GenomeNet

Database: PDB
Entry: 6N38
LinkDB: 6N38
Original site: 6N38 
HEADER    PROTEIN TRANSPORT                       14-NOV-18   6N38              
TITLE     STRUCTURE OF THE TYPE VI SECRETION SYSTEM TSSK-TSSF-TSSG BASEPLATE    
TITLE    2 SUBCOMPLEX REVEALED BY CRYO-ELECTRON MICROSCOPY - FULL MAP SHARPENED 
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: PUTATIVE TYPE VI SECRETION PROTEIN;                        
COMPND   3 CHAIN: I, H;                                                         
COMPND   4 SYNONYM: TSSF;                                                       
COMPND   5 ENGINEERED: YES;                                                     
COMPND   6 MOL_ID: 2;                                                           
COMPND   7 MOLECULE: PUTATIVE TYPE VI SECRETION PROTEIN;                        
COMPND   8 CHAIN: G;                                                            
COMPND   9 FRAGMENT: UNP RESIDUES 31-333;                                       
COMPND  10 SYNONYM: TSSG;                                                       
COMPND  11 ENGINEERED: YES;                                                     
COMPND  12 MOL_ID: 3;                                                           
COMPND  13 MOLECULE: UNASSIGNED PROTEIN;                                        
COMPND  14 CHAIN: K, L;                                                         
COMPND  15 ENGINEERED: YES;                                                     
COMPND  16 MOL_ID: 4;                                                           
COMPND  17 MOLECULE: PUTATIVE TYPE VI SECRETION PROTEIN;                        
COMPND  18 CHAIN: A, D, B, E, C, F;                                             
COMPND  19 FRAGMENT: NECK AND SHOULDER DOMAINS (UNP RESIDUES 1-316);            
COMPND  20 SYNONYM: TSSK;                                                       
COMPND  21 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: ESCHERICHIA COLI O44:H18 (STRAIN 042 / EAEC);   
SOURCE   3 ORGANISM_TAXID: 216592;                                              
SOURCE   4 STRAIN: 042 / EAEC;                                                  
SOURCE   5 GENE: EC042_4542;                                                    
SOURCE   6 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE   8 MOL_ID: 2;                                                           
SOURCE   9 ORGANISM_SCIENTIFIC: ESCHERICHIA COLI O44:H18 (STRAIN 042 / EAEC);   
SOURCE  10 ORGANISM_TAXID: 216592;                                              
SOURCE  11 STRAIN: 042 / EAEC;                                                  
SOURCE  12 GENE: EC042_4543;                                                    
SOURCE  13 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  14 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE  15 MOL_ID: 3;                                                           
SOURCE  16 ORGANISM_SCIENTIFIC: ESCHERICHIA COLI O44:H18 (STRAIN 042 / EAEC);   
SOURCE  17 ORGANISM_TAXID: 216592;                                              
SOURCE  18 STRAIN: STRAIN 042 / EAEC;                                           
SOURCE  19 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  20 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE  21 MOL_ID: 4;                                                           
SOURCE  22 ORGANISM_SCIENTIFIC: ESCHERICHIA COLI O44:H18 (STRAIN 042 / EAEC);   
SOURCE  23 ORGANISM_TAXID: 216592;                                              
SOURCE  24 STRAIN: 042 / EAEC;                                                  
SOURCE  25 GENE: EC042_4526;                                                    
SOURCE  26 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  27 EXPRESSION_SYSTEM_TAXID: 562                                         
KEYWDS    TYPE VI SECRETION SYSTEM, ENTEROAGGREGATIVE E. COLI, PROTEIN          
KEYWDS   2 SECRETION, BASEPLATE, STRUCTURAL GENOMICS, SEATTLE STRUCTURAL        
KEYWDS   3 GENOMICS CENTER FOR INFECTIOUS DISEASE, SSGCID, PROTEIN TRANSPORT    
EXPDTA    ELECTRON MICROSCOPY                                                   
AUTHOR    Y.J.PARK,K.D.LACOURSE,C.CAMBILLAU,SEATTLE STRUCTURAL GENOMICS CENTER  
AUTHOR   2 FOR INFECTIOUS DISEASE (SSGCID),F.DIMAIO,J.D.MOUGOUS,D.VEESLER       
REVDAT   3   18-DEC-19 6N38    1       REMARK                                   
REVDAT   2   02-JAN-19 6N38    1       JRNL                                     
REVDAT   1   26-DEC-18 6N38    0                                                
JRNL        AUTH   Y.J.PARK,K.D.LACOURSE,C.CAMBILLAU,F.DIMAIO,J.D.MOUGOUS,      
JRNL        AUTH 2 D.VEESLER                                                    
JRNL        TITL   STRUCTURE OF THE TYPE VI SECRETION SYSTEM TSSK-TSSF-TSSG     
JRNL        TITL 2 BASEPLATE SUBCOMPLEX REVEALED BY CRYO-ELECTRON MICROSCOPY.   
JRNL        REF    NAT COMMUN                    V.   9  5385 2018              
JRNL        REFN                   ESSN 2041-1723                               
JRNL        PMID   30568167                                                     
JRNL        DOI    10.1038/S41467-018-07796-5                                   
REMARK   2                                                                      
REMARK   2 RESOLUTION.    3.70 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   SOFTWARE PACKAGES      : LEGINON, GCTF, RELION                     
REMARK   3   RECONSTRUCTION SCHEMA  : NULL                                      
REMARK   3                                                                      
REMARK   3 EM MAP-MODEL FITTING AND REFINEMENT                                  
REMARK   3   PDB ENTRY                    : NULL                                
REMARK   3   REFINEMENT SPACE             : NULL                                
REMARK   3   REFINEMENT PROTOCOL          : NULL                                
REMARK   3   REFINEMENT TARGET            : NULL                                
REMARK   3   OVERALL ANISOTROPIC B VALUE  : NULL                                
REMARK   3                                                                      
REMARK   3 FITTING PROCEDURE : NULL                                             
REMARK   3                                                                      
REMARK   3 EM IMAGE RECONSTRUCTION STATISTICS                                   
REMARK   3   NOMINAL PIXEL SIZE (ANGSTROMS)    : NULL                           
REMARK   3   ACTUAL PIXEL SIZE  (ANGSTROMS)    : NULL                           
REMARK   3   EFFECTIVE RESOLUTION (ANGSTROMS)  : 3.700                          
REMARK   3   NUMBER OF PARTICLES               : 36496                          
REMARK   3   CTF CORRECTION METHOD             : PHASE FLIPPING AND AMPLITUDE   
REMARK   3                                       CORRECTION                     
REMARK   3                                                                      
REMARK   3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL                    
REMARK   3                                                                      
REMARK   3 OTHER DETAILS: NULL                                                  
REMARK   4                                                                      
REMARK   4 6N38 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 15-NOV-18.                  
REMARK 100 THE DEPOSITION ID IS D_1000238029.                                   
REMARK 245                                                                      
REMARK 245 EXPERIMENTAL DETAILS                                                 
REMARK 245   RECONSTRUCTION METHOD          : SINGLE PARTICLE                   
REMARK 245   SPECIMEN TYPE                  : NULL                              
REMARK 245                                                                      
REMARK 245 ELECTRON MICROSCOPE SAMPLE                                           
REMARK 245   SAMPLE TYPE                    : PARTICLE                          
REMARK 245   PARTICLE TYPE                  : POINT                             
REMARK 245   NAME OF SAMPLE                 : TSSK-TSSF-TSSG T6SS BASEPLATE     
REMARK 245                                    SUBCOMPLEX                        
REMARK 245   SAMPLE CONCENTRATION (MG ML-1) : 0.12                              
REMARK 245   SAMPLE SUPPORT DETAILS         : NULL                              
REMARK 245   SAMPLE VITRIFICATION DETAILS   : NULL                              
REMARK 245   SAMPLE BUFFER                  : NULL                              
REMARK 245   PH                             : 7.80                              
REMARK 245   SAMPLE DETAILS                 : NULL                              
REMARK 245                                                                      
REMARK 245 DATA ACQUISITION                                                     
REMARK 245   DATE OF EXPERIMENT                : NULL                           
REMARK 245   NUMBER OF MICROGRAPHS-IMAGES      : NULL                           
REMARK 245   TEMPERATURE (KELVIN)              : NULL                           
REMARK 245   MICROSCOPE MODEL                  : FEI TITAN KRIOS                
REMARK 245   DETECTOR TYPE                     : GATAN K2 SUMMIT (4K X 4K)      
REMARK 245   MINIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MAXIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MINIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   MAXIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   NOMINAL CS                        : NULL                           
REMARK 245   IMAGING MODE                      : BRIGHT FIELD                   
REMARK 245   ELECTRON DOSE (ELECTRONS NM**-2)  : 40.00                          
REMARK 245   ILLUMINATION MODE                 : FLOOD BEAM                     
REMARK 245   NOMINAL MAGNIFICATION             : NULL                           
REMARK 245   CALIBRATED MAGNIFICATION          : NULL                           
REMARK 245   SOURCE                            : FIELD EMISSION GUN             
REMARK 245   ACCELERATION VOLTAGE (KV)         : 300                            
REMARK 245   IMAGING DETAILS                   : NULL                           
REMARK 247                                                                      
REMARK 247 ELECTRON MICROSCOPY                                                  
REMARK 247  THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON          
REMARK 247  MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE              
REMARK 247  THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES           
REMARK 247  ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION         
REMARK 247  OF THE STRUCTURE FACTORS.                                           
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: UNDECAMERIC                       
REMARK 350 APPLY THE FOLLOWING TO CHAINS: I, G, H, K, L, A, D, B, E, C,         
REMARK 350                    AND CHAINS: F                                     
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     MET I     1                                                      
REMARK 465     ASP I     2                                                      
REMARK 465     ASP I     3                                                      
REMARK 465     LEU I     4                                                      
REMARK 465     THR I     5                                                      
REMARK 465     LEU I     6                                                      
REMARK 465     ARG I     7                                                      
REMARK 465     TYR I     8                                                      
REMARK 465     PHE I     9                                                      
