HEADER HYDROLASE 04-SEP-18 6MDM
TITLE THE 20S SUPERCOMPLEX ENGAGING THE SNAP-25 N-TERMINUS (CLASS 1)
COMPND MOL_ID: 1;
COMPND 2 MOLECULE: VESICLE-FUSING ATPASE;
COMPND 3 CHAIN: A, B, C, D, E, F;
COMPND 4 SYNONYM: N-ETHYLMALEIMIDE-SENSITIVE FUSION PROTEIN,NEM-SENSITIVE
COMPND 5 FUSION PROTEIN,VESICULAR-FUSION PROTEIN NSF;
COMPND 6 EC: 3.6.4.6;
COMPND 7 ENGINEERED: YES;
COMPND 8 MOL_ID: 2;
COMPND 9 MOLECULE: SYNAPTOSOMAL-ASSOCIATED PROTEIN 25;
COMPND 10 CHAIN: H;
COMPND 11 SYNONYM: SNAP-25,SUPER PROTEIN,SUP,SYNAPTOSOMAL-ASSOCIATED 25 KDA
COMPND 12 PROTEIN;
COMPND 13 ENGINEERED: YES;
COMPND 14 MOL_ID: 3;
COMPND 15 MOLECULE: SYNTAXIN-1A;
COMPND 16 CHAIN: I;
COMPND 17 SYNONYM: NEURON-SPECIFIC ANTIGEN HPC-1,SYNAPTOTAGMIN-ASSOCIATED 35
COMPND 18 KDA PROTEIN,P35A;
COMPND 19 ENGINEERED: YES;
COMPND 20 MOL_ID: 4;
COMPND 21 MOLECULE: VESICLE-ASSOCIATED MEMBRANE PROTEIN 2;
COMPND 22 CHAIN: J;
COMPND 23 SYNONYM: VAMP-2,SYNAPTOBREVIN-2;
COMPND 24 ENGINEERED: YES;
COMPND 25 MOL_ID: 5;
COMPND 26 MOLECULE: ALPHA-SOLUBLE NSF ATTACHMENT PROTEIN;
COMPND 27 CHAIN: K, L;
COMPND 28 SYNONYM: SNAP-ALPHA,N-ETHYLMALEIMIDE-SENSITIVE FACTOR ATTACHMENT
COMPND 29 PROTEIN ALPHA;
COMPND 30 ENGINEERED: YES
SOURCE MOL_ID: 1;
SOURCE 2 ORGANISM_SCIENTIFIC: CRICETULUS GRISEUS;
SOURCE 3 ORGANISM_COMMON: CHINESE HAMSTER;
SOURCE 4 ORGANISM_TAXID: 10029;
SOURCE 5 GENE: NSF;
SOURCE 6 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE 7 EXPRESSION_SYSTEM_TAXID: 562;
SOURCE 8 MOL_ID: 2;
SOURCE 9 ORGANISM_SCIENTIFIC: RATTUS NORVEGICUS;
SOURCE 10 ORGANISM_COMMON: RAT;
SOURCE 11 ORGANISM_TAXID: 10116;
SOURCE 12 GENE: SNAP25, SNAP;
SOURCE 13 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE 14 EXPRESSION_SYSTEM_TAXID: 562;
SOURCE 15 MOL_ID: 3;
SOURCE 16 ORGANISM_SCIENTIFIC: RATTUS NORVEGICUS;
SOURCE 17 ORGANISM_COMMON: RAT;
SOURCE 18 ORGANISM_TAXID: 10116;
SOURCE 19 GENE: STX1A, SAP;
SOURCE 20 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE 21 EXPRESSION_SYSTEM_TAXID: 562;
SOURCE 22 MOL_ID: 4;
SOURCE 23 ORGANISM_SCIENTIFIC: RATTUS NORVEGICUS;
SOURCE 24 ORGANISM_COMMON: RAT;
SOURCE 25 ORGANISM_TAXID: 10116;
SOURCE 26 GENE: VAMP2, SYB2;
SOURCE 27 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE 28 EXPRESSION_SYSTEM_TAXID: 562;
SOURCE 29 MOL_ID: 5;
SOURCE 30 ORGANISM_SCIENTIFIC: RATTUS NORVEGICUS;
SOURCE 31 ORGANISM_COMMON: RAT;
SOURCE 32 ORGANISM_TAXID: 10116;
SOURCE 33 GENE: NAPA, SNAP, SNAPA;
SOURCE 34 EXPRESSION_SYSTEM: ESCHERICHIA COLI;
SOURCE 35 EXPRESSION_SYSTEM_TAXID: 562
KEYWDS SNARE, NSF, SNAP, ATPASE, AAA, DISASSEMBLY, SYNAPSE, MEMBRANE FUSION,
KEYWDS 2 EXOCYTOSIS, HYDROLASE
EXPDTA ELECTRON MICROSCOPY
AUTHOR K.I.WHITE,M.ZHAO,A.T.BRUNGER
REVDAT 3 18-DEC-19 6MDM 1 SCALE
REVDAT 2 26-SEP-18 6MDM 1 JRNL
REVDAT 1 19-SEP-18 6MDM 0
JRNL AUTH K.I.WHITE,M.ZHAO,U.B.CHOI,R.A.PFUETZNER,A.T.BRUNGER
JRNL TITL STRUCTURAL PRINCIPLES OF SNARE COMPLEX RECOGNITION BY THE
JRNL TITL 2 AAA+ PROTEIN NSF.
JRNL REF ELIFE V. 7 2018
JRNL REFN ESSN 2050-084X
JRNL PMID 30198481
JRNL DOI 10.7554/ELIFE.38888
REMARK 2
REMARK 2 RESOLUTION. 4.40 ANGSTROMS.
REMARK 3
REMARK 3 REFINEMENT.
REMARK 3 SOFTWARE PACKAGES : SERIALEM, RELION, PHENIX, COOT, PHENIX,
REMARK 3 COOT, RELION, RELION, RELION, RELION
REMARK 3 RECONSTRUCTION SCHEMA : NULL
REMARK 3
REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT
REMARK 3 PDB ENTRY : 3J96
REMARK 3 REFINEMENT SPACE : REAL
REMARK 3 REFINEMENT PROTOCOL : RIGID BODY FIT
REMARK 3 REFINEMENT TARGET : NULL
REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL
REMARK 3
REMARK 3 FITTING PROCEDURE : NULL
REMARK 3
REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS
REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL
REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL
REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 4.400
REMARK 3 NUMBER OF PARTICLES : 55150
REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE
REMARK 3 CORRECTION
REMARK 3
REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL
REMARK 3
REMARK 3 OTHER DETAILS: NULL
REMARK 4
REMARK 4 6MDM COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 06-SEP-18.
REMARK 100 THE DEPOSITION ID IS D_1000236719.
REMARK 245
REMARK 245 EXPERIMENTAL DETAILS
REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE
REMARK 245 SPECIMEN TYPE : NULL
REMARK 245
REMARK 245 ELECTRON MICROSCOPE SAMPLE
REMARK 245 SAMPLE TYPE : PARTICLE
REMARK 245 PARTICLE TYPE : POINT
REMARK 245 NAME OF SAMPLE : 20S SUPERCOMPLEX CONSISTING OF
REMARK 245 SOLUBLE NEURONAL SNARE COMPLEX,
REMARK 245 ALPHA-SNAP, AND N-
REMARK 245 ETHYLMALEIMIDE SENSITIVE FACTOR
REMARK 245 (NSF); N-ETHYLMALEIMIDE
REMARK 245 SENSITIVE FACTOR; SYNAPTOSOMAL-
REMARK 245 ASSOCIATED PROTEIN 25; SYNTAXIN-
REMARK 245 1A; VESICLE-ASSOCIATED MEMBRANE
REMARK 245 PROTEIN 2; ALPHA-SOLUBLE NSF
REMARK 245 ATTACHMENT PROTEIN
REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : 15.00
REMARK 245 SAMPLE SUPPORT DETAILS : NOT AVAILABLE
REMARK 245 SAMPLE VITRIFICATION DETAILS : BLOT FOR 3.5 SECONDS BEFORE
REMARK 245 PLUNGING.
REMARK 245 SAMPLE BUFFER : NULL
REMARK 245 PH : 8.00
REMARK 245 SAMPLE DETAILS : NULL
REMARK 245
REMARK 245 DATA ACQUISITION
REMARK 245 DATE OF EXPERIMENT : NULL
REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : 5418
REMARK 245 TEMPERATURE (KELVIN) : NULL
REMARK 245 MICROSCOPE MODEL : FEI TITAN KRIOS
REMARK 245 DETECTOR TYPE : GATAN K2 SUMMIT (4K X 4K)
REMARK 245 MINIMUM DEFOCUS (NM) : 1500.00
REMARK 245 MAXIMUM DEFOCUS (NM) : 3000.00
REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL
REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL
REMARK 245 NOMINAL CS : 2.70
REMARK 245 IMAGING MODE : BRIGHT FIELD
REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 58.00
REMARK 245 ILLUMINATION MODE : FLOOD BEAM
REMARK 245 NOMINAL MAGNIFICATION : NULL
REMARK 245 CALIBRATED MAGNIFICATION : NULL
REMARK 245 SOURCE : FIELD EMISSION GUN
REMARK 245 ACCELERATION VOLTAGE (KV) : 300
REMARK 245 IMAGING DETAILS : NULL
REMARK 247
REMARK 247 ELECTRON MICROSCOPY
REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON
REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE
REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES
REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION
REMARK 247 OF THE STRUCTURE FACTORS.
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: UNDECAMERIC
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E, F, H, I, J, K,
REMARK 350 AND CHAINS: L
REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000
REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000
REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465 M RES C SSSEQI
REMARK 465 MET A -23
REMARK 465 GLY A -22
REMARK 465 HIS A -21
REMARK 465 HIS A -20
REMARK 465 HIS A -19
REMARK 465 HIS A -18
REMARK 465 HIS A -17
REMARK 465 HIS A -16
REMARK 465 ASP A -15
REMARK 465 TYR A -14
REMARK 465 ASP A -13
REMARK 465 ILE A -12
REMARK 465 PRO A -11
REMARK 465 THR A -10
REMARK 465 THR A -9
REMARK 465 GLU A -8
REMARK 465 ASN A -7
REMARK 465 LEU A -6
REMARK 465 TYR A -5
REMARK 465 PHE A -4
REMARK 465 GLN A -3
REMARK 465 GLY A -2
REMARK 465 ALA A -1
REMARK 465 HIS A 0
REMARK 465 ASP A 156
REMARK 465 PRO A 157
REMARK 465 SER A 158
REMARK 465 ILE A 159
REMARK 465 LEU A 160
REMARK 465 LYS A 161
REMARK 465 GLY A 162
REMARK 465 GLU A 163
REMARK 465 PRO A 164
REMARK 465 ALA A 165
REMARK 465 SER A 166
REMARK 465 GLY A 167
REMARK 465 LYS A 168
REMARK 465 LYS A 202
REMARK 465 GLU A 203
REMARK 465 ASN A 204
REMARK 465 ARG A 205
REMARK 465 GLN A 206
REMARK 465 SER A 207
REMARK 465 ILE A 208
REMARK 465 ILE A 209
REMARK 465 ASN A 210
REMARK 465 SER A 460
REMARK 465 THR A 461
REMARK 465 LYS A 462
REMARK 465 VAL A 463
REMARK 465 GLU A 464
REMARK 465 VAL A 465
REMARK 465 ASP A 466
REMARK 465 MET A 467
REMARK 465 GLU A 468
REMARK 465 LYS A 469
REMARK 465 ALA A 470
REMARK 465 GLU A 471
REMARK 465 SER A 472
REMARK 465 LEU A 473
REMARK 465 GLN A 474
REMARK 465 VAL A 475
REMARK 465 THR A 476
REMARK 465 SER A 739
REMARK 465 PRO A 740
REMARK 465 LEU A 741
REMARK 465 ASP A 742
REMARK 465 PHE A 743
REMARK 465 ASP A 744
REMARK 465 MET B -23
REMARK 465 GLY B -22
REMARK 465 HIS B -21
REMARK 465 HIS B -20
REMARK 465 HIS B -19
REMARK 465 HIS B -18
REMARK 465 HIS B -17
REMARK 465 HIS B -16
REMARK 465 ASP B -15
REMARK 465 TYR B -14
REMARK 465 ASP B -13
REMARK 465 ILE B -12
REMARK 465 PRO B -11
REMARK 465 THR B -10
REMARK 465 THR B -9
REMARK 465 GLU B -8
REMARK 465 ASN B -7
REMARK 465 LEU B -6
REMARK 465 TYR B -5
REMARK 465 PHE B -4
REMARK 465 GLN B -3
REMARK 465 GLY B -2
REMARK 465 ALA B -1
REMARK 465 HIS B 0
REMARK 465 ASP B 156
REMARK 465 PRO B 157
REMARK 465 SER B 158
REMARK 465 ILE B 159
REMARK 465 LEU B 160
REMARK 465 LYS B 161
REMARK 465 GLY B 162
REMARK 465 GLU B 163
REMARK 465 PRO B 164
REMARK 465 ALA B 165
REMARK 465 SER B 166
REMARK 465 GLY B 167
REMARK 465 LYS B 168
REMARK 465 LYS B 202
REMARK 465 GLU B 203
REMARK 465 ASN B 204
REMARK 465 ARG B 205
REMARK 465 GLN B 206
REMARK 465 SER B 207
REMARK 465 ILE B 208
REMARK 465 THR B 461
REMARK 465 LYS B 462
REMARK 465 VAL B 463
REMARK 465 GLU B 464
REMARK 465 VAL B 465
REMARK 465 ASP B 466
REMARK 465 MET B 467
REMARK 465 GLU B 468
REMARK 465 LYS B 469
REMARK 465 ALA B 470
REMARK 465 GLU B 471
REMARK 465 SER B 472
REMARK 465 LEU B 473
REMARK 465 GLN B 474
REMARK 465 SER B 739
REMARK 465 PRO B 740
REMARK 465 LEU B 741
REMARK 465 ASP B 742
REMARK 465 PHE B 743
REMARK 465 ASP B 744
REMARK 465 MET C -23
REMARK 465 GLY C -22
REMARK 465 HIS C -21
REMARK 465 HIS C -20
REMARK 465 HIS C -19
REMARK 465 HIS C -18
REMARK 465 HIS C -17
REMARK 465 HIS C -16
REMARK 465 ASP C -15
REMARK 465 TYR C -14
REMARK 465 ASP C -13
REMARK 465 ILE C -12
REMARK 465 PRO C -11
REMARK 465 THR C -10
REMARK 465 THR C -9
REMARK 465 GLU C -8
REMARK 465 ASN C -7
REMARK 465 LEU C -6
REMARK 465 TYR C -5
REMARK 465 PHE C -4
REMARK 465 GLN C -3
REMARK 465 GLY C -2
REMARK 465 ALA C -1
REMARK 465 HIS C 0
REMARK 465 ASP C 156
REMARK 465 PRO C 157
REMARK 465 SER C 158
REMARK 465 ILE C 159
REMARK 465 LEU C 160
REMARK 465 LYS C 161
REMARK 465 GLY C 162
REMARK 465 GLU C 163
REMARK 465 PRO C 164
REMARK 465 ALA C 165
REMARK 465 SER C 166
REMARK 465 GLY C 167
REMARK 465 LYS C 168
REMARK 465 LYS C 202
REMARK 465 GLU C 203
REMARK 465 ASN C 204
REMARK 465 ARG C 205
REMARK 465 GLN C 206
REMARK 465 SER C 207
REMARK 465 ILE C 458
REMARK 465 ALA C 459
REMARK 465 SER C 460
REMARK 465 THR C 461
REMARK 465 LYS C 462
REMARK 465 VAL C 463
REMARK 465 GLU C 464
REMARK 465 VAL C 465
REMARK 465 ASP C 466
REMARK 465 MET C 467
REMARK 465 SER C 739
REMARK 465 PRO C 740
REMARK 465 LEU C 741
REMARK 465 ASP C 742
REMARK 465 PHE C 743
REMARK 465 ASP C 744
REMARK 465 MET D -23
REMARK 465 GLY D -22
REMARK 465 HIS D -21
REMARK 465 HIS D -20
REMARK 465 HIS D -19
REMARK 465 HIS D -18
REMARK 465 HIS D -17
REMARK 465 HIS D -16
REMARK 465 ASP D -15
REMARK 465 TYR D -14
REMARK 465 ASP D -13
REMARK 465 ILE D -12
REMARK 465 PRO D -11
REMARK 465 THR D -10
REMARK 465 THR D -9
REMARK 465 GLU D -8
REMARK 465 ASN D -7
REMARK 465 LEU D -6
REMARK 465 TYR D -5
REMARK 465 PHE D -4
REMARK 465 GLN D -3
REMARK 465 GLY D -2
REMARK 465 ALA D -1
REMARK 465 HIS D 0
REMARK 465 ASP D 156
REMARK 465 PRO D 157
REMARK 465 SER D 158
REMARK 465 ILE D 159
REMARK 465 LEU D 160
REMARK 465 LYS D 161
REMARK 465 GLY D 162
REMARK 465 GLU D 163
REMARK 465 PRO D 164
REMARK 465 ALA D 165
REMARK 465 SER D 166
REMARK 465 GLY D 167
REMARK 465 LYS D 168
REMARK 465 LYS D 202
REMARK 465 GLU D 203
REMARK 465 ASN D 204
REMARK 465 ARG D 205
REMARK 465 GLN D 206
REMARK 465 SER D 207
REMARK 465 ALA D 459
REMARK 465 SER D 460
REMARK 465 THR D 461
REMARK 465 LYS D 462
REMARK 465 VAL D 463
REMARK 465 GLU D 464
REMARK 465 SER D 739
REMARK 465 PRO D 740
REMARK 465 LEU D 741
REMARK 465 ASP D 742
REMARK 465 PHE D 743
REMARK 465 ASP D 744
REMARK 465 MET E -23
REMARK 465 GLY E -22
REMARK 465 HIS E -21
REMARK 465 HIS E -20
REMARK 465 HIS E -19
REMARK 465 HIS E -18
REMARK 465 HIS E -17
REMARK 465 HIS E -16
REMARK 465 ASP E -15
REMARK 465 TYR E -14
REMARK 465 ASP E -13
REMARK 465 ILE E -12
REMARK 465 PRO E -11
REMARK 465 THR E -10
REMARK 465 THR E -9
REMARK 465 GLU E -8
REMARK 465 ASN E -7
REMARK 465 LEU E -6
REMARK 465 TYR E -5
REMARK 465 PHE E -4
REMARK 465 GLN E -3
REMARK 465 GLY E -2
REMARK 465 ALA E -1
REMARK 465 HIS E 0
REMARK 465 MET E 1
REMARK 465 ALA E 2
REMARK 465 GLY E 3
REMARK 465 ARG E 4
REMARK 465 SER E 5
REMARK 465 MET E 6
REMARK 465 GLN E 7
REMARK 465 ALA E 8
REMARK 465 ALA E 9
REMARK 465 ARG E 10
REMARK 465 CYS E 11
REMARK 465 PRO E 12
REMARK 465 THR E 13
REMARK 465 ASP E 14
REMARK 465 GLU E 15
REMARK 465 LEU E 16
REMARK 465 SER E 17
REMARK 465 LEU E 18
