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Database: PDB
Entry: 6O85
LinkDB: 6O85
Original site: 6O85 
HEADER    TRANSLATION                             08-MAR-19   6O85              
TITLE     ELECTRON CRYO-MICROSCOPY OF THE EUKARYOTIC TRANSLATION INITIATION     
TITLE    2 FACTOR 2B BOUND TO EUKARYOTIC TRANSLATION INITIATION FACTOR 2 FROM   
TITLE    3 HOMO SAPIENS                                                         
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON;      
COMPND   3 CHAIN: A, B;                                                         
COMPND   4 SYNONYM: EIF-2B GDP-GTP EXCHANGE FACTOR SUBUNIT EPSILON;             
COMPND   5 ENGINEERED: YES;                                                     
COMPND   6 MOL_ID: 2;                                                           
COMPND   7 MOLECULE: TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA;         
COMPND   8 CHAIN: C, D;                                                         
COMPND   9 SYNONYM: S20I15,S20III15,EIF-2B GDP-GTP EXCHANGE FACTOR SUBUNIT BETA;
COMPND  10 ENGINEERED: YES;                                                     
COMPND  11 MOL_ID: 3;                                                           
COMPND  12 MOLECULE: TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT DELTA;        
COMPND  13 CHAIN: E, F;                                                         
COMPND  14 SYNONYM: EIF-2B GDP-GTP EXCHANGE FACTOR SUBUNIT DELTA;               
COMPND  15 ENGINEERED: YES;                                                     
COMPND  16 MOL_ID: 4;                                                           
COMPND  17 MOLECULE: TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA;        
COMPND  18 CHAIN: G, H;                                                         
COMPND  19 SYNONYM: EIF-2B GDP-GTP EXCHANGE FACTOR SUBUNIT ALPHA;               
COMPND  20 ENGINEERED: YES;                                                     
COMPND  21 MOL_ID: 5;                                                           
COMPND  22 MOLECULE: TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA;        
COMPND  23 CHAIN: I, J;                                                         
COMPND  24 SYNONYM: EIF-2B GDP-GTP EXCHANGE FACTOR SUBUNIT GAMMA;               
COMPND  25 ENGINEERED: YES;                                                     
COMPND  26 MOL_ID: 6;                                                           
COMPND  27 MOLECULE: EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1;      
COMPND  28 CHAIN: L;                                                            
COMPND  29 SYNONYM: EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT ALPHA,   
COMPND  30 EIF-2ALPHA;                                                          
COMPND  31 ENGINEERED: YES;                                                     
COMPND  32 MOL_ID: 7;                                                           
COMPND  33 MOLECULE: EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3;      
COMPND  34 CHAIN: S;                                                            
COMPND  35 SYNONYM: EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT GAMMA X, 
COMPND  36 EIF-2GX;                                                             
COMPND  37 ENGINEERED: YES;                                                     
COMPND  38 MOL_ID: 8;                                                           
COMPND  39 MOLECULE: EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT BETA;   
COMPND  40 CHAIN: d;                                                            
COMPND  41 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   3 ORGANISM_COMMON: HUMAN;                                              
SOURCE   4 ORGANISM_TAXID: 9606;                                                
SOURCE   5 GENE: EIF2B5, EIF2BE;                                                
SOURCE   6 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE   8 MOL_ID: 2;                                                           
SOURCE   9 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  10 ORGANISM_COMMON: HUMAN;                                              
SOURCE  11 ORGANISM_TAXID: 9606;                                                
SOURCE  12 GENE: EIF2B2, EIF2BB;                                                
SOURCE  13 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  14 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE  15 MOL_ID: 3;                                                           
SOURCE  16 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  17 ORGANISM_COMMON: HUMAN;                                              
SOURCE  18 ORGANISM_TAXID: 9606;                                                
SOURCE  19 GENE: EIF2B4, EIF2BD;                                                
SOURCE  20 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  21 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE  22 MOL_ID: 4;                                                           
SOURCE  23 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  24 ORGANISM_COMMON: HUMAN;                                              
SOURCE  25 ORGANISM_TAXID: 9606;                                                
SOURCE  26 GENE: EIF2B1, EIF2BA;                                                
SOURCE  27 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  28 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE  29 MOL_ID: 5;                                                           
SOURCE  30 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  31 ORGANISM_COMMON: HUMAN;                                              
SOURCE  32 ORGANISM_TAXID: 9606;                                                
SOURCE  33 GENE: EIF2B3;                                                        
SOURCE  34 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  35 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE  36 MOL_ID: 6;                                                           
SOURCE  37 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  38 ORGANISM_COMMON: HUMAN;                                              
SOURCE  39 ORGANISM_TAXID: 9606;                                                
SOURCE  40 GENE: EIF2S1, EIF2A;                                                 
SOURCE  41 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  42 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE  43 MOL_ID: 7;                                                           
SOURCE  44 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  45 ORGANISM_COMMON: HUMAN;                                              
SOURCE  46 ORGANISM_TAXID: 9606;                                                
SOURCE  47 GENE: EIF2S3, EIF2G;                                                 
SOURCE  48 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  49 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE  50 MOL_ID: 8;                                                           
SOURCE  51 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  52 ORGANISM_COMMON: HUMAN;                                              
SOURCE  53 ORGANISM_TAXID: 9606;                                                
SOURCE  54 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  55 EXPRESSION_SYSTEM_TAXID: 562                                         
KEYWDS    EUKARYOTIC TRANSLATION INITIATION FACTOR 2B, EUKARYOTIC TRANSLATION   
KEYWDS   2 INITIATION FACTOR 2, TRANSLATION                                     
EXPDTA    ELECTRON MICROSCOPY                                                   
AUTHOR    H.C.NGUYEN,L.R.KENNER,A.S.FROST                                       
REVDAT   3   18-DEC-19 6O85    1       CRYST1 SCALE                             
REVDAT   2   20-NOV-19 6O85    1       HETSYN                                   
REVDAT   1   15-MAY-19 6O85    0                                                
JRNL        AUTH   L.R.KENNER,A.A.ANAND,H.C.NGUYEN,A.G.MYASNIKOV,C.J.KLOSE,     
JRNL        AUTH 2 L.A.MCGEEVER,J.C.TSAI,L.E.MILLER-VEDAM,P.WALTER,A.FROST      
JRNL        TITL   EIF2B-CATALYZED NUCLEOTIDE EXCHANGE AND PHOSPHOREGULATION BY 
JRNL        TITL 2 THE INTEGRATED STRESS RESPONSE.                              
JRNL        REF    SCIENCE                       V. 364   491 2019              
JRNL        REFN                   ESSN 1095-9203                               
JRNL        PMID   31048491                                                     
JRNL        DOI    10.1126/SCIENCE.AAW2922                                      
REMARK   2                                                                      
REMARK   2 RESOLUTION.    3.03 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   SOFTWARE PACKAGES      : NULL                                      
REMARK   3   RECONSTRUCTION SCHEMA  : NULL                                      
REMARK   3                                                                      
REMARK   3 EM MAP-MODEL FITTING AND REFINEMENT                                  
REMARK   3   PDB ENTRY                    : NULL                                
REMARK   3   REFINEMENT SPACE             : NULL                                
REMARK   3   REFINEMENT PROTOCOL          : NULL                                
REMARK   3   REFINEMENT TARGET            : NULL                                
REMARK   3   OVERALL ANISOTROPIC B VALUE  : NULL                                
REMARK   3                                                                      
REMARK   3 FITTING PROCEDURE : NULL                                             
REMARK   3                                                                      
REMARK   3 EM IMAGE RECONSTRUCTION STATISTICS                                   
REMARK   3   NOMINAL PIXEL SIZE (ANGSTROMS)    : NULL                           
REMARK   3   ACTUAL PIXEL SIZE  (ANGSTROMS)    : NULL                           
REMARK   3   EFFECTIVE RESOLUTION (ANGSTROMS)  : 3.030                          
REMARK   3   NUMBER OF PARTICLES               : 44157                          
REMARK   3   CTF CORRECTION METHOD             : PHASE FLIPPING AND AMPLITUDE   
REMARK   3                                       CORRECTION                     
REMARK   3                                                                      
REMARK   3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL                    
REMARK   3                                                                      
REMARK   3 OTHER DETAILS: NULL                                                  
REMARK   4                                                                      
REMARK   4 6O85 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 11-MAR-19.                  
REMARK 100 THE DEPOSITION ID IS D_1000238719.                                   
REMARK 245                                                                      
REMARK 245 EXPERIMENTAL DETAILS                                                 
REMARK 245   RECONSTRUCTION METHOD          : SINGLE PARTICLE                   
REMARK 245   SPECIMEN TYPE                  : NULL                              
REMARK 245                                                                      
REMARK 245 ELECTRON MICROSCOPE SAMPLE                                           
REMARK 245   SAMPLE TYPE                    : PARTICLE                          
REMARK 245   PARTICLE TYPE                  : POINT                             
REMARK 245   NAME OF SAMPLE                 : EIF2 BOUND TO EIF2B               
REMARK 245   SAMPLE CONCENTRATION (MG ML-1) : NULL                              
REMARK 245   SAMPLE SUPPORT DETAILS         : UNSPECIFIED                       
REMARK 245   SAMPLE VITRIFICATION DETAILS   : NULL                              
REMARK 245   SAMPLE BUFFER                  : NULL                              
REMARK 245   PH                             : 7.50                              
REMARK 245   SAMPLE DETAILS                 : NULL                              
REMARK 245                                                                      
REMARK 245 DATA ACQUISITION                                                     
REMARK 245   DATE OF EXPERIMENT                : NULL                           
REMARK 245   NUMBER OF MICROGRAPHS-IMAGES      : NULL                           
REMARK 245   TEMPERATURE (KELVIN)              : NULL                           
REMARK 245   MICROSCOPE MODEL                  : FEI TITAN KRIOS                
REMARK 245   DETECTOR TYPE                     : GATAN K2 SUMMIT (4K X 4K)      
REMARK 245   MINIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MAXIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MINIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   MAXIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   NOMINAL CS                        : NULL                           
REMARK 245   IMAGING MODE                      : BRIGHT FIELD                   
REMARK 245   ELECTRON DOSE (ELECTRONS NM**-2)  : 80.00                          
REMARK 245   ILLUMINATION MODE                 : FLOOD BEAM                     
REMARK 245   NOMINAL MAGNIFICATION             : NULL                           
REMARK 245   CALIBRATED MAGNIFICATION          : NULL                           
REMARK 245   SOURCE                            : FIELD EMISSION GUN             
REMARK 245   ACCELERATION VOLTAGE (KV)         : 300                            
REMARK 245   IMAGING DETAILS                   : NULL                           
REMARK 247                                                                      
REMARK 247 ELECTRON MICROSCOPY                                                  
REMARK 247  THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON          
REMARK 247  MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE              
REMARK 247  THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES           
REMARK 247  ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION         
REMARK 247  OF THE STRUCTURE FACTORS.                                           
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TRIDECAMERIC                      
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E, F, G, H, I, J,         
REMARK 350                    AND CHAINS: L, S, d                               
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     MET A     1                                                      
REMARK 465     ALA A     2                                                      
REMARK 465     ALA A     3                                                      
REMARK 465     PRO A     4                                                      
REMARK 465     VAL A     5                                                      
REMARK 465     VAL A     6                                                      
REMARK 465     ALA A     7                                                      
REMARK 465     PRO A     8                                                      
REMARK 465     PRO A     9                                                      
REMARK 465     GLY A    10                                                      
REMARK 465     VAL A    11                                                      
REMARK 465     VAL A    12                                                      
REMARK 465     VAL A    13                                                      
REMARK 465     SER A    14                                                      
REMARK 465     ARG A    15                                                      
REMARK 465     ALA A    16                                                      
REMARK 465     ASN A    17                                                      
REMARK 465     LYS A    18                                                      
REMARK 465     ARG A    19                                                      
REMARK 465     SER A    20                                                      
REMARK 465     GLY A    21                                                      
REMARK 465     ALA A    22                                                      
REMARK 465     GLY A    23                                                      
REMARK 465     PRO A    24                                                      
REMARK 465     GLY A    25                                                      
REMARK 465     GLY A    26                                                      
REMARK 465     SER A    27                                                      
REMARK 465     GLY A    28                                                      
REMARK 465     GLY A    29                                                      
REMARK 465     GLY A    30                                                      
REMARK 465     GLY A    31                                                      
REMARK 465     ALA A    32                                                      
REMARK 465     ARG A    33                                                      
REMARK 465     GLY A    34                                                      
REMARK 465     ALA A    35                                                      
REMARK 465     GLU A    36                                                      
REMARK 465     GLU A    37                                                      
REMARK 465     GLU A    38                                                      
REMARK 465     PRO A    39                                                      
REMARK 465     PRO A    40                                                      
REMARK 465     ASP A   467                                                      
REMARK 465     ASP A   468                                                      
REMARK 465     SER A   469                                                      
REMARK 465     GLY A   470                                                      
REMARK 465     ALA A   471                                                      
REMARK 465     ASP A   472                                                      
REMARK 465     GLN A   473                                                      
REMARK 465     GLU A   474                                                      
REMARK 465     LYS A   475                                                      
REMARK 465     ASP A   476                                                      
REMARK 465     LYS A   477                                                      
REMARK 465     VAL A   478                                                      
REMARK 465     LYS A   479                                                      
REMARK 465     MET A   480                                                      
REMARK 465     LYS A   481                                                      
REMARK 465     GLY A   482                                                      
REMARK 465     TYR A   483                                                      
REMARK 465     ASN A   484                                                      
REMARK 465     PRO A   485                                                      
REMARK 465     ALA A   486                                                      
REMARK 465     GLU A   487                                                      
REMARK 465     VAL A   488                                                      
REMARK 465     GLY A   489                                                      
REMARK 465     ALA A   490                                                      
REMARK 465     ALA A   491                                                      
REMARK 465     GLY A   492                                                      
REMARK 465     LYS A   493                                                      
REMARK 465     GLY A   494                                                      
REMARK 465     TYR A   495                                                      
REMARK 465     LEU A   496                                                      
REMARK 465     TRP A   497                                                      
REMARK 465     LYS A   498                                                      
REMARK 465     ALA A   499                                                      
REMARK 465     ALA A   500                                                      
REMARK 465     GLY A   501                                                      
REMARK 465     MET A   502                                                      
REMARK 465     ASN A   503                                                      
REMARK 465     MET A   504                                                      
REMARK 465     GLU A   505                                                      
REMARK 465     GLU A   506                                                      
REMARK 465     GLU A   507                                                      
REMARK 465     GLU A   508                                                      