REMARK 465     ASP I    10                                                      
REMARK 465     ALA I    11                                                      
REMARK 465     GLU I    12                                                      
REMARK 465     MET I    13                                                      
REMARK 465     ARG I    14                                                      
REMARK 465     TYR I    15                                                      
REMARK 465     LEU I    16                                                      
REMARK 465     ARG I    17                                                      
REMARK 465     GLU I    18                                                      
REMARK 465     ALA I    19                                                      
REMARK 465     GLY I    20                                                      
REMARK 465     LYS I    21                                                      
REMARK 465     ALA I    22                                                      
REMARK 465     PHE I    23                                                      
REMARK 465     ALA I    24                                                      
REMARK 465     GLN I    25                                                      
REMARK 465     ALA I    26                                                      
REMARK 465     HIS I    27                                                      
REMARK 465     PRO I    28                                                      
REMARK 465     ASP I    29                                                      
REMARK 465     ARG I    30                                                      
REMARK 465     ALA I    31                                                      
REMARK 465     ALA I    32                                                      
REMARK 465     MET I    33                                                      
REMARK 465     LEU I    34                                                      
REMARK 465     ASP I    35                                                      
REMARK 465     LEU I    36                                                      
REMARK 465     ASP I    37                                                      
REMARK 465     LYS I    38                                                      
REMARK 465     ALA I    39                                                      
REMARK 465     GLY I    40                                                      
REMARK 465     THR I    41                                                      
REMARK 465     PRO I    42                                                      
REMARK 465     ASP I    43                                                      
REMARK 465     PRO I    44                                                      
REMARK 465     CYS I    45                                                      
REMARK 465     VAL I    46                                                      
REMARK 465     GLY I   393                                                      
REMARK 465     GLY I   394                                                      
REMARK 465     GLN I   395                                                      
REMARK 465     ARG I   396                                                      
REMARK 465     TRP I   397                                                      
REMARK 465     GLU I   398                                                      
REMARK 465     ALA I   399                                                      
REMARK 465     ASP I   400                                                      
REMARK 465     ARG I   401                                                      
REMARK 465     MET I   402                                                      
REMARK 465     PRO I   403                                                      
REMARK 465     GLU I   404                                                      
REMARK 465     ARG I   405                                                      
REMARK 465     MET G    64                                                      
REMARK 465     GLY G    65                                                      
REMARK 465     PHE G    66                                                      
REMARK 465     PRO G    67                                                      
REMARK 465     ALA G    68                                                      
REMARK 465     SER G    69                                                      
REMARK 465     GLU G    70                                                      
REMARK 465     ILE G    71                                                      
REMARK 465     LYS G    72                                                      
REMARK 465     ASP G    73                                                      
REMARK 465     ALA G    74                                                      
REMARK 465     VAL G    75                                                      
REMARK 465     ILE G    76                                                      
REMARK 465     PRO G    77                                                      
REMARK 465     GLU G    78                                                      
REMARK 465     GLU G    79                                                      
REMARK 465     SER G    80                                                      
REMARK 465     HIS G    81                                                      
REMARK 465     LEU G    82                                                      
REMARK 465     PRO G    83                                                      
REMARK 465     PRO G    84                                                      
REMARK 465     ILE G    85                                                      
REMARK 465     VAL G    86                                                      
REMARK 465     HIS G    87                                                      
REMARK 465     VAL G    88                                                      
REMARK 465     THR G    89                                                      
REMARK 465     PHE G    90                                                      
REMARK 465     MET G    91                                                      
REMARK 465     GLY G    92                                                      
REMARK 465     LEU G    93                                                      
REMARK 465     TYR G    94                                                      
REMARK 465     GLY G    95                                                      
REMARK 465     VAL G    96                                                      
REMARK 465     THR G    97                                                      
REMARK 465     SER G    98                                                      
REMARK 465     PRO G    99                                                      
REMARK 465     LEU G   100                                                      
REMARK 465     PRO G   101                                                      
REMARK 465     ALA G   102                                                      
REMARK 465     HIS G   103                                                      
REMARK 465     TYR G   104                                                      
REMARK 465     ILE G   105                                                      
REMARK 465     SER G   106                                                      
REMARK 465     ASP G   107                                                      
REMARK 465     ILE G   108                                                      
REMARK 465     ALA G   109                                                      
REMARK 465     GLN G   110                                                      
REMARK 465     GLN G   111                                                      
REMARK 465     ARG G   112                                                      
REMARK 465     GLU G   113                                                      
REMARK 465     GLY G   114                                                      
REMARK 465     HIS G   115                                                      
REMARK 465     GLU G   116                                                      
REMARK 465     ALA G   117                                                      
REMARK 465     ALA G   118                                                      
REMARK 465     ALA G   119                                                      
REMARK 465     ASP G   120                                                      
REMARK 465     PHE G   121                                                      
REMARK 465     ILE G   331                                                      
REMARK 465     ALA G   332                                                      
REMARK 465     THR G   333                                                      
REMARK 465     SER G   334                                                      
REMARK 465     ALA G   335                                                      
REMARK 465     MET H     1                                                      
REMARK 465     ASP H     2                                                      
REMARK 465     ASP H     3                                                      
REMARK 465     LEU H     4                                                      
REMARK 465     THR H     5                                                      
REMARK 465     LEU H     6                                                      
REMARK 465     ARG H     7                                                      
REMARK 465     TYR H     8                                                      
REMARK 465     PHE H     9                                                      
REMARK 465     ASP H    10                                                      
REMARK 465     ALA H    11                                                      
REMARK 465     GLU H    12                                                      
REMARK 465     MET H    13                                                      
REMARK 465     ARG H    14                                                      
REMARK 465     TYR H    15                                                      
REMARK 465     LEU H    16                                                      
REMARK 465     ARG H    17                                                      
REMARK 465     GLU H    18                                                      
REMARK 465     ALA H    19                                                      
REMARK 465     GLY H    20                                                      
REMARK 465     LYS H    21                                                      
REMARK 465     ALA H    22                                                      
REMARK 465     PHE H    23                                                      
REMARK 465     ALA H    24                                                      
REMARK 465     GLN H    25                                                      
REMARK 465     ALA H    26                                                      
REMARK 465     HIS H    27                                                      
REMARK 465     PRO H    28                                                      
REMARK 465     ASP H    29                                                      
REMARK 465     ARG H    30                                                      
REMARK 465     ALA H    31                                                      
REMARK 465     ALA H    32                                                      
REMARK 465     MET H    33                                                      
REMARK 465     LEU H    34                                                      
REMARK 465     ASP H    35                                                      