REMARK 465 SER E 19
REMARK 465 ASN E 20
REMARK 465 CYS E 21
REMARK 465 ALA E 22
REMARK 465 VAL E 23
REMARK 465 VAL E 24
REMARK 465 SER E 25
REMARK 465 GLU E 26
REMARK 465 LYS E 27
REMARK 465 ASP E 28
REMARK 465 TYR E 29
REMARK 465 GLN E 30
REMARK 465 SER E 31
REMARK 465 GLY E 32
REMARK 465 GLN E 33
REMARK 465 HIS E 34
REMARK 465 VAL E 35
REMARK 465 ILE E 36
REMARK 465 VAL E 37
REMARK 465 ARG E 38
REMARK 465 THR E 39
REMARK 465 SER E 40
REMARK 465 PRO E 41
REMARK 465 ASN E 42
REMARK 465 HIS E 43
REMARK 465 LYS E 44
REMARK 465 TYR E 45
REMARK 465 ILE E 46
REMARK 465 PHE E 47
REMARK 465 THR E 48
REMARK 465 LEU E 49
REMARK 465 ARG E 50
REMARK 465 THR E 51
REMARK 465 HIS E 52
REMARK 465 PRO E 53
REMARK 465 SER E 54
REMARK 465 VAL E 55
REMARK 465 VAL E 56
REMARK 465 PRO E 57
REMARK 465 GLY E 58
REMARK 465 SER E 59
REMARK 465 VAL E 60
REMARK 465 ALA E 61
REMARK 465 PHE E 62
REMARK 465 SER E 63
REMARK 465 LEU E 64
REMARK 465 PRO E 65
REMARK 465 GLN E 66
REMARK 465 ARG E 67
REMARK 465 LYS E 68
REMARK 465 TRP E 69
REMARK 465 ALA E 70
REMARK 465 GLY E 71
REMARK 465 LEU E 72
REMARK 465 SER E 73
REMARK 465 ILE E 74
REMARK 465 GLY E 75
REMARK 465 GLN E 76
REMARK 465 GLU E 77
REMARK 465 ILE E 78
REMARK 465 GLU E 79
REMARK 465 VAL E 80
REMARK 465 ALA E 81
REMARK 465 LEU E 82
REMARK 465 TYR E 83
REMARK 465 SER E 84
REMARK 465 PHE E 85
REMARK 465 ASP E 86
REMARK 465 LYS E 87
REMARK 465 ALA E 88
REMARK 465 LYS E 89
REMARK 465 GLN E 90
REMARK 465 CYS E 91
REMARK 465 ILE E 92
REMARK 465 GLY E 93
REMARK 465 THR E 94
REMARK 465 MET E 95
REMARK 465 THR E 96
REMARK 465 ILE E 97
REMARK 465 GLU E 98
REMARK 465 ILE E 99
REMARK 465 ASP E 100
REMARK 465 PHE E 101
REMARK 465 LEU E 102
REMARK 465 GLN E 103
REMARK 465 LYS E 104
REMARK 465 LYS E 105
REMARK 465 ASN E 106
REMARK 465 ILE E 107
REMARK 465 ASP E 108
REMARK 465 SER E 109
REMARK 465 ASN E 110
REMARK 465 PRO E 111
REMARK 465 TYR E 112
REMARK 465 ASP E 113
REMARK 465 THR E 114
REMARK 465 ASP E 115
REMARK 465 LYS E 116
REMARK 465 MET E 117
REMARK 465 ALA E 118
REMARK 465 ALA E 119
REMARK 465 GLU E 120
REMARK 465 PHE E 121
REMARK 465 ILE E 122
REMARK 465 GLN E 123
REMARK 465 GLN E 124
REMARK 465 PHE E 125
REMARK 465 ASN E 126
REMARK 465 ASN E 127
REMARK 465 GLN E 128
REMARK 465 ALA E 129
REMARK 465 PHE E 130
REMARK 465 SER E 131
REMARK 465 VAL E 132
REMARK 465 GLY E 133
REMARK 465 GLN E 134
REMARK 465 GLN E 135
REMARK 465 LEU E 136
REMARK 465 VAL E 137
REMARK 465 PHE E 138
REMARK 465 SER E 139
REMARK 465 PHE E 140
REMARK 465 ASN E 141
REMARK 465 ASP E 142
REMARK 465 LYS E 143
REMARK 465 LEU E 144
REMARK 465 PHE E 145
REMARK 465 GLY E 146
REMARK 465 LEU E 147
REMARK 465 LEU E 148
REMARK 465 VAL E 149
REMARK 465 LYS E 150
REMARK 465 ASP E 151
REMARK 465 ILE E 152
REMARK 465 GLU E 153
REMARK 465 ALA E 154
REMARK 465 MET E 155
REMARK 465 ASP E 156
REMARK 465 PRO E 157
REMARK 465 SER E 158
REMARK 465 ILE E 159
REMARK 465 LEU E 160
REMARK 465 LYS E 161
REMARK 465 GLY E 162
REMARK 465 GLU E 163
REMARK 465 PRO E 164
REMARK 465 ALA E 165
REMARK 465 SER E 166
REMARK 465 GLY E 167
REMARK 465 LYS E 168
REMARK 465 ARG E 169
REMARK 465 GLN E 170
REMARK 465 LYS E 171
REMARK 465 ILE E 172
REMARK 465 GLU E 173
REMARK 465 VAL E 174
REMARK 465 GLY E 175
REMARK 465 LEU E 176
REMARK 465 VAL E 177
REMARK 465 VAL E 178
REMARK 465 GLY E 179
REMARK 465 ASN E 180
REMARK 465 SER E 181
REMARK 465 GLN E 182
REMARK 465 VAL E 183
REMARK 465 ALA E 184
REMARK 465 PHE E 185
REMARK 465 GLU E 186
REMARK 465 LYS E 187
REMARK 465 ALA E 188
REMARK 465 GLU E 189
REMARK 465 ASN E 190
REMARK 465 SER E 191
REMARK 465 SER E 192
REMARK 465 LEU E 193
REMARK 465 ASN E 194
REMARK 465 LEU E 195
REMARK 465 ILE E 196
REMARK 465 GLY E 197
REMARK 465 LYS E 198
REMARK 465 ALA E 199
REMARK 465 LYS E 200
REMARK 465 THR E 201
REMARK 465 LYS E 202
REMARK 465 GLU E 203
REMARK 465 ASN E 204
REMARK 465 ARG E 205
REMARK 465 GLN E 206
REMARK 465 SER E 207
REMARK 465 ILE E 208
REMARK 465 ILE E 209
REMARK 465 PRO E 241
REMARK 465 PRO E 242
REMARK 465 GLU E 243
REMARK 465 ILE E 244
REMARK 465 VAL E 245
REMARK 465 GLU E 246
REMARK 465 GLN E 247
REMARK 465 MET E 248
REMARK 465 GLY E 249
REMARK 465 ALA E 459
REMARK 465 SER E 460
REMARK 465 THR E 461
REMARK 465 LYS E 462
REMARK 465 VAL E 463
REMARK 465 GLU E 464
REMARK 465 SER E 739
REMARK 465 PRO E 740
REMARK 465 LEU E 741
REMARK 465 ASP E 742
REMARK 465 PHE E 743
REMARK 465 ASP E 744
REMARK 465 MET F -23
REMARK 465 GLY F -22
REMARK 465 HIS F -21
REMARK 465 HIS F -20
REMARK 465 HIS F -19
REMARK 465 HIS F -18
REMARK 465 HIS F -17
REMARK 465 HIS F -16
REMARK 465 ASP F -15
REMARK 465 TYR F -14
REMARK 465 ASP F -13
REMARK 465 ILE F -12
REMARK 465 PRO F -11
REMARK 465 THR F -10
REMARK 465 THR F -9
REMARK 465 GLU F -8
REMARK 465 ASN F -7
REMARK 465 LEU F -6
REMARK 465 TYR F -5
REMARK 465 PHE F -4
REMARK 465 GLN F -3
REMARK 465 GLY F -2
REMARK 465 ALA F -1
REMARK 465 HIS F 0
REMARK 465 MET F 1
REMARK 465 ALA F 2
REMARK 465 GLY F 3
REMARK 465 ARG F 4
REMARK 465 SER F 5
REMARK 465 MET F 6
REMARK 465 GLN F 7
REMARK 465 ALA F 8
REMARK 465 ALA F 9
REMARK 465 ARG F 10
REMARK 465 CYS F 11
REMARK 465 PRO F 12
REMARK 465 THR F 13
REMARK 465 ASP F 14
REMARK 465 GLU F 15
REMARK 465 LEU F 16
REMARK 465 SER F 17
REMARK 465 LEU F 18
REMARK 465 SER F 19
REMARK 465 ASN F 20
REMARK 465 CYS F 21
REMARK 465 ALA F 22
REMARK 465 VAL F 23
REMARK 465 VAL F 24
REMARK 465 SER F 25
REMARK 465 GLU F 26
REMARK 465 LYS F 27
REMARK 465 ASP F 28
REMARK 465 TYR F 29
REMARK 465 GLN F 30
REMARK 465 SER F 31
REMARK 465 GLY F 32
REMARK 465 GLN F 33
REMARK 465 HIS F 34
REMARK 465 VAL F 35
REMARK 465 ILE F 36
REMARK 465 VAL F 37
REMARK 465 ARG F 38
REMARK 465 THR F 39
REMARK 465 SER F 40
REMARK 465 PRO F 41
REMARK 465 ASN F 42
REMARK 465 HIS F 43
REMARK 465 LYS F 44
REMARK 465 TYR F 45
REMARK 465 ILE F 46
REMARK 465 PHE F 47
REMARK 465 THR F 48
REMARK 465 LEU F 49
REMARK 465 ARG F 50
REMARK 465 THR F 51
REMARK 465 HIS F 52
REMARK 465 PRO F 53
REMARK 465 SER F 54
REMARK 465 VAL F 55
REMARK 465 VAL F 56
REMARK 465 PRO F 57
REMARK 465 GLY F 58
REMARK 465 SER F 59
REMARK 465 VAL F 60
REMARK 465 ALA F 61
REMARK 465 PHE F 62
REMARK 465 SER F 63
REMARK 465 LEU F 64
REMARK 465 PRO F 65
REMARK 465 GLN F 66
REMARK 465 ARG F 67
REMARK 465 LYS F 68
REMARK 465 TRP F 69
REMARK 465 ALA F 70
REMARK 465 GLY F 71
REMARK 465 LEU F 72
REMARK 465 SER F 73
REMARK 465 ILE F 74
REMARK 465 GLY F 75
REMARK 465 GLN F 76
REMARK 465 GLU F 77
REMARK 465 ILE F 78
REMARK 465 GLU F 79
REMARK 465 VAL F 80
REMARK 465 ALA F 81
REMARK 465 LEU F 82
REMARK 465 TYR F 83
REMARK 465 SER F 84
REMARK 465 PHE F 85
REMARK 465 ASP F 86
REMARK 465 LYS F 87
REMARK 465 ALA F 88
REMARK 465 LYS F 89
REMARK 465 GLN F 90
REMARK 465 CYS F 91
REMARK 465 ILE F 92
REMARK 465 GLY F 93
REMARK 465 THR F 94
REMARK 465 MET F 95
REMARK 465 THR F 96
REMARK 465 ILE F 97
REMARK 465 GLU F 98
REMARK 465 ILE F 99
REMARK 465 ASP F 100
REMARK 465 PHE F 101
REMARK 465 LEU F 102
REMARK 465 GLN F 103
REMARK 465 LYS F 104
REMARK 465 LYS F 105
REMARK 465 ASN F 106
REMARK 465 ILE F 107
REMARK 465 ASP F 108
REMARK 465 SER F 109
REMARK 465 ASN F 110
REMARK 465 PRO F 111
REMARK 465 TYR F 112
REMARK 465 ASP F 113
REMARK 465 THR F 114
REMARK 465 ASP F 115
REMARK 465 LYS F 116
REMARK 465 MET F 117
REMARK 465 ALA F 118
REMARK 465 ALA F 119
REMARK 465 GLU F 120
REMARK 465 PHE F 121
REMARK 465 ILE F 122
REMARK 465 GLN F 123
REMARK 465 GLN F 124
REMARK 465 PHE F 125
REMARK 465 ASN F 126
REMARK 465 ASN F 127
REMARK 465 GLN F 128
REMARK 465 ALA F 129
REMARK 465 PHE F 130
REMARK 465 SER F 131
REMARK 465 VAL F 132
REMARK 465 GLY F 133
REMARK 465 GLN F 134
REMARK 465 GLN F 135
REMARK 465 LEU F 136
REMARK 465 VAL F 137
REMARK 465 PHE F 138
REMARK 465 SER F 139
REMARK 465 PHE F 140
REMARK 465 ASN F 141
REMARK 465 ASP F 142
REMARK 465 LYS F 143
REMARK 465 LEU F 144
REMARK 465 PHE F 145
REMARK 465 GLY F 146
REMARK 465 LEU F 147
REMARK 465 LEU F 148
REMARK 465 VAL F 149
REMARK 465 LYS F 150
REMARK 465 ASP F 151
REMARK 465 ILE F 152
REMARK 465 GLU F 153
REMARK 465 ALA F 154
REMARK 465 MET F 155
REMARK 465 ASP F 156
REMARK 465 PRO F 157
REMARK 465 SER F 158
REMARK 465 ILE F 159
REMARK 465 LEU F 160
REMARK 465 LYS F 161
REMARK 465 GLY F 162
REMARK 465 GLU F 163
REMARK 465 PRO F 164
REMARK 465 ALA F 165
REMARK 465 SER F 166
REMARK 465 GLY F 167
REMARK 465 LYS F 168
REMARK 465 ARG F 169
REMARK 465 GLN F 170
REMARK 465 LYS F 171
REMARK 465 ILE F 172
REMARK 465 GLU F 173
REMARK 465 VAL F 174
REMARK 465 GLY F 175
REMARK 465 LEU F 176
REMARK 465 VAL F 177
REMARK 465 VAL F 178
REMARK 465 GLY F 179
REMARK 465 ASN F 180
REMARK 465 SER F 181
REMARK 465 GLN F 182
REMARK 465 VAL F 183
REMARK 465 ALA F 184
REMARK 465 PHE F 185
REMARK 465 GLU F 186
REMARK 465 LYS F 187
REMARK 465 ALA F 188
REMARK 465 GLU F 189
REMARK 465 ASN F 190
REMARK 465 SER F 191
REMARK 465 SER F 192
REMARK 465 LEU F 193
REMARK 465 ASN F 194
REMARK 465 LEU F 195
REMARK 465 ILE F 196
REMARK 465 GLY F 197
REMARK 465 LYS F 198
REMARK 465 ALA F 199
REMARK 465 LYS F 200
REMARK 465 THR F 201
REMARK 465 LYS F 202
REMARK 465 GLU F 203
REMARK 465 ASN F 204
REMARK 465 ARG F 205
REMARK 465 GLN F 206
REMARK 465 SER F 207
REMARK 465 ILE F 208
REMARK 465 ILE F 209
REMARK 465 ASN F 210
REMARK 465 PRO F 211
REMARK 465 ASP F 212
REMARK 465 TRP F 213
REMARK 465 ASN F 214
REMARK 465 PHE F 215
REMARK 465 GLU F 216
REMARK 465 LYS F 217
REMARK 465 MET F 218
REMARK 465 PHE F 240
REMARK 465 PRO F 241
REMARK 465 PRO F 242
REMARK 465 GLU F 243
REMARK 465 ILE F 244
REMARK 465 VAL F 245
REMARK 465 GLU F 246
REMARK 465 GLN F 247
REMARK 465 MET F 248
REMARK 465 GLY F 249
REMARK 465 CYS F 250
REMARK 465 ASP F 331
REMARK 465 ALA F 332
REMARK 465 ILE F 333
REMARK 465 CYS F 334
REMARK 465 LYS F 335
REMARK 465 GLN F 336
REMARK 465 ARG F 337
REMARK 465 GLY F 338
REMARK 465 SER F 339
REMARK 465 MET F 340
REMARK 465 ALA F 341
REMARK 465 GLY F 342
REMARK 465 SER F 343
REMARK 465 THR F 344
REMARK 465 GLY F 345
REMARK 465 VAL F 346
REMARK 465 VAL F 391
REMARK 465 LYS F 392
REMARK 465 MET F 393
REMARK 465 GLU F 394
REMARK 465 ILE F 395
REMARK 465 GLY F 396
REMARK 465 LEU F 397
REMARK 465 ARG F 415
REMARK 465 GLY F 416
REMARK 465 HIS F 417
REMARK 465 GLN F 418
REMARK 465 LEU F 419
REMARK 465 LEU F 420
REMARK 465 SER F 421
REMARK 465 ILE F 458
REMARK 465 ALA F 459
REMARK 465 SER F 460
REMARK 465 THR F 461
REMARK 465 LYS F 462
REMARK 465 VAL F 463
REMARK 465 GLU F 464
REMARK 465 VAL F 465
REMARK 465 ASP F 466
REMARK 465 MET F 467
REMARK 465 GLU F 468
REMARK 465 LYS F 469
REMARK 465 ALA F 470
REMARK 465 SER F 739
REMARK 465 PRO F 740
REMARK 465 LEU F 741
REMARK 465 ASP F 742
REMARK 465 PHE F 743
REMARK 465 ASP F 744
REMARK 465 MET H -2
REMARK 465 ALA H -1
REMARK 465 SER H 0
REMARK 465 CYS H 84
REMARK 465 CYS H 85
REMARK 465 GLY H 86
REMARK 465 LEU H 87
REMARK 465 PHE H 88
REMARK 465 ILE H 89
REMARK 465 CYS H 90
REMARK 465 PRO H 91
REMARK 465 CYS H 92
REMARK 465 ASN H 93
REMARK 465 LYS H 94
REMARK 465 LEU H 95
REMARK 465 LYS H 96
REMARK 465 SER H 97
REMARK 465 SER H 98
REMARK 465 ASP H 99
REMARK 465 ALA H 100
REMARK 465 TYR H 101
REMARK 465 LYS H 102
REMARK 465 LYS H 103
REMARK 465 ALA H 104
REMARK 465 TRP H 105
REMARK 465 GLY H 106
REMARK 465 ASN H 107
REMARK 465 ASN H 108
REMARK 465 GLN H 109
REMARK 465 ASP H 110
REMARK 465 GLY H 111
REMARK 465 VAL H 112
REMARK 465 VAL H 113
REMARK 465 ALA H 114
REMARK 465 SER H 115
REMARK 465 GLN H 116
REMARK 465 PRO H 117
REMARK 465 ALA H 118
REMARK 465 ARG H 119
REMARK 465 VAL H 120
REMARK 465 VAL H 121
REMARK 465 ASP H 122
REMARK 465 GLU H 123
REMARK 465 ARG H 124
REMARK 465 GLU H 125
REMARK 465 GLN H 126
REMARK 465 MET H 127
REMARK 465 ALA H 128
REMARK 465 ILE H 129
REMARK 465 SER H 130
REMARK 465 GLY H 131
REMARK 465 GLY H 132
REMARK 465 PHE H 133
REMARK 465 ILE H 134
REMARK 465 ARG H 135
REMARK 465 ARG H 136
REMARK 465 VAL H 137
REMARK 465 THR H 138
REMARK 465 ASN H 139
REMARK 465 ASP H 140
REMARK 465 MET I 1
REMARK 465 LYS I 2
REMARK 465 ASP I 3
REMARK 465 ARG I 4
REMARK 465 THR I 5
REMARK 465 GLN I 6
REMARK 465 GLU I 7
REMARK 465 LEU I 8
REMARK 465 ARG I 9
REMARK 465 THR I 10
REMARK 465 ALA I 11
REMARK 465 LYS I 12
REMARK 465 ASP I 13
REMARK 465 SER I 14
REMARK 465 ASP I 15
REMARK 465 ASP I 16
REMARK 465 ASP I 17
REMARK 465 ASP I 18
REMARK 465 ASP I 19
REMARK 465 VAL I 20
REMARK 465 THR I 21
REMARK 465 VAL I 22
REMARK 465 THR I 23
REMARK 465 VAL I 24
REMARK 465 ASP I 25
REMARK 465 ARG I 26
REMARK 465 ASP I 27
REMARK 465 ARG I 28
REMARK 465 PHE I 29
REMARK 465 MET I 30
REMARK 465 ASP I 31
REMARK 465 GLU I 32
REMARK 465 PHE I 33
REMARK 465 PHE I 34
REMARK 465 GLU I 35
REMARK 465 GLN I 36
REMARK 465 VAL I 37
