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Database: PDB
Entry: 6MGN
LinkDB: 6MGN
Original site: 6MGN 
HEADER    DNA BINDING PROTEIN                     14-SEP-18   6MGN              
TITLE     MOUSE ID1 (51-104) - HUMAN HE47 (348-399) COMPLEX                     
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: TRANSCRIPTION FACTOR E2-ALPHA;                             
COMPND   3 CHAIN: A;                                                            
COMPND   4 FRAGMENT: UNP RESIDUES 558-609;                                      
COMPND   5 SYNONYM: CLASS B BASIC HELIX-LOOP-HELIX PROTEIN 21,BHLHB21,          
COMPND   6 IMMUNOGLOBULIN ENHANCER-BINDING FACTOR E12/E47,IMMUNOGLOBULIN        
COMPND   7 TRANSCRIPTION FACTOR 1,KAPPA-E2-BINDING FACTOR,TRANSCRIPTION FACTOR  
COMPND   8 3,TCF-3,TRANSCRIPTION FACTOR ITF-1;                                  
COMPND   9 ENGINEERED: YES;                                                     
COMPND  10 MOL_ID: 2;                                                           
COMPND  11 MOLECULE: DNA-BINDING PROTEIN INHIBITOR ID-1;                        
COMPND  12 CHAIN: B;                                                            
COMPND  13 FRAGMENT: UNP RESIDUES 59-104;                                       
COMPND  14 SYNONYM: INHIBITOR OF DNA BINDING 1,INHIBITOR OF DIFFERENTIATION 1;  
COMPND  15 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   3 ORGANISM_COMMON: HUMAN;                                              
SOURCE   4 ORGANISM_TAXID: 9606;                                                
SOURCE   5 GENE: TCF3, BHLHB21, E2A, ITF1;                                      
SOURCE   6 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE   8 MOL_ID: 2;                                                           
SOURCE   9 ORGANISM_SCIENTIFIC: MUS MUSCULUS;                                   
SOURCE  10 ORGANISM_COMMON: MOUSE;                                              
SOURCE  11 ORGANISM_TAXID: 10090;                                               
SOURCE  12 GENE: ID1, ID, ID-1, IDB1;                                           
SOURCE  13 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  14 EXPRESSION_SYSTEM_TAXID: 562                                         
KEYWDS    DNA-BINDING PROTEIN INHIBITOR ID-1, TRANSCRIPTION FACTOR E2-ALPHA     
KEYWDS   2 ISOFORM E47 [HOMO SAPIENS], DNA BINDING PROTEIN                      
EXPDTA    X-RAY DIFFRACTION                                                     
AUTHOR    R.BENEZRA,N.P.PAVLETICH,A.-L.GALL,Y.GOLDGUR                           
REVDAT   2   16-OCT-19 6MGN    1       JRNL                                     
REVDAT   1   18-SEP-19 6MGN    0                                                
JRNL        AUTH   P.M.WOJNAROWICZ,R.LIMA E SILVA,M.OHNAKA,S.B.LEE,Y.CHIN,      
JRNL        AUTH 2 A.KULUKIAN,S.H.CHANG,B.DESAI,M.GARCIA ESCOLANO,R.SHAH,       
JRNL        AUTH 3 M.GARCIA-CAO,S.XU,R.KADAM,Y.GOLDGUR,M.A.MILLER,O.OUERFELLI,  
JRNL        AUTH 4 G.YANG,T.ARAKAWA,S.K.ALBANESE,W.A.GARLAND,G.STOLLER,         
JRNL        AUTH 5 J.CHAUDHARY,L.NORTON,R.K.SONI,J.PHILIP,R.C.HENDRICKSON,      
JRNL        AUTH 6 A.IAVARONE,A.J.DANNENBERG,J.D.CHODERA,N.PAVLETICH,           
JRNL        AUTH 7 A.LASORELLA,P.A.CAMPOCHIARO,R.BENEZRA                        
JRNL        TITL   A SMALL-MOLECULE PAN-ID ANTAGONIST INHIBITS PATHOLOGIC       
JRNL        TITL 2 OCULAR NEOVASCULARIZATION.                                   