REMARK 465     LEU H    36                                                      
REMARK 465     ASP H    37                                                      
REMARK 465     LYS H    38                                                      
REMARK 465     ALA H    39                                                      
REMARK 465     GLY H    40                                                      
REMARK 465     THR H    41                                                      
REMARK 465     PRO H    42                                                      
REMARK 465     ASP H    43                                                      
REMARK 465     PRO H    44                                                      
REMARK 465     GLY H   393                                                      
REMARK 465     GLY H   394                                                      
REMARK 465     GLN H   395                                                      
REMARK 465     ARG H   396                                                      
REMARK 465     TRP H   397                                                      
REMARK 465     GLU H   398                                                      
REMARK 465     ALA H   399                                                      
REMARK 465     ASP H   400                                                      
REMARK 465     ARG H   401                                                      
REMARK 465     MET H   402                                                      
REMARK 465     PRO H   403                                                      
REMARK 465     UNK L    19                                                      
REMARK 465     UNK L    20                                                      
REMARK 465     UNK L    21                                                      
REMARK 465     MET A     1                                                      
REMARK 465     ARG A   220                                                      
REMARK 465     GLU A   221                                                      
REMARK 465     ASN A   222                                                      
REMARK 465     ASN A   223                                                      
REMARK 465     ALA A   224                                                      
REMARK 465     ARG A   225                                                      
REMARK 465     LEU A   226                                                      
REMARK 465     ALA A   227                                                      
REMARK 465     ASP A   228                                                      
REMARK 465     PHE A   229                                                      
REMARK 465     ALA A   230                                                      
REMARK 465     VAL A   231                                                      
REMARK 465     SER A   313                                                      
REMARK 465     LEU A   314                                                      
REMARK 465     PRO A   315                                                      
REMARK 465     SER A   316                                                      
REMARK 465     HIS A   317                                                      
REMARK 465     HIS A   318                                                      
REMARK 465     HIS A   319                                                      
REMARK 465     HIS A   320                                                      
REMARK 465     HIS A   321                                                      
REMARK 465     HIS A   322                                                      
REMARK 465     MET D     1                                                      
REMARK 465     ARG D   220                                                      
REMARK 465     GLU D   221                                                      
REMARK 465     ASN D   222                                                      
REMARK 465     ASN D   223                                                      
REMARK 465     ALA D   224                                                      
REMARK 465     ARG D   225                                                      
REMARK 465     LEU D   226                                                      
REMARK 465     ALA D   227                                                      
REMARK 465     ASP D   228                                                      
REMARK 465     PHE D   229                                                      
REMARK 465     ALA D   230                                                      
REMARK 465     VAL D   231                                                      
REMARK 465     SER D   313                                                      
REMARK 465     LEU D   314                                                      
REMARK 465     PRO D   315                                                      
REMARK 465     SER D   316                                                      
REMARK 465     HIS D   317                                                      
REMARK 465     HIS D   318                                                      
REMARK 465     HIS D   319                                                      
REMARK 465     HIS D   320                                                      
REMARK 465     HIS D   321                                                      
REMARK 465     HIS D   322                                                      
REMARK 465     ARG B   220                                                      
REMARK 465     GLU B   221                                                      
REMARK 465     ASN B   222                                                      
REMARK 465     ASN B   223                                                      
REMARK 465     ALA B   224                                                      
REMARK 465     ARG B   225                                                      
REMARK 465     LEU B   226                                                      
REMARK 465     ALA B   227                                                      
REMARK 465     ASP B   228                                                      
REMARK 465     PHE B   229                                                      
REMARK 465     ALA B   230                                                      
REMARK 465     VAL B   231                                                      
REMARK 465     ALA B   232                                                      
REMARK 465     LEU B   314                                                      
REMARK 465     PRO B   315                                                      
REMARK 465     SER B   316                                                      
REMARK 465     HIS B   317                                                      
REMARK 465     HIS B   318                                                      
REMARK 465     HIS B   319                                                      
REMARK 465     HIS B   320                                                      
REMARK 465     HIS B   321                                                      
REMARK 465     HIS B   322                                                      
REMARK 465     ARG E   220                                                      
REMARK 465     GLU E   221                                                      
REMARK 465     ASN E   222                                                      
REMARK 465     ASN E   223                                                      
REMARK 465     ALA E   224                                                      
REMARK 465     ARG E   225                                                      
REMARK 465     LEU E   226                                                      
REMARK 465     ALA E   227                                                      
REMARK 465     ASP E   228                                                      
REMARK 465     PHE E   229                                                      
REMARK 465     ALA E   230                                                      
REMARK 465     VAL E   231                                                      
REMARK 465     LEU E   314                                                      
REMARK 465     PRO E   315                                                      
REMARK 465     SER E   316                                                      
REMARK 465     HIS E   317                                                      
REMARK 465     HIS E   318                                                      
REMARK 465     HIS E   319                                                      
REMARK 465     HIS E   320                                                      
REMARK 465     HIS E   321                                                      
REMARK 465     HIS E   322                                                      
REMARK 465     MET C     1                                                      
REMARK 465     ARG C   220                                                      
REMARK 465     GLU C   221                                                      
REMARK 465     ASN C   222                                                      
REMARK 465     ASN C   223                                                      
REMARK 465     ALA C   224                                                      
REMARK 465     ARG C   225                                                      
REMARK 465     LEU C   226                                                      
REMARK 465     ALA C   227                                                      
REMARK 465     ASP C   228                                                      
REMARK 465     PHE C   229                                                      
REMARK 465     ALA C   230                                                      
REMARK 465     VAL C   231                                                      
REMARK 465     SER C   313                                                      
REMARK 465     LEU C   314                                                      
REMARK 465     PRO C   315                                                      
REMARK 465     SER C   316                                                      
REMARK 465     HIS C   317                                                      
REMARK 465     HIS C   318                                                      
REMARK 465     HIS C   319                                                      
REMARK 465     HIS C   320                                                      
REMARK 465     HIS C   321                                                      
REMARK 465     HIS C   322                                                      
REMARK 465     MET F     1                                                      
REMARK 465     ARG F   220                                                      
REMARK 465     GLU F   221                                                      
REMARK 465     ASN F   222                                                      
REMARK 465     ASN F   223                                                      
REMARK 465     ALA F   224                                                      
REMARK 465     ARG F   225                                                      
REMARK 465     LEU F   226                                                      
REMARK 465     ALA F   227                                                      
REMARK 465     ASP F   228                                                      
REMARK 465     PHE F   229                                                      
REMARK 465     ALA F   230                                                      