REMARK 465 GLU I 38
REMARK 465 GLU I 39
REMARK 465 ILE I 40
REMARK 465 ARG I 41
REMARK 465 GLY I 42
REMARK 465 PHE I 43
REMARK 465 ILE I 44
REMARK 465 ASP I 45
REMARK 465 LYS I 46
REMARK 465 ILE I 47
REMARK 465 ALA I 48
REMARK 465 GLU I 49
REMARK 465 ASN I 50
REMARK 465 VAL I 51
REMARK 465 GLU I 52
REMARK 465 GLU I 53
REMARK 465 VAL I 54
REMARK 465 LYS I 55
REMARK 465 ARG I 56
REMARK 465 LYS I 57
REMARK 465 HIS I 58
REMARK 465 SER I 59
REMARK 465 ALA I 60
REMARK 465 ILE I 61
REMARK 465 LEU I 62
REMARK 465 ALA I 63
REMARK 465 SER I 64
REMARK 465 PRO I 65
REMARK 465 ASN I 66
REMARK 465 PRO I 67
REMARK 465 ASP I 68
REMARK 465 GLU I 69
REMARK 465 LYS I 70
REMARK 465 THR I 71
REMARK 465 LYS I 72
REMARK 465 GLU I 73
REMARK 465 GLU I 74
REMARK 465 LEU I 75
REMARK 465 GLU I 76
REMARK 465 GLU I 77
REMARK 465 LEU I 78
REMARK 465 MET I 79
REMARK 465 SER I 80
REMARK 465 ASP I 81
REMARK 465 ILE I 82
REMARK 465 LYS I 83
REMARK 465 LYS I 84
REMARK 465 THR I 85
REMARK 465 ALA I 86
REMARK 465 ASN I 87
REMARK 465 LYS I 88
REMARK 465 VAL I 89
REMARK 465 ARG I 90
REMARK 465 SER I 91
REMARK 465 LYS I 92
REMARK 465 LEU I 93
REMARK 465 LYS I 94
REMARK 465 SER I 95
REMARK 465 ILE I 96
REMARK 465 GLU I 97
REMARK 465 GLN I 98
REMARK 465 SER I 99
REMARK 465 ILE I 100
REMARK 465 GLU I 101
REMARK 465 GLN I 102
REMARK 465 GLU I 103
REMARK 465 GLU I 104
REMARK 465 GLY I 105
REMARK 465 LEU I 106
REMARK 465 ASN I 107
REMARK 465 ARG I 108
REMARK 465 SER I 109
REMARK 465 SER I 110
REMARK 465 ALA I 111
REMARK 465 ASP I 112
REMARK 465 LEU I 113
REMARK 465 ARG I 114
REMARK 465 ILE I 115
REMARK 465 ARG I 116
REMARK 465 LYS I 117
REMARK 465 THR I 118
REMARK 465 GLN I 119
REMARK 465 HIS I 120
REMARK 465 SER I 121
REMARK 465 THR I 122
REMARK 465 LEU I 123
REMARK 465 SER I 124
REMARK 465 ARG I 125
REMARK 465 LYS I 126
REMARK 465 PHE I 127
REMARK 465 VAL I 128
REMARK 465 GLU I 129
REMARK 465 VAL I 130
REMARK 465 MET I 131
REMARK 465 SER I 132
REMARK 465 GLU I 133
REMARK 465 TYR I 134
REMARK 465 ASN I 135
REMARK 465 ALA I 136
REMARK 465 THR I 137
REMARK 465 GLN I 138
REMARK 465 SER I 139
REMARK 465 ASP I 140
REMARK 465 TYR I 141
REMARK 465 ARG I 142
REMARK 465 GLU I 143
REMARK 465 ARG I 144
REMARK 465 SER I 145
REMARK 465 LYS I 146
REMARK 465 GLY I 147
REMARK 465 ARG I 148
REMARK 465 ILE I 149
REMARK 465 GLN I 150
REMARK 465 ARG I 151
REMARK 465 GLN I 152
REMARK 465 LEU I 153
REMARK 465 GLU I 154
REMARK 465 ILE I 155
REMARK 465 THR I 156
REMARK 465 GLY I 157
REMARK 465 ARG I 158
REMARK 465 THR I 159
REMARK 465 THR I 160
REMARK 465 THR I 161
REMARK 465 SER I 162
REMARK 465 GLU I 163
REMARK 465 GLU I 164
REMARK 465 LEU I 165
REMARK 465 GLU I 166
REMARK 465 ASP I 167
REMARK 465 MET I 168
REMARK 465 LEU I 169
REMARK 465 GLU I 170
REMARK 465 SER I 171
REMARK 465 GLY I 172
REMARK 465 ASN I 173
REMARK 465 PRO I 174
REMARK 465 ALA I 175
REMARK 465 ILE I 176
REMARK 465 PHE I 177
REMARK 465 ALA I 178
REMARK 465 SER I 179
REMARK 465 GLY I 180
REMARK 465 ILE I 181
REMARK 465 ILE I 182
REMARK 465 MET I 183
REMARK 465 ASP I 184
REMARK 465 SER I 185
REMARK 465 SER I 186
REMARK 465 ILE I 187
REMARK 465 SER I 188
REMARK 465 LYS I 189
REMARK 465 GLN I 190
REMARK 465 MET J -27
REMARK 465 ALA J -26
REMARK 465 SER J -25
REMARK 465 TYR J -24
REMARK 465 TYR J -23
REMARK 465 HIS J -22
REMARK 465 HIS J -21
REMARK 465 HIS J -20
REMARK 465 HIS J -19
REMARK 465 HIS J -18
REMARK 465 HIS J -17
REMARK 465 ASP J -16
REMARK 465 TYR J -15
REMARK 465 ASP J -14
REMARK 465 ILE J -13
REMARK 465 PRO J -12
REMARK 465 THR J -11
REMARK 465 SER J -10
REMARK 465 GLU J -9
REMARK 465 ASN J -8
REMARK 465 LEU J -7
REMARK 465 TYR J -6
REMARK 465 PHE J -5
REMARK 465 GLN J -4
REMARK 465 GLY J -3
REMARK 465 ALA J -2
REMARK 465 SER J -1
REMARK 465 HIS J 0
REMARK 465 MET J 1
REMARK 465 SER J 2
REMARK 465 ALA J 3
REMARK 465 THR J 4
REMARK 465 ALA J 5
REMARK 465 ALA J 6
REMARK 465 THR J 7
REMARK 465 VAL J 8
REMARK 465 PRO J 9
REMARK 465 PRO J 10
REMARK 465 ALA J 11
REMARK 465 ALA J 12
REMARK 465 PRO J 13
REMARK 465 ALA J 14
REMARK 465 GLY J 15
REMARK 465 GLU J 16
REMARK 465 GLY J 17
REMARK 465 GLY J 18
REMARK 465 PRO J 19
REMARK 465 PRO J 20
REMARK 465 ALA J 21
REMARK 465 PRO J 22
REMARK 465 PRO J 23
REMARK 465 PRO J 24
REMARK 465 ASN J 25
REMARK 465 LEU J 26
REMARK 465 THR J 27
REMARK 465 SER J 28
REMARK 465 MET K -17
REMARK 465 HIS K -16
REMARK 465 HIS K -15
REMARK 465 HIS K -14
REMARK 465 HIS K -13
REMARK 465 HIS K -12
REMARK 465 HIS K -11
REMARK 465 HIS K -10
REMARK 465 HIS K -9
REMARK 465 HIS K -8
REMARK 465 HIS K -7
REMARK 465 GLU K -6
REMARK 465 ASN K -5
REMARK 465 LEU K -4
REMARK 465 TYR K -3
REMARK 465 PHE K -2
REMARK 465 GLN K -1
REMARK 465 GLY K 0
REMARK 465 MET K 1
REMARK 465 ASP K 2
REMARK 465 THR K 3
REMARK 465 SER K 4
REMARK 465 GLY K 5
REMARK 465 LYS K 6
REMARK 465 GLN K 7
REMARK 465 LEU K 294
REMARK 465 ARG K 295
REMARK 465 MET L -17
REMARK 465 HIS L -16
REMARK 465 HIS L -15
REMARK 465 HIS L -14
REMARK 465 HIS L -13
REMARK 465 HIS L -12
REMARK 465 HIS L -11
REMARK 465 HIS L -10
REMARK 465 HIS L -9
REMARK 465 HIS L -8
REMARK 465 HIS L -7
REMARK 465 GLU L -6
REMARK 465 ASN L -5
REMARK 465 LEU L -4
REMARK 465 TYR L -3
REMARK 465 PHE L -2
REMARK 465 GLN L -1
REMARK 465 GLY L 0
REMARK 465 MET L 1
REMARK 465 ASP L 2
REMARK 465 THR L 3
REMARK 465 SER L 4
REMARK 465 GLY L 5
REMARK 465 LYS L 6
REMARK 465 GLN L 7
REMARK 465 LEU L 294
REMARK 465 ARG L 295
REMARK 470
REMARK 470 MISSING ATOM
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;
REMARK 470 I=INSERTION CODE):
REMARK 470 M RES CSSEQI ATOMS
REMARK 470 LEU F 223 CG CD1 CD2
REMARK 470 ARG F 238 CG CD NE CZ NH1 NH2
REMARK 470 LYS F 251 CG CD CE NZ
REMARK 470 HIS F 252 CG ND1 CD2 CE1 NE2
REMARK 470 LYS F 254 CG CD CE NZ
REMARK 470 LYS F 266 CG CD CE NZ
REMARK 470 LEU F 269 CG CD1 CD2
REMARK 470 LYS F 275 CG CD CE NZ
REMARK 470 MET F 276 CG SD CE
REMARK 470 LEU F 277 CG CD1 CD2
REMARK 470 ASN F 278 CG OD1 ND2
REMARK 470 ARG F 280 CG CD NE CZ NH1 NH2
REMARK 470 GLU F 281 CG CD OE1 OE2
REMARK 470 LYS F 283 CG CD CE NZ
REMARK 470 GLU F 289 CG CD OE1 OE2
REMARK 470 ILE F 290 CG1 CG2 CD1
REMARK 470 LEU F 291 CG CD1 CD2
REMARK 470 ASN F 292 CG OD1 ND2
REMARK 470 LYS F 293 CG CD CE NZ
REMARK 470 TYR F 294 CG CD1 CD2 CE1 CE2 CZ OH
REMARK 470 VAL F 295 CG1 CG2
REMARK 470 GLU F 297 CG CD OE1 OE2
REMARK 470 SER F 298 OG
REMARK 470 ILE F 302 CG1 CG2 CD1
REMARK 470 ILE F 325 CG1 CG2 CD1
REMARK 470 GLU F 329 CG CD OE1 OE2
REMARK 470 HIS F 347 CG ND1 CD2 CE1 NE2
REMARK 470 ASP F 348 CG OD1 OD2
REMARK 470 ASN F 352 CG OD1 ND2
REMARK 470 ASP F 359 CG OD1 OD2
REMARK 470 VAL F 361 CG1 CG2
REMARK 470 GLU F 362 CG CD OE1 OE2
REMARK 470 GLN F 363 CG CD OE1 NE2
REMARK 470 LEU F 364 CG CD1 CD2
REMARK 470 ASN F 366 CG OD1 ND2
REMARK 470 LEU F 383 CG CD1 CD2
REMARK 470 GLU F 390 CG CD OE1 OE2
REMARK 470 LYS H 83 CG CD CE NZ
REMARK 470 GLN J 71 CG CD OE1 NE2
REMARK 470 LYS K 222 CG CD CE NZ
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT
REMARK 500
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.
REMARK 500
REMARK 500 ATM1 RES C SSEQI ATM2 RES C SSEQI DISTANCE
REMARK 500 H ALA B 22 O THR B 48 1.57
REMARK 500 HH22 ARG E 607 O TYR E 611 1.58
REMARK 500 O ASP L 267 HH11 ARG L 271 1.58
REMARK 500 O TYR A 499 H ILE A 503 1.59
REMARK 500 OD1 ASP A 229 HH21 ARG A 233 1.59
REMARK 500 HZ2 LYS F 708 O3A ATP F 801 1.59
REMARK 500 O GLY L 34 H ILE L 38 1.59
REMARK 500 O SER A 538 OG SER A 662 1.94
REMARK 500 O SER D 538 OG SER D 662 1.95
REMARK 500 O ALA H 42 OG1 THR H 46 1.95
REMARK 500 O ASP C 512 OG1 THR C 515 1.99
REMARK 500 O SER F 538 OG SER F 662 2.01
REMARK 500 OG1 THR C 550 O1A ATP C 801 2.02
REMARK 500 O PHE C 564 OG SER C 598 2.03
REMARK 500 O TRP D 510 NE2 GLN D 675 2.04
REMARK 500 O SER B 538 OG SER B 662 2.06
REMARK 500 O SER C 538 OG SER C 662 2.06
REMARK 500 O ALA B 557 OG SER B 560 2.06
REMARK 500 O ASP A 688 OG1 THR A 692 2.06
REMARK 500 O ILE K 283 OG1 THR K 286 2.07
REMARK 500 OG SER D 356 OD2 ASP E 328 2.07
REMARK 500 NH1 ARG D 403 O THR D 433 2.07
REMARK 500 O GLU L 129 OG1 THR L 133 2.08
REMARK 500 O PRO C 544 OG SER C 547 2.08
REMARK 500 O LEU D 718 NH1 ARG D 725 2.09
REMARK 500 ND2 ASN C 669 O TRP C 704 2.09
REMARK 500 OG SER D 717 O ARG D 725 2.09
REMARK 500 O ALA E 430 OG1 THR E 433 2.10
REMARK 500 O MET B 453 ND1 HIS B 456 2.12
REMARK 500 O ILE B 92 OG SER B 181 2.12
REMARK 500 O ASN C 106 NZ LYS C 143 2.12
REMARK 500 O LYS F 689 OG1 THR F 692 2.12
REMARK 500 OE1 GLU C 442 O2' ATP C 802 2.13
REMARK 500 O LYS B 687 NH2 ARG B 691 2.14
REMARK 500 OE1 GLU B 542 ND1 HIS B 666 2.14
REMARK 500 OE1 GLU B 681 NH2 ARG B 691 2.15
REMARK 500 NZ LYS D 509 O GLY D 511 2.15
REMARK 500 O LYS A 251 NH1 ARG B 446 2.15
REMARK 500 OE1 GLN A 103 ND2 ASN A 106 2.15
REMARK 500 OG1 THR B 267 O1A ATP B 801 2.15
REMARK 500 NH1 ARG E 403 O THR E 433 2.15
REMARK 500 O ASP L 267 NH1 ARG L 271 2.16
REMARK 500 N SER D 320 OD1 ASN D 366 2.17
REMARK 500 OE1 GLN H 56 NH2 ARG H 59 2.18
REMARK 500 O GLU E 690 OG1 THR E 693 2.18
REMARK 500 OG1 THR A 267 O2A ADP A 802 2.18
REMARK 500 O ILE B 196 NZ LYS B 200 2.19
REMARK 500 NE2 HIS C 410 OE2 GLU C 442 2.19
REMARK 500 NH2 ARG E 607 O TYR E 611 2.19
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES
REMARK 500
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)
REMARK 500
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996
REMARK 500
REMARK 500 M RES CSSEQI ATM1 ATM2 ATM3
REMARK 500 LEU A 481 CB - CG - CD1 ANGL. DEV. = 10.2 DEGREES
REMARK 500 ASP A 610 CB - CG - OD1 ANGL. DEV. = 6.0 DEGREES
REMARK 500 GLY A 615 N - CA - C ANGL. DEV. = -15.6 DEGREES
REMARK 500 LYS B 200 CD - CE - NZ ANGL. DEV. = -16.6 DEGREES
REMARK 500 VAL B 346 CA - CB - CG2 ANGL. DEV. = 10.4 DEGREES
REMARK 500 ARG B 403 NE - CZ - NH1 ANGL. DEV. = 3.1 DEGREES
REMARK 500 LEU B 420 CB - CG - CD2 ANGL. DEV. = 16.3 DEGREES
REMARK 500 LEU C 444 CA - CB - CG ANGL. DEV. = 14.0 DEGREES
REMARK 500 LEU C 484 CB - CG - CD2 ANGL. DEV. = 15.3 DEGREES
REMARK 500 PHE D 306 CB - CG - CD1 ANGL. DEV. = 4.2 DEGREES
REMARK 500 GLY D 615 N - CA - C ANGL. DEV. = -15.8 DEGREES
REMARK 500 LEU D 730 CA - CB - CG ANGL. DEV. = 16.7 DEGREES
REMARK 500 ASP E 610 CB - CG - OD1 ANGL. DEV. = 7.0 DEGREES
REMARK 500 GLY E 615 N - CA - C ANGL. DEV. = -18.4 DEGREES
REMARK 500 ASP F 591 CB - CG - OD1 ANGL. DEV. = 5.9 DEGREES
REMARK 500 GLY F 615 N - CA - C ANGL. DEV. = -15.6 DEGREES
REMARK 500 VAL F 698 CG1 - CB - CG2 ANGL. DEV. = 11.4 DEGREES
REMARK 500 GLN K 67 CA - CB - CG ANGL. DEV. = 13.5 DEGREES
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500 M RES CSSEQI PSI PHI
REMARK 500 TYR A 29 -168.39 -113.12
REMARK 500 PRO A 53 23.83 -64.91
REMARK 500 ALA A 88 -69.06 -137.30
REMARK 500 ASN A 106 11.63 -146.43
REMARK 500 ASN A 180 51.10 -93.53
REMARK 500 PRO B 12 -76.04 -53.83
REMARK 500 PRO B 41 -4.52 -56.64
REMARK 500 ASP B 100 140.98 -172.17
REMARK 500 PHE B 125 47.35 -102.30
REMARK 500 ASN B 190 39.54 37.53
REMARK 500 ASP B 423 43.84 31.94
REMARK 500 ASP B 688 -69.21 -141.69
REMARK 500 ALA C 9 -164.51 -118.44
REMARK 500 ALA C 22 94.26 -65.17
REMARK 500 PRO C 53 12.04 -61.93
REMARK 500 ILE C 74 98.98 -69.15
REMARK 500 ASN C 106 30.76 -143.09
REMARK 500 ASN C 180 41.61 -98.00
REMARK 500 PHE C 215 75.36 -152.95
REMARK 500 THR C 534 62.96 -151.88
REMARK 500 ASP C 688 32.95 26.51
REMARK 500 THR D 13 -166.48 -119.18
REMARK 500 ASN D 42 12.67 -141.56
REMARK 500 PRO D 53 3.47 -58.38
REMARK 500 SER D 59 138.38 -170.50
REMARK 500 LYS D 87 44.82 -70.73
REMARK 500 LYS D 89 2.71 -150.41
REMARK 500 VAL D 178 -169.33 -125.90
REMARK 500 SER D 191 -152.94 -81.15
REMARK 500 ALA D 199 47.17 -80.56
REMARK 500 ARG D 280 165.55 175.59
REMARK 500 ARG D 315 -73.16 -56.88
REMARK 500 GLU E 289 -16.82 -48.26
REMARK 500 TYR F 294 -1.51 82.35
REMARK 500 SER F 298 7.80 87.55
REMARK 500 ASN F 366 11.71 87.68
REMARK 500 THR F 451 -74.33 -40.47
REMARK 500 THR F 534 64.74 -150.63
REMARK 500 GLN F 636 -61.01 -103.48
REMARK 500 ARG H 16 19.11 81.57
REMARK 500 LEU H 21 -29.90 -36.61
REMARK 500 ARG H 142 -25.63 -151.56
REMARK 500 TYR J 88 40.25 -102.16
REMARK 500 SER K 26 -165.73 -172.87
REMARK 500 LEU K 31 -60.12 -95.26
REMARK 500 LEU K 75 -80.27 -78.14
REMARK 500 GLN K 76 97.77 -166.67
REMARK 500 GLN K 98 -158.14 -79.17
REMARK 500 GLU K 99 -12.38 81.03
REMARK 500 PHE K 117 -39.45 -130.33
REMARK 500
REMARK 500 THIS ENTRY HAS 65 RAMACHANDRAN OUTLIERS.
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS
REMARK 500
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH
REMARK 500 CIS AND TRANS CONFORMATION. CIS BONDS, IF ANY, ARE LISTED
REMARK 500 ON CISPEP RECORDS. TRANS IS DEFINED AS 180 +/- 30 AND
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.
