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Database: PDB
Entry: 6MDM
LinkDB: 6MDM
Original site: 6MDM 
HEADER    HYDROLASE                               04-SEP-18   6MDM              
TITLE     THE 20S SUPERCOMPLEX ENGAGING THE SNAP-25 N-TERMINUS (CLASS 1)        
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: VESICLE-FUSING ATPASE;                                     
COMPND   3 CHAIN: A, B, C, D, E, F;                                             
COMPND   4 SYNONYM: N-ETHYLMALEIMIDE-SENSITIVE FUSION PROTEIN,NEM-SENSITIVE     
COMPND   5 FUSION PROTEIN,VESICULAR-FUSION PROTEIN NSF;                         
COMPND   6 EC: 3.6.4.6;                                                         
COMPND   7 ENGINEERED: YES;                                                     
COMPND   8 MOL_ID: 2;                                                           
COMPND   9 MOLECULE: SYNAPTOSOMAL-ASSOCIATED PROTEIN 25;                        
COMPND  10 CHAIN: H;                                                            
COMPND  11 SYNONYM: SNAP-25,SUPER PROTEIN,SUP,SYNAPTOSOMAL-ASSOCIATED 25 KDA    
COMPND  12 PROTEIN;                                                             
COMPND  13 ENGINEERED: YES;                                                     
COMPND  14 MOL_ID: 3;                                                           
COMPND  15 MOLECULE: SYNTAXIN-1A;                                               
COMPND  16 CHAIN: I;                                                            
COMPND  17 SYNONYM: NEURON-SPECIFIC ANTIGEN HPC-1,SYNAPTOTAGMIN-ASSOCIATED 35   
COMPND  18 KDA PROTEIN,P35A;                                                    
COMPND  19 ENGINEERED: YES;                                                     
COMPND  20 MOL_ID: 4;                                                           
COMPND  21 MOLECULE: VESICLE-ASSOCIATED MEMBRANE PROTEIN 2;                     
COMPND  22 CHAIN: J;                                                            
COMPND  23 SYNONYM: VAMP-2,SYNAPTOBREVIN-2;                                     
COMPND  24 ENGINEERED: YES;                                                     
COMPND  25 MOL_ID: 5;                                                           
COMPND  26 MOLECULE: ALPHA-SOLUBLE NSF ATTACHMENT PROTEIN;                      
COMPND  27 CHAIN: K, L;                                                         
COMPND  28 SYNONYM: SNAP-ALPHA,N-ETHYLMALEIMIDE-SENSITIVE FACTOR ATTACHMENT     
COMPND  29 PROTEIN ALPHA;                                                       
COMPND  30 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: CRICETULUS GRISEUS;                             
SOURCE   3 ORGANISM_COMMON: CHINESE HAMSTER;                                    
SOURCE   4 ORGANISM_TAXID: 10029;                                               
SOURCE   5 GENE: NSF;                                                           
SOURCE   6 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE   8 MOL_ID: 2;                                                           
SOURCE   9 ORGANISM_SCIENTIFIC: RATTUS NORVEGICUS;                              
SOURCE  10 ORGANISM_COMMON: RAT;                                                
SOURCE  11 ORGANISM_TAXID: 10116;                                               
SOURCE  12 GENE: SNAP25, SNAP;                                                  
SOURCE  13 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  14 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE  15 MOL_ID: 3;                                                           
SOURCE  16 ORGANISM_SCIENTIFIC: RATTUS NORVEGICUS;                              
SOURCE  17 ORGANISM_COMMON: RAT;                                                
SOURCE  18 ORGANISM_TAXID: 10116;                                               
SOURCE  19 GENE: STX1A, SAP;                                                    
SOURCE  20 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  21 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE  22 MOL_ID: 4;                                                           
SOURCE  23 ORGANISM_SCIENTIFIC: RATTUS NORVEGICUS;                              
SOURCE  24 ORGANISM_COMMON: RAT;                                                
SOURCE  25 ORGANISM_TAXID: 10116;                                               
SOURCE  26 GENE: VAMP2, SYB2;                                                   
SOURCE  27 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  28 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE  29 MOL_ID: 5;                                                           
SOURCE  30 ORGANISM_SCIENTIFIC: RATTUS NORVEGICUS;                              
SOURCE  31 ORGANISM_COMMON: RAT;                                                
SOURCE  32 ORGANISM_TAXID: 10116;                                               
SOURCE  33 GENE: NAPA, SNAP, SNAPA;                                             
SOURCE  34 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  35 EXPRESSION_SYSTEM_TAXID: 562                                         
KEYWDS    SNARE, NSF, SNAP, ATPASE, AAA, DISASSEMBLY, SYNAPSE, MEMBRANE FUSION, 
KEYWDS   2 EXOCYTOSIS, HYDROLASE                                                
EXPDTA    ELECTRON MICROSCOPY                                                   
AUTHOR    K.I.WHITE,M.ZHAO,A.T.BRUNGER                                          
REVDAT   3   18-DEC-19 6MDM    1       SCALE                                    
REVDAT   2   26-SEP-18 6MDM    1       JRNL                                     
REVDAT   1   19-SEP-18 6MDM    0                                                
JRNL        AUTH   K.I.WHITE,M.ZHAO,U.B.CHOI,R.A.PFUETZNER,A.T.BRUNGER          
JRNL        TITL   STRUCTURAL PRINCIPLES OF SNARE COMPLEX RECOGNITION BY THE    
JRNL        TITL 2 AAA+ PROTEIN NSF.                                            
JRNL        REF    ELIFE                         V.   7       2018              
JRNL        REFN                   ESSN 2050-084X                               
JRNL        PMID   30198481                                                     
JRNL        DOI    10.7554/ELIFE.38888                                          
REMARK   2                                                                      
REMARK   2 RESOLUTION.    4.40 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   SOFTWARE PACKAGES      : SERIALEM, RELION, PHENIX, COOT, PHENIX,   
REMARK   3                            COOT, RELION, RELION, RELION, RELION      
REMARK   3   RECONSTRUCTION SCHEMA  : NULL                                      
REMARK   3                                                                      
REMARK   3 EM MAP-MODEL FITTING AND REFINEMENT                                  
REMARK   3   PDB ENTRY                    : 3J96                                
REMARK   3   REFINEMENT SPACE             : REAL                                
REMARK   3   REFINEMENT PROTOCOL          : RIGID BODY FIT                      
REMARK   3   REFINEMENT TARGET            : NULL                                
REMARK   3   OVERALL ANISOTROPIC B VALUE  : NULL                                
REMARK   3                                                                      
REMARK   3 FITTING PROCEDURE : NULL                                             
REMARK   3                                                                      
REMARK   3 EM IMAGE RECONSTRUCTION STATISTICS                                   
REMARK   3   NOMINAL PIXEL SIZE (ANGSTROMS)    : NULL                           
REMARK   3   ACTUAL PIXEL SIZE  (ANGSTROMS)    : NULL                           
REMARK   3   EFFECTIVE RESOLUTION (ANGSTROMS)  : 4.400                          
REMARK   3   NUMBER OF PARTICLES               : 55150                          
REMARK   3   CTF CORRECTION METHOD             : PHASE FLIPPING AND AMPLITUDE   
REMARK   3                                       CORRECTION                     
REMARK   3                                                                      
REMARK   3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL                    
REMARK   3                                                                      
REMARK   3 OTHER DETAILS: NULL                                                  
REMARK   4                                                                      
REMARK   4 6MDM COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 06-SEP-18.                  
REMARK 100 THE DEPOSITION ID IS D_1000236719.                                   
REMARK 245                                                                      
REMARK 245 EXPERIMENTAL DETAILS                                                 
REMARK 245   RECONSTRUCTION METHOD          : SINGLE PARTICLE                   
REMARK 245   SPECIMEN TYPE                  : NULL                              
REMARK 245                                                                      
REMARK 245 ELECTRON MICROSCOPE SAMPLE                                           
REMARK 245   SAMPLE TYPE                    : PARTICLE                          
REMARK 245   PARTICLE TYPE                  : POINT                             
REMARK 245   NAME OF SAMPLE                 : 20S SUPERCOMPLEX CONSISTING OF    
REMARK 245                                    SOLUBLE NEURONAL SNARE COMPLEX,   
REMARK 245                                    ALPHA-SNAP, AND N-                
REMARK 245                                    ETHYLMALEIMIDE SENSITIVE FACTOR   
REMARK 245                                    (NSF); N-ETHYLMALEIMIDE           
REMARK 245                                    SENSITIVE FACTOR; SYNAPTOSOMAL-   
REMARK 245                                    ASSOCIATED PROTEIN 25; SYNTAXIN-  
REMARK 245                                    1A; VESICLE-ASSOCIATED MEMBRANE   
REMARK 245                                    PROTEIN 2; ALPHA-SOLUBLE NSF      
REMARK 245                                    ATTACHMENT PROTEIN                
REMARK 245   SAMPLE CONCENTRATION (MG ML-1) : 15.00                             
REMARK 245   SAMPLE SUPPORT DETAILS         : NOT AVAILABLE                     
REMARK 245   SAMPLE VITRIFICATION DETAILS   : BLOT FOR 3.5 SECONDS BEFORE       
REMARK 245                                    PLUNGING.                         
REMARK 245   SAMPLE BUFFER                  : NULL                              
REMARK 245   PH                             : 8.00                              
REMARK 245   SAMPLE DETAILS                 : NULL                              
REMARK 245                                                                      
REMARK 245 DATA ACQUISITION                                                     
REMARK 245   DATE OF EXPERIMENT                : NULL                           
REMARK 245   NUMBER OF MICROGRAPHS-IMAGES      : 5418                           
REMARK 245   TEMPERATURE (KELVIN)              : NULL                           
REMARK 245   MICROSCOPE MODEL                  : FEI TITAN KRIOS                
REMARK 245   DETECTOR TYPE                     : GATAN K2 SUMMIT (4K X 4K)      
REMARK 245   MINIMUM DEFOCUS (NM)              : 1500.00                        
REMARK 245   MAXIMUM DEFOCUS (NM)              : 3000.00                        
REMARK 245   MINIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   MAXIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   NOMINAL CS                        : 2.70                           
REMARK 245   IMAGING MODE                      : BRIGHT FIELD                   
REMARK 245   ELECTRON DOSE (ELECTRONS NM**-2)  : 58.00                          
REMARK 245   ILLUMINATION MODE                 : FLOOD BEAM                     
REMARK 245   NOMINAL MAGNIFICATION             : NULL                           
REMARK 245   CALIBRATED MAGNIFICATION          : NULL                           
REMARK 245   SOURCE                            : FIELD EMISSION GUN             
REMARK 245   ACCELERATION VOLTAGE (KV)         : 300                            
REMARK 245   IMAGING DETAILS                   : NULL                           
REMARK 247                                                                      
REMARK 247 ELECTRON MICROSCOPY                                                  
REMARK 247  THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON          
REMARK 247  MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE              
REMARK 247  THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES           
REMARK 247  ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION         
REMARK 247  OF THE STRUCTURE FACTORS.                                           
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: UNDECAMERIC                       
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E, F, H, I, J, K,         
REMARK 350                    AND CHAINS: L                                     
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     MET A   -23                                                      
REMARK 465     GLY A   -22                                                      
REMARK 465     HIS A   -21                                                      
REMARK 465     HIS A   -20                                                      
REMARK 465     HIS A   -19                                                      
REMARK 465     HIS A   -18                                                      
REMARK 465     HIS A   -17                                                      
REMARK 465     HIS A   -16                                                      
REMARK 465     ASP A   -15                                                      
REMARK 465     TYR A   -14                                                      
REMARK 465     ASP A   -13                                                      
REMARK 465     ILE A   -12                                                      
REMARK 465     PRO A   -11                                                      
REMARK 465     THR A   -10                                                      
REMARK 465     THR A    -9                                                      
REMARK 465     GLU A    -8                                                      
REMARK 465     ASN A    -7                                                      
REMARK 465     LEU A    -6                                                      
REMARK 465     TYR A    -5                                                      
REMARK 465     PHE A    -4                                                      
REMARK 465     GLN A    -3                                                      
REMARK 465     GLY A    -2                                                      
REMARK 465     ALA A    -1                                                      
REMARK 465     HIS A     0                                                      
REMARK 465     ASP A   156                                                      
REMARK 465     PRO A   157                                                      
REMARK 465     SER A   158                                                      
REMARK 465     ILE A   159                                                      
REMARK 465     LEU A   160                                                      
REMARK 465     LYS A   161                                                      
REMARK 465     GLY A   162                                                      
REMARK 465     GLU A   163                                                      
REMARK 465     PRO A   164                                                      
REMARK 465     ALA A   165                                                      
REMARK 465     SER A   166                                                      
REMARK 465     GLY A   167                                                      
REMARK 465     LYS A   168                                                      
REMARK 465     LYS A   202                                                      
REMARK 465     GLU A   203                                                      
REMARK 465     ASN A   204                                                      
REMARK 465     ARG A   205                                                      
REMARK 465     GLN A   206                                                      
REMARK 465     SER A   207                                                      
REMARK 465     ILE A   208                                                      
REMARK 465     ILE A   209                                                      
REMARK 465     ASN A   210                                                      
REMARK 465     SER A   460                                                      
REMARK 465     THR A   461                                                      
REMARK 465     LYS A   462                                                      
REMARK 465     VAL A   463                                                      
REMARK 465     GLU A   464                                                      
REMARK 465     VAL A   465                                                      
REMARK 465     ASP A   466                                                      
REMARK 465     MET A   467                                                      
REMARK 465     GLU A   468                                                      
REMARK 465     LYS A   469                                                      
REMARK 465     ALA A   470                                                      
REMARK 465     GLU A   471                                                      
REMARK 465     SER A   472                                                      
REMARK 465     LEU A   473                                                      
REMARK 465     GLN A   474                                                      
REMARK 465     VAL A   475                                                      
REMARK 465     THR A   476                                                      
REMARK 465     SER A   739                                                      
REMARK 465     PRO A   740                                                      
REMARK 465     LEU A   741                                                      
REMARK 465     ASP A   742                                                      
REMARK 465     PHE A   743                                                      
REMARK 465     ASP A   744                                                      
REMARK 465     MET B   -23                                                      
REMARK 465     GLY B   -22                                                      
REMARK 465     HIS B   -21                                                      
REMARK 465     HIS B   -20                                                      
REMARK 465     HIS B   -19                                                      
REMARK 465     HIS B   -18                                                      
REMARK 465     HIS B   -17                                                      
REMARK 465     HIS B   -16                                                      
REMARK 465     ASP B   -15                                                      
REMARK 465     TYR B   -14                                                      
REMARK 465     ASP B   -13                                                      
REMARK 465     ILE B   -12                                                      
REMARK 465     PRO B   -11                                                      
REMARK 465     THR B   -10                                                      
REMARK 465     THR B    -9                                                      
REMARK 465     GLU B    -8                                                      
REMARK 465     ASN B    -7                                                      
REMARK 465     LEU B    -6                                                      
REMARK 465     TYR B    -5                                                      
REMARK 465     PHE B    -4                                                      
REMARK 465     GLN B    -3                                                      
REMARK 465     GLY B    -2                                                      
REMARK 465     ALA B    -1                                                      
REMARK 465     HIS B     0                                                      
REMARK 465     ASP B   156                                                      
REMARK 465     PRO B   157                                                      
REMARK 465     SER B   158                                                      
REMARK 465     ILE B   159                                                      
REMARK 465     LEU B   160                                                      
REMARK 465     LYS B   161                                                      
REMARK 465     GLY B   162                                                      
REMARK 465     GLU B   163                                                      
REMARK 465     PRO B   164                                                      
REMARK 465     ALA B   165                                                      
REMARK 465     SER B   166                                                      
REMARK 465     GLY B   167                                                      
REMARK 465     LYS B   168                                                      
REMARK 465     LYS B   202                                                      
REMARK 465     GLU B   203                                                      
REMARK 465     ASN B   204                                                      
REMARK 465     ARG B   205                                                      
REMARK 465     GLN B   206                                                      
REMARK 465     SER B   207                                                      
REMARK 465     ILE B   208                                                      
REMARK 465     THR B   461                                                      
REMARK 465     LYS B   462                                                      
REMARK 465     VAL B   463                                                      
REMARK 465     GLU B   464                                                      
REMARK 465     VAL B   465                                                      
REMARK 465     ASP B   466                                                      
REMARK 465     MET B   467                                                      
REMARK 465     GLU B   468                                                      
REMARK 465     LYS B   469                                                      
REMARK 465     ALA B   470                                                      
REMARK 465     GLU B   471                                                      
REMARK 465     SER B   472                                                      
REMARK 465     LEU B   473                                                      
REMARK 465     GLN B   474                                                      
REMARK 465     SER B   739                                                      
REMARK 465     PRO B   740                                                      
REMARK 465     LEU B   741                                                      
REMARK 465     ASP B   742                                                      
REMARK 465     PHE B   743                                                      
REMARK 465     ASP B   744                                                      
REMARK 465     MET C   -23                                                      
REMARK 465     GLY C   -22                                                      
REMARK 465     HIS C   -21                                                      
REMARK 465     HIS C   -20                                                      
REMARK 465     HIS C   -19                                                      
REMARK 465     HIS C   -18                                                      
REMARK 465     HIS C   -17                                                      
REMARK 465     HIS C   -16                                                      
REMARK 465     ASP C   -15                                                      
REMARK 465     TYR C   -14                                                      
REMARK 465     ASP C   -13                                                      
REMARK 465     ILE C   -12                                                      
REMARK 465     PRO C   -11                                                      
REMARK 465     THR C   -10                                                      
REMARK 465     THR C    -9                                                      
REMARK 465     GLU C    -8                                                      
REMARK 465     ASN C    -7                                                      
REMARK 465     LEU C    -6                                                      
REMARK 465     TYR C    -5                                                      
REMARK 465     PHE C    -4                                                      
REMARK 465     GLN C    -3                                                      
REMARK 465     GLY C    -2                                                      
REMARK 465     ALA C    -1                                                      
REMARK 465     HIS C     0                                                      
REMARK 465     ASP C   156                                                      
REMARK 465     PRO C   157                                                      
REMARK 465     SER C   158                                                      