REMARK 465     GLU A   509                                                      
REMARK 465     LEU A   510                                                      
REMARK 465     GLN A   511                                                      
REMARK 465     GLN A   512                                                      
REMARK 465     ASN A   513                                                      
REMARK 465     LEU A   514                                                      
REMARK 465     TRP A   515                                                      
REMARK 465     GLY A   516                                                      
REMARK 465     LEU A   517                                                      
REMARK 465     LYS A   518                                                      
REMARK 465     ILE A   519                                                      
REMARK 465     ASN A   520                                                      
REMARK 465     MET A   521                                                      
REMARK 465     GLU A   522                                                      
REMARK 465     GLU A   523                                                      
REMARK 465     GLU A   524                                                      
REMARK 465     SER A   525                                                      
REMARK 465     GLU A   526                                                      
REMARK 465     SER A   527                                                      
REMARK 465     GLU A   528                                                      
REMARK 465     SER A   529                                                      
REMARK 465     GLU A   530                                                      
REMARK 465     GLN A   531                                                      
REMARK 465     SER A   532                                                      
REMARK 465     MET A   533                                                      
REMARK 465     ASP A   534                                                      
REMARK 465     SER A   535                                                      
REMARK 465     GLU A   536                                                      
REMARK 465     GLU A   537                                                      
REMARK 465     PRO A   538                                                      
REMARK 465     ASP A   539                                                      
REMARK 465     SER A   540                                                      
REMARK 465     ARG A   541                                                      
REMARK 465     GLY A   542                                                      
REMARK 465     GLY A   543                                                      
REMARK 465     SER A   544                                                      
REMARK 465     PRO A   545                                                      
REMARK 465     GLN A   546                                                      
REMARK 465     MET A   547                                                      
REMARK 465     ASP A   548                                                      
REMARK 465     ASP A   549                                                      
REMARK 465     ILE A   550                                                      
REMARK 465     LYS A   551                                                      
REMARK 465     VAL A   552                                                      
REMARK 465     PHE A   553                                                      
REMARK 465     GLN A   554                                                      
REMARK 465     ASN A   555                                                      
REMARK 465     GLU A   556                                                      
REMARK 465     VAL A   557                                                      
REMARK 465     LEU A   558                                                      
REMARK 465     GLY A   559                                                      
REMARK 465     THR A   560                                                      
REMARK 465     LEU A   561                                                      
REMARK 465     GLN A   562                                                      
REMARK 465     ARG A   563                                                      
REMARK 465     GLY A   564                                                      
REMARK 465     LYS A   565                                                      
REMARK 465     GLU A   566                                                      
REMARK 465     GLU A   567                                                      
REMARK 465     ASN A   568                                                      
REMARK 465     ILE A   569                                                      
REMARK 465     SER A   570                                                      
REMARK 465     CYS A   571                                                      
REMARK 465     ASP A   572                                                      
REMARK 465     ASN A   573                                                      
REMARK 465     LEU A   574                                                      
REMARK 465     VAL A   575                                                      
REMARK 465     LEU A   576                                                      
REMARK 465     GLU A   577                                                      
REMARK 465     ILE A   578                                                      
REMARK 465     ASN A   579                                                      
REMARK 465     SER A   580                                                      
REMARK 465     LEU A   581                                                      
REMARK 465     LYS A   582                                                      
REMARK 465     TYR A   583                                                      
REMARK 465     ALA A   584                                                      
REMARK 465     TYR A   585                                                      
REMARK 465     ASN A   586                                                      
REMARK 465     ILE A   587                                                      
REMARK 465     SER A   588                                                      
REMARK 465     LEU A   589                                                      
REMARK 465     LYS A   590                                                      
REMARK 465     GLU A   591                                                      
REMARK 465     VAL A   592                                                      
REMARK 465     MET A   593                                                      
REMARK 465     GLN A   594                                                      
REMARK 465     VAL A   595                                                      
REMARK 465     LEU A   596                                                      
REMARK 465     SER A   597                                                      
REMARK 465     HIS A   598                                                      
REMARK 465     VAL A   599                                                      
REMARK 465     VAL A   600                                                      
REMARK 465     LEU A   601                                                      
REMARK 465     GLU A   602                                                      
REMARK 465     PHE A   603                                                      
REMARK 465     PRO A   604                                                      
REMARK 465     LEU A   605                                                      
REMARK 465     GLN A   606                                                      
REMARK 465     GLN A   607                                                      
REMARK 465     MET A   608                                                      
REMARK 465     ASP A   609                                                      
REMARK 465     SER A   610                                                      
REMARK 465     PRO A   611                                                      
REMARK 465     LEU A   612                                                      
REMARK 465     ASP A   613                                                      
REMARK 465     SER A   614                                                      
REMARK 465     SER A   615                                                      
REMARK 465     ARG A   616                                                      
REMARK 465     TYR A   617                                                      
REMARK 465     CYS A   618                                                      
REMARK 465     ALA A   619                                                      
REMARK 465     LEU A   620                                                      
REMARK 465     LEU A   621                                                      
REMARK 465     LEU A   622                                                      
REMARK 465     PRO A   623                                                      
REMARK 465     LEU A   624                                                      
REMARK 465     LEU A   625                                                      
REMARK 465     LYS A   626                                                      
REMARK 465     ALA A   627                                                      
REMARK 465     TRP A   628                                                      
REMARK 465     SER A   629                                                      
REMARK 465     PRO A   630                                                      
REMARK 465     VAL A   631                                                      
REMARK 465     PHE A   632                                                      
REMARK 465     ARG A   633                                                      
REMARK 465     ASN A   634                                                      
REMARK 465     TYR A   635                                                      
REMARK 465     ILE A   636                                                      
REMARK 465     LYS A   637                                                      
REMARK 465     ARG A   638                                                      
REMARK 465     ALA A   639                                                      
REMARK 465     ALA A   640                                                      
REMARK 465     ASP A   641                                                      
REMARK 465     HIS A   642                                                      
REMARK 465     LEU A   643                                                      
REMARK 465     GLU A   644                                                      
REMARK 465     ALA A   645                                                      
REMARK 465     LEU A   646                                                      
REMARK 465     ALA A   647                                                      
REMARK 465     ALA A   648                                                      
REMARK 465     ILE A   649                                                      
REMARK 465     GLU A   650                                                      
REMARK 465     ASP A   651                                                      
REMARK 465     PHE A   652                                                      
REMARK 465     PHE A   653                                                      
REMARK 465     LEU A   654                                                      
REMARK 465     GLU A   655                                                      
REMARK 465     HIS A   656                                                      
REMARK 465     GLU A   657                                                      
REMARK 465     ALA A   658                                                      
REMARK 465     LEU A   659                                                      
REMARK 465     GLY A   660                                                      
REMARK 465     ILE A   661                                                      
REMARK 465     SER A   662                                                      
REMARK 465     MET A   663                                                      
REMARK 465     ALA A   664                                                      
REMARK 465     LYS A   665                                                      
REMARK 465     VAL A   666                                                      
REMARK 465     LEU A   667                                                      
REMARK 465     MET A   668                                                      
REMARK 465     ALA A   669                                                      
REMARK 465     PHE A   670                                                      
REMARK 465     TYR A   671                                                      
REMARK 465     GLN A   672                                                      
REMARK 465     LEU A   673                                                      
REMARK 465     GLU A   674                                                      
REMARK 465     ILE A   675                                                      
REMARK 465     LEU A   676                                                      
REMARK 465     ALA A   677                                                      
REMARK 465     GLU A   678                                                      
REMARK 465     GLU A   679                                                      
REMARK 465     THR A   680                                                      
REMARK 465     ILE A   681                                                      
REMARK 465     LEU A   682                                                      
REMARK 465     SER A   683                                                      
REMARK 465     TRP A   684                                                      
REMARK 465     PHE A   685                                                      
REMARK 465     SER A   686                                                      
REMARK 465     GLN A   687                                                      
REMARK 465     ARG A   688                                                      
REMARK 465     ASP A   689                                                      
REMARK 465     THR A   690                                                      
REMARK 465     THR A   691                                                      
REMARK 465     ASP A   692                                                      
REMARK 465     LYS A   693                                                      
REMARK 465     GLY A   694                                                      
REMARK 465     GLN A   695                                                      
REMARK 465     GLN A   696                                                      
REMARK 465     LEU A   697                                                      
REMARK 465     ARG A   698                                                      
REMARK 465     LYS A   699                                                      
REMARK 465     ASN A   700                                                      
REMARK 465     GLN A   701                                                      
REMARK 465     GLN A   702                                                      
REMARK 465     LEU A   703                                                      
REMARK 465     GLN A   704                                                      
REMARK 465     ARG A   705                                                      
REMARK 465     PHE A   706                                                      
REMARK 465     ILE A   707                                                      
REMARK 465     GLN A   708                                                      
REMARK 465     TRP A   709                                                      
REMARK 465     LEU A   710                                                      
REMARK 465     LYS A   711                                                      
REMARK 465     GLU A   712                                                      
REMARK 465     ALA A   713                                                      
REMARK 465     GLU A   714                                                      
REMARK 465     GLU A   715                                                      
REMARK 465     GLU A   716                                                      
REMARK 465     SER A   717                                                      
REMARK 465     SER A   718                                                      
REMARK 465     GLU A   719                                                      
REMARK 465     ASP A   720                                                      
REMARK 465     ASP A   721                                                      
REMARK 465     MET B     1                                                      
REMARK 465     ALA B     2                                                      
REMARK 465     ALA B     3                                                      
REMARK 465     PRO B     4                                                      
REMARK 465     VAL B     5                                                      
REMARK 465     VAL B     6                                                      
REMARK 465     ALA B     7                                                      
REMARK 465     PRO B     8                                                      
REMARK 465     PRO B     9                                                      
REMARK 465     GLY B    10                                                      
REMARK 465     VAL B    11                                                      
REMARK 465     VAL B    12                                                      
REMARK 465     VAL B    13                                                      
REMARK 465     SER B    14                                                      
REMARK 465     ARG B    15                                                      
REMARK 465     ALA B    16                                                      
REMARK 465     ASN B    17                                                      
REMARK 465     LYS B    18                                                      
REMARK 465     ARG B    19                                                      
REMARK 465     SER B    20                                                      
REMARK 465     GLY B    21                                                      
REMARK 465     ALA B    22                                                      
REMARK 465     GLY B    23                                                      
REMARK 465     PRO B    24                                                      
REMARK 465     GLY B    25                                                      
REMARK 465     GLY B    26                                                      
REMARK 465     SER B    27                                                      
REMARK 465     GLY B    28                                                      
REMARK 465     GLY B    29                                                      
REMARK 465     GLY B    30                                                      
REMARK 465     GLY B    31                                                      
REMARK 465     ALA B    32                                                      
REMARK 465     ARG B    33                                                      
REMARK 465     GLY B    34                                                      
REMARK 465     ALA B    35                                                      
REMARK 465     GLU B    36                                                      
REMARK 465     GLU B    37                                                      
REMARK 465     GLU B    38                                                      
REMARK 465     PRO B    39                                                      
REMARK 465     PRO B    40                                                      
REMARK 465     ASP B   467                                                      
REMARK 465     ASP B   468                                                      
REMARK 465     SER B   469                                                      
REMARK 465     GLY B   470                                                      
REMARK 465     ALA B   471                                                      
REMARK 465     ASP B   472                                                      
REMARK 465     GLN B   473                                                      
REMARK 465     GLU B   474                                                      
REMARK 465     LYS B   475                                                      