REMARK 465     VAL F   231                                                      
REMARK 465     LEU F   314                                                      
REMARK 465     PRO F   315                                                      
REMARK 465     SER F   316                                                      
REMARK 465     HIS F   317                                                      
REMARK 465     HIS F   318                                                      
REMARK 465     HIS F   319                                                      
REMARK 465     HIS F   320                                                      
REMARK 465     HIS F   321                                                      
REMARK 465     HIS F   322                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     GLU I  47    CG   CD   OE1  OE2                                  
REMARK 470     ARG I  48    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LEU I  49    CG   CD1  CD2                                       
REMARK 470     PHE I  50    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     GLU I  51    CG   CD   OE1  OE2                                  
REMARK 470     GLU I  70    CG   CD   OE1  OE2                                  
REMARK 470     LYS I 103    CG   CD   CE   NZ                                   
REMARK 470     GLU I 106    CG   CD   OE1  OE2                                  
REMARK 470     GLU I 164    CG   CD   OE1  OE2                                  
REMARK 470     GLU I 210    CG   CD   OE1  OE2                                  
REMARK 470     GLU I 225    CG   CD   OE1  OE2                                  
REMARK 470     GLU I 226    CG   CD   OE1  OE2                                  
REMARK 470     ASP I 234    CG   OD1  OD2                                       
REMARK 470     GLU I 251    CG   CD   OE1  OE2                                  
REMARK 470     ASP I 274    CG   OD1  OD2                                       
REMARK 470     ASP I 292    CG   OD1  OD2                                       
REMARK 470     LEU I 312    CG   CD1  CD2                                       
REMARK 470     ILE I 313    CG1  CG2  CD1                                       
REMARK 470     ILE I 314    CG1  CG2  CD1                                       
REMARK 470     ASN I 315    CG   OD1  ND2                                       
REMARK 470     LEU I 317    CG   CD1  CD2                                       
REMARK 470     GLU I 320    CG   CD   OE1  OE2                                  
REMARK 470     GLN I 329    CG   CD   OE1  NE2                                  
REMARK 470     GLU I 334    CG   CD   OE1  OE2                                  
REMARK 470     ARG I 346    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     THR I 347    OG1  CG2                                            
REMARK 470     ARG I 366    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU I 371    CG   CD   OE1  OE2                                  
REMARK 470     LYS I 379    CG   CD   CE   NZ                                   
REMARK 470     ARG I 380    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     MET I 385    CG   SD   CE                                        
REMARK 470     LEU I 392    CG   CD1  CD2                                       
REMARK 470     GLU I 406    CG   CD   OE1  OE2                                  
REMARK 470     THR I 407    OG1  CG2                                            
REMARK 470     LEU I 408    CG   CD1  CD2                                       
REMARK 470     LEU I 424    CG   CD1  CD2                                       
REMARK 470     ARG I 431    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS I 447    CG   CD   CE   NZ                                   
REMARK 470     GLU I 480    CG   CD   OE1  OE2                                  
REMARK 470     GLU I 495    CG   CD   OE1  OE2                                  
REMARK 470     GLU I 516    CG   CD   OE1  OE2                                  
REMARK 470     ASP I 531    CG   OD1  OD2                                       
REMARK 470     CYS H  45    SG                                                  
REMARK 470     VAL H  46    CG1  CG2                                            
REMARK 470     GLU H  47    CG   CD   OE1  OE2                                  
REMARK 470     ARG H  48    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LEU H  49    CG   CD1  CD2                                       
REMARK 470     PHE H  50    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     GLU H  51    CG   CD   OE1  OE2                                  
REMARK 470     LYS H 103    CG   CD   CE   NZ                                   
REMARK 470     GLU H 106    CG   CD   OE1  OE2                                  
REMARK 470     GLU H 164    CG   CD   OE1  OE2                                  
REMARK 470     ARG H 204    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU H 210    CG   CD   OE1  OE2                                  
REMARK 470     GLU H 225    CG   CD   OE1  OE2                                  
REMARK 470     GLU H 226    CG   CD   OE1  OE2                                  
REMARK 470     ASP H 234    CG   OD1  OD2                                       
REMARK 470     GLU H 251    CG   CD   OE1  OE2                                  
REMARK 470     GLU H 262    CG   CD   OE1  OE2                                  
REMARK 470     ASP H 274    CG   OD1  OD2                                       
REMARK 470     GLU H 276    CG   CD   OE1  OE2                                  
REMARK 470     ASP H 286    CG   OD1  OD2                                       
REMARK 470     ASP H 292    CG   OD1  OD2                                       
REMARK 470     ASP H 310    CG   OD1  OD2                                       
REMARK 470     GLU H 320    CG   CD   OE1  OE2                                  
REMARK 470     ARG H 327    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU H 334    CG   CD   OE1  OE2                                  
REMARK 470     ARG H 346    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     THR H 347    OG1  CG2                                            
REMARK 470     SER H 349    OG                                                  
REMARK 470     GLU H 351    CG   CD   OE1  OE2                                  
REMARK 470     ASP H 368    CG   OD1  OD2                                       
REMARK 470     GLU H 371    CG   CD   OE1  OE2                                  
REMARK 470     MET H 385    CG   SD   CE                                        
REMARK 470     LEU H 392    CG   CD1  CD2                                       
REMARK 470     GLU H 404    CG   CD   OE1  OE2                                  
REMARK 470     ARG H 405    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU H 406    CG   CD   OE1  OE2                                  
REMARK 470     ARG H 431    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU H 457    CG   CD   OE1  OE2                                  
REMARK 470     ASP H 458    CG   OD1  OD2                                       
REMARK 470     ASP H 493    CG   OD1  OD2                                       
REMARK 470     GLU H 495    CG   CD   OE1  OE2                                  
REMARK 470     GLU A 139    CG   CD   OE1  OE2                                  
REMARK 470     GLU A 281    CG   CD   OE1  OE2                                  
REMARK 470     GLU D 120    CG   CD   OE1  OE2                                  
REMARK 470     ASP D 233    CG   OD1  OD2                                       
REMARK 470     ASP B  10    CG   OD1  OD2                                       
REMARK 470     GLU B 120    CG   CD   OE1  OE2                                  
REMARK 470     ASP B 233    CG   OD1  OD2                                       
REMARK 470     GLU B 293    CG   CD   OE1  OE2                                  
REMARK 470     GLU E 118    CG   CD   OE1  OE2                                  
REMARK 470     GLU E 120    CG   CD   OE1  OE2                                  
REMARK 470     GLU E 139    CG   CD   OE1  OE2                                  
REMARK 470     ASP E 233    CG   OD1  OD2                                       
REMARK 470     GLU E 281    CG   CD   OE1  OE2                                  
REMARK 470     GLU E 311    CG   CD   OE1  OE2                                  
REMARK 470     GLU C 118    CG   CD   OE1  OE2                                  
REMARK 470     GLU C 120    CG   CD   OE1  OE2                                  
REMARK 470     GLU C 139    CG   CD   OE1  OE2                                  
REMARK 470     GLN C 175    CG   CD   OE1  NE2                                  
REMARK 470     GLN C 177    CG   CD   OE1  NE2                                  
REMARK 470     ASP C 233    CG   OD1  OD2                                       
REMARK 470     GLU C 311    CG   CD   OE1  OE2                                  
REMARK 470     ASP F  10    CG   OD1  OD2                                       
REMARK 470     GLU F 118    CG   CD   OE1  OE2                                  
REMARK 470     GLU F 120    CG   CD   OE1  OE2                                  
REMARK 470     GLU F 139    CG   CD   OE1  OE2                                  
REMARK 470     GLU F 200    CG   CD   OE1  OE2                                  
REMARK 470     ASP F 233    CG   OD1  OD2                                       
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500    VAL I 101   CA  -  CB  -  CG2 ANGL. DEV. =  16.6 DEGREES          
REMARK 500    LEU I 165   CD1 -  CG  -  CD2 ANGL. DEV. =  22.0 DEGREES          
REMARK 500    VAL I 186   CG1 -  CB  -  CG2 ANGL. DEV. =  20.1 DEGREES          
REMARK 500    LEU I 192   CD1 -  CG  -  CD2 ANGL. DEV. =  21.1 DEGREES          
REMARK 500    LEU I 287   CD1 -  CG  -  CD2 ANGL. DEV. =  21.3 DEGREES          
REMARK 500    LEU I 328   CD1 -  CG  -  CD2 ANGL. DEV. =  20.4 DEGREES          
REMARK 500    LEU I 365   CD1 -  CG  -  CD2 ANGL. DEV. =  22.5 DEGREES          
REMARK 500    LEU H 287   CD1 -  CG  -  CD2 ANGL. DEV. =  21.2 DEGREES          
REMARK 500    VAL D 234   CA  -  CB  -  CG2 ANGL. DEV. =  15.8 DEGREES          
REMARK 500    LEU B 239   CD1 -  CG  -  CD2 ANGL. DEV. =  21.1 DEGREES          
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    ASP I  67       74.40     52.54                                   
REMARK 500    LEU I  68       30.83     78.81                                   
REMARK 500    ARG I 228      -14.18     67.29                                   
REMARK 500    LEU I 229       -7.29     58.25                                   
REMARK 500    PRO I 231       63.40    -66.15                                   
REMARK 500    THR I 248      -96.22   -105.93                                   
REMARK 500    SER I 271     -142.48     72.20                                   
REMARK 500    SER I 319     -116.19     57.37                                   
REMARK 500    PRO I 439       73.69    -69.05                                   
REMARK 500    ASP I 458     -129.15     50.49                                   
REMARK 500    GLN I 560      141.85   -179.46                                   
REMARK 500    PRO G 176       82.31    -66.67                                   
REMARK 500    GLN G 354       39.33   -146.25                                   
REMARK 500    GLU G 357     -107.34     10.10                                   
REMARK 500    ASP G 363       21.84   -140.04                                   
REMARK 500    LYS H 103      -54.41   -127.57                                   
REMARK 500    ARG H 228      -19.87     75.27                                   
REMARK 500    LEU H 229        8.04     58.60                                   