REMARK 465     ILE C   159                                                      
REMARK 465     LEU C   160                                                      
REMARK 465     LYS C   161                                                      
REMARK 465     GLY C   162                                                      
REMARK 465     GLU C   163                                                      
REMARK 465     PRO C   164                                                      
REMARK 465     ALA C   165                                                      
REMARK 465     SER C   166                                                      
REMARK 465     GLY C   167                                                      
REMARK 465     LYS C   168                                                      
REMARK 465     LYS C   202                                                      
REMARK 465     GLU C   203                                                      
REMARK 465     ASN C   204                                                      
REMARK 465     ARG C   205                                                      
REMARK 465     GLN C   206                                                      
REMARK 465     SER C   207                                                      
REMARK 465     ILE C   458                                                      
REMARK 465     ALA C   459                                                      
REMARK 465     SER C   460                                                      
REMARK 465     THR C   461                                                      
REMARK 465     LYS C   462                                                      
REMARK 465     VAL C   463                                                      
REMARK 465     GLU C   464                                                      
REMARK 465     VAL C   465                                                      
REMARK 465     ASP C   466                                                      
REMARK 465     MET C   467                                                      
REMARK 465     SER C   739                                                      
REMARK 465     PRO C   740                                                      
REMARK 465     LEU C   741                                                      
REMARK 465     ASP C   742                                                      
REMARK 465     PHE C   743                                                      
REMARK 465     ASP C   744                                                      
REMARK 465     MET D   -23                                                      
REMARK 465     GLY D   -22                                                      
REMARK 465     HIS D   -21                                                      
REMARK 465     HIS D   -20                                                      
REMARK 465     HIS D   -19                                                      
REMARK 465     HIS D   -18                                                      
REMARK 465     HIS D   -17                                                      
REMARK 465     HIS D   -16                                                      
REMARK 465     ASP D   -15                                                      
REMARK 465     TYR D   -14                                                      
REMARK 465     ASP D   -13                                                      
REMARK 465     ILE D   -12                                                      
REMARK 465     PRO D   -11                                                      
REMARK 465     THR D   -10                                                      
REMARK 465     THR D    -9                                                      
REMARK 465     GLU D    -8                                                      
REMARK 465     ASN D    -7                                                      
REMARK 465     LEU D    -6                                                      
REMARK 465     TYR D    -5                                                      
REMARK 465     PHE D    -4                                                      
REMARK 465     GLN D    -3                                                      
REMARK 465     GLY D    -2                                                      
REMARK 465     ALA D    -1                                                      
REMARK 465     HIS D     0                                                      
REMARK 465     ASP D   156                                                      
REMARK 465     PRO D   157                                                      
REMARK 465     SER D   158                                                      
REMARK 465     ILE D   159                                                      
REMARK 465     LEU D   160                                                      
REMARK 465     LYS D   161                                                      
REMARK 465     GLY D   162                                                      
REMARK 465     GLU D   163                                                      
REMARK 465     PRO D   164                                                      
REMARK 465     ALA D   165                                                      
REMARK 465     SER D   166                                                      
REMARK 465     GLY D   167                                                      
REMARK 465     LYS D   168                                                      
REMARK 465     LYS D   202                                                      
REMARK 465     GLU D   203                                                      
REMARK 465     ASN D   204                                                      
REMARK 465     ARG D   205                                                      
REMARK 465     GLN D   206                                                      
REMARK 465     SER D   207                                                      
REMARK 465     ALA D   459                                                      
REMARK 465     SER D   460                                                      
REMARK 465     THR D   461                                                      
REMARK 465     LYS D   462                                                      
REMARK 465     VAL D   463                                                      
REMARK 465     GLU D   464                                                      
REMARK 465     SER D   739                                                      
REMARK 465     PRO D   740                                                      
REMARK 465     LEU D   741                                                      
REMARK 465     ASP D   742                                                      
REMARK 465     PHE D   743                                                      
REMARK 465     ASP D   744                                                      
REMARK 465     MET E   -23                                                      
REMARK 465     GLY E   -22                                                      
REMARK 465     HIS E   -21                                                      
REMARK 465     HIS E   -20                                                      
REMARK 465     HIS E   -19                                                      
REMARK 465     HIS E   -18                                                      
REMARK 465     HIS E   -17                                                      
REMARK 465     HIS E   -16                                                      
REMARK 465     ASP E   -15                                                      
REMARK 465     TYR E   -14                                                      
REMARK 465     ASP E   -13                                                      
REMARK 465     ILE E   -12                                                      
REMARK 465     PRO E   -11                                                      
REMARK 465     THR E   -10                                                      
REMARK 465     THR E    -9                                                      
REMARK 465     GLU E    -8                                                      
REMARK 465     ASN E    -7                                                      
REMARK 465     LEU E    -6                                                      
REMARK 465     TYR E    -5                                                      
REMARK 465     PHE E    -4                                                      
REMARK 465     GLN E    -3                                                      
REMARK 465     GLY E    -2                                                      
REMARK 465     ALA E    -1                                                      
REMARK 465     HIS E     0                                                      
REMARK 465     MET E     1                                                      
REMARK 465     ALA E     2                                                      
REMARK 465     GLY E     3                                                      
REMARK 465     ARG E     4                                                      
REMARK 465     SER E     5                                                      
REMARK 465     MET E     6                                                      
REMARK 465     GLN E     7                                                      
REMARK 465     ALA E     8                                                      
REMARK 465     ALA E     9                                                      
REMARK 465     ARG E    10                                                      
REMARK 465     CYS E    11                                                      
REMARK 465     PRO E    12                                                      
REMARK 465     THR E    13                                                      
REMARK 465     ASP E    14                                                      
REMARK 465     GLU E    15                                                      
REMARK 465     LEU E    16                                                      
REMARK 465     SER E    17                                                      
REMARK 465     LEU E    18                                                      
REMARK 465     SER E    19                                                      
REMARK 465     ASN E    20                                                      
REMARK 465     CYS E    21                                                      
REMARK 465     ALA E    22                                                      
REMARK 465     VAL E    23                                                      
REMARK 465     VAL E    24                                                      
REMARK 465     SER E    25                                                      
REMARK 465     GLU E    26                                                      
REMARK 465     LYS E    27                                                      
REMARK 465     ASP E    28                                                      
REMARK 465     TYR E    29                                                      
REMARK 465     GLN E    30                                                      
REMARK 465     SER E    31                                                      
REMARK 465     GLY E    32                                                      
REMARK 465     GLN E    33                                                      
REMARK 465     HIS E    34                                                      
REMARK 465     VAL E    35                                                      
REMARK 465     ILE E    36                                                      
REMARK 465     VAL E    37                                                      
REMARK 465     ARG E    38                                                      
REMARK 465     THR E    39                                                      
REMARK 465     SER E    40                                                      
REMARK 465     PRO E    41                                                      
REMARK 465     ASN E    42                                                      
REMARK 465     HIS E    43                                                      
REMARK 465     LYS E    44                                                      
REMARK 465     TYR E    45                                                      
REMARK 465     ILE E    46                                                      
REMARK 465     PHE E    47                                                      
REMARK 465     THR E    48                                                      
REMARK 465     LEU E    49                                                      
REMARK 465     ARG E    50                                                      
REMARK 465     THR E    51                                                      
REMARK 465     HIS E    52                                                      
REMARK 465     PRO E    53                                                      
REMARK 465     SER E    54                                                      
REMARK 465     VAL E    55                                                      
REMARK 465     VAL E    56                                                      
REMARK 465     PRO E    57                                                      
REMARK 465     GLY E    58                                                      
REMARK 465     SER E    59                                                      
REMARK 465     VAL E    60                                                      
REMARK 465     ALA E    61                                                      
REMARK 465     PHE E    62                                                      
REMARK 465     SER E    63                                                      
REMARK 465     LEU E    64                                                      
REMARK 465     PRO E    65                                                      
REMARK 465     GLN E    66                                                      
REMARK 465     ARG E    67                                                      
REMARK 465     LYS E    68                                                      
REMARK 465     TRP E    69                                                      
REMARK 465     ALA E    70                                                      
REMARK 465     GLY E    71                                                      
REMARK 465     LEU E    72                                                      
REMARK 465     SER E    73                                                      
REMARK 465     ILE E    74                                                      
REMARK 465     GLY E    75                                                      
REMARK 465     GLN E    76                                                      
REMARK 465     GLU E    77                                                      
REMARK 465     ILE E    78                                                      
REMARK 465     GLU E    79                                                      
REMARK 465     VAL E    80                                                      
REMARK 465     ALA E    81                                                      
REMARK 465     LEU E    82                                                      
REMARK 465     TYR E    83                                                      
REMARK 465     SER E    84                                                      
REMARK 465     PHE E    85                                                      
REMARK 465     ASP E    86                                                      
REMARK 465     LYS E    87                                                      
REMARK 465     ALA E    88                                                      
REMARK 465     LYS E    89                                                      
REMARK 465     GLN E    90                                                      
REMARK 465     CYS E    91                                                      
REMARK 465     ILE E    92                                                      
REMARK 465     GLY E    93                                                      
REMARK 465     THR E    94                                                      
REMARK 465     MET E    95                                                      
REMARK 465     THR E    96                                                      
REMARK 465     ILE E    97                                                      
REMARK 465     GLU E    98                                                      
REMARK 465     ILE E    99                                                      
REMARK 465     ASP E   100                                                      
REMARK 465     PHE E   101                                                      
REMARK 465     LEU E   102                                                      
REMARK 465     GLN E   103                                                      
REMARK 465     LYS E   104                                                      
REMARK 465     LYS E   105                                                      
REMARK 465     ASN E   106                                                      
REMARK 465     ILE E   107                                                      
REMARK 465     ASP E   108                                                      
REMARK 465     SER E   109                                                      
REMARK 465     ASN E   110                                                      
REMARK 465     PRO E   111                                                      
REMARK 465     TYR E   112                                                      
REMARK 465     ASP E   113                                                      
REMARK 465     THR E   114                                                      
REMARK 465     ASP E   115                                                      
REMARK 465     LYS E   116                                                      
REMARK 465     MET E   117                                                      
REMARK 465     ALA E   118                                                      
REMARK 465     ALA E   119                                                      
REMARK 465     GLU E   120                                                      
REMARK 465     PHE E   121                                                      
REMARK 465     ILE E   122                                                      
REMARK 465     GLN E   123                                                      
REMARK 465     GLN E   124                                                      
REMARK 465     PHE E   125                                                      
REMARK 465     ASN E   126                                                      
REMARK 465     ASN E   127                                                      
REMARK 465     GLN E   128                                                      
REMARK 465     ALA E   129                                                      
REMARK 465     PHE E   130                                                      
REMARK 465     SER E   131                                                      
REMARK 465     VAL E   132                                                      
REMARK 465     GLY E   133                                                      
REMARK 465     GLN E   134                                                      
REMARK 465     GLN E   135                                                      
REMARK 465     LEU E   136                                                      
REMARK 465     VAL E   137                                                      
REMARK 465     PHE E   138                                                      
REMARK 465     SER E   139                                                      
REMARK 465     PHE E   140                                                      
REMARK 465     ASN E   141                                                      
REMARK 465     ASP E   142                                                      
REMARK 465     LYS E   143                                                      
REMARK 465     LEU E   144                                                      
REMARK 465     PHE E   145                                                      
REMARK 465     GLY E   146                                                      
REMARK 465     LEU E   147                                                      
REMARK 465     LEU E   148                                                      
REMARK 465     VAL E   149                                                      
REMARK 465     LYS E   150                                                      
REMARK 465     ASP E   151                                                      
REMARK 465     ILE E   152                                                      
REMARK 465     GLU E   153                                                      
REMARK 465     ALA E   154                                                      
REMARK 465     MET E   155                                                      
REMARK 465     ASP E   156                                                      
REMARK 465     PRO E   157                                                      
REMARK 465     SER E   158                                                      
REMARK 465     ILE E   159                                                      
REMARK 465     LEU E   160                                                      
REMARK 465     LYS E   161                                                      
REMARK 465     GLY E   162                                                      
REMARK 465     GLU E   163                                                      
REMARK 465     PRO E   164                                                      
REMARK 465     ALA E   165                                                      
REMARK 465     SER E   166                                                      
REMARK 465     GLY E   167                                                      
REMARK 465     LYS E   168                                                      
REMARK 465     ARG E   169                                                      
REMARK 465     GLN E   170                                                      
REMARK 465     LYS E   171                                                      
REMARK 465     ILE E   172                                                      
REMARK 465     GLU E   173                                                      
REMARK 465     VAL E   174                                                      
REMARK 465     GLY E   175                                                      
REMARK 465     LEU E   176                                                      
REMARK 465     VAL E   177                                                      
REMARK 465     VAL E   178                                                      
REMARK 465     GLY E   179                                                      
REMARK 465     ASN E   180                                                      
REMARK 465     SER E   181                                                      
REMARK 465     GLN E   182                                                      
REMARK 465     VAL E   183                                                      
REMARK 465     ALA E   184                                                      
REMARK 465     PHE E   185                                                      
REMARK 465     GLU E   186                                                      
REMARK 465     LYS E   187                                                      
REMARK 465     ALA E   188                                                      
REMARK 465     GLU E   189                                                      
REMARK 465     ASN E   190                                                      
REMARK 465     SER E   191                                                      
REMARK 465     SER E   192                                                      
REMARK 465     LEU E   193                                                      
REMARK 465     ASN E   194                                                      
REMARK 465     LEU E   195                                                      
REMARK 465     ILE E   196                                                      
REMARK 465     GLY E   197                                                      
REMARK 465     LYS E   198                                                      
REMARK 465     ALA E   199                                                      
REMARK 465     LYS E   200                                                      
REMARK 465     THR E   201                                                      
REMARK 465     LYS E   202                                                      
REMARK 465     GLU E   203                                                      
REMARK 465     ASN E   204                                                      
REMARK 465     ARG E   205                                                      
REMARK 465     GLN E   206                                                      
REMARK 465     SER E   207                                                      
REMARK 465     ILE E   208                                                      
REMARK 465     ILE E   209                                                      
REMARK 465     PRO E   241                                                      
REMARK 465     PRO E   242                                                      