REMARK 465     ASP B   476                                                      
REMARK 465     LYS B   477                                                      
REMARK 465     VAL B   478                                                      
REMARK 465     LYS B   479                                                      
REMARK 465     MET B   480                                                      
REMARK 465     LYS B   481                                                      
REMARK 465     GLY B   482                                                      
REMARK 465     TYR B   483                                                      
REMARK 465     ASN B   484                                                      
REMARK 465     PRO B   485                                                      
REMARK 465     ALA B   486                                                      
REMARK 465     GLU B   487                                                      
REMARK 465     VAL B   488                                                      
REMARK 465     GLY B   489                                                      
REMARK 465     ALA B   490                                                      
REMARK 465     ALA B   491                                                      
REMARK 465     GLY B   492                                                      
REMARK 465     LYS B   493                                                      
REMARK 465     GLY B   494                                                      
REMARK 465     TYR B   495                                                      
REMARK 465     LEU B   496                                                      
REMARK 465     TRP B   497                                                      
REMARK 465     LYS B   498                                                      
REMARK 465     ALA B   499                                                      
REMARK 465     ALA B   500                                                      
REMARK 465     GLY B   501                                                      
REMARK 465     MET B   502                                                      
REMARK 465     ASN B   503                                                      
REMARK 465     MET B   504                                                      
REMARK 465     GLU B   505                                                      
REMARK 465     GLU B   506                                                      
REMARK 465     GLU B   507                                                      
REMARK 465     GLU B   508                                                      
REMARK 465     GLU B   509                                                      
REMARK 465     LEU B   510                                                      
REMARK 465     GLN B   511                                                      
REMARK 465     GLN B   512                                                      
REMARK 465     ASN B   513                                                      
REMARK 465     LEU B   514                                                      
REMARK 465     TRP B   515                                                      
REMARK 465     GLY B   516                                                      
REMARK 465     LEU B   517                                                      
REMARK 465     LYS B   518                                                      
REMARK 465     ILE B   519                                                      
REMARK 465     ASN B   520                                                      
REMARK 465     MET B   521                                                      
REMARK 465     GLU B   522                                                      
REMARK 465     GLU B   523                                                      
REMARK 465     GLU B   524                                                      
REMARK 465     SER B   525                                                      
REMARK 465     GLU B   526                                                      
REMARK 465     SER B   527                                                      
REMARK 465     GLU B   528                                                      
REMARK 465     SER B   529                                                      
REMARK 465     GLU B   530                                                      
REMARK 465     GLN B   531                                                      
REMARK 465     SER B   532                                                      
REMARK 465     MET B   533                                                      
REMARK 465     ASP B   534                                                      
REMARK 465     SER B   535                                                      
REMARK 465     GLU B   536                                                      
REMARK 465     GLU B   537                                                      
REMARK 465     PRO B   538                                                      
REMARK 465     ASP B   539                                                      
REMARK 465     SER B   540                                                      
REMARK 465     ARG B   541                                                      
REMARK 465     GLY B   542                                                      
REMARK 465     GLY B   543                                                      
REMARK 465     SER B   544                                                      
REMARK 465     PRO B   545                                                      
REMARK 465     GLN B   546                                                      
REMARK 465     MET B   547                                                      
REMARK 465     ASP B   548                                                      
REMARK 465     ASP B   689                                                      
REMARK 465     THR B   690                                                      
REMARK 465     THR B   691                                                      
REMARK 465     GLU B   716                                                      
REMARK 465     SER B   717                                                      
REMARK 465     SER B   718                                                      
REMARK 465     GLU B   719                                                      
REMARK 465     ASP B   720                                                      
REMARK 465     ASP B   721                                                      
REMARK 465     MET C   -16                                                      
REMARK 465     HIS C   -15                                                      
REMARK 465     HIS C   -14                                                      
REMARK 465     HIS C   -13                                                      
REMARK 465     HIS C   -12                                                      
REMARK 465     HIS C   -11                                                      
REMARK 465     HIS C   -10                                                      
REMARK 465     GLY C    -9                                                      
REMARK 465     GLY C    -8                                                      
REMARK 465     GLY C    -7                                                      
REMARK 465     SER C    -6                                                      
REMARK 465     GLU C    -5                                                      
REMARK 465     ASN C    -4                                                      
REMARK 465     LEU C    -3                                                      
REMARK 465     TYR C    -2                                                      
REMARK 465     PHE C    -1                                                      
REMARK 465     GLN C     0                                                      
REMARK 465     SER C     1                                                      
REMARK 465     PRO C     2                                                      
REMARK 465     GLY C     3                                                      
REMARK 465     SER C     4                                                      
REMARK 465     ALA C     5                                                      
REMARK 465     ALA C     6                                                      
REMARK 465     LYS C     7                                                      
REMARK 465     ARG C    99                                                      
REMARK 465     SER C   100                                                      
REMARK 465     ASP C   101                                                      
REMARK 465     GLU C   102                                                      
REMARK 465     SER C   103                                                      
REMARK 465     ASP C   104                                                      
REMARK 465     GLN C   105                                                      
REMARK 465     GLN C   106                                                      
REMARK 465     GLU C   107                                                      
REMARK 465     SER C   108                                                      
REMARK 465     LEU C   109                                                      
REMARK 465     HIS C   110                                                      
REMARK 465     LYS C   111                                                      
REMARK 465     LEU C   112                                                      
REMARK 465     LEU C   113                                                      
REMARK 465     THR C   114                                                      
REMARK 465     SER C   115                                                      
REMARK 465     GLY C   116                                                      
REMARK 465     GLY C   117                                                      
REMARK 465     LEU C   118                                                      
REMARK 465     ASN C   119                                                      
REMARK 465     GLU C   120                                                      
REMARK 465     ASP C   121                                                      
REMARK 465     PHE C   122                                                      
REMARK 465     SER C   123                                                      
REMARK 465     PHE C   124                                                      
REMARK 465     HIS C   125                                                      
REMARK 465     MET D   -16                                                      
REMARK 465     HIS D   -15                                                      
REMARK 465     HIS D   -14                                                      
REMARK 465     HIS D   -13                                                      
REMARK 465     HIS D   -12                                                      
REMARK 465     HIS D   -11                                                      
REMARK 465     HIS D   -10                                                      
REMARK 465     GLY D    -9                                                      
REMARK 465     GLY D    -8                                                      
REMARK 465     GLY D    -7                                                      
REMARK 465     SER D    -6                                                      
REMARK 465     GLU D    -5                                                      
REMARK 465     ASN D    -4                                                      
REMARK 465     LEU D    -3                                                      
REMARK 465     TYR D    -2                                                      
REMARK 465     PHE D    -1                                                      
REMARK 465     GLN D     0                                                      
REMARK 465     SER D     1                                                      
REMARK 465     PRO D     2                                                      
REMARK 465     GLY D     3                                                      
REMARK 465     SER D     4                                                      
REMARK 465     ALA D     5                                                      
REMARK 465     ALA D     6                                                      
REMARK 465     LYS D     7                                                      
REMARK 465     ARG D    99                                                      
REMARK 465     SER D   100                                                      
REMARK 465     ASP D   101                                                      
REMARK 465     GLU D   102                                                      
REMARK 465     SER D   103                                                      
REMARK 465     ASP D   104                                                      
REMARK 465     GLN D   105                                                      
REMARK 465     GLN D   106                                                      
REMARK 465     GLU D   107                                                      
REMARK 465     SER D   108                                                      
REMARK 465     LEU D   109                                                      
REMARK 465     HIS D   110                                                      
REMARK 465     LYS D   111                                                      
REMARK 465     LEU D   112                                                      
REMARK 465     LEU D   113                                                      
REMARK 465     THR D   114                                                      
REMARK 465     SER D   115                                                      
REMARK 465     GLY D   116                                                      
REMARK 465     GLY D   117                                                      
REMARK 465     LEU D   118                                                      
REMARK 465     ASN D   119                                                      
REMARK 465     GLU D   120                                                      
REMARK 465     ASP D   121                                                      
REMARK 465     PHE D   122                                                      
REMARK 465     SER D   123                                                      
REMARK 465     PHE D   124                                                      
REMARK 465     MET E     1                                                      
REMARK 465     ALA E     2                                                      
REMARK 465     ALA E     3                                                      
REMARK 465     VAL E     4                                                      
REMARK 465     ALA E     5                                                      
REMARK 465     VAL E     6                                                      
REMARK 465     ALA E     7                                                      
REMARK 465     VAL E     8                                                      
REMARK 465     ARG E     9                                                      
REMARK 465     GLU E    10                                                      
REMARK 465     ASP E    11                                                      
REMARK 465     SER E    12                                                      
REMARK 465     GLY E    13                                                      
REMARK 465     SER E    14                                                      
REMARK 465     GLY E    15                                                      
REMARK 465     MET E    16                                                      
REMARK 465     LYS E    17                                                      
REMARK 465     ALA E    18                                                      
REMARK 465     GLU E    19                                                      
REMARK 465     LEU E    20                                                      
REMARK 465     PRO E    21                                                      
REMARK 465     PRO E    22                                                      
REMARK 465     GLY E    23                                                      
REMARK 465     PRO E    24                                                      
REMARK 465     GLY E    25                                                      
REMARK 465     ALA E    26                                                      
REMARK 465     VAL E    27                                                      
REMARK 465     GLY E    28                                                      
REMARK 465     ARG E    29                                                      
REMARK 465     GLU E    30                                                      
REMARK 465     MET E    31                                                      
REMARK 465     THR E    32                                                      
REMARK 465     LYS E    33                                                      
REMARK 465     GLU E    34                                                      
REMARK 465     GLU E    35                                                      
REMARK 465     LYS E    36                                                      
REMARK 465     LEU E    37                                                      
REMARK 465     GLN E    38                                                      
REMARK 465     LEU E    39                                                      
REMARK 465     ARG E    40                                                      
REMARK 465     LYS E    41                                                      
REMARK 465     GLU E    42                                                      
REMARK 465     LYS E    43                                                      
REMARK 465     LYS E    44                                                      
REMARK 465     GLN E    45                                                      
REMARK 465     GLN E    46                                                      
REMARK 465     LYS E    47                                                      
REMARK 465     LYS E    48                                                      
REMARK 465     LYS E    49                                                      
REMARK 465     ARG E    50                                                      
REMARK 465     LYS E    51                                                      
REMARK 465     GLU E    52                                                      
REMARK 465     GLU E    53                                                      
REMARK 465     LYS E    54                                                      
REMARK 465     GLY E    55                                                      
REMARK 465     ALA E    56                                                      
REMARK 465     GLU E    57                                                      
REMARK 465     PRO E    58                                                      
REMARK 465     GLU E    59                                                      
REMARK 465     THR E    60                                                      
REMARK 465     GLY E    61                                                      
REMARK 465     SER E    62                                                      
REMARK 465     ALA E    63                                                      
REMARK 465     VAL E    64                                                      
REMARK 465     SER E    65                                                      
REMARK 465     ALA E    66                                                      
REMARK 465     ALA E    67                                                      
REMARK 465     GLN E    68                                                      
REMARK 465     CYS E    69                                                      
REMARK 465     GLN E    70                                                      
REMARK 465     VAL E    71                                                      
REMARK 465     GLY E    72                                                      
REMARK 465     PRO E    73                                                      
REMARK 465     THR E    74                                                      
REMARK 465     ARG E    75                                                      
REMARK 465     GLU E    76                                                      
REMARK 465     LEU E    77                                                      
REMARK 465     PRO E    78                                                      
REMARK 465     GLU E    79                                                      