REMARK 500    SER H 271     -123.34     63.22                                   
REMARK 500    PHE H 273      114.25   -179.21                                   
REMARK 500    SER H 319     -129.96     68.09                                   
REMARK 500    GLU H 457      -59.64   -124.82                                   
REMARK 500    ARG H 459      -15.34     79.74                                   
REMARK 500    PHE H 460       74.99     54.84                                   
REMARK 500    ALA A  47       63.62   -151.55                                   
REMARK 500    ALA A  79       39.05   -154.01                                   
REMARK 500    ASP D 285       32.88    -94.91                                   
REMARK 500    VAL D 298      -64.08   -122.82                                   
REMARK 500    PRO B  69      -14.52    -48.84                                   
REMARK 500    ALA B  79       38.25   -153.93                                   
REMARK 500    MET B 256       74.20   -113.08                                   
REMARK 500    ALA E  47       62.55   -152.57                                   
REMARK 500    ASP E  70       21.31   -154.47                                   
REMARK 500    ALA C  79       45.23   -156.17                                   
REMARK 500    MET C 256       78.35   -113.73                                   
REMARK 500    ASP F  10     -129.43     46.02                                   
REMARK 500    ALA F  47       67.01   -154.27                                   
REMARK 500    ALA F  79      -27.75   -142.60                                   
REMARK 500    MET F 256       71.83   -117.04                                   
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: EMD-9341   RELATED DB: EMDB                              
REMARK 900 RELATED ID: EMD-9342   RELATED DB: EMDB                              
REMARK 900 RELATED ID: EMD-9343   RELATED DB: EMDB                              
DBREF  6N38 I    1   587  UNP    D3GUX3   D3GUX3_ECO44     1    587             
DBREF  6N38 G   64   366  UNP    D3GUX4   D3GUX4_ECO44    31    333             
DBREF  6N38 H    1   587  UNP    D3GUX3   D3GUX3_ECO44     1    587             
DBREF  6N38 K    1    21  PDB    6N38     6N38             1     21             
DBREF  6N38 L    1    21  PDB    6N38     6N38             1     21             
DBREF  6N38 A    1   316  UNP    D3GU39   D3GU39_ECO44     1    316             
DBREF  6N38 D    1   316  UNP    D3GU39   D3GU39_ECO44     1    316             
DBREF  6N38 B    1   316  UNP    D3GU39   D3GU39_ECO44     1    316             
DBREF  6N38 E    1   316  UNP    D3GU39   D3GU39_ECO44     1    316             
DBREF  6N38 C    1   316  UNP    D3GU39   D3GU39_ECO44     1    316             
DBREF  6N38 F    1   316  UNP    D3GU39   D3GU39_ECO44     1    316             
SEQADV 6N38 HIS A  317  UNP  D3GU39              EXPRESSION TAG                 
SEQADV 6N38 HIS A  318  UNP  D3GU39              EXPRESSION TAG                 
SEQADV 6N38 HIS A  319  UNP  D3GU39              EXPRESSION TAG                 
SEQADV 6N38 HIS A  320  UNP  D3GU39              EXPRESSION TAG                 
SEQADV 6N38 HIS A  321  UNP  D3GU39              EXPRESSION TAG                 
SEQADV 6N38 HIS A  322  UNP  D3GU39              EXPRESSION TAG                 
SEQADV 6N38 HIS D  317  UNP  D3GU39              EXPRESSION TAG                 
SEQADV 6N38 HIS D  318  UNP  D3GU39              EXPRESSION TAG                 
SEQADV 6N38 HIS D  319  UNP  D3GU39              EXPRESSION TAG                 
SEQADV 6N38 HIS D  320  UNP  D3GU39              EXPRESSION TAG                 
SEQADV 6N38 HIS D  321  UNP  D3GU39              EXPRESSION TAG                 
SEQADV 6N38 HIS D  322  UNP  D3GU39              EXPRESSION TAG                 
SEQADV 6N38 HIS B  317  UNP  D3GU39              EXPRESSION TAG                 
SEQADV 6N38 HIS B  318  UNP  D3GU39              EXPRESSION TAG                 
SEQADV 6N38 HIS B  319  UNP  D3GU39              EXPRESSION TAG                 
SEQADV 6N38 HIS B  320  UNP  D3GU39              EXPRESSION TAG                 
SEQADV 6N38 HIS B  321  UNP  D3GU39              EXPRESSION TAG                 
SEQADV 6N38 HIS B  322  UNP  D3GU39              EXPRESSION TAG                 
SEQADV 6N38 HIS E  317  UNP  D3GU39              EXPRESSION TAG                 
SEQADV 6N38 HIS E  318  UNP  D3GU39              EXPRESSION TAG                 
SEQADV 6N38 HIS E  319  UNP  D3GU39              EXPRESSION TAG                 
SEQADV 6N38 HIS E  320  UNP  D3GU39              EXPRESSION TAG                 
SEQADV 6N38 HIS E  321  UNP  D3GU39              EXPRESSION TAG                 
SEQADV 6N38 HIS E  322  UNP  D3GU39              EXPRESSION TAG                 
SEQADV 6N38 HIS C  317  UNP  D3GU39              EXPRESSION TAG                 
SEQADV 6N38 HIS C  318  UNP  D3GU39              EXPRESSION TAG                 
SEQADV 6N38 HIS C  319  UNP  D3GU39              EXPRESSION TAG                 
SEQADV 6N38 HIS C  320  UNP  D3GU39              EXPRESSION TAG                 
SEQADV 6N38 HIS C  321  UNP  D3GU39              EXPRESSION TAG                 
SEQADV 6N38 HIS C  322  UNP  D3GU39              EXPRESSION TAG                 
SEQADV 6N38 HIS F  317  UNP  D3GU39              EXPRESSION TAG                 
SEQADV 6N38 HIS F  318  UNP  D3GU39              EXPRESSION TAG                 
SEQADV 6N38 HIS F  319  UNP  D3GU39              EXPRESSION TAG                 
SEQADV 6N38 HIS F  320  UNP  D3GU39              EXPRESSION TAG                 
SEQADV 6N38 HIS F  321  UNP  D3GU39              EXPRESSION TAG                 
SEQADV 6N38 HIS F  322  UNP  D3GU39              EXPRESSION TAG                 
SEQRES   1 I  587  MET ASP ASP LEU THR LEU ARG TYR PHE ASP ALA GLU MET          
SEQRES   2 I  587  ARG TYR LEU ARG GLU ALA GLY LYS ALA PHE ALA GLN ALA          
SEQRES   3 I  587  HIS PRO ASP ARG ALA ALA MET LEU ASP LEU ASP LYS ALA          
SEQRES   4 I  587  GLY THR PRO ASP PRO CYS VAL GLU ARG LEU PHE GLU GLY          
SEQRES   5 I  587  PHE ALA PHE SER MET GLY ARG LEU ARG GLN LYS ILE ASP          
SEQRES   6 I  587  ASP ASP LEU PRO GLU LEU THR GLU SER LEU VAL SER MET          
SEQRES   7 I  587  LEU TRP PRO HIS TYR LEU ARG THR ILE PRO SER LEU SER          
SEQRES   8 I  587  VAL VAL ALA LEU THR PRO ARG LEU SER VAL MET LYS MET          
SEQRES   9 I  587  ALA GLU THR VAL PRO ALA GLY LEU GLU VAL THR SER ARG          
SEQRES  10 I  587  PRO VAL GLY PRO GLY ASN THR VAL CYS ARG TYR ARG THR          
SEQRES  11 I  587  THR ARG ALA ILE PRO LEU ASN PRO LEU ALA VAL GLU LYS          
SEQRES  12 I  587  VAL VAL MET THR THR GLU PRO ASP GLY ARG SER VAL LEU          
SEQRES  13 I  587  LYS ILE GLY PHE ALA CYS SER GLU LEU ALA ASP TRP SER          
SEQRES  14 I  587  GLN VAL ASP LEU HIS ARG LEU SER LEU TYR LEU ALA ALA          
SEQRES  15 I  587  GLU ALA PRO VAL SER SER THR LEU HIS LEU MET MET THR          
SEQRES  16 I  587  LYS ARG LEU ALA ALA LEU TYR LEU ARG LEU PRO GLY ASN          
SEQRES  17 I  587  ASP GLU ARG ILE ARG ILE ASP GLY TRP PHE SER PRO GLY          
SEQRES  18 I  587  GLY PHE ALA GLU GLU ASP ARG LEU TRP PRO LYS GLY ASP          
SEQRES  19 I  587  SER ALA PHE SER GLY TYR GLN LEU LEU LEU GLU TYR PHE          
SEQRES  20 I  587  THR PHE ARG GLU LYS PHE MET PHE VAL HIS LEU ASN GLY          
SEQRES  21 I  587  LEU GLU ASN VAL SER LEU PRO ALA GLY ILE SER GLY PHE          
SEQRES  22 I  587  ASP LEU GLU VAL VAL LEU SER GLN PRO TRP PRO ALA ASP          
SEQRES  23 I  587  LEU PRO VAL THR ASP ASP ALA LEU CYS LEU HIS CYS VAL          
SEQRES  24 I  587  PRO VAL ILE ASN LEU PHE THR LEU GLU ALA ASP PRO LEU          
SEQRES  25 I  587  ILE ILE ASN GLY LEU GLU SER GLU TYR LEU LEU ARG PRO          
SEQRES  26 I  587  LYS ARG LEU GLN ASP GLY TYR THR GLU ILE TYR SER VAL          
SEQRES  27 I  587  ASP ALA VAL THR GLY SER GLY ARG THR GLY SER ALA GLU          
SEQRES  28 I  587  TYR VAL PRO PHE THR SER PHE ARG HIS ARG GLY GLY MET          
SEQRES  29 I  587  LEU ARG HIS ASP ALA PRO GLU ARG TYR TYR HIS THR ARG          
SEQRES  30 I  587  VAL LYS ARG GLY VAL THR GLY MET TYR ASP THR TRP LEU          
SEQRES  31 I  587  ILE LEU GLY GLY GLN ARG TRP GLU ALA ASP ARG MET PRO          
SEQRES  32 I  587  GLU ARG GLU THR LEU SER LEU ARG ILE THR GLY THR ASN          
SEQRES  33 I  587  GLY GLN LEU PRO ARG ARG ALA LEU GLN SER THR LEU LEU          
SEQRES  34 I  587  ASP ARG CYS GLU GLN VAL LEU GLN ALA PRO VAL SER VAL          
SEQRES  35 I  587  ARG ASN LEU CYS LYS PRO THR LEU PRO VAL TYR PRO PRO          
SEQRES  36 I  587  THR GLU ASP ARG PHE HIS TRP ARG VAL MET SER HIS LEU          
SEQRES  37 I  587  GLY THR GLY PHE LEU ASN MET LEU SER SER ALA GLU VAL          
SEQRES  38 I  587  LEU ARG GLY THR LEU ALA LEU TYR ASN TRP ARG ASP ASP          
SEQRES  39 I  587  GLU LEU ASN HIS ARG ARG LEU ASP ALA ILE LEU ALA VAL          
SEQRES  40 I  587  GLN HIS HIS ARG ILE GLN ARG PHE GLU LYS GLY PHE LEU          
SEQRES  41 I  587  LEU ARG GLY LEU ASP VAL GLU VAL THR LEU ASP GLY ASN          
SEQRES  42 I  587  GLY PHE ALA GLY GLU GLY ASP ILE HIS LEU PHE GLY GLU          
SEQRES  43 I  587  MET LEU ASN ARG PHE LEU ALA LEU TYR ALA ASP MET ASN          
SEQRES  44 I  587  GLN PHE ASN GLN LEU THR LEU ILE VAL GLN PRO GLU GLY          
SEQRES  45 I  587  LYS CYS ILE ARG TRP LYS GLU ASN HIS ASN PRO ARG LEU          
SEQRES  46 I  587  PRO GLY                                                      
SEQRES   1 G  303  MET GLY PHE PRO ALA SER GLU ILE LYS ASP ALA VAL ILE          
SEQRES   2 G  303  PRO GLU GLU SER HIS LEU PRO PRO ILE VAL HIS VAL THR          
SEQRES   3 G  303  PHE MET GLY LEU TYR GLY VAL THR SER PRO LEU PRO ALA          
SEQRES   4 G  303  HIS TYR ILE SER ASP ILE ALA GLN GLN ARG GLU GLY HIS          
SEQRES   5 G  303  GLU ALA ALA ALA ASP PHE LEU ASP ILE PHE SER HIS ARG          
SEQRES   6 G  303  LEU ILE THR GLN TYR TYR ARG ILE TRP ARG LYS TYR SER          
SEQRES   7 G  303  TYR PRO ALA THR PHE GLU ALA GLY GLY GLN ASP LYS THR          
SEQRES   8 G  303  SER GLN TYR LEU LEU GLY LEU ALA ARG LEU GLY ILE PRO          
SEQRES   9 G  303  GLY CYS ALA GLN ASN ILE ALA THR PRO VAL SER ARG PHE          
SEQRES  10 G  303  LEU ALA LEU LEU PRO LEU MET LEU LEU PRO GLY ARG THR          
SEQRES  11 G  303  ALA GLU GLY LEU THR SER LEU VAL THR LEU LEU ALA PRO          
SEQRES  12 G  303  GLY THR GLN ALA ARG VAL TRP HIS HIS ASP ARG ARG ARG          
SEQRES  13 G  303  ILE PRO LEU LYS THR PRO LEU THR MET ARG VAL HIS HIS          
SEQRES  14 G  303  PRO VAL SER LEU LYS SER ARG PRO VAL MET GLY ASP HIS          
SEQRES  15 G  303  ALA THR ASP VAL ASN GLY GLN VAL LEU LEU GLN LEU SER          
SEQRES  16 G  303  THR GLN THR GLY SER GLU VAL GLN GLY TRP LEU PRO GLY          
SEQRES  17 G  303  GLY HIS LEU TYR SER ASP LEU LEU ALA LEU LEU HIS VAL          
SEQRES  18 G  303  TYR LEU GLY SER ARG LEU ASP VAL ARG LEU GLN LEU CYS          
SEQRES  19 G  303  VAL GLU ARG SER LEU LEU PRO ASP ALA ARG LEU SER CYS          
SEQRES  20 G  303  ARG PRO ALA ALA GLY SER PRO GLN LEU GLY ARG THR ALA          
SEQRES  21 G  303  VAL MET ARG THR GLN ALA LYS ILE ALA THR SER ALA ALA          
SEQRES  22 G  303  ARG VAL MET THR ILE SER LEU GLY ARG TYR GLN ARG VAL          
SEQRES  23 G  303  GLN GLU HIS TYR GLN ARG LYS GLU THR GLN GLU ASN GLY          
SEQRES  24 G  303  ASP TYR ARG TRP                                              
SEQRES   1 H  587  MET ASP ASP LEU THR LEU ARG TYR PHE ASP ALA GLU MET          
SEQRES   2 H  587  ARG TYR LEU ARG GLU ALA GLY LYS ALA PHE ALA GLN ALA          
SEQRES   3 H  587  HIS PRO ASP ARG ALA ALA MET LEU ASP LEU ASP LYS ALA          
SEQRES   4 H  587  GLY THR PRO ASP PRO CYS VAL GLU ARG LEU PHE GLU GLY          
SEQRES   5 H  587  PHE ALA PHE SER MET GLY ARG LEU ARG GLN LYS ILE ASP          
SEQRES   6 H  587  ASP ASP LEU PRO GLU LEU THR GLU SER LEU VAL SER MET          
