 ARG E 446 1 O ARG E 446 N GLU E 429
SHEET 1 AC1 7 ARG F 113 GLU F 117 0
SHEET 2 AC1 7 SER F 87 CYS F 92 1 N LEU F 90 O HIS F 115
SHEET 3 AC1 7 PHE F 39 ALA F 45 1 N ALA F 41 O ILE F 89
SHEET 4 AC1 7 ASP F 142 CYS F 145 1 O VAL F 144 N VAL F 42
SHEET 5 AC1 7 ARG F 230 PHE F 245 -1 O PHE F 243 N CYS F 145
SHEET 6 AC1 7 ALA F 170 SER F 175 -1 N SER F 175 O SER F 238
SHEET 7 AC1 7 ASP F 316 ILE F 318 1 O ILE F 318 N TYR F 174
SHEET 1 AC2 6 LEU F 205 SER F 210 0
SHEET 2 AC2 6 GLN F 194 ILE F 198 -1 N GLY F 197 O TYR F 207
SHEET 3 AC2 6 ARG F 230 PHE F 245 -1 O THR F 232 N ILE F 198
SHEET 4 AC2 6 GLU I 211 ARG I 215 -1 O VAL I 214 N VAL F 231
SHEET 5 AC2 6 SER I 175 ASP I 180 -1 N PHE I 177 O ARG I 215
SHEET 6 AC2 6 CYS I 186 ALA I 191 -1 O VAL I 187 N VAL I 178
SHEET 1 AC3 2 ILE F 151 VAL F 152 0
SHEET 2 AC3 2 ASN F 324 ASN F 325 -1 O ASN F 325 N ILE F 151
SHEET 1 AC4 2 PHE F 220 ARG F 221 0
SHEET 2 AC4 2 TYR I 198 VAL I 199 -1 O VAL I 199 N PHE F 220
SHEET 1 AC5 5 VAL F 350 SER F 351 0
SHEET 2 AC5 5 THR F 367 ILE F 368 1 O ILE F 368 N VAL F 350
SHEET 3 AC5 5 VAL F 384 ILE F 385 1 O ILE F 385 N THR F 367
SHEET 4 AC5 5 VAL F 401 VAL F 402 1 O VAL F 402 N VAL F 384
SHEET 5 AC5 5 GLN F 418 ILE F 419 1 O ILE F 419 N VAL F 401
SHEET 1 AC6 6 VAL F 356 ALA F 358 0
SHEET 2 AC6 6 ASN F 373 LYS F 375 1 O ILE F 374 N VAL F 356
SHEET 3 AC6 6 VAL F 390 SER F 392 1 O VAL F 391 N ASN F 373
SHEET 4 AC6 6 ARG F 407 GLU F 409 1 O LEU F 408 N SER F 392
SHEET 5 AC6 6 LYS F 424 ARG F 426 1 O LEU F 425 N GLU F 409
SHEET 6 AC6 6 ARG F 440 ALA F 442 1 O ILE F 441 N ARG F 426
SHEET 1 AC7 6 MET F 361 VAL F 362 0
SHEET 2 AC7 6 ILE F 378 ILE F 379 1 O ILE F 379 N MET F 361
SHEET 3 AC7 6 ILE F 395 LEU F 396 1 O LEU F 396 N ILE F 378
SHEET 4 AC7 6 ILE F 412 VAL F 413 1 O VAL F 413 N ILE F 395
SHEET 5 AC7 6 GLU F 429 ILE F 430 1 O ILE F 430 N ILE F 412
SHEET 6 AC7 6 GLU F 445 ARG F 446 1 O ARG F 446 N GLU F 429
SHEET 1 AC8 3 ALA G 345 MET G 346 0
SHEET 2 AC8 3 LEU G 352 SER G 354 -1 O TYR G 353 N ALA G 345
SHEET 3 AC8 3 ASP G 433 THR G 435 -1 O ASP G 433 N SER G 354
SHEET 1 AC9 3 ALA H 345 MET H 346 0
SHEET 2 AC9 3 LEU H 352 ARG H 355 -1 O TYR H 353 N ALA H 345
SHEET 3 AC9 3 TYR H 432 THR H 435 -1 O ASP H 433 N SER H 354
SHEET 1 AD1 2 LEU H 395 ALA H 396 0
SHEET 2 AD1 2 SER H 429 LEU H 430 -1 O SER H 429 N ALA H 396
SHEET 1 AD2 7 SER I 94 VAL I 99 0
SHEET 2 AD2 7 GLU I 65 CYS I 70 1 N VAL I 68 O ILE I 98
