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Database: PDB
Entry: 6K71
LinkDB: 6K71
Original site: 6K71 
HEADER    TRANSLATION                             05-JUN-19   6K71              
TITLE     EIF2 - EIF2B COMPLEX                                                  
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA;        
COMPND   3 CHAIN: A, B;                                                         
COMPND   4 SYNONYM: EIF-2B GDP-GTP EXCHANGE FACTOR SUBUNIT ALPHA;               
COMPND   5 ENGINEERED: YES;                                                     
COMPND   6 MOL_ID: 2;                                                           
COMPND   7 MOLECULE: TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA;         
COMPND   8 CHAIN: C, D;                                                         
COMPND   9 SYNONYM: S20I15,S20III15,EIF-2B GDP-GTP EXCHANGE FACTOR SUBUNIT BETA;
COMPND  10 ENGINEERED: YES;                                                     
COMPND  11 MOL_ID: 3;                                                           
COMPND  12 MOLECULE: TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA;        
COMPND  13 CHAIN: E, F;                                                         
COMPND  14 SYNONYM: EIF2BG,EIF-2B GDP-GTP EXCHANGE FACTOR SUBUNIT GAMMA;        
COMPND  15 ENGINEERED: YES;                                                     
COMPND  16 MOL_ID: 4;                                                           
COMPND  17 MOLECULE: TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT DELTA;        
COMPND  18 CHAIN: G, H;                                                         
COMPND  19 SYNONYM: EIF-2B GDP-GTP EXCHANGE FACTOR SUBUNIT DELTA;               
COMPND  20 ENGINEERED: YES;                                                     
COMPND  21 MOL_ID: 5;                                                           
COMPND  22 MOLECULE: TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON;      
COMPND  23 CHAIN: I, J;                                                         
COMPND  24 SYNONYM: EIF-2B GDP-GTP EXCHANGE FACTOR SUBUNIT EPSILON;             
COMPND  25 ENGINEERED: YES;                                                     
COMPND  26 MOL_ID: 6;                                                           
COMPND  27 MOLECULE: EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1;      
COMPND  28 CHAIN: K;                                                            
COMPND  29 SYNONYM: EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT ALPHA,   
COMPND  30 EIF-2ALPHA;                                                          
COMPND  31 ENGINEERED: YES;                                                     
COMPND  32 MOL_ID: 7;                                                           
COMPND  33 MOLECULE: EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 2;      
COMPND  34 CHAIN: M;                                                            
COMPND  35 SYNONYM: EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT BETA,EIF-
COMPND  36 2-BETA;                                                              
COMPND  37 ENGINEERED: YES;                                                     
COMPND  38 MOL_ID: 8;                                                           
COMPND  39 MOLECULE: EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3;      
COMPND  40 CHAIN: P;                                                            
COMPND  41 SYNONYM: EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT GAMMA X, 
COMPND  42 EIF-2GX;                                                             
COMPND  43 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   3 ORGANISM_COMMON: HUMAN;                                              
SOURCE   4 ORGANISM_TAXID: 9606;                                                
SOURCE   5 GENE: EIF2B1, EIF2BA;                                                
SOURCE   6 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE   8 MOL_ID: 2;                                                           
SOURCE   9 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  10 ORGANISM_COMMON: HUMAN;                                              
SOURCE  11 ORGANISM_TAXID: 9606;                                                
SOURCE  12 GENE: EIF2B2, EIF2BB;                                                
SOURCE  13 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  14 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE  15 MOL_ID: 3;                                                           
SOURCE  16 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  17 ORGANISM_COMMON: HUMAN;                                              
SOURCE  18 ORGANISM_TAXID: 9606;                                                
SOURCE  19 GENE: EIF2B3;                                                        
SOURCE  20 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  21 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE  22 MOL_ID: 4;                                                           
SOURCE  23 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  24 ORGANISM_COMMON: HUMAN;                                              
SOURCE  25 ORGANISM_TAXID: 9606;                                                
SOURCE  26 GENE: EIF2B4, EIF2BD;                                                
SOURCE  27 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  28 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE  29 MOL_ID: 5;                                                           
SOURCE  30 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  31 ORGANISM_COMMON: HUMAN;                                              
SOURCE  32 ORGANISM_TAXID: 9606;                                                
SOURCE  33 GENE: EIF2B5, EIF2BE;                                                
SOURCE  34 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  35 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE  36 MOL_ID: 6;                                                           
SOURCE  37 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  38 ORGANISM_COMMON: HUMAN;                                              
SOURCE  39 ORGANISM_TAXID: 9606;                                                
SOURCE  40 GENE: EIF2S1, EIF2A;                                                 
SOURCE  41 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  42 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE  43 MOL_ID: 7;                                                           
SOURCE  44 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  45 ORGANISM_COMMON: HUMAN;                                              
SOURCE  46 ORGANISM_TAXID: 9606;                                                
SOURCE  47 GENE: EIF2S2, EIF2B;                                                 
SOURCE  48 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  49 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE  50 MOL_ID: 8;                                                           
SOURCE  51 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  52 ORGANISM_COMMON: HUMAN;                                              
SOURCE  53 ORGANISM_TAXID: 9606;                                                
SOURCE  54 GENE: EIF2S3, EIF2G;                                                 
SOURCE  55 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  56 EXPRESSION_SYSTEM_TAXID: 562                                         
KEYWDS    TRANSLATION INITIATION, TRANSLATION                                   
EXPDTA    ELECTRON MICROSCOPY                                                   
AUTHOR    K.KASHIWAGI,T.YOKOYAMA,T.ITO                                          
REVDAT   2   06-NOV-19 6K71    1       CRYST1 SCALE                             
REVDAT   1   10-JUL-19 6K71    0                                                
SPRSDE     10-JUL-19 6K71      6JLW                                             
JRNL        AUTH   K.KASHIWAGI,T.YOKOYAMA,M.NISHIMOTO,M.TAKAHASHI,A.SAKAMOTO,   
JRNL        AUTH 2 M.YONEMOCHI,M.SHIROUZU,T.ITO                                 
JRNL        TITL   STRUCTURAL BASIS FOR EIF2B INHIBITION IN INTEGRATED STRESS   
JRNL        TITL 2 RESPONSE.                                                    
JRNL        REF    SCIENCE                       V. 364   495 2019              
JRNL        REFN                   ESSN 1095-9203                               
JRNL        PMID   31048492                                                     
JRNL        DOI    10.1126/SCIENCE.AAW4104                                      
REMARK   2                                                                      
REMARK   2 RESOLUTION.    4.30 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   SOFTWARE PACKAGES      : NULL                                      
REMARK   3   RECONSTRUCTION SCHEMA  : NULL                                      
REMARK   3                                                                      
REMARK   3 EM MAP-MODEL FITTING AND REFINEMENT                                  
REMARK   3   PDB ENTRY                    : NULL                                
REMARK   3   REFINEMENT SPACE             : NULL                                
REMARK   3   REFINEMENT PROTOCOL          : NULL                                
REMARK   3   REFINEMENT TARGET            : NULL                                
REMARK   3   OVERALL ANISOTROPIC B VALUE  : NULL                                
REMARK   3                                                                      
REMARK   3 FITTING PROCEDURE : NULL                                             
REMARK   3                                                                      
REMARK   3 EM IMAGE RECONSTRUCTION STATISTICS                                   
REMARK   3   NOMINAL PIXEL SIZE (ANGSTROMS)    : NULL                           
REMARK   3   ACTUAL PIXEL SIZE  (ANGSTROMS)    : NULL                           
REMARK   3   EFFECTIVE RESOLUTION (ANGSTROMS)  : 4.300                          
REMARK   3   NUMBER OF PARTICLES               : 82123                          
REMARK   3   CTF CORRECTION METHOD             : PHASE FLIPPING AND AMPLITUDE   
REMARK   3                                       CORRECTION                     
REMARK   3                                                                      
REMARK   3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL                    
REMARK   3                                                                      
REMARK   3 OTHER DETAILS: NULL                                                  
REMARK   4                                                                      
REMARK   4 6K71 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBJ ON 07-JUN-19.                  
REMARK 100 THE DEPOSITION ID IS D_1300012413.                                   
REMARK 245                                                                      
REMARK 245 EXPERIMENTAL DETAILS                                                 
REMARK 245   RECONSTRUCTION METHOD          : SINGLE PARTICLE                   
REMARK 245   SPECIMEN TYPE                  : NULL                              
REMARK 245                                                                      
REMARK 245 ELECTRON MICROSCOPE SAMPLE                                           
REMARK 245   SAMPLE TYPE                    : PARTICLE                          
REMARK 245   PARTICLE TYPE                  : POINT                             
REMARK 245   NAME OF SAMPLE                 : EIF2 - EIF2B COMPLEX              
REMARK 245   SAMPLE CONCENTRATION (MG ML-1) : NULL                              
REMARK 245   SAMPLE SUPPORT DETAILS         : NULL                              
REMARK 245   SAMPLE VITRIFICATION DETAILS   : NULL                              
REMARK 245   SAMPLE BUFFER                  : NULL                              
REMARK 245   PH                             : 7.50                              
REMARK 245   SAMPLE DETAILS                 : NULL                              
REMARK 245                                                                      
REMARK 245 DATA ACQUISITION                                                     
REMARK 245   DATE OF EXPERIMENT                : NULL                           
REMARK 245   NUMBER OF MICROGRAPHS-IMAGES      : NULL                           
REMARK 245   TEMPERATURE (KELVIN)              : NULL                           
REMARK 245   MICROSCOPE MODEL                  : FEI TECNAI ARCTICA             
REMARK 245   DETECTOR TYPE                     : GATAN K2 SUMMIT (4K X 4K)      
REMARK 245   MINIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MAXIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MINIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   MAXIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   NOMINAL CS                        : NULL                           
REMARK 245   IMAGING MODE                      : BRIGHT FIELD                   
REMARK 245   ELECTRON DOSE (ELECTRONS NM**-2)  : 50.00                          
REMARK 245   ILLUMINATION MODE                 : FLOOD BEAM                     
REMARK 245   NOMINAL MAGNIFICATION             : NULL                           
REMARK 245   CALIBRATED MAGNIFICATION          : NULL                           
REMARK 245   SOURCE                            : FIELD EMISSION GUN             
REMARK 245   ACCELERATION VOLTAGE (KV)         : 200                            
REMARK 245   IMAGING DETAILS                   : NULL                           
REMARK 247                                                                      
REMARK 247 ELECTRON MICROSCOPY                                                  
REMARK 247  THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON          
REMARK 247  MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE              
REMARK 247  THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES           
REMARK 247  ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION         
REMARK 247  OF THE STRUCTURE FACTORS.                                           
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TRIDECAMERIC                      
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E, F, G, H, I, J,         
REMARK 350                    AND CHAINS: K, M, P                               
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     MET A     1                                                      
REMARK 465     ASP A     2                                                      
REMARK 465     ASP A     3                                                      
REMARK 465     ASP A    37                                                      
REMARK 465     LYS A    38                                                      
REMARK 465     GLY A    39                                                      
REMARK 465     GLU A    40                                                      
REMARK 465     THR A    41                                                      
REMARK 465     ILE A    42                                                      
REMARK 465     GLN A    43                                                      
REMARK 465     LEU A    78                                                      
REMARK 465     ALA A    79                                                      
REMARK 465     SER A    80                                                      
REMARK 465     LEU A    81                                                      
REMARK 465     GLU A    82                                                      
REMARK 465     TYR A    83                                                      
REMARK 465     SER A    84                                                      
REMARK 465     ASP A    85                                                      
REMARK 465     TYR A    86                                                      
REMARK 465     SER A    87                                                      
REMARK 465     LYS A    88                                                      
REMARK 465     CYS A    89                                                      
REMARK 465     LYS A    90                                                      
REMARK 465     LYS A   253                                                      
REMARK 465     ALA A   254                                                      
REMARK 465     ASP A   255                                                      
REMARK 465     THR A   256                                                      
REMARK 465     LEU A   257                                                      
REMARK 465     LYS A   258                                                      
REMARK 465     VAL A   259                                                      
REMARK 465     ALA A   260                                                      
REMARK 465     GLN A   261                                                      
REMARK 465     THR A   262                                                      
REMARK 465     GLY A   263                                                      
REMARK 465     GLN A   264                                                      
REMARK 465     ASP A   265                                                      
REMARK 465     LEU A   266                                                      
REMARK 465     LYS A   267                                                      
REMARK 465     GLU A   268                                                      
REMARK 465     GLU A   269                                                      
REMARK 465     MET B     1                                                      
REMARK 465     ASP B     2                                                      
REMARK 465     ASP B     3                                                      
REMARK 465     ASP B    37                                                      
REMARK 465     LYS B    38                                                      
REMARK 465     GLY B    39                                                      
REMARK 465     GLU B    40                                                      
REMARK 465     THR B    41                                                      
REMARK 465     ILE B    42                                                      
REMARK 465     GLN B    43                                                      
REMARK 465     LEU B    78                                                      
REMARK 465     ALA B    79                                                      
REMARK 465     SER B    80                                                      
REMARK 465     LEU B    81                                                      
REMARK 465     GLU B    82                                                      
REMARK 465     TYR B    83                                                      
REMARK 465     SER B    84                                                      
REMARK 465     ASP B    85                                                      
REMARK 465     TYR B    86                                                      
REMARK 465     SER B    87                                                      
REMARK 465     LYS B    88                                                      
REMARK 465     CYS B    89                                                      
REMARK 465     LYS B    90                                                      
REMARK 465     LYS B   253                                                      
REMARK 465     ALA B   254                                                      
REMARK 465     ASP B   255                                                      
REMARK 465     THR B   256                                                      
REMARK 465     LEU B   257                                                      
REMARK 465     LYS B   258                                                      
REMARK 465     VAL B   259                                                      
REMARK 465     ALA B   260                                                      
REMARK 465     GLN B   261                                                      
REMARK 465     THR B   262                                                      
REMARK 465     GLY B   263                                                      
REMARK 465     GLN B   264                                                      
REMARK 465     ASP B   265                                                      
REMARK 465     LEU B   266                                                      
REMARK 465     LYS B   267                                                      
REMARK 465     GLU B   268                                                      
REMARK 465     GLU B   269                                                      
REMARK 465     MET C     1                                                      
REMARK 465     PRO C     2                                                      
REMARK 465     GLY C     3                                                      
REMARK 465     SER C     4                                                      
REMARK 465     ALA C     5                                                      
REMARK 465     ALA C     6                                                      
REMARK 465     LYS C     7                                                      
REMARK 465     ARG C    99                                                      
REMARK 465     SER C   100                                                      
REMARK 465     ASP C   101                                                      
REMARK 465     GLU C   102                                                      
REMARK 465     SER C   103                                                      
REMARK 465     ASP C   104                                                      
REMARK 465     GLN C   105                                                      
REMARK 465     GLN C   106                                                      
REMARK 465     GLU C   107                                                      
REMARK 465     SER C   108                                                      
REMARK 465     LEU C   109                                                      
REMARK 465     HIS C   110                                                      
REMARK 465     LYS C   111                                                      
REMARK 465     LEU C   112                                                      
REMARK 465     LEU C   113                                                      
REMARK 465     THR C   114                                                      
REMARK 465     SER C   115                                                      
REMARK 465     GLY C   116                                                      
REMARK 465     GLY C   117                                                      
REMARK 465     LEU C   118                                                      
REMARK 465     ASN C   119                                                      
REMARK 465     GLU C   120                                                      
REMARK 465     ASP C   121                                                      
REMARK 465     PHE C   122                                                      
REMARK 465     SER C   123                                                      
REMARK 465     PHE C   124                                                      
REMARK 465     MET D     1                                                      
REMARK 465     PRO D     2                                                      
REMARK 465     GLY D     3                                                      
REMARK 465     SER D     4                                                      
REMARK 465     ALA D     5                                                      
REMARK 465     ALA D     6                                                      
REMARK 465     LYS D     7                                                      
REMARK 465     ARG D    99                                                      
REMARK 465     SER D   100                                                      
REMARK 465     ASP D   101                                                      
REMARK 465     GLU D   102                                                      
REMARK 465     SER D   103                                                      
REMARK 465     ASP D   104                                                      
REMARK 465     GLN D   105                                                      
REMARK 465     GLN D   106                                                      
REMARK 465     GLU D   107                                                      
REMARK 465     SER D   108                                                      
REMARK 465     LEU D   109                                                      
REMARK 465     HIS D   110                                                      
REMARK 465     LYS D   111                                                      
REMARK 465     LEU D   112                                                      
REMARK 465     LEU D   113                                                      
REMARK 465     THR D   114                                                      
REMARK 465     SER D   115                                                      
REMARK 465     GLY D   116                                                      
REMARK 465     GLY D   117                                                      
REMARK 465     LEU D   118                                                      
REMARK 465     ASN D   119                                                      
REMARK 465     GLU D   120                                                      
REMARK 465     ASP D   121                                                      
REMARK 465     PHE D   122                                                      
REMARK 465     SER D   123                                                      
REMARK 465     PHE D   124                                                      
REMARK 465     GLY E    13                                                      
REMARK 465     SER E    14                                                      
REMARK 465     ARG E    15                                                      
REMARK 465     MET E    16                                                      
REMARK 465     THR E    17                                                      
REMARK 465     ASP E    18                                                      
REMARK 465     LEU E    19                                                      
REMARK 465     THR E    20                                                      
REMARK 465     SER E    21                                                      
REMARK 465     SER E    22                                                      
REMARK 465     ILE E    23                                                      
REMARK 465     PRO E    24                                                      
REMARK 465     LYS E    25                                                      
REMARK 465     ARG E    57                                                      
REMARK 465     ASP E    58                                                      
REMARK 465     VAL E    59                                                      
REMARK 465     GLN E    60                                                      
REMARK 465     GLY E   135                                                      
REMARK 465     GLN E   136                                                      
REMARK 465     ASP E   137                                                      
REMARK 465     SER E   138                                                      
REMARK 465     ILE E   139                                                      
REMARK 465     GLU E   140                                                      
REMARK 465     PRO E   141                                                      
REMARK 465     VAL E   142                                                      
REMARK 465     PRO E   143                                                      
REMARK 465     GLY E   144                                                      
REMARK 465     GLN E   145                                                      
REMARK 465     LYS E   146                                                      
REMARK 465     GLY E   147                                                      
REMARK 465     LYS E   148                                                      
REMARK 465     LYS E   149                                                      
REMARK 465     LYS E   150                                                      
REMARK 465     ALA E   151                                                      
REMARK 465     VAL E   152                                                      
REMARK 465     GLU E   153                                                      
REMARK 465     GLN E   154                                                      
REMARK 465     PHE E   237                                                      
REMARK 465     SER E   238                                                      
REMARK 465     GLN E   244                                                      
REMARK 465     GLY E   245                                                      
REMARK 465     GLN E   246                                                      
REMARK 465     GLU E   247                                                      
REMARK 465     GLU E   248                                                      
REMARK 465     LYS E   249                                                      
REMARK 465     GLU E   250                                                      
REMARK 465     GLU E   251                                                      
REMARK 465     ASP E   252                                                      
REMARK 465     LEU E   253                                                      
REMARK 465     LYS E   254                                                      
REMARK 465     LYS E   255                                                      
REMARK 465     LYS E   256                                                      
REMARK 465     GLU E   257                                                      
REMARK 465     LEU E   258                                                      
REMARK 465     LYS E   259                                                      
REMARK 465     LYS E   268                                                      
REMARK 465     GLU E   269                                                      
REMARK 465     ALA E   270                                                      
REMARK 465     ASN E   271                                                      
REMARK 465     LEU E   293                                                      
REMARK 465     SER E   294                                                      
REMARK 465     ARG E   295                                                      
REMARK 465     SER E   296                                                      
REMARK 465     GLN E   297                                                      
REMARK 465     VAL E   298                                                      
REMARK 465     ARG E   299                                                      
REMARK 465     CYS E   300                                                      
REMARK 465     TYR E   301                                                      
REMARK 465     VAL E   302                                                      
REMARK 465     HIS E   303                                                      
REMARK 465     ILE E   304                                                      
REMARK 465     MET E   305                                                      
REMARK 465     LYS E   306                                                      
REMARK 465     GLU E   307                                                      
REMARK 465     GLY E   308                                                      
REMARK 465     LEU E   309                                                      
REMARK 465     CYS E   310                                                      
REMARK 465     SER E   311                                                      
REMARK 465     ARG E   312                                                      
REMARK 465     VAL E   313                                                      
REMARK 465     SER E   314                                                      
REMARK 465     THR E   315                                                      
REMARK 465     LEU E   316                                                      
REMARK 465     GLY E   317                                                      
REMARK 465     LEU E   318                                                      
REMARK 465     TYR E   319                                                      
REMARK 465     MET E   320                                                      
REMARK 465     GLU E   321                                                      
REMARK 465     ALA E   322                                                      
REMARK 465     ASN E   323                                                      
REMARK 465     ARG E   324                                                      
REMARK 465     GLN E   325                                                      
REMARK 465     VAL E   326                                                      
REMARK 465     PRO E   327                                                      
REMARK 465     LYS E   328                                                      
REMARK 465     LEU E   329                                                      
REMARK 465     LEU E   330                                                      
REMARK 465     SER E   331                                                      
REMARK 465     ALA E   332                                                      
REMARK 465     LEU E   333                                                      
REMARK 465     CYS E   334                                                      
REMARK 465     PRO E   335                                                      
REMARK 465     GLU E   336                                                      
REMARK 465     GLU E   337                                                      
REMARK 465     PRO E   338                                                      
REMARK 465     PRO E   339                                                      
REMARK 465     VAL E   340                                                      
REMARK 465     HIS E   341                                                      
REMARK 465     GLY E   445                                                      
REMARK 465     ASN E   446                                                      
REMARK 465     ASP E   447                                                      
REMARK 465     GLN E   448                                                      
REMARK 465     LEU E   449                                                      
REMARK 465     MET E   450                                                      
REMARK 465     GLU E   451                                                      
REMARK 465     ILE E   452                                                      
REMARK 465     GLY F    13                                                      
REMARK 465     SER F    14                                                      
REMARK 465     ARG F    15                                                      
REMARK 465     MET F    16                                                      
REMARK 465     THR F    17                                                      
REMARK 465     ASP F    18                                                      
REMARK 465     LEU F    19                                                      
REMARK 465     THR F    20                                                      
REMARK 465     SER F    21                                                      
REMARK 465     SER F    22                                                      
REMARK 465     ILE F    23                                                      
REMARK 465     PRO F    24                                                      
REMARK 465     LYS F    25                                                      
REMARK 465     ARG F    57                                                      
REMARK 465     ASP F    58                                                      
REMARK 465     VAL F    59                                                      
REMARK 465     GLN F    60                                                      
REMARK 465     GLY F   135                                                      
REMARK 465     GLN F   136                                                      
REMARK 465     ASP F   137                                                      
REMARK 465     SER F   138                                                      
REMARK 465     ILE F   139                                                      
REMARK 465     GLU F   140                                                      
REMARK 465     PRO F   141                                                      
REMARK 465     VAL F   142                                                      
REMARK 465     PRO F   143                                                      
REMARK 465     GLY F   144                                                      
REMARK 465     GLN F   145                                                      
REMARK 465     LYS F   146                                                      
REMARK 465     GLY F   147                                                      
REMARK 465     LYS F   148                                                      
REMARK 465     LYS F   149                                                      
REMARK 465     LYS F   150                                                      
REMARK 465     ALA F   151                                                      
REMARK 465     VAL F   152                                                      
REMARK 465     GLU F   153                                                      
REMARK 465     GLN F   154                                                      
REMARK 465     PHE F   237                                                      
REMARK 465     SER F   238                                                      
REMARK 465     GLN F   244                                                      
REMARK 465     GLY F   245                                                      
REMARK 465     GLN F   246                                                      
REMARK 465     GLU F   247                                                      
REMARK 465     GLU F   248                                                      
REMARK 465     LYS F   249                                                      
REMARK 465     GLU F   250                                                      
REMARK 465     GLU F   251                                                      
REMARK 465     ASP F   252                                                      
REMARK 465     LEU F   253                                                      
REMARK 465     LYS F   254                                                      
REMARK 465     LYS F   255                                                      
REMARK 465     LYS F   256                                                      
REMARK 465     GLU F   257                                                      
REMARK 465     LEU F   258                                                      
REMARK 465     LYS F   259                                                      
REMARK 465     LYS F   268                                                      
REMARK 465     GLU F   269                                                      
REMARK 465     ALA F   270                                                      
REMARK 465     ASN F   271                                                      
REMARK 465     THR F   272                                                      
REMARK 465     LEU F   273                                                      
REMARK 465     ASN F   274                                                      
REMARK 465     LEU F   275                                                      
REMARK 465     LEU F   293                                                      
REMARK 465     SER F   294                                                      
REMARK 465     ARG F   295                                                      
REMARK 465     SER F   296                                                      
REMARK 465     GLN F   297                                                      