SEQRES   7 H  587  LEU TRP PRO HIS TYR LEU ARG THR ILE PRO SER LEU SER          
SEQRES   8 H  587  VAL VAL ALA LEU THR PRO ARG LEU SER VAL MET LYS MET          
SEQRES   9 H  587  ALA GLU THR VAL PRO ALA GLY LEU GLU VAL THR SER ARG          
SEQRES  10 H  587  PRO VAL GLY PRO GLY ASN THR VAL CYS ARG TYR ARG THR          
SEQRES  11 H  587  THR ARG ALA ILE PRO LEU ASN PRO LEU ALA VAL GLU LYS          
SEQRES  12 H  587  VAL VAL MET THR THR GLU PRO ASP GLY ARG SER VAL LEU          
SEQRES  13 H  587  LYS ILE GLY PHE ALA CYS SER GLU LEU ALA ASP TRP SER          
SEQRES  14 H  587  GLN VAL ASP LEU HIS ARG LEU SER LEU TYR LEU ALA ALA          
SEQRES  15 H  587  GLU ALA PRO VAL SER SER THR LEU HIS LEU MET MET THR          
SEQRES  16 H  587  LYS ARG LEU ALA ALA LEU TYR LEU ARG LEU PRO GLY ASN          
SEQRES  17 H  587  ASP GLU ARG ILE ARG ILE ASP GLY TRP PHE SER PRO GLY          
SEQRES  18 H  587  GLY PHE ALA GLU GLU ASP ARG LEU TRP PRO LYS GLY ASP          
SEQRES  19 H  587  SER ALA PHE SER GLY TYR GLN LEU LEU LEU GLU TYR PHE          
SEQRES  20 H  587  THR PHE ARG GLU LYS PHE MET PHE VAL HIS LEU ASN GLY          
SEQRES  21 H  587  LEU GLU ASN VAL SER LEU PRO ALA GLY ILE SER GLY PHE          
SEQRES  22 H  587  ASP LEU GLU VAL VAL LEU SER GLN PRO TRP PRO ALA ASP          
SEQRES  23 H  587  LEU PRO VAL THR ASP ASP ALA LEU CYS LEU HIS CYS VAL          
SEQRES  24 H  587  PRO VAL ILE ASN LEU PHE THR LEU GLU ALA ASP PRO LEU          
SEQRES  25 H  587  ILE ILE ASN GLY LEU GLU SER GLU TYR LEU LEU ARG PRO          
SEQRES  26 H  587  LYS ARG LEU GLN ASP GLY TYR THR GLU ILE TYR SER VAL          
SEQRES  27 H  587  ASP ALA VAL THR GLY SER GLY ARG THR GLY SER ALA GLU          
SEQRES  28 H  587  TYR VAL PRO PHE THR SER PHE ARG HIS ARG GLY GLY MET          
SEQRES  29 H  587  LEU ARG HIS ASP ALA PRO GLU ARG TYR TYR HIS THR ARG          
SEQRES  30 H  587  VAL LYS ARG GLY VAL THR GLY MET TYR ASP THR TRP LEU          
SEQRES  31 H  587  ILE LEU GLY GLY GLN ARG TRP GLU ALA ASP ARG MET PRO          
SEQRES  32 H  587  GLU ARG GLU THR LEU SER LEU ARG ILE THR GLY THR ASN          
SEQRES  33 H  587  GLY GLN LEU PRO ARG ARG ALA LEU GLN SER THR LEU LEU          
SEQRES  34 H  587  ASP ARG CYS GLU GLN VAL LEU GLN ALA PRO VAL SER VAL          
SEQRES  35 H  587  ARG ASN LEU CYS LYS PRO THR LEU PRO VAL TYR PRO PRO          
SEQRES  36 H  587  THR GLU ASP ARG PHE HIS TRP ARG VAL MET SER HIS LEU          
SEQRES  37 H  587  GLY THR GLY PHE LEU ASN MET LEU SER SER ALA GLU VAL          
SEQRES  38 H  587  LEU ARG GLY THR LEU ALA LEU TYR ASN TRP ARG ASP ASP          
SEQRES  39 H  587  GLU LEU ASN HIS ARG ARG LEU ASP ALA ILE LEU ALA VAL          
SEQRES  40 H  587  GLN HIS HIS ARG ILE GLN ARG PHE GLU LYS GLY PHE LEU          
SEQRES  41 H  587  LEU ARG GLY LEU ASP VAL GLU VAL THR LEU ASP GLY ASN          
SEQRES  42 H  587  GLY PHE ALA GLY GLU GLY ASP ILE HIS LEU PHE GLY GLU          
SEQRES  43 H  587  MET LEU ASN ARG PHE LEU ALA LEU TYR ALA ASP MET ASN          
SEQRES  44 H  587  GLN PHE ASN GLN LEU THR LEU ILE VAL GLN PRO GLU GLY          
SEQRES  45 H  587  LYS CYS ILE ARG TRP LYS GLU ASN HIS ASN PRO ARG LEU          
SEQRES  46 H  587  PRO GLY                                                      
SEQRES   1 K   21  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES   2 K   21  UNK UNK UNK UNK UNK UNK UNK UNK                              
SEQRES   1 L   21  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES   2 L   21  UNK UNK UNK UNK UNK UNK UNK UNK                              
SEQRES   1 A  322  MET LYS ILE TYR ARG PRO LEU TRP GLU ASP GLY ALA PHE          
SEQRES   2 A  322  LEU MET PRO GLN GLN PHE GLN GLN GLN ALA ALA TRP ASP          
SEQRES   3 A  322  VAL HIS LEU ALA ASP SER VAL ALA ARG MET GLY LEU ALA          
SEQRES   4 A  322  HIS PRO TRP GLY VAL VAL ALA ALA GLU PHE ASP ASP SER          
SEQRES   5 A  322  LEU LEU PRO LEU SER ARG LEU ASN ALA THR ARG LEU ILE          
SEQRES   6 A  322  VAL ARG PHE PRO ASP GLY THR LEU ILE ASP THR GLU ARG          
SEQRES   7 A  322  ALA ASP ASN LEU PRO PRO VAL CYS ASP LEU SER THR VAL          
SEQRES   8 A  322  SER ASP ARG SER LEU VAL ASP ILE VAL LEU ALA LEU PRO          
SEQRES   9 A  322  LEU LEU ASN ALA ASN GLY GLY ASN LEU ASP ASN GLY SER          
SEQRES  10 A  322  GLU SER GLU ARG PRO ARG ARG TRP LYS SER GLU ARG VAL          
SEQRES  11 A  322  ASN VAL GLN GLU LEU ALA GLY HIS GLU GLN SER GLU VAL          
SEQRES  12 A  322  ALA VAL LEU ARG HIS ASN LEU THR LEU ARG MET ALA HIS          
SEQRES  13 A  322  GLN GLU ASN ALA ALA TRP LEU THR CYS PRO VAL THR ARG          
SEQRES  14 A  322  LEU VAL ARG ASP ALA GLN GLY GLN TRP CYS ARG ASP PRO          
SEQRES  15 A  322  ARG PHE ILE PRO PRO LEU LEU THR LEU SER ALA SER PRO          
SEQRES  16 A  322  SER LEU MET THR GLU LEU ALA GLU LEU LEU HIS HIS LEU          
SEQRES  17 A  322  GLN ALA ARG ARG GLN ARG LEU MET SER MET ARG ARG GLU          
SEQRES  18 A  322  ASN ASN ALA ARG LEU ALA ASP PHE ALA VAL ALA ASP VAL          
SEQRES  19 A  322  SER LEU PHE TRP LEU LEU ASN ALA LEU ASN SER ALA GLU          
SEQRES  20 A  322  PRO VAL LEU LYS GLU LEU LEU ASP MET PRO TYR ARG HIS          
SEQRES  21 A  322  PRO GLU LEU LEU TYR ARG GLU LEU ALA ARG LEU ALA GLY          
SEQRES  22 A  322  SER LEU LEU THR PHE SER LEU GLU HIS ASN VAL ASP ALA          
SEQRES  23 A  322  VAL PRO ALA TYR HIS HIS GLU THR PRO GLU ASN VAL PHE          
SEQRES  24 A  322  PRO PRO LEU LEU SER LEU LEU ASN ARG LEU LEU GLU ALA          
SEQRES  25 A  322  SER LEU PRO SER HIS HIS HIS HIS HIS HIS                      
SEQRES   1 D  322  MET LYS ILE TYR ARG PRO LEU TRP GLU ASP GLY ALA PHE          
SEQRES   2 D  322  LEU MET PRO GLN GLN PHE GLN GLN GLN ALA ALA TRP ASP          
SEQRES   3 D  322  VAL HIS LEU ALA ASP SER VAL ALA ARG MET GLY LEU ALA          
SEQRES   4 D  322  HIS PRO TRP GLY VAL VAL ALA ALA GLU PHE ASP ASP SER          
SEQRES   5 D  322  LEU LEU PRO LEU SER ARG LEU ASN ALA THR ARG LEU ILE          
SEQRES   6 D  322  VAL ARG PHE PRO ASP GLY THR LEU ILE ASP THR GLU ARG          
SEQRES   7 D  322  ALA ASP ASN LEU PRO PRO VAL CYS ASP LEU SER THR VAL          
SEQRES   8 D  322  SER ASP ARG SER LEU VAL ASP ILE VAL LEU ALA LEU PRO          
SEQRES   9 D  322  LEU LEU ASN ALA ASN GLY GLY ASN LEU ASP ASN GLY SER          
SEQRES  10 D  322  GLU SER GLU ARG PRO ARG ARG TRP LYS SER GLU ARG VAL          
SEQRES  11 D  322  ASN VAL GLN GLU LEU ALA GLY HIS GLU GLN SER GLU VAL          
SEQRES  12 D  322  ALA VAL LEU ARG HIS ASN LEU THR LEU ARG MET ALA HIS          
SEQRES  13 D  322  GLN GLU ASN ALA ALA TRP LEU THR CYS PRO VAL THR ARG          
SEQRES  14 D  322  LEU VAL ARG ASP ALA GLN GLY GLN TRP CYS ARG ASP PRO          
SEQRES  15 D  322  ARG PHE ILE PRO PRO LEU LEU THR LEU SER ALA SER PRO          
SEQRES  16 D  322  SER LEU MET THR GLU LEU ALA GLU LEU LEU HIS HIS LEU          
SEQRES  17 D  322  GLN ALA ARG ARG GLN ARG LEU MET SER MET ARG ARG GLU          
SEQRES  18 D  322  ASN ASN ALA ARG LEU ALA ASP PHE ALA VAL ALA ASP VAL          
SEQRES  19 D  322  SER LEU PHE TRP LEU LEU ASN ALA LEU ASN SER ALA GLU          
SEQRES  20 D  322  PRO VAL LEU LYS GLU LEU LEU ASP MET PRO TYR ARG HIS          
SEQRES  21 D  322  PRO GLU LEU LEU TYR ARG GLU LEU ALA ARG LEU ALA GLY          
SEQRES  22 D  322  SER LEU LEU THR PHE SER LEU GLU HIS ASN VAL ASP ALA          
SEQRES  23 D  322  VAL PRO ALA TYR HIS HIS GLU THR PRO GLU ASN VAL PHE          
SEQRES  24 D  322  PRO PRO LEU LEU SER LEU LEU ASN ARG LEU LEU GLU ALA          
SEQRES  25 D  322  SER LEU PRO SER HIS HIS HIS HIS HIS HIS                      
SEQRES   1 B  322  MET LYS ILE TYR ARG PRO LEU TRP GLU ASP GLY ALA PHE          
SEQRES   2 B  322  LEU MET PRO GLN GLN PHE GLN GLN GLN ALA ALA TRP ASP          
SEQRES   3 B  322  VAL HIS LEU ALA ASP SER VAL ALA ARG MET GLY LEU ALA          
SEQRES   4 B  322  HIS PRO TRP GLY VAL VAL ALA ALA GLU PHE ASP ASP SER          
SEQRES   5 B  322  LEU LEU PRO LEU SER ARG LEU ASN ALA THR ARG LEU ILE          
SEQRES   6 B  322  VAL ARG PHE PRO ASP GLY THR LEU ILE ASP THR GLU ARG          
SEQRES   7 B  322  ALA ASP ASN LEU PRO PRO VAL CYS ASP LEU SER THR VAL          
SEQRES   8 B  322  SER ASP ARG SER LEU VAL ASP ILE VAL LEU ALA LEU PRO          
SEQRES   9 B  322  LEU LEU ASN ALA ASN GLY GLY ASN LEU ASP ASN GLY SER          
SEQRES  10 B  322  GLU SER GLU ARG PRO ARG ARG TRP LYS SER GLU ARG VAL          
SEQRES  11 B  322  ASN VAL GLN GLU LEU ALA GLY HIS GLU GLN SER GLU VAL          
SEQRES  12 B  322  ALA VAL LEU ARG HIS ASN LEU THR LEU ARG MET ALA HIS          
SEQRES  13 B  322  GLN GLU ASN ALA ALA TRP LEU THR CYS PRO VAL THR ARG          
SEQRES  14 B  322  LEU VAL ARG ASP ALA GLN GLY GLN TRP CYS ARG ASP PRO          
SEQRES  15 B  322  ARG PHE ILE PRO PRO LEU LEU THR LEU SER ALA SER PRO          
SEQRES  16 B  322  SER LEU MET THR GLU LEU ALA GLU LEU LEU HIS HIS LEU          
SEQRES  17 B  322  GLN ALA ARG ARG GLN ARG LEU MET SER MET ARG ARG GLU          
SEQRES  18 B  322  ASN ASN ALA ARG LEU ALA ASP PHE ALA VAL ALA ASP VAL          
SEQRES  19 B  322  SER LEU PHE TRP LEU LEU ASN ALA LEU ASN SER ALA GLU          
SEQRES  20 B  322  PRO VAL LEU LYS GLU LEU LEU ASP MET PRO TYR ARG HIS          
SEQRES  21 B  322  PRO GLU LEU LEU TYR ARG GLU LEU ALA ARG LEU ALA GLY          
SEQRES  22 B  322  SER LEU LEU THR PHE SER LEU GLU HIS ASN VAL ASP ALA          
SEQRES  23 B  322  VAL PRO ALA TYR HIS HIS GLU THR PRO GLU ASN VAL PHE          
SEQRES  24 B  322  PRO PRO LEU LEU SER LEU LEU ASN ARG LEU LEU GLU ALA          
SEQRES  25 B  322  SER LEU PRO SER HIS HIS HIS HIS HIS HIS                      
SEQRES   1 E  322  MET LYS ILE TYR ARG PRO LEU TRP GLU ASP GLY ALA PHE          
SEQRES   2 E  322  LEU MET PRO GLN GLN PHE GLN GLN GLN ALA ALA TRP ASP          
SEQRES   3 E  322  VAL HIS LEU ALA ASP SER VAL ALA ARG MET GLY LEU ALA          
SEQRES   4 E  322  HIS PRO TRP GLY VAL VAL ALA ALA GLU PHE ASP ASP SER          
SEQRES   5 E  322  LEU LEU PRO LEU SER ARG LEU ASN ALA THR ARG LEU ILE          
SEQRES   6 E  322  VAL ARG PHE PRO ASP GLY THR LEU ILE ASP THR GLU ARG          
SEQRES   7 E  322  ALA ASP ASN LEU PRO PRO VAL CYS ASP LEU SER THR VAL          
SEQRES   8 E  322  SER ASP ARG SER LEU VAL ASP ILE VAL LEU ALA LEU PRO          
SEQRES   9 E  322  LEU LEU ASN ALA ASN GLY GLY ASN LEU ASP ASN GLY SER          
SEQRES  10 E  322  GLU SER GLU ARG PRO ARG ARG TRP LYS SER GLU ARG VAL          
SEQRES  11 E  322  ASN VAL GLN GLU LEU ALA GLY HIS GLU GLN SER GLU VAL          
SEQRES  12 E  322  ALA VAL LEU ARG HIS ASN LEU THR LEU ARG MET ALA HIS          
SEQRES  13 E  322  GLN GLU ASN ALA ALA TRP LEU THR CYS PRO VAL THR ARG          
SEQRES  14 E  322  LEU VAL ARG ASP ALA GLN GLY GLN TRP CYS ARG ASP PRO          
SEQRES  15 E  322  ARG PHE ILE PRO PRO LEU LEU THR LEU SER ALA SER PRO          
SEQRES  16 E  322  SER LEU MET THR GLU LEU ALA GLU LEU LEU HIS HIS LEU          
SEQRES  17 E  322  GLN ALA ARG ARG GLN ARG LEU MET SER MET ARG ARG GLU          
SEQRES  18 E  322  ASN ASN ALA ARG LEU ALA ASP PHE ALA VAL ALA ASP VAL          
SEQRES  19 E  322  SER LEU PHE TRP LEU LEU ASN ALA LEU ASN SER ALA GLU          
SEQRES  20 E  322  PRO VAL LEU LYS GLU LEU LEU ASP MET PRO TYR ARG HIS          
SEQRES  21 E  322  PRO GLU LEU LEU TYR ARG GLU LEU ALA ARG LEU ALA GLY          
SEQRES  22 E  322  SER LEU LEU THR PHE SER LEU GLU HIS ASN VAL ASP ALA          
SEQRES  23 E  322  VAL PRO ALA TYR HIS HIS GLU THR PRO GLU ASN VAL PHE          
SEQRES  24 E  322  PRO PRO LEU LEU SER LEU LEU ASN ARG LEU LEU GLU ALA          
SEQRES  25 E  322  SER LEU PRO SER HIS HIS HIS HIS HIS HIS                      
SEQRES   1 C  322  MET LYS ILE TYR ARG PRO LEU TRP GLU ASP GLY ALA PHE          
SEQRES   2 C  322  LEU MET PRO GLN GLN PHE GLN GLN GLN ALA ALA TRP ASP          
SEQRES   3 C  322  VAL HIS LEU ALA ASP SER VAL ALA ARG MET GLY LEU ALA          