JRNL        REF    CELL REP                      V.  29    62 2019              
JRNL        REFN                   ESSN 2211-1247                               
JRNL        PMID   31577956                                                     
JRNL        DOI    10.1016/J.CELREP.2019.08.073                                 
REMARK   2                                                                      
REMARK   2 RESOLUTION.    1.90 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   PROGRAM     : PHENIX 1.10_2155                                     
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VINCENT CHEN,IAN            
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-KUNSTLEVE,           
REMARK   3               : LI-WEI HUNG,ROBERT IMMORMINO,TOM IOERGER,            
REMARK   3               : AIRLIE MCCOY,ERIK MCKEE,NIGEL MORIARTY,              
REMARK   3               : REETAL PAI,RANDY READ,JANE RICHARDSON,               
REMARK   3               : DAVID RICHARDSON,TOD ROMO,JIM SACCHETTINI,           
REMARK   3               : NICHOLAS SAUTER,JACOB SMITH,LAURENT                  
REMARK   3               : STORONI,TOM TERWILLIGER,PETER ZWART                  
REMARK   3                                                                      
REMARK   3    REFINEMENT TARGET : NULL                                          
REMARK   3                                                                      
REMARK   3  DATA USED IN REFINEMENT.                                            
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 1.90                           
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 19.43                          
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : 1.350                          
REMARK   3   COMPLETENESS FOR RANGE        (%) : 98.5                           
REMARK   3   NUMBER OF REFLECTIONS             : 10248                          
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT.                                     
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.186                           
REMARK   3   R VALUE            (WORKING SET) : 0.183                           
REMARK   3   FREE R VALUE                     : 0.218                           
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 10.330                          
REMARK   3   FREE R VALUE TEST SET COUNT      : 1059                            
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).                           
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE        
REMARK   3     1 19.4330 -  3.7928    0.96     1232   138  0.1898 0.2293        
REMARK   3     2  3.7928 -  3.0141    0.98     1165   126  0.1746 0.1848        
REMARK   3     3  3.0141 -  2.6342    0.98     1132   147  0.1872 0.2110        
REMARK   3     4  2.6342 -  2.3938    0.99     1135   141  0.1751 0.2297        
REMARK   3     5  2.3938 -  2.2225    0.99     1128   138  0.1694 0.2032        
REMARK   3     6  2.2225 -  2.0916    0.99     1142   122  0.1722 0.2107        
REMARK   3     7  2.0916 -  1.9870    1.00     1132   130  0.1786 0.2235        
REMARK   3     8  1.9870 -  1.9005    0.99     1123   117  0.2326 0.3229        
REMARK   3                                                                      
REMARK   3  BULK SOLVENT MODELLING.                                             
REMARK   3   METHOD USED        : NULL                                          
REMARK   3   SOLVENT RADIUS     : 1.11                                          
REMARK   3   SHRINKAGE RADIUS   : 0.90                                          
REMARK   3   K_SOL              : NULL                                          
REMARK   3   B_SOL              : NULL                                          
REMARK   3                                                                      
REMARK   3  ERROR ESTIMATES.                                                    
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : 0.200            
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 18.860           
REMARK   3                                                                      
REMARK   3  B VALUES.                                                           
REMARK   3   FROM WILSON PLOT           (A**2) : NULL                           
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : NULL                           
REMARK   3   OVERALL ANISOTROPIC B VALUE.                                       
REMARK   3    B11 (A**2) : NULL                                                 
REMARK   3    B22 (A**2) : NULL                                                 
REMARK   3    B33 (A**2) : NULL                                                 
REMARK   3    B12 (A**2) : NULL                                                 
REMARK   3    B13 (A**2) : NULL                                                 
REMARK   3    B23 (A**2) : NULL                                                 
REMARK   3                                                                      
REMARK   3  TWINNING INFORMATION.                                               
REMARK   3   FRACTION: NULL                                                     
REMARK   3   OPERATOR: NULL                                                     
REMARK   3                                                                      
REMARK   3  DEVIATIONS FROM IDEAL VALUES.                                       
REMARK   3                 RMSD          COUNT                                  
REMARK   3   BOND      :  0.007            823                                  
REMARK   3   ANGLE     :  0.714           1103                                  
REMARK   3   CHIRALITY :  0.048            128                                  
REMARK   3   PLANARITY :  0.004            143                                  
REMARK   3   DIHEDRAL  : 11.200            525                                  
REMARK   3                                                                      
REMARK   3  TLS DETAILS                                                         
REMARK   3   NUMBER OF TLS GROUPS  : NULL                                       
REMARK   3                                                                      
REMARK   3  NCS DETAILS                                                         
REMARK   3   NUMBER OF NCS GROUPS : NULL                                        
REMARK   3                                                                      
REMARK   3  OTHER REFINEMENT REMARKS: NULL                                      
REMARK   4                                                                      
REMARK   4 6MGN COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 17-SEP-18.                  