REMARK 465     VAL F   298                                                      
REMARK 465     ARG F   299                                                      
REMARK 465     CYS F   300                                                      
REMARK 465     TYR F   301                                                      
REMARK 465     VAL F   302                                                      
REMARK 465     HIS F   303                                                      
REMARK 465     ILE F   304                                                      
REMARK 465     MET F   305                                                      
REMARK 465     LYS F   306                                                      
REMARK 465     GLU F   307                                                      
REMARK 465     GLY F   308                                                      
REMARK 465     LEU F   309                                                      
REMARK 465     CYS F   310                                                      
REMARK 465     SER F   311                                                      
REMARK 465     ARG F   312                                                      
REMARK 465     VAL F   313                                                      
REMARK 465     SER F   314                                                      
REMARK 465     THR F   315                                                      
REMARK 465     LEU F   316                                                      
REMARK 465     GLY F   317                                                      
REMARK 465     LEU F   318                                                      
REMARK 465     TYR F   319                                                      
REMARK 465     MET F   320                                                      
REMARK 465     GLU F   321                                                      
REMARK 465     ALA F   322                                                      
REMARK 465     ASN F   323                                                      
REMARK 465     ARG F   324                                                      
REMARK 465     GLN F   325                                                      
REMARK 465     VAL F   326                                                      
REMARK 465     PRO F   327                                                      
REMARK 465     LYS F   328                                                      
REMARK 465     LEU F   329                                                      
REMARK 465     LEU F   330                                                      
REMARK 465     SER F   331                                                      
REMARK 465     ALA F   332                                                      
REMARK 465     LEU F   333                                                      
REMARK 465     CYS F   334                                                      
REMARK 465     PRO F   335                                                      
REMARK 465     GLU F   336                                                      
REMARK 465     GLU F   337                                                      
REMARK 465     PRO F   338                                                      
REMARK 465     PRO F   339                                                      
REMARK 465     VAL F   340                                                      
REMARK 465     HIS F   341                                                      
REMARK 465     GLY F   445                                                      
REMARK 465     ASN F   446                                                      
REMARK 465     ASP F   447                                                      
REMARK 465     GLN F   448                                                      
REMARK 465     LEU F   449                                                      
REMARK 465     MET F   450                                                      
REMARK 465     GLU F   451                                                      
REMARK 465     ILE F   452                                                      
REMARK 465     MET G     1                                                      
REMARK 465     ALA G     2                                                      
REMARK 465     ALA G     3                                                      
REMARK 465     VAL G     4                                                      
REMARK 465     ALA G     5                                                      
REMARK 465     VAL G     6                                                      
REMARK 465     ALA G     7                                                      
REMARK 465     VAL G     8                                                      
REMARK 465     ARG G     9                                                      
REMARK 465     GLU G    10                                                      
REMARK 465     ASP G    11                                                      
REMARK 465     SER G    12                                                      
REMARK 465     GLY G    13                                                      
REMARK 465     SER G    14                                                      
REMARK 465     GLY G    15                                                      
REMARK 465     MET G    16                                                      
REMARK 465     LYS G    17                                                      
REMARK 465     ALA G    18                                                      
REMARK 465     GLU G    19                                                      
REMARK 465     LEU G    20                                                      
REMARK 465     PRO G    21                                                      
REMARK 465     PRO G    22                                                      
REMARK 465     GLY G    23                                                      
REMARK 465     PRO G    24                                                      
REMARK 465     GLY G    25                                                      
REMARK 465     ALA G    26                                                      
REMARK 465     VAL G    27                                                      
REMARK 465     GLY G    28                                                      
REMARK 465     ARG G    29                                                      
REMARK 465     GLU G    30                                                      
REMARK 465     MET G    31                                                      
REMARK 465     THR G    32                                                      
REMARK 465     LYS G    33                                                      
REMARK 465     GLU G    34                                                      
REMARK 465     GLU G    35                                                      
REMARK 465     LYS G    36                                                      
REMARK 465     LEU G    37                                                      
REMARK 465     GLN G    38                                                      
REMARK 465     LEU G    39                                                      
REMARK 465     ARG G    40                                                      
REMARK 465     LYS G    41                                                      
REMARK 465     GLU G    42                                                      
REMARK 465     LYS G    43                                                      
REMARK 465     LYS G    44                                                      
REMARK 465     GLN G    45                                                      
REMARK 465     GLN G    46                                                      
REMARK 465     LYS G    47                                                      
REMARK 465     LYS G    48                                                      
REMARK 465     LYS G    49                                                      
REMARK 465     ARG G    50                                                      
REMARK 465     LYS G    51                                                      
REMARK 465     GLU G    52                                                      
REMARK 465     GLU G    53                                                      
REMARK 465     LYS G    54                                                      
REMARK 465     GLY G    55                                                      
REMARK 465     ALA G    56                                                      
REMARK 465     GLU G    57                                                      
REMARK 465     PRO G    58                                                      
REMARK 465     GLU G    59                                                      
REMARK 465     THR G    60                                                      
REMARK 465     GLY G    61                                                      
REMARK 465     SER G    62                                                      
REMARK 465     ALA G    63                                                      
REMARK 465     VAL G    64                                                      
REMARK 465     SER G    65                                                      
REMARK 465     ALA G    66                                                      
REMARK 465     ALA G    67                                                      
REMARK 465     GLN G    68                                                      
REMARK 465     CYS G    69                                                      
REMARK 465     GLN G    70                                                      
REMARK 465     VAL G    71                                                      
REMARK 465     GLY G    72                                                      
REMARK 465     PRO G    73                                                      
REMARK 465     THR G    74                                                      
REMARK 465     ARG G    75                                                      
REMARK 465     GLU G    76                                                      
REMARK 465     LEU G    77                                                      
REMARK 465     PRO G    78                                                      
REMARK 465     GLU G    79                                                      
REMARK 465     SER G    80                                                      
REMARK 465     GLY G    81                                                      
REMARK 465     ILE G    82                                                      
REMARK 465     GLN G    83                                                      
REMARK 465     LEU G    84                                                      
REMARK 465     GLY G    85                                                      
REMARK 465     THR G    86                                                      
REMARK 465     PRO G    87                                                      
REMARK 465     ARG G    88                                                      
REMARK 465     GLU G    89                                                      
REMARK 465     LYS G    90                                                      
REMARK 465     VAL G    91                                                      
REMARK 465     PRO G    92                                                      
REMARK 465     ALA G    93                                                      
REMARK 465     GLY G    94                                                      
REMARK 465     ARG G    95                                                      
REMARK 465     SER G    96                                                      
REMARK 465     LYS G    97                                                      
REMARK 465     ALA G    98                                                      
REMARK 465     GLU G    99                                                      
REMARK 465     LEU G   100                                                      
REMARK 465     ARG G   101                                                      
REMARK 465     ALA G   102                                                      
REMARK 465     GLU G   103                                                      
REMARK 465     ARG G   104                                                      
REMARK 465     ARG G   105                                                      
REMARK 465     ALA G   106                                                      
REMARK 465     LYS G   107                                                      
REMARK 465     GLN G   108                                                      
REMARK 465     GLU G   109                                                      
REMARK 465     ALA G   110                                                      
REMARK 465     GLU G   111                                                      
REMARK 465     ARG G   112                                                      
REMARK 465     ALA G   113                                                      
REMARK 465     LEU G   114                                                      
REMARK 465     LYS G   115                                                      
REMARK 465     GLN G   116                                                      
REMARK 465     ALA G   117                                                      
REMARK 465     ARG G   118                                                      
REMARK 465     LYS G   119                                                      
REMARK 465     GLY G   120                                                      
REMARK 465     GLU G   121                                                      
REMARK 465     GLN G   122                                                      
REMARK 465     GLY G   123                                                      
REMARK 465     GLY G   124                                                      
REMARK 465     PRO G   125                                                      
REMARK 465     PRO G   126                                                      
REMARK 465     PRO G   127                                                      
REMARK 465     LYS G   128                                                      
REMARK 465     ALA G   129                                                      
REMARK 465     SER G   130                                                      
REMARK 465     PRO G   131                                                      
REMARK 465     SER G   132                                                      
REMARK 465     THR G   133                                                      
REMARK 465     ALA G   134                                                      
REMARK 465     GLY G   135                                                      
REMARK 465     GLU G   136                                                      
REMARK 465     THR G   137                                                      
REMARK 465     PRO G   138                                                      
REMARK 465     SER G   139                                                      
REMARK 465     GLY G   140                                                      
REMARK 465     VAL G   141                                                      
REMARK 465     LYS G   142                                                      
REMARK 465     ARG G   143                                                      
REMARK 465     LEU G   144                                                      
REMARK 465     PRO G   145                                                      
REMARK 465     GLU G   146                                                      
REMARK 465     TYR G   147                                                      
REMARK 465     PRO G   148                                                      
REMARK 465     GLN G   149                                                      
REMARK 465     VAL G   150                                                      
REMARK 465     ASP G   151                                                      
REMARK 465     ASP G   152                                                      
REMARK 465     LEU G   153                                                      
REMARK 465     LEU G   154                                                      
REMARK 465     LEU G   155                                                      
REMARK 465     ARG G   156                                                      
REMARK 465     ARG G   157                                                      
REMARK 465     LEU G   158                                                      
REMARK 465     VAL G   159                                                      
REMARK 465     LYS G   160                                                      
REMARK 465     LYS G   161                                                      
REMARK 465     PRO G   162                                                      
REMARK 465     GLU G   163                                                      
REMARK 465     ARG G   164                                                      
REMARK 465     GLN G   165                                                      
REMARK 465     GLN G   523                                                      
REMARK 465     MET H     1                                                      
REMARK 465     ALA H     2                                                      
REMARK 465     ALA H     3                                                      
REMARK 465     VAL H     4                                                      
REMARK 465     ALA H     5                                                      
REMARK 465     VAL H     6                                                      
REMARK 465     ALA H     7                                                      
REMARK 465     VAL H     8                                                      
REMARK 465     ARG H     9                                                      
REMARK 465     GLU H    10                                                      
REMARK 465     ASP H    11                                                      
REMARK 465     SER H    12                                                      
REMARK 465     GLY H    13                                                      
REMARK 465     SER H    14                                                      
REMARK 465     GLY H    15                                                      
REMARK 465     MET H    16                                                      
REMARK 465     LYS H    17                                                      
REMARK 465     ALA H    18                                                      
REMARK 465     GLU H    19                                                      
REMARK 465     LEU H    20                                                      
REMARK 465     PRO H    21                                                      
REMARK 465     PRO H    22                                                      
REMARK 465     GLY H    23                                                      
REMARK 465     PRO H    24                                                      
REMARK 465     GLY H    25                                                      
REMARK 465     ALA H    26                                                      
REMARK 465     VAL H    27                                                      
REMARK 465     GLY H    28                                                      
REMARK 465     ARG H    29                                                      
REMARK 465     GLU H    30                                                      
REMARK 465     MET H    31                                                      
REMARK 465     THR H    32                                                      
REMARK 465     LYS H    33                                                      
REMARK 465     GLU H    34                                                      
REMARK 465     GLU H    35                                                      
REMARK 465     LYS H    36                                                      
REMARK 465     LEU H    37                                                      
REMARK 465     GLN H    38                                                      
REMARK 465     LEU H    39                                                      
REMARK 465     ARG H    40                                                      
REMARK 465     LYS H    41                                                      
REMARK 465     GLU H    42                                                      
REMARK 465     LYS H    43                                                      
REMARK 465     LYS H    44                                                      
REMARK 465     GLN H    45                                                      
REMARK 465     GLN H    46                                                      
REMARK 465     LYS H    47                                                      
REMARK 465     LYS H    48                                                      
REMARK 465     LYS H    49                                                      
REMARK 465     ARG H    50                                                      
REMARK 465     LYS H    51                                                      
REMARK 465     GLU H    52                                                      
REMARK 465     GLU H    53                                                      
REMARK 465     LYS H    54                                                      
REMARK 465     GLY H    55                                                      
REMARK 465     ALA H    56                                                      
REMARK 465     GLU H    57                                                      
REMARK 465     PRO H    58                                                      
REMARK 465     GLU H    59                                                      
REMARK 465     THR H    60                                                      
REMARK 465     GLY H    61                                                      
REMARK 465     SER H    62                                                      
REMARK 465     ALA H    63                                                      
REMARK 465     VAL H    64                                                      
REMARK 465     SER H    65                                                      
REMARK 465     ALA H    66                                                      
REMARK 465     ALA H    67                                                      
REMARK 465     GLN H    68                                                      
REMARK 465     CYS H    69                                                      
REMARK 465     GLN H    70                                                      
REMARK 465     VAL H    71                                                      
REMARK 465     GLY H    72                                                      
REMARK 465     PRO H    73                                                      
REMARK 465     THR H    74                                                      
REMARK 465     ARG H    75                                                      
REMARK 465     GLU H    76                                                      
REMARK 465     LEU H    77                                                      
REMARK 465     PRO H    78                                                      
REMARK 465     GLU H    79                                                      
REMARK 465     SER H    80                                                      
REMARK 465     GLY H    81                                                      
REMARK 465     ILE H    82                                                      
REMARK 465     GLN H    83                                                      
REMARK 465     LEU H    84                                                      
REMARK 465     GLY H    85                                                      
REMARK 465     THR H    86                                                      
REMARK 465     PRO H    87                                                      
REMARK 465     ARG H    88                                                      
REMARK 465     GLU H    89                                                      
REMARK 465     LYS H    90                                                      
REMARK 465     VAL H    91                                                      
REMARK 465     PRO H    92                                                      
REMARK 465     ALA H    93                                                      
REMARK 465     GLY H    94                                                      
REMARK 465     ARG H    95                                                      
REMARK 465     SER H    96                                                      
REMARK 465     LYS H    97                                                      
REMARK 465     ALA H    98                                                      
REMARK 465     GLU H    99                                                      
REMARK 465     LEU H   100                                                      
REMARK 465     ARG H   101                                                      
REMARK 465     ALA H   102                                                      
REMARK 465     GLU H   103                                                      
REMARK 465     ARG H   104                                                      
REMARK 465     ARG H   105                                                      
REMARK 465     ALA H   106                                                      
REMARK 465     LYS H   107                                                      
REMARK 465     GLN H   108                                                      
REMARK 465     GLU H   109                                                      
REMARK 465     ALA H   110                                                      
REMARK 465     GLU H   111                                                      
REMARK 465     ARG H   112                                                      
REMARK 465     ALA H   113                                                      
REMARK 465     LEU H   114                                                      
REMARK 465     LYS H   115                                                      
REMARK 465     GLN H   116                                                      
REMARK 465     ALA H   117                                                      
REMARK 465     ARG H   118                                                      
REMARK 465     LYS H   119                                                      
REMARK 465     GLY H   120                                                      
REMARK 465     GLU H   121                                                      
REMARK 465     GLN H   122                                                      
REMARK 465     GLY H   123                                                      
REMARK 465     GLY H   124                                                      
REMARK 465     PRO H   125                                                      
REMARK 465     PRO H   126                                                      
REMARK 465     PRO H   127                                                      
REMARK 465     LYS H   128                                                      
REMARK 465     ALA H   129                                                      
REMARK 465     SER H   130                                                      
REMARK 465     PRO H   131                                                      
REMARK 465     SER H   132                                                      
REMARK 465     THR H   133                                                      
REMARK 465     ALA H   134                                                      
REMARK 465     GLY H   135                                                      
REMARK 465     GLU H   136                                                      
REMARK 465     THR H   137                                                      
REMARK 465     PRO H   138                                                      
REMARK 465     SER H   139                                                      
REMARK 465     GLY H   140                                                      
REMARK 465     VAL H   141                                                      
REMARK 465     LYS H   142                                                      
REMARK 465     ARG H   143                                                      
REMARK 465     LEU H   144                                                      
REMARK 465     PRO H   145                                                      
REMARK 465     GLU H   146                                                      
REMARK 465     TYR H   147                                                      
REMARK 465     PRO H   148                                                      
REMARK 465     GLN H   149                                                      
REMARK 465     VAL H   150                                                      
REMARK 465     ASP H   151                                                      
REMARK 465     ASP H   152                                                      
REMARK 465     LEU H   153                                                      
REMARK 465     LEU H   154                                                      
REMARK 465     LEU H   155                                                      
REMARK 465     ARG H   156                                                      
REMARK 465     ARG H   157                                                      
REMARK 465     LEU H   158                                                      
REMARK 465     VAL H   159                                                      
REMARK 465     LYS H   160                                                      
REMARK 465     LYS H   161                                                      
REMARK 465     PRO H   162                                                      
REMARK 465     GLU H   163                                                      
REMARK 465     ARG H   164                                                      
REMARK 465     GLN H   165                                                      
REMARK 465     GLN H   523                                                      
REMARK 465     MET I     1                                                      
REMARK 465     ALA I     2                                                      
REMARK 465     ALA I     3                                                      
REMARK 465     PRO I     4                                                      
REMARK 465     VAL I     5                                                      
REMARK 465     VAL I     6                                                      
REMARK 465     ALA I     7                                                      
REMARK 465     PRO I     8                                                      
REMARK 465     PRO I     9                                                      
REMARK 465     GLY I    10                                                      
REMARK 465     VAL I    11                                                      
REMARK 465     VAL I    12                                                      
REMARK 465     VAL I    13                                                      
REMARK 465     SER I    14                                                      
REMARK 465     ARG I    15                                                      
REMARK 465     ALA I    16                                                      
REMARK 465     ASN I    17                                                      
REMARK 465     LYS I    18                                                      
REMARK 465     ARG I    19                                                      
REMARK 465     SER I    20                                                      
REMARK 465     GLY I    21                                                      
REMARK 465     ALA I    22                                                      
REMARK 465     GLY I    23                                                      
REMARK 465     PRO I    24                                                      
REMARK 465     GLY I    25                                                      
REMARK 465     GLY I    26                                                      
REMARK 465     SER I    27                                                      
REMARK 465     GLY I    28                                                      
REMARK 465     GLY I    29                                                      
REMARK 465     GLY I    30                                                      
REMARK 465     GLY I    31                                                      
REMARK 465     ALA I    32                                                      
REMARK 465     ARG I    33                                                      
REMARK 465     GLY I    34                                                      
REMARK 465     ALA I    35                                                      
REMARK 465     GLU I    36                                                      
REMARK 465     GLU I    37                                                      
REMARK 465     GLU I    38                                                      
REMARK 465     PRO I    39                                                      
REMARK 465     PRO I    40                                                      
REMARK 465     GLU I   280                                                      
REMARK 465     GLU I   281                                                      
REMARK 465     ILE I   282                                                      
REMARK 465     LEU I   283                                                      
REMARK 465     GLY I   284                                                      
REMARK 465     ASP I   467                                                      
REMARK 465     ASP I   468                                                      
REMARK 465     SER I   469                                                      
REMARK 465     GLY I   470                                                      
REMARK 465     ALA I   471                                                      
REMARK 465     ASP I   472                                                      
REMARK 465     GLN I   473                                                      
REMARK 465     GLU I   474                                                      
REMARK 465     LYS I   475                                                      
REMARK 465     ASP I   476                                                      
REMARK 465     LYS I   477                                                      
REMARK 465     VAL I   478                                                      
REMARK 465     LYS I   479                                                      
REMARK 465     MET I   480                                                      
REMARK 465     LYS I   481                                                      
REMARK 465     GLY I   482                                                      
REMARK 465     TYR I   483                                                      
REMARK 465     ASN I   484                                                      
REMARK 465     PRO I   485                                                      
REMARK 465     ALA I   486                                                      
REMARK 465     GLU I   487                                                      
REMARK 465     VAL I   488                                                      
REMARK 465     GLY I   489                                                      
REMARK 465     ALA I   490                                                      
REMARK 465     ALA I   491                                                      
REMARK 465     GLY I   492                                                      
REMARK 465     LYS I   493                                                      
REMARK 465     GLY I   494                                                      
REMARK 465     TYR I   495                                                      
REMARK 465     LEU I   496                                                      
REMARK 465     TRP I   497                                                      
REMARK 465     LYS I   498                                                      
REMARK 465     ALA I   499                                                      
REMARK 465     ALA I   500                                                      
REMARK 465     GLY I   501                                                      
REMARK 465     MET I   502                                                      
REMARK 465     ASN I   503                                                      
REMARK 465     MET I   504                                                      
REMARK 465     GLU I   505                                                      
REMARK 465     GLU I   506                                                      
REMARK 465     GLU I   507                                                      
REMARK 465     GLU I   508                                                      
REMARK 465     GLU I   509                                                      
REMARK 465     LEU I   510                                                      
REMARK 465     GLN I   511                                                      
REMARK 465     GLN I   512                                                      
REMARK 465     ASN I   513                                                      
REMARK 465     LEU I   514                                                      
REMARK 465     TRP I   515                                                      
REMARK 465     GLY I   516                                                      
REMARK 465     LEU I   517                                                      
REMARK 465     LYS I   518                                                      
REMARK 465     ILE I   519                                                      
REMARK 465     ASN I   520                                                      
REMARK 465     MET I   521                                                      
REMARK 465     GLU I   522                                                      
REMARK 465     GLU I   523                                                      
REMARK 465     GLU I   524                                                      
REMARK 465     SER I   525                                                      
REMARK 465     GLU I   526                                                      
REMARK 465     SER I   527                                                      
REMARK 465     GLU I   528                                                      
REMARK 465     SER I   529                                                      
REMARK 465     GLU I   530                                                      
REMARK 465     GLN I   531                                                      
REMARK 465     SER I   532                                                      
REMARK 465     MET I   533                                                      
REMARK 465     ASP I   534                                                      
REMARK 465     SER I   535                                                      
REMARK 465     GLU I   536                                                      
REMARK 465     GLU I   537                                                      
REMARK 465     PRO I   538                                                      
REMARK 465     ASP I   539                                                      
REMARK 465     SER I   540                                                      
REMARK 465     ARG I   541                                                      
REMARK 465     GLY I   542                                                      
REMARK 465     GLY I   543                                                      
REMARK 465     SER I   544                                                      
REMARK 465     PRO I   545                                                      
REMARK 465     GLN I   546                                                      
REMARK 465     MET I   547                                                      