REMARK 500 MODEL OMEGA
REMARK 500 MET H 32 LEU H 33 148.92
REMARK 500 LEU K 75 GLN K 76 142.83
REMARK 500 HIS K 213 PHE K 214 -149.38
REMARK 500 PHE K 214 CYS K 215 -148.95
REMARK 500 LEU L 135 VAL L 136 -149.56
REMARK 500 PHE L 206 PHE L 207 143.18
REMARK 500
REMARK 500 REMARK: NULL
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: PLANAR GROUPS
REMARK 500
REMARK 500 PLANAR GROUPS IN THE FOLLOWING RESIDUES HAVE A TOTAL
REMARK 500 RMS DISTANCE OF ALL ATOMS FROM THE BEST-FIT PLANE
REMARK 500 BY MORE THAN AN EXPECTED VALUE OF 6*RMSD, WITH AN
REMARK 500 RMSD 0.02 ANGSTROMS, OR AT LEAST ONE ATOM HAS
REMARK 500 AN RMSD GREATER THAN THIS VALUE
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 M RES CSSEQI RMS TYPE
REMARK 500 GLN B 405 0.08 SIDE CHAIN
REMARK 500
REMARK 500 REMARK: NULL
REMARK 800
REMARK 800 SITE
REMARK 800 SITE_IDENTIFIER: AC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue ATP A 801
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue ADP A 802
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC3
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue ATP B 801
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC4
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue ATP B 802
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC5
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue ATP C 801
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC6
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue ATP C 802
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC7
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue ATP D 801
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC8
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue ATP D 802
REMARK 800
REMARK 800 SITE_IDENTIFIER: AC9
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue ATP E 801
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue ADP E 802
REMARK 800
REMARK 800 SITE_IDENTIFIER: AD2
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue ATP F 801
REMARK 900
REMARK 900 RELATED ENTRIES
REMARK 900 RELATED ID: EMD-9100 RELATED DB: EMDB
REMARK 900 THE 20S SUPERCOMPLEX ENGAGING THE SNAP-25 N-TERMINUS (CLASS 1)
DBREF 6MDM A 1 744 UNP P18708 NSF_CRIGR 1 744
DBREF 6MDM B 1 744 UNP P18708 NSF_CRIGR 1 744
DBREF 6MDM C 1 744 UNP P18708 NSF_CRIGR 1 744
DBREF 6MDM D 1 744 UNP P18708 NSF_CRIGR 1 744
DBREF 6MDM E 1 744 UNP P18708 NSF_CRIGR 1 744
DBREF 6MDM F 1 744 UNP P18708 NSF_CRIGR 1 744
DBREF 6MDM H 1 204 UNP P60881 SNP25_RAT 1 204
DBREF 6MDM I 1 256 UNP P32851 STX1A_RAT 1 256
DBREF 6MDM J 1 89 UNP P63045 VAMP2_RAT 1 89
DBREF 6MDM K 1 295 UNP P54921 SNAA_RAT 1 295
DBREF 6MDM L 1 295 UNP P54921 SNAA_RAT 1 295
SEQADV 6MDM MET A -23 UNP P18708 INITIATING METHIONINE
SEQADV 6MDM GLY A -22 UNP P18708 EXPRESSION TAG
SEQADV 6MDM HIS A -21 UNP P18708 EXPRESSION TAG
SEQADV 6MDM HIS A -20 UNP P18708 EXPRESSION TAG
SEQADV 6MDM HIS A -19 UNP P18708 EXPRESSION TAG
SEQADV 6MDM HIS A -18 UNP P18708 EXPRESSION TAG
SEQADV 6MDM HIS A -17 UNP P18708 EXPRESSION TAG
SEQADV 6MDM HIS A -16 UNP P18708 EXPRESSION TAG
SEQADV 6MDM ASP A -15 UNP P18708 EXPRESSION TAG
SEQADV 6MDM TYR A -14 UNP P18708 EXPRESSION TAG
SEQADV 6MDM ASP A -13 UNP P18708 EXPRESSION TAG
SEQADV 6MDM ILE A -12 UNP P18708 EXPRESSION TAG
SEQADV 6MDM PRO A -11 UNP P18708 EXPRESSION TAG
SEQADV 6MDM THR A -10 UNP P18708 EXPRESSION TAG
SEQADV 6MDM THR A -9 UNP P18708 EXPRESSION TAG
SEQADV 6MDM GLU A -8 UNP P18708 EXPRESSION TAG
SEQADV 6MDM ASN A -7 UNP P18708 EXPRESSION TAG
SEQADV 6MDM LEU A -6 UNP P18708 EXPRESSION TAG
SEQADV 6MDM TYR A -5 UNP P18708 EXPRESSION TAG
SEQADV 6MDM PHE A -4 UNP P18708 EXPRESSION TAG
SEQADV 6MDM GLN A -3 UNP P18708 EXPRESSION TAG
SEQADV 6MDM GLY A -2 UNP P18708 EXPRESSION TAG
SEQADV 6MDM ALA A -1 UNP P18708 EXPRESSION TAG
SEQADV 6MDM HIS A 0 UNP P18708 EXPRESSION TAG
SEQADV 6MDM ILE A 458 UNP P18708 LYS 458 CONFLICT
SEQADV 6MDM MET B -23 UNP P18708 INITIATING METHIONINE
SEQADV 6MDM GLY B -22 UNP P18708 EXPRESSION TAG
SEQADV 6MDM HIS B -21 UNP P18708 EXPRESSION TAG
SEQADV 6MDM HIS B -20 UNP P18708 EXPRESSION TAG
SEQADV 6MDM HIS B -19 UNP P18708 EXPRESSION TAG
SEQADV 6MDM HIS B -18 UNP P18708 EXPRESSION TAG
SEQADV 6MDM HIS B -17 UNP P18708 EXPRESSION TAG
SEQADV 6MDM HIS B -16 UNP P18708 EXPRESSION TAG
SEQADV 6MDM ASP B -15 UNP P18708 EXPRESSION TAG
SEQADV 6MDM TYR B -14 UNP P18708 EXPRESSION TAG
SEQADV 6MDM ASP B -13 UNP P18708 EXPRESSION TAG
SEQADV 6MDM ILE B -12 UNP P18708 EXPRESSION TAG
SEQADV 6MDM PRO B -11 UNP P18708 EXPRESSION TAG
SEQADV 6MDM THR B -10 UNP P18708 EXPRESSION TAG
SEQADV 6MDM THR B -9 UNP P18708 EXPRESSION TAG
SEQADV 6MDM GLU B -8 UNP P18708 EXPRESSION TAG
SEQADV 6MDM ASN B -7 UNP P18708 EXPRESSION TAG
SEQADV 6MDM LEU B -6 UNP P18708 EXPRESSION TAG
SEQADV 6MDM TYR B -5 UNP P18708 EXPRESSION TAG
SEQADV 6MDM PHE B -4 UNP P18708 EXPRESSION TAG
SEQADV 6MDM GLN B -3 UNP P18708 EXPRESSION TAG
SEQADV 6MDM GLY B -2 UNP P18708 EXPRESSION TAG
SEQADV 6MDM ALA B -1 UNP P18708 EXPRESSION TAG
SEQADV 6MDM HIS B 0 UNP P18708 EXPRESSION TAG
SEQADV 6MDM ILE B 458 UNP P18708 LYS 458 CONFLICT
SEQADV 6MDM MET C -23 UNP P18708 INITIATING METHIONINE
SEQADV 6MDM GLY C -22 UNP P18708 EXPRESSION TAG
SEQADV 6MDM HIS C -21 UNP P18708 EXPRESSION TAG
SEQADV 6MDM HIS C -20 UNP P18708 EXPRESSION TAG
SEQADV 6MDM HIS C -19 UNP P18708 EXPRESSION TAG
SEQADV 6MDM HIS C -18 UNP P18708 EXPRESSION TAG
SEQADV 6MDM HIS C -17 UNP P18708 EXPRESSION TAG
SEQADV 6MDM HIS C -16 UNP P18708 EXPRESSION TAG
SEQADV 6MDM ASP C -15 UNP P18708 EXPRESSION TAG
SEQADV 6MDM TYR C -14 UNP P18708 EXPRESSION TAG
SEQADV 6MDM ASP C -13 UNP P18708 EXPRESSION TAG
SEQADV 6MDM ILE C -12 UNP P18708 EXPRESSION TAG
SEQADV 6MDM PRO C -11 UNP P18708 EXPRESSION TAG
SEQADV 6MDM THR C -10 UNP P18708 EXPRESSION TAG
SEQADV 6MDM THR C -9 UNP P18708 EXPRESSION TAG
SEQADV 6MDM GLU C -8 UNP P18708 EXPRESSION TAG
SEQADV 6MDM ASN C -7 UNP P18708 EXPRESSION TAG
SEQADV 6MDM LEU C -6 UNP P18708 EXPRESSION TAG
SEQADV 6MDM TYR C -5 UNP P18708 EXPRESSION TAG
SEQADV 6MDM PHE C -4 UNP P18708 EXPRESSION TAG
SEQADV 6MDM GLN C -3 UNP P18708 EXPRESSION TAG
SEQADV 6MDM GLY C -2 UNP P18708 EXPRESSION TAG
SEQADV 6MDM ALA C -1 UNP P18708 EXPRESSION TAG
SEQADV 6MDM HIS C 0 UNP P18708 EXPRESSION TAG
SEQADV 6MDM ILE C 458 UNP P18708 LYS 458 CONFLICT
SEQADV 6MDM MET D -23 UNP P18708 INITIATING METHIONINE
SEQADV 6MDM GLY D -22 UNP P18708 EXPRESSION TAG
SEQADV 6MDM HIS D -21 UNP P18708 EXPRESSION TAG
SEQADV 6MDM HIS D -20 UNP P18708 EXPRESSION TAG
SEQADV 6MDM HIS D -19 UNP P18708 EXPRESSION TAG
SEQADV 6MDM HIS D -18 UNP P18708 EXPRESSION TAG
SEQADV 6MDM HIS D -17 UNP P18708 EXPRESSION TAG
SEQADV 6MDM HIS D -16 UNP P18708 EXPRESSION TAG
SEQADV 6MDM ASP D -15 UNP P18708 EXPRESSION TAG
SEQADV 6MDM TYR D -14 UNP P18708 EXPRESSION TAG
SEQADV 6MDM ASP D -13 UNP P18708 EXPRESSION TAG
SEQADV 6MDM ILE D -12 UNP P18708 EXPRESSION TAG
SEQADV 6MDM PRO D -11 UNP P18708 EXPRESSION TAG
SEQADV 6MDM THR D -10 UNP P18708 EXPRESSION TAG
SEQADV 6MDM THR D -9 UNP P18708 EXPRESSION TAG
SEQADV 6MDM GLU D -8 UNP P18708 EXPRESSION TAG
SEQADV 6MDM ASN D -7 UNP P18708 EXPRESSION TAG
SEQADV 6MDM LEU D -6 UNP P18708 EXPRESSION TAG
SEQADV 6MDM TYR D -5 UNP P18708 EXPRESSION TAG
SEQADV 6MDM PHE D -4 UNP P18708 EXPRESSION TAG
SEQADV 6MDM GLN D -3 UNP P18708 EXPRESSION TAG
SEQADV 6MDM GLY D -2 UNP P18708 EXPRESSION TAG
SEQADV 6MDM ALA D -1 UNP P18708 EXPRESSION TAG
SEQADV 6MDM HIS D 0 UNP P18708 EXPRESSION TAG
SEQADV 6MDM ILE D 458 UNP P18708 LYS 458 CONFLICT
SEQADV 6MDM MET E -23 UNP P18708 INITIATING METHIONINE
SEQADV 6MDM GLY E -22 UNP P18708 EXPRESSION TAG
SEQADV 6MDM HIS E -21 UNP P18708 EXPRESSION TAG
SEQADV 6MDM HIS E -20 UNP P18708 EXPRESSION TAG
SEQADV 6MDM HIS E -19 UNP P18708 EXPRESSION TAG
SEQADV 6MDM HIS E -18 UNP P18708 EXPRESSION TAG
SEQADV 6MDM HIS E -17 UNP P18708 EXPRESSION TAG
SEQADV 6MDM HIS E -16 UNP P18708 EXPRESSION TAG
SEQADV 6MDM ASP E -15 UNP P18708 EXPRESSION TAG
SEQADV 6MDM TYR E -14 UNP P18708 EXPRESSION TAG
SEQADV 6MDM ASP E -13 UNP P18708 EXPRESSION TAG
SEQADV 6MDM ILE E -12 UNP P18708 EXPRESSION TAG
SEQADV 6MDM PRO E -11 UNP P18708 EXPRESSION TAG
SEQADV 6MDM THR E -10 UNP P18708 EXPRESSION TAG
SEQADV 6MDM THR E -9 UNP P18708 EXPRESSION TAG
SEQADV 6MDM GLU E -8 UNP P18708 EXPRESSION TAG
SEQADV 6MDM ASN E -7 UNP P18708 EXPRESSION TAG
SEQADV 6MDM LEU E -6 UNP P18708 EXPRESSION TAG
SEQADV 6MDM TYR E -5 UNP P18708 EXPRESSION TAG
SEQADV 6MDM PHE E -4 UNP P18708 EXPRESSION TAG
SEQADV 6MDM GLN E -3 UNP P18708 EXPRESSION TAG
SEQADV 6MDM GLY E -2 UNP P18708 EXPRESSION TAG
SEQADV 6MDM ALA E -1 UNP P18708 EXPRESSION TAG
SEQADV 6MDM HIS E 0 UNP P18708 EXPRESSION TAG
SEQADV 6MDM ILE E 458 UNP P18708 LYS 458 CONFLICT
SEQADV 6MDM MET F -23 UNP P18708 INITIATING METHIONINE
SEQADV 6MDM GLY F -22 UNP P18708 EXPRESSION TAG
SEQADV 6MDM HIS F -21 UNP P18708 EXPRESSION TAG
SEQADV 6MDM HIS F -20 UNP P18708 EXPRESSION TAG
SEQADV 6MDM HIS F -19 UNP P18708 EXPRESSION TAG
SEQADV 6MDM HIS F -18 UNP P18708 EXPRESSION TAG
SEQADV 6MDM HIS F -17 UNP P18708 EXPRESSION TAG
SEQADV 6MDM HIS F -16 UNP P18708 EXPRESSION TAG
SEQADV 6MDM ASP F -15 UNP P18708 EXPRESSION TAG
SEQADV 6MDM TYR F -14 UNP P18708 EXPRESSION TAG
SEQADV 6MDM ASP F -13 UNP P18708 EXPRESSION TAG
SEQADV 6MDM ILE F -12 UNP P18708 EXPRESSION TAG
SEQADV 6MDM PRO F -11 UNP P18708 EXPRESSION TAG
SEQADV 6MDM THR F -10 UNP P18708 EXPRESSION TAG
SEQADV 6MDM THR F -9 UNP P18708 EXPRESSION TAG
SEQADV 6MDM GLU F -8 UNP P18708 EXPRESSION TAG
SEQADV 6MDM ASN F -7 UNP P18708 EXPRESSION TAG
SEQADV 6MDM LEU F -6 UNP P18708 EXPRESSION TAG
SEQADV 6MDM TYR F -5 UNP P18708 EXPRESSION TAG
SEQADV 6MDM PHE F -4 UNP P18708 EXPRESSION TAG
SEQADV 6MDM GLN F -3 UNP P18708 EXPRESSION TAG
SEQADV 6MDM GLY F -2 UNP P18708 EXPRESSION TAG
SEQADV 6MDM ALA F -1 UNP P18708 EXPRESSION TAG
SEQADV 6MDM HIS F 0 UNP P18708 EXPRESSION TAG
SEQADV 6MDM ILE F 458 UNP P18708 LYS 458 CONFLICT
SEQADV 6MDM MET H -2 UNP P60881 INITIATING METHIONINE
SEQADV 6MDM ALA H -1 UNP P60881 EXPRESSION TAG
SEQADV 6MDM SER H 0 UNP P60881 EXPRESSION TAG
SEQADV 6MDM SER I 145 UNP P32851 CYS 145 CONFLICT
SEQADV 6MDM MET J -27 UNP P63045 INITIATING METHIONINE
SEQADV 6MDM ALA J -26 UNP P63045 EXPRESSION TAG
SEQADV 6MDM SER J -25 UNP P63045 EXPRESSION TAG
SEQADV 6MDM TYR J -24 UNP P63045 EXPRESSION TAG
SEQADV 6MDM TYR J -23 UNP P63045 EXPRESSION TAG
SEQADV 6MDM HIS J -22 UNP P63045 EXPRESSION TAG
SEQADV 6MDM HIS J -21 UNP P63045 EXPRESSION TAG
SEQADV 6MDM HIS J -20 UNP P63045 EXPRESSION TAG
SEQADV 6MDM HIS J -19 UNP P63045 EXPRESSION TAG
SEQADV 6MDM HIS J -18 UNP P63045 EXPRESSION TAG
SEQADV 6MDM HIS J -17 UNP P63045 EXPRESSION TAG
SEQADV 6MDM ASP J -16 UNP P63045 EXPRESSION TAG
SEQADV 6MDM TYR J -15 UNP P63045 EXPRESSION TAG
SEQADV 6MDM ASP J -14 UNP P63045 EXPRESSION TAG
SEQADV 6MDM ILE J -13 UNP P63045 EXPRESSION TAG
SEQADV 6MDM PRO J -12 UNP P63045 EXPRESSION TAG
SEQADV 6MDM THR J -11 UNP P63045 EXPRESSION TAG
SEQADV 6MDM SER J -10 UNP P63045 EXPRESSION TAG
SEQADV 6MDM GLU J -9 UNP P63045 EXPRESSION TAG
SEQADV 6MDM ASN J -8 UNP P63045 EXPRESSION TAG
SEQADV 6MDM LEU J -7 UNP P63045 EXPRESSION TAG
SEQADV 6MDM TYR J -6 UNP P63045 EXPRESSION TAG
SEQADV 6MDM PHE J -5 UNP P63045 EXPRESSION TAG
SEQADV 6MDM GLN J -4 UNP P63045 EXPRESSION TAG
SEQADV 6MDM GLY J -3 UNP P63045 EXPRESSION TAG
SEQADV 6MDM ALA J -2 UNP P63045 EXPRESSION TAG
SEQADV 6MDM SER J -1 UNP P63045 EXPRESSION TAG
SEQADV 6MDM HIS J 0 UNP P63045 EXPRESSION TAG
SEQADV 6MDM MET K -17 UNP P54921 INITIATING METHIONINE
SEQADV 6MDM HIS K -16 UNP P54921 EXPRESSION TAG
SEQADV 6MDM HIS K -15 UNP P54921 EXPRESSION TAG
SEQADV 6MDM HIS K -14 UNP P54921 EXPRESSION TAG
SEQADV 6MDM HIS K -13 UNP P54921 EXPRESSION TAG
SEQADV 6MDM HIS K -12 UNP P54921 EXPRESSION TAG
SEQADV 6MDM HIS K -11 UNP P54921 EXPRESSION TAG
SEQADV 6MDM HIS K -10 UNP P54921 EXPRESSION TAG
SEQADV 6MDM HIS K -9 UNP P54921 EXPRESSION TAG
SEQADV 6MDM HIS K -8 UNP P54921 EXPRESSION TAG
SEQADV 6MDM HIS K -7 UNP P54921 EXPRESSION TAG
SEQADV 6MDM GLU K -6 UNP P54921 EXPRESSION TAG
SEQADV 6MDM ASN K -5 UNP P54921 EXPRESSION TAG
SEQADV 6MDM LEU K -4 UNP P54921 EXPRESSION TAG
SEQADV 6MDM TYR K -3 UNP P54921 EXPRESSION TAG