REMARK 100 THE DEPOSITION ID IS D_1000236913.                                   
REMARK 200                                                                      
REMARK 200 EXPERIMENTAL DETAILS                                                 
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION                  
REMARK 200  DATE OF DATA COLLECTION        : 03-FEB-02                          
REMARK 200  TEMPERATURE           (KELVIN) : 100                                
REMARK 200  PH                             : 6.0                                
REMARK 200  NUMBER OF CRYSTALS USED        : 1                                  
REMARK 200                                                                      
REMARK 200  SYNCHROTRON              (Y/N) : Y                                  
REMARK 200  RADIATION SOURCE               : NSLS                               
REMARK 200  BEAMLINE                       : X9A                                
REMARK 200  X-RAY GENERATOR MODEL          : NULL                               
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M                                  
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.92                               
REMARK 200  MONOCHROMATOR                  : NULL                               
REMARK 200  OPTICS                         : NULL                               
REMARK 200                                                                      
REMARK 200  DETECTOR TYPE                  : CCD                                
REMARK 200  DETECTOR MANUFACTURER          : MAR CCD 165 MM                     
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : HKL-2000                           
REMARK 200  DATA SCALING SOFTWARE          : HKL-2000                           
REMARK 200                                                                      
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 10249                              
REMARK 200  RESOLUTION RANGE HIGH      (A) : 1.900                              
REMARK 200  RESOLUTION RANGE LOW       (A) : 20.000                             
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL                               
REMARK 200                                                                      
REMARK 200 OVERALL.                                                             
REMARK 200  COMPLETENESS FOR RANGE     (%) : 98.7                               
REMARK 200  DATA REDUNDANCY                : 7.000                              
REMARK 200  R MERGE                    (I) : NULL                               
REMARK 200  R SYM                      (I) : 0.06400                            
REMARK 200  <I/SIGMA(I)> FOR THE DATA SET  : 29.3000                            
REMARK 200                                                                      
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.                                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 1.90                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 2.00                     
REMARK 200  COMPLETENESS FOR SHELL     (%) : NULL                               
REMARK 200  DATA REDUNDANCY IN SHELL       : NULL                               
REMARK 200  R MERGE FOR SHELL          (I) : NULL                               
REMARK 200  R SYM FOR SHELL            (I) : 0.31700                            
REMARK 200  <I/SIGMA(I)> FOR SHELL         : NULL                               
REMARK 200                                                                      
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH                              
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT        
REMARK 200 SOFTWARE USED: AMORE                                                 
REMARK 200 STARTING MODEL: 5T9O                                                 
REMARK 200                                                                      
REMARK 200 REMARK: NULL                                                         
REMARK 280                                                                      
REMARK 280 CRYSTAL                                                              
REMARK 280 SOLVENT CONTENT, VS   (%): 53.38                                     
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.64                     
REMARK 280                                                                      
REMARK 280 CRYSTALLIZATION CONDITIONS: 0.1 M POTASSIUM PHOSPHATE (PH 6.0),      
REMARK 280  0.25 M NACL, 22.5% PEG8000., VAPOR DIFFUSION, HANGING DROP,         
REMARK 280  TEMPERATURE 295K                                                    
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY                                            
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 42 21 2                        
REMARK 290                                                                      
REMARK 290      SYMOP   SYMMETRY                                                
REMARK 290     NNNMMM   OPERATOR                                                
REMARK 290       1555   X,Y,Z                                                   
REMARK 290       2555   -X,-Y,Z                                                 
REMARK 290       3555   -Y+1/2,X+1/2,Z+1/2                                      
REMARK 290       4555   Y+1/2,-X+1/2,Z+1/2                                      