REMARK 465     ASP I   548                                                      
REMARK 465     ASP I   549                                                      
REMARK 465     ILE I   550                                                      
REMARK 465     LYS I   551                                                      
REMARK 465     VAL I   552                                                      
REMARK 465     PHE I   553                                                      
REMARK 465     GLN I   554                                                      
REMARK 465     ASN I   555                                                      
REMARK 465     GLU I   556                                                      
REMARK 465     VAL I   557                                                      
REMARK 465     LEU I   558                                                      
REMARK 465     GLY I   559                                                      
REMARK 465     THR I   560                                                      
REMARK 465     LEU I   561                                                      
REMARK 465     GLN I   562                                                      
REMARK 465     ARG I   563                                                      
REMARK 465     GLY I   564                                                      
REMARK 465     LYS I   565                                                      
REMARK 465     GLU I   566                                                      
REMARK 465     GLU I   567                                                      
REMARK 465     ASN I   568                                                      
REMARK 465     ILE I   569                                                      
REMARK 465     SER I   570                                                      
REMARK 465     CYS I   571                                                      
REMARK 465     ASP I   572                                                      
REMARK 465     ASN I   573                                                      
REMARK 465     LEU I   574                                                      
REMARK 465     VAL I   575                                                      
REMARK 465     LEU I   576                                                      
REMARK 465     GLU I   577                                                      
REMARK 465     ILE I   578                                                      
REMARK 465     ASN I   579                                                      
REMARK 465     SER I   580                                                      
REMARK 465     LEU I   581                                                      
REMARK 465     LYS I   582                                                      
REMARK 465     TYR I   583                                                      
REMARK 465     ALA I   584                                                      
REMARK 465     TYR I   585                                                      
REMARK 465     ASN I   586                                                      
REMARK 465     ILE I   587                                                      
REMARK 465     SER I   588                                                      
REMARK 465     LEU I   589                                                      
REMARK 465     LYS I   590                                                      
REMARK 465     GLU I   591                                                      
REMARK 465     VAL I   592                                                      
REMARK 465     MET I   593                                                      
REMARK 465     GLN I   594                                                      
REMARK 465     VAL I   595                                                      
REMARK 465     LEU I   596                                                      
REMARK 465     SER I   597                                                      
REMARK 465     HIS I   598                                                      
REMARK 465     VAL I   599                                                      
REMARK 465     VAL I   600                                                      
REMARK 465     LEU I   601                                                      
REMARK 465     GLU I   602                                                      
REMARK 465     PHE I   603                                                      
REMARK 465     PRO I   604                                                      
REMARK 465     LEU I   605                                                      
REMARK 465     GLN I   606                                                      
REMARK 465     GLN I   607                                                      
REMARK 465     MET I   608                                                      
REMARK 465     ASP I   609                                                      
REMARK 465     SER I   610                                                      
REMARK 465     PRO I   611                                                      
REMARK 465     LEU I   612                                                      
REMARK 465     ASP I   613                                                      
REMARK 465     SER I   614                                                      
REMARK 465     SER I   615                                                      
REMARK 465     ARG I   616                                                      
REMARK 465     TYR I   617                                                      
REMARK 465     CYS I   618                                                      
REMARK 465     ALA I   619                                                      
REMARK 465     LEU I   620                                                      
REMARK 465     LEU I   621                                                      
REMARK 465     LEU I   622                                                      
REMARK 465     PRO I   623                                                      
REMARK 465     LEU I   624                                                      
REMARK 465     LEU I   625                                                      
REMARK 465     LYS I   626                                                      
REMARK 465     ALA I   627                                                      
REMARK 465     TRP I   628                                                      
REMARK 465     SER I   629                                                      
REMARK 465     PRO I   630                                                      
REMARK 465     VAL I   631                                                      
REMARK 465     PHE I   632                                                      
REMARK 465     ARG I   633                                                      
REMARK 465     ASN I   634                                                      
REMARK 465     TYR I   635                                                      
REMARK 465     ILE I   636                                                      
REMARK 465     LYS I   637                                                      
REMARK 465     ARG I   638                                                      
REMARK 465     ALA I   639                                                      
REMARK 465     ALA I   640                                                      
REMARK 465     ASP I   641                                                      
REMARK 465     HIS I   642                                                      
REMARK 465     LEU I   643                                                      
REMARK 465     GLU I   644                                                      
REMARK 465     ALA I   645                                                      
REMARK 465     LEU I   646                                                      
REMARK 465     ALA I   647                                                      
REMARK 465     ALA I   648                                                      
REMARK 465     ILE I   649                                                      
REMARK 465     GLU I   650                                                      
REMARK 465     ASP I   651                                                      
REMARK 465     PHE I   652                                                      
REMARK 465     PHE I   653                                                      
REMARK 465     LEU I   654                                                      
REMARK 465     GLU I   655                                                      
REMARK 465     HIS I   656                                                      
REMARK 465     GLU I   657                                                      
REMARK 465     ALA I   658                                                      
REMARK 465     LEU I   659                                                      
REMARK 465     GLY I   660                                                      
REMARK 465     ILE I   661                                                      
REMARK 465     SER I   662                                                      
REMARK 465     MET I   663                                                      
REMARK 465     ALA I   664                                                      
REMARK 465     LYS I   665                                                      
REMARK 465     VAL I   666                                                      
REMARK 465     LEU I   667                                                      
REMARK 465     MET I   668                                                      
REMARK 465     ALA I   669                                                      
REMARK 465     PHE I   670                                                      
REMARK 465     TYR I   671                                                      
REMARK 465     GLN I   672                                                      
REMARK 465     LEU I   673                                                      
REMARK 465     GLU I   674                                                      
REMARK 465     ILE I   675                                                      
REMARK 465     LEU I   676                                                      
REMARK 465     ALA I   677                                                      
REMARK 465     GLU I   678                                                      
REMARK 465     GLU I   679                                                      
REMARK 465     THR I   680                                                      
REMARK 465     ILE I   681                                                      
REMARK 465     LEU I   682                                                      
REMARK 465     SER I   683                                                      
REMARK 465     TRP I   684                                                      
REMARK 465     PHE I   685                                                      
REMARK 465     SER I   686                                                      
REMARK 465     GLN I   687                                                      
REMARK 465     ARG I   688                                                      
REMARK 465     ASP I   689                                                      
REMARK 465     THR I   690                                                      
REMARK 465     THR I   691                                                      
REMARK 465     ASP I   692                                                      
REMARK 465     LYS I   693                                                      
REMARK 465     GLY I   694                                                      
REMARK 465     GLN I   695                                                      
REMARK 465     GLN I   696                                                      
REMARK 465     LEU I   697                                                      
REMARK 465     ARG I   698                                                      
REMARK 465     LYS I   699                                                      
REMARK 465     ASN I   700                                                      
REMARK 465     GLN I   701                                                      
REMARK 465     GLN I   702                                                      
REMARK 465     LEU I   703                                                      
REMARK 465     GLN I   704                                                      
REMARK 465     ARG I   705                                                      
REMARK 465     PHE I   706                                                      
REMARK 465     ILE I   707                                                      
REMARK 465     GLN I   708                                                      
REMARK 465     TRP I   709                                                      
REMARK 465     LEU I   710                                                      
REMARK 465     LYS I   711                                                      
REMARK 465     GLU I   712                                                      
REMARK 465     ALA I   713                                                      
REMARK 465     GLU I   714                                                      
REMARK 465     GLU I   715                                                      
REMARK 465     GLU I   716                                                      
REMARK 465     SER I   717                                                      
REMARK 465     SER I   718                                                      
REMARK 465     GLU I   719                                                      
REMARK 465     ASP I   720                                                      
REMARK 465     ASP I   721                                                      
REMARK 465     MET J     1                                                      
REMARK 465     ALA J     2                                                      
REMARK 465     ALA J     3                                                      
REMARK 465     PRO J     4                                                      
REMARK 465     VAL J     5                                                      
REMARK 465     VAL J     6                                                      
REMARK 465     ALA J     7                                                      
REMARK 465     PRO J     8                                                      
REMARK 465     PRO J     9                                                      
REMARK 465     GLY J    10                                                      
REMARK 465     VAL J    11                                                      
REMARK 465     VAL J    12                                                      
REMARK 465     VAL J    13                                                      
REMARK 465     SER J    14                                                      
REMARK 465     ARG J    15                                                      
REMARK 465     ALA J    16                                                      
REMARK 465     ASN J    17                                                      
REMARK 465     LYS J    18                                                      
REMARK 465     ARG J    19                                                      
REMARK 465     SER J    20                                                      
REMARK 465     GLY J    21                                                      
REMARK 465     ALA J    22                                                      
REMARK 465     GLY J    23                                                      
REMARK 465     PRO J    24                                                      
REMARK 465     GLY J    25                                                      
REMARK 465     GLY J    26                                                      
REMARK 465     SER J    27                                                      
REMARK 465     GLY J    28                                                      
REMARK 465     GLY J    29                                                      
REMARK 465     GLY J    30                                                      
REMARK 465     GLY J    31                                                      
REMARK 465     ALA J    32                                                      
REMARK 465     ARG J    33                                                      
REMARK 465     GLY J    34                                                      
REMARK 465     ALA J    35                                                      
REMARK 465     GLU J    36                                                      
REMARK 465     GLU J    37                                                      
REMARK 465     GLU J    38                                                      
REMARK 465     PRO J    39                                                      
REMARK 465     PRO J    40                                                      
REMARK 465     GLU J   280                                                      
REMARK 465     GLU J   281                                                      
REMARK 465     ILE J   282                                                      
REMARK 465     LEU J   283                                                      
REMARK 465     GLY J   284                                                      
REMARK 465     ASP J   467                                                      
REMARK 465     ASP J   468                                                      
REMARK 465     SER J   469                                                      
REMARK 465     GLY J   470                                                      
REMARK 465     ALA J   471                                                      
REMARK 465     ASP J   472                                                      
REMARK 465     GLN J   473                                                      
REMARK 465     GLU J   474                                                      
REMARK 465     LYS J   475                                                      
REMARK 465     ASP J   476                                                      
REMARK 465     LYS J   477                                                      
REMARK 465     VAL J   478                                                      
REMARK 465     LYS J   479                                                      
REMARK 465     MET J   480                                                      
REMARK 465     LYS J   481                                                      
REMARK 465     GLY J   482                                                      
REMARK 465     TYR J   483                                                      
REMARK 465     ASN J   484                                                      
REMARK 465     PRO J   485                                                      
REMARK 465     ALA J   486                                                      
REMARK 465     GLU J   487                                                      
REMARK 465     VAL J   488                                                      
REMARK 465     GLY J   489                                                      
REMARK 465     ALA J   490                                                      
REMARK 465     ALA J   491                                                      
REMARK 465     GLY J   492                                                      
REMARK 465     LYS J   493                                                      
REMARK 465     GLY J   494                                                      
REMARK 465     TYR J   495                                                      
REMARK 465     LEU J   496                                                      
REMARK 465     TRP J   497                                                      
REMARK 465     LYS J   498                                                      
REMARK 465     ALA J   499                                                      
REMARK 465     ALA J   500                                                      
REMARK 465     GLY J   501                                                      
REMARK 465     MET J   502                                                      
REMARK 465     ASN J   503                                                      
REMARK 465     MET J   504                                                      
REMARK 465     GLU J   505                                                      
REMARK 465     GLU J   506                                                      
REMARK 465     GLU J   507                                                      
REMARK 465     GLU J   508                                                      
REMARK 465     GLU J   509                                                      
REMARK 465     LEU J   510                                                      
REMARK 465     GLN J   511                                                      
REMARK 465     GLN J   512                                                      
REMARK 465     ASN J   513                                                      
REMARK 465     LEU J   514                                                      
REMARK 465     TRP J   515                                                      
REMARK 465     GLY J   516                                                      
REMARK 465     LEU J   517                                                      
REMARK 465     LYS J   518                                                      
REMARK 465     ILE J   519                                                      
REMARK 465     ASN J   520                                                      
REMARK 465     MET J   521                                                      
REMARK 465     GLU J   522                                                      
REMARK 465     GLU J   523                                                      
REMARK 465     GLU J   524                                                      
REMARK 465     SER J   525                                                      
REMARK 465     GLU J   526                                                      
REMARK 465     SER J   527                                                      
REMARK 465     GLU J   528                                                      
REMARK 465     SER J   529                                                      
REMARK 465     GLU J   530                                                      
REMARK 465     GLN J   531                                                      
REMARK 465     SER J   532                                                      
REMARK 465     MET J   533                                                      
REMARK 465     ASP J   534                                                      
REMARK 465     SER J   535                                                      
REMARK 465     GLU J   536                                                      
REMARK 465     GLU J   537                                                      
REMARK 465     PRO J   538                                                      
REMARK 465     ASP J   539                                                      
REMARK 465     SER J   540                                                      
REMARK 465     ARG J   541                                                      
REMARK 465     GLY J   542                                                      
REMARK 465     GLY J   543                                                      
REMARK 465     SER J   544                                                      
REMARK 465     PRO J   545                                                      
REMARK 465     GLN J   546                                                      
REMARK 465     THR J   690                                                      
REMARK 465     THR J   691                                                      
REMARK 465     GLU J   716                                                      
REMARK 465     SER J   717                                                      
REMARK 465     SER J   718                                                      
REMARK 465     GLU J   719                                                      
REMARK 465     ASP J   720                                                      
REMARK 465     ASP J   721                                                      
REMARK 465     MET K     1                                                      
REMARK 465     PRO K     2                                                      
REMARK 465     GLY K     3                                                      
REMARK 465     LEU K     4                                                      
REMARK 465     SER K     5                                                      
REMARK 465     CYS K     6                                                      
REMARK 465     GLN K   272                                                      
REMARK 465     MET K   273                                                      
REMARK 465     GLU K   274                                                      
REMARK 465     PRO K   275                                                      
REMARK 465     LYS K   276                                                      
REMARK 465     VAL K   277                                                      
REMARK 465     VAL K   278                                                      
REMARK 465     THR K   279                                                      
REMARK 465     ASP K   280                                                      
REMARK 465     THR K   281                                                      
REMARK 465     ASP K   282                                                      
REMARK 465     GLU K   283                                                      
REMARK 465     THR K   284                                                      
REMARK 465     GLU K   285                                                      
REMARK 465     LEU K   286                                                      
REMARK 465     ALA K   287                                                      
REMARK 465     ARG K   288                                                      
REMARK 465     GLN K   289                                                      
REMARK 465     MET K   290                                                      
REMARK 465     GLU K   291                                                      
REMARK 465     ARG K   292                                                      
REMARK 465     LEU K   293                                                      
REMARK 465     GLU K   294                                                      
REMARK 465     ARG K   295                                                      
REMARK 465     GLU K   296                                                      
REMARK 465     ASN K   297                                                      
REMARK 465     ALA K   298                                                      
REMARK 465     GLU K   299                                                      
REMARK 465     VAL K   300                                                      
REMARK 465     ASP K   301                                                      
REMARK 465     GLY K   302                                                      
REMARK 465     ASP K   303                                                      
REMARK 465     ASP K   304                                                      
REMARK 465     ASP K   305                                                      
REMARK 465     ALA K   306                                                      
REMARK 465     GLU K   307                                                      
REMARK 465     GLU K   308                                                      
REMARK 465     MET K   309                                                      
REMARK 465     GLU K   310                                                      
REMARK 465     ALA K   311                                                      
REMARK 465     LYS K   312                                                      
REMARK 465     ALA K   313                                                      
REMARK 465     GLU K   314                                                      
REMARK 465     ASP K   315                                                      
REMARK 465     MET M     1                                                      
REMARK 465     SER M     2                                                      
REMARK 465     GLY M     3                                                      
REMARK 465     ASP M     4                                                      
REMARK 465     GLU M     5                                                      
REMARK 465     MET M     6                                                      
REMARK 465     ILE M     7                                                      
REMARK 465     PHE M     8                                                      
REMARK 465     ASP M     9                                                      
REMARK 465     PRO M    10                                                      
REMARK 465     THR M    11                                                      
REMARK 465     MET M    12                                                      
REMARK 465     SER M    13                                                      
REMARK 465     LYS M    14                                                      
REMARK 465     LYS M    15                                                      
REMARK 465     LYS M    16                                                      
REMARK 465     LYS M    17                                                      
REMARK 465     LYS M    18                                                      
REMARK 465     LYS M    19                                                      
REMARK 465     LYS M    20                                                      
REMARK 465     LYS M    21                                                      
REMARK 465     PRO M    22                                                      
REMARK 465     PHE M    23                                                      
REMARK 465     MET M    24                                                      
REMARK 465     LEU M    25                                                      
REMARK 465     ASP M    26                                                      
REMARK 465     GLU M    27                                                      
REMARK 465     GLU M    28                                                      
REMARK 465     GLY M    29                                                      
REMARK 465     ASP M    30                                                      
REMARK 465     THR M    31                                                      
REMARK 465     GLN M    32                                                      
REMARK 465     THR M    33                                                      
REMARK 465     GLU M    34                                                      
REMARK 465     GLU M    35                                                      
REMARK 465     THR M    36                                                      
REMARK 465     GLN M    37                                                      
REMARK 465     PRO M    38                                                      
REMARK 465     SER M    39                                                      
REMARK 465     GLU M    40                                                      
REMARK 465     THR M    41                                                      
REMARK 465     LYS M    42                                                      
REMARK 465     GLU M    43                                                      
REMARK 465     VAL M    44                                                      
REMARK 465     GLU M    45                                                      
REMARK 465     PRO M    46                                                      
REMARK 465     GLU M    47                                                      
REMARK 465     PRO M    48                                                      
REMARK 465     THR M    49                                                      
REMARK 465     GLU M    50                                                      
REMARK 465     ASP M    51                                                      
REMARK 465     LYS M    52                                                      
REMARK 465     ASP M    53                                                      
REMARK 465     LEU M    54                                                      
REMARK 465     GLU M    55                                                      
REMARK 465     ALA M    56                                                      
REMARK 465     ASP M    57                                                      
REMARK 465     GLU M    58                                                      
REMARK 465     GLU M    59                                                      
REMARK 465     ASP M    60                                                      
REMARK 465     THR M    61                                                      
REMARK 465     ARG M    62                                                      
REMARK 465     LYS M    63                                                      
REMARK 465     LYS M    64                                                      
REMARK 465     ASP M    65                                                      
REMARK 465     ALA M    66                                                      
REMARK 465     SER M    67                                                      
REMARK 465     ASP M    68                                                      
REMARK 465     ASP M    69                                                      
REMARK 465     LEU M    70                                                      
REMARK 465     ASP M    71                                                      
REMARK 465     ASP M    72                                                      
REMARK 465     LEU M    73                                                      
REMARK 465     ASN M    74                                                      
REMARK 465     PHE M    75                                                      
REMARK 465     PHE M    76                                                      
REMARK 465     ASN M    77                                                      
REMARK 465     GLN M    78                                                      
REMARK 465     LYS M    79                                                      
REMARK 465     LYS M    80                                                      
REMARK 465     LYS M    81                                                      
REMARK 465     LYS M    82                                                      
REMARK 465     LYS M    83                                                      
REMARK 465     LYS M    84                                                      
REMARK 465     THR M    85                                                      
REMARK 465     LYS M    86                                                      
REMARK 465     LYS M    87                                                      
REMARK 465     ILE M    88                                                      
REMARK 465     PHE M    89                                                      
REMARK 465     ASP M    90                                                      
REMARK 465     ILE M    91                                                      
REMARK 465     ASP M    92                                                      
REMARK 465     GLU M    93                                                      
REMARK 465     ALA M    94                                                      
REMARK 465     GLU M    95                                                      
REMARK 465     GLU M    96                                                      
REMARK 465     GLY M    97                                                      
REMARK 465     VAL M    98                                                      
REMARK 465     LYS M    99                                                      
REMARK 465     ASP M   100                                                      
REMARK 465     LEU M   101                                                      
REMARK 465     LYS M   102                                                      
REMARK 465     ILE M   103                                                      
REMARK 465     GLU M   104                                                      
REMARK 465     SER M   105                                                      
REMARK 465     ASP M   106                                                      
REMARK 465     VAL M   107                                                      
REMARK 465     GLN M   108                                                      
REMARK 465     GLU M   109                                                      
REMARK 465     PRO M   110                                                      
REMARK 465     THR M   111                                                      
REMARK 465     GLU M   112                                                      
REMARK 465     PRO M   113                                                      
REMARK 465     GLU M   114                                                      
REMARK 465     ASP M   115                                                      
REMARK 465     ASP M   116                                                      
REMARK 465     LEU M   117                                                      
REMARK 465     ASP M   118                                                      
REMARK 465     ILE M   119                                                      
REMARK 465     MET M   120                                                      
REMARK 465     LEU M   121                                                      
REMARK 465     GLY M   122                                                      
REMARK 465     ASN M   123                                                      
REMARK 465     LYS M   124                                                      
REMARK 465     LYS M   125                                                      
REMARK 465     LYS M   126                                                      
REMARK 465     LYS M   127                                                      
REMARK 465     LYS M   128                                                      
REMARK 465     LYS M   129                                                      
REMARK 465     ASN M   130                                                      
REMARK 465     VAL M   131                                                      
REMARK 465     LYS M   132                                                      
REMARK 465     PHE M   133                                                      
REMARK 465     PRO M   134                                                      
REMARK 465     ASP M   135                                                      
REMARK 465     GLU M   136                                                      
REMARK 465     ASP M   137                                                      
REMARK 465     GLU M   138                                                      
REMARK 465     ILE M   139                                                      
REMARK 465     LEU M   140                                                      
REMARK 465     GLU M   141                                                      
REMARK 465     LYS M   142                                                      
REMARK 465     ASP M   143                                                      
REMARK 465     GLU M   144                                                      
REMARK 465     ALA M   145                                                      
REMARK 465     LEU M   146                                                      
REMARK 465     GLU M   147                                                      
REMARK 465     ASP M   148                                                      
REMARK 465     GLU M   149                                                      
REMARK 465     ASP M   150                                                      
REMARK 465     ASN M   151                                                      
REMARK 465     LYS M   152                                                      