SEQADV 6MDM PHE K -2 UNP P54921 EXPRESSION TAG
SEQADV 6MDM GLN K -1 UNP P54921 EXPRESSION TAG
SEQADV 6MDM GLY K 0 UNP P54921 EXPRESSION TAG
SEQADV 6MDM MET L -17 UNP P54921 INITIATING METHIONINE
SEQADV 6MDM HIS L -16 UNP P54921 EXPRESSION TAG
SEQADV 6MDM HIS L -15 UNP P54921 EXPRESSION TAG
SEQADV 6MDM HIS L -14 UNP P54921 EXPRESSION TAG
SEQADV 6MDM HIS L -13 UNP P54921 EXPRESSION TAG
SEQADV 6MDM HIS L -12 UNP P54921 EXPRESSION TAG
SEQADV 6MDM HIS L -11 UNP P54921 EXPRESSION TAG
SEQADV 6MDM HIS L -10 UNP P54921 EXPRESSION TAG
SEQADV 6MDM HIS L -9 UNP P54921 EXPRESSION TAG
SEQADV 6MDM HIS L -8 UNP P54921 EXPRESSION TAG
SEQADV 6MDM HIS L -7 UNP P54921 EXPRESSION TAG
SEQADV 6MDM GLU L -6 UNP P54921 EXPRESSION TAG
SEQADV 6MDM ASN L -5 UNP P54921 EXPRESSION TAG
SEQADV 6MDM LEU L -4 UNP P54921 EXPRESSION TAG
SEQADV 6MDM TYR L -3 UNP P54921 EXPRESSION TAG
SEQADV 6MDM PHE L -2 UNP P54921 EXPRESSION TAG
SEQADV 6MDM GLN L -1 UNP P54921 EXPRESSION TAG
SEQADV 6MDM GLY L 0 UNP P54921 EXPRESSION TAG
SEQRES 1 A 768 MET GLY HIS HIS HIS HIS HIS HIS ASP TYR ASP ILE PRO
SEQRES 2 A 768 THR THR GLU ASN LEU TYR PHE GLN GLY ALA HIS MET ALA
SEQRES 3 A 768 GLY ARG SER MET GLN ALA ALA ARG CYS PRO THR ASP GLU
SEQRES 4 A 768 LEU SER LEU SER ASN CYS ALA VAL VAL SER GLU LYS ASP
SEQRES 5 A 768 TYR GLN SER GLY GLN HIS VAL ILE VAL ARG THR SER PRO
SEQRES 6 A 768 ASN HIS LYS TYR ILE PHE THR LEU ARG THR HIS PRO SER
SEQRES 7 A 768 VAL VAL PRO GLY SER VAL ALA PHE SER LEU PRO GLN ARG
SEQRES 8 A 768 LYS TRP ALA GLY LEU SER ILE GLY GLN GLU ILE GLU VAL
SEQRES 9 A 768 ALA LEU TYR SER PHE ASP LYS ALA LYS GLN CYS ILE GLY
SEQRES 10 A 768 THR MET THR ILE GLU ILE ASP PHE LEU GLN LYS LYS ASN
SEQRES 11 A 768 ILE ASP SER ASN PRO TYR ASP THR ASP LYS MET ALA ALA
SEQRES 12 A 768 GLU PHE ILE GLN GLN PHE ASN ASN GLN ALA PHE SER VAL
SEQRES 13 A 768 GLY GLN GLN LEU VAL PHE SER PHE ASN ASP LYS LEU PHE
SEQRES 14 A 768 GLY LEU LEU VAL LYS ASP ILE GLU ALA MET ASP PRO SER
SEQRES 15 A 768 ILE LEU LYS GLY GLU PRO ALA SER GLY LYS ARG GLN LYS
SEQRES 16 A 768 ILE GLU VAL GLY LEU VAL VAL GLY ASN SER GLN VAL ALA
SEQRES 17 A 768 PHE GLU LYS ALA GLU ASN SER SER LEU ASN LEU ILE GLY
SEQRES 18 A 768 LYS ALA LYS THR LYS GLU ASN ARG GLN SER ILE ILE ASN
SEQRES 19 A 768 PRO ASP TRP ASN PHE GLU LYS MET GLY ILE GLY GLY LEU
SEQRES 20 A 768 ASP LYS GLU PHE SER ASP ILE PHE ARG ARG ALA PHE ALA
SEQRES 21 A 768 SER ARG VAL PHE PRO PRO GLU ILE VAL GLU GLN MET GLY
SEQRES 22 A 768 CYS LYS HIS VAL LYS GLY ILE LEU LEU TYR GLY PRO PRO
SEQRES 23 A 768 GLY CYS GLY LYS THR LEU LEU ALA ARG GLN ILE GLY LYS
SEQRES 24 A 768 MET LEU ASN ALA ARG GLU PRO LYS VAL VAL ASN GLY PRO
SEQRES 25 A 768 GLU ILE LEU ASN LYS TYR VAL GLY GLU SER GLU ALA ASN
SEQRES 26 A 768 ILE ARG LYS LEU PHE ALA ASP ALA GLU GLU GLU GLN ARG
SEQRES 27 A 768 ARG LEU GLY ALA ASN SER GLY LEU HIS ILE ILE ILE PHE
SEQRES 28 A 768 ASP GLU ILE ASP ALA ILE CYS LYS GLN ARG GLY SER MET
SEQRES 29 A 768 ALA GLY SER THR GLY VAL HIS ASP THR VAL VAL ASN GLN
SEQRES 30 A 768 LEU LEU SER LYS ILE ASP GLY VAL GLU GLN LEU ASN ASN
SEQRES 31 A 768 ILE LEU VAL ILE GLY MET THR ASN ARG PRO ASP LEU ILE
SEQRES 32 A 768 ASP GLU ALA LEU LEU ARG PRO GLY ARG LEU GLU VAL LYS
SEQRES 33 A 768 MET GLU ILE GLY LEU PRO ASP GLU LYS GLY ARG LEU GLN
SEQRES 34 A 768 ILE LEU HIS ILE HIS THR ALA ARG MET ARG GLY HIS GLN
SEQRES 35 A 768 LEU LEU SER ALA ASP VAL ASP ILE LYS GLU LEU ALA VAL
SEQRES 36 A 768 GLU THR LYS ASN PHE SER GLY ALA GLU LEU GLU GLY LEU
SEQRES 37 A 768 VAL ARG ALA ALA GLN SER THR ALA MET ASN ARG HIS ILE
SEQRES 38 A 768 ILE ALA SER THR LYS VAL GLU VAL ASP MET GLU LYS ALA
SEQRES 39 A 768 GLU SER LEU GLN VAL THR ARG GLY ASP PHE LEU ALA SER
SEQRES 40 A 768 LEU GLU ASN ASP ILE LYS PRO ALA PHE GLY THR ASN GLN
SEQRES 41 A 768 GLU ASP TYR ALA SER TYR ILE MET ASN GLY ILE ILE LYS
SEQRES 42 A 768 TRP GLY ASP PRO VAL THR ARG VAL LEU ASP ASP GLY GLU
SEQRES 43 A 768 LEU LEU VAL GLN GLN THR LYS ASN SER ASP ARG THR PRO
SEQRES 44 A 768 LEU VAL SER VAL LEU LEU GLU GLY PRO PRO HIS SER GLY
SEQRES 45 A 768 LYS THR ALA LEU ALA ALA LYS ILE ALA GLU GLU SER ASN
SEQRES 46 A 768 PHE PRO PHE ILE LYS ILE CYS SER PRO ASP LYS MET ILE
SEQRES 47 A 768 GLY PHE SER GLU THR ALA LYS CYS GLN ALA MET LYS LYS
SEQRES 48 A 768 ILE PHE ASP ASP ALA TYR LYS SER GLN LEU SER CYS VAL
SEQRES 49 A 768 VAL VAL ASP ASP ILE GLU ARG LEU LEU ASP TYR VAL PRO
SEQRES 50 A 768 ILE GLY PRO ARG PHE SER ASN LEU VAL LEU GLN ALA LEU
SEQRES 51 A 768 LEU VAL LEU LEU LYS LYS ALA PRO PRO GLN GLY ARG LYS
SEQRES 52 A 768 LEU LEU ILE ILE GLY THR THR SER ARG LYS ASP VAL LEU
SEQRES 53 A 768 GLN GLU MET GLU MET LEU ASN ALA PHE SER THR THR ILE
SEQRES 54 A 768 HIS VAL PRO ASN ILE ALA THR GLY GLU GLN LEU LEU GLU
SEQRES 55 A 768 ALA LEU GLU LEU LEU GLY ASN PHE LYS ASP LYS GLU ARG
SEQRES 56 A 768 THR THR ILE ALA GLN GLN VAL LYS GLY LYS LYS VAL TRP
SEQRES 57 A 768 ILE GLY ILE LYS LYS LEU LEU MET LEU ILE GLU MET SER
SEQRES 58 A 768 LEU GLN MET ASP PRO GLU TYR ARG VAL ARG LYS PHE LEU
SEQRES 59 A 768 ALA LEU LEU ARG GLU GLU GLY ALA SER PRO LEU ASP PHE
SEQRES 60 A 768 ASP
SEQRES 1 B 768 MET GLY HIS HIS HIS HIS HIS HIS ASP TYR ASP ILE PRO
SEQRES 2 B 768 THR THR GLU ASN LEU TYR PHE GLN GLY ALA HIS MET ALA
SEQRES 3 B 768 GLY ARG SER MET GLN ALA ALA ARG CYS PRO THR ASP GLU
SEQRES 4 B 768 LEU SER LEU SER ASN CYS ALA VAL VAL SER GLU LYS ASP
SEQRES 5 B 768 TYR GLN SER GLY GLN HIS VAL ILE VAL ARG THR SER PRO
SEQRES 6 B 768 ASN HIS LYS TYR ILE PHE THR LEU ARG THR HIS PRO SER
SEQRES 7 B 768 VAL VAL PRO GLY SER VAL ALA PHE SER LEU PRO GLN ARG
SEQRES 8 B 768 LYS TRP ALA GLY LEU SER ILE GLY GLN GLU ILE GLU VAL
SEQRES 9 B 768 ALA LEU TYR SER PHE ASP LYS ALA LYS GLN CYS ILE GLY
SEQRES 10 B 768 THR MET THR ILE GLU ILE ASP PHE LEU GLN LYS LYS ASN
SEQRES 11 B 768 ILE ASP SER ASN PRO TYR ASP THR ASP LYS MET ALA ALA
SEQRES 12 B 768 GLU PHE ILE GLN GLN PHE ASN ASN GLN ALA PHE SER VAL
SEQRES 13 B 768 GLY GLN GLN LEU VAL PHE SER PHE ASN ASP LYS LEU PHE
SEQRES 14 B 768 GLY LEU LEU VAL LYS ASP ILE GLU ALA MET ASP PRO SER
SEQRES 15 B 768 ILE LEU LYS GLY GLU PRO ALA SER GLY LYS ARG GLN LYS
SEQRES 16 B 768 ILE GLU VAL GLY LEU VAL VAL GLY ASN SER GLN VAL ALA
SEQRES 17 B 768 PHE GLU LYS ALA GLU ASN SER SER LEU ASN LEU ILE GLY
SEQRES 18 B 768 LYS ALA LYS THR LYS GLU ASN ARG GLN SER ILE ILE ASN
SEQRES 19 B 768 PRO ASP TRP ASN PHE GLU LYS MET GLY ILE GLY GLY LEU
SEQRES 20 B 768 ASP LYS GLU PHE SER ASP ILE PHE ARG ARG ALA PHE ALA
SEQRES 21 B 768 SER ARG VAL PHE PRO PRO GLU ILE VAL GLU GLN MET GLY
SEQRES 22 B 768 CYS LYS HIS VAL LYS GLY ILE LEU LEU TYR GLY PRO PRO
SEQRES 23 B 768 GLY CYS GLY LYS THR LEU LEU ALA ARG GLN ILE GLY LYS
SEQRES 24 B 768 MET LEU ASN ALA ARG GLU PRO LYS VAL VAL ASN GLY PRO
SEQRES 25 B 768 GLU ILE LEU ASN LYS TYR VAL GLY GLU SER GLU ALA ASN
SEQRES 26 B 768 ILE ARG LYS LEU PHE ALA ASP ALA GLU GLU GLU GLN ARG
SEQRES 27 B 768 ARG LEU GLY ALA ASN SER GLY LEU HIS ILE ILE ILE PHE
SEQRES 28 B 768 ASP GLU ILE ASP ALA ILE CYS LYS GLN ARG GLY SER MET
SEQRES 29 B 768 ALA GLY SER THR GLY VAL HIS ASP THR VAL VAL ASN GLN
SEQRES 30 B 768 LEU LEU SER LYS ILE ASP GLY VAL GLU GLN LEU ASN ASN
SEQRES 31 B 768 ILE LEU VAL ILE GLY MET THR ASN ARG PRO ASP LEU ILE
SEQRES 32 B 768 ASP GLU ALA LEU LEU ARG PRO GLY ARG LEU GLU VAL LYS
SEQRES 33 B 768 MET GLU ILE GLY LEU PRO ASP GLU LYS GLY ARG LEU GLN
SEQRES 34 B 768 ILE LEU HIS ILE HIS THR ALA ARG MET ARG GLY HIS GLN
SEQRES 35 B 768 LEU LEU SER ALA ASP VAL ASP ILE LYS GLU LEU ALA VAL
SEQRES 36 B 768 GLU THR LYS ASN PHE SER GLY ALA GLU LEU GLU GLY LEU
SEQRES 37 B 768 VAL ARG ALA ALA GLN SER THR ALA MET ASN ARG HIS ILE
SEQRES 38 B 768 ILE ALA SER THR LYS VAL GLU VAL ASP MET GLU LYS ALA
SEQRES 39 B 768 GLU SER LEU GLN VAL THR ARG GLY ASP PHE LEU ALA SER
SEQRES 40 B 768 LEU GLU ASN ASP ILE LYS PRO ALA PHE GLY THR ASN GLN
SEQRES 41 B 768 GLU ASP TYR ALA SER TYR ILE MET ASN GLY ILE ILE LYS
SEQRES 42 B 768 TRP GLY ASP PRO VAL THR ARG VAL LEU ASP ASP GLY GLU
SEQRES 43 B 768 LEU LEU VAL GLN GLN THR LYS ASN SER ASP ARG THR PRO
SEQRES 44 B 768 LEU VAL SER VAL LEU LEU GLU GLY PRO PRO HIS SER GLY
SEQRES 45 B 768 LYS THR ALA LEU ALA ALA LYS ILE ALA GLU GLU SER ASN
SEQRES 46 B 768 PHE PRO PHE ILE LYS ILE CYS SER PRO ASP LYS MET ILE
SEQRES 47 B 768 GLY PHE SER GLU THR ALA LYS CYS GLN ALA MET LYS LYS
SEQRES 48 B 768 ILE PHE ASP ASP ALA TYR LYS SER GLN LEU SER CYS VAL
SEQRES 49 B 768 VAL VAL ASP ASP ILE GLU ARG LEU LEU ASP TYR VAL PRO
SEQRES 50 B 768 ILE GLY PRO ARG PHE SER ASN LEU VAL LEU GLN ALA LEU
SEQRES 51 B 768 LEU VAL LEU LEU LYS LYS ALA PRO PRO GLN GLY ARG LYS
SEQRES 52 B 768 LEU LEU ILE ILE GLY THR THR SER ARG LYS ASP VAL LEU
SEQRES 53 B 768 GLN GLU MET GLU MET LEU ASN ALA PHE SER THR THR ILE
SEQRES 54 B 768 HIS VAL PRO ASN ILE ALA THR GLY GLU GLN LEU LEU GLU
SEQRES 55 B 768 ALA LEU GLU LEU LEU GLY ASN PHE LYS ASP LYS GLU ARG
SEQRES 56 B 768 THR THR ILE ALA GLN GLN VAL LYS GLY LYS LYS VAL TRP
SEQRES 57 B 768 ILE GLY ILE LYS LYS LEU LEU MET LEU ILE GLU MET SER
SEQRES 58 B 768 LEU GLN MET ASP PRO GLU TYR ARG VAL ARG LYS PHE LEU
SEQRES 59 B 768 ALA LEU LEU ARG GLU GLU GLY ALA SER PRO LEU ASP PHE
SEQRES 60 B 768 ASP
SEQRES 1 C 768 MET GLY HIS HIS HIS HIS HIS HIS ASP TYR ASP ILE PRO
SEQRES 2 C 768 THR THR GLU ASN LEU TYR PHE GLN GLY ALA HIS MET ALA
SEQRES 3 C 768 GLY ARG SER MET GLN ALA ALA ARG CYS PRO THR ASP GLU
SEQRES 4 C 768 LEU SER LEU SER ASN CYS ALA VAL VAL SER GLU LYS ASP
SEQRES 5 C 768 TYR GLN SER GLY GLN HIS VAL ILE VAL ARG THR SER PRO
SEQRES 6 C 768 ASN HIS LYS TYR ILE PHE THR LEU ARG THR HIS PRO SER
SEQRES 7 C 768 VAL VAL PRO GLY SER VAL ALA PHE SER LEU PRO GLN ARG
SEQRES 8 C 768 LYS TRP ALA GLY LEU SER ILE GLY GLN GLU ILE GLU VAL
SEQRES 9 C 768 ALA LEU TYR SER PHE ASP LYS ALA LYS GLN CYS ILE GLY
SEQRES 10 C 768 THR MET THR ILE GLU ILE ASP PHE LEU GLN LYS LYS ASN
SEQRES 11 C 768 ILE ASP SER ASN PRO TYR ASP THR ASP LYS MET ALA ALA
SEQRES 12 C 768 GLU PHE ILE GLN GLN PHE ASN ASN GLN ALA PHE SER VAL
SEQRES 13 C 768 GLY GLN GLN LEU VAL PHE SER PHE ASN ASP LYS LEU PHE
SEQRES 14 C 768 GLY LEU LEU VAL LYS ASP ILE GLU ALA MET ASP PRO SER
SEQRES 15 C 768 ILE LEU LYS GLY GLU PRO ALA SER GLY LYS ARG GLN LYS
SEQRES 16 C 768 ILE GLU VAL GLY LEU VAL VAL GLY ASN SER GLN VAL ALA
SEQRES 17 C 768 PHE GLU LYS ALA GLU ASN SER SER LEU ASN LEU ILE GLY
SEQRES 18 C 768 LYS ALA LYS THR LYS GLU ASN ARG GLN SER ILE ILE ASN
SEQRES 19 C 768 PRO ASP TRP ASN PHE GLU LYS MET GLY ILE GLY GLY LEU
SEQRES 20 C 768 ASP LYS GLU PHE SER ASP ILE PHE ARG ARG ALA PHE ALA
SEQRES 21 C 768 SER ARG VAL PHE PRO PRO GLU ILE VAL GLU GLN MET GLY
SEQRES 22 C 768 CYS LYS HIS VAL LYS GLY ILE LEU LEU TYR GLY PRO PRO
SEQRES 23 C 768 GLY CYS GLY LYS THR LEU LEU ALA ARG GLN ILE GLY LYS
SEQRES 24 C 768 MET LEU ASN ALA ARG GLU PRO LYS VAL VAL ASN GLY PRO
SEQRES 25 C 768 GLU ILE LEU ASN LYS TYR VAL GLY GLU SER GLU ALA ASN
SEQRES 26 C 768 ILE ARG LYS LEU PHE ALA ASP ALA GLU GLU GLU GLN ARG
SEQRES 27 C 768 ARG LEU GLY ALA ASN SER GLY LEU HIS ILE ILE ILE PHE
SEQRES 28 C 768 ASP GLU ILE ASP ALA ILE CYS LYS GLN ARG GLY SER MET
SEQRES 29 C 768 ALA GLY SER THR GLY VAL HIS ASP THR VAL VAL ASN GLN
SEQRES 30 C 768 LEU LEU SER LYS ILE ASP GLY VAL GLU GLN LEU ASN ASN
SEQRES 31 C 768 ILE LEU VAL ILE GLY MET THR ASN ARG PRO ASP LEU ILE
SEQRES 32 C 768 ASP GLU ALA LEU LEU ARG PRO GLY ARG LEU GLU VAL LYS
SEQRES 33 C 768 MET GLU ILE GLY LEU PRO ASP GLU LYS GLY ARG LEU GLN
SEQRES 34 C 768 ILE LEU HIS ILE HIS THR ALA ARG MET ARG GLY HIS GLN
SEQRES 35 C 768 LEU LEU SER ALA ASP VAL ASP ILE LYS GLU LEU ALA VAL
SEQRES 36 C 768 GLU THR LYS ASN PHE SER GLY ALA GLU LEU GLU GLY LEU
SEQRES 37 C 768 VAL ARG ALA ALA GLN SER THR ALA MET ASN ARG HIS ILE
SEQRES 38 C 768 ILE ALA SER THR LYS VAL GLU VAL ASP MET GLU LYS ALA
SEQRES 39 C 768 GLU SER LEU GLN VAL THR ARG GLY ASP PHE LEU ALA SER
SEQRES 40 C 768 LEU GLU ASN ASP ILE LYS PRO ALA PHE GLY THR ASN GLN
SEQRES 41 C 768 GLU ASP TYR ALA SER TYR ILE MET ASN GLY ILE ILE LYS
SEQRES 42 C 768 TRP GLY ASP PRO VAL THR ARG VAL LEU ASP ASP GLY GLU
SEQRES 43 C 768 LEU LEU VAL GLN GLN THR LYS ASN SER ASP ARG THR PRO
SEQRES 44 C 768 LEU VAL SER VAL LEU LEU GLU GLY PRO PRO HIS SER GLY
SEQRES 45 C 768 LYS THR ALA LEU ALA ALA LYS ILE ALA GLU GLU SER ASN
SEQRES 46 C 768 PHE PRO PHE ILE LYS ILE CYS SER PRO ASP LYS MET ILE