SEQRES   4 C  322  HIS PRO TRP GLY VAL VAL ALA ALA GLU PHE ASP ASP SER          
SEQRES   5 C  322  LEU LEU PRO LEU SER ARG LEU ASN ALA THR ARG LEU ILE          
SEQRES   6 C  322  VAL ARG PHE PRO ASP GLY THR LEU ILE ASP THR GLU ARG          
SEQRES   7 C  322  ALA ASP ASN LEU PRO PRO VAL CYS ASP LEU SER THR VAL          
SEQRES   8 C  322  SER ASP ARG SER LEU VAL ASP ILE VAL LEU ALA LEU PRO          
SEQRES   9 C  322  LEU LEU ASN ALA ASN GLY GLY ASN LEU ASP ASN GLY SER          
SEQRES  10 C  322  GLU SER GLU ARG PRO ARG ARG TRP LYS SER GLU ARG VAL          
SEQRES  11 C  322  ASN VAL GLN GLU LEU ALA GLY HIS GLU GLN SER GLU VAL          
SEQRES  12 C  322  ALA VAL LEU ARG HIS ASN LEU THR LEU ARG MET ALA HIS          
SEQRES  13 C  322  GLN GLU ASN ALA ALA TRP LEU THR CYS PRO VAL THR ARG          
SEQRES  14 C  322  LEU VAL ARG ASP ALA GLN GLY GLN TRP CYS ARG ASP PRO          
SEQRES  15 C  322  ARG PHE ILE PRO PRO LEU LEU THR LEU SER ALA SER PRO          
SEQRES  16 C  322  SER LEU MET THR GLU LEU ALA GLU LEU LEU HIS HIS LEU          
SEQRES  17 C  322  GLN ALA ARG ARG GLN ARG LEU MET SER MET ARG ARG GLU          
SEQRES  18 C  322  ASN ASN ALA ARG LEU ALA ASP PHE ALA VAL ALA ASP VAL          
SEQRES  19 C  322  SER LEU PHE TRP LEU LEU ASN ALA LEU ASN SER ALA GLU          
SEQRES  20 C  322  PRO VAL LEU LYS GLU LEU LEU ASP MET PRO TYR ARG HIS          
SEQRES  21 C  322  PRO GLU LEU LEU TYR ARG GLU LEU ALA ARG LEU ALA GLY          
SEQRES  22 C  322  SER LEU LEU THR PHE SER LEU GLU HIS ASN VAL ASP ALA          
SEQRES  23 C  322  VAL PRO ALA TYR HIS HIS GLU THR PRO GLU ASN VAL PHE          
SEQRES  24 C  322  PRO PRO LEU LEU SER LEU LEU ASN ARG LEU LEU GLU ALA          
SEQRES  25 C  322  SER LEU PRO SER HIS HIS HIS HIS HIS HIS                      
SEQRES   1 F  322  MET LYS ILE TYR ARG PRO LEU TRP GLU ASP GLY ALA PHE          
SEQRES   2 F  322  LEU MET PRO GLN GLN PHE GLN GLN GLN ALA ALA TRP ASP          
SEQRES   3 F  322  VAL HIS LEU ALA ASP SER VAL ALA ARG MET GLY LEU ALA          
SEQRES   4 F  322  HIS PRO TRP GLY VAL VAL ALA ALA GLU PHE ASP ASP SER          
SEQRES   5 F  322  LEU LEU PRO LEU SER ARG LEU ASN ALA THR ARG LEU ILE          
SEQRES   6 F  322  VAL ARG PHE PRO ASP GLY THR LEU ILE ASP THR GLU ARG          
SEQRES   7 F  322  ALA ASP ASN LEU PRO PRO VAL CYS ASP LEU SER THR VAL          
SEQRES   8 F  322  SER ASP ARG SER LEU VAL ASP ILE VAL LEU ALA LEU PRO          
SEQRES   9 F  322  LEU LEU ASN ALA ASN GLY GLY ASN LEU ASP ASN GLY SER          
SEQRES  10 F  322  GLU SER GLU ARG PRO ARG ARG TRP LYS SER GLU ARG VAL          
SEQRES  11 F  322  ASN VAL GLN GLU LEU ALA GLY HIS GLU GLN SER GLU VAL          
SEQRES  12 F  322  ALA VAL LEU ARG HIS ASN LEU THR LEU ARG MET ALA HIS          
SEQRES  13 F  322  GLN GLU ASN ALA ALA TRP LEU THR CYS PRO VAL THR ARG          
SEQRES  14 F  322  LEU VAL ARG ASP ALA GLN GLY GLN TRP CYS ARG ASP PRO          
SEQRES  15 F  322  ARG PHE ILE PRO PRO LEU LEU THR LEU SER ALA SER PRO          
SEQRES  16 F  322  SER LEU MET THR GLU LEU ALA GLU LEU LEU HIS HIS LEU          
SEQRES  17 F  322  GLN ALA ARG ARG GLN ARG LEU MET SER MET ARG ARG GLU          
SEQRES  18 F  322  ASN ASN ALA ARG LEU ALA ASP PHE ALA VAL ALA ASP VAL          
SEQRES  19 F  322  SER LEU PHE TRP LEU LEU ASN ALA LEU ASN SER ALA GLU          
SEQRES  20 F  322  PRO VAL LEU LYS GLU LEU LEU ASP MET PRO TYR ARG HIS          
SEQRES  21 F  322  PRO GLU LEU LEU TYR ARG GLU LEU ALA ARG LEU ALA GLY          
SEQRES  22 F  322  SER LEU LEU THR PHE SER LEU GLU HIS ASN VAL ASP ALA          
SEQRES  23 F  322  VAL PRO ALA TYR HIS HIS GLU THR PRO GLU ASN VAL PHE          
SEQRES  24 F  322  PRO PRO LEU LEU SER LEU LEU ASN ARG LEU LEU GLU ALA          
SEQRES  25 F  322  SER LEU PRO SER HIS HIS HIS HIS HIS HIS                      
HELIX    1 AA1 GLU I   47  ASP I   67  1                                  21    
HELIX    2 AA2 LEU I   68  SER I   77  1                                  10    
HELIX    3 AA3 GLU I  183  LYS I  196  1                                  14    
HELIX    4 AA4 PHE I  237  THR I  248  1                                  12    
HELIX    5 AA5 PHE I  249  PHE I  253  5                                   5    
HELIX    6 AA6 LEU I  261  VAL I  264  5                                   4    
HELIX    7 AA7 THR I  290  ASP I  292  5                                   3    
HELIX    8 AA8 ARG I  327  GLY I  331  5                                   5    
HELIX    9 AA9 PHE I  355  HIS I  360  1                                   6    
HELIX   10 AB1 MET I  364  ALA I  369  1                                   6    
HELIX   11 AB2 PRO I  420  SER I  426  1                                   7    
HELIX   12 AB3 ARG I  459  GLY I  469  1                                  11    
HELIX   13 AB4 THR I  470  LEU I  476  5                                   7    
HELIX   14 AB5 SER I  478  ALA I  487  1                                  10    
HELIX   15 AB6 LEU I  488  ASN I  490  5                                   3    
HELIX   16 AB7 ASP I  494  ASP I  502  1                                   9    
HELIX   17 AB8 GLY I  532  PHE I  535  5                                   4    
HELIX   18 AB9 ALA I  536  ALA I  553  1                                  18    
HELIX   19 AC1 LEU I  554  ALA I  556  5                                   3    
HELIX   20 AC2 ASP G  123  TYR G  140  1                                  18    
HELIX   21 AC3 SER G  141  PHE G  146  5                                   6    
HELIX   22 AC4 ASP G  152  ALA G  162  1                                  11    
HELIX   23 AC5 CYS G  169  ILE G  173  5                                   5    
HELIX   24 AC6 PRO G  176  MET G  187  5                                  12    
HELIX   25 AC7 THR G  193  ALA G  205  1                                  13    
HELIX   26 AC8 SER G  235  ARG G  239  5                                   5    
HELIX   27 AC9 THR G  261  LEU G  269  1                                   9    
HELIX   28 AD1 GLY G  272  LEU G  286  1                                  15    
HELIX   29 AD2 SER G  301  LEU G  303  5                                   3    
HELIX   30 AD3 VAL H   46  ASP H   65  1                                  20    
HELIX   31 AD4 ASP H   67  TRP H   80  1                                  14    
HELIX   32 AD5 GLY H  120  THR H  124  5                                   5    
HELIX   33 AD6 GLU H  183  ARG H  197  1                                  15    
HELIX   34 AD7 PHE H  237  PHE H  249  1                                  13    
HELIX   35 AD8 ARG H  250  PHE H  253  5                                   4    
HELIX   36 AD9 LEU H  261  VAL H  264  5                                   4    
HELIX   37 AE1 THR H  290  ASP H  292  5                                   3    
HELIX   38 AE2 ARG H  359  MET H  364  1                                   6    
HELIX   39 AE3 PRO H  420  GLN H  425  1                                   6    
HELIX   40 AE4 PHE H  460  GLY H  471  1                                  12    
HELIX   41 AE5 SER H  478  LEU H  488  1                                  11    
HELIX   42 AE6 ASP H  494  ASP H  502  1                                   9    
HELIX   43 AE7 GLY H  532  PHE H  535  5                                   4    
HELIX   44 AE8 ALA H  536  LEU H  554  1                                  19    
HELIX   45 AE9 UNK K    2  UNK K   20  1                                  19    
HELIX   46 AF1 UNK L    2  UNK L   18  1                                  17    
HELIX   47 AF2 MET A   15  ARG A   35  1                                  21    
HELIX   48 AF3 ASP A   51  LEU A   56  5                                   6    
HELIX   49 AF4 SER A   89  SER A   92  5                                   4    
HELIX   50 AF5 THR A  190  ALA A  193  5                                   4    
HELIX   51 AF6 SER A  194  ARG A  219  1                                  26    
HELIX   52 AF7 ASP A  233  MET A  256  1                                  24    
HELIX   53 AF8 HIS A  260  LEU A  276  1                                  17    
HELIX   54 AF9 ASN A  283  VAL A  287  5                                   5    
HELIX   55 AG1 THR A  294  ASN A  297  5                                   4    
HELIX   56 AG2 VAL A  298  ALA A  312  1                                  15    
HELIX   57 AG3 MET D   15  ARG D   35  1                                  21    
HELIX   58 AG4 ASP D   51  LEU D   56  5                                   6    
HELIX   59 AG5 SER D   89  SER D   92  5                                   4    
HELIX   60 AG6 THR D  190  ALA D  193  5                                   4    
HELIX   61 AG7 SER D  194  SER D  217  1                                  24    
HELIX   62 AG8 ASP D  233  MET D  256  1                                  24    
HELIX   63 AG9 PRO D  261  LEU D  276  1                                  16    
HELIX   64 AH1 THR D  294  ASN D  297  5                                   4    
HELIX   65 AH2 VAL D  298  ALA D  312  1                                  15    
HELIX   66 AH3 MET B   15  ARG B   35  1                                  21    
HELIX   67 AH4 ASP B   51  LEU B   56  5                                   6    
HELIX   68 AH5 SER B   89  SER B   92  5                                   4    
HELIX   69 AH6 THR B  190  ALA B  193  5                                   4    
HELIX   70 AH7 SER B  194  MET B  218  1                                  25    
HELIX   71 AH8 VAL B  234  MET B  256  1                                  23    
HELIX   72 AH9 HIS B  260  LEU B  276  1                                  17    
HELIX   73 AI1 THR B  294  ASN B  297  5                                   4    
HELIX   74 AI2 VAL B  298  ALA B  312  1                                  15    
HELIX   75 AI3 MET E   15  ARG E   35  1                                  21    
HELIX   76 AI4 LEU E   53  LEU E   56  5                                   4    
HELIX   77 AI5 SER E   89  VAL E   91  5                                   3    
HELIX   78 AI6 THR E  190  ALA E  193  5                                   4    
HELIX   79 AI7 SER E  194  MET E  218  1                                  25    
HELIX   80 AI8 ASP E  233  MET E  256  1                                  24    
HELIX   81 AI9 HIS E  260  LEU E  276  1                                  17    
HELIX   82 AJ1 ASN E  283  VAL E  287  5                                   5    
HELIX   83 AJ2 THR E  294  ASN E  297  5                                   4    
HELIX   84 AJ3 VAL E  298  GLU E  311  1                                  14    
HELIX   85 AJ4 MET C   15  ARG C   35  1                                  21    
HELIX   86 AJ5 ASP C   51  LEU C   56  5                                   6    
HELIX   87 AJ6 SER C   89  SER C   92  5                                   4    
HELIX   88 AJ7 THR C  190  ALA C  193  5                                   4    
HELIX   89 AJ8 SER C  194  MET C  218  1                                  25    
HELIX   90 AJ9 ASP C  233  MET C  256  1                                  24    
HELIX   91 AK1 HIS C  260  LEU C  276  1                                  17    
HELIX   92 AK2 ASN C  283  VAL C  287  5                                   5    
HELIX   93 AK3 THR C  294  ASN C  297  5                                   4    
HELIX   94 AK4 VAL C  298  ALA C  312  1                                  15    
HELIX   95 AK5 MET F   15  ARG F   35  1                                  21    
HELIX   96 AK6 ASP F   51  LEU F   56  5                                   6    
HELIX   97 AK7 SER F   89  SER F   92  5                                   4    
HELIX   98 AK8 THR F  190  ALA F  193  5                                   4    
HELIX   99 AK9 SER F  194  ARG F  219  1                                  26    
HELIX  100 AL1 ASP F  233  MET F  256  1                                  24    