REMARK 465     GLU E   243                                                      
REMARK 465     ILE E   244                                                      
REMARK 465     VAL E   245                                                      
REMARK 465     GLU E   246                                                      
REMARK 465     GLN E   247                                                      
REMARK 465     MET E   248                                                      
REMARK 465     GLY E   249                                                      
REMARK 465     ALA E   459                                                      
REMARK 465     SER E   460                                                      
REMARK 465     THR E   461                                                      
REMARK 465     LYS E   462                                                      
REMARK 465     VAL E   463                                                      
REMARK 465     GLU E   464                                                      
REMARK 465     SER E   739                                                      
REMARK 465     PRO E   740                                                      
REMARK 465     LEU E   741                                                      
REMARK 465     ASP E   742                                                      
REMARK 465     PHE E   743                                                      
REMARK 465     ASP E   744                                                      
REMARK 465     MET F   -23                                                      
REMARK 465     GLY F   -22                                                      
REMARK 465     HIS F   -21                                                      
REMARK 465     HIS F   -20                                                      
REMARK 465     HIS F   -19                                                      
REMARK 465     HIS F   -18                                                      
REMARK 465     HIS F   -17                                                      
REMARK 465     HIS F   -16                                                      
REMARK 465     ASP F   -15                                                      
REMARK 465     TYR F   -14                                                      
REMARK 465     ASP F   -13                                                      
REMARK 465     ILE F   -12                                                      
REMARK 465     PRO F   -11                                                      
REMARK 465     THR F   -10                                                      
REMARK 465     THR F    -9                                                      
REMARK 465     GLU F    -8                                                      
REMARK 465     ASN F    -7                                                      
REMARK 465     LEU F    -6                                                      
REMARK 465     TYR F    -5                                                      
REMARK 465     PHE F    -4                                                      
REMARK 465     GLN F    -3                                                      
REMARK 465     GLY F    -2                                                      
REMARK 465     ALA F    -1                                                      
REMARK 465     HIS F     0                                                      
REMARK 465     MET F     1                                                      
REMARK 465     ALA F     2                                                      
REMARK 465     GLY F     3                                                      
REMARK 465     ARG F     4                                                      
REMARK 465     SER F     5                                                      
REMARK 465     MET F     6                                                      
REMARK 465     GLN F     7                                                      
REMARK 465     ALA F     8                                                      
REMARK 465     ALA F     9                                                      
REMARK 465     ARG F    10                                                      
REMARK 465     CYS F    11                                                      
REMARK 465     PRO F    12                                                      
REMARK 465     THR F    13                                                      
REMARK 465     ASP F    14                                                      
REMARK 465     GLU F    15                                                      
REMARK 465     LEU F    16                                                      
REMARK 465     SER F    17                                                      
REMARK 465     LEU F    18                                                      
REMARK 465     SER F    19                                                      
REMARK 465     ASN F    20                                                      
REMARK 465     CYS F    21                                                      
REMARK 465     ALA F    22                                                      
REMARK 465     VAL F    23                                                      
REMARK 465     VAL F    24                                                      
REMARK 465     SER F    25                                                      
REMARK 465     GLU F    26                                                      
REMARK 465     LYS F    27                                                      
REMARK 465     ASP F    28                                                      
REMARK 465     TYR F    29                                                      
REMARK 465     GLN F    30                                                      
REMARK 465     SER F    31                                                      
REMARK 465     GLY F    32                                                      
REMARK 465     GLN F    33                                                      
REMARK 465     HIS F    34                                                      
REMARK 465     VAL F    35                                                      
REMARK 465     ILE F    36                                                      
REMARK 465     VAL F    37                                                      
REMARK 465     ARG F    38                                                      
REMARK 465     THR F    39                                                      
REMARK 465     SER F    40                                                      
REMARK 465     PRO F    41                                                      
REMARK 465     ASN F    42                                                      
REMARK 465     HIS F    43                                                      
REMARK 465     LYS F    44                                                      
REMARK 465     TYR F    45                                                      
REMARK 465     ILE F    46                                                      
REMARK 465     PHE F    47                                                      
REMARK 465     THR F    48                                                      
REMARK 465     LEU F    49                                                      
REMARK 465     ARG F    50                                                      
REMARK 465     THR F    51                                                      
REMARK 465     HIS F    52                                                      
REMARK 465     PRO F    53                                                      
REMARK 465     SER F    54                                                      
REMARK 465     VAL F    55                                                      
REMARK 465     VAL F    56                                                      
REMARK 465     PRO F    57                                                      
REMARK 465     GLY F    58                                                      
REMARK 465     SER F    59                                                      
REMARK 465     VAL F    60                                                      
REMARK 465     ALA F    61                                                      
REMARK 465     PHE F    62                                                      
REMARK 465     SER F    63                                                      
REMARK 465     LEU F    64                                                      
REMARK 465     PRO F    65                                                      
REMARK 465     GLN F    66                                                      
REMARK 465     ARG F    67                                                      
REMARK 465     LYS F    68                                                      
REMARK 465     TRP F    69                                                      
REMARK 465     ALA F    70                                                      
REMARK 465     GLY F    71                                                      
REMARK 465     LEU F    72                                                      
REMARK 465     SER F    73                                                      
REMARK 465     ILE F    74                                                      
REMARK 465     GLY F    75                                                      
REMARK 465     GLN F    76                                                      
REMARK 465     GLU F    77                                                      
REMARK 465     ILE F    78                                                      
REMARK 465     GLU F    79                                                      
REMARK 465     VAL F    80                                                      
REMARK 465     ALA F    81                                                      
REMARK 465     LEU F    82                                                      
REMARK 465     TYR F    83                                                      
REMARK 465     SER F    84                                                      
REMARK 465     PHE F    85                                                      
REMARK 465     ASP F    86                                                      
REMARK 465     LYS F    87                                                      
REMARK 465     ALA F    88                                                      
REMARK 465     LYS F    89                                                      
REMARK 465     GLN F    90                                                      
REMARK 465     CYS F    91                                                      
REMARK 465     ILE F    92                                                      
REMARK 465     GLY F    93                                                      
REMARK 465     THR F    94                                                      
REMARK 465     MET F    95                                                      
REMARK 465     THR F    96                                                      
REMARK 465     ILE F    97                                                      
REMARK 465     GLU F    98                                                      
REMARK 465     ILE F    99                                                      
REMARK 465     ASP F   100                                                      
REMARK 465     PHE F   101                                                      
REMARK 465     LEU F   102                                                      
REMARK 465     GLN F   103                                                      
REMARK 465     LYS F   104                                                      
REMARK 465     LYS F   105                                                      
REMARK 465     ASN F   106                                                      
REMARK 465     ILE F   107                                                      
REMARK 465     ASP F   108                                                      
REMARK 465     SER F   109                                                      
REMARK 465     ASN F   110                                                      
REMARK 465     PRO F   111                                                      
REMARK 465     TYR F   112                                                      
REMARK 465     ASP F   113                                                      
REMARK 465     THR F   114                                                      
REMARK 465     ASP F   115                                                      
REMARK 465     LYS F   116                                                      
REMARK 465     MET F   117                                                      
REMARK 465     ALA F   118                                                      
REMARK 465     ALA F   119                                                      
REMARK 465     GLU F   120                                                      
REMARK 465     PHE F   121                                                      
REMARK 465     ILE F   122                                                      
REMARK 465     GLN F   123                                                      
REMARK 465     GLN F   124                                                      
REMARK 465     PHE F   125                                                      
REMARK 465     ASN F   126                                                      
REMARK 465     ASN F   127                                                      
REMARK 465     GLN F   128                                                      
REMARK 465     ALA F   129                                                      
REMARK 465     PHE F   130                                                      
REMARK 465     SER F   131                                                      
REMARK 465     VAL F   132                                                      
REMARK 465     GLY F   133                                                      
REMARK 465     GLN F   134                                                      
REMARK 465     GLN F   135                                                      
REMARK 465     LEU F   136                                                      
REMARK 465     VAL F   137                                                      
REMARK 465     PHE F   138                                                      
REMARK 465     SER F   139                                                      
REMARK 465     PHE F   140                                                      
REMARK 465     ASN F   141                                                      
REMARK 465     ASP F   142                                                      
REMARK 465     LYS F   143                                                      
REMARK 465     LEU F   144                                                      
REMARK 465     PHE F   145                                                      
REMARK 465     GLY F   146                                                      
REMARK 465     LEU F   147                                                      
REMARK 465     LEU F   148                                                      
REMARK 465     VAL F   149                                                      
REMARK 465     LYS F   150                                                      
REMARK 465     ASP F   151                                                      
REMARK 465     ILE F   152                                                      
REMARK 465     GLU F   153                                                      
REMARK 465     ALA F   154                                                      
REMARK 465     MET F   155                                                      
REMARK 465     ASP F   156                                                      
REMARK 465     PRO F   157                                                      
REMARK 465     SER F   158                                                      
REMARK 465     ILE F   159                                                      
REMARK 465     LEU F   160                                                      
REMARK 465     LYS F   161                                                      
REMARK 465     GLY F   162                                                      
REMARK 465     GLU F   163                                                      
REMARK 465     PRO F   164                                                      
REMARK 465     ALA F   165                                                      
REMARK 465     SER F   166                                                      
REMARK 465     GLY F   167                                                      
REMARK 465     LYS F   168                                                      
REMARK 465     ARG F   169                                                      
REMARK 465     GLN F   170                                                      
REMARK 465     LYS F   171                                                      
REMARK 465     ILE F   172                                                      
REMARK 465     GLU F   173                                                      
REMARK 465     VAL F   174                                                      
REMARK 465     GLY F   175                                                      
REMARK 465     LEU F   176                                                      
REMARK 465     VAL F   177                                                      
REMARK 465     VAL F   178                                                      
REMARK 465     GLY F   179                                                      
REMARK 465     ASN F   180                                                      
REMARK 465     SER F   181                                                      
REMARK 465     GLN F   182                                                      
REMARK 465     VAL F   183                                                      
REMARK 465     ALA F   184                                                      
REMARK 465     PHE F   185                                                      
REMARK 465     GLU F   186                                                      
REMARK 465     LYS F   187                                                      
REMARK 465     ALA F   188                                                      
REMARK 465     GLU F   189                                                      
REMARK 465     ASN F   190                                                      
REMARK 465     SER F   191                                                      
REMARK 465     SER F   192                                                      
REMARK 465     LEU F   193                                                      
REMARK 465     ASN F   194                                                      
REMARK 465     LEU F   195                                                      
REMARK 465     ILE F   196                                                      
REMARK 465     GLY F   197                                                      
REMARK 465     LYS F   198                                                      
REMARK 465     ALA F   199                                                      
REMARK 465     LYS F   200                                                      
REMARK 465     THR F   201                                                      
REMARK 465     LYS F   202                                                      
REMARK 465     GLU F   203                                                      
REMARK 465     ASN F   204                                                      
REMARK 465     ARG F   205                                                      
REMARK 465     GLN F   206                                                      
REMARK 465     SER F   207                                                      
REMARK 465     ILE F   208                                                      
REMARK 465     ILE F   209                                                      
REMARK 465     ASN F   210                                                      
REMARK 465     PRO F   211                                                      
REMARK 465     ASP F   212                                                      
REMARK 465     TRP F   213                                                      
REMARK 465     ASN F   214                                                      
REMARK 465     PHE F   215                                                      
REMARK 465     GLU F   216                                                      
REMARK 465     LYS F   217                                                      
REMARK 465     MET F   218                                                      
REMARK 465     PHE F   240                                                      
REMARK 465     PRO F   241                                                      
REMARK 465     PRO F   242                                                      
REMARK 465     GLU F   243                                                      
REMARK 465     ILE F   244                                                      
REMARK 465     VAL F   245                                                      
REMARK 465     GLU F   246                                                      
REMARK 465     GLN F   247                                                      
REMARK 465     MET F   248                                                      
REMARK 465     GLY F   249                                                      
REMARK 465     CYS F   250                                                      
REMARK 465     ASP F   331                                                      
REMARK 465     ALA F   332                                                      
REMARK 465     ILE F   333                                                      
REMARK 465     CYS F   334                                                      
REMARK 465     LYS F   335                                                      
REMARK 465     GLN F   336                                                      
REMARK 465     ARG F   337                                                      
REMARK 465     GLY F   338                                                      
REMARK 465     SER F   339                                                      
REMARK 465     MET F   340                                                      
REMARK 465     ALA F   341                                                      
REMARK 465     GLY F   342                                                      
REMARK 465     SER F   343                                                      
REMARK 465     THR F   344                                                      
REMARK 465     GLY F   345                                                      
REMARK 465     VAL F   346                                                      
REMARK 465     VAL F   391                                                      
REMARK 465     LYS F   392                                                      
REMARK 465     MET F   393                                                      
REMARK 465     GLU F   394                                                      
REMARK 465     ILE F   395                                                      
REMARK 465     GLY F   396                                                      
REMARK 465     LEU F   397                                                      
REMARK 465     ARG F   415                                                      
REMARK 465     GLY F   416                                                      
REMARK 465     HIS F   417                                                      
REMARK 465     GLN F   418                                                      
REMARK 465     LEU F   419                                                      
REMARK 465     LEU F   420                                                      
REMARK 465     SER F   421                                                      
REMARK 465     ILE F   458                                                      
REMARK 465     ALA F   459                                                      
REMARK 465     SER F   460                                                      
REMARK 465     THR F   461                                                      
REMARK 465     LYS F   462                                                      
REMARK 465     VAL F   463                                                      
REMARK 465     GLU F   464                                                      
REMARK 465     VAL F   465                                                      
REMARK 465     ASP F   466                                                      
REMARK 465     MET F   467                                                      
REMARK 465     GLU F   468                                                      
REMARK 465     LYS F   469                                                      
REMARK 465     ALA F   470                                                      
REMARK 465     SER F   739                                                      
REMARK 465     PRO F   740                                                      
REMARK 465     LEU F   741                                                      
REMARK 465     ASP F   742                                                      
REMARK 465     PHE F   743                                                      
REMARK 465     ASP F   744                                                      