SEQRES 47 C 768 GLY PHE SER GLU THR ALA LYS CYS GLN ALA MET LYS LYS
SEQRES 48 C 768 ILE PHE ASP ASP ALA TYR LYS SER GLN LEU SER CYS VAL
SEQRES 49 C 768 VAL VAL ASP ASP ILE GLU ARG LEU LEU ASP TYR VAL PRO
SEQRES 50 C 768 ILE GLY PRO ARG PHE SER ASN LEU VAL LEU GLN ALA LEU
SEQRES 51 C 768 LEU VAL LEU LEU LYS LYS ALA PRO PRO GLN GLY ARG LYS
SEQRES 52 C 768 LEU LEU ILE ILE GLY THR THR SER ARG LYS ASP VAL LEU
SEQRES 53 C 768 GLN GLU MET GLU MET LEU ASN ALA PHE SER THR THR ILE
SEQRES 54 C 768 HIS VAL PRO ASN ILE ALA THR GLY GLU GLN LEU LEU GLU
SEQRES 55 C 768 ALA LEU GLU LEU LEU GLY ASN PHE LYS ASP LYS GLU ARG
SEQRES 56 C 768 THR THR ILE ALA GLN GLN VAL LYS GLY LYS LYS VAL TRP
SEQRES 57 C 768 ILE GLY ILE LYS LYS LEU LEU MET LEU ILE GLU MET SER
SEQRES 58 C 768 LEU GLN MET ASP PRO GLU TYR ARG VAL ARG LYS PHE LEU
SEQRES 59 C 768 ALA LEU LEU ARG GLU GLU GLY ALA SER PRO LEU ASP PHE
SEQRES 60 C 768 ASP
SEQRES 1 D 768 MET GLY HIS HIS HIS HIS HIS HIS ASP TYR ASP ILE PRO
SEQRES 2 D 768 THR THR GLU ASN LEU TYR PHE GLN GLY ALA HIS MET ALA
SEQRES 3 D 768 GLY ARG SER MET GLN ALA ALA ARG CYS PRO THR ASP GLU
SEQRES 4 D 768 LEU SER LEU SER ASN CYS ALA VAL VAL SER GLU LYS ASP
SEQRES 5 D 768 TYR GLN SER GLY GLN HIS VAL ILE VAL ARG THR SER PRO
SEQRES 6 D 768 ASN HIS LYS TYR ILE PHE THR LEU ARG THR HIS PRO SER
SEQRES 7 D 768 VAL VAL PRO GLY SER VAL ALA PHE SER LEU PRO GLN ARG
SEQRES 8 D 768 LYS TRP ALA GLY LEU SER ILE GLY GLN GLU ILE GLU VAL
SEQRES 9 D 768 ALA LEU TYR SER PHE ASP LYS ALA LYS GLN CYS ILE GLY
SEQRES 10 D 768 THR MET THR ILE GLU ILE ASP PHE LEU GLN LYS LYS ASN
SEQRES 11 D 768 ILE ASP SER ASN PRO TYR ASP THR ASP LYS MET ALA ALA
SEQRES 12 D 768 GLU PHE ILE GLN GLN PHE ASN ASN GLN ALA PHE SER VAL
SEQRES 13 D 768 GLY GLN GLN LEU VAL PHE SER PHE ASN ASP LYS LEU PHE
SEQRES 14 D 768 GLY LEU LEU VAL LYS ASP ILE GLU ALA MET ASP PRO SER
SEQRES 15 D 768 ILE LEU LYS GLY GLU PRO ALA SER GLY LYS ARG GLN LYS
SEQRES 16 D 768 ILE GLU VAL GLY LEU VAL VAL GLY ASN SER GLN VAL ALA
SEQRES 17 D 768 PHE GLU LYS ALA GLU ASN SER SER LEU ASN LEU ILE GLY
SEQRES 18 D 768 LYS ALA LYS THR LYS GLU ASN ARG GLN SER ILE ILE ASN
SEQRES 19 D 768 PRO ASP TRP ASN PHE GLU LYS MET GLY ILE GLY GLY LEU
SEQRES 20 D 768 ASP LYS GLU PHE SER ASP ILE PHE ARG ARG ALA PHE ALA
SEQRES 21 D 768 SER ARG VAL PHE PRO PRO GLU ILE VAL GLU GLN MET GLY
SEQRES 22 D 768 CYS LYS HIS VAL LYS GLY ILE LEU LEU TYR GLY PRO PRO
SEQRES 23 D 768 GLY CYS GLY LYS THR LEU LEU ALA ARG GLN ILE GLY LYS
SEQRES 24 D 768 MET LEU ASN ALA ARG GLU PRO LYS VAL VAL ASN GLY PRO
SEQRES 25 D 768 GLU ILE LEU ASN LYS TYR VAL GLY GLU SER GLU ALA ASN
SEQRES 26 D 768 ILE ARG LYS LEU PHE ALA ASP ALA GLU GLU GLU GLN ARG
SEQRES 27 D 768 ARG LEU GLY ALA ASN SER GLY LEU HIS ILE ILE ILE PHE
SEQRES 28 D 768 ASP GLU ILE ASP ALA ILE CYS LYS GLN ARG GLY SER MET
SEQRES 29 D 768 ALA GLY SER THR GLY VAL HIS ASP THR VAL VAL ASN GLN
SEQRES 30 D 768 LEU LEU SER LYS ILE ASP GLY VAL GLU GLN LEU ASN ASN
SEQRES 31 D 768 ILE LEU VAL ILE GLY MET THR ASN ARG PRO ASP LEU ILE
SEQRES 32 D 768 ASP GLU ALA LEU LEU ARG PRO GLY ARG LEU GLU VAL LYS
SEQRES 33 D 768 MET GLU ILE GLY LEU PRO ASP GLU LYS GLY ARG LEU GLN
SEQRES 34 D 768 ILE LEU HIS ILE HIS THR ALA ARG MET ARG GLY HIS GLN
SEQRES 35 D 768 LEU LEU SER ALA ASP VAL ASP ILE LYS GLU LEU ALA VAL
SEQRES 36 D 768 GLU THR LYS ASN PHE SER GLY ALA GLU LEU GLU GLY LEU
SEQRES 37 D 768 VAL ARG ALA ALA GLN SER THR ALA MET ASN ARG HIS ILE
SEQRES 38 D 768 ILE ALA SER THR LYS VAL GLU VAL ASP MET GLU LYS ALA
SEQRES 39 D 768 GLU SER LEU GLN VAL THR ARG GLY ASP PHE LEU ALA SER
SEQRES 40 D 768 LEU GLU ASN ASP ILE LYS PRO ALA PHE GLY THR ASN GLN
SEQRES 41 D 768 GLU ASP TYR ALA SER TYR ILE MET ASN GLY ILE ILE LYS
SEQRES 42 D 768 TRP GLY ASP PRO VAL THR ARG VAL LEU ASP ASP GLY GLU
SEQRES 43 D 768 LEU LEU VAL GLN GLN THR LYS ASN SER ASP ARG THR PRO
SEQRES 44 D 768 LEU VAL SER VAL LEU LEU GLU GLY PRO PRO HIS SER GLY
SEQRES 45 D 768 LYS THR ALA LEU ALA ALA LYS ILE ALA GLU GLU SER ASN
SEQRES 46 D 768 PHE PRO PHE ILE LYS ILE CYS SER PRO ASP LYS MET ILE
SEQRES 47 D 768 GLY PHE SER GLU THR ALA LYS CYS GLN ALA MET LYS LYS
SEQRES 48 D 768 ILE PHE ASP ASP ALA TYR LYS SER GLN LEU SER CYS VAL
SEQRES 49 D 768 VAL VAL ASP ASP ILE GLU ARG LEU LEU ASP TYR VAL PRO
SEQRES 50 D 768 ILE GLY PRO ARG PHE SER ASN LEU VAL LEU GLN ALA LEU
SEQRES 51 D 768 LEU VAL LEU LEU LYS LYS ALA PRO PRO GLN GLY ARG LYS
SEQRES 52 D 768 LEU LEU ILE ILE GLY THR THR SER ARG LYS ASP VAL LEU
SEQRES 53 D 768 GLN GLU MET GLU MET LEU ASN ALA PHE SER THR THR ILE
SEQRES 54 D 768 HIS VAL PRO ASN ILE ALA THR GLY GLU GLN LEU LEU GLU
SEQRES 55 D 768 ALA LEU GLU LEU LEU GLY ASN PHE LYS ASP LYS GLU ARG
SEQRES 56 D 768 THR THR ILE ALA GLN GLN VAL LYS GLY LYS LYS VAL TRP
SEQRES 57 D 768 ILE GLY ILE LYS LYS LEU LEU MET LEU ILE GLU MET SER
SEQRES 58 D 768 LEU GLN MET ASP PRO GLU TYR ARG VAL ARG LYS PHE LEU
SEQRES 59 D 768 ALA LEU LEU ARG GLU GLU GLY ALA SER PRO LEU ASP PHE
SEQRES 60 D 768 ASP
SEQRES 1 E 768 MET GLY HIS HIS HIS HIS HIS HIS ASP TYR ASP ILE PRO
SEQRES 2 E 768 THR THR GLU ASN LEU TYR PHE GLN GLY ALA HIS MET ALA
SEQRES 3 E 768 GLY ARG SER MET GLN ALA ALA ARG CYS PRO THR ASP GLU
SEQRES 4 E 768 LEU SER LEU SER ASN CYS ALA VAL VAL SER GLU LYS ASP
SEQRES 5 E 768 TYR GLN SER GLY GLN HIS VAL ILE VAL ARG THR SER PRO
SEQRES 6 E 768 ASN HIS LYS TYR ILE PHE THR LEU ARG THR HIS PRO SER
SEQRES 7 E 768 VAL VAL PRO GLY SER VAL ALA PHE SER LEU PRO GLN ARG
SEQRES 8 E 768 LYS TRP ALA GLY LEU SER ILE GLY GLN GLU ILE GLU VAL
SEQRES 9 E 768 ALA LEU TYR SER PHE ASP LYS ALA LYS GLN CYS ILE GLY
SEQRES 10 E 768 THR MET THR ILE GLU ILE ASP PHE LEU GLN LYS LYS ASN
SEQRES 11 E 768 ILE ASP SER ASN PRO TYR ASP THR ASP LYS MET ALA ALA
SEQRES 12 E 768 GLU PHE ILE GLN GLN PHE ASN ASN GLN ALA PHE SER VAL
SEQRES 13 E 768 GLY GLN GLN LEU VAL PHE SER PHE ASN ASP LYS LEU PHE
SEQRES 14 E 768 GLY LEU LEU VAL LYS ASP ILE GLU ALA MET ASP PRO SER
SEQRES 15 E 768 ILE LEU LYS GLY GLU PRO ALA SER GLY LYS ARG GLN LYS
SEQRES 16 E 768 ILE GLU VAL GLY LEU VAL VAL GLY ASN SER GLN VAL ALA
SEQRES 17 E 768 PHE GLU LYS ALA GLU ASN SER SER LEU ASN LEU ILE GLY
SEQRES 18 E 768 LYS ALA LYS THR LYS GLU ASN ARG GLN SER ILE ILE ASN
SEQRES 19 E 768 PRO ASP TRP ASN PHE GLU LYS MET GLY ILE GLY GLY LEU
SEQRES 20 E 768 ASP LYS GLU PHE SER ASP ILE PHE ARG ARG ALA PHE ALA
SEQRES 21 E 768 SER ARG VAL PHE PRO PRO GLU ILE VAL GLU GLN MET GLY
SEQRES 22 E 768 CYS LYS HIS VAL LYS GLY ILE LEU LEU TYR GLY PRO PRO
SEQRES 23 E 768 GLY CYS GLY LYS THR LEU LEU ALA ARG GLN ILE GLY LYS
SEQRES 24 E 768 MET LEU ASN ALA ARG GLU PRO LYS VAL VAL ASN GLY PRO
SEQRES 25 E 768 GLU ILE LEU ASN LYS TYR VAL GLY GLU SER GLU ALA ASN
SEQRES 26 E 768 ILE ARG LYS LEU PHE ALA ASP ALA GLU GLU GLU GLN ARG
SEQRES 27 E 768 ARG LEU GLY ALA ASN SER GLY LEU HIS ILE ILE ILE PHE
SEQRES 28 E 768 ASP GLU ILE ASP ALA ILE CYS LYS GLN ARG GLY SER MET
SEQRES 29 E 768 ALA GLY SER THR GLY VAL HIS ASP THR VAL VAL ASN GLN
SEQRES 30 E 768 LEU LEU SER LYS ILE ASP GLY VAL GLU GLN LEU ASN ASN
SEQRES 31 E 768 ILE LEU VAL ILE GLY MET THR ASN ARG PRO ASP LEU ILE
SEQRES 32 E 768 ASP GLU ALA LEU LEU ARG PRO GLY ARG LEU GLU VAL LYS
SEQRES 33 E 768 MET GLU ILE GLY LEU PRO ASP GLU LYS GLY ARG LEU GLN
SEQRES 34 E 768 ILE LEU HIS ILE HIS THR ALA ARG MET ARG GLY HIS GLN
SEQRES 35 E 768 LEU LEU SER ALA ASP VAL ASP ILE LYS GLU LEU ALA VAL
SEQRES 36 E 768 GLU THR LYS ASN PHE SER GLY ALA GLU LEU GLU GLY LEU
SEQRES 37 E 768 VAL ARG ALA ALA GLN SER THR ALA MET ASN ARG HIS ILE
SEQRES 38 E 768 ILE ALA SER THR LYS VAL GLU VAL ASP MET GLU LYS ALA
SEQRES 39 E 768 GLU SER LEU GLN VAL THR ARG GLY ASP PHE LEU ALA SER
SEQRES 40 E 768 LEU GLU ASN ASP ILE LYS PRO ALA PHE GLY THR ASN GLN
SEQRES 41 E 768 GLU ASP TYR ALA SER TYR ILE MET ASN GLY ILE ILE LYS
SEQRES 42 E 768 TRP GLY ASP PRO VAL THR ARG VAL LEU ASP ASP GLY GLU
SEQRES 43 E 768 LEU LEU VAL GLN GLN THR LYS ASN SER ASP ARG THR PRO
SEQRES 44 E 768 LEU VAL SER VAL LEU LEU GLU GLY PRO PRO HIS SER GLY
SEQRES 45 E 768 LYS THR ALA LEU ALA ALA LYS ILE ALA GLU GLU SER ASN
SEQRES 46 E 768 PHE PRO PHE ILE LYS ILE CYS SER PRO ASP LYS MET ILE
SEQRES 47 E 768 GLY PHE SER GLU THR ALA LYS CYS GLN ALA MET LYS LYS
SEQRES 48 E 768 ILE PHE ASP ASP ALA TYR LYS SER GLN LEU SER CYS VAL
SEQRES 49 E 768 VAL VAL ASP ASP ILE GLU ARG LEU LEU ASP TYR VAL PRO
SEQRES 50 E 768 ILE GLY PRO ARG PHE SER ASN LEU VAL LEU GLN ALA LEU
SEQRES 51 E 768 LEU VAL LEU LEU LYS LYS ALA PRO PRO GLN GLY ARG LYS
SEQRES 52 E 768 LEU LEU ILE ILE GLY THR THR SER ARG LYS ASP VAL LEU
SEQRES 53 E 768 GLN GLU MET GLU MET LEU ASN ALA PHE SER THR THR ILE
SEQRES 54 E 768 HIS VAL PRO ASN ILE ALA THR GLY GLU GLN LEU LEU GLU
SEQRES 55 E 768 ALA LEU GLU LEU LEU GLY ASN PHE LYS ASP LYS GLU ARG
SEQRES 56 E 768 THR THR ILE ALA GLN GLN VAL LYS GLY LYS LYS VAL TRP
SEQRES 57 E 768 ILE GLY ILE LYS LYS LEU LEU MET LEU ILE GLU MET SER
SEQRES 58 E 768 LEU GLN MET ASP PRO GLU TYR ARG VAL ARG LYS PHE LEU
SEQRES 59 E 768 ALA LEU LEU ARG GLU GLU GLY ALA SER PRO LEU ASP PHE
SEQRES 60 E 768 ASP
SEQRES 1 F 768 MET GLY HIS HIS HIS HIS HIS HIS ASP TYR ASP ILE PRO
SEQRES 2 F 768 THR THR GLU ASN LEU TYR PHE GLN GLY ALA HIS MET ALA
SEQRES 3 F 768 GLY ARG SER MET GLN ALA ALA ARG CYS PRO THR ASP GLU
SEQRES 4 F 768 LEU SER LEU SER ASN CYS ALA VAL VAL SER GLU LYS ASP
SEQRES 5 F 768 TYR GLN SER GLY GLN HIS VAL ILE VAL ARG THR SER PRO
SEQRES 6 F 768 ASN HIS LYS TYR ILE PHE THR LEU ARG THR HIS PRO SER
SEQRES 7 F 768 VAL VAL PRO GLY SER VAL ALA PHE SER LEU PRO GLN ARG
SEQRES 8 F 768 LYS TRP ALA GLY LEU SER ILE GLY GLN GLU ILE GLU VAL
SEQRES 9 F 768 ALA LEU TYR SER PHE ASP LYS ALA LYS GLN CYS ILE GLY
SEQRES 10 F 768 THR MET THR ILE GLU ILE ASP PHE LEU GLN LYS LYS ASN
SEQRES 11 F 768 ILE ASP SER ASN PRO TYR ASP THR ASP LYS MET ALA ALA
SEQRES 12 F 768 GLU PHE ILE GLN GLN PHE ASN ASN GLN ALA PHE SER VAL
SEQRES 13 F 768 GLY GLN GLN LEU VAL PHE SER PHE ASN ASP LYS LEU PHE
SEQRES 14 F 768 GLY LEU LEU VAL LYS ASP ILE GLU ALA MET ASP PRO SER
SEQRES 15 F 768 ILE LEU LYS GLY GLU PRO ALA SER GLY LYS ARG GLN LYS
SEQRES 16 F 768 ILE GLU VAL GLY LEU VAL VAL GLY ASN SER GLN VAL ALA
SEQRES 17 F 768 PHE GLU LYS ALA GLU ASN SER SER LEU ASN LEU ILE GLY
SEQRES 18 F 768 LYS ALA LYS THR LYS GLU ASN ARG GLN SER ILE ILE ASN
SEQRES 19 F 768 PRO ASP TRP ASN PHE GLU LYS MET GLY ILE GLY GLY LEU
SEQRES 20 F 768 ASP LYS GLU PHE SER ASP ILE PHE ARG ARG ALA PHE ALA
SEQRES 21 F 768 SER ARG VAL PHE PRO PRO GLU ILE VAL GLU GLN MET GLY
SEQRES 22 F 768 CYS LYS HIS VAL LYS GLY ILE LEU LEU TYR GLY PRO PRO
SEQRES 23 F 768 GLY CYS GLY LYS THR LEU LEU ALA ARG GLN ILE GLY LYS
SEQRES 24 F 768 MET LEU ASN ALA ARG GLU PRO LYS VAL VAL ASN GLY PRO
SEQRES 25 F 768 GLU ILE LEU ASN LYS TYR VAL GLY GLU SER GLU ALA ASN
SEQRES 26 F 768 ILE ARG LYS LEU PHE ALA ASP ALA GLU GLU GLU GLN ARG
SEQRES 27 F 768 ARG LEU GLY ALA ASN SER GLY LEU HIS ILE ILE ILE PHE
SEQRES 28 F 768 ASP GLU ILE ASP ALA ILE CYS LYS GLN ARG GLY SER MET
SEQRES 29 F 768 ALA GLY SER THR GLY VAL HIS ASP THR VAL VAL ASN GLN
SEQRES 30 F 768 LEU LEU SER LYS ILE ASP GLY VAL GLU GLN LEU ASN ASN
SEQRES 31 F 768 ILE LEU VAL ILE GLY MET THR ASN ARG PRO ASP LEU ILE
SEQRES 32 F 768 ASP GLU ALA LEU LEU ARG PRO GLY ARG LEU GLU VAL LYS
SEQRES 33 F 768 MET GLU ILE GLY LEU PRO ASP GLU LYS GLY ARG LEU GLN
SEQRES 34 F 768 ILE LEU HIS ILE HIS THR ALA ARG MET ARG GLY HIS GLN
SEQRES 35 F 768 LEU LEU SER ALA ASP VAL ASP ILE LYS GLU LEU ALA VAL
SEQRES 36 F 768 GLU THR LYS ASN PHE SER GLY ALA GLU LEU GLU GLY LEU
SEQRES 37 F 768 VAL ARG ALA ALA GLN SER THR ALA MET ASN ARG HIS ILE
SEQRES 38 F 768 ILE ALA SER THR LYS VAL GLU VAL ASP MET GLU LYS ALA
SEQRES 39 F 768 GLU SER LEU GLN VAL THR ARG GLY ASP PHE LEU ALA SER
SEQRES 40 F 768 LEU GLU ASN ASP ILE LYS PRO ALA PHE GLY THR ASN GLN
SEQRES 41 F 768 GLU ASP TYR ALA SER TYR ILE MET ASN GLY ILE ILE LYS
SEQRES 42 F 768 TRP GLY ASP PRO VAL THR ARG VAL LEU ASP ASP GLY GLU
SEQRES 43 F 768 LEU LEU VAL GLN GLN THR LYS ASN SER ASP ARG THR PRO
SEQRES 44 F 768 LEU VAL SER VAL LEU LEU GLU GLY PRO PRO HIS SER GLY
SEQRES 45 F 768 LYS THR ALA LEU ALA ALA LYS ILE ALA GLU GLU SER ASN
SEQRES 46 F 768 PHE PRO PHE ILE LYS ILE CYS SER PRO ASP LYS MET ILE
SEQRES 47 F 768 GLY PHE SER GLU THR ALA LYS CYS GLN ALA MET LYS LYS