REMARK 465     SER E    80                                                      
REMARK 465     GLY E    81                                                      
REMARK 465     ILE E    82                                                      
REMARK 465     GLN E    83                                                      
REMARK 465     LEU E    84                                                      
REMARK 465     GLY E    85                                                      
REMARK 465     THR E    86                                                      
REMARK 465     PRO E    87                                                      
REMARK 465     ARG E    88                                                      
REMARK 465     GLU E    89                                                      
REMARK 465     LYS E    90                                                      
REMARK 465     VAL E    91                                                      
REMARK 465     PRO E    92                                                      
REMARK 465     ALA E    93                                                      
REMARK 465     GLY E    94                                                      
REMARK 465     ARG E    95                                                      
REMARK 465     SER E    96                                                      
REMARK 465     LYS E    97                                                      
REMARK 465     ALA E    98                                                      
REMARK 465     GLU E    99                                                      
REMARK 465     LEU E   100                                                      
REMARK 465     ARG E   101                                                      
REMARK 465     ALA E   102                                                      
REMARK 465     GLU E   103                                                      
REMARK 465     ARG E   104                                                      
REMARK 465     ARG E   105                                                      
REMARK 465     ALA E   106                                                      
REMARK 465     LYS E   107                                                      
REMARK 465     GLN E   108                                                      
REMARK 465     GLU E   109                                                      
REMARK 465     ALA E   110                                                      
REMARK 465     GLU E   111                                                      
REMARK 465     ARG E   112                                                      
REMARK 465     ALA E   113                                                      
REMARK 465     LEU E   114                                                      
REMARK 465     LYS E   115                                                      
REMARK 465     GLN E   116                                                      
REMARK 465     ALA E   117                                                      
REMARK 465     ARG E   118                                                      
REMARK 465     LYS E   119                                                      
REMARK 465     GLY E   120                                                      
REMARK 465     GLU E   121                                                      
REMARK 465     GLN E   122                                                      
REMARK 465     GLY E   123                                                      
REMARK 465     GLY E   124                                                      
REMARK 465     PRO E   125                                                      
REMARK 465     PRO E   126                                                      
REMARK 465     PRO E   127                                                      
REMARK 465     LYS E   128                                                      
REMARK 465     ALA E   129                                                      
REMARK 465     SER E   130                                                      
REMARK 465     PRO E   131                                                      
REMARK 465     SER E   132                                                      
REMARK 465     THR E   133                                                      
REMARK 465     ALA E   134                                                      
REMARK 465     GLY E   135                                                      
REMARK 465     GLU E   136                                                      
REMARK 465     THR E   137                                                      
REMARK 465     PRO E   138                                                      
REMARK 465     SER E   139                                                      
REMARK 465     GLY E   140                                                      
REMARK 465     VAL E   141                                                      
REMARK 465     LYS E   142                                                      
REMARK 465     ARG E   143                                                      
REMARK 465     LEU E   144                                                      
REMARK 465     PRO E   145                                                      
REMARK 465     GLU E   146                                                      
REMARK 465     TYR E   147                                                      
REMARK 465     PRO E   148                                                      
REMARK 465     GLN E   149                                                      
REMARK 465     VAL E   150                                                      
REMARK 465     ASP E   151                                                      
REMARK 465     ASP E   152                                                      
REMARK 465     LEU E   153                                                      
REMARK 465     LEU E   154                                                      
REMARK 465     LEU E   155                                                      
REMARK 465     ARG E   156                                                      
REMARK 465     ARG E   157                                                      
REMARK 465     LEU E   158                                                      
REMARK 465     VAL E   159                                                      
REMARK 465     LYS E   160                                                      
REMARK 465     LYS E   161                                                      
REMARK 465     PRO E   162                                                      
REMARK 465     GLU E   163                                                      
REMARK 465     ARG E   164                                                      
REMARK 465     GLN E   165                                                      
REMARK 465     GLN E   523                                                      
REMARK 465     MET F     1                                                      
REMARK 465     ALA F     2                                                      
REMARK 465     ALA F     3                                                      
REMARK 465     VAL F     4                                                      
REMARK 465     ALA F     5                                                      
REMARK 465     VAL F     6                                                      
REMARK 465     ALA F     7                                                      
REMARK 465     VAL F     8                                                      
REMARK 465     ARG F     9                                                      
REMARK 465     GLU F    10                                                      
REMARK 465     ASP F    11                                                      
REMARK 465     SER F    12                                                      
REMARK 465     GLY F    13                                                      
REMARK 465     SER F    14                                                      
REMARK 465     GLY F    15                                                      
REMARK 465     MET F    16                                                      
REMARK 465     LYS F    17                                                      
REMARK 465     ALA F    18                                                      
REMARK 465     GLU F    19                                                      
REMARK 465     LEU F    20                                                      
REMARK 465     PRO F    21                                                      
REMARK 465     PRO F    22                                                      
REMARK 465     GLY F    23                                                      
REMARK 465     PRO F    24                                                      
REMARK 465     GLY F    25                                                      
REMARK 465     ALA F    26                                                      
REMARK 465     VAL F    27                                                      
REMARK 465     GLY F    28                                                      
REMARK 465     ARG F    29                                                      
REMARK 465     GLU F    30                                                      
REMARK 465     MET F    31                                                      
REMARK 465     THR F    32                                                      
REMARK 465     LYS F    33                                                      
REMARK 465     GLU F    34                                                      
REMARK 465     GLU F    35                                                      
REMARK 465     LYS F    36                                                      
REMARK 465     LEU F    37                                                      
REMARK 465     GLN F    38                                                      
REMARK 465     LEU F    39                                                      
REMARK 465     ARG F    40                                                      
REMARK 465     LYS F    41                                                      
REMARK 465     GLU F    42                                                      
REMARK 465     LYS F    43                                                      
REMARK 465     LYS F    44                                                      
REMARK 465     GLN F    45                                                      
REMARK 465     GLN F    46                                                      
REMARK 465     LYS F    47                                                      
REMARK 465     LYS F    48                                                      
REMARK 465     LYS F    49                                                      
REMARK 465     ARG F    50                                                      
REMARK 465     LYS F    51                                                      
REMARK 465     GLU F    52                                                      
REMARK 465     GLU F    53                                                      
REMARK 465     LYS F    54                                                      
REMARK 465     GLY F    55                                                      
REMARK 465     ALA F    56                                                      
REMARK 465     GLU F    57                                                      
REMARK 465     PRO F    58                                                      
REMARK 465     GLU F    59                                                      
REMARK 465     THR F    60                                                      
REMARK 465     GLY F    61                                                      
REMARK 465     SER F    62                                                      
REMARK 465     ALA F    63                                                      
REMARK 465     VAL F    64                                                      
REMARK 465     SER F    65                                                      
REMARK 465     ALA F    66                                                      
REMARK 465     ALA F    67                                                      
REMARK 465     GLN F    68                                                      
REMARK 465     CYS F    69                                                      
REMARK 465     GLN F    70                                                      
REMARK 465     VAL F    71                                                      
REMARK 465     GLY F    72                                                      
REMARK 465     PRO F    73                                                      
REMARK 465     THR F    74                                                      
REMARK 465     ARG F    75                                                      
REMARK 465     GLU F    76                                                      
REMARK 465     LEU F    77                                                      
REMARK 465     PRO F    78                                                      
REMARK 465     GLU F    79                                                      
REMARK 465     SER F    80                                                      
REMARK 465     GLY F    81                                                      
REMARK 465     ILE F    82                                                      
REMARK 465     GLN F    83                                                      
REMARK 465     LEU F    84                                                      
REMARK 465     GLY F    85                                                      
REMARK 465     THR F    86                                                      
REMARK 465     PRO F    87                                                      
REMARK 465     ARG F    88                                                      
REMARK 465     GLU F    89                                                      
REMARK 465     LYS F    90                                                      
REMARK 465     VAL F    91                                                      
REMARK 465     PRO F    92                                                      
REMARK 465     ALA F    93                                                      
REMARK 465     GLY F    94                                                      
REMARK 465     ARG F    95                                                      
REMARK 465     SER F    96                                                      
REMARK 465     LYS F    97                                                      
REMARK 465     ALA F    98                                                      
REMARK 465     GLU F    99                                                      
REMARK 465     LEU F   100                                                      
REMARK 465     ARG F   101                                                      
REMARK 465     ALA F   102                                                      
REMARK 465     GLU F   103                                                      
REMARK 465     ARG F   104                                                      
REMARK 465     ARG F   105                                                      
REMARK 465     ALA F   106                                                      
REMARK 465     LYS F   107                                                      
REMARK 465     GLN F   108                                                      
REMARK 465     GLU F   109                                                      
REMARK 465     ALA F   110                                                      
REMARK 465     GLU F   111                                                      
REMARK 465     ARG F   112                                                      
REMARK 465     ALA F   113                                                      
REMARK 465     LEU F   114                                                      
REMARK 465     LYS F   115                                                      
REMARK 465     GLN F   116                                                      
REMARK 465     ALA F   117                                                      
REMARK 465     ARG F   118                                                      
REMARK 465     LYS F   119                                                      
REMARK 465     GLY F   120                                                      
REMARK 465     GLU F   121                                                      
REMARK 465     GLN F   122                                                      
REMARK 465     GLY F   123                                                      
REMARK 465     GLY F   124                                                      
REMARK 465     PRO F   125                                                      
REMARK 465     PRO F   126                                                      
REMARK 465     PRO F   127                                                      
REMARK 465     LYS F   128                                                      
REMARK 465     ALA F   129                                                      
REMARK 465     SER F   130                                                      
REMARK 465     PRO F   131                                                      
REMARK 465     SER F   132                                                      
REMARK 465     THR F   133                                                      
REMARK 465     ALA F   134                                                      
REMARK 465     GLY F   135                                                      
REMARK 465     GLU F   136                                                      
REMARK 465     THR F   137                                                      
REMARK 465     PRO F   138                                                      
REMARK 465     SER F   139                                                      
REMARK 465     GLY F   140                                                      
REMARK 465     VAL F   141                                                      
REMARK 465     LYS F   142                                                      
REMARK 465     ARG F   143                                                      
REMARK 465     LEU F   144                                                      
REMARK 465     PRO F   145                                                      
REMARK 465     GLU F   146                                                      
REMARK 465     TYR F   147                                                      
REMARK 465     PRO F   148                                                      
REMARK 465     GLN F   149                                                      
REMARK 465     VAL F   150                                                      
REMARK 465     ASP F   151                                                      
REMARK 465     ASP F   152                                                      
REMARK 465     LEU F   153                                                      
REMARK 465     LEU F   154                                                      
REMARK 465     LEU F   155                                                      
REMARK 465     ARG F   156                                                      
REMARK 465     ARG F   157                                                      
REMARK 465     LEU F   158                                                      
REMARK 465     VAL F   159                                                      
REMARK 465     LYS F   160                                                      
REMARK 465     LYS F   161                                                      
REMARK 465     PRO F   162                                                      
REMARK 465     GLU F   163                                                      
REMARK 465     ARG F   164                                                      
REMARK 465     GLN F   165                                                      
REMARK 465     GLN F   523                                                      
REMARK 465     MET G     1                                                      
REMARK 465     ASP G     2                                                      
REMARK 465     ASP G     3                                                      
REMARK 465     LYS G   253                                                      
REMARK 465     ALA G   254                                                      
REMARK 465     ASP G   255                                                      
REMARK 465     THR G   256                                                      
REMARK 465     LEU G   257                                                      
REMARK 465     LYS G   258                                                      