REMARK 465     MET H    -2                                                      
REMARK 465     ALA H    -1                                                      
REMARK 465     SER H     0                                                      
REMARK 465     CYS H    84                                                      
REMARK 465     CYS H    85                                                      
REMARK 465     GLY H    86                                                      
REMARK 465     LEU H    87                                                      
REMARK 465     PHE H    88                                                      
REMARK 465     ILE H    89                                                      
REMARK 465     CYS H    90                                                      
REMARK 465     PRO H    91                                                      
REMARK 465     CYS H    92                                                      
REMARK 465     ASN H    93                                                      
REMARK 465     LYS H    94                                                      
REMARK 465     LEU H    95                                                      
REMARK 465     LYS H    96                                                      
REMARK 465     SER H    97                                                      
REMARK 465     SER H    98                                                      
REMARK 465     ASP H    99                                                      
REMARK 465     ALA H   100                                                      
REMARK 465     TYR H   101                                                      
REMARK 465     LYS H   102                                                      
REMARK 465     LYS H   103                                                      
REMARK 465     ALA H   104                                                      
REMARK 465     TRP H   105                                                      
REMARK 465     GLY H   106                                                      
REMARK 465     ASN H   107                                                      
REMARK 465     ASN H   108                                                      
REMARK 465     GLN H   109                                                      
REMARK 465     ASP H   110                                                      
REMARK 465     GLY H   111                                                      
REMARK 465     VAL H   112                                                      
REMARK 465     VAL H   113                                                      
REMARK 465     ALA H   114                                                      
REMARK 465     SER H   115                                                      
REMARK 465     GLN H   116                                                      
REMARK 465     PRO H   117                                                      
REMARK 465     ALA H   118                                                      
REMARK 465     ARG H   119                                                      
REMARK 465     VAL H   120                                                      
REMARK 465     VAL H   121                                                      
REMARK 465     ASP H   122                                                      
REMARK 465     GLU H   123                                                      
REMARK 465     ARG H   124                                                      
REMARK 465     GLU H   125                                                      
REMARK 465     GLN H   126                                                      
REMARK 465     MET H   127                                                      
REMARK 465     ALA H   128                                                      
REMARK 465     ILE H   129                                                      
REMARK 465     SER H   130                                                      
REMARK 465     GLY H   131                                                      
REMARK 465     GLY H   132                                                      
REMARK 465     PHE H   133                                                      
REMARK 465     ILE H   134                                                      
REMARK 465     ARG H   135                                                      
REMARK 465     ARG H   136                                                      
REMARK 465     VAL H   137                                                      
REMARK 465     THR H   138                                                      
REMARK 465     ASN H   139                                                      
REMARK 465     ASP H   140                                                      
REMARK 465     MET I     1                                                      
REMARK 465     LYS I     2                                                      
REMARK 465     ASP I     3                                                      
REMARK 465     ARG I     4                                                      
REMARK 465     THR I     5                                                      
REMARK 465     GLN I     6                                                      
REMARK 465     GLU I     7                                                      
REMARK 465     LEU I     8                                                      
REMARK 465     ARG I     9                                                      
REMARK 465     THR I    10                                                      
REMARK 465     ALA I    11                                                      
REMARK 465     LYS I    12                                                      
REMARK 465     ASP I    13                                                      
REMARK 465     SER I    14                                                      
REMARK 465     ASP I    15                                                      
REMARK 465     ASP I    16                                                      
REMARK 465     ASP I    17                                                      
REMARK 465     ASP I    18                                                      
REMARK 465     ASP I    19                                                      
REMARK 465     VAL I    20                                                      
REMARK 465     THR I    21                                                      
REMARK 465     VAL I    22                                                      
REMARK 465     THR I    23                                                      
REMARK 465     VAL I    24                                                      
REMARK 465     ASP I    25                                                      
REMARK 465     ARG I    26                                                      
REMARK 465     ASP I    27                                                      
REMARK 465     ARG I    28                                                      
REMARK 465     PHE I    29                                                      
REMARK 465     MET I    30                                                      
REMARK 465     ASP I    31                                                      
REMARK 465     GLU I    32                                                      
REMARK 465     PHE I    33                                                      
REMARK 465     PHE I    34                                                      
REMARK 465     GLU I    35                                                      
REMARK 465     GLN I    36                                                      
REMARK 465     VAL I    37                                                      
REMARK 465     GLU I    38                                                      
REMARK 465     GLU I    39                                                      
REMARK 465     ILE I    40                                                      
REMARK 465     ARG I    41                                                      
REMARK 465     GLY I    42                                                      
REMARK 465     PHE I    43                                                      
REMARK 465     ILE I    44                                                      
REMARK 465     ASP I    45                                                      
REMARK 465     LYS I    46                                                      
REMARK 465     ILE I    47                                                      
REMARK 465     ALA I    48                                                      
REMARK 465     GLU I    49                                                      
REMARK 465     ASN I    50                                                      
REMARK 465     VAL I    51                                                      
REMARK 465     GLU I    52                                                      
REMARK 465     GLU I    53                                                      
REMARK 465     VAL I    54                                                      
REMARK 465     LYS I    55                                                      
REMARK 465     ARG I    56                                                      
REMARK 465     LYS I    57                                                      
REMARK 465     HIS I    58                                                      
REMARK 465     SER I    59                                                      
REMARK 465     ALA I    60                                                      
REMARK 465     ILE I    61                                                      
REMARK 465     LEU I    62                                                      
REMARK 465     ALA I    63                                                      
REMARK 465     SER I    64                                                      
REMARK 465     PRO I    65                                                      
REMARK 465     ASN I    66                                                      
REMARK 465     PRO I    67                                                      
REMARK 465     ASP I    68                                                      
REMARK 465     GLU I    69                                                      
REMARK 465     LYS I    70                                                      
REMARK 465     THR I    71                                                      
REMARK 465     LYS I    72                                                      
REMARK 465     GLU I    73                                                      
REMARK 465     GLU I    74                                                      
REMARK 465     LEU I    75                                                      
REMARK 465     GLU I    76                                                      
REMARK 465     GLU I    77                                                      
REMARK 465     LEU I    78                                                      
REMARK 465     MET I    79                                                      
REMARK 465     SER I    80                                                      
REMARK 465     ASP I    81                                                      
REMARK 465     ILE I    82                                                      
REMARK 465     LYS I    83                                                      
REMARK 465     LYS I    84                                                      
REMARK 465     THR I    85                                                      
REMARK 465     ALA I    86                                                      
REMARK 465     ASN I    87                                                      
REMARK 465     LYS I    88                                                      
REMARK 465     VAL I    89                                                      
REMARK 465     ARG I    90                                                      
REMARK 465     SER I    91                                                      
REMARK 465     LYS I    92                                                      
REMARK 465     LEU I    93                                                      
REMARK 465     LYS I    94                                                      
REMARK 465     SER I    95                                                      
REMARK 465     ILE I    96                                                      
REMARK 465     GLU I    97                                                      
REMARK 465     GLN I    98                                                      
REMARK 465     SER I    99                                                      
REMARK 465     ILE I   100                                                      
REMARK 465     GLU I   101                                                      
REMARK 465     GLN I   102                                                      
REMARK 465     GLU I   103                                                      
REMARK 465     GLU I   104                                                      
REMARK 465     GLY I   105                                                      
REMARK 465     LEU I   106                                                      
REMARK 465     ASN I   107                                                      
REMARK 465     ARG I   108                                                      
REMARK 465     SER I   109                                                      
REMARK 465     SER I   110                                                      
REMARK 465     ALA I   111                                                      
REMARK 465     ASP I   112                                                      
REMARK 465     LEU I   113                                                      
REMARK 465     ARG I   114                                                      
REMARK 465     ILE I   115                                                      
REMARK 465     ARG I   116                                                      
REMARK 465     LYS I   117                                                      
REMARK 465     THR I   118                                                      
REMARK 465     GLN I   119                                                      
REMARK 465     HIS I   120                                                      
REMARK 465     SER I   121                                                      
REMARK 465     THR I   122                                                      
REMARK 465     LEU I   123                                                      
REMARK 465     SER I   124                                                      
REMARK 465     ARG I   125                                                      
REMARK 465     LYS I   126                                                      
REMARK 465     PHE I   127                                                      
REMARK 465     VAL I   128                                                      
REMARK 465     GLU I   129                                                      
REMARK 465     VAL I   130                                                      
REMARK 465     MET I   131                                                      
REMARK 465     SER I   132                                                      
REMARK 465     GLU I   133                                                      
REMARK 465     TYR I   134                                                      
REMARK 465     ASN I   135                                                      
REMARK 465     ALA I   136                                                      
REMARK 465     THR I   137                                                      
REMARK 465     GLN I   138                                                      
REMARK 465     SER I   139                                                      
REMARK 465     ASP I   140                                                      
REMARK 465     TYR I   141                                                      
REMARK 465     ARG I   142                                                      
REMARK 465     GLU I   143                                                      
REMARK 465     ARG I   144                                                      
REMARK 465     SER I   145                                                      
REMARK 465     LYS I   146                                                      
REMARK 465     GLY I   147                                                      
REMARK 465     ARG I   148                                                      
REMARK 465     ILE I   149                                                      
REMARK 465     GLN I   150                                                      
REMARK 465     ARG I   151                                                      
REMARK 465     GLN I   152                                                      
REMARK 465     LEU I   153                                                      
REMARK 465     GLU I   154                                                      
REMARK 465     ILE I   155                                                      
REMARK 465     THR I   156                                                      
REMARK 465     GLY I   157                                                      
REMARK 465     ARG I   158                                                      
REMARK 465     THR I   159                                                      
REMARK 465     THR I   160                                                      
REMARK 465     THR I   161                                                      
REMARK 465     SER I   162                                                      
REMARK 465     GLU I   163                                                      
REMARK 465     GLU I   164                                                      
REMARK 465     LEU I   165                                                      
REMARK 465     GLU I   166                                                      
REMARK 465     ASP I   167                                                      
REMARK 465     MET I   168                                                      
REMARK 465     LEU I   169                                                      
REMARK 465     GLU I   170                                                      
REMARK 465     SER I   171                                                      
REMARK 465     GLY I   172                                                      
REMARK 465     ASN I   173                                                      
REMARK 465     PRO I   174                                                      
REMARK 465     ALA I   175                                                      
REMARK 465     ILE I   176                                                      
REMARK 465     PHE I   177                                                      
REMARK 465     ALA I   178                                                      
REMARK 465     SER I   179                                                      
REMARK 465     GLY I   180                                                      
REMARK 465     ILE I   181                                                      
REMARK 465     ILE I   182                                                      
REMARK 465     MET I   183                                                      
REMARK 465     ASP I   184                                                      
REMARK 465     SER I   185                                                      
REMARK 465     SER I   186                                                      
REMARK 465     ILE I   187                                                      
REMARK 465     SER I   188                                                      
REMARK 465     LYS I   189                                                      
REMARK 465     GLN I   190                                                      
REMARK 465     MET J   -27                                                      
REMARK 465     ALA J   -26                                                      
REMARK 465     SER J   -25                                                      
REMARK 465     TYR J   -24                                                      
REMARK 465     TYR J   -23                                                      
REMARK 465     HIS J   -22                                                      
REMARK 465     HIS J   -21                                                      
REMARK 465     HIS J   -20                                                      
REMARK 465     HIS J   -19                                                      
REMARK 465     HIS J   -18                                                      
REMARK 465     HIS J   -17                                                      
REMARK 465     ASP J   -16                                                      
REMARK 465     TYR J   -15                                                      
REMARK 465     ASP J   -14                                                      
REMARK 465     ILE J   -13                                                      
REMARK 465     PRO J   -12                                                      
REMARK 465     THR J   -11                                                      
REMARK 465     SER J   -10                                                      
REMARK 465     GLU J    -9                                                      
REMARK 465     ASN J    -8                                                      
REMARK 465     LEU J    -7                                                      
REMARK 465     TYR J    -6                                                      
REMARK 465     PHE J    -5                                                      
REMARK 465     GLN J    -4                                                      
REMARK 465     GLY J    -3                                                      
REMARK 465     ALA J    -2                                                      
REMARK 465     SER J    -1                                                      
REMARK 465     HIS J     0                                                      
REMARK 465     MET J     1                                                      
REMARK 465     SER J     2                                                      
REMARK 465     ALA J     3                                                      
REMARK 465     THR J     4                                                      
REMARK 465     ALA J     5                                                      
REMARK 465     ALA J     6                                                      
REMARK 465     THR J     7                                                      
REMARK 465     VAL J     8                                                      
REMARK 465     PRO J     9                                                      
REMARK 465     PRO J    10                                                      
REMARK 465     ALA J    11                                                      
REMARK 465     ALA J    12                                                      
REMARK 465     PRO J    13                                                      
REMARK 465     ALA J    14                                                      
REMARK 465     GLY J    15                                                      
REMARK 465     GLU J    16                                                      
REMARK 465     GLY J    17                                                      
REMARK 465     GLY J    18                                                      
REMARK 465     PRO J    19                                                      
REMARK 465     PRO J    20                                                      
REMARK 465     ALA J    21                                                      
REMARK 465     PRO J    22                                                      
REMARK 465     PRO J    23                                                      
REMARK 465     PRO J    24                                                      
REMARK 465     ASN J    25                                                      
REMARK 465     LEU J    26                                                      
REMARK 465     THR J    27                                                      
REMARK 465     SER J    28                                                      
REMARK 465     MET K   -17                                                      
REMARK 465     HIS K   -16                                                      
REMARK 465     HIS K   -15                                                      
REMARK 465     HIS K   -14                                                      
REMARK 465     HIS K   -13                                                      
REMARK 465     HIS K   -12                                                      
REMARK 465     HIS K   -11                                                      
REMARK 465     HIS K   -10                                                      
REMARK 465     HIS K    -9                                                      
REMARK 465     HIS K    -8                                                      
REMARK 465     HIS K    -7                                                      
REMARK 465     GLU K    -6                                                      
REMARK 465     ASN K    -5                                                      
REMARK 465     LEU K    -4                                                      
REMARK 465     TYR K    -3                                                      
REMARK 465     PHE K    -2                                                      