SEQRES 48 F 768 ILE PHE ASP ASP ALA TYR LYS SER GLN LEU SER CYS VAL
SEQRES 49 F 768 VAL VAL ASP ASP ILE GLU ARG LEU LEU ASP TYR VAL PRO
SEQRES 50 F 768 ILE GLY PRO ARG PHE SER ASN LEU VAL LEU GLN ALA LEU
SEQRES 51 F 768 LEU VAL LEU LEU LYS LYS ALA PRO PRO GLN GLY ARG LYS
SEQRES 52 F 768 LEU LEU ILE ILE GLY THR THR SER ARG LYS ASP VAL LEU
SEQRES 53 F 768 GLN GLU MET GLU MET LEU ASN ALA PHE SER THR THR ILE
SEQRES 54 F 768 HIS VAL PRO ASN ILE ALA THR GLY GLU GLN LEU LEU GLU
SEQRES 55 F 768 ALA LEU GLU LEU LEU GLY ASN PHE LYS ASP LYS GLU ARG
SEQRES 56 F 768 THR THR ILE ALA GLN GLN VAL LYS GLY LYS LYS VAL TRP
SEQRES 57 F 768 ILE GLY ILE LYS LYS LEU LEU MET LEU ILE GLU MET SER
SEQRES 58 F 768 LEU GLN MET ASP PRO GLU TYR ARG VAL ARG LYS PHE LEU
SEQRES 59 F 768 ALA LEU LEU ARG GLU GLU GLY ALA SER PRO LEU ASP PHE
SEQRES 60 F 768 ASP
SEQRES 1 H 207 MET ALA SER MET ALA GLU ASP ALA ASP MET ARG ASN GLU
SEQRES 2 H 207 LEU GLU GLU MET GLN ARG ARG ALA ASP GLN LEU ALA ASP
SEQRES 3 H 207 GLU SER LEU GLU SER THR ARG ARG MET LEU GLN LEU VAL
SEQRES 4 H 207 GLU GLU SER LYS ASP ALA GLY ILE ARG THR LEU VAL MET
SEQRES 5 H 207 LEU ASP GLU GLN GLY GLU GLN LEU ASP ARG VAL GLU GLU
SEQRES 6 H 207 GLY MET ASN HIS ILE ASN GLN ASP MET LYS GLU ALA GLU
SEQRES 7 H 207 LYS ASN LEU LYS ASP LEU GLY LYS CYS CYS GLY LEU PHE
SEQRES 8 H 207 ILE CYS PRO CYS ASN LYS LEU LYS SER SER ASP ALA TYR
SEQRES 9 H 207 LYS LYS ALA TRP GLY ASN ASN GLN ASP GLY VAL VAL ALA
SEQRES 10 H 207 SER GLN PRO ALA ARG VAL VAL ASP GLU ARG GLU GLN MET
SEQRES 11 H 207 ALA ILE SER GLY GLY PHE ILE ARG ARG VAL THR ASN ASP
SEQRES 12 H 207 ALA ARG GLU ASN GLU MET ASP GLU ASN LEU GLU GLN VAL
SEQRES 13 H 207 SER GLY ILE ILE GLY ASN LEU ARG HIS MET ALA LEU ASP
SEQRES 14 H 207 MET GLY ASN GLU ILE ASP THR GLN ASN ARG GLN ILE ASP
SEQRES 15 H 207 ARG ILE MET GLU LYS ALA ASP SER ASN LYS THR ARG ILE
SEQRES 16 H 207 ASP GLU ALA ASN GLN ARG ALA THR LYS MET LEU GLY
SEQRES 1 I 256 MET LYS ASP ARG THR GLN GLU LEU ARG THR ALA LYS ASP
SEQRES 2 I 256 SER ASP ASP ASP ASP ASP VAL THR VAL THR VAL ASP ARG
SEQRES 3 I 256 ASP ARG PHE MET ASP GLU PHE PHE GLU GLN VAL GLU GLU
SEQRES 4 I 256 ILE ARG GLY PHE ILE ASP LYS ILE ALA GLU ASN VAL GLU
SEQRES 5 I 256 GLU VAL LYS ARG LYS HIS SER ALA ILE LEU ALA SER PRO
SEQRES 6 I 256 ASN PRO ASP GLU LYS THR LYS GLU GLU LEU GLU GLU LEU
SEQRES 7 I 256 MET SER ASP ILE LYS LYS THR ALA ASN LYS VAL ARG SER
SEQRES 8 I 256 LYS LEU LYS SER ILE GLU GLN SER ILE GLU GLN GLU GLU
SEQRES 9 I 256 GLY LEU ASN ARG SER SER ALA ASP LEU ARG ILE ARG LYS
SEQRES 10 I 256 THR GLN HIS SER THR LEU SER ARG LYS PHE VAL GLU VAL
SEQRES 11 I 256 MET SER GLU TYR ASN ALA THR GLN SER ASP TYR ARG GLU
SEQRES 12 I 256 ARG SER LYS GLY ARG ILE GLN ARG GLN LEU GLU ILE THR
SEQRES 13 I 256 GLY ARG THR THR THR SER GLU GLU LEU GLU ASP MET LEU
SEQRES 14 I 256 GLU SER GLY ASN PRO ALA ILE PHE ALA SER GLY ILE ILE
SEQRES 15 I 256 MET ASP SER SER ILE SER LYS GLN ALA LEU SER GLU ILE
SEQRES 16 I 256 GLU THR ARG HIS SER GLU ILE ILE LYS LEU GLU ASN SER
SEQRES 17 I 256 ILE ARG GLU LEU HIS ASP MET PHE MET ASP MET ALA MET
SEQRES 18 I 256 LEU VAL GLU SER GLN GLY GLU MET ILE ASP ARG ILE GLU
SEQRES 19 I 256 TYR ASN VAL GLU HIS ALA VAL ASP TYR VAL GLU ARG ALA
SEQRES 20 I 256 VAL SER ASP THR LYS LYS ALA VAL LYS
SEQRES 1 J 117 MET ALA SER TYR TYR HIS HIS HIS HIS HIS HIS ASP TYR
SEQRES 2 J 117 ASP ILE PRO THR SER GLU ASN LEU TYR PHE GLN GLY ALA
SEQRES 3 J 117 SER HIS MET SER ALA THR ALA ALA THR VAL PRO PRO ALA
SEQRES 4 J 117 ALA PRO ALA GLY GLU GLY GLY PRO PRO ALA PRO PRO PRO
SEQRES 5 J 117 ASN LEU THR SER ASN ARG ARG LEU GLN GLN THR GLN ALA
SEQRES 6 J 117 GLN VAL ASP GLU VAL VAL ASP ILE MET ARG VAL ASN VAL
SEQRES 7 J 117 ASP LYS VAL LEU GLU ARG ASP GLN LYS LEU SER GLU LEU
SEQRES 8 J 117 ASP ASP ARG ALA ASP ALA LEU GLN ALA GLY ALA SER GLN
SEQRES 9 J 117 PHE GLU THR SER ALA ALA LYS LEU LYS ARG LYS TYR TRP
SEQRES 1 K 313 MET HIS HIS HIS HIS HIS HIS HIS HIS HIS HIS GLU ASN
SEQRES 2 K 313 LEU TYR PHE GLN GLY MET ASP THR SER GLY LYS GLN ALA
SEQRES 3 K 313 GLU ALA MET ALA LEU LEU ALA GLU ALA GLU ARG LYS VAL
SEQRES 4 K 313 LYS ASN SER GLN SER PHE PHE SER GLY LEU PHE GLY GLY
SEQRES 5 K 313 SER SER LYS ILE GLU GLU ALA CYS GLU ILE TYR ALA ARG
SEQRES 6 K 313 ALA ALA ASN MET PHE LYS MET ALA LYS ASN TRP SER ALA
SEQRES 7 K 313 ALA GLY ASN ALA PHE CYS GLN ALA ALA GLN LEU HIS LEU
SEQRES 8 K 313 GLN LEU GLN SER LYS HIS ASP ALA ALA THR CYS PHE VAL
SEQRES 9 K 313 ASP ALA GLY ASN ALA PHE LYS LYS ALA ASP PRO GLN GLU
SEQRES 10 K 313 ALA ILE ASN CYS LEU MET ARG ALA ILE GLU ILE TYR THR
SEQRES 11 K 313 ASP MET GLY ARG PHE THR ILE ALA ALA LYS HIS HIS ILE
SEQRES 12 K 313 SER ILE ALA GLU ILE TYR GLU THR GLU LEU VAL ASP VAL
SEQRES 13 K 313 GLU LYS ALA ILE ALA HIS TYR GLU GLN SER ALA ASP TYR
SEQRES 14 K 313 TYR LYS GLY GLU GLU SER ASN SER SER ALA ASN LYS CYS
SEQRES 15 K 313 LEU LEU LYS VAL ALA GLY TYR ALA ALA GLN LEU GLU GLN
SEQRES 16 K 313 TYR GLN LYS ALA ILE ASP ILE TYR GLU GLN VAL GLY THR
SEQRES 17 K 313 SER ALA MET ASP SER PRO LEU LEU LYS TYR SER ALA LYS
SEQRES 18 K 313 ASP TYR PHE PHE LYS ALA ALA LEU CYS HIS PHE CYS ILE
SEQRES 19 K 313 ASP MET LEU ASN ALA LYS LEU ALA VAL GLN LYS TYR GLU
SEQRES 20 K 313 GLU LEU PHE PRO ALA PHE SER ASP SER ARG GLU CYS LYS
SEQRES 21 K 313 LEU MET LYS LYS LEU LEU GLU ALA HIS GLU GLU GLN ASN
SEQRES 22 K 313 VAL ASP SER TYR THR GLU SER VAL LYS GLU TYR ASP SER
SEQRES 23 K 313 ILE SER ARG LEU ASP GLN TRP LEU THR THR MET LEU LEU
SEQRES 24 K 313 ARG ILE LYS LYS THR ILE GLN GLY ASP GLU GLU ASP LEU
SEQRES 25 K 313 ARG
SEQRES 1 L 313 MET HIS HIS HIS HIS HIS HIS HIS HIS HIS HIS GLU ASN
SEQRES 2 L 313 LEU TYR PHE GLN GLY MET ASP THR SER GLY LYS GLN ALA
SEQRES 3 L 313 GLU ALA MET ALA LEU LEU ALA GLU ALA GLU ARG LYS VAL
SEQRES 4 L 313 LYS ASN SER GLN SER PHE PHE SER GLY LEU PHE GLY GLY
SEQRES 5 L 313 SER SER LYS ILE GLU GLU ALA CYS GLU ILE TYR ALA ARG
SEQRES 6 L 313 ALA ALA ASN MET PHE LYS MET ALA LYS ASN TRP SER ALA
SEQRES 7 L 313 ALA GLY ASN ALA PHE CYS GLN ALA ALA GLN LEU HIS LEU
SEQRES 8 L 313 GLN LEU GLN SER LYS HIS ASP ALA ALA THR CYS PHE VAL
SEQRES 9 L 313 ASP ALA GLY ASN ALA PHE LYS LYS ALA ASP PRO GLN GLU
SEQRES 10 L 313 ALA ILE ASN CYS LEU MET ARG ALA ILE GLU ILE TYR THR
SEQRES 11 L 313 ASP MET GLY ARG PHE THR ILE ALA ALA LYS HIS HIS ILE
SEQRES 12 L 313 SER ILE ALA GLU ILE TYR GLU THR GLU LEU VAL ASP VAL
SEQRES 13 L 313 GLU LYS ALA ILE ALA HIS TYR GLU GLN SER ALA ASP TYR
SEQRES 14 L 313 TYR LYS GLY GLU GLU SER ASN SER SER ALA ASN LYS CYS
SEQRES 15 L 313 LEU LEU LYS VAL ALA GLY TYR ALA ALA GLN LEU GLU GLN
SEQRES 16 L 313 TYR GLN LYS ALA ILE ASP ILE TYR GLU GLN VAL GLY THR
SEQRES 17 L 313 SER ALA MET ASP SER PRO LEU LEU LYS TYR SER ALA LYS
SEQRES 18 L 313 ASP TYR PHE PHE LYS ALA ALA LEU CYS HIS PHE CYS ILE
SEQRES 19 L 313 ASP MET LEU ASN ALA LYS LEU ALA VAL GLN LYS TYR GLU
SEQRES 20 L 313 GLU LEU PHE PRO ALA PHE SER ASP SER ARG GLU CYS LYS
SEQRES 21 L 313 LEU MET LYS LYS LEU LEU GLU ALA HIS GLU GLU GLN ASN
SEQRES 22 L 313 VAL ASP SER TYR THR GLU SER VAL LYS GLU TYR ASP SER
SEQRES 23 L 313 ILE SER ARG LEU ASP GLN TRP LEU THR THR MET LEU LEU
SEQRES 24 L 313 ARG ILE LYS LYS THR ILE GLN GLY ASP GLU GLU ASP LEU
SEQRES 25 L 313 ARG
HET ATP A 801 43
HET ADP A 802 39
HET ATP B 801 43
HET ATP B 802 43
HET ATP C 801 43
HET ATP C 802 43
HET ATP D 801 43
HET ATP D 802 43
HET ATP E 801 43
HET ADP E 802 39
HET ATP F 801 43
HETNAM ATP ADENOSINE-5'-TRIPHOSPHATE
HETNAM ADP ADENOSINE-5'-DIPHOSPHATE
FORMUL 12 ATP 9(C10 H16 N5 O13 P3)
FORMUL 13 ADP 2(C10 H15 N5 O10 P2)
HELIX 1 AA1 THR A 13 LEU A 18 5 6
HELIX 2 AA2 SER A 63 GLY A 71 1 9
HELIX 3 AA3 THR A 114 PHE A 125 1 12
HELIX 4 AA4 LEU A 223 ALA A 234 1 12
HELIX 5 AA5 PRO A 241 GLY A 249 1 9
HELIX 6 AA6 LYS A 266 LEU A 277 1 12
HELIX 7 AA7 GLY A 296 GLY A 317 1 22
HELIX 8 AA8 THR A 349 GLY A 360 1 12
HELIX 9 AA9 ASP A 399 GLN A 418 1 20
HELIX 10 AB1 ASP A 425 GLU A 432 1 8
HELIX 11 AB2 SER A 437 HIS A 456 1 20
HELIX 12 AB3 LEU A 481 ASN A 486 1 6
HELIX 13 AB4 ASP A 498 ILE A 503 1 6
HELIX 14 AB5 GLY A 511 ASN A 530 1 20
HELIX 15 AB6 GLY A 548 SER A 560 1 13
HELIX 16 AB7 SER A 569 ILE A 574 1 6
HELIX 17 AB8 SER A 577 LYS A 594 1 18
HELIX 18 AB9 ASP A 604 LEU A 609 1 6
HELIX 19 AC1 SER A 619 LYS A 632 1 14
HELIX 20 AC2 LYS A 649 MET A 655 1 7
HELIX 21 AC3 THR A 672 GLY A 684 1 13
HELIX 22 AC4 LYS A 687 VAL A 698 1 12
HELIX 23 AC5 GLY A 706 GLN A 719 1 14
HELIX 24 AC6 ASP A 721 ARG A 734 1 14
HELIX 25 AC7 GLU B 15 SER B 19 5 5
HELIX 26 AC8 SER B 63 LYS B 68 1 6
HELIX 27 AC9 ASP B 86 CYS B 91 1 6
HELIX 28 AD1 THR B 114 PHE B 125 1 12
HELIX 29 AD2 LEU B 223 PHE B 240 1 18
HELIX 30 AD3 PRO B 241 GLY B 249 1 9
HELIX 31 AD4 LYS B 266 LEU B 277 1 12
HELIX 32 AD5 GLY B 296 LEU B 316 1 21
HELIX 33 AD6 GLU B 329 CYS B 334 1 6
HELIX 34 AD7 ASP B 348 ASP B 359 1 12
HELIX 35 AD8 ARG B 375 ILE B 379 5 5
HELIX 36 AD9 ASP B 380 ARG B 385 1 6
HELIX 37 AE1 ASP B 399 HIS B 417 1 19
HELIX 38 AE2 ASP B 425 THR B 433 1 9
HELIX 39 AE3 ALA B 439 ARG B 455 1 17
HELIX 40 AE4 LEU B 481 ASN B 486 1 6
HELIX 41 AE5 ASP B 498 TYR B 502 5 5
HELIX 42 AE6 GLY B 511 ASN B 530 1 20
HELIX 43 AE7 GLY B 548 SER B 560 1 13
HELIX 44 AE8 SER B 577 TYR B 593 1 17
HELIX 45 AE9 ASP B 604 LEU B 609 1 6
HELIX 46 AF1 SER B 619 LEU B 630 1 12
HELIX 47 AF2 LYS B 649 MET B 655 1 7
HELIX 48 AF3 GLY B 673 GLY B 684 1 12
HELIX 49 AF4 ASP B 688 VAL B 698 1 11
HELIX 50 AF5 GLY B 706 GLN B 719 1 14
HELIX 51 AF6 ASP B 721 GLU B 735 1 15
HELIX 52 AF7 GLU C 15 SER C 19 5 5
HELIX 53 AF8 SER C 63 GLY C 71 1 9
HELIX 54 AF9 ASP C 86 CYS C 91 1 6
HELIX 55 AG1 GLN C 103 ILE C 107 5 5
HELIX 56 AG2 THR C 114 PHE C 125 1 12
HELIX 57 AG3 GLY C 197 THR C 201 5 5
HELIX 58 AG4 LEU C 223 ALA C 236 1 14
HELIX 59 AG5 PRO C 241 GLY C 249 1 9
HELIX 60 AG6 GLY C 265 MET C 276 1 12
HELIX 61 AG7 GLY C 296 GLY C 317 1 22
HELIX 62 AG8 HIS C 347 ASP C 359 1 13
HELIX 63 AG9 ARG C 375 ILE C 379 5 5
HELIX 64 AH1 ASP C 380 ARG C 385 1 6
HELIX 65 AH2 ASP C 399 HIS C 417 1 19
HELIX 66 AH3 ASP C 425 THR C 433 1 9
HELIX 67 AH4 GLY C 438 ILE C 457 1 20
HELIX 68 AH5 PHE C 480 ASN C 486 1 7
HELIX 69 AH6 GLU C 497 ILE C 503 1 7
HELIX 70 AH7 GLY C 511 SER C 531 1 21
HELIX 71 AH8 LYS C 549 ASN C 561 1 13
HELIX 72 AH9 SER C 577 TYR C 593 1 17
HELIX 73 AI1 ASP C 604 LEU C 609 1 6
HELIX 74 AI2 SER C 619 LYS C 632 1 14
HELIX 75 AI3 LYS C 649 MET C 655 1 7
HELIX 76 AI4 THR C 672 GLY C 684 1 13
HELIX 77 AI5 GLU C 690 LYS C 699 1 10
HELIX 78 AI6 GLY C 706 GLN C 719 1 14
HELIX 79 AI7 ASP C 721 ALA C 738 1 18
HELIX 80 AI8 ASP D 14 SER D 19 5 6
HELIX 81 AI9 SER D 63 GLY D 71 1 9
HELIX 82 AJ1 THR D 114 PHE D 125 1 12
HELIX 83 AJ2 LEU D 223 PHE D 235 1 13
HELIX 84 AJ3 PHE D 235 PHE D 240 1 6
HELIX 85 AJ4 PRO D 242 MET D 248 1 7
HELIX 86 AJ5 GLY D 265 MET D 276 1 12
HELIX 87 AJ6 SER D 298 LEU D 316 1 19
HELIX 88 AJ7 GLU D 329 CYS D 334 1 6
HELIX 89 AJ8 GLY D 345 ASP D 348 5 4
HELIX 90 AJ9 THR D 349 ASP D 359 1 11
HELIX 91 AK1 ASP D 380 LEU D 384 5 5
HELIX 92 AK2 LYS D 401 HIS D 417 1 17
HELIX 93 AK3 ASP D 425 THR D 433 1 9
HELIX 94 AK4 GLY D 438 ILE D 458 1 21
HELIX 95 AK5 LEU D 481 LYS D 489 1 9
HELIX 96 AK6 GLY D 511 SER D 531 1 21
HELIX 97 AK7 GLY D 548 ASN D 561 1 14
HELIX 98 AK8 SER D 577 LYS D 594 1 18
HELIX 99 AK9 ASP D 604 LEU D 609 1 6
HELIX 100 AL1 SER D 619 LYS D 631 1 13
HELIX 101 AL2 VAL D 651 MET D 655 5 5
HELIX 102 AL3 THR D 672 GLY D 684 1 13
HELIX 103 AL4 LYS D 687 LYS D 699 1 13
HELIX 104 AL5 GLY D 706 GLN D 719 1 14
HELIX 105 AL6 ASP D 721 GLY D 737 1 17
HELIX 106 AL7 GLU E 216 ILE E 220 5 5
HELIX 107 AL8 LEU E 223 ALA E 236 1 14
HELIX 108 AL9 GLY E 265 LEU E 277 1 13
HELIX 109 AM1 ASN E 286 LEU E 291 5 6
HELIX 110 AM2 GLY E 296 GLY E 317 1 22
HELIX 111 AM3 GLU E 329 CYS E 334 1 6
HELIX 112 AM4 VAL E 351 GLY E 360 1 10
HELIX 113 AM5 PRO E 376 LEU E 384 1 9
HELIX 114 AM6 ASP E 399 GLY E 416 1 18
HELIX 115 AM7 ASP E 425 THR E 433 1 9
HELIX 116 AM8 GLY E 438 ARG E 455 1 18
HELIX 117 AM9 ASP E 479 LYS E 489 1 11
HELIX 118 AN1 GLY E 511 SER E 531 1 21
HELIX 119 AN2 LYS E 549 ASN E 561 1 13
HELIX 120 AN3 SER E 569 ILE E 574 5 6
HELIX 121 AN4 SER E 577 SER E 595 1 19
HELIX 122 AN5 ASP E 604 LEU E 609 1 6
HELIX 123 AN6 SER E 619 LYS E 632 1 14