REMARK 465     VAL G   259                                                      
REMARK 465     ALA G   260                                                      
REMARK 465     GLN G   261                                                      
REMARK 465     THR G   262                                                      
REMARK 465     GLY G   263                                                      
REMARK 465     GLN G   264                                                      
REMARK 465     ASP G   265                                                      
REMARK 465     LEU G   266                                                      
REMARK 465     LYS G   267                                                      
REMARK 465     GLU G   268                                                      
REMARK 465     GLU G   269                                                      
REMARK 465     MET H     1                                                      
REMARK 465     ASP H     2                                                      
REMARK 465     ASP H     3                                                      
REMARK 465     LYS H   253                                                      
REMARK 465     ALA H   254                                                      
REMARK 465     ASP H   255                                                      
REMARK 465     THR H   256                                                      
REMARK 465     LEU H   257                                                      
REMARK 465     LYS H   258                                                      
REMARK 465     VAL H   259                                                      
REMARK 465     ALA H   260                                                      
REMARK 465     GLN H   261                                                      
REMARK 465     THR H   262                                                      
REMARK 465     GLY H   263                                                      
REMARK 465     GLN H   264                                                      
REMARK 465     ASP H   265                                                      
REMARK 465     LEU H   266                                                      
REMARK 465     LYS H   267                                                      
REMARK 465     GLU H   268                                                      
REMARK 465     GLU H   269                                                      
REMARK 465     GLY I    12                                                      
REMARK 465     GLY I    13                                                      
REMARK 465     SER I    14                                                      
REMARK 465     ARG I    15                                                      
REMARK 465     MET I    16                                                      
REMARK 465     THR I    17                                                      
REMARK 465     ASP I    18                                                      
REMARK 465     LEU I    19                                                      
REMARK 465     THR I    20                                                      
REMARK 465     SER I    21                                                      
REMARK 465     SER I    22                                                      
REMARK 465     ILE I    23                                                      
REMARK 465     PRO I    24                                                      
REMARK 465     LYS I    25                                                      
REMARK 465     PRO I    26                                                      
REMARK 465     LEU I    27                                                      
REMARK 465     GLY I   135                                                      
REMARK 465     GLN I   136                                                      
REMARK 465     ASP I   137                                                      
REMARK 465     SER I   138                                                      
REMARK 465     ILE I   139                                                      
REMARK 465     GLU I   140                                                      
REMARK 465     PRO I   141                                                      
REMARK 465     VAL I   142                                                      
REMARK 465     PRO I   143                                                      
REMARK 465     GLY I   144                                                      
REMARK 465     GLN I   145                                                      
REMARK 465     LYS I   146                                                      
REMARK 465     GLY I   147                                                      
REMARK 465     LYS I   148                                                      
REMARK 465     LYS I   149                                                      
REMARK 465     LYS I   150                                                      
REMARK 465     ALA I   151                                                      
REMARK 465     VAL I   152                                                      
REMARK 465     GLU I   153                                                      
REMARK 465     GLN I   154                                                      
REMARK 465     SER I   239                                                      
REMARK 465     ALA I   240                                                      
REMARK 465     SER I   241                                                      
REMARK 465     SER I   242                                                      
REMARK 465     GLN I   243                                                      
REMARK 465     GLN I   244                                                      
REMARK 465     GLY I   245                                                      
REMARK 465     GLN I   246                                                      
REMARK 465     GLU I   247                                                      
REMARK 465     GLU I   248                                                      
REMARK 465     LYS I   249                                                      
REMARK 465     GLU I   250                                                      
REMARK 465     GLU I   251                                                      
REMARK 465     ASP I   252                                                      
REMARK 465     LEU I   253                                                      
REMARK 465     LYS I   254                                                      
REMARK 465     LYS I   255                                                      
REMARK 465     LYS I   256                                                      
REMARK 465     GLU I   257                                                      
REMARK 465     SER I   296                                                      
REMARK 465     GLN I   297                                                      
REMARK 465     VAL I   298                                                      
REMARK 465     ARG I   299                                                      
REMARK 465     CYS I   300                                                      
REMARK 465     TYR I   301                                                      
REMARK 465     VAL I   302                                                      
REMARK 465     HIS I   303                                                      
REMARK 465     ILE I   304                                                      
REMARK 465     MET I   305                                                      
REMARK 465     LYS I   306                                                      
REMARK 465     GLU I   307                                                      
REMARK 465     GLY I   308                                                      
REMARK 465     LEU I   309                                                      
REMARK 465     CYS I   310                                                      
REMARK 465     SER I   311                                                      
REMARK 465     ARG I   312                                                      
REMARK 465     VAL I   313                                                      
REMARK 465     SER I   314                                                      
REMARK 465     THR I   315                                                      
REMARK 465     LEU I   316                                                      
REMARK 465     GLY I   317                                                      
REMARK 465     LEU I   318                                                      
REMARK 465     TYR I   319                                                      
REMARK 465     MET I   320                                                      
REMARK 465     GLU I   321                                                      
REMARK 465     ALA I   322                                                      
REMARK 465     ASN I   323                                                      
REMARK 465     ARG I   324                                                      
REMARK 465     GLN I   325                                                      
REMARK 465     VAL I   326                                                      
REMARK 465     PRO I   327                                                      
REMARK 465     LYS I   328                                                      
REMARK 465     LEU I   329                                                      
REMARK 465     LEU I   330                                                      
REMARK 465     SER I   331                                                      
REMARK 465     ALA I   332                                                      
REMARK 465     LEU I   333                                                      
REMARK 465     CYS I   334                                                      
REMARK 465     PRO I   335                                                      
REMARK 465     GLU I   336                                                      
REMARK 465     GLU I   337                                                      
REMARK 465     PRO I   338                                                      
REMARK 465     PRO I   339                                                      
REMARK 465     VAL I   340                                                      
REMARK 465     HIS I   341                                                      
REMARK 465     SER I   342                                                      
REMARK 465     SER I   343                                                      
REMARK 465     ALA I   344                                                      
REMARK 465     GLN I   345                                                      
REMARK 465     ILE I   346                                                      
REMARK 465     VAL I   347                                                      
REMARK 465     SER I   348                                                      
REMARK 465     LYS I   349                                                      
REMARK 465     HIS I   350                                                      
REMARK 465     LEU I   351                                                      
REMARK 465     VAL I   352                                                      
REMARK 465     GLY I   353                                                      
REMARK 465     VAL I   354                                                      
REMARK 465     ASP I   355                                                      
REMARK 465     SER I   356                                                      
REMARK 465     LEU I   357                                                      
REMARK 465     ILE I   358                                                      
REMARK 465     GLY I   359                                                      
REMARK 465     PRO I   360                                                      
REMARK 465     GLU I   361                                                      
REMARK 465     THR I   362                                                      
REMARK 465     GLN I   363                                                      
REMARK 465     ILE I   364                                                      
REMARK 465     GLY I   365                                                      
REMARK 465     GLU I   366                                                      
REMARK 465     LYS I   367                                                      
REMARK 465     SER I   368                                                      
REMARK 465     SER I   369                                                      
REMARK 465     ILE I   370                                                      
REMARK 465     LYS I   371                                                      
REMARK 465     ARG I   372                                                      
REMARK 465     SER I   373                                                      
REMARK 465     VAL I   374                                                      
REMARK 465     ILE I   375                                                      
REMARK 465     GLY I   376                                                      
REMARK 465     SER I   377                                                      
REMARK 465     SER I   378                                                      
REMARK 465     CYS I   379                                                      
REMARK 465     LEU I   380                                                      
REMARK 465     ILE I   381                                                      
REMARK 465     LYS I   382                                                      
REMARK 465     ASP I   383                                                      
REMARK 465     ARG I   384                                                      
REMARK 465     VAL I   385                                                      
REMARK 465     THR I   386                                                      
REMARK 465     ILE I   387                                                      
REMARK 465     THR I   388                                                      
REMARK 465     ASN I   389                                                      
REMARK 465     CYS I   390                                                      
REMARK 465     LEU I   391                                                      
REMARK 465     LEU I   392                                                      
REMARK 465     MET I   393                                                      
REMARK 465     ASN I   394                                                      
REMARK 465     SER I   395                                                      
REMARK 465     VAL I   396                                                      
REMARK 465     THR I   397                                                      
REMARK 465     VAL I   398                                                      
REMARK 465     GLU I   399                                                      
REMARK 465     GLU I   400                                                      
REMARK 465     GLY I   401                                                      
REMARK 465     SER I   402                                                      
REMARK 465     ASN I   403                                                      
REMARK 465     ILE I   404                                                      
REMARK 465     GLN I   405                                                      
REMARK 465     GLY I   406                                                      
REMARK 465     SER I   407                                                      
REMARK 465     VAL I   408                                                      
REMARK 465     ILE I   409                                                      
REMARK 465     CYS I   410                                                      
REMARK 465     ASN I   411                                                      
REMARK 465     ASN I   412                                                      
REMARK 465     ALA I   413                                                      
REMARK 465     VAL I   414                                                      
REMARK 465     ILE I   415                                                      
REMARK 465     GLU I   416                                                      
REMARK 465     LYS I   417                                                      
REMARK 465     GLY I   418                                                      
REMARK 465     ALA I   419                                                      
REMARK 465     ASP I   420                                                      
REMARK 465     ILE I   421                                                      
REMARK 465     LYS I   422                                                      
REMARK 465     ASP I   423                                                      
REMARK 465     CYS I   424                                                      
REMARK 465     LEU I   425                                                      
REMARK 465     ILE I   426                                                      
REMARK 465     GLY I   427                                                      
REMARK 465     SER I   428                                                      
REMARK 465     GLY I   429                                                      
REMARK 465     GLN I   430                                                      
REMARK 465     ARG I   431                                                      
REMARK 465     ILE I   432                                                      
REMARK 465     GLU I   433                                                      
REMARK 465     ALA I   434                                                      
REMARK 465     LYS I   435                                                      
REMARK 465     ALA I   436                                                      
REMARK 465     LYS I   437                                                      
REMARK 465     ARG I   438                                                      
REMARK 465     VAL I   439                                                      
REMARK 465     ASN I   440                                                      
REMARK 465     GLU I   441                                                      
REMARK 465     VAL I   442                                                      
REMARK 465     ILE I   443                                                      
REMARK 465     VAL I   444                                                      
REMARK 465     GLY I   445                                                      
REMARK 465     ASN I   446                                                      
REMARK 465     ASP I   447                                                      
REMARK 465     GLN I   448                                                      
REMARK 465     LEU I   449                                                      
REMARK 465     MET I   450                                                      
REMARK 465     GLU I   451                                                      
REMARK 465     ILE I   452                                                      
REMARK 465     GLY J    12                                                      
REMARK 465     GLY J    13                                                      
REMARK 465     SER J    14                                                      
REMARK 465     ARG J    15                                                      
REMARK 465     MET J    16                                                      
REMARK 465     THR J    17                                                      
REMARK 465     ASP J    18                                                      
REMARK 465     LEU J    19                                                      
REMARK 465     THR J    20                                                      
REMARK 465     SER J    21                                                      
REMARK 465     SER J    22                                                      
REMARK 465     ILE J    23                                                      
REMARK 465     PRO J    24                                                      
REMARK 465     LYS J    25                                                      
REMARK 465     PRO J    26                                                      
REMARK 465     LEU J    27                                                      
REMARK 465     GLY J   135                                                      
REMARK 465     GLN J   136                                                      