REMARK 290       5555   -X+1/2,Y+1/2,-Z+1/2                                     
REMARK 290       6555   X+1/2,-Y+1/2,-Z+1/2                                     
REMARK 290       7555   Y,X,-Z                                                  
REMARK 290       8555   -Y,-X,-Z                                                
REMARK 290                                                                      
REMARK 290     WHERE NNN -> OPERATOR NUMBER                                     
REMARK 290           MMM -> TRANSLATION VECTOR                                  
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS                            
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM             
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY                
REMARK 290 RELATED MOLECULES.                                                   
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   2  0.000000 -1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   2  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   3  0.000000 -1.000000  0.000000       27.48100            
REMARK 290   SMTRY2   3  1.000000  0.000000  0.000000       27.48100            
REMARK 290   SMTRY3   3  0.000000  0.000000  1.000000       40.97000            
REMARK 290   SMTRY1   4  0.000000  1.000000  0.000000       27.48100            
REMARK 290   SMTRY2   4 -1.000000  0.000000  0.000000       27.48100            
REMARK 290   SMTRY3   4  0.000000  0.000000  1.000000       40.97000            
REMARK 290   SMTRY1   5 -1.000000  0.000000  0.000000       27.48100            
REMARK 290   SMTRY2   5  0.000000  1.000000  0.000000       27.48100            
REMARK 290   SMTRY3   5  0.000000  0.000000 -1.000000       40.97000            
REMARK 290   SMTRY1   6  1.000000  0.000000  0.000000       27.48100            
REMARK 290   SMTRY2   6  0.000000 -1.000000  0.000000       27.48100            
REMARK 290   SMTRY3   6  0.000000  0.000000 -1.000000       40.97000            
REMARK 290   SMTRY1   7  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY2   7  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY3   7  0.000000  0.000000 -1.000000        0.00000            
REMARK 290   SMTRY1   8  0.000000 -1.000000  0.000000        0.00000            
REMARK 290   SMTRY2   8 -1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY3   8  0.000000  0.000000 -1.000000        0.00000            
REMARK 290                                                                      
REMARK 290 REMARK: NULL                                                         
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC                           
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC                    
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 2260 ANGSTROM**2                          
REMARK 350 SURFACE AREA OF THE COMPLEX: 6550 ANGSTROM**2                        
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -22.0 KCAL/MOL                        
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B                                  
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 375                                                                      
REMARK 375 SPECIAL POSITION                                                     
REMARK 375 THE FOLLOWING ATOMS ARE FOUND TO BE WITHIN 0.15 ANGSTROMS            
REMARK 375 OF A SYMMETRY RELATED ATOM AND ARE ASSUMED TO BE ON SPECIAL          
REMARK 375 POSITIONS.                                                           
REMARK 375                                                                      
REMARK 375 ATOM RES CSSEQI                                                      
REMARK 375      HOH A 738  LIES ON A SPECIAL POSITION.                          
REMARK 375      HOH A 753  LIES ON A SPECIAL POSITION.                          
REMARK 375      HOH A 758  LIES ON A SPECIAL POSITION.                          
REMARK 375      HOH A 780  LIES ON A SPECIAL POSITION.                          
REMARK 375      HOH B 259  LIES ON A SPECIAL POSITION.                          
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   O    HOH A   739     O    HOH A   754              1.81            
REMARK 500   O    HOH A   749     O    HOH B   281              1.89            
REMARK 500   O    HOH A   727     O    HOH B   282              1.95            
REMARK 500   O    HOH B   206     O    HOH B   279              2.08            
REMARK 500   O    HOH B   245     O    HOH B   283              2.09            
REMARK 500   OE1  GLN B    99     O    HOH B   201              2.11            
REMARK 500   O    HOH B   228     O    HOH B   280              2.11            
REMARK 500   O    HOH B   261     O    HOH B   284              2.15            
REMARK 500   O    HOH B   208     O    HOH B   224              2.18            
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS                                             
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS THAT ARE RELATED BY CRYSTALLOGRAPHIC             
REMARK 500 SYMMETRY ARE IN CLOSE CONTACT.  AN ATOM LOCATED WITHIN 0.15          
REMARK 500 ANGSTROMS OF A SYMMETRY RELATED ATOM IS ASSUMED TO BE ON A           
REMARK 500 SPECIAL POSITION AND IS, THEREFORE, LISTED IN REMARK 375             
REMARK 500 INSTEAD OF REMARK 500.  ATOMS WITH NON-BLANK ALTERNATE               
REMARK 500 LOCATION INDICATORS ARE NOT INCLUDED IN THE CALCULATIONS.            