REMARK 465     LYS M   153                                                      
REMARK 465     ASP M   154                                                      
REMARK 465     ASP M   155                                                      
REMARK 465     GLY M   156                                                      
REMARK 465     ILE M   157                                                      
REMARK 465     SER M   158                                                      
REMARK 465     PHE M   159                                                      
REMARK 465     SER M   160                                                      
REMARK 465     ASN M   161                                                      
REMARK 465     GLN M   162                                                      
REMARK 465     THR M   163                                                      
REMARK 465     GLY M   164                                                      
REMARK 465     PRO M   165                                                      
REMARK 465     ALA M   166                                                      
REMARK 465     TRP M   167                                                      
REMARK 465     ALA M   168                                                      
REMARK 465     GLY M   169                                                      
REMARK 465     SER M   170                                                      
REMARK 465     GLU M   171                                                      
REMARK 465     ARG M   172                                                      
REMARK 465     GLU M   189                                                      
REMARK 465     LYS M   190                                                      
REMARK 465     ASN M   191                                                      
REMARK 465     PRO M   192                                                      
REMARK 465     ASP M   193                                                      
REMARK 465     MET M   194                                                      
REMARK 465     VAL M   195                                                      
REMARK 465     ALA M   196                                                      
REMARK 465     GLY M   197                                                      
REMARK 465     GLU M   198                                                      
REMARK 465     LYS M   199                                                      
REMARK 465     ARG M   200                                                      
REMARK 465     LYS M   201                                                      
REMARK 465     PHE M   202                                                      
REMARK 465     VAL M   203                                                      
REMARK 465     MET M   204                                                      
REMARK 465     LYS M   205                                                      
REMARK 465     PRO M   206                                                      
REMARK 465     PRO M   207                                                      
REMARK 465     GLN M   208                                                      
REMARK 465     VAL M   209                                                      
REMARK 465     VAL M   210                                                      
REMARK 465     ARG M   211                                                      
REMARK 465     VAL M   212                                                      
REMARK 465     GLY M   213                                                      
REMARK 465     THR M   214                                                      
REMARK 465     LYS M   215                                                      
REMARK 465     LYS M   216                                                      
REMARK 465     THR M   217                                                      
REMARK 465     SER M   218                                                      
REMARK 465     PHE M   219                                                      
REMARK 465     VAL M   220                                                      
REMARK 465     ASN M   221                                                      
REMARK 465     PHE M   222                                                      
REMARK 465     THR M   223                                                      
REMARK 465     ASP M   224                                                      
REMARK 465     ILE M   225                                                      
REMARK 465     CYS M   226                                                      
REMARK 465     LYS M   227                                                      
REMARK 465     LEU M   228                                                      
REMARK 465     LEU M   229                                                      
REMARK 465     HIS M   230                                                      
REMARK 465     ARG M   231                                                      
REMARK 465     GLN M   232                                                      
REMARK 465     PRO M   233                                                      
REMARK 465     LYS M   234                                                      
REMARK 465     HIS M   235                                                      
REMARK 465     LEU M   236                                                      
REMARK 465     LEU M   237                                                      
REMARK 465     ALA M   238                                                      
REMARK 465     PHE M   239                                                      
REMARK 465     LEU M   240                                                      
REMARK 465     LEU M   241                                                      
REMARK 465     ALA M   242                                                      
REMARK 465     GLU M   243                                                      
REMARK 465     LEU M   244                                                      
REMARK 465     GLY M   245                                                      
REMARK 465     THR M   246                                                      
REMARK 465     SER M   247                                                      
REMARK 465     GLY M   248                                                      
REMARK 465     SER M   249                                                      
REMARK 465     ILE M   250                                                      
REMARK 465     ASP M   251                                                      
REMARK 465     GLY M   252                                                      
REMARK 465     ASN M   253                                                      
REMARK 465     ASN M   254                                                      
REMARK 465     GLN M   255                                                      
REMARK 465     LEU M   256                                                      
REMARK 465     VAL M   257                                                      
REMARK 465     ILE M   258                                                      
REMARK 465     LYS M   259                                                      
REMARK 465     GLY M   260                                                      
REMARK 465     ARG M   261                                                      
REMARK 465     PHE M   262                                                      
REMARK 465     GLN M   263                                                      
REMARK 465     GLN M   264                                                      
REMARK 465     LYS M   265                                                      
REMARK 465     GLN M   266                                                      
REMARK 465     ILE M   267                                                      
REMARK 465     GLU M   268                                                      
REMARK 465     ASN M   269                                                      
REMARK 465     VAL M   270                                                      
REMARK 465     LEU M   271                                                      
REMARK 465     ARG M   272                                                      
REMARK 465     ARG M   273                                                      
REMARK 465     TYR M   274                                                      
REMARK 465     ILE M   275                                                      
REMARK 465     LYS M   276                                                      
REMARK 465     GLU M   277                                                      
REMARK 465     TYR M   278                                                      
REMARK 465     VAL M   279                                                      
REMARK 465     THR M   280                                                      
REMARK 465     CYS M   281                                                      
REMARK 465     HIS M   282                                                      
REMARK 465     THR M   283                                                      
REMARK 465     CYS M   284                                                      
REMARK 465     ARG M   285                                                      
REMARK 465     SER M   286                                                      
REMARK 465     PRO M   287                                                      
REMARK 465     ASP M   288                                                      
REMARK 465     THR M   289                                                      
REMARK 465     ILE M   290                                                      
REMARK 465     LEU M   291                                                      
REMARK 465     GLN M   292                                                      
REMARK 465     LYS M   293                                                      
REMARK 465     ASP M   294                                                      
REMARK 465     THR M   295                                                      
REMARK 465     ARG M   296                                                      
REMARK 465     LEU M   297                                                      
REMARK 465     TYR M   298                                                      
REMARK 465     PHE M   299                                                      
REMARK 465     LEU M   300                                                      
REMARK 465     GLN M   301                                                      
REMARK 465     CYS M   302                                                      
REMARK 465     GLU M   303                                                      
REMARK 465     THR M   304                                                      
REMARK 465     CYS M   305                                                      
REMARK 465     HIS M   306                                                      
REMARK 465     SER M   307                                                      
REMARK 465     ARG M   308                                                      
REMARK 465     CYS M   309                                                      
REMARK 465     SER M   310                                                      
REMARK 465     VAL M   311                                                      
REMARK 465     ALA M   312                                                      
REMARK 465     SER M   313                                                      
REMARK 465     ILE M   314                                                      
REMARK 465     LYS M   315                                                      
REMARK 465     THR M   316                                                      
REMARK 465     GLY M   317                                                      
REMARK 465     PHE M   318                                                      
REMARK 465     GLN M   319                                                      
REMARK 465     ALA M   320                                                      
REMARK 465     VAL M   321                                                      
REMARK 465     THR M   322                                                      
REMARK 465     GLY M   323                                                      
REMARK 465     LYS M   324                                                      
REMARK 465     ARG M   325                                                      
REMARK 465     ALA M   326                                                      
REMARK 465     GLN M   327                                                      
REMARK 465     LEU M   328                                                      
REMARK 465     ARG M   329                                                      
REMARK 465     ALA M   330                                                      
REMARK 465     LYS M   331                                                      
REMARK 465     ALA M   332                                                      
REMARK 465     ASN M   333                                                      
REMARK 465     MET P     1                                                      
REMARK 465     ALA P     2                                                      
REMARK 465     GLY P     3                                                      
REMARK 465     GLY P     4                                                      
REMARK 465     GLU P     5                                                      
REMARK 465     ALA P     6                                                      
REMARK 465     GLY P     7                                                      
REMARK 465     VAL P     8                                                      
REMARK 465     THR P     9                                                      
REMARK 465     LEU P    10                                                      
REMARK 465     GLY P    11                                                      
REMARK 465     GLN P    12                                                      
REMARK 465     PRO P    13                                                      
REMARK 465     HIS P    14                                                      
REMARK 465     LEU P    15                                                      
REMARK 465     SER P    16                                                      
REMARK 465     ARG P    17                                                      
REMARK 465     GLN P    18                                                      
REMARK 465     ASP P    19                                                      
REMARK 465     LEU P    20                                                      
REMARK 465     THR P    21                                                      
REMARK 465     THR P    22                                                      
REMARK 465     LEU P    23                                                      
REMARK 465     ASP P    24                                                      
REMARK 465     VAL P    25                                                      
REMARK 465     THR P    26                                                      
REMARK 465     LYS P    27                                                      
REMARK 465     LEU P    28                                                      
REMARK 465     THR P    29                                                      
REMARK 465     PRO P    30                                                      
REMARK 465     LEU P    31                                                      
REMARK 465     SER P    32                                                      
REMARK 465     HIS P    33                                                      
REMARK 465     GLU P    34                                                      
REMARK 465     VAL P    35                                                      
REMARK 465     ILE P    36                                                      
REMARK 465     SER P    37                                                      
REMARK 465     ARG P    38                                                      
REMARK 465     GLN P    39                                                      
REMARK 465     SER P   104                                                      
REMARK 465     CYS P   105                                                      
REMARK 465     GLY P   106                                                      
REMARK 465     SER P   107                                                      
REMARK 465     SER P   108                                                      
REMARK 465     THR P   109                                                      
REMARK 465     PRO P   110                                                      
REMARK 465     ASP P   111                                                      
REMARK 465     GLU P   112                                                      
REMARK 465     PHE P   113                                                      
REMARK 465     PRO P   114                                                      
REMARK 465     THR P   115                                                      
REMARK 465     ASP P   116                                                      
REMARK 465     ILE P   117                                                      
REMARK 465     PRO P   118                                                      
REMARK 465     ARG P   461                                                      
REMARK 465     GLY P   462                                                      
REMARK 465     VAL P   463                                                      
REMARK 465     THR P   464                                                      
REMARK 465     ILE P   465                                                      
REMARK 465     LYS P   466                                                      
REMARK 465     PRO P   467                                                      
REMARK 465     THR P   468                                                      
REMARK 465     VAL P   469                                                      
REMARK 465     ASP P   470                                                      
REMARK 465     ASP P   471                                                      
REMARK 465     ASP P   472                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     PRO E 277    CG   CD                                             
REMARK 470     ASP E 279    CG   OD1  OD2                                       
REMARK 470     CYS E 281    SG                                                  
REMARK 470     TRP E 282    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
REMARK 470     TRP E 282    CZ3  CH2                                            
REMARK 470     ASN E 283    CG   OD1  ND2                                       
REMARK 470     CYS E 285    SG                                                  
REMARK 470     ARG E 286    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP E 288    CG   OD1  OD2                                       
REMARK 470     ARG E 289    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     TRP E 290    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
REMARK 470     TRP E 290    CZ3  CH2                                            
REMARK 470     GLU E 291    CG   CD   OE1  OE2                                  
REMARK 470     ASP E 292    CG   OD1  OD2                                       
REMARK 470     SER E 342    OG                                                  
REMARK 470     SER E 343    OG                                                  
REMARK 470     GLN E 345    CG   CD   OE1  NE2                                  
REMARK 470     ILE E 346    CG1  CG2  CD1                                       
REMARK 470     VAL E 347    CG1  CG2                                            
REMARK 470     SER E 348    OG                                                  
REMARK 470     LYS E 349    CG   CD   CE   NZ                                   
REMARK 470     HIS E 350    CG   ND1  CD2  CE1  NE2                             
REMARK 470     LEU E 351    CG   CD1  CD2                                       
REMARK 470     VAL E 352    CG1  CG2                                            
REMARK 470     VAL E 354    CG1  CG2                                            
REMARK 470     ASP E 355    CG   OD1  OD2                                       
REMARK 470     SER E 356    OG                                                  
REMARK 470     LEU E 357    CG   CD1  CD2                                       
REMARK 470     ILE E 358    CG1  CG2  CD1                                       
REMARK 470     GLU E 361    CG   CD   OE1  OE2                                  
REMARK 470     THR E 362    OG1  CG2                                            
REMARK 470     GLN E 363    CG   CD   OE1  NE2                                  
REMARK 470     ILE E 364    CG1  CG2  CD1                                       
REMARK 470     GLU E 366    CG   CD   OE1  OE2                                  
REMARK 470     LYS E 367    CG   CD   CE   NZ                                   
REMARK 470     SER E 368    OG                                                  
REMARK 470     SER E 369    OG                                                  
REMARK 470     ILE E 370    CG1  CG2  CD1                                       
REMARK 470     LYS E 371    CG   CD   CE   NZ                                   
REMARK 470     ARG E 372    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     SER E 373    OG                                                  
REMARK 470     VAL E 374    CG1  CG2                                            
REMARK 470     ILE E 375    CG1  CG2  CD1                                       
REMARK 470     SER E 377    OG                                                  
REMARK 470     SER E 378    OG                                                  
REMARK 470     CYS E 379    SG                                                  
REMARK 470     LEU E 380    CG   CD1  CD2                                       
REMARK 470     ILE E 381    CG1  CG2  CD1                                       
REMARK 470     LYS E 382    CG   CD   CE   NZ                                   
REMARK 470     ASP E 383    CG   OD1  OD2                                       
REMARK 470     ARG E 384    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     VAL E 385    CG1  CG2                                            
REMARK 470     THR E 386    OG1  CG2                                            
REMARK 470     ILE E 387    CG1  CG2  CD1                                       
REMARK 470     THR E 388    OG1  CG2                                            
REMARK 470     ASN E 389    CG   OD1  ND2                                       
REMARK 470     CYS E 390    SG                                                  
REMARK 470     LEU E 391    CG   CD1  CD2                                       
REMARK 470     LEU E 392    CG   CD1  CD2                                       
REMARK 470     MET E 393    CG   SD   CE                                        
REMARK 470     ASN E 394    CG   OD1  ND2                                       
REMARK 470     SER E 395    OG                                                  
REMARK 470     VAL E 396    CG1  CG2                                            
REMARK 470     THR E 397    OG1  CG2                                            
REMARK 470     VAL E 398    CG1  CG2                                            
REMARK 470     GLU E 399    CG   CD   OE1  OE2                                  
REMARK 470     GLU E 400    CG   CD   OE1  OE2                                  
REMARK 470     SER E 402    OG                                                  
REMARK 470     ASN E 403    CG   OD1  ND2                                       
REMARK 470     ILE E 404    CG1  CG2  CD1                                       
REMARK 470     GLN E 405    CG   CD   OE1  NE2                                  
REMARK 470     SER E 407    OG                                                  
REMARK 470     VAL E 408    CG1  CG2                                            
REMARK 470     ILE E 409    CG1  CG2  CD1                                       
REMARK 470     CYS E 410    SG                                                  
REMARK 470     ASN E 411    CG   OD1  ND2                                       
REMARK 470     ASN E 412    CG   OD1  ND2                                       
REMARK 470     VAL E 414    CG1  CG2                                            
REMARK 470     ILE E 415    CG1  CG2  CD1                                       
REMARK 470     GLU E 416    CG   CD   OE1  OE2                                  
REMARK 470     LYS E 417    CG   CD   CE   NZ                                   
REMARK 470     ASP E 420    CG   OD1  OD2                                       
REMARK 470     ILE E 421    CG1  CG2  CD1                                       
REMARK 470     LYS E 422    CG   CD   CE   NZ                                   
REMARK 470     ASP E 423    CG   OD1  OD2                                       
REMARK 470     CYS E 424    SG                                                  
REMARK 470     LEU E 425    CG   CD1  CD2                                       
REMARK 470     ILE E 426    CG1  CG2  CD1                                       
REMARK 470     SER E 428    OG                                                  
REMARK 470     GLN E 430    CG   CD   OE1  NE2                                  
REMARK 470     ARG E 431    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ILE E 432    CG1  CG2  CD1                                       
REMARK 470     GLU E 433    CG   CD   OE1  OE2                                  
REMARK 470     LYS E 435    CG   CD   CE   NZ                                   
REMARK 470     LYS E 437    CG   CD   CE   NZ                                   
REMARK 470     ARG E 438    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     VAL E 439    CG1  CG2                                            
REMARK 470     ASN E 440    CG   OD1  ND2                                       
REMARK 470     GLU E 441    CG   CD   OE1  OE2                                  
REMARK 470     VAL E 442    CG1  CG2                                            
REMARK 470     ILE E 443    CG1  CG2  CD1                                       
REMARK 470     VAL E 444    CG1  CG2                                            
REMARK 470     PRO F 277    CG   CD                                             
REMARK 470     ASP F 279    CG   OD1  OD2                                       
REMARK 470     CYS F 281    SG                                                  
REMARK 470     TRP F 282    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
REMARK 470     TRP F 282    CZ3  CH2                                            
REMARK 470     ASN F 283    CG   OD1  ND2                                       
REMARK 470     CYS F 285    SG                                                  
REMARK 470     ARG F 286    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP F 288    CG   OD1  OD2                                       
REMARK 470     ARG F 289    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     TRP F 290    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
REMARK 470     TRP F 290    CZ3  CH2                                            
REMARK 470     GLU F 291    CG   CD   OE1  OE2                                  
REMARK 470     ASP F 292    CG   OD1  OD2                                       
REMARK 470     SER F 342    OG                                                  
REMARK 470     SER F 343    OG                                                  
REMARK 470     GLN F 345    CG   CD   OE1  NE2                                  
REMARK 470     ILE F 346    CG1  CG2  CD1                                       
REMARK 470     VAL F 347    CG1  CG2                                            
REMARK 470     SER F 348    OG                                                  
REMARK 470     LYS F 349    CG   CD   CE   NZ                                   
REMARK 470     HIS F 350    CG   ND1  CD2  CE1  NE2                             
REMARK 470     LEU F 351    CG   CD1  CD2                                       
REMARK 470     VAL F 352    CG1  CG2                                            
REMARK 470     VAL F 354    CG1  CG2                                            
REMARK 470     ASP F 355    CG   OD1  OD2                                       
REMARK 470     SER F 356    OG                                                  
REMARK 470     LEU F 357    CG   CD1  CD2                                       
REMARK 470     ILE F 358    CG1  CG2  CD1                                       
REMARK 470     GLU F 361    CG   CD   OE1  OE2                                  
REMARK 470     THR F 362    OG1  CG2                                            
REMARK 470     GLN F 363    CG   CD   OE1  NE2                                  
REMARK 470     ILE F 364    CG1  CG2  CD1                                       
REMARK 470     GLU F 366    CG   CD   OE1  OE2                                  
REMARK 470     LYS F 367    CG   CD   CE   NZ                                   
REMARK 470     SER F 368    OG                                                  
REMARK 470     SER F 369    OG                                                  
REMARK 470     ILE F 370    CG1  CG2  CD1                                       
REMARK 470     LYS F 371    CG   CD   CE   NZ                                   
REMARK 470     ARG F 372    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     SER F 373    OG                                                  
REMARK 470     VAL F 374    CG1  CG2                                            
REMARK 470     ILE F 375    CG1  CG2  CD1                                       
REMARK 470     SER F 377    OG                                                  
REMARK 470     SER F 378    OG                                                  
REMARK 470     CYS F 379    SG                                                  
REMARK 470     LEU F 380    CG   CD1  CD2                                       
REMARK 470     ILE F 381    CG1  CG2  CD1                                       
REMARK 470     LYS F 382    CG   CD   CE   NZ                                   
REMARK 470     ASP F 383    CG   OD1  OD2                                       
REMARK 470     ARG F 384    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     VAL F 385    CG1  CG2                                            
REMARK 470     THR F 386    OG1  CG2                                            
REMARK 470     ILE F 387    CG1  CG2  CD1                                       
REMARK 470     THR F 388    OG1  CG2                                            
REMARK 470     ASN F 389    CG   OD1  ND2                                       
REMARK 470     CYS F 390    SG                                                  
REMARK 470     LEU F 391    CG   CD1  CD2                                       
REMARK 470     LEU F 392    CG   CD1  CD2                                       
REMARK 470     MET F 393    CG   SD   CE                                        
REMARK 470     ASN F 394    CG   OD1  ND2                                       
REMARK 470     SER F 395    OG                                                  
REMARK 470     VAL F 396    CG1  CG2                                            
REMARK 470     THR F 397    OG1  CG2                                            
REMARK 470     VAL F 398    CG1  CG2                                            
REMARK 470     GLU F 399    CG   CD   OE1  OE2                                  
REMARK 470     GLU F 400    CG   CD   OE1  OE2                                  
REMARK 470     SER F 402    OG                                                  
REMARK 470     ASN F 403    CG   OD1  ND2                                       
REMARK 470     ILE F 404    CG1  CG2  CD1                                       
REMARK 470     GLN F 405    CG   CD   OE1  NE2                                  
REMARK 470     SER F 407    OG                                                  
REMARK 470     VAL F 408    CG1  CG2                                            
REMARK 470     ILE F 409    CG1  CG2  CD1                                       
REMARK 470     CYS F 410    SG                                                  
REMARK 470     ASN F 411    CG   OD1  ND2                                       
REMARK 470     ASN F 412    CG   OD1  ND2                                       
REMARK 470     VAL F 414    CG1  CG2                                            
REMARK 470     ILE F 415    CG1  CG2  CD1                                       
REMARK 470     GLU F 416    CG   CD   OE1  OE2                                  
REMARK 470     LYS F 417    CG   CD   CE   NZ                                   
REMARK 470     ASP F 420    CG   OD1  OD2                                       
REMARK 470     ILE F 421    CG1  CG2  CD1                                       
REMARK 470     LYS F 422    CG   CD   CE   NZ                                   
REMARK 470     ASP F 423    CG   OD1  OD2                                       
REMARK 470     CYS F 424    SG                                                  
REMARK 470     LEU F 425    CG   CD1  CD2                                       
REMARK 470     ILE F 426    CG1  CG2  CD1                                       
REMARK 470     SER F 428    OG                                                  
REMARK 470     GLN F 430    CG   CD   OE1  NE2                                  
REMARK 470     ARG F 431    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ILE F 432    CG1  CG2  CD1                                       
REMARK 470     GLU F 433    CG   CD   OE1  OE2                                  
REMARK 470     LYS F 435    CG   CD   CE   NZ                                   
REMARK 470     LYS F 437    CG   CD   CE   NZ                                   
REMARK 470     ARG F 438    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     VAL F 439    CG1  CG2                                            
REMARK 470     ASN F 440    CG   OD1  ND2                                       
REMARK 470     GLU F 441    CG   CD   OE1  OE2                                  
REMARK 470     VAL F 442    CG1  CG2                                            
REMARK 470     ILE F 443    CG1  CG2  CD1                                       
REMARK 470     VAL F 444    CG1  CG2                                            
REMARK 470     GLU J 678    CB   CG   CD   OE1  OE2                             
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   CB   VAL K   157     CD1  ILE K   180              1.56            
REMARK 500   CG1  VAL K   157     CD1  ILE K   180              1.70            
REMARK 500   CG2  VAL K   157     CD1  ILE K   180              1.86            
REMARK 500   O    ASN K   178     N    ARG K   182              1.98            
REMARK 500   ND2  ASN K   178     CD   ARG K   182              2.15            
REMARK 500   O    ASN K   178     CB   ARG K   182              2.16            
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500    CYS A 115   CA  -  CB  -  SG  ANGL. DEV. =   6.8 DEGREES          
REMARK 500    LEU A 168   CA  -  CB  -  CG  ANGL. DEV. =  13.9 DEGREES          
REMARK 500    LEU A 303   CA  -  CB  -  CG  ANGL. DEV. =  15.5 DEGREES          
REMARK 500    LEU C 265   CA  -  CB  -  CG  ANGL. DEV. =  17.0 DEGREES          
REMARK 500    ILE C 266   CG1 -  CB  -  CG2 ANGL. DEV. = -14.7 DEGREES          
REMARK 500    LEU F 180   CA  -  CB  -  CG  ANGL. DEV. =  15.5 DEGREES          
REMARK 500    LEU G 367   CA  -  CB  -  CG  ANGL. DEV. =  19.9 DEGREES          
REMARK 500    LEU H 482   CA  -  CB  -  CG  ANGL. DEV. =  21.1 DEGREES          
REMARK 500    LEU J 127   CA  -  CB  -  CG  ANGL. DEV. =  13.8 DEGREES          
REMARK 500    LEU J 431   CA  -  CB  -  CG  ANGL. DEV. =  14.0 DEGREES          
REMARK 500    LEU P  73   CA  -  CB  -  CG  ANGL. DEV. =  14.0 DEGREES          
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    ALA A  21     -168.99   -103.25                                   
REMARK 500    HIS A 128     -167.87   -125.25                                   
REMARK 500    ALA A 129     -179.51    -68.44                                   
REMARK 500    LYS A 145       60.26     64.18                                   
REMARK 500    SER A 160      -35.82   -131.14                                   
REMARK 500    LYS A 189       42.44   -109.03                                   
REMARK 500    ASN A 242     -159.39   -146.02                                   
REMARK 500    THR A 276     -158.17   -147.86                                   
REMARK 500    VAL B  59        1.27    -68.51                                   
REMARK 500    ILE B  92      -12.44   -143.94                                   
REMARK 500    LEU B 171       30.90    -98.81                                   
REMARK 500    ASN B 172       64.57     60.98                                   
REMARK 500    THR B 212      -38.87   -133.17                                   
REMARK 500    LYS B 234       38.19    -97.77                                   
REMARK 500    GLN B 244       35.66    -93.25                                   
REMARK 500    THR B 276     -148.20   -146.12                                   
REMARK 500    PRO B 278       43.26    -86.94                                   
REMARK 500    SER C   9       32.58    -92.86                                   
REMARK 500    LEU C  11      -39.92   -132.35                                   
REMARK 500    GLN C 128       28.20   -144.42                                   
REMARK 500    HIS C 160     -165.85   -128.13                                   
REMARK 500    ALA C 195       68.37   -118.78                                   
REMARK 500    GLN C 199       38.97   -142.70                                   
REMARK 500    LEU C 207       41.01   -107.15                                   
REMARK 500    SER C 208       12.40   -143.33                                   
REMARK 500    GLU C 213       81.77     58.15                                   
REMARK 500    ALA C 221       43.09   -109.33                                   
REMARK 500    SER C 227       31.33    -88.01                                   
REMARK 500    ASN C 230      -63.52    -95.83                                   
REMARK 500    ALA C 241       37.18    -99.82                                   
REMARK 500    PRO C 291       23.10    -77.43                                   
REMARK 500    PHE C 297       32.89    -92.29                                   
REMARK 500    ASP C 301       37.63    -97.56                                   
REMARK 500    SER C 334       31.28    -96.69                                   
REMARK 500    ASP C 348       57.65    -90.28                                   
REMARK 500    THR D  47      -70.22    -65.64                                   
REMARK 500    HIS D  49       74.59    -68.55                                   
REMARK 500    GLN D 154       35.12    -98.07                                   
REMARK 500    GLU D 157       31.37    -89.01                                   
REMARK 500    HIS D 160     -164.98   -118.23                                   
REMARK 500    PHE D 187     -169.91   -128.74                                   
REMARK 500    GLU D 213       71.52     59.21                                   
REMARK 500    ALA D 269       89.57   -155.71                                   
REMARK 500    GLU E   2      -67.00   -103.69                                   
REMARK 500    PRO E  29       45.30    -83.93                                   
REMARK 500    VAL E  46      -63.39    -99.07                                   
REMARK 500    PHE E  48       47.68     24.51                                   
REMARK 500    GLU E  50       53.78    -94.24                                   
REMARK 500    PHE E  67       30.92   -140.03                                   
REMARK 500    MET E  71       66.71     60.08                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     212 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS                                         
REMARK 500                                                                      
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH          
REMARK 500 CIS AND TRANS CONFORMATION.  CIS BONDS, IF ANY, ARE LISTED           
REMARK 500 ON CISPEP RECORDS.  TRANS IS DEFINED AS 180 +/- 30 AND               
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.                                  