REMARK 465     ASP J   137                                                      
REMARK 465     SER J   138                                                      
REMARK 465     ILE J   139                                                      
REMARK 465     GLU J   140                                                      
REMARK 465     PRO J   141                                                      
REMARK 465     VAL J   142                                                      
REMARK 465     PRO J   143                                                      
REMARK 465     GLY J   144                                                      
REMARK 465     GLN J   145                                                      
REMARK 465     LYS J   146                                                      
REMARK 465     GLY J   147                                                      
REMARK 465     LYS J   148                                                      
REMARK 465     LYS J   149                                                      
REMARK 465     LYS J   150                                                      
REMARK 465     ALA J   151                                                      
REMARK 465     VAL J   152                                                      
REMARK 465     GLU J   153                                                      
REMARK 465     GLN J   154                                                      
REMARK 465     SER J   239                                                      
REMARK 465     ALA J   240                                                      
REMARK 465     SER J   241                                                      
REMARK 465     SER J   242                                                      
REMARK 465     GLN J   243                                                      
REMARK 465     GLN J   244                                                      
REMARK 465     GLY J   245                                                      
REMARK 465     GLN J   246                                                      
REMARK 465     GLU J   247                                                      
REMARK 465     GLU J   248                                                      
REMARK 465     LYS J   249                                                      
REMARK 465     GLU J   250                                                      
REMARK 465     GLU J   251                                                      
REMARK 465     ASP J   252                                                      
REMARK 465     LEU J   253                                                      
REMARK 465     LYS J   254                                                      
REMARK 465     LYS J   255                                                      
REMARK 465     LYS J   256                                                      
REMARK 465     GLU J   257                                                      
REMARK 465     SER J   296                                                      
REMARK 465     GLN J   297                                                      
REMARK 465     VAL J   298                                                      
REMARK 465     ARG J   299                                                      
REMARK 465     CYS J   300                                                      
REMARK 465     TYR J   301                                                      
REMARK 465     VAL J   302                                                      
REMARK 465     HIS J   303                                                      
REMARK 465     ILE J   304                                                      
REMARK 465     MET J   305                                                      
REMARK 465     LYS J   306                                                      
REMARK 465     GLU J   307                                                      
REMARK 465     GLY J   308                                                      
REMARK 465     LEU J   309                                                      
REMARK 465     CYS J   310                                                      
REMARK 465     SER J   311                                                      
REMARK 465     ARG J   312                                                      
REMARK 465     VAL J   313                                                      
REMARK 465     SER J   314                                                      
REMARK 465     THR J   315                                                      
REMARK 465     LEU J   316                                                      
REMARK 465     GLY J   317                                                      
REMARK 465     LEU J   318                                                      
REMARK 465     TYR J   319                                                      
REMARK 465     MET J   320                                                      
REMARK 465     GLU J   321                                                      
REMARK 465     ALA J   322                                                      
REMARK 465     ASN J   323                                                      
REMARK 465     ARG J   324                                                      
REMARK 465     GLN J   325                                                      
REMARK 465     VAL J   326                                                      
REMARK 465     PRO J   327                                                      
REMARK 465     LYS J   328                                                      
REMARK 465     LEU J   329                                                      
REMARK 465     LEU J   330                                                      
REMARK 465     SER J   331                                                      
REMARK 465     ALA J   332                                                      
REMARK 465     LEU J   333                                                      
REMARK 465     CYS J   334                                                      
REMARK 465     PRO J   335                                                      
REMARK 465     GLU J   336                                                      
REMARK 465     GLU J   337                                                      
REMARK 465     PRO J   338                                                      
REMARK 465     PRO J   339                                                      
REMARK 465     VAL J   340                                                      
REMARK 465     HIS J   341                                                      
REMARK 465     SER J   342                                                      
REMARK 465     SER J   343                                                      
REMARK 465     ALA J   344                                                      
REMARK 465     GLN J   345                                                      
REMARK 465     ILE J   346                                                      
REMARK 465     VAL J   347                                                      
REMARK 465     SER J   348                                                      
REMARK 465     LYS J   349                                                      
REMARK 465     HIS J   350                                                      
REMARK 465     LEU J   351                                                      
REMARK 465     VAL J   352                                                      
REMARK 465     GLY J   353                                                      
REMARK 465     VAL J   354                                                      
REMARK 465     ASP J   355                                                      
REMARK 465     SER J   356                                                      
REMARK 465     LEU J   357                                                      
REMARK 465     ILE J   358                                                      
REMARK 465     GLY J   359                                                      
REMARK 465     PRO J   360                                                      
REMARK 465     GLU J   361                                                      
REMARK 465     THR J   362                                                      
REMARK 465     GLN J   363                                                      
REMARK 465     ILE J   364                                                      
REMARK 465     GLY J   365                                                      
REMARK 465     GLU J   366                                                      
REMARK 465     LYS J   367                                                      
REMARK 465     SER J   368                                                      
REMARK 465     SER J   369                                                      
REMARK 465     ILE J   370                                                      
REMARK 465     LYS J   371                                                      
REMARK 465     ARG J   372                                                      
REMARK 465     SER J   373                                                      
REMARK 465     VAL J   374                                                      
REMARK 465     ILE J   375                                                      
REMARK 465     GLY J   376                                                      
REMARK 465     SER J   377                                                      
REMARK 465     SER J   378                                                      
REMARK 465     CYS J   379                                                      
REMARK 465     LEU J   380                                                      
REMARK 465     ILE J   381                                                      
REMARK 465     LYS J   382                                                      
REMARK 465     ASP J   383                                                      
REMARK 465     ARG J   384                                                      
REMARK 465     VAL J   385                                                      
REMARK 465     THR J   386                                                      
REMARK 465     ILE J   387                                                      
REMARK 465     THR J   388                                                      
REMARK 465     ASN J   389                                                      
REMARK 465     CYS J   390                                                      
REMARK 465     LEU J   391                                                      
REMARK 465     LEU J   392                                                      
REMARK 465     MET J   393                                                      
REMARK 465     ASN J   394                                                      
REMARK 465     SER J   395                                                      
REMARK 465     VAL J   396                                                      
REMARK 465     THR J   397                                                      
REMARK 465     VAL J   398                                                      
REMARK 465     GLU J   399                                                      
REMARK 465     GLU J   400                                                      
REMARK 465     GLY J   401                                                      
REMARK 465     SER J   402                                                      
REMARK 465     ASN J   403                                                      
REMARK 465     ILE J   404                                                      
REMARK 465     GLN J   405                                                      
REMARK 465     GLY J   406                                                      
REMARK 465     SER J   407                                                      
REMARK 465     VAL J   408                                                      
REMARK 465     ILE J   409                                                      
REMARK 465     CYS J   410                                                      
REMARK 465     ASN J   411                                                      
REMARK 465     ASN J   412                                                      
REMARK 465     ALA J   413                                                      
REMARK 465     VAL J   414                                                      
REMARK 465     ILE J   415                                                      
REMARK 465     GLU J   416                                                      
REMARK 465     LYS J   417                                                      
REMARK 465     GLY J   418                                                      
REMARK 465     ALA J   419                                                      
REMARK 465     ASP J   420                                                      
REMARK 465     ILE J   421                                                      
REMARK 465     LYS J   422                                                      
REMARK 465     ASP J   423                                                      
REMARK 465     CYS J   424                                                      
REMARK 465     LEU J   425                                                      
REMARK 465     ILE J   426                                                      
REMARK 465     GLY J   427                                                      
REMARK 465     SER J   428                                                      
REMARK 465     GLY J   429                                                      
REMARK 465     GLN J   430                                                      
REMARK 465     ARG J   431                                                      
REMARK 465     ILE J   432                                                      
REMARK 465     GLU J   433                                                      
REMARK 465     ALA J   434                                                      
REMARK 465     LYS J   435                                                      
REMARK 465     ALA J   436                                                      
REMARK 465     LYS J   437                                                      
REMARK 465     ARG J   438                                                      
REMARK 465     VAL J   439                                                      
REMARK 465     ASN J   440                                                      
REMARK 465     GLU J   441                                                      
REMARK 465     VAL J   442                                                      
REMARK 465     ILE J   443                                                      
REMARK 465     VAL J   444                                                      
REMARK 465     GLY J   445                                                      
REMARK 465     ASN J   446                                                      
REMARK 465     ASP J   447                                                      
REMARK 465     GLN J   448                                                      
REMARK 465     LEU J   449                                                      
REMARK 465     MET J   450                                                      
REMARK 465     GLU J   451                                                      
REMARK 465     ILE J   452                                                      
REMARK 465     PRO L     1                                                      
REMARK 465     GLY L     2                                                      
REMARK 465     THR L   278                                                      
REMARK 465     ASP L   279                                                      
REMARK 465     THR L   280                                                      
REMARK 465     ASP L   281                                                      
REMARK 465     GLU L   282                                                      
REMARK 465     THR L   283                                                      
REMARK 465     GLU L   284                                                      
REMARK 465     LEU L   285                                                      
REMARK 465     ALA L   286                                                      
REMARK 465     ARG L   287                                                      
REMARK 465     GLN L   288                                                      
REMARK 465     MET L   289                                                      
REMARK 465     GLU L   290                                                      
REMARK 465     ARG L   291                                                      
REMARK 465     LEU L   292                                                      
REMARK 465     GLU L   293                                                      
REMARK 465     ARG L   294                                                      
REMARK 465     GLU L   295                                                      
REMARK 465     ASN L   296                                                      
REMARK 465     ALA L   297                                                      
REMARK 465     GLU L   298                                                      
REMARK 465     VAL L   299                                                      
REMARK 465     ASP L   300                                                      
REMARK 465     GLY L   301                                                      
REMARK 465     ASP L   302                                                      
REMARK 465     ASP L   303                                                      
REMARK 465     ASP L   304                                                      
REMARK 465     ALA L   305                                                      
REMARK 465     GLU L   306                                                      
REMARK 465     GLU L   307                                                      
REMARK 465     MET L   308                                                      
REMARK 465     GLU L   309                                                      
REMARK 465     ALA L   310                                                      
REMARK 465     LYS L   311                                                      
REMARK 465     ALA L   312                                                      
REMARK 465     GLU L   313                                                      
REMARK 465     ASP L   314                                                      
REMARK 465     MET S     1                                                      
REMARK 465     ALA S     2                                                      
REMARK 465     GLY S     3                                                      
REMARK 465     GLY S     4                                                      
REMARK 465     GLU S     5                                                      
REMARK 465     ALA S     6                                                      
REMARK 465     GLY S     7                                                      
REMARK 465     VAL S     8                                                      
REMARK 465     THR S     9                                                      
REMARK 465     LEU S    10                                                      
REMARK 465     GLY S    11                                                      
REMARK 465     GLN S    12                                                      
REMARK 465     PRO S    13                                                      
REMARK 465     HIS S    14                                                      
REMARK 465     LEU S    15                                                      
REMARK 465     SER S    16                                                      
REMARK 465     ARG S    17                                                      
REMARK 465     GLN S    18                                                      
REMARK 465     ASP S    19                                                      
REMARK 465     ASP S    92                                                      
REMARK 465     ASP S    93                                                      
REMARK 465     PRO S    94                                                      
REMARK 465     SER S    95                                                      
REMARK 465     CYS S    96                                                      
REMARK 465     PRO S    97                                                      
REMARK 465     ARG S    98                                                      
REMARK 465     PRO S    99                                                      
REMARK 465     GLU S   100                                                      
REMARK 465     CYS S   101                                                      