REMARK 500                                                                      
REMARK 500 DISTANCE CUTOFF:                                                     
REMARK 500 2.2 ANGSTROMS FOR CONTACTS NOT INVOLVING HYDROGEN ATOMS              
REMARK 500 1.6 ANGSTROMS FOR CONTACTS INVOLVING HYDROGEN ATOMS                  
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI  SSYMOP   DISTANCE          
REMARK 500   O    HOH A   703     O    HOH B   261     2655     1.85            
REMARK 500   O    HOH B   272     O    HOH B   272     2655     1.99            
REMARK 500   O    HOH A   741     O    HOH A   743     7555     2.00            
REMARK 500   O    HOH A   742     O    HOH B   262     5555     2.14            
REMARK 500   O    HOH A   708     O    HOH A   767     7555     2.18            
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 525                                                                      
REMARK 525 SOLVENT                                                              
REMARK 525                                                                      
REMARK 525 THE SOLVENT MOLECULES HAVE CHAIN IDENTIFIERS THAT                    
REMARK 525 INDICATE THE POLYMER CHAIN WITH WHICH THEY ARE MOST                  
REMARK 525 CLOSELY ASSOCIATED. THE REMARK LISTS ALL THE SOLVENT                 
REMARK 525 MOLECULES WHICH ARE MORE THAN 5A AWAY FROM THE                       
REMARK 525 NEAREST POLYMER CHAIN (M = MODEL NUMBER;                             
REMARK 525 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE                  
REMARK 525 NUMBER; I=INSERTION CODE):                                           
REMARK 525                                                                      
REMARK 525  M RES CSSEQI                                                        
REMARK 525    HOH A 779        DISTANCE =  6.24 ANGSTROMS                       
REMARK 525    HOH A 780        DISTANCE =  6.90 ANGSTROMS                       
DBREF  6MGN A  558   609  UNP    P15923   TFE2_HUMAN     558    609             
DBREF  6MGN B   59   104  UNP    P20067   ID1_MOUSE       59    104             
SEQADV 6MGN MET B   58  UNP  P20067              INITIATING METHIONINE          
SEQRES   1 A   52  ARG VAL ARG ASP ILE ASN GLU ALA PHE ARG GLU LEU GLY          
SEQRES   2 A   52  ARG MET CYS GLN MET HIS LEU LYS SER ASP LYS ALA GLN          
SEQRES   3 A   52  THR LYS LEU LEU ILE LEU GLN GLN ALA VAL GLN VAL ILE          
SEQRES   4 A   52  LEU GLY LEU GLU GLN GLN VAL ARG GLU ARG ASN LEU ASN          
SEQRES   1 B   47  MET LEU TYR ASP MET ASN GLY CYS TYR SER ARG LEU LYS          
SEQRES   2 B   47  GLU LEU VAL PRO THR LEU PRO GLN ASN ARG LYS VAL SER          
SEQRES   3 B   47  LYS VAL GLU ILE LEU GLN HIS VAL ILE ASP TYR ILE ARG          
SEQRES   4 B   47  ASP LEU GLN LEU GLU LEU ASN SER                              
FORMUL   3  HOH   *167(H2 O)                                                    
HELIX    1 AA1 ASP A  561  LYS A  578  1                                  18    
HELIX    2 AA2 THR A  584  ASN A  607  1                                  24    
HELIX    3 AA3 ASP B   61  VAL B   73  1                                  13    
HELIX    4 AA4 SER B   83  ASN B  103  1                                  21    
CRYST1   54.962   54.962   81.940  90.00  90.00  90.00 P 42 21 2     8          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      0.018194  0.000000  0.000000        0.00000                         
SCALE2      0.000000  0.018194  0.000000        0.00000                         
SCALE3      0.000000  0.000000  0.012204        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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