REMARK 465     GLN K    -1                                                      
REMARK 465     GLY K     0                                                      
REMARK 465     MET K     1                                                      
REMARK 465     ASP K     2                                                      
REMARK 465     THR K     3                                                      
REMARK 465     SER K     4                                                      
REMARK 465     GLY K     5                                                      
REMARK 465     LYS K     6                                                      
REMARK 465     GLN K     7                                                      
REMARK 465     LEU K   294                                                      
REMARK 465     ARG K   295                                                      
REMARK 465     MET L   -17                                                      
REMARK 465     HIS L   -16                                                      
REMARK 465     HIS L   -15                                                      
REMARK 465     HIS L   -14                                                      
REMARK 465     HIS L   -13                                                      
REMARK 465     HIS L   -12                                                      
REMARK 465     HIS L   -11                                                      
REMARK 465     HIS L   -10                                                      
REMARK 465     HIS L    -9                                                      
REMARK 465     HIS L    -8                                                      
REMARK 465     HIS L    -7                                                      
REMARK 465     GLU L    -6                                                      
REMARK 465     ASN L    -5                                                      
REMARK 465     LEU L    -4                                                      
REMARK 465     TYR L    -3                                                      
REMARK 465     PHE L    -2                                                      
REMARK 465     GLN L    -1                                                      
REMARK 465     GLY L     0                                                      
REMARK 465     MET L     1                                                      
REMARK 465     ASP L     2                                                      
REMARK 465     THR L     3                                                      
REMARK 465     SER L     4                                                      
REMARK 465     GLY L     5                                                      
REMARK 465     LYS L     6                                                      
REMARK 465     GLN L     7                                                      
REMARK 465     LEU L   294                                                      
REMARK 465     ARG L   295                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     LEU F 223    CG   CD1  CD2                                       
REMARK 470     ARG F 238    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS F 251    CG   CD   CE   NZ                                   
REMARK 470     HIS F 252    CG   ND1  CD2  CE1  NE2                             
REMARK 470     LYS F 254    CG   CD   CE   NZ                                   
REMARK 470     LYS F 266    CG   CD   CE   NZ                                   
REMARK 470     LEU F 269    CG   CD1  CD2                                       
REMARK 470     LYS F 275    CG   CD   CE   NZ                                   
REMARK 470     MET F 276    CG   SD   CE                                        
REMARK 470     LEU F 277    CG   CD1  CD2                                       
REMARK 470     ASN F 278    CG   OD1  ND2                                       
REMARK 470     ARG F 280    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU F 281    CG   CD   OE1  OE2                                  
REMARK 470     LYS F 283    CG   CD   CE   NZ                                   
REMARK 470     GLU F 289    CG   CD   OE1  OE2                                  
REMARK 470     ILE F 290    CG1  CG2  CD1                                       
REMARK 470     LEU F 291    CG   CD1  CD2                                       
REMARK 470     ASN F 292    CG   OD1  ND2                                       
REMARK 470     LYS F 293    CG   CD   CE   NZ                                   
REMARK 470     TYR F 294    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     VAL F 295    CG1  CG2                                            
REMARK 470     GLU F 297    CG   CD   OE1  OE2                                  
REMARK 470     SER F 298    OG                                                  
REMARK 470     ILE F 302    CG1  CG2  CD1                                       
REMARK 470     ILE F 325    CG1  CG2  CD1                                       
REMARK 470     GLU F 329    CG   CD   OE1  OE2                                  
REMARK 470     HIS F 347    CG   ND1  CD2  CE1  NE2                             
REMARK 470     ASP F 348    CG   OD1  OD2                                       
REMARK 470     ASN F 352    CG   OD1  ND2                                       
REMARK 470     ASP F 359    CG   OD1  OD2                                       
REMARK 470     VAL F 361    CG1  CG2                                            
REMARK 470     GLU F 362    CG   CD   OE1  OE2                                  
REMARK 470     GLN F 363    CG   CD   OE1  NE2                                  
REMARK 470     LEU F 364    CG   CD1  CD2                                       
REMARK 470     ASN F 366    CG   OD1  ND2                                       
REMARK 470     LEU F 383    CG   CD1  CD2                                       
REMARK 470     GLU F 390    CG   CD   OE1  OE2                                  
REMARK 470     LYS H  83    CG   CD   CE   NZ                                   
REMARK 470     GLN J  71    CG   CD   OE1  NE2                                  
REMARK 470     LYS K 222    CG   CD   CE   NZ                                   
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   H    ALA B    22     O    THR B    48              1.57            
REMARK 500  HH22  ARG E   607     O    TYR E   611              1.58            
REMARK 500   O    ASP L   267    HH11  ARG L   271              1.58            
REMARK 500   O    TYR A   499     H    ILE A   503              1.59            
REMARK 500   OD1  ASP A   229    HH21  ARG A   233              1.59            
REMARK 500   HZ2  LYS F   708     O3A  ATP F   801              1.59            
REMARK 500   O    GLY L    34     H    ILE L    38              1.59            
REMARK 500   O    SER A   538     OG   SER A   662              1.94            
REMARK 500   O    SER D   538     OG   SER D   662              1.95            
REMARK 500   O    ALA H    42     OG1  THR H    46              1.95            
REMARK 500   O    ASP C   512     OG1  THR C   515              1.99            
REMARK 500   O    SER F   538     OG   SER F   662              2.01            
REMARK 500   OG1  THR C   550     O1A  ATP C   801              2.02            
REMARK 500   O    PHE C   564     OG   SER C   598              2.03            
REMARK 500   O    TRP D   510     NE2  GLN D   675              2.04            
REMARK 500   O    SER B   538     OG   SER B   662              2.06            
REMARK 500   O    SER C   538     OG   SER C   662              2.06            
REMARK 500   O    ALA B   557     OG   SER B   560              2.06            
REMARK 500   O    ASP A   688     OG1  THR A   692              2.06            
REMARK 500   O    ILE K   283     OG1  THR K   286              2.07            
REMARK 500   OG   SER D   356     OD2  ASP E   328              2.07            
REMARK 500   NH1  ARG D   403     O    THR D   433              2.07            
REMARK 500   O    GLU L   129     OG1  THR L   133              2.08            
REMARK 500   O    PRO C   544     OG   SER C   547              2.08            
REMARK 500   O    LEU D   718     NH1  ARG D   725              2.09            
REMARK 500   ND2  ASN C   669     O    TRP C   704              2.09            
REMARK 500   OG   SER D   717     O    ARG D   725              2.09            
REMARK 500   O    ALA E   430     OG1  THR E   433              2.10            
REMARK 500   O    MET B   453     ND1  HIS B   456              2.12            
REMARK 500   O    ILE B    92     OG   SER B   181              2.12            
REMARK 500   O    ASN C   106     NZ   LYS C   143              2.12            
REMARK 500   O    LYS F   689     OG1  THR F   692              2.12            
REMARK 500   OE1  GLU C   442     O2'  ATP C   802              2.13            
REMARK 500   O    LYS B   687     NH2  ARG B   691              2.14            
REMARK 500   OE1  GLU B   542     ND1  HIS B   666              2.14            
REMARK 500   OE1  GLU B   681     NH2  ARG B   691              2.15            
REMARK 500   NZ   LYS D   509     O    GLY D   511              2.15            
REMARK 500   O    LYS A   251     NH1  ARG B   446              2.15            
REMARK 500   OE1  GLN A   103     ND2  ASN A   106              2.15            
REMARK 500   OG1  THR B   267     O1A  ATP B   801              2.15            
REMARK 500   NH1  ARG E   403     O    THR E   433              2.15            
REMARK 500   O    ASP L   267     NH1  ARG L   271              2.16            
REMARK 500   N    SER D   320     OD1  ASN D   366              2.17            
REMARK 500   OE1  GLN H    56     NH2  ARG H    59              2.18            
REMARK 500   O    GLU E   690     OG1  THR E   693              2.18            
REMARK 500   OG1  THR A   267     O2A  ADP A   802              2.18            
REMARK 500   O    ILE B   196     NZ   LYS B   200              2.19            
REMARK 500   NE2  HIS C   410     OE2  GLU C   442              2.19            
REMARK 500   NH2  ARG E   607     O    TYR E   611              2.19            
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500    LEU A 481   CB  -  CG  -  CD1 ANGL. DEV. =  10.2 DEGREES          
REMARK 500    ASP A 610   CB  -  CG  -  OD1 ANGL. DEV. =   6.0 DEGREES          
REMARK 500    GLY A 615   N   -  CA  -  C   ANGL. DEV. = -15.6 DEGREES          
REMARK 500    LYS B 200   CD  -  CE  -  NZ  ANGL. DEV. = -16.6 DEGREES          
REMARK 500    VAL B 346   CA  -  CB  -  CG2 ANGL. DEV. =  10.4 DEGREES          
REMARK 500    ARG B 403   NE  -  CZ  -  NH1 ANGL. DEV. =   3.1 DEGREES          
REMARK 500    LEU B 420   CB  -  CG  -  CD2 ANGL. DEV. =  16.3 DEGREES          
REMARK 500    LEU C 444   CA  -  CB  -  CG  ANGL. DEV. =  14.0 DEGREES          
REMARK 500    LEU C 484   CB  -  CG  -  CD2 ANGL. DEV. =  15.3 DEGREES          
REMARK 500    PHE D 306   CB  -  CG  -  CD1 ANGL. DEV. =   4.2 DEGREES          
REMARK 500    GLY D 615   N   -  CA  -  C   ANGL. DEV. = -15.8 DEGREES          
REMARK 500    LEU D 730   CA  -  CB  -  CG  ANGL. DEV. =  16.7 DEGREES          
REMARK 500    ASP E 610   CB  -  CG  -  OD1 ANGL. DEV. =   7.0 DEGREES          
REMARK 500    GLY E 615   N   -  CA  -  C   ANGL. DEV. = -18.4 DEGREES          
REMARK 500    ASP F 591   CB  -  CG  -  OD1 ANGL. DEV. =   5.9 DEGREES          
REMARK 500    GLY F 615   N   -  CA  -  C   ANGL. DEV. = -15.6 DEGREES          
REMARK 500    VAL F 698   CG1 -  CB  -  CG2 ANGL. DEV. =  11.4 DEGREES          
REMARK 500    GLN K  67   CA  -  CB  -  CG  ANGL. DEV. =  13.5 DEGREES          
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    TYR A  29     -168.39   -113.12                                   
REMARK 500    PRO A  53       23.83    -64.91                                   
REMARK 500    ALA A  88      -69.06   -137.30                                   
REMARK 500    ASN A 106       11.63   -146.43                                   
REMARK 500    ASN A 180       51.10    -93.53                                   
REMARK 500    PRO B  12      -76.04    -53.83                                   
REMARK 500    PRO B  41       -4.52    -56.64                                   
REMARK 500    ASP B 100      140.98   -172.17                                   
REMARK 500    PHE B 125       47.35   -102.30                                   
REMARK 500    ASN B 190       39.54     37.53                                   
REMARK 500    ASP B 423       43.84     31.94                                   
REMARK 500    ASP B 688      -69.21   -141.69                                   
REMARK 500    ALA C   9     -164.51   -118.44                                   
REMARK 500    ALA C  22       94.26    -65.17                                   
REMARK 500    PRO C  53       12.04    -61.93                                   
REMARK 500    ILE C  74       98.98    -69.15                                   
REMARK 500    ASN C 106       30.76   -143.09                                   
REMARK 500    ASN C 180       41.61    -98.00                                   
REMARK 500    PHE C 215       75.36   -152.95                                   
REMARK 500    THR C 534       62.96   -151.88                                   
REMARK 500    ASP C 688       32.95     26.51                                   
REMARK 500    THR D  13     -166.48   -119.18                                   
REMARK 500    ASN D  42       12.67   -141.56                                   
REMARK 500    PRO D  53        3.47    -58.38                                   
REMARK 500    SER D  59      138.38   -170.50                                   
REMARK 500    LYS D  87       44.82    -70.73                                   
REMARK 500    LYS D  89        2.71   -150.41                                   
REMARK 500    VAL D 178     -169.33   -125.90                                   
REMARK 500    SER D 191     -152.94    -81.15                                   
REMARK 500    ALA D 199       47.17    -80.56                                   
REMARK 500    ARG D 280      165.55    175.59                                   
REMARK 500    ARG D 315      -73.16    -56.88                                   
REMARK 500    GLU E 289      -16.82    -48.26                                   
REMARK 500    TYR F 294       -1.51     82.35                                   
REMARK 500    SER F 298        7.80     87.55                                   
REMARK 500    ASN F 366       11.71     87.68                                   
REMARK 500    THR F 451      -74.33    -40.47                                   
REMARK 500    THR F 534       64.74   -150.63                                   
REMARK 500    GLN F 636      -61.01   -103.48                                   
REMARK 500    ARG H  16       19.11     81.57                                   
REMARK 500    LEU H  21      -29.90    -36.61                                   
REMARK 500    ARG H 142      -25.63   -151.56                                   
REMARK 500    TYR J  88       40.25   -102.16                                   
REMARK 500    SER K  26     -165.73   -172.87                                   
REMARK 500    LEU K  31      -60.12    -95.26                                   
REMARK 500    LEU K  75      -80.27    -78.14                                   
REMARK 500    GLN K  76       97.77   -166.67                                   
REMARK 500    GLN K  98     -158.14    -79.17                                   
REMARK 500    GLU K  99      -12.38     81.03                                   
REMARK 500    PHE K 117      -39.45   -130.33                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS      65 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS                                         
REMARK 500                                                                      
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH          
REMARK 500 CIS AND TRANS CONFORMATION.  CIS BONDS, IF ANY, ARE LISTED           
REMARK 500 ON CISPEP RECORDS.  TRANS IS DEFINED AS 180 +/- 30 AND               
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.                                  
REMARK 500                                 MODEL     OMEGA                      
REMARK 500 MET H   32     LEU H   33                  148.92                    
REMARK 500 LEU K   75     GLN K   76                  142.83                    
REMARK 500 HIS K  213     PHE K  214                 -149.38                    
REMARK 500 PHE K  214     CYS K  215                 -148.95                    
REMARK 500 LEU L  135     VAL L  136                 -149.56                    
REMARK 500 PHE L  206     PHE L  207                  143.18                    
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: PLANAR GROUPS                                              
REMARK 500                                                                      
REMARK 500 PLANAR GROUPS IN THE FOLLOWING RESIDUES HAVE A TOTAL                 
REMARK 500 RMS DISTANCE OF ALL ATOMS FROM THE BEST-FIT PLANE                    
REMARK 500 BY MORE THAN AN EXPECTED VALUE OF 6*RMSD, WITH AN                    
REMARK 500 RMSD 0.02 ANGSTROMS, OR AT LEAST ONE ATOM HAS                        
REMARK 500 AN RMSD GREATER THAN THIS VALUE                                      
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        RMS     TYPE                                    
REMARK 500    GLN B 405         0.08    SIDE CHAIN                              
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 800                                                                      
REMARK 800 SITE                                                                 
REMARK 800 SITE_IDENTIFIER: AC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ATP A 801                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ADP A 802                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ATP B 801                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ATP B 802                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ATP C 801                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ATP C 802                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC7                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ATP D 801                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC8                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ATP D 802                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC9                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ATP E 801                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ADP E 802                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AD2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ATP F 801                 
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: EMD-9100   RELATED DB: EMDB                              
REMARK 900 THE 20S SUPERCOMPLEX ENGAGING THE SNAP-25 N-TERMINUS (CLASS 1)       
DBREF  6MDM A    1   744  UNP    P18708   NSF_CRIGR        1    744             
DBREF  6MDM B    1   744  UNP    P18708   NSF_CRIGR        1    744             
DBREF  6MDM C    1   744  UNP    P18708   NSF_CRIGR        1    744             
DBREF  6MDM D    1   744  UNP    P18708   NSF_CRIGR        1    744             
DBREF  6MDM E    1   744  UNP    P18708   NSF_CRIGR        1    744             
DBREF  6MDM F    1   744  UNP    P18708   NSF_CRIGR        1    744             
DBREF  6MDM H    1   204  UNP    P60881   SNP25_RAT        1    204             
DBREF  6MDM I    1   256  UNP    P32851   STX1A_RAT        1    256             
DBREF  6MDM J    1    89  UNP    P63045   VAMP2_RAT        1     89             
DBREF  6MDM K    1   295  UNP    P54921   SNAA_RAT         1    295             
DBREF  6MDM L    1   295  UNP    P54921   SNAA_RAT         1    295             
SEQADV 6MDM MET A  -23  UNP  P18708              INITIATING METHIONINE          
SEQADV 6MDM GLY A  -22  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM HIS A  -21  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM HIS A  -20  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM HIS A  -19  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM HIS A  -18  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM HIS A  -17  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM HIS A  -16  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM ASP A  -15  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM TYR A  -14  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM ASP A  -13  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM ILE A  -12  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM PRO A  -11  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM THR A  -10  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM THR A   -9  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM GLU A   -8  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM ASN A   -7  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM LEU A   -6  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM TYR A   -5  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM PHE A   -4  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM GLN A   -3  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM GLY A   -2  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM ALA A   -1  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM HIS A    0  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM ILE A  458  UNP  P18708    LYS   458 CONFLICT                       
SEQADV 6MDM MET B  -23  UNP  P18708              INITIATING METHIONINE          
SEQADV 6MDM GLY B  -22  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM HIS B  -21  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM HIS B  -20  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM HIS B  -19  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM HIS B  -18  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM HIS B  -17  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM HIS B  -16  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM ASP B  -15  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM TYR B  -14  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM ASP B  -13  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM ILE B  -12  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM PRO B  -11  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM THR B  -10  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM THR B   -9  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM GLU B   -8  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM ASN B   -7  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM LEU B   -6  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM TYR B   -5  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM PHE B   -4  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM GLN B   -3  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM GLY B   -2  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM ALA B   -1  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM HIS B    0  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM ILE B  458  UNP  P18708    LYS   458 CONFLICT                       
SEQADV 6MDM MET C  -23  UNP  P18708              INITIATING METHIONINE          
SEQADV 6MDM GLY C  -22  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM HIS C  -21  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM HIS C  -20  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM HIS C  -19  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM HIS C  -18  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM HIS C  -17  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM HIS C  -16  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM ASP C  -15  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM TYR C  -14  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM ASP C  -13  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM ILE C  -12  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM PRO C  -11  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM THR C  -10  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM THR C   -9  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM GLU C   -8  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM ASN C   -7  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM LEU C   -6  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM TYR C   -5  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM PHE C   -4  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM GLN C   -3  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM GLY C   -2  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM ALA C   -1  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM HIS C    0  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM ILE C  458  UNP  P18708    LYS   458 CONFLICT                       
SEQADV 6MDM MET D  -23  UNP  P18708              INITIATING METHIONINE          