SHEET 3 AD2 7 GLN I 19 LEU I 23 1 N VAL I 22 O TYR I 67
SHEET 4 AD2 7 PHE I 123 SER I 127 1 O VAL I 126 N LEU I 23
SHEET 5 AD2 7 ILE I 225 CYS I 226 -1 O CYS I 226 N PHE I 123
SHEET 6 AD2 7 ALA I 153 ARG I 160 -1 N THR I 156 O ILE I 225
SHEET 7 AD2 7 LYS I 260 ALA I 266 1 O ALA I 266 N VAL I 159
SHEET 1 AD3 2 ASP I 129 SER I 132 0
SHEET 2 AD3 2 ALA I 271 VAL I 274 -1 O ALA I 272 N VAL I 131
SHEET 1 AD4 7 SER I 307 GLN I 309 0
SHEET 2 AD4 7 ILE I 313 LYS I 315 -1 O ILE I 313 N GLN I 309
SHEET 3 AD4 7 LEU I 332 ILE I 333 1 O ILE I 333 N TYR I 314
SHEET 4 AD4 7 ILE I 349 ILE I 350 1 O ILE I 350 N LEU I 332
SHEET 5 AD4 7 PHE I 366 LEU I 367 1 O LEU I 367 N ILE I 349
SHEET 6 AD4 7 ILE I 383 LEU I 384 1 O LEU I 384 N PHE I 366
SHEET 7 AD4 7 ILE I 401 VAL I 402 1 O VAL I 402 N ILE I 383
SHEET 1 AD5 6 VAL I 320 LEU I 321 0
SHEET 2 AD5 6 LYS I 338 VAL I 339 1 O VAL I 339 N VAL I 320
SHEET 3 AD5 6 THR I 355 ILE I 356 1 O ILE I 356 N LYS I 338
SHEET 4 AD5 6 VAL I 372 ILE I 373 1 O ILE I 373 N THR I 355
SHEET 5 AD5 6 LYS I 389 ILE I 390 1 O ILE I 390 N VAL I 372
SHEET 6 AD5 6 VAL I 407 ILE I 408 1 O ILE I 408 N LYS I 389
SHEET 1 AD6 2 ILE I 326 ILE I 327 0
SHEET 2 AD6 2 VAL I 344 VAL I 345 1 O VAL I 345 N ILE I 326
SHEET 1 AD7 3 ARG I 378 ILE I 379 0
SHEET 2 AD7 3 SER I 395 ILE I 396 1 O ILE I 396 N ARG I 378
SHEET 3 AD7 3 ILE I 413 ILE I 414 1 O ILE I 414 N SER I 395
SHEET 1 AD8 7 SER J 94 VAL J 99 0
SHEET 2 AD8 7 GLU J 65 CYS J 70 1 N VAL J 68 O ILE J 98
SHEET 3 AD8 7 GLN J 19 LEU J 23 1 N VAL J 22 O PHE J 69
SHEET 4 AD8 7 PHE J 123 SER J 127 1 O VAL J 126 N LEU J 23
SHEET 5 AD8 7 ILE J 223 CYS J 226 -1 O CYS J 226 N PHE J 123
SHEET 6 AD8 7 ALA J 153 ARG J 160 -1 N THR J 156 O ILE J 225
SHEET 7 AD8 7 LYS J 260 ALA J 266 1 O HIS J 262 N MET J 157
SHEET 1 AD9 2 ASP J 129 SER J 132 0
SHEET 2 AD9 2 ALA J 271 VAL J 274 -1 O ALA J 272 N VAL J 131
SHEET 1 AE1 6 PHE J 306 GLN J 309 0
SHEET 2 AE1 6 ILE J 313 GLU J 316 -1 O ILE J 313 N GLN J 309
SHEET 3 AE1 6 THR J 331 ILE J 333 1 O THR J 331 N TYR J 314
SHEET 4 AE1 6 ILE J 349 ILE J 350 1 O ILE J 350 N LEU J 332
SHEET 5 AE1 6 PHE J 366 LEU J 367 1 O LEU J 367 N ILE J 349
SHEET 6 AE1 6 ILE J 383 LEU J 384 1 O LEU J 384 N PHE J 366
SHEET 1 AE2 3 VAL J 320 LEU J 321 0
SHEET 2 AE2 3 LYS J 338 VAL J 339 1 O VAL J 339 N VAL J 320
SHEET 3 AE2 3 THR J 355 ILE J 356 1 O ILE J 356 N LYS J 338
SHEET 1 AE3 4 ILE J 326 ILE J 327 0