HELIX 124 AN7 LYS E 649 MET E 655 1 7
HELIX 125 AN8 THR E 672 GLY E 684 1 13
HELIX 126 AN9 LYS E 687 LYS E 699 1 13
HELIX 127 AO1 GLY E 706 GLN E 719 1 14
HELIX 128 AO2 ARG E 725 ARG E 734 1 10
HELIX 129 AO3 ASP F 224 VAL F 239 1 16
HELIX 130 AO4 GLY F 265 ASN F 278 1 14
HELIX 131 AO5 GLU F 299 LEU F 316 1 18
HELIX 132 AO6 ASP F 348 ASP F 359 1 12
HELIX 133 AO7 ASP F 399 THR F 411 1 13
HELIX 134 AO8 LYS F 427 GLU F 432 1 6
HELIX 135 AO9 THR F 433 PHE F 436 5 4
HELIX 136 AP1 GLY F 443 ASN F 454 1 12
HELIX 137 AP2 TYR F 499 ILE F 503 5 5
HELIX 138 AP3 GLY F 511 ASN F 530 1 20
HELIX 139 AP4 LYS F 549 SER F 560 1 12
HELIX 140 AP5 SER F 577 SER F 595 1 19
HELIX 141 AP6 ASP F 604 LEU F 609 1 6
HELIX 142 AP7 SER F 619 LYS F 632 1 14
HELIX 143 AP8 LYS F 649 MET F 655 1 7
HELIX 144 AP9 THR F 672 GLY F 684 1 13
HELIX 145 AQ1 LYS F 687 GLN F 696 1 10
HELIX 146 AQ2 GLY F 706 MET F 720 1 15
HELIX 147 AQ3 TYR F 724 GLU F 736 1 13
HELIX 148 AQ4 ASP H 19 ALA H 22 5 4
HELIX 149 AQ5 ASP H 23 LEU H 35 1 13
HELIX 150 AQ6 VAL H 36 LYS H 72 1 37
HELIX 151 AQ7 GLU H 73 LYS H 83 1 11
HELIX 152 AQ8 ARG H 142 LYS H 201 1 60
HELIX 153 AQ9 LEU I 192 VAL I 237 1 46
HELIX 154 AR1 GLU I 238 LYS I 252 1 15
HELIX 155 AR2 ARG J 30 ARG J 86 1 57
HELIX 156 AR3 MET K 11 ARG K 19 1 9
HELIX 157 AR4 GLY K 34 ALA K 55 1 22
HELIX 158 AR5 ASN K 57 HIS K 72 1 16
HELIX 159 AR6 LEU K 73 LEU K 75 5 3
HELIX 160 AR7 ASP K 80 ALA K 95 1 16
HELIX 161 AR8 GLU K 99 MET K 114 1 16
HELIX 162 AR9 PHE K 117 GLU K 134 1 18
HELIX 163 AS1 ASP K 137 GLY K 154 1 18
HELIX 164 AS2 SER K 157 GLU K 176 1 20
HELIX 165 AS3 TYR K 178 SER K 195 1 18
HELIX 166 AS4 SER K 201 CYS K 212 1 12
HELIX 167 AS5 LEU K 219 GLN K 226 1 8
HELIX 168 AS6 ALA K 234 SER K 238 5 5
HELIX 169 AS7 CYS K 241 GLU K 253 1 13
HELIX 170 AS8 SER K 258 SER K 270 1 13
HELIX 171 AS9 ASP K 273 GLU K 291 1 19
HELIX 172 AT1 ALA L 10 VAL L 21 1 12
HELIX 173 AT2 GLY L 34 ALA L 55 1 22
HELIX 174 AT3 ALA L 60 GLN L 74 1 15
HELIX 175 AT4 LYS L 78 LYS L 93 1 16
HELIX 176 AT5 GLN L 98 GLY L 115 1 18
HELIX 177 AT6 ARG L 116 GLU L 134 1 19
HELIX 178 AT7 ASP L 137 GLU L 155 1 19
HELIX 179 AT8 SER L 157 GLY L 170 1 14
HELIX 180 AT9 TYR L 171 ALA L 173 5 3
HELIX 181 AU1 GLN L 177 THR L 190 1 14
HELIX 182 AU2 LEU L 198 ALA L 209 1 12
HELIX 183 AU3 LEU L 223 TYR L 228 1 6
HELIX 184 AU4 GLU L 240 GLN L 254 1 15
HELIX 185 AU5 ASN L 255 SER L 270 1 16
HELIX 186 AU6 ASP L 273 GLU L 292 1 20
SHEET 1 AA1 7 ARG A 4 ARG A 10 0
SHEET 2 AA1 7 VAL A 60 PHE A 62 1 O VAL A 60 N ALA A 9
SHEET 3 AA1 7 ALA A 22 VAL A 24 -1 N VAL A 23 O ALA A 61
SHEET 4 AA1 7 LYS A 44 THR A 51 1 O THR A 48 N ALA A 22
SHEET 5 AA1 7 HIS A 34 ARG A 38 -1 N VAL A 35 O PHE A 47
SHEET 6 AA1 7 GLU A 77 LEU A 82 -1 O ALA A 81 N ILE A 36
SHEET 7 AA1 7 ARG A 4 ARG A 10 -1 N MET A 6 O ILE A 78
SHEET 1 AA2 3 ASP A 100 PHE A 101 0
SHEET 2 AA2 3 LYS A 143 ALA A 154 -1 O GLY A 146 N ASP A 100
SHEET 3 AA2 3 SER A 139 PHE A 140 -1 N PHE A 140 O LYS A 143
SHEET 1 AA3 4 GLN A 135 LEU A 136 0
SHEET 2 AA3 4 LYS A 143 ALA A 154 -1 O LEU A 147 N LEU A 136
SHEET 3 AA3 4 ILE A 92 ILE A 97 -1 N GLY A 93 O GLU A 153
SHEET 4 AA3 4 GLN A 182 PHE A 185 1 O ALA A 184 N MET A 95
SHEET 1 AA4 2 PRO A 111 ASP A 113 0
SHEET 2 AA4 2 ASN A 194 ILE A 196 1 O ILE A 196 N TYR A 112
SHEET 1 AA5 2 GLN A 128 SER A 131 0
SHEET 2 AA5 2 VAL A 174 VAL A 177 -1 O GLY A 175 N PHE A 130
SHEET 1 AA6 5 ALA A 279 VAL A 285 0
SHEET 2 AA6 5 LEU A 322 PHE A 327 1 O ILE A 326 N VAL A 285
SHEET 3 AA6 5 ILE A 367 THR A 373 1 O LEU A 368 N ILE A 325
SHEET 4 AA6 5 GLY A 255 TYR A 259 1 N ILE A 256 O GLY A 371
SHEET 5 AA6 5 VAL A 391 GLU A 394 1 O MET A 393 N TYR A 259
SHEET 1 AA7 5 PHE A 564 CYS A 568 0
SHEET 2 AA7 5 LEU A 597 VAL A 602 1 O VAL A 601 N LYS A 566
SHEET 3 AA7 5 LYS A 639 GLY A 644 1 O ILE A 643 N VAL A 602
SHEET 4 AA7 5 LEU A 536 GLU A 542 1 N LEU A 541 O GLY A 644
SHEET 5 AA7 5 THR A 663 HIS A 666 1 O ILE A 665 N GLU A 542
SHEET 1 AA8 7 ARG B 4 ARG B 10 0
SHEET 2 AA8 7 VAL B 60 PHE B 62 1 O VAL B 60 N GLN B 7
SHEET 3 AA8 7 CYS B 21 VAL B 24 -1 N VAL B 23 O ALA B 61
SHEET 4 AA8 7 HIS B 43 THR B 51 1 O THR B 48 N ALA B 22
SHEET 5 AA8 7 HIS B 34 SER B 40 -1 N VAL B 35 O PHE B 47
SHEET 6 AA8 7 GLU B 77 TYR B 83 -1 O ALA B 81 N ILE B 36
SHEET 7 AA8 7 ARG B 4 ARG B 10 -1 N MET B 6 O ILE B 78
SHEET 1 AA9 3 GLN B 135 PHE B 140 0
SHEET 2 AA9 3 LYS B 143 GLU B 153 -1 O LEU B 147 N LEU B 136
SHEET 3 AA9 3 LYS B 171 ILE B 172 -1 O ILE B 172 N ILE B 152
SHEET 1 AB1 4 GLN B 135 PHE B 140 0
SHEET 2 AB1 4 LYS B 143 GLU B 153 -1 O LEU B 147 N LEU B 136
SHEET 3 AB1 4 THR B 94 ASP B 100 -1 N ASP B 100 O GLY B 146
SHEET 4 AB1 4 GLN B 182 LYS B 187 1 O ALA B 184 N MET B 95
SHEET 1 AB2 2 TYR B 112 ASP B 113 0
SHEET 2 AB2 2 LEU B 195 ILE B 196 1 O ILE B 196 N TYR B 112
SHEET 1 AB3 2 GLN B 128 SER B 131 0
SHEET 2 AB3 2 VAL B 174 VAL B 177 -1 O GLY B 175 N PHE B 130
SHEET 1 AB4 5 LYS B 283 VAL B 285 0
SHEET 2 AB4 5 ILE B 325 PHE B 327 1 O ILE B 326 N VAL B 285
SHEET 3 AB4 5 VAL B 369 THR B 373 1 O ILE B 370 N ILE B 325
SHEET 4 AB4 5 GLY B 255 TYR B 259 1 N LEU B 258 O GLY B 371
SHEET 5 AB4 5 LYS B 392 GLU B 394 1 O MET B 393 N TYR B 259
SHEET 1 AB5 5 PHE B 564 CYS B 568 0
SHEET 2 AB5 5 LEU B 597 VAL B 602 1 O CYS B 599 N PHE B 564
SHEET 3 AB5 5 LYS B 639 THR B 646 1 O LEU B 641 N SER B 598
SHEET 4 AB5 5 VAL B 539 GLU B 542 1 N LEU B 541 O THR B 646
SHEET 5 AB5 5 THR B 663 HIS B 666 1 O ILE B 665 N GLU B 542
SHEET 1 AB6 2 ILE B 670 THR B 672 0
SHEET 2 AB6 2 LYS B 702 ILE B 705 -1 O VAL B 703 N ALA B 671
SHEET 1 AB7 7 ARG C 4 ARG C 10 0
SHEET 2 AB7 7 VAL C 60 PHE C 62 1 O VAL C 60 N ALA C 9
SHEET 3 AB7 7 ALA C 22 VAL C 24 -1 N VAL C 23 O ALA C 61
SHEET 4 AB7 7 HIS C 43 THR C 51 1 O THR C 48 N ALA C 22
SHEET 5 AB7 7 HIS C 34 SER C 40 -1 N VAL C 37 O TYR C 45
SHEET 6 AB7 7 GLU C 77 LEU C 82 -1 O GLU C 79 N ARG C 38
SHEET 7 AB7 7 ARG C 4 ARG C 10 -1 N MET C 6 O ILE C 78
SHEET 1 AB8 3 GLN C 135 SER C 139 0
SHEET 2 AB8 3 LEU C 144 ALA C 154 -1 O LEU C 147 N LEU C 136
SHEET 3 AB8 3 GLN C 170 ILE C 172 -1 O GLN C 170 N ALA C 154
SHEET 1 AB9 4 GLN C 135 SER C 139 0
SHEET 2 AB9 4 LEU C 144 ALA C 154 -1 O LEU C 147 N LEU C 136
SHEET 3 AB9 4 THR C 94 ILE C 99 -1 N GLU C 98 O LEU C 148
SHEET 4 AB9 4 GLN C 182 LYS C 187 1 O ALA C 184 N MET C 95
SHEET 1 AC1 2 PRO C 111 ASP C 113 0
SHEET 2 AC1 2 ASN C 194 ILE C 196 1 O ILE C 196 N TYR C 112
SHEET 1 AC2 2 ALA C 129 SER C 131 0
SHEET 2 AC2 2 VAL C 174 LEU C 176 -1 O GLY C 175 N PHE C 130
SHEET 1 AC3 5 LYS C 283 VAL C 284 0
SHEET 2 AC3 5 HIS C 323 ILE C 326 1 O ILE C 324 N LYS C 283
SHEET 3 AC3 5 ILE C 367 THR C 373 1 O ILE C 370 N ILE C 325
SHEET 4 AC3 5 LEU C 257 TYR C 259 1 N LEU C 258 O GLY C 371
SHEET 5 AC3 5 LYS C 392 GLU C 394 1 O MET C 393 N TYR C 259
SHEET 1 AC4 4 LEU C 597 VAL C 601 0
SHEET 2 AC4 4 LYS C 639 THR C 646 1 O ILE C 643 N VAL C 600
SHEET 3 AC4 4 LEU C 536 GLU C 542 1 N LEU C 541 O GLY C 644
SHEET 4 AC4 4 THR C 663 HIS C 666 1 O ILE C 665 N GLU C 542
SHEET 1 AC5 7 ARG D 4 ARG D 10 0
SHEET 2 AC5 7 VAL D 60 PHE D 62 1 O VAL D 60 N GLN D 7
SHEET 3 AC5 7 CYS D 21 VAL D 24 -1 N VAL D 23 O ALA D 61
SHEET 4 AC5 7 LYS D 44 THR D 51 1 O THR D 48 N ALA D 22
SHEET 5 AC5 7 HIS D 34 ARG D 38 -1 N VAL D 37 O TYR D 45
SHEET 6 AC5 7 GLU D 77 LEU D 82 -1 O ALA D 81 N ILE D 36
SHEET 7 AC5 7 ARG D 4 ARG D 10 -1 N MET D 6 O ILE D 78
SHEET 1 AC6 3 GLN D 135 LEU D 136 0
SHEET 2 AC6 3 GLY D 146 ALA D 154 -1 O LEU D 147 N LEU D 136
SHEET 3 AC6 3 GLN D 170 LYS D 171 -1 O GLN D 170 N ALA D 154
SHEET 1 AC7 4 GLN D 135 LEU D 136 0
SHEET 2 AC7 4 GLY D 146 ALA D 154 -1 O LEU D 147 N LEU D 136
SHEET 3 AC7 4 ILE D 92 ASP D 100 -1 N GLU D 98 O LEU D 148
SHEET 4 AC7 4 GLN D 182 LYS D 187 1 O ALA D 184 N MET D 95
SHEET 1 AC8 2 PRO D 111 ASP D 113 0
SHEET 2 AC8 2 ASN D 194 ILE D 196 1 O ASN D 194 N TYR D 112
SHEET 1 AC9 2 ALA D 129 SER D 131 0
SHEET 2 AC9 2 VAL D 174 LEU D 176 -1 O GLY D 175 N PHE D 130
SHEET 1 AD1 2 SER D 139 PHE D 140 0
SHEET 2 AD1 2 LYS D 143 LEU D 144 -1 O LYS D 143 N PHE D 140
SHEET 1 AD2 5 LYS D 283 VAL D 284 0
SHEET 2 AD2 5 HIS D 323 ILE D 326 1 O ILE D 324 N LYS D 283
SHEET 3 AD2 5 ILE D 367 THR D 373 1 O LEU D 368 N ILE D 325
SHEET 4 AD2 5 GLY D 255 TYR D 259 1 N ILE D 256 O VAL D 369
SHEET 5 AD2 5 LYS D 392 GLU D 394 1 O MET D 393 N TYR D 259
SHEET 1 AD3 5 ILE D 565 CYS D 568 0
SHEET 2 AD3 5 LEU D 597 VAL D 602 1 O VAL D 601 N CYS D 568
SHEET 3 AD3 5 LYS D 639 THR D 646 1 O ILE D 643 N VAL D 600
SHEET 4 AD3 5 LEU D 536 GLU D 542 1 N LEU D 541 O GLY D 644
SHEET 5 AD3 5 THR D 663 HIS D 666 1 O ILE D 665 N GLU D 542
SHEET 1 AD4 2 LEU E 258 TYR E 259 0
SHEET 2 AD4 2 MET E 393 GLU E 394 1 O MET E 393 N TYR E 259
SHEET 1 AD5 3 LYS E 283 VAL E 285 0
SHEET 2 AD5 3 ILE E 324 ASP E 328 1 O ILE E 326 N LYS E 283
SHEET 3 AD5 3 LEU E 368 MET E 372 1 O LEU E 368 N ILE E 325
SHEET 1 AD6 4 LEU E 540 GLU E 542 0
SHEET 2 AD6 4 LEU E 641 THR E 646 1 O GLY E 644 N LEU E 541
SHEET 3 AD6 4 SER E 598 VAL E 602 1 N VAL E 602 O ILE E 643
SHEET 4 AD6 4 PHE E 564 CYS E 568 1 N CYS E 568 O VAL E 601
SHEET 1 AD7 4 LEU F 258 TYR F 259 0
SHEET 2 AD7 4 LEU F 368 THR F 373 1 O THR F 373 N LEU F 258
SHEET 3 AD7 4 ILE F 324 ASP F 328 1 N PHE F 327 O ILE F 370
SHEET 4 AD7 4 VAL F 285 ASN F 286 1 N ASN F 286 O ASP F 328
SHEET 1 AD8 5 PHE F 564 CYS F 568 0
SHEET 2 AD8 5 SER F 598 VAL F 602 1 O VAL F 601 N CYS F 568
SHEET 3 AD8 5 LEU F 640 THR F 646 1 O ILE F 643 N VAL F 602
SHEET 4 AD8 5 LEU F 536 GLU F 542 1 N VAL F 537 O ILE F 642
SHEET 5 AD8 5 SER F 662 HIS F 666 1 O ILE F 665 N GLU F 542
SITE 1 AC1 13 ASN A 505 GLY A 506 ILE A 507 ILE A 508
SITE 2 AC1 13 TRP A 510 VAL A 514 PRO A 545 HIS A 546
SITE 3 AC1 13 GLY A 548 THR A 550 ASP A 604 ILE A 707
SITE 4 AC1 13 LYS A 708
SITE 1 AC2 10 GLY A 221 PRO A 262 CYS A 264 GLY A 265
SITE 2 AC2 10 THR A 267 LEU A 268 MET A 372 ILE A 406
SITE 3 AC2 10 GLY A 438 GLU A 442
SITE 1 AC3 18 LEU A 355 ASP A 359 ARG A 385 ARG A 388
SITE 2 AC3 18 ILE B 220 GLY B 221 PRO B 261 PRO B 262
SITE 3 AC3 18 CYS B 264 GLY B 265 LYS B 266 THR B 267
SITE 4 AC3 18 LEU B 268 ASN B 374 ILE B 406 HIS B 410
SITE 5 AC3 18 GLY B 438 GLU B 442
SITE 1 AC4 12 LYS A 631 ASN B 505 GLY B 506 ILE B 507
SITE 2 AC4 12 ILE B 508 PRO B 545 GLY B 548 LYS B 549
SITE 3 AC4 12 THR B 550 ALA B 551 ASP B 604 LYS B 708
SITE 1 AC5 17 LYS B 631 TYR C 502 MET C 504 ASN C 505
SITE 2 AC5 17 GLY C 506 ILE C 507 ILE C 508 TRP C 510
SITE 3 AC5 17 PRO C 545 HIS C 546 SER C 547 GLY C 548
SITE 4 AC5 17 LYS C 549 THR C 550 LEU C 552 ILE C 707
SITE 5 AC5 17 LYS C 708
SITE 1 AC6 18 ASP B 359 ARG B 385 ARG B 388 GLY C 219
SITE 2 AC6 18 ILE C 220 GLY C 221 PRO C 261 PRO C 262
SITE 3 AC6 18 GLY C 263 CYS C 264 GLY C 265 LYS C 266
SITE 4 AC6 18 THR C 267 LEU C 268 GLU C 329 ILE C 406
SITE 5 AC6 18 ALA C 439 GLU C 442
SITE 1 AC7 17 LYS C 631 ASN D 505 GLY D 506 ILE D 507
SITE 2 AC7 17 ILE D 508 TRP D 510 VAL D 514 PRO D 545
SITE 3 AC7 17 HIS D 546 SER D 547 GLY D 548 LYS D 549
SITE 4 AC7 17 THR D 550 LEU D 552 ASP D 604 ILE D 707
SITE 5 AC7 17 LYS D 708
SITE 1 AC8 19 ASP C 359 ARG C 385 ARG C 388 ILE D 220
SITE 2 AC8 19 PRO D 262 GLY D 263 CYS D 264 GLY D 265
SITE 3 AC8 19 LYS D 266 THR D 267 LEU D 268 ARG D 271
SITE 4 AC8 19 GLU D 329 ASN D 374 ILE D 406 HIS D 410
SITE 5 AC8 19 GLY D 438 ALA D 439 GLU D 442
SITE 1 AC9 15 LYS D 631 ASN E 505 GLY E 506 ILE E 507
SITE 2 AC9 15 ILE E 508 TRP E 510 VAL E 514 PRO E 545
SITE 3 AC9 15 HIS E 546 GLY E 548 LYS E 549 THR E 550
SITE 4 AC9 15 ASP E 604 ILE E 707 LYS E 708
SITE 1 AD1 15 ASP D 359 ALA D 382 ARG D 385 ARG D 388
SITE 2 AD1 15 ILE E 220 PRO E 262 GLY E 263 CYS E 264
SITE 3 AD1 15 GLY E 265 LYS E 266 THR E 267 LEU E 268
SITE 4 AD1 15 ASN E 374 ILE E 406 HIS E 410
SITE 1 AD2 14 LYS E 631 ASN F 505 ILE F 507 ILE F 508
SITE 2 AD2 14 TRP F 510 PRO F 545 HIS F 546 SER F 547
SITE 3 AD2 14 GLY F 548 LYS F 549 THR F 550 ASP F 604
SITE 4 AD2 14 ILE F 707 LYS F 708
CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 1
ORIGX1 1.000000 0.000000 0.000000 0.00000
ORIGX2 0.000000 1.000000 0.000000 0.00000
ORIGX3 0.000000 0.000000 1.000000 0.00000
SCALE1 1.000000 0.000000 0.000000 0.00000
SCALE2 0.000000 1.000000 0.000000 0.00000
SCALE3 0.000000 0.000000 1.000000 0.00000
(ATOM LINES ARE NOT SHOWN.)
END