REMARK 500                                 MODEL     OMEGA                      
REMARK 500 GLN A  156     PRO A  157                  132.75                    
REMARK 500 LEU A  168     CYS A  169                  148.37                    
REMARK 500 LEU A  280     ILE A  281                  149.51                    
REMARK 500 GLN B  156     PRO B  157                  140.55                    
REMARK 500 LYS B  224     PRO B  225                 -149.61                    
REMARK 500 LEU B  241     ASN B  242                 -143.37                    
REMARK 500 ILE B  301     LYS B  302                  148.48                    
REMARK 500 ALA C  195     PRO C  196                  146.18                    
REMARK 500 SER C  227     ARG C  228                  145.77                    
REMARK 500 TYR D  126     ALA D  127                 -143.60                    
REMARK 500 ASN D  327     ILE D  328                  148.85                    
REMARK 500 GLY E   47     PHE E   48                  126.78                    
REMARK 500 PRO E  230     TYR E  231                  145.83                    
REMARK 500 GLU F   44     ARG F   45                  149.17                    
REMARK 500 GLY F   47     PHE F   48                  137.92                    
REMARK 500 VAL F  101     LEU F  102                  146.95                    
REMARK 500 ASP F  119     LEU F  120                  144.53                    
REMARK 500 TYR G  186     SER G  187                  148.93                    
REMARK 500 GLU G  246     GLU G  247                 -147.37                    
REMARK 500 GLU H  348     ALA H  349                  147.34                    
REMARK 500 LEU H  395     PRO H  396                 -143.53                    
REMARK 500 VAL H  432     PRO H  433                 -149.77                    
REMARK 500 ASP H  450     ALA H  451                 -146.49                    
REMARK 500 PRO H  508     CYS H  509                 -141.02                    
REMARK 500 ASN J  118     VAL J  119                  144.61                    
REMARK 500 THR J  124     SER J  125                  148.06                    
REMARK 500 ILE J  249     SER J  250                 -136.84                    
REMARK 500 ILE J  314     ARG J  315                  149.50                    
REMARK 500 TYR K   39     ASN K   40                 -139.94                    
REMARK 500 GLU K   50     LEU K   51                  147.46                    
REMARK 500 VAL K  115     ALA K  116                  141.93                    
REMARK 500 ASP K  124     GLU K  125                  149.09                    
REMARK 500 ALA K  156     VAL K  157                 -143.46                    
REMARK 500 LEU K  168     ASN K  169                 -146.42                    
REMARK 500 GLU K  172     ARG K  173                 -147.46                    
REMARK 500 TYR K  202     GLU K  203                  148.82                    
REMARK 500 MET K  223     PRO K  224                  146.90                    
REMARK 500 ARG P   98     PRO P   99                 -146.03                    
REMARK 500 MET P  180     LYS P  181                  135.26                    
REMARK 500 GLU P  370     LEU P  371                 -148.65                    
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: EMD-9840   RELATED DB: EMDB                              
DBREF  6K71 A    1   305  UNP    Q14232   EI2BA_HUMAN      1    305             
DBREF  6K71 B    1   305  UNP    Q14232   EI2BA_HUMAN      1    305             
DBREF  6K71 C    1   351  UNP    P49770   EI2BB_HUMAN      1    351             
DBREF  6K71 D    1   351  UNP    P49770   EI2BB_HUMAN      1    351             
DBREF  6K71 E    1   452  UNP    Q9NR50   EI2BG_HUMAN      1    452             
DBREF  6K71 F    1   452  UNP    Q9NR50   EI2BG_HUMAN      1    452             
DBREF  6K71 G    1   523  UNP    Q9UI10   EI2BD_HUMAN      1    523             
DBREF  6K71 H    1   523  UNP    Q9UI10   EI2BD_HUMAN      1    523             
DBREF  6K71 I    1   721  UNP    Q13144   EI2BE_HUMAN      1    721             
DBREF  6K71 J    1   721  UNP    Q13144   EI2BE_HUMAN      1    721             
DBREF  6K71 K    1   315  UNP    P05198   IF2A_HUMAN       1    315             
DBREF  6K71 M    1   333  UNP    P20042   IF2B_HUMAN       1    333             
DBREF  6K71 P    1   472  UNP    P41091   IF2G_HUMAN       1    472             
SEQRES   1 A  305  MET ASP ASP LYS GLU LEU ILE GLU TYR PHE LYS SER GLN          
SEQRES   2 A  305  MET LYS GLU ASP PRO ASP MET ALA SER ALA VAL ALA ALA          
SEQRES   3 A  305  ILE ARG THR LEU LEU GLU PHE LEU LYS ARG ASP LYS GLY          
SEQRES   4 A  305  GLU THR ILE GLN GLY LEU ARG ALA ASN LEU THR SER ALA          
SEQRES   5 A  305  ILE GLU THR LEU CYS GLY VAL ASP SER SER VAL ALA VAL          
SEQRES   6 A  305  SER SER GLY GLY GLU LEU PHE LEU ARG PHE ILE SER LEU          
SEQRES   7 A  305  ALA SER LEU GLU TYR SER ASP TYR SER LYS CYS LYS LYS          
SEQRES   8 A  305  ILE MET ILE GLU ARG GLY GLU LEU PHE LEU ARG ARG ILE          
SEQRES   9 A  305  SER LEU SER ARG ASN LYS ILE ALA ASP LEU CYS HIS THR          
SEQRES  10 A  305  PHE ILE LYS ASP GLY ALA THR ILE LEU THR HIS ALA TYR          
SEQRES  11 A  305  SER ARG VAL VAL LEU ARG VAL LEU GLU ALA ALA VAL ALA          
SEQRES  12 A  305  ALA LYS LYS ARG PHE SER VAL TYR VAL THR GLU SER GLN          
SEQRES  13 A  305  PRO ASP LEU SER GLY LYS LYS MET ALA LYS ALA LEU CYS          
SEQRES  14 A  305  HIS LEU ASN VAL PRO VAL THR VAL VAL LEU ASP ALA ALA          
SEQRES  15 A  305  VAL GLY TYR ILE MET GLU LYS ALA ASP LEU VAL ILE VAL          
SEQRES  16 A  305  GLY ALA GLU GLY VAL VAL GLU ASN GLY GLY ILE ILE ASN          
SEQRES  17 A  305  LYS ILE GLY THR ASN GLN MET ALA VAL CYS ALA LYS ALA          
SEQRES  18 A  305  GLN ASN LYS PRO PHE TYR VAL VAL ALA GLU SER PHE LYS          
SEQRES  19 A  305  PHE VAL ARG LEU PHE PRO LEU ASN GLN GLN ASP VAL PRO          
SEQRES  20 A  305  ASP LYS PHE LYS TYR LYS ALA ASP THR LEU LYS VAL ALA          
SEQRES  21 A  305  GLN THR GLY GLN ASP LEU LYS GLU GLU HIS PRO TRP VAL          
SEQRES  22 A  305  ASP TYR THR ALA PRO SER LEU ILE THR LEU LEU PHE THR          
SEQRES  23 A  305  ASP LEU GLY VAL LEU THR PRO SER ALA VAL SER ASP GLU          
SEQRES  24 A  305  LEU ILE LYS LEU TYR LEU                                      
SEQRES   1 B  305  MET ASP ASP LYS GLU LEU ILE GLU TYR PHE LYS SER GLN          
SEQRES   2 B  305  MET LYS GLU ASP PRO ASP MET ALA SER ALA VAL ALA ALA          
SEQRES   3 B  305  ILE ARG THR LEU LEU GLU PHE LEU LYS ARG ASP LYS GLY          
SEQRES   4 B  305  GLU THR ILE GLN GLY LEU ARG ALA ASN LEU THR SER ALA          
SEQRES   5 B  305  ILE GLU THR LEU CYS GLY VAL ASP SER SER VAL ALA VAL          
SEQRES   6 B  305  SER SER GLY GLY GLU LEU PHE LEU ARG PHE ILE SER LEU          
SEQRES   7 B  305  ALA SER LEU GLU TYR SER ASP TYR SER LYS CYS LYS LYS          
SEQRES   8 B  305  ILE MET ILE GLU ARG GLY GLU LEU PHE LEU ARG ARG ILE          
SEQRES   9 B  305  SER LEU SER ARG ASN LYS ILE ALA ASP LEU CYS HIS THR          
SEQRES  10 B  305  PHE ILE LYS ASP GLY ALA THR ILE LEU THR HIS ALA TYR          
SEQRES  11 B  305  SER ARG VAL VAL LEU ARG VAL LEU GLU ALA ALA VAL ALA          
SEQRES  12 B  305  ALA LYS LYS ARG PHE SER VAL TYR VAL THR GLU SER GLN          
SEQRES  13 B  305  PRO ASP LEU SER GLY LYS LYS MET ALA LYS ALA LEU CYS          
SEQRES  14 B  305  HIS LEU ASN VAL PRO VAL THR VAL VAL LEU ASP ALA ALA          
SEQRES  15 B  305  VAL GLY TYR ILE MET GLU LYS ALA ASP LEU VAL ILE VAL          
SEQRES  16 B  305  GLY ALA GLU GLY VAL VAL GLU ASN GLY GLY ILE ILE ASN          
SEQRES  17 B  305  LYS ILE GLY THR ASN GLN MET ALA VAL CYS ALA LYS ALA          
SEQRES  18 B  305  GLN ASN LYS PRO PHE TYR VAL VAL ALA GLU SER PHE LYS          
SEQRES  19 B  305  PHE VAL ARG LEU PHE PRO LEU ASN GLN GLN ASP VAL PRO          
SEQRES  20 B  305  ASP LYS PHE LYS TYR LYS ALA ASP THR LEU LYS VAL ALA          
SEQRES  21 B  305  GLN THR GLY GLN ASP LEU LYS GLU GLU HIS PRO TRP VAL          
SEQRES  22 B  305  ASP TYR THR ALA PRO SER LEU ILE THR LEU LEU PHE THR          
SEQRES  23 B  305  ASP LEU GLY VAL LEU THR PRO SER ALA VAL SER ASP GLU          
SEQRES  24 B  305  LEU ILE LYS LEU TYR LEU                                      
SEQRES   1 C  351  MET PRO GLY SER ALA ALA LYS GLY SER GLU LEU SER GLU          
SEQRES   2 C  351  ARG ILE GLU SER PHE VAL GLU THR LEU LYS ARG GLY GLY          
SEQRES   3 C  351  GLY PRO ARG SER SER GLU GLU MET ALA ARG GLU THR LEU          
SEQRES   4 C  351  GLY LEU LEU ARG GLN ILE ILE THR ASP HIS ARG TRP SER          
SEQRES   5 C  351  ASN ALA GLY GLU LEU MET GLU LEU ILE ARG ARG GLU GLY          
SEQRES   6 C  351  ARG ARG MET THR ALA ALA GLN PRO SER GLU THR THR VAL          
SEQRES   7 C  351  GLY ASN MET VAL ARG ARG VAL LEU LYS ILE ILE ARG GLU          
SEQRES   8 C  351  GLU TYR GLY ARG LEU HIS GLY ARG SER ASP GLU SER ASP          
SEQRES   9 C  351  GLN GLN GLU SER LEU HIS LYS LEU LEU THR SER GLY GLY          
SEQRES  10 C  351  LEU ASN GLU ASP PHE SER PHE HIS TYR ALA GLN LEU GLN          
SEQRES  11 C  351  SER ASN ILE ILE GLU ALA ILE ASN GLU LEU LEU VAL GLU          
SEQRES  12 C  351  LEU GLU GLY THR MET GLU ASN ILE ALA ALA GLN ALA LEU          
SEQRES  13 C  351  GLU HIS ILE HIS SER ASN GLU VAL ILE MET THR ILE GLY          
SEQRES  14 C  351  PHE SER ARG THR VAL GLU ALA PHE LEU LYS GLU ALA ALA          
SEQRES  15 C  351  ARG LYS ARG LYS PHE HIS VAL ILE VAL ALA GLU CYS ALA          
SEQRES  16 C  351  PRO PHE CYS GLN GLY HIS GLU MET ALA VAL ASN LEU SER          
SEQRES  17 C  351  LYS ALA GLY ILE GLU THR THR VAL MET THR ASP ALA ALA          
SEQRES  18 C  351  ILE PHE ALA VAL MET SER ARG VAL ASN LYS VAL ILE ILE          
SEQRES  19 C  351  GLY THR LYS THR ILE LEU ALA ASN GLY ALA LEU ARG ALA          
SEQRES  20 C  351  VAL THR GLY THR HIS THR LEU ALA LEU ALA ALA LYS HIS          
SEQRES  21 C  351  HIS SER THR PRO LEU ILE VAL CYS ALA PRO MET PHE LYS          
SEQRES  22 C  351  LEU SER PRO GLN PHE PRO ASN GLU GLU ASP SER PHE HIS          
SEQRES  23 C  351  LYS PHE VAL ALA PRO GLU GLU VAL LEU PRO PHE THR GLU          
SEQRES  24 C  351  GLY ASP ILE LEU GLU LYS VAL SER VAL HIS CYS PRO VAL          
SEQRES  25 C  351  PHE ASP TYR VAL PRO PRO GLU LEU ILE THR LEU PHE ILE          
SEQRES  26 C  351  SER ASN ILE GLY GLY ASN ALA PRO SER TYR ILE TYR ARG          
SEQRES  27 C  351  LEU MET SER GLU LEU TYR HIS PRO ASP ASP HIS VAL LEU          
SEQRES   1 D  351  MET PRO GLY SER ALA ALA LYS GLY SER GLU LEU SER GLU          
SEQRES   2 D  351  ARG ILE GLU SER PHE VAL GLU THR LEU LYS ARG GLY GLY          
SEQRES   3 D  351  GLY PRO ARG SER SER GLU GLU MET ALA ARG GLU THR LEU          
SEQRES   4 D  351  GLY LEU LEU ARG GLN ILE ILE THR ASP HIS ARG TRP SER          
SEQRES   5 D  351  ASN ALA GLY GLU LEU MET GLU LEU ILE ARG ARG GLU GLY          
SEQRES   6 D  351  ARG ARG MET THR ALA ALA GLN PRO SER GLU THR THR VAL          
SEQRES   7 D  351  GLY ASN MET VAL ARG ARG VAL LEU LYS ILE ILE ARG GLU          
SEQRES   8 D  351  GLU TYR GLY ARG LEU HIS GLY ARG SER ASP GLU SER ASP          
SEQRES   9 D  351  GLN GLN GLU SER LEU HIS LYS LEU LEU THR SER GLY GLY          
SEQRES  10 D  351  LEU ASN GLU ASP PHE SER PHE HIS TYR ALA GLN LEU GLN          
SEQRES  11 D  351  SER ASN ILE ILE GLU ALA ILE ASN GLU LEU LEU VAL GLU          
SEQRES  12 D  351  LEU GLU GLY THR MET GLU ASN ILE ALA ALA GLN ALA LEU          
SEQRES  13 D  351  GLU HIS ILE HIS SER ASN GLU VAL ILE MET THR ILE GLY          
SEQRES  14 D  351  PHE SER ARG THR VAL GLU ALA PHE LEU LYS GLU ALA ALA          
SEQRES  15 D  351  ARG LYS ARG LYS PHE HIS VAL ILE VAL ALA GLU CYS ALA          
SEQRES  16 D  351  PRO PHE CYS GLN GLY HIS GLU MET ALA VAL ASN LEU SER          
SEQRES  17 D  351  LYS ALA GLY ILE GLU THR THR VAL MET THR ASP ALA ALA          
SEQRES  18 D  351  ILE PHE ALA VAL MET SER ARG VAL ASN LYS VAL ILE ILE          
SEQRES  19 D  351  GLY THR LYS THR ILE LEU ALA ASN GLY ALA LEU ARG ALA          
SEQRES  20 D  351  VAL THR GLY THR HIS THR LEU ALA LEU ALA ALA LYS HIS          
SEQRES  21 D  351  HIS SER THR PRO LEU ILE VAL CYS ALA PRO MET PHE LYS          
SEQRES  22 D  351  LEU SER PRO GLN PHE PRO ASN GLU GLU ASP SER PHE HIS          
SEQRES  23 D  351  LYS PHE VAL ALA PRO GLU GLU VAL LEU PRO PHE THR GLU          
SEQRES  24 D  351  GLY ASP ILE LEU GLU LYS VAL SER VAL HIS CYS PRO VAL          
SEQRES  25 D  351  PHE ASP TYR VAL PRO PRO GLU LEU ILE THR LEU PHE ILE          
SEQRES  26 D  351  SER ASN ILE GLY GLY ASN ALA PRO SER TYR ILE TYR ARG          
SEQRES  27 D  351  LEU MET SER GLU LEU TYR HIS PRO ASP ASP HIS VAL LEU          
SEQRES   1 E  452  MET GLU PHE GLN ALA VAL VAL MET ALA VAL GLY GLY GLY          
SEQRES   2 E  452  SER ARG MET THR ASP LEU THR SER SER ILE PRO LYS PRO          
SEQRES   3 E  452  LEU LEU PRO VAL GLY ASN LYS PRO LEU ILE TRP TYR PRO          
SEQRES   4 E  452  LEU ASN LEU LEU GLU ARG VAL GLY PHE GLU GLU VAL ILE          
SEQRES   5 E  452  VAL VAL THR THR ARG ASP VAL GLN LYS ALA LEU CYS ALA          
SEQRES   6 E  452  GLU PHE LYS MET LYS MET LYS PRO ASP ILE VAL CYS ILE          
SEQRES   7 E  452  PRO ASP ASP ALA ASP MET GLY THR ALA ASP SER LEU ARG          
SEQRES   8 E  452  TYR ILE TYR PRO LYS LEU LYS THR ASP VAL LEU VAL LEU          
SEQRES   9 E  452  SER CYS ASP LEU ILE THR ASP VAL ALA LEU HIS GLU VAL          
SEQRES  10 E  452  VAL ASP LEU PHE ARG ALA TYR ASP ALA SER LEU ALA MET          
SEQRES  11 E  452  LEU MET ARG LYS GLY GLN ASP SER ILE GLU PRO VAL PRO          
SEQRES  12 E  452  GLY GLN LYS GLY LYS LYS LYS ALA VAL GLU GLN ARG ASP          
SEQRES  13 E  452  PHE ILE GLY VAL ASP SER THR GLY LYS ARG LEU LEU PHE          
SEQRES  14 E  452  MET ALA ASN GLU ALA ASP LEU ASP GLU GLU LEU VAL ILE          
SEQRES  15 E  452  LYS GLY SER ILE LEU GLN LYS HIS PRO ARG ILE ARG PHE          
SEQRES  16 E  452  HIS THR GLY LEU VAL ASP ALA HIS LEU TYR CYS LEU LYS          
SEQRES  17 E  452  LYS TYR ILE VAL ASP PHE LEU MET GLU ASN GLY SER ILE          
SEQRES  18 E  452  THR SER ILE ARG SER GLU LEU ILE PRO TYR LEU VAL ARG          
SEQRES  19 E  452  LYS GLN PHE SER SER ALA SER SER GLN GLN GLY GLN GLU          
SEQRES  20 E  452  GLU LYS GLU GLU ASP LEU LYS LYS LYS GLU LEU LYS SER          
SEQRES  21 E  452  LEU ASP ILE TYR SER PHE ILE LYS GLU ALA ASN THR LEU          
SEQRES  22 E  452  ASN LEU ALA PRO TYR ASP ALA CYS TRP ASN ALA CYS ARG          
SEQRES  23 E  452  GLY ASP ARG TRP GLU ASP LEU SER ARG SER GLN VAL ARG          
SEQRES  24 E  452  CYS TYR VAL HIS ILE MET LYS GLU GLY LEU CYS SER ARG          
SEQRES  25 E  452  VAL SER THR LEU GLY LEU TYR MET GLU ALA ASN ARG GLN          
SEQRES  26 E  452  VAL PRO LYS LEU LEU SER ALA LEU CYS PRO GLU GLU PRO          
SEQRES  27 E  452  PRO VAL HIS SER SER ALA GLN ILE VAL SER LYS HIS LEU          
SEQRES  28 E  452  VAL GLY VAL ASP SER LEU ILE GLY PRO GLU THR GLN ILE          
SEQRES  29 E  452  GLY GLU LYS SER SER ILE LYS ARG SER VAL ILE GLY SER          
SEQRES  30 E  452  SER CYS LEU ILE LYS ASP ARG VAL THR ILE THR ASN CYS          
SEQRES  31 E  452  LEU LEU MET ASN SER VAL THR VAL GLU GLU GLY SER ASN          
SEQRES  32 E  452  ILE GLN GLY SER VAL ILE CYS ASN ASN ALA VAL ILE GLU          
SEQRES  33 E  452  LYS GLY ALA ASP ILE LYS ASP CYS LEU ILE GLY SER GLY          
SEQRES  34 E  452  GLN ARG ILE GLU ALA LYS ALA LYS ARG VAL ASN GLU VAL          
SEQRES  35 E  452  ILE VAL GLY ASN ASP GLN LEU MET GLU ILE                      
SEQRES   1 F  452  MET GLU PHE GLN ALA VAL VAL MET ALA VAL GLY GLY GLY          
SEQRES   2 F  452  SER ARG MET THR ASP LEU THR SER SER ILE PRO LYS PRO          
SEQRES   3 F  452  LEU LEU PRO VAL GLY ASN LYS PRO LEU ILE TRP TYR PRO          
SEQRES   4 F  452  LEU ASN LEU LEU GLU ARG VAL GLY PHE GLU GLU VAL ILE          
SEQRES   5 F  452  VAL VAL THR THR ARG ASP VAL GLN LYS ALA LEU CYS ALA          