REMARK 465     TYR S   102                                                      
REMARK 465     ARG S   103                                                      
REMARK 465     SER S   104                                                      
REMARK 465     CYS S   105                                                      
REMARK 465     GLY S   106                                                      
REMARK 465     SER S   107                                                      
REMARK 465     SER S   108                                                      
REMARK 465     THR S   109                                                      
REMARK 465     PRO S   110                                                      
REMARK 465     ASP S   111                                                      
REMARK 465     GLU S   112                                                      
REMARK 465     PHE S   113                                                      
REMARK 465     PRO S   114                                                      
REMARK 465     THR S   115                                                      
REMARK 465     ASP S   116                                                      
REMARK 465     ILE S   117                                                      
REMARK 465     PRO S   118                                                      
REMARK 465     GLY S   119                                                      
REMARK 465     THR S   120                                                      
REMARK 465     LYS S   121                                                      
REMARK 465     GLY S   122                                                      
REMARK 465     MET S   180                                                      
REMARK 465     LYS S   181                                                      
REMARK 465     LEU S   182                                                      
REMARK 465     LYS S   183                                                      
REMARK 465     ILE S   224                                                      
REMARK 465     SER S   225                                                      
REMARK 465     ALA S   226                                                      
REMARK 465     GLN S   227                                                      
REMARK 465     VAL S   469                                                      
REMARK 465     ASP S   470                                                      
REMARK 465     ASP S   471                                                      
REMARK 465     ASP S   472                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     ARG A  54    NH1  NH2                                            
REMARK 470     ARG A  55    NH1  NH2                                            
REMARK 470     ARG A  65    NH1  NH2                                            
REMARK 470     TYR A  78    OH                                                  
REMARK 470     TRP A  97    CH2                                                 
REMARK 470     TRP A 111    CH2                                                 
REMARK 470     ARG A 113    NH1  NH2                                            
REMARK 470     ARG A 121    NH1  NH2                                            
REMARK 470     GLU A 126    CG   CD   OE1  OE2                                  
REMARK 470     LEU A 127    CG   CD1  CD2                                       
REMARK 470     TYR A 128    OH                                                  
REMARK 470     ARG A 129    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG A 136    NH1  NH2                                            
REMARK 470     ARG A 145    NH1  NH2                                            
REMARK 470     TYR A 152    OH                                                  
REMARK 470     ARG A 163    NH1  NH2                                            
REMARK 470     ARG A 169    NH1  NH2                                            
REMARK 470     ARG A 171    NH1  NH2                                            
REMARK 470     ARG A 172    NH1  NH2                                            
REMARK 470     LYS A 176    CG   CD   CE   NZ                                   
REMARK 470     ASN A 177    CG   OD1  ND2                                       
REMARK 470     VAL A 178    CG1  CG2                                            
REMARK 470     ARG A 195    NH1  NH2                                            
REMARK 470     ARG A 211    NH1  NH2                                            
REMARK 470     GLN A 219    CG   CD   OE1  NE2                                  
REMARK 470     LEU A 221    CG   CD1  CD2                                       
REMARK 470     ARG A 222    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG A 223    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     SER A 229    OG                                                  
REMARK 470     GLN A 232    CG   CD   OE1  NE2                                  
REMARK 470     SER A 234    OG                                                  
REMARK 470     SER A 235    OG                                                  
REMARK 470     ASP A 236    CG   OD1  OD2                                       
REMARK 470     ARG A 241    NH1  NH2                                            
REMARK 470     TYR A 242    OH                                                  
REMARK 470     TYR A 266    OH                                                  
REMARK 470     ARG A 269    NH1  NH2                                            
REMARK 470     ARG A 274    NH1  NH2                                            
REMARK 470     ASN A 279    CG   OD1  ND2                                       
REMARK 470     LYS A 294    CG   CD   CE   NZ                                   
REMARK 470     TYR A 296    OH                                                  
REMARK 470     ARG A 299    NH1  NH2                                            
REMARK 470     TYR A 306    OH                                                  
REMARK 470     ARG A 315    NH1  NH2                                            
REMARK 470     ARG A 316    NH1  NH2                                            
REMARK 470     TRP A 317    CH2                                                 
REMARK 470     TYR A 319    OH                                                  
REMARK 470     ARG A 339    NH1  NH2                                            
REMARK 470     TYR A 343    OH                                                  
REMARK 470     ARG A 344    NH1  NH2                                            
REMARK 470     GLU A 347    CG   CD   OE1  OE2                                  
REMARK 470     TYR A 395    OH                                                  
REMARK 470     TRP A 397    CH2                                                 
REMARK 470     ARG A 401    NH1  NH2                                            
REMARK 470     GLU A 421    CG   CD   OE1  OE2                                  
REMARK 470     ARG A 422    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG A 428    NH1  NH2                                            
REMARK 470     GLN A 434    CG   CD   OE1  NE2                                  
REMARK 470     ASN A 440    CG   OD1  ND2                                       
REMARK 470     ILE A 441    CG1  CG2  CD1                                       
REMARK 470     GLU A 445    CG   CD   OE1  OE2                                  
REMARK 470     ASP A 455    CG   OD1  OD2                                       
REMARK 470     GLU A 457    CG   CD   OE1  OE2                                  
REMARK 470     GLU A 458    CG   CD   OE1  OE2                                  
REMARK 470     GLU A 460    CG   CD   OE1  OE2                                  
REMARK 470     ASP A 461    CG   OD1  OD2                                       
REMARK 470     ASP A 462    CG   OD1  OD2                                       
REMARK 470     GLU A 464    CG   CD   OE1  OE2                                  
REMARK 470     PHE A 465    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     SER A 466    OG                                                  
REMARK 470     ARG B  54    NH1  NH2                                            
REMARK 470     ARG B  55    NH1  NH2                                            
REMARK 470     ARG B  65    NH1  NH2                                            
REMARK 470     TYR B  78    OH                                                  
REMARK 470     TRP B  97    CH2                                                 
REMARK 470     TRP B 111    CH2                                                 
REMARK 470     ARG B 113    NH1  NH2                                            
REMARK 470     ARG B 121    NH1  NH2                                            
REMARK 470     GLU B 126    CG   CD   OE1  OE2                                  
REMARK 470     LEU B 127    CG   CD1  CD2                                       
REMARK 470     TYR B 128    OH                                                  
REMARK 470     ARG B 129    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG B 136    NH1  NH2                                            
REMARK 470     ARG B 145    NH1  NH2                                            
REMARK 470     TYR B 152    OH                                                  
REMARK 470     ARG B 163    NH1  NH2                                            
REMARK 470     ARG B 169    NH1  NH2                                            
REMARK 470     ARG B 171    NH1  NH2                                            
REMARK 470     ARG B 172    NH1  NH2                                            
REMARK 470     LYS B 176    CG   CD   CE   NZ                                   
REMARK 470     ASN B 177    CG   OD1  ND2                                       
REMARK 470     VAL B 178    CG1  CG2                                            
REMARK 470     ARG B 195    NH1  NH2                                            
REMARK 470     ARG B 211    NH1  NH2                                            
REMARK 470     GLN B 219    CG   CD   OE1  NE2                                  
REMARK 470     LEU B 221    CG   CD1  CD2                                       
REMARK 470     ARG B 222    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG B 223    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     SER B 229    OG                                                  
REMARK 470     GLN B 232    CG   CD   OE1  NE2                                  
REMARK 470     SER B 234    OG                                                  
REMARK 470     SER B 235    OG                                                  
REMARK 470     ASP B 236    CG   OD1  OD2                                       
REMARK 470     ARG B 241    NH1  NH2                                            
REMARK 470     TYR B 242    OH                                                  
REMARK 470     TYR B 266    OH                                                  
REMARK 470     ARG B 269    NH1  NH2                                            
REMARK 470     ARG B 274    NH1  NH2                                            
REMARK 470     ASN B 279    CG   OD1  ND2                                       
REMARK 470     LYS B 294    CG   CD   CE   NZ                                   
REMARK 470     TYR B 296    OH                                                  
REMARK 470     ARG B 299    NH1  NH2                                            
REMARK 470     TYR B 306    OH                                                  
REMARK 470     ARG B 315    NH1  NH2                                            
REMARK 470     ARG B 316    NH1  NH2                                            
REMARK 470     TRP B 317    CH2                                                 
REMARK 470     TYR B 319    OH                                                  
REMARK 470     ARG B 339    NH1  NH2                                            
REMARK 470     TYR B 343    OH                                                  
REMARK 470     ARG B 344    NH1  NH2                                            
REMARK 470     GLU B 347    CG   CD   OE1  OE2                                  
REMARK 470     TYR B 395    OH                                                  
REMARK 470     TRP B 397    CH2                                                 
REMARK 470     ARG B 401    NH1  NH2                                            
REMARK 470     GLU B 421    CG   CD   OE1  OE2                                  
REMARK 470     ARG B 422    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG B 428    NH1  NH2                                            
REMARK 470     GLN B 434    CG   CD   OE1  NE2                                  
REMARK 470     ASN B 440    CG   OD1  ND2                                       
REMARK 470     ILE B 441    CG1  CG2  CD1                                       
REMARK 470     GLU B 445    CG   CD   OE1  OE2                                  
REMARK 470     ASP B 455    CG   OD1  OD2                                       
REMARK 470     GLU B 457    CG   CD   OE1  OE2                                  
REMARK 470     GLU B 458    CG   CD   OE1  OE2                                  
REMARK 470     GLU B 460    CG   CD   OE1  OE2                                  
REMARK 470     ASP B 461    CG   OD1  OD2                                       
REMARK 470     ASP B 462    CG   OD1  OD2                                       
REMARK 470     GLU B 464    CG   CD   OE1  OE2                                  
REMARK 470     PHE B 465    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     SER B 466    OG                                                  
REMARK 470     ASP B 549    CG   OD1  OD2                                       
REMARK 470     ILE B 550    CG1  CG2  CD1                                       
REMARK 470     LYS B 551    CG   CD   CE   NZ                                   
REMARK 470     VAL B 552    CG1  CG2                                            
REMARK 470     PHE B 553    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     GLN B 554    CG   CD   OE1  NE2                                  
REMARK 470     ASN B 555    CG   OD1  ND2                                       
REMARK 470     GLU B 556    CG   CD   OE1  OE2                                  
REMARK 470     VAL B 557    CG1  CG2                                            
REMARK 470     LEU B 558    CG   CD1  CD2                                       
REMARK 470     THR B 560    OG1  CG2                                            
REMARK 470     LEU B 561    CG   CD1  CD2                                       
REMARK 470     GLN B 562    CG   CD   OE1  NE2                                  
REMARK 470     ARG B 563    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS B 565    CG   CD   CE   NZ                                   
REMARK 470     GLU B 566    CG   CD   OE1  OE2                                  
REMARK 470     GLU B 567    CG   CD   OE1  OE2                                  
REMARK 470     ASN B 568    CG   OD1  ND2                                       
REMARK 470     ILE B 569    CG1  CG2  CD1                                       
REMARK 470     SER B 570    OG                                                  
REMARK 470     CYS B 571    SG                                                  
REMARK 470     ASP B 572    CG   OD1  OD2                                       
REMARK 470     ASN B 573    CG   OD1  ND2                                       
REMARK 470     LEU B 574    CG   CD1  CD2                                       
REMARK 470     VAL B 575    CG1  CG2                                            
REMARK 470     LEU B 576    CG   CD1  CD2                                       
REMARK 470     GLU B 577    CG   CD   OE1  OE2                                  
REMARK 470     ILE B 578    CG1  CG2  CD1                                       
REMARK 470     ASN B 579    CG   OD1  ND2                                       
REMARK 470     SER B 580    OG                                                  
REMARK 470     LEU B 581    CG   CD1  CD2                                       
REMARK 470     LYS B 582    CG   CD   CE   NZ                                   
REMARK 470     TYR B 583    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     TYR B 585    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     ASN B 586    CG   OD1  ND2                                       
REMARK 470     ILE B 587    CG1  CG2  CD1                                       
REMARK 470     SER B 588    OG                                                  
REMARK 470     LEU B 589    CG   CD1  CD2                                       
REMARK 470     LYS B 590    CG   CD   CE   NZ                                   
REMARK 470     GLU B 591    CG   CD   OE1  OE2                                  
REMARK 470     VAL B 592    CG1  CG2                                            
REMARK 470     MET B 593    CG   SD   CE                                        
REMARK 470     GLN B 594    CG   CD   OE1  NE2                                  
REMARK 470     VAL B 595    CG1  CG2                                            
REMARK 470     LEU B 596    CG   CD1  CD2                                       
REMARK 470     SER B 597    OG                                                  
REMARK 470     HIS B 598    CG   ND1  CD2  CE1  NE2                             
REMARK 470     VAL B 599    CG1  CG2                                            
REMARK 470     VAL B 600    CG1  CG2                                            
REMARK 470     LEU B 601    CG   CD1  CD2                                       
REMARK 470     GLU B 602    CG   CD   OE1  OE2                                  
REMARK 470     PHE B 603    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     PRO B 604    CG   CD                                             
REMARK 470     LEU B 605    CG   CD1  CD2                                       
REMARK 470     GLN B 606    CG   CD   OE1  NE2                                  
REMARK 470     GLN B 607    CG   CD   OE1  NE2                                  
REMARK 470     MET B 608    CG   SD   CE                                        
REMARK 470     ASP B 609    CG   OD1  OD2                                       
REMARK 470     SER B 610    OG                                                  
REMARK 470     PRO B 611    CG   CD                                             
REMARK 470     LEU B 612    CG   CD1  CD2                                       
REMARK 470     ASP B 613    CG   OD1  OD2                                       
REMARK 470     SER B 614    OG                                                  
REMARK 470     SER B 615    OG                                                  
REMARK 470     ARG B 616    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     TYR B 617    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     CYS B 618    SG                                                  
REMARK 470     LEU B 620    CG   CD1  CD2                                       
REMARK 470     LEU B 621    CG   CD1  CD2                                       
REMARK 470     LEU B 622    CG   CD1  CD2                                       
REMARK 470     PRO B 623    CG   CD                                             
REMARK 470     LEU B 624    CG   CD1  CD2                                       
REMARK 470     LEU B 625    CG   CD1  CD2                                       
REMARK 470     LYS B 626    CG   CD   CE   NZ                                   
REMARK 470     TRP B 628    CH2                                                 
REMARK 470     SER B 629    OG                                                  
REMARK 470     PRO B 630    CG   CD                                             
REMARK 470     VAL B 631    CG1  CG2                                            
REMARK 470     PHE B 632    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ARG B 633    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASN B 634    CG   OD1  ND2                                       
REMARK 470     TYR B 635    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     ILE B 636    CG1  CG2  CD1                                       
REMARK 470     LYS B 637    CG   CD   CE   NZ                                   
REMARK 470     ARG B 638    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP B 641    CG   OD1  OD2                                       
REMARK 470     HIS B 642    CG   ND1  CD2  CE1  NE2                             
REMARK 470     LEU B 643    CG   CD1  CD2                                       
REMARK 470     GLU B 644    CG   CD   OE1  OE2                                  
REMARK 470     LEU B 646    CG   CD1  CD2                                       
REMARK 470     ILE B 649    CG1  CG2  CD1                                       
REMARK 470     GLU B 650    CG   CD   OE1  OE2                                  