HELIX  101 AL2 HIS F  260  LEU F  276  1                                  17    
HELIX  102 AL3 THR F  294  ASN F  297  5                                   4    
HELIX  103 AL4 VAL F  298  SER F  313  1                                  16    
SHEET    1 AA1 6 LEU I 429  CYS I 432  0                                        
SHEET    2 AA1 6 GLU I 113  SER I 116 -1  N  THR I 115   O  ASP I 430           
SHEET    3 AA1 6 ARG I 127  THR I 130 -1  O  TYR I 128   N  VAL I 114           
SHEET    4 AA1 6 CYS I 298  ILE I 302 -1  O  ILE I 302   N  ARG I 129           
SHEET    5 AA1 6 LEU I  90  THR I  96 -1  N  SER I  91   O  VAL I 301           
SHEET    6 AA1 6 SER I 441  ASN I 444 -1  O  ARG I 443   N  ALA I  94           
SHEET    1 AA2 2 GLU I 106  VAL I 108  0                                        
SHEET    2 AA2 2 ILE I 134  LEU I 136 -1  O  ILE I 134   N  VAL I 108           
SHEET    1 AA3 4 LEU I 139  THR I 148  0                                        
SHEET    2 AA3 4 SER I 154  CYS I 162 -1  O  LYS I 157   N  VAL I 145           
SHEET    3 AA3 4 SER I 271  LEU I 279 -1  O  PHE I 273   N  PHE I 160           
SHEET    4 AA3 4 LEU I 198  ARG I 204 -1  N  ARG I 204   O  ASP I 274           
SHEET    1 AA4 4 TRP I 217  PRO I 220  0                                        
SHEET    2 AA4 4 PHE I 255  ASN I 259 -1  O  HIS I 257   N  SER I 219           
SHEET    3 AA4 4 ARG I 175  LEU I 180 -1  N  LEU I 178   O  VAL I 256           
SHEET    4 AA4 4 LEU I 294  CYS I 295 -1  O  CYS I 295   N  TYR I 179           
SHEET    1 AA5 3 PHE I 305  LEU I 307  0                                        
SHEET    2 AA5 3 THR I 407  ASN I 416 -1  O  GLY I 414   N  PHE I 305           
SHEET    3 AA5 3 PRO I 311  ILE I 313 -1  N  LEU I 312   O  LEU I 408           
SHEET    1 AA6 4 PHE I 305  LEU I 307  0                                        
SHEET    2 AA6 4 THR I 407  ASN I 416 -1  O  GLY I 414   N  PHE I 305           
SHEET    3 AA6 4 THR I 333  GLY I 345 -1  N  ASP I 339   O  ARG I 411           
SHEET    4 AA6 4 GLY I 348  GLU I 351 -1  O  GLY I 348   N  GLY I 345           
SHEET    1 AA7 4 TYR I 321  LEU I 323  0                                        
SHEET    2 AA7 4 TYR I 386  ILE I 391 -1  O  THR I 388   N  LEU I 323           
SHEET    3 AA7 4 TYR I 373  ARG I 380 -1  N  HIS I 375   O  ILE I 391           
SHEET    4 AA7 4 VAL I 353  PRO I 354  1  N  VAL I 353   O  TYR I 374           
SHEET    1 AA8 5 ILE I 504  GLU I 516  0                                        
SHEET    2 AA8 5 PHE I 519  LEU I 530 -1  O  LEU I 521   N  ARG I 514           
SHEET    3 AA8 5 PHE I 561  VAL I 568  1  O  ILE I 567   N  LEU I 530           
SHEET    4 AA8 5 LYS I 573  ARG I 576 -1  O  ILE I 575   N  LEU I 566           
SHEET    5 AA8 5 GLU G 360  ASN G 361  1  O  GLU G 360   N  ARG I 576           
SHEET    1 AA9 4 GLN G 209  PRO G 221  0                                        
SHEET    2 AA9 4 HIS G 245  SER G 258 -1  O  ALA G 246   N  ILE G 220           
SHEET    3 AA9 4 ASP G 291  GLU G 299  1  O  CYS G 297   N  LEU G 257           
SHEET    4 AA9 4 VAL G 338  TYR G 346 -1  O  MET G 339   N  VAL G 298           
SHEET    1 AB1 6 LEU H 429  CYS H 432  0                                        
SHEET    2 AB1 6 GLU H 113  SER H 116 -1  N  THR H 115   O  ASP H 430           
SHEET    3 AB1 6 ARG H 127  THR H 130 -1  O  TYR H 128   N  VAL H 114           
SHEET    4 AB1 6 CYS H 298  ILE H 302 -1  O  ILE H 302   N  ARG H 129           
SHEET    5 AB1 6 LEU H  90  PRO H  97 -1  N  SER H  91   O  VAL H 301           
SHEET    6 AB1 6 VAL H 440  ASN H 444 -1  O  ARG H 443   N  ALA H  94           
SHEET    1 AB2 2 GLU H 106  VAL H 108  0                                        
SHEET    2 AB2 2 ILE H 134  LEU H 136 -1  O  LEU H 136   N  GLU H 106           
SHEET    1 AB3 5 LEU H 139  THR H 148  0                                        
SHEET    2 AB3 5 SER H 154  CYS H 162 -1  O  LYS H 157   N  VAL H 145           
SHEET    3 AB3 5 ASP H 274  LEU H 279 -1  O  VAL H 277   N  LEU H 156           
SHEET    4 AB3 5 LEU H 198  ARG H 204 -1  N  ARG H 204   O  ASP H 274           
SHEET    5 AB3 5 ARG H 213  ILE H 214 -1  O  ILE H 214   N  LEU H 201           
SHEET    1 AB4 4 TRP H 217  PRO H 220  0                                        
SHEET    2 AB4 4 PHE H 255  ASN H 259 -1  O  HIS H 257   N  SER H 219           
SHEET    3 AB4 4 ARG H 175  LEU H 180 -1  N  LEU H 178   O  VAL H 256           
SHEET    4 AB4 4 LEU H 294  CYS H 295 -1  O  CYS H 295   N  TYR H 179           
SHEET    1 AB5 3 PHE H 305  THR H 306  0                                        
SHEET    2 AB5 3 THR H 407  ASN H 416 -1  O  GLY H 414   N  PHE H 305           
SHEET    3 AB5 3 LEU H 312  ILE H 313 -1  N  LEU H 312   O  LEU H 408           
SHEET    1 AB6 4 PHE H 305  THR H 306  0                                        
SHEET    2 AB6 4 THR H 407  ASN H 416 -1  O  GLY H 414   N  PHE H 305           
SHEET    3 AB6 4 THR H 333  GLY H 345 -1  N  GLU H 334   O  THR H 415           
SHEET    4 AB6 4 GLY H 348  GLU H 351 -1  O  ALA H 350   N  GLY H 343           
SHEET    1 AB7 4 GLU H 320  LEU H 322  0                                        
SHEET    2 AB7 4 TYR H 386  ILE H 391 -1  O  LEU H 390   N  TYR H 321           
SHEET    3 AB7 4 TYR H 373  ARG H 380 -1  N  ARG H 377   O  TRP H 389           
SHEET    4 AB7 4 VAL H 353  PRO H 354  1  N  VAL H 353   O  TYR H 374           
SHEET    1 AB8 4 ILE H 504  GLU H 516  0                                        
SHEET    2 AB8 4 PHE H 519  LEU H 530 -1  O  ASP H 525   N  HIS H 510           
SHEET    3 AB8 4 PHE H 561  VAL H 568  1  O  ILE H 567   N  LEU H 530           
SHEET    4 AB8 4 CYS H 574  TRP H 577 -1  O  TRP H 577   N  LEU H 564           
SHEET    1 AB9 3 GLY A  43  PHE A  49  0                                        
SHEET    2 AB9 3 ALA A  61  ARG A  67 -1  O  THR A  62   N  GLU A  48           
SHEET    3 AB9 3 LEU A  73  ASP A  75 -1  O  ILE A  74   N  VAL A  66           
SHEET    1 AC1 2 ARG A  58  LEU A  59  0                                        
SHEET    2 AC1 2 CYS A  86  ASP A  87 -1  O  CYS A  86   N  LEU A  59           
SHEET    1 AC2 4 THR A 151  MET A 154  0                                        
SHEET    2 AC2 4 LEU A  96  PRO A 104 -1  N  ALA A 102   O  THR A 151           
SHEET    3 AC2 4 TRP A 162  ARG A 172 -1  O  LEU A 163   N  LEU A 103           
SHEET    4 AC2 4 TRP A 178  ARG A 180 -1  O  CYS A 179   N  VAL A 171           
SHEET    1 AC3 2 TRP A 125  GLN A 133  0                                        
SHEET    2 AC3 2 GLN A 140  HIS A 148 -1  O  VAL A 145   N  GLU A 128           
SHEET    1 AC4 3 GLY D  43  ASP D  50  0                                        
SHEET    2 AC4 3 ARG D  58  ARG D  67 -1  O  THR D  62   N  GLU D  48           
SHEET    3 AC4 3 LEU D  73  ASP D  75 -1  O  ILE D  74   N  VAL D  66           
SHEET    1 AC5 3 GLY D  43  ASP D  50  0                                        
SHEET    2 AC5 3 ARG D  58  ARG D  67 -1  O  THR D  62   N  GLU D  48           
SHEET    3 AC5 3 CYS D  86  ASP D  87 -1  O  CYS D  86   N  LEU D  59           
SHEET    1 AC6 4 THR D 151  MET D 154  0                                        
SHEET    2 AC6 4 LEU D  96  PRO D 104 -1  N  ALA D 102   O  THR D 151           
SHEET    3 AC6 4 TRP D 162  ARG D 172 -1  O  LEU D 163   N  LEU D 103           
SHEET    4 AC6 4 TRP D 178  ARG D 180 -1  O  CYS D 179   N  VAL D 171           
SHEET    1 AC7 2 TRP D 125  GLN D 133  0                                        
SHEET    2 AC7 2 GLN D 140  HIS D 148 -1  O  SER D 141   N  VAL D 132           
SHEET    1 AC8 3 GLY B  43  ASP B  50  0                                        
SHEET    2 AC8 3 ARG B  58  ARG B  67 -1  O  ASN B  60   N  ASP B  50           
SHEET    3 AC8 3 LEU B  73  ASP B  75 -1  O  ILE B  74   N  VAL B  66           
SHEET    1 AC9 3 GLY B  43  ASP B  50  0                                        
SHEET    2 AC9 3 ARG B  58  ARG B  67 -1  O  ASN B  60   N  ASP B  50           
SHEET    3 AC9 3 CYS B  86  ASP B  87 -1  O  CYS B  86   N  LEU B  59           
SHEET    1 AD1 4 THR B 151  MET B 154  0                                        
SHEET    2 AD1 4 LEU B  96  PRO B 104 -1  N  ALA B 102   O  THR B 151           
SHEET    3 AD1 4 TRP B 162  ARG B 172 -1  O  LEU B 163   N  LEU B 103           
SHEET    4 AD1 4 TRP B 178  ARG B 180 -1  O  CYS B 179   N  VAL B 171           
SHEET    1 AD2 2 TRP B 125  GLN B 133  0                                        
SHEET    2 AD2 2 GLN B 140  HIS B 148 -1  O  SER B 141   N  VAL B 132           
SHEET    1 AD3 3 GLY E  43  ASP E  50  0                                        
SHEET    2 AD3 3 ARG E  58  ARG E  67 -1  O  THR E  62   N  GLU E  48           
SHEET    3 AD3 3 LEU E  73  ASP E  75 -1  O  ILE E  74   N  VAL E  66           
SHEET    1 AD4 3 GLY E  43  ASP E  50  0                                        
SHEET    2 AD4 3 ARG E  58  ARG E  67 -1  O  THR E  62   N  GLU E  48           
SHEET    3 AD4 3 CYS E  86  ASP E  87 -1  O  CYS E  86   N  LEU E  59           
SHEET    1 AD5 4 THR E 151  MET E 154  0                                        
SHEET    2 AD5 4 LEU E  96  PRO E 104 -1  N  ALA E 102   O  THR E 151           
SHEET    3 AD5 4 TRP E 162  ARG E 172 -1  O  LEU E 163   N  LEU E 103           
SHEET    4 AD5 4 TRP E 178  ARG E 180 -1  O  CYS E 179   N  VAL E 171           
SHEET    1 AD6 2 TRP E 125  GLN E 133  0                                        
SHEET    2 AD6 2 GLN E 140  HIS E 148 -1  O  VAL E 145   N  GLU E 128           
SHEET    1 AD7 3 GLY C  43  ASP C  50  0                                        
SHEET    2 AD7 3 ARG C  58  ARG C  67 -1  O  ILE C  65   N  VAL C  45           
SHEET    3 AD7 3 LEU C  73  ASP C  75 -1  O  ILE C  74   N  VAL C  66           
SHEET    1 AD8 3 GLY C  43  ASP C  50  0                                        
SHEET    2 AD8 3 ARG C  58  ARG C  67 -1  O  ILE C  65   N  VAL C  45           
SHEET    3 AD8 3 CYS C  86  ASP C  87 -1  O  CYS C  86   N  LEU C  59           
SHEET    1 AD9 4 THR C 151  MET C 154  0                                        
SHEET    2 AD9 4 LEU C  96  PRO C 104 -1  N  ALA C 102   O  THR C 151           
SHEET    3 AD9 4 TRP C 162  ARG C 172 -1  O  LEU C 163   N  LEU C 103           
SHEET    4 AD9 4 TRP C 178  ARG C 180 -1  O  CYS C 179   N  VAL C 171           
SHEET    1 AE1 2 TRP C 125  GLN C 133  0                                        
SHEET    2 AE1 2 GLN C 140  HIS C 148 -1  O  VAL C 145   N  GLU C 128           
SHEET    1 AE2 3 GLY F  43  ASP F  50  0                                        
SHEET    2 AE2 3 ARG F  58  ARG F  67 -1  O  THR F  62   N  GLU F  48           
SHEET    3 AE2 3 LEU F  73  ASP F  75 -1  O  ILE F  74   N  VAL F  66           
SHEET    1 AE3 3 GLY F  43  ASP F  50  0                                        
SHEET    2 AE3 3 ARG F  58  ARG F  67 -1  O  THR F  62   N  GLU F  48           
SHEET    3 AE3 3 CYS F  86  ASP F  87 -1  O  CYS F  86   N  LEU F  59           
SHEET    1 AE4 4 THR F 151  MET F 154  0                                        
SHEET    2 AE4 4 LEU F  96  PRO F 104 -1  N  ALA F 102   O  THR F 151           
SHEET    3 AE4 4 TRP F 162  ARG F 172 -1  O  LEU F 163   N  LEU F 103           
SHEET    4 AE4 4 TRP F 178  ARG F 180 -1  O  CYS F 179   N  VAL F 171           
SHEET    1 AE5 2 TRP F 125  GLN F 133  0                                        
SHEET    2 AE5 2 GLN F 140  HIS F 148 -1  O  VAL F 145   N  GLU F 128           
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1           1          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      1.000000  0.000000  0.000000        0.00000                         
SCALE2      0.000000  1.000000  0.000000        0.00000                         
SCALE3      0.000000  0.000000  1.000000        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
DBGET integrated database retrieval system