SEQRES   6 F  452  GLU PHE LYS MET LYS MET LYS PRO ASP ILE VAL CYS ILE          
SEQRES   7 F  452  PRO ASP ASP ALA ASP MET GLY THR ALA ASP SER LEU ARG          
SEQRES   8 F  452  TYR ILE TYR PRO LYS LEU LYS THR ASP VAL LEU VAL LEU          
SEQRES   9 F  452  SER CYS ASP LEU ILE THR ASP VAL ALA LEU HIS GLU VAL          
SEQRES  10 F  452  VAL ASP LEU PHE ARG ALA TYR ASP ALA SER LEU ALA MET          
SEQRES  11 F  452  LEU MET ARG LYS GLY GLN ASP SER ILE GLU PRO VAL PRO          
SEQRES  12 F  452  GLY GLN LYS GLY LYS LYS LYS ALA VAL GLU GLN ARG ASP          
SEQRES  13 F  452  PHE ILE GLY VAL ASP SER THR GLY LYS ARG LEU LEU PHE          
SEQRES  14 F  452  MET ALA ASN GLU ALA ASP LEU ASP GLU GLU LEU VAL ILE          
SEQRES  15 F  452  LYS GLY SER ILE LEU GLN LYS HIS PRO ARG ILE ARG PHE          
SEQRES  16 F  452  HIS THR GLY LEU VAL ASP ALA HIS LEU TYR CYS LEU LYS          
SEQRES  17 F  452  LYS TYR ILE VAL ASP PHE LEU MET GLU ASN GLY SER ILE          
SEQRES  18 F  452  THR SER ILE ARG SER GLU LEU ILE PRO TYR LEU VAL ARG          
SEQRES  19 F  452  LYS GLN PHE SER SER ALA SER SER GLN GLN GLY GLN GLU          
SEQRES  20 F  452  GLU LYS GLU GLU ASP LEU LYS LYS LYS GLU LEU LYS SER          
SEQRES  21 F  452  LEU ASP ILE TYR SER PHE ILE LYS GLU ALA ASN THR LEU          
SEQRES  22 F  452  ASN LEU ALA PRO TYR ASP ALA CYS TRP ASN ALA CYS ARG          
SEQRES  23 F  452  GLY ASP ARG TRP GLU ASP LEU SER ARG SER GLN VAL ARG          
SEQRES  24 F  452  CYS TYR VAL HIS ILE MET LYS GLU GLY LEU CYS SER ARG          
SEQRES  25 F  452  VAL SER THR LEU GLY LEU TYR MET GLU ALA ASN ARG GLN          
SEQRES  26 F  452  VAL PRO LYS LEU LEU SER ALA LEU CYS PRO GLU GLU PRO          
SEQRES  27 F  452  PRO VAL HIS SER SER ALA GLN ILE VAL SER LYS HIS LEU          
SEQRES  28 F  452  VAL GLY VAL ASP SER LEU ILE GLY PRO GLU THR GLN ILE          
SEQRES  29 F  452  GLY GLU LYS SER SER ILE LYS ARG SER VAL ILE GLY SER          
SEQRES  30 F  452  SER CYS LEU ILE LYS ASP ARG VAL THR ILE THR ASN CYS          
SEQRES  31 F  452  LEU LEU MET ASN SER VAL THR VAL GLU GLU GLY SER ASN          
SEQRES  32 F  452  ILE GLN GLY SER VAL ILE CYS ASN ASN ALA VAL ILE GLU          
SEQRES  33 F  452  LYS GLY ALA ASP ILE LYS ASP CYS LEU ILE GLY SER GLY          
SEQRES  34 F  452  GLN ARG ILE GLU ALA LYS ALA LYS ARG VAL ASN GLU VAL          
SEQRES  35 F  452  ILE VAL GLY ASN ASP GLN LEU MET GLU ILE                      
SEQRES   1 G  523  MET ALA ALA VAL ALA VAL ALA VAL ARG GLU ASP SER GLY          
SEQRES   2 G  523  SER GLY MET LYS ALA GLU LEU PRO PRO GLY PRO GLY ALA          
SEQRES   3 G  523  VAL GLY ARG GLU MET THR LYS GLU GLU LYS LEU GLN LEU          
SEQRES   4 G  523  ARG LYS GLU LYS LYS GLN GLN LYS LYS LYS ARG LYS GLU          
SEQRES   5 G  523  GLU LYS GLY ALA GLU PRO GLU THR GLY SER ALA VAL SER          
SEQRES   6 G  523  ALA ALA GLN CYS GLN VAL GLY PRO THR ARG GLU LEU PRO          
SEQRES   7 G  523  GLU SER GLY ILE GLN LEU GLY THR PRO ARG GLU LYS VAL          
SEQRES   8 G  523  PRO ALA GLY ARG SER LYS ALA GLU LEU ARG ALA GLU ARG          
SEQRES   9 G  523  ARG ALA LYS GLN GLU ALA GLU ARG ALA LEU LYS GLN ALA          
SEQRES  10 G  523  ARG LYS GLY GLU GLN GLY GLY PRO PRO PRO LYS ALA SER          
SEQRES  11 G  523  PRO SER THR ALA GLY GLU THR PRO SER GLY VAL LYS ARG          
SEQRES  12 G  523  LEU PRO GLU TYR PRO GLN VAL ASP ASP LEU LEU LEU ARG          
SEQRES  13 G  523  ARG LEU VAL LYS LYS PRO GLU ARG GLN GLN VAL PRO THR          
SEQRES  14 G  523  ARG LYS ASP TYR GLY SER LYS VAL SER LEU PHE SER HIS          
SEQRES  15 G  523  LEU PRO GLN TYR SER ARG GLN ASN SER LEU THR GLN PHE          
SEQRES  16 G  523  MET SER ILE PRO SER SER VAL ILE HIS PRO ALA MET VAL          
SEQRES  17 G  523  ARG LEU GLY LEU GLN TYR SER GLN GLY LEU VAL SER GLY          
SEQRES  18 G  523  SER ASN ALA ARG CYS ILE ALA LEU LEU ARG ALA LEU GLN          
SEQRES  19 G  523  GLN VAL ILE GLN ASP TYR THR THR PRO PRO ASN GLU GLU          
SEQRES  20 G  523  LEU SER ARG ASP LEU VAL ASN LYS LEU LYS PRO TYR MET          
SEQRES  21 G  523  SER PHE LEU THR GLN CYS ARG PRO LEU SER ALA SER MET          
SEQRES  22 G  523  HIS ASN ALA ILE LYS PHE LEU ASN LYS GLU ILE THR SER          
SEQRES  23 G  523  VAL GLY SER SER LYS ARG GLU GLU GLU ALA LYS SER GLU          
SEQRES  24 G  523  LEU ARG ALA ALA ILE ASP ARG TYR VAL GLN GLU LYS ILE          
SEQRES  25 G  523  VAL LEU ALA ALA GLN ALA ILE SER ARG PHE ALA TYR GLN          
SEQRES  26 G  523  LYS ILE SER ASN GLY ASP VAL ILE LEU VAL TYR GLY CYS          
SEQRES  27 G  523  SER SER LEU VAL SER ARG ILE LEU GLN GLU ALA TRP THR          
SEQRES  28 G  523  GLU GLY ARG ARG PHE ARG VAL VAL VAL VAL ASP SER ARG          
SEQRES  29 G  523  PRO TRP LEU GLU GLY ARG HIS THR LEU ARG SER LEU VAL          
SEQRES  30 G  523  HIS ALA GLY VAL PRO ALA SER TYR LEU LEU ILE PRO ALA          
SEQRES  31 G  523  ALA SER TYR VAL LEU PRO GLU VAL SER LYS VAL LEU LEU          
SEQRES  32 G  523  GLY ALA HIS ALA LEU LEU ALA ASN GLY SER VAL MET SER          
SEQRES  33 G  523  ARG VAL GLY THR ALA GLN LEU ALA LEU VAL ALA ARG ALA          
SEQRES  34 G  523  HIS ASN VAL PRO VAL LEU VAL CYS CYS GLU THR TYR LYS          
SEQRES  35 G  523  PHE CYS GLU ARG VAL GLN THR ASP ALA PHE VAL SER ASN          
SEQRES  36 G  523  GLU LEU ASP ASP PRO ASP ASP LEU GLN CYS LYS ARG GLY          
SEQRES  37 G  523  GLU HIS VAL ALA LEU ALA ASN TRP GLN ASN HIS ALA SER          
SEQRES  38 G  523  LEU ARG LEU LEU ASN LEU VAL TYR ASP VAL THR PRO PRO          
SEQRES  39 G  523  GLU LEU VAL ASP LEU VAL ILE THR GLU LEU GLY MET ILE          
SEQRES  40 G  523  PRO CYS SER SER VAL PRO VAL VAL LEU ARG VAL LYS SER          
SEQRES  41 G  523  SER ASP GLN                                                  
SEQRES   1 H  523  MET ALA ALA VAL ALA VAL ALA VAL ARG GLU ASP SER GLY          
SEQRES   2 H  523  SER GLY MET LYS ALA GLU LEU PRO PRO GLY PRO GLY ALA          
SEQRES   3 H  523  VAL GLY ARG GLU MET THR LYS GLU GLU LYS LEU GLN LEU          
SEQRES   4 H  523  ARG LYS GLU LYS LYS GLN GLN LYS LYS LYS ARG LYS GLU          
SEQRES   5 H  523  GLU LYS GLY ALA GLU PRO GLU THR GLY SER ALA VAL SER          
SEQRES   6 H  523  ALA ALA GLN CYS GLN VAL GLY PRO THR ARG GLU LEU PRO          
SEQRES   7 H  523  GLU SER GLY ILE GLN LEU GLY THR PRO ARG GLU LYS VAL          
SEQRES   8 H  523  PRO ALA GLY ARG SER LYS ALA GLU LEU ARG ALA GLU ARG          
SEQRES   9 H  523  ARG ALA LYS GLN GLU ALA GLU ARG ALA LEU LYS GLN ALA          
SEQRES  10 H  523  ARG LYS GLY GLU GLN GLY GLY PRO PRO PRO LYS ALA SER          
SEQRES  11 H  523  PRO SER THR ALA GLY GLU THR PRO SER GLY VAL LYS ARG          
SEQRES  12 H  523  LEU PRO GLU TYR PRO GLN VAL ASP ASP LEU LEU LEU ARG          
SEQRES  13 H  523  ARG LEU VAL LYS LYS PRO GLU ARG GLN GLN VAL PRO THR          
SEQRES  14 H  523  ARG LYS ASP TYR GLY SER LYS VAL SER LEU PHE SER HIS          
SEQRES  15 H  523  LEU PRO GLN TYR SER ARG GLN ASN SER LEU THR GLN PHE          
SEQRES  16 H  523  MET SER ILE PRO SER SER VAL ILE HIS PRO ALA MET VAL          
SEQRES  17 H  523  ARG LEU GLY LEU GLN TYR SER GLN GLY LEU VAL SER GLY          
SEQRES  18 H  523  SER ASN ALA ARG CYS ILE ALA LEU LEU ARG ALA LEU GLN          
SEQRES  19 H  523  GLN VAL ILE GLN ASP TYR THR THR PRO PRO ASN GLU GLU          
SEQRES  20 H  523  LEU SER ARG ASP LEU VAL ASN LYS LEU LYS PRO TYR MET          
SEQRES  21 H  523  SER PHE LEU THR GLN CYS ARG PRO LEU SER ALA SER MET          
SEQRES  22 H  523  HIS ASN ALA ILE LYS PHE LEU ASN LYS GLU ILE THR SER          
SEQRES  23 H  523  VAL GLY SER SER LYS ARG GLU GLU GLU ALA LYS SER GLU          
SEQRES  24 H  523  LEU ARG ALA ALA ILE ASP ARG TYR VAL GLN GLU LYS ILE          
SEQRES  25 H  523  VAL LEU ALA ALA GLN ALA ILE SER ARG PHE ALA TYR GLN          
SEQRES  26 H  523  LYS ILE SER ASN GLY ASP VAL ILE LEU VAL TYR GLY CYS          
SEQRES  27 H  523  SER SER LEU VAL SER ARG ILE LEU GLN GLU ALA TRP THR          
SEQRES  28 H  523  GLU GLY ARG ARG PHE ARG VAL VAL VAL VAL ASP SER ARG          
SEQRES  29 H  523  PRO TRP LEU GLU GLY ARG HIS THR LEU ARG SER LEU VAL          
SEQRES  30 H  523  HIS ALA GLY VAL PRO ALA SER TYR LEU LEU ILE PRO ALA          
SEQRES  31 H  523  ALA SER TYR VAL LEU PRO GLU VAL SER LYS VAL LEU LEU          
SEQRES  32 H  523  GLY ALA HIS ALA LEU LEU ALA ASN GLY SER VAL MET SER          
SEQRES  33 H  523  ARG VAL GLY THR ALA GLN LEU ALA LEU VAL ALA ARG ALA          
SEQRES  34 H  523  HIS ASN VAL PRO VAL LEU VAL CYS CYS GLU THR TYR LYS          
SEQRES  35 H  523  PHE CYS GLU ARG VAL GLN THR ASP ALA PHE VAL SER ASN          
SEQRES  36 H  523  GLU LEU ASP ASP PRO ASP ASP LEU GLN CYS LYS ARG GLY          
SEQRES  37 H  523  GLU HIS VAL ALA LEU ALA ASN TRP GLN ASN HIS ALA SER          
SEQRES  38 H  523  LEU ARG LEU LEU ASN LEU VAL TYR ASP VAL THR PRO PRO          
SEQRES  39 H  523  GLU LEU VAL ASP LEU VAL ILE THR GLU LEU GLY MET ILE          
SEQRES  40 H  523  PRO CYS SER SER VAL PRO VAL VAL LEU ARG VAL LYS SER          
SEQRES  41 H  523  SER ASP GLN                                                  
SEQRES   1 I  721  MET ALA ALA PRO VAL VAL ALA PRO PRO GLY VAL VAL VAL          
SEQRES   2 I  721  SER ARG ALA ASN LYS ARG SER GLY ALA GLY PRO GLY GLY          
SEQRES   3 I  721  SER GLY GLY GLY GLY ALA ARG GLY ALA GLU GLU GLU PRO          
SEQRES   4 I  721  PRO PRO PRO LEU GLN ALA VAL LEU VAL ALA ASP SER PHE          
SEQRES   5 I  721  ASP ARG ARG PHE PHE PRO ILE SER LYS ASP GLN PRO ARG          
SEQRES   6 I  721  VAL LEU LEU PRO LEU ALA ASN VAL ALA LEU ILE ASP TYR          
SEQRES   7 I  721  THR LEU GLU PHE LEU THR ALA THR GLY VAL GLN GLU THR          
SEQRES   8 I  721  PHE VAL PHE CYS CYS TRP LYS ALA ALA GLN ILE LYS GLU          
SEQRES   9 I  721  HIS LEU LEU LYS SER LYS TRP CYS ARG PRO THR SER LEU          
SEQRES  10 I  721  ASN VAL VAL ARG ILE ILE THR SER GLU LEU TYR ARG SER          
SEQRES  11 I  721  LEU GLY ASP VAL LEU ARG ASP VAL ASP ALA LYS ALA LEU          
SEQRES  12 I  721  VAL ARG SER ASP PHE LEU LEU VAL TYR GLY ASP VAL ILE          
SEQRES  13 I  721  SER ASN ILE ASN ILE THR ARG ALA LEU GLU GLU HIS ARG          
SEQRES  14 I  721  LEU ARG ARG LYS LEU GLU LYS ASN VAL SER VAL MET THR          
SEQRES  15 I  721  MET ILE PHE LYS GLU SER SER PRO SER HIS PRO THR ARG          
SEQRES  16 I  721  CYS HIS GLU ASP ASN VAL VAL VAL ALA VAL ASP SER THR          
SEQRES  17 I  721  THR ASN ARG VAL LEU HIS PHE GLN LYS THR GLN GLY LEU          
SEQRES  18 I  721  ARG ARG PHE ALA PHE PRO LEU SER LEU PHE GLN GLY SER          
SEQRES  19 I  721  SER ASP GLY VAL GLU VAL ARG TYR ASP LEU LEU ASP CYS          
SEQRES  20 I  721  HIS ILE SER ILE CYS SER PRO GLN VAL ALA GLN LEU PHE          
SEQRES  21 I  721  THR ASP ASN PHE ASP TYR GLN THR ARG ASP ASP PHE VAL          
SEQRES  22 I  721  ARG GLY LEU LEU VAL ASN GLU GLU ILE LEU GLY ASN GLN          
SEQRES  23 I  721  ILE HIS MET HIS VAL THR ALA LYS GLU TYR GLY ALA ARG          
SEQRES  24 I  721  VAL SER ASN LEU HIS MET TYR SER ALA VAL CYS ALA ASP          
SEQRES  25 I  721  VAL ILE ARG ARG TRP VAL TYR PRO LEU THR PRO GLU ALA          
SEQRES  26 I  721  ASN PHE THR ASP SER THR THR GLN SER CYS THR HIS SER          
SEQRES  27 I  721  ARG HIS ASN ILE TYR ARG GLY PRO GLU VAL SER LEU GLY          
SEQRES  28 I  721  HIS GLY SER ILE LEU GLU GLU ASN VAL LEU LEU GLY SER          
SEQRES  29 I  721  GLY THR VAL ILE GLY SER ASN CYS PHE ILE THR ASN SER          
SEQRES  30 I  721  VAL ILE GLY PRO GLY CYS HIS ILE GLY ASP ASN VAL VAL          
SEQRES  31 I  721  LEU ASP GLN THR TYR LEU TRP GLN GLY VAL ARG VAL ALA          
SEQRES  32 I  721  ALA GLY ALA GLN ILE HIS GLN SER LEU LEU CYS ASP ASN          
SEQRES  33 I  721  ALA GLU VAL LYS GLU ARG VAL THR LEU LYS PRO ARG SER          
SEQRES  34 I  721  VAL LEU THR SER GLN VAL VAL VAL GLY PRO ASN ILE THR          
SEQRES  35 I  721  LEU PRO GLU GLY SER VAL ILE SER LEU HIS PRO PRO ASP          
SEQRES  36 I  721  ALA GLU GLU ASP GLU ASP ASP GLY GLU PHE SER ASP ASP          
SEQRES  37 I  721  SER GLY ALA ASP GLN GLU LYS ASP LYS VAL LYS MET LYS          
SEQRES  38 I  721  GLY TYR ASN PRO ALA GLU VAL GLY ALA ALA GLY LYS GLY          
SEQRES  39 I  721  TYR LEU TRP LYS ALA ALA GLY MET ASN MET GLU GLU GLU          
SEQRES  40 I  721  GLU GLU LEU GLN GLN ASN LEU TRP GLY LEU LYS ILE ASN          
SEQRES  41 I  721  MET GLU GLU GLU SER GLU SER GLU SER GLU GLN SER MET          
SEQRES  42 I  721  ASP SER GLU GLU PRO ASP SER ARG GLY GLY SER PRO GLN          
SEQRES  43 I  721  MET ASP ASP ILE LYS VAL PHE GLN ASN GLU VAL LEU GLY          
SEQRES  44 I  721  THR LEU GLN ARG GLY LYS GLU GLU ASN ILE SER CYS ASP          
SEQRES  45 I  721  ASN LEU VAL LEU GLU ILE ASN SER LEU LYS TYR ALA TYR          
SEQRES  46 I  721  ASN ILE SER LEU LYS GLU VAL MET GLN VAL LEU SER HIS          
SEQRES  47 I  721  VAL VAL LEU GLU PHE PRO LEU GLN GLN MET ASP SER PRO          
SEQRES  48 I  721  LEU ASP SER SER ARG TYR CYS ALA LEU LEU LEU PRO LEU          
SEQRES  49 I  721  LEU LYS ALA TRP SER PRO VAL PHE ARG ASN TYR ILE LYS          
SEQRES  50 I  721  ARG ALA ALA ASP HIS LEU GLU ALA LEU ALA ALA ILE GLU          
SEQRES  51 I  721  ASP PHE PHE LEU GLU HIS GLU ALA LEU GLY ILE SER MET          
SEQRES  52 I  721  ALA LYS VAL LEU MET ALA PHE TYR GLN LEU GLU ILE LEU          
SEQRES  53 I  721  ALA GLU GLU THR ILE LEU SER TRP PHE SER GLN ARG ASP          
SEQRES  54 I  721  THR THR ASP LYS GLY GLN GLN LEU ARG LYS ASN GLN GLN          
SEQRES  55 I  721  LEU GLN ARG PHE ILE GLN TRP LEU LYS GLU ALA GLU GLU          
SEQRES  56 I  721  GLU SER SER GLU ASP ASP                                      
SEQRES   1 J  721  MET ALA ALA PRO VAL VAL ALA PRO PRO GLY VAL VAL VAL          
SEQRES   2 J  721  SER ARG ALA ASN LYS ARG SER GLY ALA GLY PRO GLY GLY          
SEQRES   3 J  721  SER GLY GLY GLY GLY ALA ARG GLY ALA GLU GLU GLU PRO          
SEQRES   4 J  721  PRO PRO PRO LEU GLN ALA VAL LEU VAL ALA ASP SER PHE          
SEQRES   5 J  721  ASP ARG ARG PHE PHE PRO ILE SER LYS ASP GLN PRO ARG          
SEQRES   6 J  721  VAL LEU LEU PRO LEU ALA ASN VAL ALA LEU ILE ASP TYR          
SEQRES   7 J  721  THR LEU GLU PHE LEU THR ALA THR GLY VAL GLN GLU THR          
SEQRES   8 J  721  PHE VAL PHE CYS CYS TRP LYS ALA ALA GLN ILE LYS GLU          
SEQRES   9 J  721  HIS LEU LEU LYS SER LYS TRP CYS ARG PRO THR SER LEU          
SEQRES  10 J  721  ASN VAL VAL ARG ILE ILE THR SER GLU LEU TYR ARG SER          
SEQRES  11 J  721  LEU GLY ASP VAL LEU ARG ASP VAL ASP ALA LYS ALA LEU          
SEQRES  12 J  721  VAL ARG SER ASP PHE LEU LEU VAL TYR GLY ASP VAL ILE          
SEQRES  13 J  721  SER ASN ILE ASN ILE THR ARG ALA LEU GLU GLU HIS ARG          
SEQRES  14 J  721  LEU ARG ARG LYS LEU GLU LYS ASN VAL SER VAL MET THR          
SEQRES  15 J  721  MET ILE PHE LYS GLU SER SER PRO SER HIS PRO THR ARG          
SEQRES  16 J  721  CYS HIS GLU ASP ASN VAL VAL VAL ALA VAL ASP SER THR          
SEQRES  17 J  721  THR ASN ARG VAL LEU HIS PHE GLN LYS THR GLN GLY LEU          
SEQRES  18 J  721  ARG ARG PHE ALA PHE PRO LEU SER LEU PHE GLN GLY SER          
SEQRES  19 J  721  SER ASP GLY VAL GLU VAL ARG TYR ASP LEU LEU ASP CYS          
SEQRES  20 J  721  HIS ILE SER ILE CYS SER PRO GLN VAL ALA GLN LEU PHE          
SEQRES  21 J  721  THR ASP ASN PHE ASP TYR GLN THR ARG ASP ASP PHE VAL          
SEQRES  22 J  721  ARG GLY LEU LEU VAL ASN GLU GLU ILE LEU GLY ASN GLN          
SEQRES  23 J  721  ILE HIS MET HIS VAL THR ALA LYS GLU TYR GLY ALA ARG          
SEQRES  24 J  721  VAL SER ASN LEU HIS MET TYR SER ALA VAL CYS ALA ASP          
SEQRES  25 J  721  VAL ILE ARG ARG TRP VAL TYR PRO LEU THR PRO GLU ALA          
SEQRES  26 J  721  ASN PHE THR ASP SER THR THR GLN SER CYS THR HIS SER          
SEQRES  27 J  721  ARG HIS ASN ILE TYR ARG GLY PRO GLU VAL SER LEU GLY          
SEQRES  28 J  721  HIS GLY SER ILE LEU GLU GLU ASN VAL LEU LEU GLY SER          