SEQADV 6MDM GLY D  -22  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM HIS D  -21  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM HIS D  -20  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM HIS D  -19  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM HIS D  -18  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM HIS D  -17  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM HIS D  -16  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM ASP D  -15  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM TYR D  -14  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM ASP D  -13  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM ILE D  -12  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM PRO D  -11  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM THR D  -10  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM THR D   -9  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM GLU D   -8  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM ASN D   -7  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM LEU D   -6  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM TYR D   -5  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM PHE D   -4  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM GLN D   -3  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM GLY D   -2  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM ALA D   -1  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM HIS D    0  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM ILE D  458  UNP  P18708    LYS   458 CONFLICT                       
SEQADV 6MDM MET E  -23  UNP  P18708              INITIATING METHIONINE          
SEQADV 6MDM GLY E  -22  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM HIS E  -21  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM HIS E  -20  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM HIS E  -19  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM HIS E  -18  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM HIS E  -17  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM HIS E  -16  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM ASP E  -15  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM TYR E  -14  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM ASP E  -13  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM ILE E  -12  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM PRO E  -11  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM THR E  -10  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM THR E   -9  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM GLU E   -8  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM ASN E   -7  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM LEU E   -6  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM TYR E   -5  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM PHE E   -4  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM GLN E   -3  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM GLY E   -2  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM ALA E   -1  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM HIS E    0  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM ILE E  458  UNP  P18708    LYS   458 CONFLICT                       
SEQADV 6MDM MET F  -23  UNP  P18708              INITIATING METHIONINE          
SEQADV 6MDM GLY F  -22  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM HIS F  -21  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM HIS F  -20  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM HIS F  -19  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM HIS F  -18  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM HIS F  -17  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM HIS F  -16  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM ASP F  -15  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM TYR F  -14  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM ASP F  -13  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM ILE F  -12  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM PRO F  -11  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM THR F  -10  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM THR F   -9  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM GLU F   -8  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM ASN F   -7  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM LEU F   -6  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM TYR F   -5  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM PHE F   -4  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM GLN F   -3  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM GLY F   -2  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM ALA F   -1  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM HIS F    0  UNP  P18708              EXPRESSION TAG                 
SEQADV 6MDM ILE F  458  UNP  P18708    LYS   458 CONFLICT                       
SEQADV 6MDM MET H   -2  UNP  P60881              INITIATING METHIONINE          
SEQADV 6MDM ALA H   -1  UNP  P60881              EXPRESSION TAG                 
SEQADV 6MDM SER H    0  UNP  P60881              EXPRESSION TAG                 
SEQADV 6MDM SER I  145  UNP  P32851    CYS   145 CONFLICT                       
SEQADV 6MDM MET J  -27  UNP  P63045              INITIATING METHIONINE          
SEQADV 6MDM ALA J  -26  UNP  P63045              EXPRESSION TAG                 
SEQADV 6MDM SER J  -25  UNP  P63045              EXPRESSION TAG                 
SEQADV 6MDM TYR J  -24  UNP  P63045              EXPRESSION TAG                 
SEQADV 6MDM TYR J  -23  UNP  P63045              EXPRESSION TAG                 
SEQADV 6MDM HIS J  -22  UNP  P63045              EXPRESSION TAG                 
SEQADV 6MDM HIS J  -21  UNP  P63045              EXPRESSION TAG                 
SEQADV 6MDM HIS J  -20  UNP  P63045              EXPRESSION TAG                 
SEQADV 6MDM HIS J  -19  UNP  P63045              EXPRESSION TAG                 
SEQADV 6MDM HIS J  -18  UNP  P63045              EXPRESSION TAG                 
SEQADV 6MDM HIS J  -17  UNP  P63045              EXPRESSION TAG                 
SEQADV 6MDM ASP J  -16  UNP  P63045              EXPRESSION TAG                 
SEQADV 6MDM TYR J  -15  UNP  P63045              EXPRESSION TAG                 
SEQADV 6MDM ASP J  -14  UNP  P63045              EXPRESSION TAG                 
SEQADV 6MDM ILE J  -13  UNP  P63045              EXPRESSION TAG                 
SEQADV 6MDM PRO J  -12  UNP  P63045              EXPRESSION TAG                 
SEQADV 6MDM THR J  -11  UNP  P63045              EXPRESSION TAG                 
SEQADV 6MDM SER J  -10  UNP  P63045              EXPRESSION TAG                 
SEQADV 6MDM GLU J   -9  UNP  P63045              EXPRESSION TAG                 
SEQADV 6MDM ASN J   -8  UNP  P63045              EXPRESSION TAG                 
SEQADV 6MDM LEU J   -7  UNP  P63045              EXPRESSION TAG                 
SEQADV 6MDM TYR J   -6  UNP  P63045              EXPRESSION TAG                 
SEQADV 6MDM PHE J   -5  UNP  P63045              EXPRESSION TAG                 
SEQADV 6MDM GLN J   -4  UNP  P63045              EXPRESSION TAG                 
SEQADV 6MDM GLY J   -3  UNP  P63045              EXPRESSION TAG                 
SEQADV 6MDM ALA J   -2  UNP  P63045              EXPRESSION TAG                 
SEQADV 6MDM SER J   -1  UNP  P63045              EXPRESSION TAG                 
SEQADV 6MDM HIS J    0  UNP  P63045              EXPRESSION TAG                 
SEQADV 6MDM MET K  -17  UNP  P54921              INITIATING METHIONINE          
SEQADV 6MDM HIS K  -16  UNP  P54921              EXPRESSION TAG                 
SEQADV 6MDM HIS K  -15  UNP  P54921              EXPRESSION TAG                 
SEQADV 6MDM HIS K  -14  UNP  P54921              EXPRESSION TAG                 
SEQADV 6MDM HIS K  -13  UNP  P54921              EXPRESSION TAG                 
SEQADV 6MDM HIS K  -12  UNP  P54921              EXPRESSION TAG                 
SEQADV 6MDM HIS K  -11  UNP  P54921              EXPRESSION TAG                 
SEQADV 6MDM HIS K  -10  UNP  P54921              EXPRESSION TAG                 
SEQADV 6MDM HIS K   -9  UNP  P54921              EXPRESSION TAG                 
SEQADV 6MDM HIS K   -8  UNP  P54921              EXPRESSION TAG                 
SEQADV 6MDM HIS K   -7  UNP  P54921              EXPRESSION TAG                 
SEQADV 6MDM GLU K   -6  UNP  P54921              EXPRESSION TAG                 
SEQADV 6MDM ASN K   -5  UNP  P54921              EXPRESSION TAG                 
SEQADV 6MDM LEU K   -4  UNP  P54921              EXPRESSION TAG                 
SEQADV 6MDM TYR K   -3  UNP  P54921              EXPRESSION TAG                 
SEQADV 6MDM PHE K   -2  UNP  P54921              EXPRESSION TAG                 
SEQADV 6MDM GLN K   -1  UNP  P54921              EXPRESSION TAG                 
SEQADV 6MDM GLY K    0  UNP  P54921              EXPRESSION TAG                 
SEQADV 6MDM MET L  -17  UNP  P54921              INITIATING METHIONINE          
SEQADV 6MDM HIS L  -16  UNP  P54921              EXPRESSION TAG                 
SEQADV 6MDM HIS L  -15  UNP  P54921              EXPRESSION TAG                 
SEQADV 6MDM HIS L  -14  UNP  P54921              EXPRESSION TAG                 
SEQADV 6MDM HIS L  -13  UNP  P54921              EXPRESSION TAG                 
SEQADV 6MDM HIS L  -12  UNP  P54921              EXPRESSION TAG                 
SEQADV 6MDM HIS L  -11  UNP  P54921              EXPRESSION TAG                 
SEQADV 6MDM HIS L  -10  UNP  P54921              EXPRESSION TAG                 
SEQADV 6MDM HIS L   -9  UNP  P54921              EXPRESSION TAG                 
SEQADV 6MDM HIS L   -8  UNP  P54921              EXPRESSION TAG                 
SEQADV 6MDM HIS L   -7  UNP  P54921              EXPRESSION TAG                 
SEQADV 6MDM GLU L   -6  UNP  P54921              EXPRESSION TAG                 
SEQADV 6MDM ASN L   -5  UNP  P54921              EXPRESSION TAG                 
SEQADV 6MDM LEU L   -4  UNP  P54921              EXPRESSION TAG                 
SEQADV 6MDM TYR L   -3  UNP  P54921              EXPRESSION TAG                 
SEQADV 6MDM PHE L   -2  UNP  P54921              EXPRESSION TAG                 
SEQADV 6MDM GLN L   -1  UNP  P54921              EXPRESSION TAG                 
SEQADV 6MDM GLY L    0  UNP  P54921              EXPRESSION TAG                 
SEQRES   1 A  768  MET GLY HIS HIS HIS HIS HIS HIS ASP TYR ASP ILE PRO          
SEQRES   2 A  768  THR THR GLU ASN LEU TYR PHE GLN GLY ALA HIS MET ALA          
SEQRES   3 A  768  GLY ARG SER MET GLN ALA ALA ARG CYS PRO THR ASP GLU          
SEQRES   4 A  768  LEU SER LEU SER ASN CYS ALA VAL VAL SER GLU LYS ASP          
SEQRES   5 A  768  TYR GLN SER GLY GLN HIS VAL ILE VAL ARG THR SER PRO          
SEQRES   6 A  768  ASN HIS LYS TYR ILE PHE THR LEU ARG THR HIS PRO SER          
SEQRES   7 A  768  VAL VAL PRO GLY SER VAL ALA PHE SER LEU PRO GLN ARG          
SEQRES   8 A  768  LYS TRP ALA GLY LEU SER ILE GLY GLN GLU ILE GLU VAL          
SEQRES   9 A  768  ALA LEU TYR SER PHE ASP LYS ALA LYS GLN CYS ILE GLY          
SEQRES  10 A  768  THR MET THR ILE GLU ILE ASP PHE LEU GLN LYS LYS ASN          
SEQRES  11 A  768  ILE ASP SER ASN PRO TYR ASP THR ASP LYS MET ALA ALA          
SEQRES  12 A  768  GLU PHE ILE GLN GLN PHE ASN ASN GLN ALA PHE SER VAL          
SEQRES  13 A  768  GLY GLN GLN LEU VAL PHE SER PHE ASN ASP LYS LEU PHE          
SEQRES  14 A  768  GLY LEU LEU VAL LYS ASP ILE GLU ALA MET ASP PRO SER          
SEQRES  15 A  768  ILE LEU LYS GLY GLU PRO ALA SER GLY LYS ARG GLN LYS          
SEQRES  16 A  768  ILE GLU VAL GLY LEU VAL VAL GLY ASN SER GLN VAL ALA          
SEQRES  17 A  768  PHE GLU LYS ALA GLU ASN SER SER LEU ASN LEU ILE GLY          
SEQRES  18 A  768  LYS ALA LYS THR LYS GLU ASN ARG GLN SER ILE ILE ASN          
SEQRES  19 A  768  PRO ASP TRP ASN PHE GLU LYS MET GLY ILE GLY GLY LEU          
SEQRES  20 A  768  ASP LYS GLU PHE SER ASP ILE PHE ARG ARG ALA PHE ALA          
SEQRES  21 A  768  SER ARG VAL PHE PRO PRO GLU ILE VAL GLU GLN MET GLY          
SEQRES  22 A  768  CYS LYS HIS VAL LYS GLY ILE LEU LEU TYR GLY PRO PRO          
SEQRES  23 A  768  GLY CYS GLY LYS THR LEU LEU ALA ARG GLN ILE GLY LYS          
SEQRES  24 A  768  MET LEU ASN ALA ARG GLU PRO LYS VAL VAL ASN GLY PRO          
SEQRES  25 A  768  GLU ILE LEU ASN LYS TYR VAL GLY GLU SER GLU ALA ASN          
SEQRES  26 A  768  ILE ARG LYS LEU PHE ALA ASP ALA GLU GLU GLU GLN ARG          
SEQRES  27 A  768  ARG LEU GLY ALA ASN SER GLY LEU HIS ILE ILE ILE PHE          
SEQRES  28 A  768  ASP GLU ILE ASP ALA ILE CYS LYS GLN ARG GLY SER MET          
SEQRES  29 A  768  ALA GLY SER THR GLY VAL HIS ASP THR VAL VAL ASN GLN          
SEQRES  30 A  768  LEU LEU SER LYS ILE ASP GLY VAL GLU GLN LEU ASN ASN          
SEQRES  31 A  768  ILE LEU VAL ILE GLY MET THR ASN ARG PRO ASP LEU ILE          
SEQRES  32 A  768  ASP GLU ALA LEU LEU ARG PRO GLY ARG LEU GLU VAL LYS          
SEQRES  33 A  768  MET GLU ILE GLY LEU PRO ASP GLU LYS GLY ARG LEU GLN          
SEQRES  34 A  768  ILE LEU HIS ILE HIS THR ALA ARG MET ARG GLY HIS GLN          
SEQRES  35 A  768  LEU LEU SER ALA ASP VAL ASP ILE LYS GLU LEU ALA VAL          
SEQRES  36 A  768  GLU THR LYS ASN PHE SER GLY ALA GLU LEU GLU GLY LEU          
SEQRES  37 A  768  VAL ARG ALA ALA GLN SER THR ALA MET ASN ARG HIS ILE          
SEQRES  38 A  768  ILE ALA SER THR LYS VAL GLU VAL ASP MET GLU LYS ALA          
SEQRES  39 A  768  GLU SER LEU GLN VAL THR ARG GLY ASP PHE LEU ALA SER          
SEQRES  40 A  768  LEU GLU ASN ASP ILE LYS PRO ALA PHE GLY THR ASN GLN          
SEQRES  41 A  768  GLU ASP TYR ALA SER TYR ILE MET ASN GLY ILE ILE LYS          
SEQRES  42 A  768  TRP GLY ASP PRO VAL THR ARG VAL LEU ASP ASP GLY GLU          
SEQRES  43 A  768  LEU LEU VAL GLN GLN THR LYS ASN SER ASP ARG THR PRO          
SEQRES  44 A  768  LEU VAL SER VAL LEU LEU GLU GLY PRO PRO HIS SER GLY          
SEQRES  45 A  768  LYS THR ALA LEU ALA ALA LYS ILE ALA GLU GLU SER ASN          
SEQRES  46 A  768  PHE PRO PHE ILE LYS ILE CYS SER PRO ASP LYS MET ILE          
SEQRES  47 A  768  GLY PHE SER GLU THR ALA LYS CYS GLN ALA MET LYS LYS          
SEQRES  48 A  768  ILE PHE ASP ASP ALA TYR LYS SER GLN LEU SER CYS VAL          
SEQRES  49 A  768  VAL VAL ASP ASP ILE GLU ARG LEU LEU ASP TYR VAL PRO          
SEQRES  50 A  768  ILE GLY PRO ARG PHE SER ASN LEU VAL LEU GLN ALA LEU          
SEQRES  51 A  768  LEU VAL LEU LEU LYS LYS ALA PRO PRO GLN GLY ARG LYS          
SEQRES  52 A  768  LEU LEU ILE ILE GLY THR THR SER ARG LYS ASP VAL LEU          
SEQRES  53 A  768  GLN GLU MET GLU MET LEU ASN ALA PHE SER THR THR ILE          
SEQRES  54 A  768  HIS VAL PRO ASN ILE ALA THR GLY GLU GLN LEU LEU GLU          
SEQRES  55 A  768  ALA LEU GLU LEU LEU GLY ASN PHE LYS ASP LYS GLU ARG          
SEQRES  56 A  768  THR THR ILE ALA GLN GLN VAL LYS GLY LYS LYS VAL TRP          
SEQRES  57 A  768  ILE GLY ILE LYS LYS LEU LEU MET LEU ILE GLU MET SER          
SEQRES  58 A  768  LEU GLN MET ASP PRO GLU TYR ARG VAL ARG LYS PHE LEU          
SEQRES  59 A  768  ALA LEU LEU ARG GLU GLU GLY ALA SER PRO LEU ASP PHE          
SEQRES  60 A  768  ASP                                                          
SEQRES   1 B  768  MET GLY HIS HIS HIS HIS HIS HIS ASP TYR ASP ILE PRO          
SEQRES   2 B  768  THR THR GLU ASN LEU TYR PHE GLN GLY ALA HIS MET ALA          
SEQRES   3 B  768  GLY ARG SER MET GLN ALA ALA ARG CYS PRO THR ASP GLU          
SEQRES   4 B  768  LEU SER LEU SER ASN CYS ALA VAL VAL SER GLU LYS ASP          
SEQRES   5 B  768  TYR GLN SER GLY GLN HIS VAL ILE VAL ARG THR SER PRO          
SEQRES   6 B  768  ASN HIS LYS TYR ILE PHE THR LEU ARG THR HIS PRO SER          
SEQRES   7 B  768  VAL VAL PRO GLY SER VAL ALA PHE SER LEU PRO GLN ARG          
SEQRES   8 B  768  LYS TRP ALA GLY LEU SER ILE GLY GLN GLU ILE GLU VAL          
SEQRES   9 B  768  ALA LEU TYR SER PHE ASP LYS ALA LYS GLN CYS ILE GLY          
SEQRES  10 B  768  THR MET THR ILE GLU ILE ASP PHE LEU GLN LYS LYS ASN          
SEQRES  11 B  768  ILE ASP SER ASN PRO TYR ASP THR ASP LYS MET ALA ALA          
SEQRES  12 B  768  GLU PHE ILE GLN GLN PHE ASN ASN GLN ALA PHE SER VAL          
SEQRES  13 B  768  GLY GLN GLN LEU VAL PHE SER PHE ASN ASP LYS LEU PHE          
SEQRES  14 B  768  GLY LEU LEU VAL LYS ASP ILE GLU ALA MET ASP PRO SER          
SEQRES  15 B  768  ILE LEU LYS GLY GLU PRO ALA SER GLY LYS ARG GLN LYS          
SEQRES  16 B  768  ILE GLU VAL GLY LEU VAL VAL GLY ASN SER GLN VAL ALA          
SEQRES  17 B  768  PHE GLU LYS ALA GLU ASN SER SER LEU ASN LEU ILE GLY          
SEQRES  18 B  768  LYS ALA LYS THR LYS GLU ASN ARG GLN SER ILE ILE ASN          
SEQRES  19 B  768  PRO ASP TRP ASN PHE GLU LYS MET GLY ILE GLY GLY LEU          
SEQRES  20 B  768  ASP LYS GLU PHE SER ASP ILE PHE ARG ARG ALA PHE ALA          
SEQRES  21 B  768  SER ARG VAL PHE PRO PRO GLU ILE VAL GLU GLN MET GLY          
SEQRES  22 B  768  CYS LYS HIS VAL LYS GLY ILE LEU LEU TYR GLY PRO PRO          
SEQRES  23 B  768  GLY CYS GLY LYS THR LEU LEU ALA ARG GLN ILE GLY LYS          
SEQRES  24 B  768  MET LEU ASN ALA ARG GLU PRO LYS VAL VAL ASN GLY PRO          
SEQRES  25 B  768  GLU ILE LEU ASN LYS TYR VAL GLY GLU SER GLU ALA ASN          
SEQRES  26 B  768  ILE ARG LYS LEU PHE ALA ASP ALA GLU GLU GLU GLN ARG          
SEQRES  27 B  768  ARG LEU GLY ALA ASN SER GLY LEU HIS ILE ILE ILE PHE          
SEQRES  28 B  768  ASP GLU ILE ASP ALA ILE CYS LYS GLN ARG GLY SER MET          
SEQRES  29 B  768  ALA GLY SER THR GLY VAL HIS ASP THR VAL VAL ASN GLN          
SEQRES  30 B  768  LEU LEU SER LYS ILE ASP GLY VAL GLU GLN LEU ASN ASN          
SEQRES  31 B  768  ILE LEU VAL ILE GLY MET THR ASN ARG PRO ASP LEU ILE          
SEQRES  32 B  768  ASP GLU ALA LEU LEU ARG PRO GLY ARG LEU GLU VAL LYS          
SEQRES  33 B  768  MET GLU ILE GLY LEU PRO ASP GLU LYS GLY ARG LEU GLN          
SEQRES  34 B  768  ILE LEU HIS ILE HIS THR ALA ARG MET ARG GLY HIS GLN          
SEQRES  35 B  768  LEU LEU SER ALA ASP VAL ASP ILE LYS GLU LEU ALA VAL          
SEQRES  36 B  768  GLU THR LYS ASN PHE SER GLY ALA GLU LEU GLU GLY LEU          
SEQRES  37 B  768  VAL ARG ALA ALA GLN SER THR ALA MET ASN ARG HIS ILE          
SEQRES  38 B  768  ILE ALA SER THR LYS VAL GLU VAL ASP MET GLU LYS ALA          
SEQRES  39 B  768  GLU SER LEU GLN VAL THR ARG GLY ASP PHE LEU ALA SER          
SEQRES  40 B  768  LEU GLU ASN ASP ILE LYS PRO ALA PHE GLY THR ASN GLN          
SEQRES  41 B  768  GLU ASP TYR ALA SER TYR ILE MET ASN GLY ILE ILE LYS          
SEQRES  42 B  768  TRP GLY ASP PRO VAL THR ARG VAL LEU ASP ASP GLY GLU          
SEQRES  43 B  768  LEU LEU VAL GLN GLN THR LYS ASN SER ASP ARG THR PRO          
SEQRES  44 B  768  LEU VAL SER VAL LEU LEU GLU GLY PRO PRO HIS SER GLY          
SEQRES  45 B  768  LYS THR ALA LEU ALA ALA LYS ILE ALA GLU GLU SER ASN          
SEQRES  46 B  768  PHE PRO PHE ILE LYS ILE CYS SER PRO ASP LYS MET ILE          
SEQRES  47 B  768  GLY PHE SER GLU THR ALA LYS CYS GLN ALA MET LYS LYS          
SEQRES  48 B  768  ILE PHE ASP ASP ALA TYR LYS SER GLN LEU SER CYS VAL          
SEQRES  49 B  768  VAL VAL ASP ASP ILE GLU ARG LEU LEU ASP TYR VAL PRO          
SEQRES  50 B  768  ILE GLY PRO ARG PHE SER ASN LEU VAL LEU GLN ALA LEU          
SEQRES  51 B  768  LEU VAL LEU LEU LYS LYS ALA PRO PRO GLN GLY ARG LYS          
SEQRES  52 B  768  LEU LEU ILE ILE GLY THR THR SER ARG LYS ASP VAL LEU          
SEQRES  53 B  768  GLN GLU MET GLU MET LEU ASN ALA PHE SER THR THR ILE          
SEQRES  54 B  768  HIS VAL PRO ASN ILE ALA THR GLY GLU GLN LEU LEU GLU          
SEQRES  55 B  768  ALA LEU GLU LEU LEU GLY ASN PHE LYS ASP LYS GLU ARG          
SEQRES  56 B  768  THR THR ILE ALA GLN GLN VAL LYS GLY LYS LYS VAL TRP          
SEQRES  57 B  768  ILE GLY ILE LYS LYS LEU LEU MET LEU ILE GLU MET SER          
SEQRES  58 B  768  LEU GLN MET ASP PRO GLU TYR ARG VAL ARG LYS PHE LEU          
SEQRES  59 B  768  ALA LEU LEU ARG GLU GLU GLY ALA SER PRO LEU ASP PHE          
SEQRES  60 B  768  ASP                                                          
SEQRES   1 C  768  MET GLY HIS HIS HIS HIS HIS HIS ASP TYR ASP ILE PRO          
SEQRES   2 C  768  THR THR GLU ASN LEU TYR PHE GLN GLY ALA HIS MET ALA          
SEQRES   3 C  768  GLY ARG SER MET GLN ALA ALA ARG CYS PRO THR ASP GLU          
SEQRES   4 C  768  LEU SER LEU SER ASN CYS ALA VAL VAL SER GLU LYS ASP          
SEQRES   5 C  768  TYR GLN SER GLY GLN HIS VAL ILE VAL ARG THR SER PRO          
SEQRES   6 C  768  ASN HIS LYS TYR ILE PHE THR LEU ARG THR HIS PRO SER          
SEQRES   7 C  768  VAL VAL PRO GLY SER VAL ALA PHE SER LEU PRO GLN ARG          
SEQRES   8 C  768  LYS TRP ALA GLY LEU SER ILE GLY GLN GLU ILE GLU VAL          
SEQRES   9 C  768  ALA LEU TYR SER PHE ASP LYS ALA LYS GLN CYS ILE GLY          
SEQRES  10 C  768  THR MET THR ILE GLU ILE ASP PHE LEU GLN LYS LYS ASN          
SEQRES  11 C  768  ILE ASP SER ASN PRO TYR ASP THR ASP LYS MET ALA ALA          
SEQRES  12 C  768  GLU PHE ILE GLN GLN PHE ASN ASN GLN ALA PHE SER VAL          
SEQRES  13 C  768  GLY GLN GLN LEU VAL PHE SER PHE ASN ASP LYS LEU PHE          
SEQRES  14 C  768  GLY LEU LEU VAL LYS ASP ILE GLU ALA MET ASP PRO SER          
SEQRES  15 C  768  ILE LEU LYS GLY GLU PRO ALA SER GLY LYS ARG GLN LYS          
SEQRES  16 C  768  ILE GLU VAL GLY LEU VAL VAL GLY ASN SER GLN VAL ALA          
SEQRES  17 C  768  PHE GLU LYS ALA GLU ASN SER SER LEU ASN LEU ILE GLY          
SEQRES  18 C  768  LYS ALA LYS THR LYS GLU ASN ARG GLN SER ILE ILE ASN          
SEQRES  19 C  768  PRO ASP TRP ASN PHE GLU LYS MET GLY ILE GLY GLY LEU          
SEQRES  20 C  768  ASP LYS GLU PHE SER ASP ILE PHE ARG ARG ALA PHE ALA          
SEQRES  21 C  768  SER ARG VAL PHE PRO PRO GLU ILE VAL GLU GLN MET GLY          
SEQRES  22 C  768  CYS LYS HIS VAL LYS GLY ILE LEU LEU TYR GLY PRO PRO          
SEQRES  23 C  768  GLY CYS GLY LYS THR LEU LEU ALA ARG GLN ILE GLY LYS          
SEQRES  24 C  768  MET LEU ASN ALA ARG GLU PRO LYS VAL VAL ASN GLY PRO          
SEQRES  25 C  768  GLU ILE LEU ASN LYS TYR VAL GLY GLU SER GLU ALA ASN          
SEQRES  26 C  768  ILE ARG LYS LEU PHE ALA ASP ALA GLU GLU GLU GLN ARG          
SEQRES  27 C  768  ARG LEU GLY ALA ASN SER GLY LEU HIS ILE ILE ILE PHE          
SEQRES  28 C  768  ASP GLU ILE ASP ALA ILE CYS LYS GLN ARG GLY SER MET          
SEQRES  29 C  768  ALA GLY SER THR GLY VAL HIS ASP THR VAL VAL ASN GLN          
SEQRES  30 C  768  LEU LEU SER LYS ILE ASP GLY VAL GLU GLN LEU ASN ASN          
SEQRES  31 C  768  ILE LEU VAL ILE GLY MET THR ASN ARG PRO ASP LEU ILE          
SEQRES  32 C  768  ASP GLU ALA LEU LEU ARG PRO GLY ARG LEU GLU VAL LYS          
SEQRES  33 C  768  MET GLU ILE GLY LEU PRO ASP GLU LYS GLY ARG LEU GLN          
SEQRES  34 C  768  ILE LEU HIS ILE HIS THR ALA ARG MET ARG GLY HIS GLN          
SEQRES  35 C  768  LEU LEU SER ALA ASP VAL ASP ILE LYS GLU LEU ALA VAL          
SEQRES  36 C  768  GLU THR LYS ASN PHE SER GLY ALA GLU LEU GLU GLY LEU          
SEQRES  37 C  768  VAL ARG ALA ALA GLN SER THR ALA MET ASN ARG HIS ILE          
SEQRES  38 C  768  ILE ALA SER THR LYS VAL GLU VAL ASP MET GLU LYS ALA          
SEQRES  39 C  768  GLU SER LEU GLN VAL THR ARG GLY ASP PHE LEU ALA SER          
SEQRES  40 C  768  LEU GLU ASN ASP ILE LYS PRO ALA PHE GLY THR ASN GLN          
SEQRES  41 C  768  GLU ASP TYR ALA SER TYR ILE MET ASN GLY ILE ILE LYS          
SEQRES  42 C  768  TRP GLY ASP PRO VAL THR ARG VAL LEU ASP ASP GLY GLU          
SEQRES  43 C  768  LEU LEU VAL GLN GLN THR LYS ASN SER ASP ARG THR PRO          
SEQRES  44 C  768  LEU VAL SER VAL LEU LEU GLU GLY PRO PRO HIS SER GLY          
SEQRES  45 C  768  LYS THR ALA LEU ALA ALA LYS ILE ALA GLU GLU SER ASN          
SEQRES  46 C  768  PHE PRO PHE ILE LYS ILE CYS SER PRO ASP LYS MET ILE          
SEQRES  47 C  768  GLY PHE SER GLU THR ALA LYS CYS GLN ALA MET LYS LYS          
SEQRES  48 C  768  ILE PHE ASP ASP ALA TYR LYS SER GLN LEU SER CYS VAL          
SEQRES  49 C  768  VAL VAL ASP ASP ILE GLU ARG LEU LEU ASP TYR VAL PRO          
SEQRES  50 C  768  ILE GLY PRO ARG PHE SER ASN LEU VAL LEU GLN ALA LEU          
SEQRES  51 C  768  LEU VAL LEU LEU LYS LYS ALA PRO PRO GLN GLY ARG LYS          
SEQRES  52 C  768  LEU LEU ILE ILE GLY THR THR SER ARG LYS ASP VAL LEU          
SEQRES  53 C  768  GLN GLU MET GLU MET LEU ASN ALA PHE SER THR THR ILE          
SEQRES  54 C  768  HIS VAL PRO ASN ILE ALA THR GLY GLU GLN LEU LEU GLU          
SEQRES  55 C  768  ALA LEU GLU LEU LEU GLY ASN PHE LYS ASP LYS GLU ARG          
SEQRES  56 C  768  THR THR ILE ALA GLN GLN VAL LYS GLY LYS LYS VAL TRP          
SEQRES  57 C  768  ILE GLY ILE LYS LYS LEU LEU MET LEU ILE GLU MET SER          
SEQRES  58 C  768  LEU GLN MET ASP PRO GLU TYR ARG VAL ARG LYS PHE LEU          
SEQRES  59 C  768  ALA LEU LEU ARG GLU GLU GLY ALA SER PRO LEU ASP PHE          
SEQRES  60 C  768  ASP                                                          
SEQRES   1 D  768  MET GLY HIS HIS HIS HIS HIS HIS ASP TYR ASP ILE PRO          
SEQRES   2 D  768  THR THR GLU ASN LEU TYR PHE GLN GLY ALA HIS MET ALA          
SEQRES   3 D  768  GLY ARG SER MET GLN ALA ALA ARG CYS PRO THR ASP GLU          
SEQRES   4 D  768  LEU SER LEU SER ASN CYS ALA VAL VAL SER GLU LYS ASP          
SEQRES   5 D  768  TYR GLN SER GLY GLN HIS VAL ILE VAL ARG THR SER PRO          
SEQRES   6 D  768  ASN HIS LYS TYR ILE PHE THR LEU ARG THR HIS PRO SER          
SEQRES   7 D  768  VAL VAL PRO GLY SER VAL ALA PHE SER LEU PRO GLN ARG          
SEQRES   8 D  768  LYS TRP ALA GLY LEU SER ILE GLY GLN GLU ILE GLU VAL          
SEQRES   9 D  768  ALA LEU TYR SER PHE ASP LYS ALA LYS GLN CYS ILE GLY          
SEQRES  10 D  768  THR MET THR ILE GLU ILE ASP PHE LEU GLN LYS LYS ASN          
SEQRES  11 D  768  ILE ASP SER ASN PRO TYR ASP THR ASP LYS MET ALA ALA          
SEQRES  12 D  768  GLU PHE ILE GLN GLN PHE ASN ASN GLN ALA PHE SER VAL          
SEQRES  13 D  768  GLY GLN GLN LEU VAL PHE SER PHE ASN ASP LYS LEU PHE          
SEQRES  14 D  768  GLY LEU LEU VAL LYS ASP ILE GLU ALA MET ASP PRO SER          
SEQRES  15 D  768  ILE LEU LYS GLY GLU PRO ALA SER GLY LYS ARG GLN LYS          
SEQRES  16 D  768  ILE GLU VAL GLY LEU VAL VAL GLY ASN SER GLN VAL ALA          
SEQRES  17 D  768  PHE GLU LYS ALA GLU ASN SER SER LEU ASN LEU ILE GLY          
SEQRES  18 D  768  LYS ALA LYS THR LYS GLU ASN ARG GLN SER ILE ILE ASN          