SHEET 2 AE3 4 VAL J 344 ALA J 346 1 O VAL J 345 N ILE J 326
SHEET 3 AE3 4 SER J 361 ASP J 363 1 O ILE J 362 N VAL J 344
SHEET 4 AE3 4 ARG J 378 GLY J 380 1 O ILE J 379 N SER J 361
SHEET 1 AE4 3 VAL J 372 ILE J 373 0
SHEET 2 AE4 3 LYS J 389 ILE J 390 1 O ILE J 390 N VAL J 372
SHEET 3 AE4 3 VAL J 407 ILE J 408 1 O ILE J 408 N LYS J 389
SHEET 1 AE5 6 ILE L 18 ILE L 26 0
SHEET 2 AE5 6 GLY L 30 LEU L 35 -1 O LYS L 34 N ASN L 22
SHEET 3 AE5 6 ILE L 41 LEU L 46 -1 O GLY L 43 N VAL L 33
SHEET 4 AE5 6 ILE L 82 SER L 85 1 O ILE L 82 N MET L 44
SHEET 5 AE5 6 ASN L 67 VAL L 75 -1 N LEU L 73 O ASP L 83
SHEET 6 AE5 6 ILE L 18 ILE L 26 -1 N VAL L 21 O ASP L 68
SHEET 1 AE6 6 ILE M 18 ILE M 26 0
SHEET 2 AE6 6 GLY M 30 LEU M 35 -1 O TYR M 32 N GLN M 24
SHEET 3 AE6 6 GLU M 42 LEU M 46 -1 O GLY M 43 N VAL M 33
SHEET 4 AE6 6 ILE M 82 SER M 85 1 O ILE M 82 N MET M 44
SHEET 5 AE6 6 ASN M 67 VAL M 75 -1 N VAL M 71 O SER M 85
SHEET 6 AE6 6 ILE M 18 ILE M 26 -1 N VAL M 21 O ASP M 68
LINK C LEU L 50 N SEP L 51 1555 1555 1.33
LINK C SEP L 51 N ARG L 52 1555 1555 1.33
LINK C LEU M 50 N SEP M 51 1555 1555 1.33
LINK C SEP M 51 N ARG M 52 1555 1555 1.33
CISPEP 1 ARG A 170 PRO A 171 0 -0.38
CISPEP 2 ARG B 170 PRO B 171 0 -6.17
CISPEP 3 PHE C 235 PRO C 236 0 0.86
CISPEP 4 PHE D 235 PRO D 236 0 1.23
CISPEP 5 ARG G 302 PRO G 303 0 -6.56
CISPEP 6 ARG H 302 PRO H 303 0 -7.09
CISPEP 7 TYR I 293 PRO I 294 0 -0.36
CISPEP 8 ASP I 433 PRO I 434 0 -9.07
CISPEP 9 TYR J 293 PRO J 294 0 0.80
CISPEP 10 ASP J 433 PRO J 434 0 -7.46
SITE 1 AC1 4 SER A 145 ARG A 146 GLY A 147 GLU A 212
SITE 1 AC2 3 THR B 34 ARG B 146 LYS B 248
SITE 1 AC3 3 PRO C 28 TYR C 314 LYS C 315
SITE 1 AC4 3 PRO D 28 TYR D 314 LYS D 315
SITE 1 AC5 4 ALA E 337 LYS E 376 SER E 377 SER E 394
SITE 1 AC6 2 ASN E 49 ARG E 263
SITE 1 AC7 6 ASN F 333 ALA F 337 LYS F 376 SER F 377
SITE 2 AC7 6 ILE F 378 SER F 394
SITE 1 AC8 2 SER F 261 ARG F 263
SITE 1 AC9 3 GLY G 159 SER G 160 TYR G 432
SITE 1 AD1 3 GLY H 159 SER H 160 ARG H 163
SITE 1 AD2 4 THR I 48 TYR I 53 GLU I 56 LEU I 301
SITE 1 AD3 5 THR J 48 TYR J 53 GLU J 56 LEU J 301
SITE 2 AD3 5 LEU J 302
CRYST1 155.578 207.712 155.744 90.00 96.96 90.00 P 1 21 1 4
ORIGX1 1.000000 0.000000 0.000000 0.00000
ORIGX2 0.000000 1.000000 0.000000 0.00000
ORIGX3 0.000000 0.000000 1.000000 0.00000
SCALE1 0.006428 0.000000 0.000785 0.00000
SCALE2 0.000000 0.004814 0.000000 0.00000
SCALE3 0.000000 0.000000 0.006468 0.00000
(ATOM LINES ARE NOT SHOWN.)
END