SEQRES  29 J  721  GLY THR VAL ILE GLY SER ASN CYS PHE ILE THR ASN SER          
SEQRES  30 J  721  VAL ILE GLY PRO GLY CYS HIS ILE GLY ASP ASN VAL VAL          
SEQRES  31 J  721  LEU ASP GLN THR TYR LEU TRP GLN GLY VAL ARG VAL ALA          
SEQRES  32 J  721  ALA GLY ALA GLN ILE HIS GLN SER LEU LEU CYS ASP ASN          
SEQRES  33 J  721  ALA GLU VAL LYS GLU ARG VAL THR LEU LYS PRO ARG SER          
SEQRES  34 J  721  VAL LEU THR SER GLN VAL VAL VAL GLY PRO ASN ILE THR          
SEQRES  35 J  721  LEU PRO GLU GLY SER VAL ILE SER LEU HIS PRO PRO ASP          
SEQRES  36 J  721  ALA GLU GLU ASP GLU ASP ASP GLY GLU PHE SER ASP ASP          
SEQRES  37 J  721  SER GLY ALA ASP GLN GLU LYS ASP LYS VAL LYS MET LYS          
SEQRES  38 J  721  GLY TYR ASN PRO ALA GLU VAL GLY ALA ALA GLY LYS GLY          
SEQRES  39 J  721  TYR LEU TRP LYS ALA ALA GLY MET ASN MET GLU GLU GLU          
SEQRES  40 J  721  GLU GLU LEU GLN GLN ASN LEU TRP GLY LEU LYS ILE ASN          
SEQRES  41 J  721  MET GLU GLU GLU SER GLU SER GLU SER GLU GLN SER MET          
SEQRES  42 J  721  ASP SER GLU GLU PRO ASP SER ARG GLY GLY SER PRO GLN          
SEQRES  43 J  721  MET ASP ASP ILE LYS VAL PHE GLN ASN GLU VAL LEU GLY          
SEQRES  44 J  721  THR LEU GLN ARG GLY LYS GLU GLU ASN ILE SER CYS ASP          
SEQRES  45 J  721  ASN LEU VAL LEU GLU ILE ASN SER LEU LYS TYR ALA TYR          
SEQRES  46 J  721  ASN ILE SER LEU LYS GLU VAL MET GLN VAL LEU SER HIS          
SEQRES  47 J  721  VAL VAL LEU GLU PHE PRO LEU GLN GLN MET ASP SER PRO          
SEQRES  48 J  721  LEU ASP SER SER ARG TYR CYS ALA LEU LEU LEU PRO LEU          
SEQRES  49 J  721  LEU LYS ALA TRP SER PRO VAL PHE ARG ASN TYR ILE LYS          
SEQRES  50 J  721  ARG ALA ALA ASP HIS LEU GLU ALA LEU ALA ALA ILE GLU          
SEQRES  51 J  721  ASP PHE PHE LEU GLU HIS GLU ALA LEU GLY ILE SER MET          
SEQRES  52 J  721  ALA LYS VAL LEU MET ALA PHE TYR GLN LEU GLU ILE LEU          
SEQRES  53 J  721  ALA GLU GLU THR ILE LEU SER TRP PHE SER GLN ARG ASP          
SEQRES  54 J  721  THR THR ASP LYS GLY GLN GLN LEU ARG LYS ASN GLN GLN          
SEQRES  55 J  721  LEU GLN ARG PHE ILE GLN TRP LEU LYS GLU ALA GLU GLU          
SEQRES  56 J  721  GLU SER SER GLU ASP ASP                                      
SEQRES   1 K  315  MET PRO GLY LEU SER CYS ARG PHE TYR GLN HIS LYS PHE          
SEQRES   2 K  315  PRO GLU VAL GLU ASP VAL VAL MET VAL ASN VAL ARG SER          
SEQRES   3 K  315  ILE ALA GLU MET GLY ALA TYR VAL SER LEU LEU GLU TYR          
SEQRES   4 K  315  ASN ASN ILE GLU GLY MET ILE LEU LEU SER GLU LEU SER          
SEQRES   5 K  315  ARG ARG ARG ILE ARG SER ILE ASN LYS LEU ILE ARG ILE          
SEQRES   6 K  315  GLY ARG ASN GLU CYS VAL VAL VAL ILE ARG VAL ASP LYS          
SEQRES   7 K  315  GLU LYS GLY TYR ILE ASP LEU SER LYS ARG ARG VAL SER          
SEQRES   8 K  315  PRO GLU GLU ALA ILE LYS CYS GLU ASP LYS PHE THR LYS          
SEQRES   9 K  315  SER LYS THR VAL TYR SER ILE LEU ARG HIS VAL ALA GLU          
SEQRES  10 K  315  VAL LEU GLU TYR THR LYS ASP GLU GLN LEU GLU SER LEU          
SEQRES  11 K  315  PHE GLN ARG THR ALA TRP VAL PHE ASP ASP LYS TYR LYS          
SEQRES  12 K  315  ARG PRO GLY TYR GLY ALA TYR ASP ALA PHE LYS HIS ALA          
SEQRES  13 K  315  VAL SER ASP PRO SER ILE LEU ASP SER LEU ASP LEU ASN          
SEQRES  14 K  315  GLU ASP GLU ARG GLU VAL LEU ILE ASN ASN ILE ASN ARG          
SEQRES  15 K  315  ARG LEU THR PRO GLN ALA VAL LYS ILE ARG ALA ASP ILE          
SEQRES  16 K  315  GLU VAL ALA CYS TYR GLY TYR GLU GLY ILE ASP ALA VAL          
SEQRES  17 K  315  LYS GLU ALA LEU ARG ALA GLY LEU ASN CYS SER THR GLU          
SEQRES  18 K  315  ASN MET PRO ILE LYS ILE ASN LEU ILE ALA PRO PRO ARG          
SEQRES  19 K  315  TYR VAL MET THR THR THR THR LEU GLU ARG THR GLU GLY          
SEQRES  20 K  315  LEU SER VAL LEU SER GLN ALA MET ALA VAL ILE LYS GLU          
SEQRES  21 K  315  LYS ILE GLU GLU LYS ARG GLY VAL PHE ASN VAL GLN MET          
SEQRES  22 K  315  GLU PRO LYS VAL VAL THR ASP THR ASP GLU THR GLU LEU          
SEQRES  23 K  315  ALA ARG GLN MET GLU ARG LEU GLU ARG GLU ASN ALA GLU          
SEQRES  24 K  315  VAL ASP GLY ASP ASP ASP ALA GLU GLU MET GLU ALA LYS          
SEQRES  25 K  315  ALA GLU ASP                                                  
SEQRES   1 M  333  MET SER GLY ASP GLU MET ILE PHE ASP PRO THR MET SER          
SEQRES   2 M  333  LYS LYS LYS LYS LYS LYS LYS LYS PRO PHE MET LEU ASP          
SEQRES   3 M  333  GLU GLU GLY ASP THR GLN THR GLU GLU THR GLN PRO SER          
SEQRES   4 M  333  GLU THR LYS GLU VAL GLU PRO GLU PRO THR GLU ASP LYS          
SEQRES   5 M  333  ASP LEU GLU ALA ASP GLU GLU ASP THR ARG LYS LYS ASP          
SEQRES   6 M  333  ALA SER ASP ASP LEU ASP ASP LEU ASN PHE PHE ASN GLN          
SEQRES   7 M  333  LYS LYS LYS LYS LYS LYS THR LYS LYS ILE PHE ASP ILE          
SEQRES   8 M  333  ASP GLU ALA GLU GLU GLY VAL LYS ASP LEU LYS ILE GLU          
SEQRES   9 M  333  SER ASP VAL GLN GLU PRO THR GLU PRO GLU ASP ASP LEU          
SEQRES  10 M  333  ASP ILE MET LEU GLY ASN LYS LYS LYS LYS LYS LYS ASN          
SEQRES  11 M  333  VAL LYS PHE PRO ASP GLU ASP GLU ILE LEU GLU LYS ASP          
SEQRES  12 M  333  GLU ALA LEU GLU ASP GLU ASP ASN LYS LYS ASP ASP GLY          
SEQRES  13 M  333  ILE SER PHE SER ASN GLN THR GLY PRO ALA TRP ALA GLY          
SEQRES  14 M  333  SER GLU ARG ASP TYR THR TYR GLU GLU LEU LEU ASN ARG          
SEQRES  15 M  333  VAL PHE ASN ILE MET ARG GLU LYS ASN PRO ASP MET VAL          
SEQRES  16 M  333  ALA GLY GLU LYS ARG LYS PHE VAL MET LYS PRO PRO GLN          
SEQRES  17 M  333  VAL VAL ARG VAL GLY THR LYS LYS THR SER PHE VAL ASN          
SEQRES  18 M  333  PHE THR ASP ILE CYS LYS LEU LEU HIS ARG GLN PRO LYS          
SEQRES  19 M  333  HIS LEU LEU ALA PHE LEU LEU ALA GLU LEU GLY THR SER          
SEQRES  20 M  333  GLY SER ILE ASP GLY ASN ASN GLN LEU VAL ILE LYS GLY          
SEQRES  21 M  333  ARG PHE GLN GLN LYS GLN ILE GLU ASN VAL LEU ARG ARG          
SEQRES  22 M  333  TYR ILE LYS GLU TYR VAL THR CYS HIS THR CYS ARG SER          
SEQRES  23 M  333  PRO ASP THR ILE LEU GLN LYS ASP THR ARG LEU TYR PHE          
SEQRES  24 M  333  LEU GLN CYS GLU THR CYS HIS SER ARG CYS SER VAL ALA          
SEQRES  25 M  333  SER ILE LYS THR GLY PHE GLN ALA VAL THR GLY LYS ARG          
SEQRES  26 M  333  ALA GLN LEU ARG ALA LYS ALA ASN                              
SEQRES   1 P  472  MET ALA GLY GLY GLU ALA GLY VAL THR LEU GLY GLN PRO          
SEQRES   2 P  472  HIS LEU SER ARG GLN ASP LEU THR THR LEU ASP VAL THR          
SEQRES   3 P  472  LYS LEU THR PRO LEU SER HIS GLU VAL ILE SER ARG GLN          
SEQRES   4 P  472  ALA THR ILE ASN ILE GLY THR ILE GLY HIS VAL ALA HIS          
SEQRES   5 P  472  GLY LYS SER THR VAL VAL LYS ALA ILE SER GLY VAL HIS          
SEQRES   6 P  472  THR VAL ARG PHE LYS ASN GLU LEU GLU ARG ASN ILE THR          
SEQRES   7 P  472  ILE LYS LEU GLY TYR ALA ASN ALA LYS ILE TYR LYS LEU          
SEQRES   8 P  472  ASP ASP PRO SER CYS PRO ARG PRO GLU CYS TYR ARG SER          
SEQRES   9 P  472  CYS GLY SER SER THR PRO ASP GLU PHE PRO THR ASP ILE          
SEQRES  10 P  472  PRO GLY THR LYS GLY ASN PHE LYS LEU VAL ARG HIS VAL          
SEQRES  11 P  472  SER PHE VAL ASP CYS PRO GLY HIS ASP ILE LEU MET ALA          
SEQRES  12 P  472  THR MET LEU ASN GLY ALA ALA VAL MET ASP ALA ALA LEU          
SEQRES  13 P  472  LEU LEU ILE ALA GLY ASN GLU SER CYS PRO GLN PRO GLN          
SEQRES  14 P  472  THR SER GLU HIS LEU ALA ALA ILE GLU ILE MET LYS LEU          
SEQRES  15 P  472  LYS HIS ILE LEU ILE LEU GLN ASN LYS ILE ASP LEU VAL          
SEQRES  16 P  472  LYS GLU SER GLN ALA LYS GLU GLN TYR GLU GLN ILE LEU          
SEQRES  17 P  472  ALA PHE VAL GLN GLY THR VAL ALA GLU GLY ALA PRO ILE          
SEQRES  18 P  472  ILE PRO ILE SER ALA GLN LEU LYS TYR ASN ILE GLU VAL          
SEQRES  19 P  472  VAL CYS GLU TYR ILE VAL LYS LYS ILE PRO VAL PRO PRO          
SEQRES  20 P  472  ARG ASP PHE THR SER GLU PRO ARG LEU ILE VAL ILE ARG          
SEQRES  21 P  472  SER PHE ASP VAL ASN LYS PRO GLY CYS GLU VAL ASP ASP          
SEQRES  22 P  472  LEU LYS GLY GLY VAL ALA GLY GLY SER ILE LEU LYS GLY          
SEQRES  23 P  472  VAL LEU LYS VAL GLY GLN GLU ILE GLU VAL ARG PRO GLY          
SEQRES  24 P  472  ILE VAL SER LYS ASP SER GLU GLY LYS LEU MET CYS LYS          
SEQRES  25 P  472  PRO ILE PHE SER LYS ILE VAL SER LEU PHE ALA GLU HIS          
SEQRES  26 P  472  ASN ASP LEU GLN TYR ALA ALA PRO GLY GLY LEU ILE GLY          
SEQRES  27 P  472  VAL GLY THR LYS ILE ASP PRO THR LEU CYS ARG ALA ASP          
SEQRES  28 P  472  ARG MET VAL GLY GLN VAL LEU GLY ALA VAL GLY ALA LEU          
SEQRES  29 P  472  PRO GLU ILE PHE THR GLU LEU GLU ILE SER TYR PHE LEU          
SEQRES  30 P  472  LEU ARG ARG LEU LEU GLY VAL ARG THR GLU GLY ASP LYS          
SEQRES  31 P  472  LYS ALA ALA LYS VAL GLN LYS LEU SER LYS ASN GLU VAL          
SEQRES  32 P  472  LEU MET VAL ASN ILE GLY SER LEU SER THR GLY GLY ARG          
SEQRES  33 P  472  VAL SER ALA VAL LYS ALA ASP LEU GLY LYS ILE VAL LEU          
SEQRES  34 P  472  THR ASN PRO VAL CYS THR GLU VAL GLY GLU LYS ILE ALA          
SEQRES  35 P  472  LEU SER ARG ARG VAL GLU LYS HIS TRP ARG LEU ILE GLY          
SEQRES  36 P  472  TRP GLY GLN ILE ARG ARG GLY VAL THR ILE LYS PRO THR          
SEQRES  37 P  472  VAL ASP ASP ASP                                              
HELIX    1 AA1 ILE A    7  ASP A   17  1                                  11    
HELIX    2 AA2 ALA A   21  PHE A   33  1                                  13    
HELIX    3 AA3 LEU A   34  ARG A   36  5                                   3    
HELIX    4 AA4 ARG A   46  GLY A   58  1                                  13    
HELIX    5 AA5 VAL A   63  SER A   77  1                                  15    
HELIX    6 AA6 ILE A   92  LEU A  106  1                                  15    
HELIX    7 AA7 LEU A  106  CYS A  115  1                                  10    
HELIX    8 AA8 SER A  131  ALA A  143  1                                  13    
HELIX    9 AA9 GLY A  161  HIS A  170  1                                  10    
HELIX   10 AB1 ALA A  182  MET A  187  1                                   6    
HELIX   11 AB2 GLU A  188  ALA A  190  5                                   3    
HELIX   12 AB3 THR A  212  ASN A  223  1                                  12    
HELIX   13 AB4 ASN A  242  VAL A  246  5                                   5    
HELIX   14 AB5 SER A  294  LEU A  303  1                                  10    
HELIX   15 AB6 GLU B    5  ASP B   17  1                                  13    
HELIX   16 AB7 ALA B   21  GLU B   32  1                                  12    
HELIX   17 AB8 PHE B   33  ARG B   36  5                                   4    
HELIX   18 AB9 ARG B   46  GLY B   58  1                                  13    
HELIX   19 AC1 SER B   62  ILE B   76  1                                  15    
HELIX   20 AC2 ILE B   92  HIS B  116  1                                  25    
HELIX   21 AC3 SER B  131  ALA B  141  1                                  11    
HELIX   22 AC4 GLY B  161  HIS B  170  1                                  10    
HELIX   23 AC5 LEU B  179  VAL B  183  5                                   5    
HELIX   24 AC6 ILE B  186  ALA B  190  5                                   5    
HELIX   25 AC7 THR B  212  ALA B  221  1                                  10    
HELIX   26 AC8 PRO B  247  TYR B  252  1                                   6    
HELIX   27 AC9 ALA B  295  ILE B  301  1                                   7    
HELIX   28 AD1 LEU C   11  ARG C   24  1                                  14    
HELIX   29 AD2 SER C   31  ARG C   43  1                                  13    
HELIX   30 AD3 ASN C   53  GLN C   72  1                                  20    
HELIX   31 AD4 THR C   76  GLY C   98  1                                  23    
HELIX   32 AD5 GLN C  128  GLN C  154  1                                  27    
HELIX   33 AD6 ALA C  155  HIS C  158  5                                   4    
HELIX   34 AD7 SER C  171  ARG C  185  1                                  15    
HELIX   35 AD8 GLY C  200  LEU C  207  1                                   8    
HELIX   36 AD9 ALA C  221  ARG C  228  5                                   8    
HELIX   37 AE1 GLY C  250  ALA C  258  1                                   9    
HELIX   38 AE2 ILE C  336  TYR C  344  1                                   9    
HELIX   39 AE3 HIS C  345  VAL C  350  5                                   6    
HELIX   40 AE4 LEU D   11  LEU D   22  1                                  12    
HELIX   41 AE5 SER D   31  LEU D   41  1                                  11    
HELIX   42 AE6 ASN D   53  GLN D   72  1                                  20    
HELIX   43 AE7 VAL D   78  GLY D   98  1                                  21    
HELIX   44 AE8 GLN D  128  GLN D  154  1                                  27    
HELIX   45 AE9 SER D  171  ARG D  185  1                                  15    
HELIX   46 AF1 GLY D  200  LEU D  207  1                                   8    
HELIX   47 AF2 THR D  218  ILE D  222  5                                   5    
HELIX   48 AF3 GLY D  250  LYS D  259  1                                  10    
HELIX   49 AF4 ALA D  290  VAL D  294  5                                   5    
HELIX   50 AF5 PRO D  317  ILE D  321  5                                   5    
HELIX   51 AF6 ILE D  336  LEU D  343  1                                   8    
HELIX   52 AF7 HIS D  345  HIS D  349  5                                   5    
HELIX   53 AF8 ILE E   36  LEU E   43  1                                   8    
HELIX   54 AF9 ALA E   62  GLU E   66  5                                   5    
HELIX   55 AG1 GLY E   85  ILE E   93  1                                   9    
HELIX   56 AG2 ASP E  119  ALA E  123  5                                   5    
HELIX   57 AG3 ASN E  172  LEU E  176  5                                   5    
HELIX   58 AG4 LYS E  183  HIS E  190  1                                   8    
HELIX   59 AG5 LYS E  208  GLU E  217  1                                  10    
HELIX   60 AG6 ARG E  225  ILE E  229  5                                   5    
HELIX   61 AG7 TRP F   37  ASN F   41  5                                   5    
HELIX   62 AG8 ALA F   62  GLU F   66  5                                   5    
HELIX   63 AG9 GLY F   85  ARG F   91  1                                   7    
HELIX   64 AH1 GLU F  116  LEU F  120  5                                   5    
HELIX   65 AH2 GLY F  184  HIS F  190  1                                   7    
HELIX   66 AH3 LYS F  208  MET F  216  1                                   9    
HELIX   67 AH4 SER G  191  PHE G  195  5                                   5    
HELIX   68 AH5 HIS G  204  SER G  215  1                                  12    
HELIX   69 AH6 ASN G  223  GLN G  238  1                                  16    
HELIX   70 AH7 ASP G  251  LEU G  256  1                                   6    
HELIX   71 AH8 LEU G  256  ARG G  267  1                                  12    
HELIX   72 AH9 SER G  270  VAL G  287  1                                  18    
HELIX   73 AI1 ARG G  292  ILE G  327  1                                  36    
HELIX   74 AI2 LEU G  341  THR G  351  1                                  11    
HELIX   75 AI3 GLY G  369  ALA G  379  1                                  11    
HELIX   76 AI4 PRO G  389  VAL G  394  5                                   6    
HELIX   77 AI5 ALA G  421  ALA G  427  1                                   7    
HELIX   78 AI6 GLU G  439  PHE G  443  5                                   5    
HELIX   79 AI7 VAL G  512  ARG G  517  1                                   6    
HELIX   80 AI8 SER H  191  PHE H  195  5                                   5    
HELIX   81 AI9 HIS H  204  SER H  215  1                                  12    