SEQRES  19 D  768  PRO ASP TRP ASN PHE GLU LYS MET GLY ILE GLY GLY LEU          
SEQRES  20 D  768  ASP LYS GLU PHE SER ASP ILE PHE ARG ARG ALA PHE ALA          
SEQRES  21 D  768  SER ARG VAL PHE PRO PRO GLU ILE VAL GLU GLN MET GLY          
SEQRES  22 D  768  CYS LYS HIS VAL LYS GLY ILE LEU LEU TYR GLY PRO PRO          
SEQRES  23 D  768  GLY CYS GLY LYS THR LEU LEU ALA ARG GLN ILE GLY LYS          
SEQRES  24 D  768  MET LEU ASN ALA ARG GLU PRO LYS VAL VAL ASN GLY PRO          
SEQRES  25 D  768  GLU ILE LEU ASN LYS TYR VAL GLY GLU SER GLU ALA ASN          
SEQRES  26 D  768  ILE ARG LYS LEU PHE ALA ASP ALA GLU GLU GLU GLN ARG          
SEQRES  27 D  768  ARG LEU GLY ALA ASN SER GLY LEU HIS ILE ILE ILE PHE          
SEQRES  28 D  768  ASP GLU ILE ASP ALA ILE CYS LYS GLN ARG GLY SER MET          
SEQRES  29 D  768  ALA GLY SER THR GLY VAL HIS ASP THR VAL VAL ASN GLN          
SEQRES  30 D  768  LEU LEU SER LYS ILE ASP GLY VAL GLU GLN LEU ASN ASN          
SEQRES  31 D  768  ILE LEU VAL ILE GLY MET THR ASN ARG PRO ASP LEU ILE          
SEQRES  32 D  768  ASP GLU ALA LEU LEU ARG PRO GLY ARG LEU GLU VAL LYS          
SEQRES  33 D  768  MET GLU ILE GLY LEU PRO ASP GLU LYS GLY ARG LEU GLN          
SEQRES  34 D  768  ILE LEU HIS ILE HIS THR ALA ARG MET ARG GLY HIS GLN          
SEQRES  35 D  768  LEU LEU SER ALA ASP VAL ASP ILE LYS GLU LEU ALA VAL          
SEQRES  36 D  768  GLU THR LYS ASN PHE SER GLY ALA GLU LEU GLU GLY LEU          
SEQRES  37 D  768  VAL ARG ALA ALA GLN SER THR ALA MET ASN ARG HIS ILE          
SEQRES  38 D  768  ILE ALA SER THR LYS VAL GLU VAL ASP MET GLU LYS ALA          
SEQRES  39 D  768  GLU SER LEU GLN VAL THR ARG GLY ASP PHE LEU ALA SER          
SEQRES  40 D  768  LEU GLU ASN ASP ILE LYS PRO ALA PHE GLY THR ASN GLN          
SEQRES  41 D  768  GLU ASP TYR ALA SER TYR ILE MET ASN GLY ILE ILE LYS          
SEQRES  42 D  768  TRP GLY ASP PRO VAL THR ARG VAL LEU ASP ASP GLY GLU          
SEQRES  43 D  768  LEU LEU VAL GLN GLN THR LYS ASN SER ASP ARG THR PRO          
SEQRES  44 D  768  LEU VAL SER VAL LEU LEU GLU GLY PRO PRO HIS SER GLY          
SEQRES  45 D  768  LYS THR ALA LEU ALA ALA LYS ILE ALA GLU GLU SER ASN          
SEQRES  46 D  768  PHE PRO PHE ILE LYS ILE CYS SER PRO ASP LYS MET ILE          
SEQRES  47 D  768  GLY PHE SER GLU THR ALA LYS CYS GLN ALA MET LYS LYS          
SEQRES  48 D  768  ILE PHE ASP ASP ALA TYR LYS SER GLN LEU SER CYS VAL          
SEQRES  49 D  768  VAL VAL ASP ASP ILE GLU ARG LEU LEU ASP TYR VAL PRO          
SEQRES  50 D  768  ILE GLY PRO ARG PHE SER ASN LEU VAL LEU GLN ALA LEU          
SEQRES  51 D  768  LEU VAL LEU LEU LYS LYS ALA PRO PRO GLN GLY ARG LYS          
SEQRES  52 D  768  LEU LEU ILE ILE GLY THR THR SER ARG LYS ASP VAL LEU          
SEQRES  53 D  768  GLN GLU MET GLU MET LEU ASN ALA PHE SER THR THR ILE          
SEQRES  54 D  768  HIS VAL PRO ASN ILE ALA THR GLY GLU GLN LEU LEU GLU          
SEQRES  55 D  768  ALA LEU GLU LEU LEU GLY ASN PHE LYS ASP LYS GLU ARG          
SEQRES  56 D  768  THR THR ILE ALA GLN GLN VAL LYS GLY LYS LYS VAL TRP          
SEQRES  57 D  768  ILE GLY ILE LYS LYS LEU LEU MET LEU ILE GLU MET SER          
SEQRES  58 D  768  LEU GLN MET ASP PRO GLU TYR ARG VAL ARG LYS PHE LEU          
SEQRES  59 D  768  ALA LEU LEU ARG GLU GLU GLY ALA SER PRO LEU ASP PHE          
SEQRES  60 D  768  ASP                                                          
SEQRES   1 E  768  MET GLY HIS HIS HIS HIS HIS HIS ASP TYR ASP ILE PRO          
SEQRES   2 E  768  THR THR GLU ASN LEU TYR PHE GLN GLY ALA HIS MET ALA          
SEQRES   3 E  768  GLY ARG SER MET GLN ALA ALA ARG CYS PRO THR ASP GLU          
SEQRES   4 E  768  LEU SER LEU SER ASN CYS ALA VAL VAL SER GLU LYS ASP          
SEQRES   5 E  768  TYR GLN SER GLY GLN HIS VAL ILE VAL ARG THR SER PRO          
SEQRES   6 E  768  ASN HIS LYS TYR ILE PHE THR LEU ARG THR HIS PRO SER          
SEQRES   7 E  768  VAL VAL PRO GLY SER VAL ALA PHE SER LEU PRO GLN ARG          
SEQRES   8 E  768  LYS TRP ALA GLY LEU SER ILE GLY GLN GLU ILE GLU VAL          
SEQRES   9 E  768  ALA LEU TYR SER PHE ASP LYS ALA LYS GLN CYS ILE GLY          
SEQRES  10 E  768  THR MET THR ILE GLU ILE ASP PHE LEU GLN LYS LYS ASN          
SEQRES  11 E  768  ILE ASP SER ASN PRO TYR ASP THR ASP LYS MET ALA ALA          
SEQRES  12 E  768  GLU PHE ILE GLN GLN PHE ASN ASN GLN ALA PHE SER VAL          
SEQRES  13 E  768  GLY GLN GLN LEU VAL PHE SER PHE ASN ASP LYS LEU PHE          
SEQRES  14 E  768  GLY LEU LEU VAL LYS ASP ILE GLU ALA MET ASP PRO SER          
SEQRES  15 E  768  ILE LEU LYS GLY GLU PRO ALA SER GLY LYS ARG GLN LYS          
SEQRES  16 E  768  ILE GLU VAL GLY LEU VAL VAL GLY ASN SER GLN VAL ALA          
SEQRES  17 E  768  PHE GLU LYS ALA GLU ASN SER SER LEU ASN LEU ILE GLY          
SEQRES  18 E  768  LYS ALA LYS THR LYS GLU ASN ARG GLN SER ILE ILE ASN          
SEQRES  19 E  768  PRO ASP TRP ASN PHE GLU LYS MET GLY ILE GLY GLY LEU          
SEQRES  20 E  768  ASP LYS GLU PHE SER ASP ILE PHE ARG ARG ALA PHE ALA          
SEQRES  21 E  768  SER ARG VAL PHE PRO PRO GLU ILE VAL GLU GLN MET GLY          
SEQRES  22 E  768  CYS LYS HIS VAL LYS GLY ILE LEU LEU TYR GLY PRO PRO          
SEQRES  23 E  768  GLY CYS GLY LYS THR LEU LEU ALA ARG GLN ILE GLY LYS          
SEQRES  24 E  768  MET LEU ASN ALA ARG GLU PRO LYS VAL VAL ASN GLY PRO          
SEQRES  25 E  768  GLU ILE LEU ASN LYS TYR VAL GLY GLU SER GLU ALA ASN          
SEQRES  26 E  768  ILE ARG LYS LEU PHE ALA ASP ALA GLU GLU GLU GLN ARG          
SEQRES  27 E  768  ARG LEU GLY ALA ASN SER GLY LEU HIS ILE ILE ILE PHE          
SEQRES  28 E  768  ASP GLU ILE ASP ALA ILE CYS LYS GLN ARG GLY SER MET          
SEQRES  29 E  768  ALA GLY SER THR GLY VAL HIS ASP THR VAL VAL ASN GLN          
SEQRES  30 E  768  LEU LEU SER LYS ILE ASP GLY VAL GLU GLN LEU ASN ASN          
SEQRES  31 E  768  ILE LEU VAL ILE GLY MET THR ASN ARG PRO ASP LEU ILE          
SEQRES  32 E  768  ASP GLU ALA LEU LEU ARG PRO GLY ARG LEU GLU VAL LYS          
SEQRES  33 E  768  MET GLU ILE GLY LEU PRO ASP GLU LYS GLY ARG LEU GLN          
SEQRES  34 E  768  ILE LEU HIS ILE HIS THR ALA ARG MET ARG GLY HIS GLN          
SEQRES  35 E  768  LEU LEU SER ALA ASP VAL ASP ILE LYS GLU LEU ALA VAL          
SEQRES  36 E  768  GLU THR LYS ASN PHE SER GLY ALA GLU LEU GLU GLY LEU          
SEQRES  37 E  768  VAL ARG ALA ALA GLN SER THR ALA MET ASN ARG HIS ILE          
SEQRES  38 E  768  ILE ALA SER THR LYS VAL GLU VAL ASP MET GLU LYS ALA          
SEQRES  39 E  768  GLU SER LEU GLN VAL THR ARG GLY ASP PHE LEU ALA SER          
SEQRES  40 E  768  LEU GLU ASN ASP ILE LYS PRO ALA PHE GLY THR ASN GLN          
SEQRES  41 E  768  GLU ASP TYR ALA SER TYR ILE MET ASN GLY ILE ILE LYS          
SEQRES  42 E  768  TRP GLY ASP PRO VAL THR ARG VAL LEU ASP ASP GLY GLU          
SEQRES  43 E  768  LEU LEU VAL GLN GLN THR LYS ASN SER ASP ARG THR PRO          
SEQRES  44 E  768  LEU VAL SER VAL LEU LEU GLU GLY PRO PRO HIS SER GLY          
SEQRES  45 E  768  LYS THR ALA LEU ALA ALA LYS ILE ALA GLU GLU SER ASN          
SEQRES  46 E  768  PHE PRO PHE ILE LYS ILE CYS SER PRO ASP LYS MET ILE          
SEQRES  47 E  768  GLY PHE SER GLU THR ALA LYS CYS GLN ALA MET LYS LYS          
SEQRES  48 E  768  ILE PHE ASP ASP ALA TYR LYS SER GLN LEU SER CYS VAL          
SEQRES  49 E  768  VAL VAL ASP ASP ILE GLU ARG LEU LEU ASP TYR VAL PRO          
SEQRES  50 E  768  ILE GLY PRO ARG PHE SER ASN LEU VAL LEU GLN ALA LEU          
SEQRES  51 E  768  LEU VAL LEU LEU LYS LYS ALA PRO PRO GLN GLY ARG LYS          
SEQRES  52 E  768  LEU LEU ILE ILE GLY THR THR SER ARG LYS ASP VAL LEU          
SEQRES  53 E  768  GLN GLU MET GLU MET LEU ASN ALA PHE SER THR THR ILE          
SEQRES  54 E  768  HIS VAL PRO ASN ILE ALA THR GLY GLU GLN LEU LEU GLU          
SEQRES  55 E  768  ALA LEU GLU LEU LEU GLY ASN PHE LYS ASP LYS GLU ARG          
SEQRES  56 E  768  THR THR ILE ALA GLN GLN VAL LYS GLY LYS LYS VAL TRP          
SEQRES  57 E  768  ILE GLY ILE LYS LYS LEU LEU MET LEU ILE GLU MET SER          
SEQRES  58 E  768  LEU GLN MET ASP PRO GLU TYR ARG VAL ARG LYS PHE LEU          
SEQRES  59 E  768  ALA LEU LEU ARG GLU GLU GLY ALA SER PRO LEU ASP PHE          
SEQRES  60 E  768  ASP                                                          
SEQRES   1 F  768  MET GLY HIS HIS HIS HIS HIS HIS ASP TYR ASP ILE PRO          
SEQRES   2 F  768  THR THR GLU ASN LEU TYR PHE GLN GLY ALA HIS MET ALA          
SEQRES   3 F  768  GLY ARG SER MET GLN ALA ALA ARG CYS PRO THR ASP GLU          
SEQRES   4 F  768  LEU SER LEU SER ASN CYS ALA VAL VAL SER GLU LYS ASP          
SEQRES   5 F  768  TYR GLN SER GLY GLN HIS VAL ILE VAL ARG THR SER PRO          
SEQRES   6 F  768  ASN HIS LYS TYR ILE PHE THR LEU ARG THR HIS PRO SER          
SEQRES   7 F  768  VAL VAL PRO GLY SER VAL ALA PHE SER LEU PRO GLN ARG          
SEQRES   8 F  768  LYS TRP ALA GLY LEU SER ILE GLY GLN GLU ILE GLU VAL          
SEQRES   9 F  768  ALA LEU TYR SER PHE ASP LYS ALA LYS GLN CYS ILE GLY          
SEQRES  10 F  768  THR MET THR ILE GLU ILE ASP PHE LEU GLN LYS LYS ASN          
SEQRES  11 F  768  ILE ASP SER ASN PRO TYR ASP THR ASP LYS MET ALA ALA          
SEQRES  12 F  768  GLU PHE ILE GLN GLN PHE ASN ASN GLN ALA PHE SER VAL          
SEQRES  13 F  768  GLY GLN GLN LEU VAL PHE SER PHE ASN ASP LYS LEU PHE          
SEQRES  14 F  768  GLY LEU LEU VAL LYS ASP ILE GLU ALA MET ASP PRO SER          
SEQRES  15 F  768  ILE LEU LYS GLY GLU PRO ALA SER GLY LYS ARG GLN LYS          
SEQRES  16 F  768  ILE GLU VAL GLY LEU VAL VAL GLY ASN SER GLN VAL ALA          
SEQRES  17 F  768  PHE GLU LYS ALA GLU ASN SER SER LEU ASN LEU ILE GLY          
SEQRES  18 F  768  LYS ALA LYS THR LYS GLU ASN ARG GLN SER ILE ILE ASN          
SEQRES  19 F  768  PRO ASP TRP ASN PHE GLU LYS MET GLY ILE GLY GLY LEU          
SEQRES  20 F  768  ASP LYS GLU PHE SER ASP ILE PHE ARG ARG ALA PHE ALA          
SEQRES  21 F  768  SER ARG VAL PHE PRO PRO GLU ILE VAL GLU GLN MET GLY          
SEQRES  22 F  768  CYS LYS HIS VAL LYS GLY ILE LEU LEU TYR GLY PRO PRO          
SEQRES  23 F  768  GLY CYS GLY LYS THR LEU LEU ALA ARG GLN ILE GLY LYS          
SEQRES  24 F  768  MET LEU ASN ALA ARG GLU PRO LYS VAL VAL ASN GLY PRO          
SEQRES  25 F  768  GLU ILE LEU ASN LYS TYR VAL GLY GLU SER GLU ALA ASN          
SEQRES  26 F  768  ILE ARG LYS LEU PHE ALA ASP ALA GLU GLU GLU GLN ARG          
SEQRES  27 F  768  ARG LEU GLY ALA ASN SER GLY LEU HIS ILE ILE ILE PHE          
SEQRES  28 F  768  ASP GLU ILE ASP ALA ILE CYS LYS GLN ARG GLY SER MET          
SEQRES  29 F  768  ALA GLY SER THR GLY VAL HIS ASP THR VAL VAL ASN GLN          
SEQRES  30 F  768  LEU LEU SER LYS ILE ASP GLY VAL GLU GLN LEU ASN ASN          
SEQRES  31 F  768  ILE LEU VAL ILE GLY MET THR ASN ARG PRO ASP LEU ILE          
SEQRES  32 F  768  ASP GLU ALA LEU LEU ARG PRO GLY ARG LEU GLU VAL LYS          
SEQRES  33 F  768  MET GLU ILE GLY LEU PRO ASP GLU LYS GLY ARG LEU GLN          
SEQRES  34 F  768  ILE LEU HIS ILE HIS THR ALA ARG MET ARG GLY HIS GLN          
SEQRES  35 F  768  LEU LEU SER ALA ASP VAL ASP ILE LYS GLU LEU ALA VAL          
SEQRES  36 F  768  GLU THR LYS ASN PHE SER GLY ALA GLU LEU GLU GLY LEU          
SEQRES  37 F  768  VAL ARG ALA ALA GLN SER THR ALA MET ASN ARG HIS ILE          
SEQRES  38 F  768  ILE ALA SER THR LYS VAL GLU VAL ASP MET GLU LYS ALA          
SEQRES  39 F  768  GLU SER LEU GLN VAL THR ARG GLY ASP PHE LEU ALA SER          
SEQRES  40 F  768  LEU GLU ASN ASP ILE LYS PRO ALA PHE GLY THR ASN GLN          
SEQRES  41 F  768  GLU ASP TYR ALA SER TYR ILE MET ASN GLY ILE ILE LYS          
SEQRES  42 F  768  TRP GLY ASP PRO VAL THR ARG VAL LEU ASP ASP GLY GLU          
SEQRES  43 F  768  LEU LEU VAL GLN GLN THR LYS ASN SER ASP ARG THR PRO          
SEQRES  44 F  768  LEU VAL SER VAL LEU LEU GLU GLY PRO PRO HIS SER GLY          
SEQRES  45 F  768  LYS THR ALA LEU ALA ALA LYS ILE ALA GLU GLU SER ASN          
SEQRES  46 F  768  PHE PRO PHE ILE LYS ILE CYS SER PRO ASP LYS MET ILE          
SEQRES  47 F  768  GLY PHE SER GLU THR ALA LYS CYS GLN ALA MET LYS LYS          
SEQRES  48 F  768  ILE PHE ASP ASP ALA TYR LYS SER GLN LEU SER CYS VAL          
SEQRES  49 F  768  VAL VAL ASP ASP ILE GLU ARG LEU LEU ASP TYR VAL PRO          
SEQRES  50 F  768  ILE GLY PRO ARG PHE SER ASN LEU VAL LEU GLN ALA LEU          
SEQRES  51 F  768  LEU VAL LEU LEU LYS LYS ALA PRO PRO GLN GLY ARG LYS          
SEQRES  52 F  768  LEU LEU ILE ILE GLY THR THR SER ARG LYS ASP VAL LEU          
SEQRES  53 F  768  GLN GLU MET GLU MET LEU ASN ALA PHE SER THR THR ILE          
SEQRES  54 F  768  HIS VAL PRO ASN ILE ALA THR GLY GLU GLN LEU LEU GLU          
SEQRES  55 F  768  ALA LEU GLU LEU LEU GLY ASN PHE LYS ASP LYS GLU ARG          
SEQRES  56 F  768  THR THR ILE ALA GLN GLN VAL LYS GLY LYS LYS VAL TRP          
SEQRES  57 F  768  ILE GLY ILE LYS LYS LEU LEU MET LEU ILE GLU MET SER          
SEQRES  58 F  768  LEU GLN MET ASP PRO GLU TYR ARG VAL ARG LYS PHE LEU          
SEQRES  59 F  768  ALA LEU LEU ARG GLU GLU GLY ALA SER PRO LEU ASP PHE          
SEQRES  60 F  768  ASP                                                          
SEQRES   1 H  207  MET ALA SER MET ALA GLU ASP ALA ASP MET ARG ASN GLU          
SEQRES   2 H  207  LEU GLU GLU MET GLN ARG ARG ALA ASP GLN LEU ALA ASP          
SEQRES   3 H  207  GLU SER LEU GLU SER THR ARG ARG MET LEU GLN LEU VAL          
SEQRES   4 H  207  GLU GLU SER LYS ASP ALA GLY ILE ARG THR LEU VAL MET          
SEQRES   5 H  207  LEU ASP GLU GLN GLY GLU GLN LEU ASP ARG VAL GLU GLU          
SEQRES   6 H  207  GLY MET ASN HIS ILE ASN GLN ASP MET LYS GLU ALA GLU          
SEQRES   7 H  207  LYS ASN LEU LYS ASP LEU GLY LYS CYS CYS GLY LEU PHE          
SEQRES   8 H  207  ILE CYS PRO CYS ASN LYS LEU LYS SER SER ASP ALA TYR          
SEQRES   9 H  207  LYS LYS ALA TRP GLY ASN ASN GLN ASP GLY VAL VAL ALA          
SEQRES  10 H  207  SER GLN PRO ALA ARG VAL VAL ASP GLU ARG GLU GLN MET          
SEQRES  11 H  207  ALA ILE SER GLY GLY PHE ILE ARG ARG VAL THR ASN ASP          
SEQRES  12 H  207  ALA ARG GLU ASN GLU MET ASP GLU ASN LEU GLU GLN VAL          
SEQRES  13 H  207  SER GLY ILE ILE GLY ASN LEU ARG HIS MET ALA LEU ASP          
SEQRES  14 H  207  MET GLY ASN GLU ILE ASP THR GLN ASN ARG GLN ILE ASP          
SEQRES  15 H  207  ARG ILE MET GLU LYS ALA ASP SER ASN LYS THR ARG ILE          
SEQRES  16 H  207  ASP GLU ALA ASN GLN ARG ALA THR LYS MET LEU GLY              
SEQRES   1 I  256  MET LYS ASP ARG THR GLN GLU LEU ARG THR ALA LYS ASP          
SEQRES   2 I  256  SER ASP ASP ASP ASP ASP VAL THR VAL THR VAL ASP ARG          
SEQRES   3 I  256  ASP ARG PHE MET ASP GLU PHE PHE GLU GLN VAL GLU GLU          
SEQRES   4 I  256  ILE ARG GLY PHE ILE ASP LYS ILE ALA GLU ASN VAL GLU          
SEQRES   5 I  256  GLU VAL LYS ARG LYS HIS SER ALA ILE LEU ALA SER PRO          
SEQRES   6 I  256  ASN PRO ASP GLU LYS THR LYS GLU GLU LEU GLU GLU LEU          
SEQRES   7 I  256  MET SER ASP ILE LYS LYS THR ALA ASN LYS VAL ARG SER          
SEQRES   8 I  256  LYS LEU LYS SER ILE GLU GLN SER ILE GLU GLN GLU GLU          
SEQRES   9 I  256  GLY LEU ASN ARG SER SER ALA ASP LEU ARG ILE ARG LYS          
SEQRES  10 I  256  THR GLN HIS SER THR LEU SER ARG LYS PHE VAL GLU VAL          
SEQRES  11 I  256  MET SER GLU TYR ASN ALA THR GLN SER ASP TYR ARG GLU          
SEQRES  12 I  256  ARG SER LYS GLY ARG ILE GLN ARG GLN LEU GLU ILE THR          
SEQRES  13 I  256  GLY ARG THR THR THR SER GLU GLU LEU GLU ASP MET LEU          
SEQRES  14 I  256  GLU SER GLY ASN PRO ALA ILE PHE ALA SER GLY ILE ILE          
SEQRES  15 I  256  MET ASP SER SER ILE SER LYS GLN ALA LEU SER GLU ILE          
SEQRES  16 I  256  GLU THR ARG HIS SER GLU ILE ILE LYS LEU GLU ASN SER          
SEQRES  17 I  256  ILE ARG GLU LEU HIS ASP MET PHE MET ASP MET ALA MET          
SEQRES  18 I  256  LEU VAL GLU SER GLN GLY GLU MET ILE ASP ARG ILE GLU          
SEQRES  19 I  256  TYR ASN VAL GLU HIS ALA VAL ASP TYR VAL GLU ARG ALA          
SEQRES  20 I  256  VAL SER ASP THR LYS LYS ALA VAL LYS                          
SEQRES   1 J  117  MET ALA SER TYR TYR HIS HIS HIS HIS HIS HIS ASP TYR          
SEQRES   2 J  117  ASP ILE PRO THR SER GLU ASN LEU TYR PHE GLN GLY ALA          
SEQRES   3 J  117  SER HIS MET SER ALA THR ALA ALA THR VAL PRO PRO ALA          
SEQRES   4 J  117  ALA PRO ALA GLY GLU GLY GLY PRO PRO ALA PRO PRO PRO          
SEQRES   5 J  117  ASN LEU THR SER ASN ARG ARG LEU GLN GLN THR GLN ALA          
SEQRES   6 J  117  GLN VAL ASP GLU VAL VAL ASP ILE MET ARG VAL ASN VAL          
SEQRES   7 J  117  ASP LYS VAL LEU GLU ARG ASP GLN LYS LEU SER GLU LEU          
SEQRES   8 J  117  ASP ASP ARG ALA ASP ALA LEU GLN ALA GLY ALA SER GLN          
SEQRES   9 J  117  PHE GLU THR SER ALA ALA LYS LEU LYS ARG LYS TYR TRP          
SEQRES   1 K  313  MET HIS HIS HIS HIS HIS HIS HIS HIS HIS HIS GLU ASN          
SEQRES   2 K  313  LEU TYR PHE GLN GLY MET ASP THR SER GLY LYS GLN ALA          
SEQRES   3 K  313  GLU ALA MET ALA LEU LEU ALA GLU ALA GLU ARG LYS VAL          
SEQRES   4 K  313  LYS ASN SER GLN SER PHE PHE SER GLY LEU PHE GLY GLY          
SEQRES   5 K  313  SER SER LYS ILE GLU GLU ALA CYS GLU ILE TYR ALA ARG          
SEQRES   6 K  313  ALA ALA ASN MET PHE LYS MET ALA LYS ASN TRP SER ALA          
SEQRES   7 K  313  ALA GLY ASN ALA PHE CYS GLN ALA ALA GLN LEU HIS LEU          
SEQRES   8 K  313  GLN LEU GLN SER LYS HIS ASP ALA ALA THR CYS PHE VAL          
SEQRES   9 K  313  ASP ALA GLY ASN ALA PHE LYS LYS ALA ASP PRO GLN GLU          
SEQRES  10 K  313  ALA ILE ASN CYS LEU MET ARG ALA ILE GLU ILE TYR THR          
SEQRES  11 K  313  ASP MET GLY ARG PHE THR ILE ALA ALA LYS HIS HIS ILE          
SEQRES  12 K  313  SER ILE ALA GLU ILE TYR GLU THR GLU LEU VAL ASP VAL          
SEQRES  13 K  313  GLU LYS ALA ILE ALA HIS TYR GLU GLN SER ALA ASP TYR          
SEQRES  14 K  313  TYR LYS GLY GLU GLU SER ASN SER SER ALA ASN LYS CYS          
SEQRES  15 K  313  LEU LEU LYS VAL ALA GLY TYR ALA ALA GLN LEU GLU GLN          
SEQRES  16 K  313  TYR GLN LYS ALA ILE ASP ILE TYR GLU GLN VAL GLY THR          
SEQRES  17 K  313  SER ALA MET ASP SER PRO LEU LEU LYS TYR SER ALA LYS          
SEQRES  18 K  313  ASP TYR PHE PHE LYS ALA ALA LEU CYS HIS PHE CYS ILE          
SEQRES  19 K  313  ASP MET LEU ASN ALA LYS LEU ALA VAL GLN LYS TYR GLU          
SEQRES  20 K  313  GLU LEU PHE PRO ALA PHE SER ASP SER ARG GLU CYS LYS          
SEQRES  21 K  313  LEU MET LYS LYS LEU LEU GLU ALA HIS GLU GLU GLN ASN          
SEQRES  22 K  313  VAL ASP SER TYR THR GLU SER VAL LYS GLU TYR ASP SER          
SEQRES  23 K  313  ILE SER ARG LEU ASP GLN TRP LEU THR THR MET LEU LEU          
SEQRES  24 K  313  ARG ILE LYS LYS THR ILE GLN GLY ASP GLU GLU ASP LEU          
SEQRES  25 K  313  ARG                                                          
SEQRES   1 L  313  MET HIS HIS HIS HIS HIS HIS HIS HIS HIS HIS GLU ASN          
SEQRES   2 L  313  LEU TYR PHE GLN GLY MET ASP THR SER GLY LYS GLN ALA          
SEQRES   3 L  313  GLU ALA MET ALA LEU LEU ALA GLU ALA GLU ARG LYS VAL          
SEQRES   4 L  313  LYS ASN SER GLN SER PHE PHE SER GLY LEU PHE GLY GLY          
SEQRES   5 L  313  SER SER LYS ILE GLU GLU ALA CYS GLU ILE TYR ALA ARG          
SEQRES   6 L  313  ALA ALA ASN MET PHE LYS MET ALA LYS ASN TRP SER ALA          
SEQRES   7 L  313  ALA GLY ASN ALA PHE CYS GLN ALA ALA GLN LEU HIS LEU          
SEQRES   8 L  313  GLN LEU GLN SER LYS HIS ASP ALA ALA THR CYS PHE VAL          
SEQRES   9 L  313  ASP ALA GLY ASN ALA PHE LYS LYS ALA ASP PRO GLN GLU          
SEQRES  10 L  313  ALA ILE ASN CYS LEU MET ARG ALA ILE GLU ILE TYR THR          
SEQRES  11 L  313  ASP MET GLY ARG PHE THR ILE ALA ALA LYS HIS HIS ILE          
SEQRES  12 L  313  SER ILE ALA GLU ILE TYR GLU THR GLU LEU VAL ASP VAL          
SEQRES  13 L  313  GLU LYS ALA ILE ALA HIS TYR GLU GLN SER ALA ASP TYR          
SEQRES  14 L  313  TYR LYS GLY GLU GLU SER ASN SER SER ALA ASN LYS CYS          
SEQRES  15 L  313  LEU LEU LYS VAL ALA GLY TYR ALA ALA GLN LEU GLU GLN          
SEQRES  16 L  313  TYR GLN LYS ALA ILE ASP ILE TYR GLU GLN VAL GLY THR          
SEQRES  17 L  313  SER ALA MET ASP SER PRO LEU LEU LYS TYR SER ALA LYS          
SEQRES  18 L  313  ASP TYR PHE PHE LYS ALA ALA LEU CYS HIS PHE CYS ILE          
SEQRES  19 L  313  ASP MET LEU ASN ALA LYS LEU ALA VAL GLN LYS TYR GLU          
SEQRES  20 L  313  GLU LEU PHE PRO ALA PHE SER ASP SER ARG GLU CYS LYS          
SEQRES  21 L  313  LEU MET LYS LYS LEU LEU GLU ALA HIS GLU GLU GLN ASN          
SEQRES  22 L  313  VAL ASP SER TYR THR GLU SER VAL LYS GLU TYR ASP SER          
SEQRES  23 L  313  ILE SER ARG LEU ASP GLN TRP LEU THR THR MET LEU LEU          
SEQRES  24 L  313  ARG ILE LYS LYS THR ILE GLN GLY ASP GLU GLU ASP LEU          
SEQRES  25 L  313  ARG                                                          
HET    ATP  A 801      43                                                       
HET    ADP  A 802      39                                                       
HET    ATP  B 801      43                                                       
HET    ATP  B 802      43                                                       
HET    ATP  C 801      43                                                       
HET    ATP  C 802      43                                                       
HET    ATP  D 801      43                                                       
HET    ATP  D 802      43                                                       
HET    ATP  E 801      43                                                       
HET    ADP  E 802      39                                                       
HET    ATP  F 801      43                                                       
HETNAM     ATP ADENOSINE-5'-TRIPHOSPHATE                                        
HETNAM     ADP ADENOSINE-5'-DIPHOSPHATE                                         
FORMUL  12  ATP    9(C10 H16 N5 O13 P3)                                         
FORMUL  13  ADP    2(C10 H15 N5 O10 P2)                                         
HELIX    1 AA1 THR A   13  LEU A   18  5                                   6    
HELIX    2 AA2 SER A   63  GLY A   71  1                                   9    
HELIX    3 AA3 THR A  114  PHE A  125  1                                  12    
HELIX    4 AA4 LEU A  223  ALA A  234  1                                  12    
HELIX    5 AA5 PRO A  241  GLY A  249  1                                   9    
HELIX    6 AA6 LYS A  266  LEU A  277  1                                  12    
HELIX    7 AA7 GLY A  296  GLY A  317  1                                  22    
HELIX    8 AA8 THR A  349  GLY A  360  1                                  12    
HELIX    9 AA9 ASP A  399  GLN A  418  1                                  20    
HELIX   10 AB1 ASP A  425  GLU A  432  1                                   8    
HELIX   11 AB2 SER A  437  HIS A  456  1                                  20    
HELIX   12 AB3 LEU A  481  ASN A  486  1                                   6    
HELIX   13 AB4 ASP A  498  ILE A  503  1                                   6    
HELIX   14 AB5 GLY A  511  ASN A  530  1                                  20    
HELIX   15 AB6 GLY A  548  SER A  560  1                                  13    
HELIX   16 AB7 SER A  569  ILE A  574  1                                   6    
HELIX   17 AB8 SER A  577  LYS A  594  1                                  18    
HELIX   18 AB9 ASP A  604  LEU A  609  1                                   6    
HELIX   19 AC1 SER A  619  LYS A  632  1                                  14    
HELIX   20 AC2 LYS A  649  MET A  655  1                                   7    
HELIX   21 AC3 THR A  672  GLY A  684  1                                  13    
HELIX   22 AC4 LYS A  687  VAL A  698  1                                  12    
HELIX   23 AC5 GLY A  706  GLN A  719  1                                  14    
HELIX   24 AC6 ASP A  721  ARG A  734  1                                  14    
HELIX   25 AC7 GLU B   15  SER B   19  5                                   5    
HELIX   26 AC8 SER B   63  LYS B   68  1                                   6    
HELIX   27 AC9 ASP B   86  CYS B   91  1                                   6    
HELIX   28 AD1 THR B  114  PHE B  125  1                                  12    
HELIX   29 AD2 LEU B  223  PHE B  240  1                                  18    
HELIX   30 AD3 PRO B  241  GLY B  249  1                                   9    
HELIX   31 AD4 LYS B  266  LEU B  277  1                                  12    
HELIX   32 AD5 GLY B  296  LEU B  316  1                                  21    
HELIX   33 AD6 GLU B  329  CYS B  334  1                                   6    
HELIX   34 AD7 ASP B  348  ASP B  359  1                                  12    
HELIX   35 AD8 ARG B  375  ILE B  379  5                                   5    
HELIX   36 AD9 ASP B  380  ARG B  385  1                                   6    
HELIX   37 AE1 ASP B  399  HIS B  417  1                                  19    
HELIX   38 AE2 ASP B  425  THR B  433  1                                   9    
HELIX   39 AE3 ALA B  439  ARG B  455  1                                  17    
HELIX   40 AE4 LEU B  481  ASN B  486  1                                   6    
HELIX   41 AE5 ASP B  498  TYR B  502  5                                   5    
HELIX   42 AE6 GLY B  511  ASN B  530  1                                  20    
HELIX   43 AE7 GLY B  548  SER B  560  1                                  13    
HELIX   44 AE8 SER B  577  TYR B  593  1                                  17    
HELIX   45 AE9 ASP B  604  LEU B  609  1                                   6    
HELIX   46 AF1 SER B  619  LEU B  630  1                                  12    
HELIX   47 AF2 LYS B  649  MET B  655  1                                   7    
HELIX   48 AF3 GLY B  673  GLY B  684  1                                  12    
HELIX   49 AF4 ASP B  688  VAL B  698  1                                  11    
HELIX   50 AF5 GLY B  706  GLN B  719  1                                  14    