HELIX   82 AJ1 ASN H  223  GLN H  238  1                                  16    
HELIX   83 AJ2 LEU H  252  ARG H  267  1                                  16    
HELIX   84 AJ3 SER H  270  VAL H  287  1                                  18    
HELIX   85 AJ4 ARG H  292  ILE H  327  1                                  36    
HELIX   86 AJ5 LEU H  341  THR H  351  1                                  11    
HELIX   87 AJ6 GLY H  369  ALA H  379  1                                  11    
HELIX   88 AJ7 LEU H  387  ALA H  391  5                                   5    
HELIX   89 AJ8 ALA H  421  ALA H  429  1                                   9    
HELIX   90 AJ9 VAL H  512  VAL H  518  1                                   7    
HELIX   91 AK1 PRO I   64  LEU I   68  5                                   5    
HELIX   92 AK2 ALA I   74  THR I   86  1                                  13    
HELIX   93 AK3 LYS I   98  LEU I  107  1                                  10    
HELIX   94 AK4 GLY I  132  ALA I  142  1                                  11    
HELIX   95 AK5 ILE I  161  LYS I  176  1                                  16    
HELIX   96 AK6 PRO I  254  PHE I  260  1                                   7    
HELIX   97 AK7 ARG I  269  GLY I  275  1                                   7    
HELIX   98 AK8 LEU I  276  VAL I  278  5                                   3    
HELIX   99 AK9 ASN I  302  ILE I  314  1                                  13    
HELIX  100 AL1 SER I  338  ILE I  342  5                                   5    
HELIX  101 AL2 ALA J   74  THR J   86  1                                  13    
HELIX  102 AL3 LYS J   98  LEU J  106  1                                   9    
HELIX  103 AL4 SER J  130  ASP J  139  1                                  10    
HELIX  104 AL5 ILE J  161  GLU J  175  1                                  15    
HELIX  105 AL6 PRO J  227  PHE J  231  5                                   5    
HELIX  106 AL7 PRO J  254  ASP J  262  1                                   9    
HELIX  107 AL8 THR J  268  LEU J  277  1                                  10    
HELIX  108 AL9 ASN J  302  ALA J  311  1                                  10    
HELIX  109 AM1 ASP J  548  VAL J  552  1                                   5    
HELIX  110 AM2 VAL J  552  LEU J  561  1                                  10    
HELIX  111 AM3 GLN J  562  LYS J  565  5                                   4    
HELIX  112 AM4 CYS J  571  ALA J  584  1                                  14    
HELIX  113 AM5 SER J  588  GLU J  602  1                                  15    
HELIX  114 AM6 SER J  614  LEU J  622  1                                   9    
HELIX  115 AM7 LEU J  622  ALA J  627  1                                   6    
HELIX  116 AM8 ARG J  638  HIS J  656  1                                  19    
HELIX  117 AM9 GLU J  657  ALA J  664  5                                   8    
HELIX  118 AN1 VAL J  666  PHE J  670  5                                   5    
HELIX  119 AN2 ALA J  677  PHE J  685  1                                   9    
HELIX  120 AN3 LYS J  693  LYS J  699  1                                   7    
HELIX  121 AN4 ASN J  700  GLU J  714  1                                  15    
HELIX  122 AN5 ILE K   96  HIS K  114  1                                  19    
HELIX  123 AN6 GLN K  126  GLN K  132  1                                   7    
HELIX  124 AN7 ARG K  133  ALA K  135  5                                   3    
HELIX  125 AN8 LYS K  143  ALA K  156  1                                  14    
HELIX  126 AN9 GLU K  172  ASN K  178  1                                   7    
HELIX  127 AO1 ASN K  178  ARG K  183  1                                   6    
HELIX  128 AO2 TYR K  202  GLU K  221  1                                  20    
HELIX  129 AO3 THR K  245  LYS K  261  1                                  17    
HELIX  130 AO4 TYR M  174  MET M  187  1                                  14    
HELIX  131 AO5 GLY P   53  GLY P   63  1                                  11    
HELIX  132 AO6 MET P  142  ALA P  149  1                                   8    
HELIX  133 AO7 PRO P  168  LEU P  174  1                                   7    
HELIX  134 AO8 LYS P  196  ALA P  209  1                                  14    
HELIX  135 AO9 ASN P  231  LYS P  241  1                                  11    
SHEET    1 AA1 2 THR A 124  THR A 127  0                                        
SHEET    2 AA1 2 SER A 149  VAL A 152  1  O  TYR A 151   N  THR A 127           
SHEET    1 AA2 3 GLY A 199  VAL A 201  0                                        
SHEET    2 AA2 3 GLY A 205  LYS A 209 -1  O  ILE A 207   N  GLY A 199           
SHEET    3 AA2 3 VAL A 273  ASP A 274 -1  O  ASP A 274   N  ASN A 208           
SHEET    1 AA3 2 LEU A 284  PHE A 285  0                                        
SHEET    2 AA3 2 VAL A 290  LEU A 291 -1  O  LEU A 291   N  LEU A 284           
SHEET    1 AA4 4 TYR B 151  VAL B 152  0                                        
SHEET    2 AA4 4 ILE B 125  THR B 127  1  N  ILE B 125   O  TYR B 151           
SHEET    3 AA4 4 LEU B 192  GLY B 196  1  O  LEU B 192   N  LEU B 126           
SHEET    4 AA4 4 PHE B 226  VAL B 229  1  O  VAL B 229   N  VAL B 195           
SHEET    1 AA5 2 GLY B 199  VAL B 200  0                                        
SHEET    2 AA5 2 ILE B 206  ILE B 207 -1  O  ILE B 207   N  GLY B 199           
SHEET    1 AA6 2 LEU B 284  PHE B 285  0                                        
SHEET    2 AA6 2 VAL B 290  LEU B 291 -1  O  LEU B 291   N  LEU B 284           
SHEET    1 AA7 4 VAL C 164  ILE C 168  0                                        
SHEET    2 AA7 4 HIS C 188  ALA C 192  1  O  ILE C 190   N  ILE C 165           
SHEET    3 AA7 4 THR C 214  VAL C 216  1  O  THR C 215   N  VAL C 191           
SHEET    4 AA7 4 ARG G 483  LEU G 484  1  O  ARG G 483   N  THR C 214           
SHEET    1 AA8 6 PHE C 313  VAL C 316  0                                        
SHEET    2 AA8 6 LEU C 245  VAL C 248 -1  N  ALA C 247   O  ASP C 314           
SHEET    3 AA8 6 ILE C 234  ILE C 239 -1  N  THR C 238   O  ARG C 246           
SHEET    4 AA8 6 ILE C 266  CYS C 268  1  O  ILE C 266   N  ILE C 234           
SHEET    5 AA8 6 LEU C 323  SER C 326  1  O  ILE C 325   N  VAL C 267           
SHEET    6 AA8 6 GLY C 329  ASN C 331 -1  O  ASN C 331   N  PHE C 324           
SHEET    1 AA9 7 VAL C 306  VAL C 308  0                                        
SHEET    2 AA9 7 ALA G 383  LEU G 387  1  O  TYR G 385   N  SER C 307           
SHEET    3 AA9 7 VAL G 358  ASP G 362  1  N  VAL G 360   O  SER G 384           
SHEET    4 AA9 7 ILE G 333  TYR G 336  1  N  VAL G 335   O  VAL G 359           
SHEET    5 AA9 7 LYS G 400  LEU G 403  1  O  LEU G 402   N  LEU G 334           
SHEET    6 AA9 7 VAL G 434  CYS G 437  1  O  LEU G 435   N  LEU G 403           
SHEET    7 AA9 7 LEU G 499  ILE G 501  1  O  LEU G 499   N  VAL G 436           
SHEET    1 AB1 6 THR D 215  VAL D 216  0                                        
SHEET    2 AB1 6 HIS D 188  ALA D 192  1  N  VAL D 189   O  THR D 215           
SHEET    3 AB1 6 VAL D 164  ILE D 168  1  N  ILE D 165   O  ILE D 190           
SHEET    4 AB1 6 VAL D 232  GLY D 235  1  O  ILE D 233   N  MET D 166           
SHEET    5 AB1 6 LEU D 265  CYS D 268  1  O  ILE D 266   N  ILE D 234           
SHEET    6 AB1 6 LEU D 323  ILE D 325  1  O  LEU D 323   N  VAL D 267           
SHEET    1 AB2 2 THR D 238  ILE D 239  0                                        
SHEET    2 AB2 2 LEU D 245  ARG D 246 -1  O  ARG D 246   N  THR D 238           
SHEET    1 AB3 6 VAL E  51  ILE E  52  0                                        
SHEET    2 AB3 6 GLN E   4  VAL E   6  1  N  ALA E   5   O  ILE E  52           
SHEET    3 AB3 6 VAL E 101  VAL E 103  1  O  LEU E 102   N  VAL E   6           
SHEET    4 AB3 6 TYR E 205  LEU E 207 -1  O  LEU E 207   N  VAL E 101           
SHEET    5 AB3 6 LEU E 128  ALA E 129 -1  N  ALA E 129   O  CYS E 206           
SHEET    6 AB3 6 ILE E 263  TYR E 264  1  O  TYR E 264   N  LEU E 128           
SHEET    1 AB4 3 MET E 170  ALA E 171  0                                        
SHEET    2 AB4 3 PHE E 157  VAL E 160 -1  N  PHE E 157   O  ALA E 171           
SHEET    3 AB4 3 ARG E 194  HIS E 196 -1  O  HIS E 196   N  ILE E 158           
SHEET    1 AB5 2 VAL E 181  ILE E 182  0                                        
SHEET    2 AB5 2 PHE J 224  ALA J 225 -1  O  PHE J 224   N  ILE E 182           
SHEET    1 AB6 4 LEU E 357  ILE E 358  0                                        
SHEET    2 AB6 4 VAL E 374  ILE E 375  1  O  ILE E 375   N  LEU E 357           
SHEET    3 AB6 4 LEU E 391  LEU E 392  1  O  LEU E 392   N  VAL E 374           
SHEET    4 AB6 4 VAL E 408  ILE E 409  1  O  ILE E 409   N  LEU E 391           
SHEET    1 AB7 3 ILE F  52  VAL F  53  0                                        
SHEET    2 AB7 3 VAL F   6  VAL F   7  1  N  VAL F   7   O  ILE F  52           
SHEET    3 AB7 3 VAL F 103  LEU F 104  1  O  LEU F 104   N  VAL F   6           
SHEET    1 AB8 2 MET F 132  ARG F 133  0                                        
SHEET    2 AB8 2 VAL F 200  ASP F 201 -1  O  VAL F 200   N  ARG F 133           
SHEET    1 AB9 4 GLY F 159  VAL F 160  0                                        
SHEET    2 AB9 4 ILE F 193  PHE F 195 -1  O  ARG F 194   N  VAL F 160           
SHEET    3 AB9 4 VAL I 238  ARG I 241 -1  O  VAL I 240   N  ILE F 193           
SHEET    4 AB9 4 VAL I 203  ASP I 206 -1  N  VAL I 205   O  GLU I 239           
SHEET    1 AC1 2 VAL F 181  LYS F 183  0                                        
SHEET    2 AC1 2 ARG I 223  ALA I 225 -1  O  PHE I 224   N  ILE F 182           
SHEET    1 AC2 3 GLN F 363  ILE F 364  0                                        
SHEET    2 AC2 3 LEU F 380  ILE F 381  1  O  ILE F 381   N  GLN F 363           
SHEET    3 AC2 3 THR F 397  VAL F 398  1  O  VAL F 398   N  LEU F 380           
SHEET    1 AC3 2 SER F 402  ILE F 404  0                                        
SHEET    2 AC3 2 ALA F 419  ILE F 421  1  O  ILE F 421   N  ASN F 403           
SHEET    1 AC4 2 VAL G 414  ARG G 417  0                                        
SHEET    2 AC4 2 TYR G 489  THR G 492 -1  O  ASP G 490   N  SER G 416           
SHEET    1 AC5 2 ILE H 333  LEU H 334  0                                        
SHEET    2 AC5 2 LYS H 400  VAL H 401  1  O  LYS H 400   N  LEU H 334           
SHEET    1 AC6 2 VAL H 358  VAL H 360  0                                        
SHEET    2 AC6 2 ALA H 383  TYR H 385  1  O  SER H 384   N  VAL H 358           
SHEET    1 AC7 3 ALA H 407  LEU H 408  0                                        
SHEET    2 AC7 3 VAL H 414  SER H 416 -1  O  MET H 415   N  ALA H 407           
SHEET    3 AC7 3 ASP H 490  THR H 492 -1  O  ASP H 490   N  SER H 416           
SHEET    1 AC8 3 VAL H 436  CYS H 437  0                                        
SHEET    2 AC8 3 LEU H 499  THR H 502  1  O  LEU H 499   N  VAL H 436           
SHEET    3 AC8 3 GLY H 505  PRO H 508 -1  O  GLY H 505   N  THR H 502           
SHEET    1 AC9 2 VAL I  46  VAL I  48  0                                        
SHEET    2 AC9 2 LEU I 150  TYR I 152  1  O  VAL I 151   N  VAL I  48           
SHEET    1 AD1 2 PHE I  94  CYS I  95  0                                        
SHEET    2 AD1 2 ILE I 123  THR I 124  1  O  ILE I 123   N  CYS I  95           
SHEET    1 AD2 2 SER I 179  PHE I 185  0                                        
SHEET    2 AD2 2 GLN I 286  VAL I 291  1  O  HIS I 290   N  MET I 183           
SHEET    1 AD3 2 VAL I 390  ASP I 392  0                                        
SHEET    2 AD3 2 GLN I 407  HIS I 409  1  O  ILE I 408   N  VAL I 390           
SHEET    1 AD4 2 LEU I 431  THR I 432  0                                        
SHEET    2 AD4 2 ILE I 449  SER I 450  1  O  ILE I 449   N  THR I 432           
SHEET    1 AD5 5 VAL J 119  ARG J 121  0                                        
SHEET    2 AD5 5 GLU J  90  VAL J  93  1  N  VAL J  93   O  ARG J 121           
SHEET    3 AD5 5 GLN J  44  VAL J  48  1  N  LEU J  47   O  PHE J  92           
SHEET    4 AD5 5 PHE J 148  TYR J 152  1  O  LEU J 149   N  VAL J  46           
SHEET    5 AD5 5 ILE J 251  CYS J 252 -1  O  CYS J 252   N  PHE J 148           
SHEET    1 AD6 2 VAL J 155  SER J 157  0                                        
SHEET    2 AD6 2 GLY J 297  ARG J 299 -1  O  ALA J 298   N  ILE J 156           
SHEET    1 AD7 2 SER J 179  ILE J 184  0                                        
SHEET    2 AD7 2 GLN J 286  HIS J 290  1  O  HIS J 288   N  MET J 181           
SHEET    1 AD8 3 VAL J 212  HIS J 214  0                                        
SHEET    2 AD8 3 VAL J 203  VAL J 205 -1  N  ALA J 204   O  LEU J 213           
SHEET    3 AD8 3 GLU J 239  ARG J 241 -1  O  ARG J 241   N  VAL J 203           
SHEET    1 AD9 2 THR J 336  HIS J 337  0                                        
SHEET    2 AD9 2 TYR J 343  ARG J 344 -1  O  ARG J 344   N  THR J 336           
SHEET    1 AE1 2 ILE J 355  LEU J 356  0                                        
SHEET    2 AE1 2 PHE J 373  ILE J 374  1  O  ILE J 374   N  ILE J 355           
SHEET    1 AE2 2 VAL J 389  VAL J 390  0                                        
SHEET    2 AE2 2 ALA J 406  GLN J 407  1  O  ALA J 406   N  VAL J 390           
SHEET    1 AE3 2 SER J 411  LEU J 412  0                                        
SHEET    2 AE3 2 SER J 429  VAL J 430  1  O  SER J 429   N  LEU J 412           
SHEET    1 AE4 2 VAL K  22  ASN K  23  0                                        
SHEET    2 AE4 2 ASN K  68  GLU K  69 -1  O  GLU K  69   N  VAL K  22           
SHEET    1 AE5 2 ILE P  44  GLY P  45  0                                        
SHEET    2 AE5 2 ALA P 154  ALA P 155  1  O  ALA P 154   N  GLY P  45           
SHEET    1 AE6 2 ILE P 159  ALA P 160  0                                        
SHEET    2 AE6 2 GLN P 189  ASN P 190  1  O  ASN P 190   N  ILE P 159           
SHEET    1 AE7 3 GLY P 277  VAL P 278  0                                        
SHEET    2 AE7 3 VAL P 339  THR P 341 -1  O  THR P 341   N  GLY P 277           
SHEET    3 AE7 3 ILE P 318  LEU P 321 -1  N  VAL P 319   O  GLY P 340           
SHEET    1 AE8 4 ALA P 419  VAL P 420  0                                        
SHEET    2 AE8 4 LEU P 424  LYS P 426 -1  O  LYS P 426   N  ALA P 419           
SHEET    3 AE8 4 GLU P 372  PHE P 376 -1  N  ILE P 373   O  GLY P 425           
SHEET    4 AE8 4 TRP P 456  ILE P 459 -1  O  GLN P 458   N  SER P 374           
SHEET    1 AE9 4 GLY P 414  GLY P 415  0                                        
SHEET    2 AE9 4 LEU P 404  ASN P 407 -1  N  LEU P 404   O  GLY P 415           
SHEET    3 AE9 4 ALA P 442  ARG P 446 -1  O  SER P 444   N  MET P 405           
SHEET    4 AE9 4 TRP P 451  LEU P 453 -1  O  ARG P 452   N  ARG P 445           
CISPEP   1 GLY C   27    PRO C   28          0        -3.34                     
CISPEP   2 GLY D   27    PRO D   28          0         0.83                     
CISPEP   3 ARG G  364    PRO G  365          0        -7.66                     
CISPEP   4 ARG H  364    PRO H  365          0         8.45                     
CISPEP   5 TYR I  319    PRO I  320          0         3.85                     
CISPEP   6 PHE J   57    PRO J   58          0       -11.66                     
CISPEP   7 TYR J  319    PRO J  320          0        15.49                     
CISPEP   8 SER J  610    PRO J  611          0        -7.85                     
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1           1          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      1.000000  0.000000  0.000000        0.00000                         
SCALE2      0.000000  1.000000  0.000000        0.00000                         
SCALE3      0.000000  0.000000  1.000000        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
DBGET integrated database retrieval system