HELIX   51 AF6 ASP B  721  GLU B  735  1                                  15    
HELIX   52 AF7 GLU C   15  SER C   19  5                                   5    
HELIX   53 AF8 SER C   63  GLY C   71  1                                   9    
HELIX   54 AF9 ASP C   86  CYS C   91  1                                   6    
HELIX   55 AG1 GLN C  103  ILE C  107  5                                   5    
HELIX   56 AG2 THR C  114  PHE C  125  1                                  12    
HELIX   57 AG3 GLY C  197  THR C  201  5                                   5    
HELIX   58 AG4 LEU C  223  ALA C  236  1                                  14    
HELIX   59 AG5 PRO C  241  GLY C  249  1                                   9    
HELIX   60 AG6 GLY C  265  MET C  276  1                                  12    
HELIX   61 AG7 GLY C  296  GLY C  317  1                                  22    
HELIX   62 AG8 HIS C  347  ASP C  359  1                                  13    
HELIX   63 AG9 ARG C  375  ILE C  379  5                                   5    
HELIX   64 AH1 ASP C  380  ARG C  385  1                                   6    
HELIX   65 AH2 ASP C  399  HIS C  417  1                                  19    
HELIX   66 AH3 ASP C  425  THR C  433  1                                   9    
HELIX   67 AH4 GLY C  438  ILE C  457  1                                  20    
HELIX   68 AH5 PHE C  480  ASN C  486  1                                   7    
HELIX   69 AH6 GLU C  497  ILE C  503  1                                   7    
HELIX   70 AH7 GLY C  511  SER C  531  1                                  21    
HELIX   71 AH8 LYS C  549  ASN C  561  1                                  13    
HELIX   72 AH9 SER C  577  TYR C  593  1                                  17    
HELIX   73 AI1 ASP C  604  LEU C  609  1                                   6    
HELIX   74 AI2 SER C  619  LYS C  632  1                                  14    
HELIX   75 AI3 LYS C  649  MET C  655  1                                   7    
HELIX   76 AI4 THR C  672  GLY C  684  1                                  13    
HELIX   77 AI5 GLU C  690  LYS C  699  1                                  10    
HELIX   78 AI6 GLY C  706  GLN C  719  1                                  14    
HELIX   79 AI7 ASP C  721  ALA C  738  1                                  18    
HELIX   80 AI8 ASP D   14  SER D   19  5                                   6    
HELIX   81 AI9 SER D   63  GLY D   71  1                                   9    
HELIX   82 AJ1 THR D  114  PHE D  125  1                                  12    
HELIX   83 AJ2 LEU D  223  PHE D  235  1                                  13    
HELIX   84 AJ3 PHE D  235  PHE D  240  1                                   6    
HELIX   85 AJ4 PRO D  242  MET D  248  1                                   7    
HELIX   86 AJ5 GLY D  265  MET D  276  1                                  12    
HELIX   87 AJ6 SER D  298  LEU D  316  1                                  19    
HELIX   88 AJ7 GLU D  329  CYS D  334  1                                   6    
HELIX   89 AJ8 GLY D  345  ASP D  348  5                                   4    
HELIX   90 AJ9 THR D  349  ASP D  359  1                                  11    
HELIX   91 AK1 ASP D  380  LEU D  384  5                                   5    
HELIX   92 AK2 LYS D  401  HIS D  417  1                                  17    
HELIX   93 AK3 ASP D  425  THR D  433  1                                   9    
HELIX   94 AK4 GLY D  438  ILE D  458  1                                  21    
HELIX   95 AK5 LEU D  481  LYS D  489  1                                   9    
HELIX   96 AK6 GLY D  511  SER D  531  1                                  21    
HELIX   97 AK7 GLY D  548  ASN D  561  1                                  14    
HELIX   98 AK8 SER D  577  LYS D  594  1                                  18    
HELIX   99 AK9 ASP D  604  LEU D  609  1                                   6    
HELIX  100 AL1 SER D  619  LYS D  631  1                                  13    
HELIX  101 AL2 VAL D  651  MET D  655  5                                   5    
HELIX  102 AL3 THR D  672  GLY D  684  1                                  13    
HELIX  103 AL4 LYS D  687  LYS D  699  1                                  13    
HELIX  104 AL5 GLY D  706  GLN D  719  1                                  14    
HELIX  105 AL6 ASP D  721  GLY D  737  1                                  17    
HELIX  106 AL7 GLU E  216  ILE E  220  5                                   5    
HELIX  107 AL8 LEU E  223  ALA E  236  1                                  14    
HELIX  108 AL9 GLY E  265  LEU E  277  1                                  13    
HELIX  109 AM1 ASN E  286  LEU E  291  5                                   6    
HELIX  110 AM2 GLY E  296  GLY E  317  1                                  22    
HELIX  111 AM3 GLU E  329  CYS E  334  1                                   6    
HELIX  112 AM4 VAL E  351  GLY E  360  1                                  10    
HELIX  113 AM5 PRO E  376  LEU E  384  1                                   9    
HELIX  114 AM6 ASP E  399  GLY E  416  1                                  18    
HELIX  115 AM7 ASP E  425  THR E  433  1                                   9    
HELIX  116 AM8 GLY E  438  ARG E  455  1                                  18    
HELIX  117 AM9 ASP E  479  LYS E  489  1                                  11    
HELIX  118 AN1 GLY E  511  SER E  531  1                                  21    
HELIX  119 AN2 LYS E  549  ASN E  561  1                                  13    
HELIX  120 AN3 SER E  569  ILE E  574  5                                   6    
HELIX  121 AN4 SER E  577  SER E  595  1                                  19    
HELIX  122 AN5 ASP E  604  LEU E  609  1                                   6    
HELIX  123 AN6 SER E  619  LYS E  632  1                                  14    
HELIX  124 AN7 LYS E  649  MET E  655  1                                   7    
HELIX  125 AN8 THR E  672  GLY E  684  1                                  13    
HELIX  126 AN9 LYS E  687  LYS E  699  1                                  13    
HELIX  127 AO1 GLY E  706  GLN E  719  1                                  14    
HELIX  128 AO2 ARG E  725  ARG E  734  1                                  10    
HELIX  129 AO3 ASP F  224  VAL F  239  1                                  16    
HELIX  130 AO4 GLY F  265  ASN F  278  1                                  14    
HELIX  131 AO5 GLU F  299  LEU F  316  1                                  18    
HELIX  132 AO6 ASP F  348  ASP F  359  1                                  12    
HELIX  133 AO7 ASP F  399  THR F  411  1                                  13    
HELIX  134 AO8 LYS F  427  GLU F  432  1                                   6    
HELIX  135 AO9 THR F  433  PHE F  436  5                                   4    
HELIX  136 AP1 GLY F  443  ASN F  454  1                                  12    
HELIX  137 AP2 TYR F  499  ILE F  503  5                                   5    
HELIX  138 AP3 GLY F  511  ASN F  530  1                                  20    
HELIX  139 AP4 LYS F  549  SER F  560  1                                  12    
HELIX  140 AP5 SER F  577  SER F  595  1                                  19    
HELIX  141 AP6 ASP F  604  LEU F  609  1                                   6    
HELIX  142 AP7 SER F  619  LYS F  632  1                                  14    
HELIX  143 AP8 LYS F  649  MET F  655  1                                   7    
HELIX  144 AP9 THR F  672  GLY F  684  1                                  13    
HELIX  145 AQ1 LYS F  687  GLN F  696  1                                  10    
HELIX  146 AQ2 GLY F  706  MET F  720  1                                  15    
HELIX  147 AQ3 TYR F  724  GLU F  736  1                                  13    
HELIX  148 AQ4 ASP H   19  ALA H   22  5                                   4    
HELIX  149 AQ5 ASP H   23  LEU H   35  1                                  13    
HELIX  150 AQ6 VAL H   36  LYS H   72  1                                  37    
HELIX  151 AQ7 GLU H   73  LYS H   83  1                                  11    
HELIX  152 AQ8 ARG H  142  LYS H  201  1                                  60    
HELIX  153 AQ9 LEU I  192  VAL I  237  1                                  46    
HELIX  154 AR1 GLU I  238  LYS I  252  1                                  15    
HELIX  155 AR2 ARG J   30  ARG J   86  1                                  57    
HELIX  156 AR3 MET K   11  ARG K   19  1                                   9    
HELIX  157 AR4 GLY K   34  ALA K   55  1                                  22    
HELIX  158 AR5 ASN K   57  HIS K   72  1                                  16    
HELIX  159 AR6 LEU K   73  LEU K   75  5                                   3    
HELIX  160 AR7 ASP K   80  ALA K   95  1                                  16    
HELIX  161 AR8 GLU K   99  MET K  114  1                                  16    
HELIX  162 AR9 PHE K  117  GLU K  134  1                                  18    
HELIX  163 AS1 ASP K  137  GLY K  154  1                                  18    
HELIX  164 AS2 SER K  157  GLU K  176  1                                  20    
HELIX  165 AS3 TYR K  178  SER K  195  1                                  18    
HELIX  166 AS4 SER K  201  CYS K  212  1                                  12    
HELIX  167 AS5 LEU K  219  GLN K  226  1                                   8    
HELIX  168 AS6 ALA K  234  SER K  238  5                                   5    
HELIX  169 AS7 CYS K  241  GLU K  253  1                                  13    
HELIX  170 AS8 SER K  258  SER K  270  1                                  13    
HELIX  171 AS9 ASP K  273  GLU K  291  1                                  19    
HELIX  172 AT1 ALA L   10  VAL L   21  1                                  12    
HELIX  173 AT2 GLY L   34  ALA L   55  1                                  22    
HELIX  174 AT3 ALA L   60  GLN L   74  1                                  15    
HELIX  175 AT4 LYS L   78  LYS L   93  1                                  16    
HELIX  176 AT5 GLN L   98  GLY L  115  1                                  18    
HELIX  177 AT6 ARG L  116  GLU L  134  1                                  19    
HELIX  178 AT7 ASP L  137  GLU L  155  1                                  19    
HELIX  179 AT8 SER L  157  GLY L  170  1                                  14    
HELIX  180 AT9 TYR L  171  ALA L  173  5                                   3    
HELIX  181 AU1 GLN L  177  THR L  190  1                                  14    
HELIX  182 AU2 LEU L  198  ALA L  209  1                                  12    
HELIX  183 AU3 LEU L  223  TYR L  228  1                                   6    
HELIX  184 AU4 GLU L  240  GLN L  254  1                                  15    
HELIX  185 AU5 ASN L  255  SER L  270  1                                  16    
HELIX  186 AU6 ASP L  273  GLU L  292  1                                  20    
SHEET    1 AA1 7 ARG A   4  ARG A  10  0                                        
SHEET    2 AA1 7 VAL A  60  PHE A  62  1  O  VAL A  60   N  ALA A   9           
SHEET    3 AA1 7 ALA A  22  VAL A  24 -1  N  VAL A  23   O  ALA A  61           
SHEET    4 AA1 7 LYS A  44  THR A  51  1  O  THR A  48   N  ALA A  22           
SHEET    5 AA1 7 HIS A  34  ARG A  38 -1  N  VAL A  35   O  PHE A  47           
SHEET    6 AA1 7 GLU A  77  LEU A  82 -1  O  ALA A  81   N  ILE A  36           
SHEET    7 AA1 7 ARG A   4  ARG A  10 -1  N  MET A   6   O  ILE A  78           
SHEET    1 AA2 3 ASP A 100  PHE A 101  0                                        
SHEET    2 AA2 3 LYS A 143  ALA A 154 -1  O  GLY A 146   N  ASP A 100           
SHEET    3 AA2 3 SER A 139  PHE A 140 -1  N  PHE A 140   O  LYS A 143           
SHEET    1 AA3 4 GLN A 135  LEU A 136  0                                        
SHEET    2 AA3 4 LYS A 143  ALA A 154 -1  O  LEU A 147   N  LEU A 136           
SHEET    3 AA3 4 ILE A  92  ILE A  97 -1  N  GLY A  93   O  GLU A 153           
SHEET    4 AA3 4 GLN A 182  PHE A 185  1  O  ALA A 184   N  MET A  95           
SHEET    1 AA4 2 PRO A 111  ASP A 113  0                                        
SHEET    2 AA4 2 ASN A 194  ILE A 196  1  O  ILE A 196   N  TYR A 112           
SHEET    1 AA5 2 GLN A 128  SER A 131  0                                        
SHEET    2 AA5 2 VAL A 174  VAL A 177 -1  O  GLY A 175   N  PHE A 130           
SHEET    1 AA6 5 ALA A 279  VAL A 285  0                                        
SHEET    2 AA6 5 LEU A 322  PHE A 327  1  O  ILE A 326   N  VAL A 285           
SHEET    3 AA6 5 ILE A 367  THR A 373  1  O  LEU A 368   N  ILE A 325           
SHEET    4 AA6 5 GLY A 255  TYR A 259  1  N  ILE A 256   O  GLY A 371           
SHEET    5 AA6 5 VAL A 391  GLU A 394  1  O  MET A 393   N  TYR A 259           
SHEET    1 AA7 5 PHE A 564  CYS A 568  0                                        
SHEET    2 AA7 5 LEU A 597  VAL A 602  1  O  VAL A 601   N  LYS A 566           
SHEET    3 AA7 5 LYS A 639  GLY A 644  1  O  ILE A 643   N  VAL A 602           
SHEET    4 AA7 5 LEU A 536  GLU A 542  1  N  LEU A 541   O  GLY A 644           
SHEET    5 AA7 5 THR A 663  HIS A 666  1  O  ILE A 665   N  GLU A 542           
SHEET    1 AA8 7 ARG B   4  ARG B  10  0                                        
SHEET    2 AA8 7 VAL B  60  PHE B  62  1  O  VAL B  60   N  GLN B   7           
SHEET    3 AA8 7 CYS B  21  VAL B  24 -1  N  VAL B  23   O  ALA B  61           
SHEET    4 AA8 7 HIS B  43  THR B  51  1  O  THR B  48   N  ALA B  22           
SHEET    5 AA8 7 HIS B  34  SER B  40 -1  N  VAL B  35   O  PHE B  47           
SHEET    6 AA8 7 GLU B  77  TYR B  83 -1  O  ALA B  81   N  ILE B  36           
SHEET    7 AA8 7 ARG B   4  ARG B  10 -1  N  MET B   6   O  ILE B  78           
SHEET    1 AA9 3 GLN B 135  PHE B 140  0                                        
SHEET    2 AA9 3 LYS B 143  GLU B 153 -1  O  LEU B 147   N  LEU B 136           
SHEET    3 AA9 3 LYS B 171  ILE B 172 -1  O  ILE B 172   N  ILE B 152           
SHEET    1 AB1 4 GLN B 135  PHE B 140  0                                        
SHEET    2 AB1 4 LYS B 143  GLU B 153 -1  O  LEU B 147   N  LEU B 136           
SHEET    3 AB1 4 THR B  94  ASP B 100 -1  N  ASP B 100   O  GLY B 146           
SHEET    4 AB1 4 GLN B 182  LYS B 187  1  O  ALA B 184   N  MET B  95           
SHEET    1 AB2 2 TYR B 112  ASP B 113  0                                        
SHEET    2 AB2 2 LEU B 195  ILE B 196  1  O  ILE B 196   N  TYR B 112           
SHEET    1 AB3 2 GLN B 128  SER B 131  0                                        
SHEET    2 AB3 2 VAL B 174  VAL B 177 -1  O  GLY B 175   N  PHE B 130           
SHEET    1 AB4 5 LYS B 283  VAL B 285  0                                        
SHEET    2 AB4 5 ILE B 325  PHE B 327  1  O  ILE B 326   N  VAL B 285           
SHEET    3 AB4 5 VAL B 369  THR B 373  1  O  ILE B 370   N  ILE B 325           
SHEET    4 AB4 5 GLY B 255  TYR B 259  1  N  LEU B 258   O  GLY B 371           
SHEET    5 AB4 5 LYS B 392  GLU B 394  1  O  MET B 393   N  TYR B 259           
SHEET    1 AB5 5 PHE B 564  CYS B 568  0                                        
SHEET    2 AB5 5 LEU B 597  VAL B 602  1  O  CYS B 599   N  PHE B 564           
SHEET    3 AB5 5 LYS B 639  THR B 646  1  O  LEU B 641   N  SER B 598           
SHEET    4 AB5 5 VAL B 539  GLU B 542  1  N  LEU B 541   O  THR B 646           
SHEET    5 AB5 5 THR B 663  HIS B 666  1  O  ILE B 665   N  GLU B 542           
SHEET    1 AB6 2 ILE B 670  THR B 672  0                                        
SHEET    2 AB6 2 LYS B 702  ILE B 705 -1  O  VAL B 703   N  ALA B 671           
SHEET    1 AB7 7 ARG C   4  ARG C  10  0                                        
SHEET    2 AB7 7 VAL C  60  PHE C  62  1  O  VAL C  60   N  ALA C   9           
SHEET    3 AB7 7 ALA C  22  VAL C  24 -1  N  VAL C  23   O  ALA C  61           
SHEET    4 AB7 7 HIS C  43  THR C  51  1  O  THR C  48   N  ALA C  22           
SHEET    5 AB7 7 HIS C  34  SER C  40 -1  N  VAL C  37   O  TYR C  45           
SHEET    6 AB7 7 GLU C  77  LEU C  82 -1  O  GLU C  79   N  ARG C  38           
SHEET    7 AB7 7 ARG C   4  ARG C  10 -1  N  MET C   6   O  ILE C  78           
SHEET    1 AB8 3 GLN C 135  SER C 139  0                                        
SHEET    2 AB8 3 LEU C 144  ALA C 154 -1  O  LEU C 147   N  LEU C 136           
SHEET    3 AB8 3 GLN C 170  ILE C 172 -1  O  GLN C 170   N  ALA C 154           
SHEET    1 AB9 4 GLN C 135  SER C 139  0                                        
SHEET    2 AB9 4 LEU C 144  ALA C 154 -1  O  LEU C 147   N  LEU C 136           
SHEET    3 AB9 4 THR C  94  ILE C  99 -1  N  GLU C  98   O  LEU C 148           
SHEET    4 AB9 4 GLN C 182  LYS C 187  1  O  ALA C 184   N  MET C  95           
SHEET    1 AC1 2 PRO C 111  ASP C 113  0                                        
SHEET    2 AC1 2 ASN C 194  ILE C 196  1  O  ILE C 196   N  TYR C 112           
SHEET    1 AC2 2 ALA C 129  SER C 131  0                                        
SHEET    2 AC2 2 VAL C 174  LEU C 176 -1  O  GLY C 175   N  PHE C 130           
SHEET    1 AC3 5 LYS C 283  VAL C 284  0                                        
SHEET    2 AC3 5 HIS C 323  ILE C 326  1  O  ILE C 324   N  LYS C 283           
SHEET    3 AC3 5 ILE C 367  THR C 373  1  O  ILE C 370   N  ILE C 325           
SHEET    4 AC3 5 LEU C 257  TYR C 259  1  N  LEU C 258   O  GLY C 371           
SHEET    5 AC3 5 LYS C 392  GLU C 394  1  O  MET C 393   N  TYR C 259           
SHEET    1 AC4 4 LEU C 597  VAL C 601  0                                        
SHEET    2 AC4 4 LYS C 639  THR C 646  1  O  ILE C 643   N  VAL C 600           
SHEET    3 AC4 4 LEU C 536  GLU C 542  1  N  LEU C 541   O  GLY C 644           
SHEET    4 AC4 4 THR C 663  HIS C 666  1  O  ILE C 665   N  GLU C 542           
SHEET    1 AC5 7 ARG D   4  ARG D  10  0                                        
SHEET    2 AC5 7 VAL D  60  PHE D  62  1  O  VAL D  60   N  GLN D   7           
SHEET    3 AC5 7 CYS D  21  VAL D  24 -1  N  VAL D  23   O  ALA D  61           
SHEET    4 AC5 7 LYS D  44  THR D  51  1  O  THR D  48   N  ALA D  22           
SHEET    5 AC5 7 HIS D  34  ARG D  38 -1  N  VAL D  37   O  TYR D  45           
SHEET    6 AC5 7 GLU D  77  LEU D  82 -1  O  ALA D  81   N  ILE D  36           
SHEET    7 AC5 7 ARG D   4  ARG D  10 -1  N  MET D   6   O  ILE D  78           
SHEET    1 AC6 3 GLN D 135  LEU D 136  0                                        
SHEET    2 AC6 3 GLY D 146  ALA D 154 -1  O  LEU D 147   N  LEU D 136           
SHEET    3 AC6 3 GLN D 170  LYS D 171 -1  O  GLN D 170   N  ALA D 154           
SHEET    1 AC7 4 GLN D 135  LEU D 136  0                                        
SHEET    2 AC7 4 GLY D 146  ALA D 154 -1  O  LEU D 147   N  LEU D 136           
SHEET    3 AC7 4 ILE D  92  ASP D 100 -1  N  GLU D  98   O  LEU D 148           
SHEET    4 AC7 4 GLN D 182  LYS D 187  1  O  ALA D 184   N  MET D  95           
SHEET    1 AC8 2 PRO D 111  ASP D 113  0                                        
SHEET    2 AC8 2 ASN D 194  ILE D 196  1  O  ASN D 194   N  TYR D 112           
SHEET    1 AC9 2 ALA D 129  SER D 131  0                                        
SHEET    2 AC9 2 VAL D 174  LEU D 176 -1  O  GLY D 175   N  PHE D 130           
SHEET    1 AD1 2 SER D 139  PHE D 140  0                                        
SHEET    2 AD1 2 LYS D 143  LEU D 144 -1  O  LYS D 143   N  PHE D 140           
SHEET    1 AD2 5 LYS D 283  VAL D 284  0                                        
SHEET    2 AD2 5 HIS D 323  ILE D 326  1  O  ILE D 324   N  LYS D 283           
SHEET    3 AD2 5 ILE D 367  THR D 373  1  O  LEU D 368   N  ILE D 325           
SHEET    4 AD2 5 GLY D 255  TYR D 259  1  N  ILE D 256   O  VAL D 369           
SHEET    5 AD2 5 LYS D 392  GLU D 394  1  O  MET D 393   N  TYR D 259           
SHEET    1 AD3 5 ILE D 565  CYS D 568  0                                        
SHEET    2 AD3 5 LEU D 597  VAL D 602  1  O  VAL D 601   N  CYS D 568           
SHEET    3 AD3 5 LYS D 639  THR D 646  1  O  ILE D 643   N  VAL D 600           
SHEET    4 AD3 5 LEU D 536  GLU D 542  1  N  LEU D 541   O  GLY D 644           
SHEET    5 AD3 5 THR D 663  HIS D 666  1  O  ILE D 665   N  GLU D 542           
SHEET    1 AD4 2 LEU E 258  TYR E 259  0                                        
SHEET    2 AD4 2 MET E 393  GLU E 394  1  O  MET E 393   N  TYR E 259           
SHEET    1 AD5 3 LYS E 283  VAL E 285  0                                        
SHEET    2 AD5 3 ILE E 324  ASP E 328  1  O  ILE E 326   N  LYS E 283           
SHEET    3 AD5 3 LEU E 368  MET E 372  1  O  LEU E 368   N  ILE E 325           
SHEET    1 AD6 4 LEU E 540  GLU E 542  0                                        
SHEET    2 AD6 4 LEU E 641  THR E 646  1  O  GLY E 644   N  LEU E 541           
SHEET    3 AD6 4 SER E 598  VAL E 602  1  N  VAL E 602   O  ILE E 643           
SHEET    4 AD6 4 PHE E 564  CYS E 568  1  N  CYS E 568   O  VAL E 601           
SHEET    1 AD7 4 LEU F 258  TYR F 259  0                                        
SHEET    2 AD7 4 LEU F 368  THR F 373  1  O  THR F 373   N  LEU F 258           
SHEET    3 AD7 4 ILE F 324  ASP F 328  1  N  PHE F 327   O  ILE F 370           
SHEET    4 AD7 4 VAL F 285  ASN F 286  1  N  ASN F 286   O  ASP F 328           
SHEET    1 AD8 5 PHE F 564  CYS F 568  0                                        
SHEET    2 AD8 5 SER F 598  VAL F 602  1  O  VAL F 601   N  CYS F 568           
SHEET    3 AD8 5 LEU F 640  THR F 646  1  O  ILE F 643   N  VAL F 602           
SHEET    4 AD8 5 LEU F 536  GLU F 542  1  N  VAL F 537   O  ILE F 642           
SHEET    5 AD8 5 SER F 662  HIS F 666  1  O  ILE F 665   N  GLU F 542           
SITE     1 AC1 13 ASN A 505  GLY A 506  ILE A 507  ILE A 508                    
SITE     2 AC1 13 TRP A 510  VAL A 514  PRO A 545  HIS A 546                    
SITE     3 AC1 13 GLY A 548  THR A 550  ASP A 604  ILE A 707                    
SITE     4 AC1 13 LYS A 708                                                     
SITE     1 AC2 10 GLY A 221  PRO A 262  CYS A 264  GLY A 265                    
SITE     2 AC2 10 THR A 267  LEU A 268  MET A 372  ILE A 406                    
SITE     3 AC2 10 GLY A 438  GLU A 442                                          
SITE     1 AC3 18 LEU A 355  ASP A 359  ARG A 385  ARG A 388                    
SITE     2 AC3 18 ILE B 220  GLY B 221  PRO B 261  PRO B 262                    
SITE     3 AC3 18 CYS B 264  GLY B 265  LYS B 266  THR B 267                    
SITE     4 AC3 18 LEU B 268  ASN B 374  ILE B 406  HIS B 410                    
SITE     5 AC3 18 GLY B 438  GLU B 442                                          
SITE     1 AC4 12 LYS A 631  ASN B 505  GLY B 506  ILE B 507                    
SITE     2 AC4 12 ILE B 508  PRO B 545  GLY B 548  LYS B 549                    
SITE     3 AC4 12 THR B 550  ALA B 551  ASP B 604  LYS B 708                    
SITE     1 AC5 17 LYS B 631  TYR C 502  MET C 504  ASN C 505                    
SITE     2 AC5 17 GLY C 506  ILE C 507  ILE C 508  TRP C 510                    
SITE     3 AC5 17 PRO C 545  HIS C 546  SER C 547  GLY C 548                    
SITE     4 AC5 17 LYS C 549  THR C 550  LEU C 552  ILE C 707                    
SITE     5 AC5 17 LYS C 708                                                     
SITE     1 AC6 18 ASP B 359  ARG B 385  ARG B 388  GLY C 219                    
SITE     2 AC6 18 ILE C 220  GLY C 221  PRO C 261  PRO C 262                    
SITE     3 AC6 18 GLY C 263  CYS C 264  GLY C 265  LYS C 266                    
SITE     4 AC6 18 THR C 267  LEU C 268  GLU C 329  ILE C 406                    
SITE     5 AC6 18 ALA C 439  GLU C 442                                          
SITE     1 AC7 17 LYS C 631  ASN D 505  GLY D 506  ILE D 507                    
SITE     2 AC7 17 ILE D 508  TRP D 510  VAL D 514  PRO D 545                    
SITE     3 AC7 17 HIS D 546  SER D 547  GLY D 548  LYS D 549                    
SITE     4 AC7 17 THR D 550  LEU D 552  ASP D 604  ILE D 707                    
SITE     5 AC7 17 LYS D 708                                                     
SITE     1 AC8 19 ASP C 359  ARG C 385  ARG C 388  ILE D 220                    
SITE     2 AC8 19 PRO D 262  GLY D 263  CYS D 264  GLY D 265                    
SITE     3 AC8 19 LYS D 266  THR D 267  LEU D 268  ARG D 271                    
SITE     4 AC8 19 GLU D 329  ASN D 374  ILE D 406  HIS D 410                    
SITE     5 AC8 19 GLY D 438  ALA D 439  GLU D 442                               
SITE     1 AC9 15 LYS D 631  ASN E 505  GLY E 506  ILE E 507                    
SITE     2 AC9 15 ILE E 508  TRP E 510  VAL E 514  PRO E 545                    
SITE     3 AC9 15 HIS E 546  GLY E 548  LYS E 549  THR E 550                    
SITE     4 AC9 15 ASP E 604  ILE E 707  LYS E 708                               
SITE     1 AD1 15 ASP D 359  ALA D 382  ARG D 385  ARG D 388                    
SITE     2 AD1 15 ILE E 220  PRO E 262  GLY E 263  CYS E 264                    
SITE     3 AD1 15 GLY E 265  LYS E 266  THR E 267  LEU E 268                    
SITE     4 AD1 15 ASN E 374  ILE E 406  HIS E 410                               
SITE     1 AD2 14 LYS E 631  ASN F 505  ILE F 507  ILE F 508                    
SITE     2 AD2 14 TRP F 510  PRO F 545  HIS F 546  SER F 547                    
SITE     3 AD2 14 GLY F 548  LYS F 549  THR F 550  ASP F 604                    
SITE     4 AD2 14 ILE F 707  LYS F 708                                          
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1           1          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      1.000000  0.000000  0.000000        0.00000                         
SCALE2      0.000000  1.000000  0.000000        0.00000                         
SCALE3      0.000000  0.000000  1.000000        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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