REMARK 470     ASP B 651    CG   OD1  OD2                                       
REMARK 470     PHE B 652    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     PHE B 653    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     LEU B 654    CG   CD1  CD2                                       
REMARK 470     GLU B 655    CG   CD   OE1  OE2                                  
REMARK 470     HIS B 656    CG   ND1  CD2  CE1  NE2                             
REMARK 470     GLU B 657    CG   CD   OE1  OE2                                  
REMARK 470     LEU B 659    CG   CD1  CD2                                       
REMARK 470     ILE B 661    CG1  CG2  CD1                                       
REMARK 470     SER B 662    OG                                                  
REMARK 470     MET B 663    CG   SD   CE                                        
REMARK 470     LYS B 665    CG   CD   CE   NZ                                   
REMARK 470     VAL B 666    CG1  CG2                                            
REMARK 470     LEU B 667    CG   CD1  CD2                                       
REMARK 470     MET B 668    CG   SD   CE                                        
REMARK 470     PHE B 670    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     TYR B 671    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     GLN B 672    CG   CD   OE1  NE2                                  
REMARK 470     LEU B 673    CG   CD1  CD2                                       
REMARK 470     GLU B 674    CG   CD   OE1  OE2                                  
REMARK 470     ILE B 675    CG1  CG2  CD1                                       
REMARK 470     LEU B 676    CG   CD1  CD2                                       
REMARK 470     GLU B 678    CB   CG   CD   OE1  OE2                             
REMARK 470     GLU B 679    CG   CD   OE1  OE2                                  
REMARK 470     THR B 680    OG1  CG2                                            
REMARK 470     ILE B 681    CG1  CG2  CD1                                       
REMARK 470     LEU B 682    CG   CD1  CD2                                       
REMARK 470     SER B 683    OG                                                  
REMARK 470     TRP B 684    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
REMARK 470     TRP B 684    CZ3  CH2                                            
REMARK 470     PHE B 685    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     SER B 686    OG                                                  
REMARK 470     GLN B 687    CG   CD   OE1  NE2                                  
REMARK 470     ARG B 688    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP B 692    CG   OD1  OD2                                       
REMARK 470     LYS B 693    CG   CD   CE   NZ                                   
REMARK 470     GLN B 695    CG   CD   OE1  NE2                                  
REMARK 470     GLN B 696    CG   CD   OE1  NE2                                  
REMARK 470     LEU B 697    CG   CD1  CD2                                       
REMARK 470     ARG B 698    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS B 699    CG   CD   CE   NZ                                   
REMARK 470     ASN B 700    CG   OD1  ND2                                       
REMARK 470     GLN B 701    CG   CD   OE1  NE2                                  
REMARK 470     GLN B 702    CG   CD   OE1  NE2                                  
REMARK 470     LEU B 703    CG   CD1  CD2                                       
REMARK 470     GLN B 704    CG   CD   OE1  NE2                                  
REMARK 470     ARG B 705    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     PHE B 706    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ILE B 707    CG1  CG2  CD1                                       
REMARK 470     GLN B 708    CG   CD   OE1  NE2                                  
REMARK 470     TRP B 709    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
REMARK 470     TRP B 709    CZ3  CH2                                            
REMARK 470     LEU B 710    CG   CD1  CD2                                       
REMARK 470     LYS B 711    CG   CD   CE   NZ                                   
REMARK 470     GLU B 712    CG   CD   OE1  OE2                                  
REMARK 470     GLU B 714    CG   CD   OE1  OE2                                  
REMARK 470     GLU B 715    CB   CG   CD   OE1  OE2                             
REMARK 470     ARG C  14    NH1  NH2                                            
REMARK 470     ARG C  24    NH1  NH2                                            
REMARK 470     ARG C  29    NH1  NH2                                            
REMARK 470     ARG C  36    NH1  NH2                                            
REMARK 470     ARG C  43    NH1  NH2                                            
REMARK 470     ARG C  50    NH1  NH2                                            
REMARK 470     TRP C  51    CH2                                                 
REMARK 470     ARG C  62    NH1  NH2                                            
REMARK 470     ARG C  63    NH1  NH2                                            
REMARK 470     ARG C  66    NH1  NH2                                            
REMARK 470     ARG C  67    NH1  NH2                                            
REMARK 470     ARG C  83    NH1  NH2                                            
REMARK 470     ARG C  84    NH1  NH2                                            
REMARK 470     ARG C  90    NH1  NH2                                            
REMARK 470     TYR C  93    OH                                                  
REMARK 470     ARG C  95    NH1  NH2                                            
REMARK 470     TYR C 126    OH                                                  
REMARK 470     ARG C 172    NH1  NH2                                            
REMARK 470     ARG C 183    NH1  NH2                                            
REMARK 470     ARG C 185    NH1  NH2                                            
REMARK 470     ARG C 228    NH1  NH2                                            
REMARK 470     ARG C 246    NH1  NH2                                            
REMARK 470     ASN C 280    CG   OD1  ND2                                       
REMARK 470     GLU C 281    CG   CD   OE1  OE2                                  
REMARK 470     GLU C 282    CG   CD   OE1  OE2                                  
REMARK 470     ASP C 283    CG   OD1  OD2                                       
REMARK 470     TYR C 315    OH                                                  
REMARK 470     TYR C 335    OH                                                  
REMARK 470     TYR C 337    OH                                                  
REMARK 470     ARG C 338    NH1  NH2                                            
REMARK 470     TYR C 344    OH                                                  
REMARK 470     ARG D  14    NH1  NH2                                            
REMARK 470     ARG D  24    NH1  NH2                                            
REMARK 470     ARG D  29    NH1  NH2                                            
REMARK 470     ARG D  36    NH1  NH2                                            
REMARK 470     ARG D  43    NH1  NH2                                            
REMARK 470     ARG D  50    NH1  NH2                                            
REMARK 470     TRP D  51    CH2                                                 
REMARK 470     ARG D  62    NH1  NH2                                            
REMARK 470     ARG D  63    NH1  NH2                                            
REMARK 470     ARG D  66    NH1  NH2                                            
REMARK 470     ARG D  67    NH1  NH2                                            
REMARK 470     ARG D  83    NH1  NH2                                            
REMARK 470     ARG D  84    NH1  NH2                                            
REMARK 470     ARG D  90    NH1  NH2                                            
REMARK 470     TYR D  93    OH                                                  
REMARK 470     ARG D  95    NH1  NH2                                            
REMARK 470     TYR D 126    OH                                                  
REMARK 470     ARG D 172    NH1  NH2                                            
REMARK 470     ARG D 183    NH1  NH2                                            
REMARK 470     ARG D 185    NH1  NH2                                            
REMARK 470     ARG D 228    NH1  NH2                                            
REMARK 470     ARG D 246    NH1  NH2                                            
REMARK 470     ASN D 280    CG   OD1  ND2                                       
REMARK 470     GLU D 281    CG   CD   OE1  OE2                                  
REMARK 470     GLU D 282    CG   CD   OE1  OE2                                  
REMARK 470     ASP D 283    CG   OD1  OD2                                       
REMARK 470     TYR D 315    OH                                                  
REMARK 470     TYR D 335    OH                                                  
REMARK 470     TYR D 337    OH                                                  
REMARK 470     ARG D 338    NH1  NH2                                            
REMARK 470     TYR D 344    OH                                                  
REMARK 470     ARG E 170    NH1  NH2                                            
REMARK 470     TYR E 173    OH                                                  
REMARK 470     TYR E 186    OH                                                  
REMARK 470     ARG E 188    NH1  NH2                                            
REMARK 470     ARG E 209    NH1  NH2                                            
REMARK 470     TYR E 214    OH                                                  
REMARK 470     ARG E 225    NH1  NH2                                            
REMARK 470     ARG E 231    NH1  NH2                                            
REMARK 470     TYR E 240    OH                                                  
REMARK 470     ARG E 250    NH1  NH2                                            
REMARK 470     TYR E 259    OH                                                  
REMARK 470     ARG E 267    NH1  NH2                                            
REMARK 470     ARG E 292    NH1  NH2                                            
REMARK 470     ARG E 301    NH1  NH2                                            
REMARK 470     ARG E 306    NH1  NH2                                            
REMARK 470     TYR E 307    OH                                                  
REMARK 470     ARG E 321    NH1  NH2                                            
REMARK 470     TYR E 324    OH                                                  
REMARK 470     TYR E 336    OH                                                  
REMARK 470     ARG E 344    NH1  NH2                                            
REMARK 470     TRP E 350    CH2                                                 
REMARK 470     ARG E 354    NH1  NH2                                            
REMARK 470     ARG E 355    NH1  NH2                                            
REMARK 470     ARG E 357    NH1  NH2                                            
REMARK 470     ARG E 364    NH1  NH2                                            
REMARK 470     TRP E 366    CH2                                                 
REMARK 470     ARG E 370    NH1  NH2                                            
REMARK 470     ARG E 374    NH1  NH2                                            
REMARK 470     TYR E 385    OH                                                  
REMARK 470     TYR E 393    OH                                                  
REMARK 470     ARG E 417    NH1  NH2                                            
REMARK 470     ARG E 428    NH1  NH2                                            
REMARK 470     TYR E 441    OH                                                  
REMARK 470     ARG E 446    NH1  NH2                                            
REMARK 470     ARG E 467    NH1  NH2                                            
REMARK 470     TRP E 476    CH2                                                 
REMARK 470     ARG E 483    NH1  NH2                                            
REMARK 470     TYR E 489    OH                                                  
REMARK 470     ARG E 517    NH1  NH2                                            
REMARK 470     ASP E 522    CB   CG   OD1  OD2                                  
REMARK 470     ARG F 170    NH1  NH2                                            
REMARK 470     TYR F 173    OH                                                  
REMARK 470     TYR F 186    OH                                                  
REMARK 470     ARG F 188    NH1  NH2                                            
REMARK 470     ARG F 209    NH1  NH2                                            
REMARK 470     TYR F 214    OH                                                  
REMARK 470     ARG F 225    NH1  NH2                                            
REMARK 470     ARG F 231    NH1  NH2                                            
REMARK 470     TYR F 240    OH                                                  
REMARK 470     ARG F 250    NH1  NH2                                            
REMARK 470     TYR F 259    OH                                                  
REMARK 470     ARG F 267    NH1  NH2                                            
REMARK 470     ARG F 292    NH1  NH2                                            
REMARK 470     ARG F 301    NH1  NH2                                            
REMARK 470     ARG F 306    NH1  NH2                                            
REMARK 470     TYR F 307    OH                                                  
REMARK 470     ARG F 321    NH1  NH2                                            
REMARK 470     TYR F 324    OH                                                  
REMARK 470     TYR F 336    OH                                                  
REMARK 470     ARG F 344    NH1  NH2                                            
REMARK 470     TRP F 350    CH2                                                 
REMARK 470     ARG F 354    NH1  NH2                                            
REMARK 470     ARG F 355    NH1  NH2                                            
REMARK 470     ARG F 357    NH1  NH2                                            
REMARK 470     ARG F 364    NH1  NH2                                            
REMARK 470     TRP F 366    CH2                                                 
REMARK 470     ARG F 370    NH1  NH2                                            
REMARK 470     ARG F 374    NH1  NH2                                            
REMARK 470     TYR F 385    OH                                                  
REMARK 470     TYR F 393    OH                                                  
REMARK 470     ARG F 417    NH1  NH2                                            
REMARK 470     ARG F 428    NH1  NH2                                            
REMARK 470     TYR F 441    OH                                                  
REMARK 470     ARG F 446    NH1  NH2                                            
REMARK 470     ARG F 467    NH1  NH2                                            
REMARK 470     TRP F 476    CH2                                                 
REMARK 470     ARG F 483    NH1  NH2                                            
REMARK 470     TYR F 489    OH                                                  
REMARK 470     ARG F 517    NH1  NH2                                            
REMARK 470     ASP F 522    CG   OD1  OD2                                       
REMARK 470     LYS G   4    CG   CD   CE   NZ                                   
REMARK 470     GLU G   5    CG   CD   OE1  OE2                                  
REMARK 470     LEU G   6    CG   CD1  CD2                                       
REMARK 470     ILE G   7    CG1  CG2  CD1                                       
REMARK 470     GLU G   8    CG   CD   OE1  OE2                                  
REMARK 470     TYR G   9    OH                                                  
REMARK 470     SER G  12    OG                                                  
REMARK 470     MET G  14    CG   SD   CE                                        
REMARK 470     LYS G  15    CG   CD   CE   NZ                                   
REMARK 470     GLU G  16    CG   CD   OE1  OE2                                  
REMARK 470     ARG G  28    NH1  NH2                                            
REMARK 470     LEU G  34    CG   CD1  CD2                                       
REMARK 470     LYS G  35    CG   CD   CE   NZ                                   
REMARK 470     ARG G  36    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP G  37    CG   OD1  OD2                                       
REMARK 470     LYS G  38    CG   CD   CE   NZ                                   
REMARK 470     GLU G  40    CG   CD   OE1  OE2                                  
REMARK 470     THR G  41    OG1  CG2                                            
REMARK 470     ILE G  42    CG1  CG2  CD1                                       
REMARK 470     GLN G  43    CG   CD   OE1  NE2                                  
REMARK 470     GLY G  44    O                                                   
REMARK 470     LEU G  45    CG   CD1  CD2                                       
REMARK 470     ARG G  46    NH1  NH2                                            
REMARK 470     ASN G  48    CG   OD1  ND2                                       
REMARK 470     THR G  50    OG1  CG2                                            
REMARK 470     SER G  51    OG                                                  
REMARK 470     GLU G  54    CG   CD   OE1  OE2                                  
REMARK 470     THR G  55    OG1  CG2                                            
REMARK 470     CYS G  57    SG                                                  
REMARK 470     VAL G  59    CG1  CG2                                            
REMARK 470     ASP G  60    CG   OD1  OD2                                       
REMARK 470     LEU G  73    CG   CD1  CD2                                       
REMARK 470     ARG G  74    NH1  NH2                                            
REMARK 470     ILE G  76    CG1  CG2  CD1                                       
REMARK 470     SER G  80    OG                                                  
REMARK 470     LEU G  81    CG   CD1  CD2                                       
REMARK 470     GLU G  82    CG   CD   OE1  OE2                                  
REMARK 470     TYR G  83    OH                                                  
REMARK 470     SER G  84    OG                                                  
REMARK 470     ASP G  85    CG   OD1  OD2                                       
REMARK 470     TYR G  86    OH                                                  
REMARK 470     SER G  87    OG                                                  
REMARK 470     LYS G  88    CG   CD   CE   NZ                                   
REMARK 470     CYS G  89    SG                                                  
REMARK 470     LYS G  90    CG   CD   CE   NZ                                   
REMARK 470     LYS G  91    CG   CD   CE   NZ                                   
REMARK 470     ILE G  92    CG1  CG2  CD1                                       
REMARK 470     ILE G  94    CG1  CG2  CD1                                       
REMARK 470     GLU G  95    CG   CD   OE1  OE2                                  
REMARK 470     ARG G  96    NH1  NH2                                            
REMARK 470     GLU G  98    CG   CD   OE1  OE2                                  
REMARK 470     ARG G 102    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG G 103    NH1  NH2                                            
REMARK 470     ARG G 108    NH1  NH2                                            
REMARK 470     LYS G 110    CG   CD   CE   NZ                                   
REMARK 470     TYR G 130    OH                                                  
REMARK 470     ARG G 132    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG G 136    NH1  NH2                                            
REMARK 470     LYS G 145    CG   CD   CE   NZ                                   
REMARK 470     ARG G 147    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     TYR G 151    OH                                                  
REMARK 470     ASN G 172    CG   OD1  ND2                                       
REMARK 470     VAL G 173    CG1  CG2                                            
REMARK 470     TYR G 185    OH                                                  
REMARK 470     TYR G 227    OH                                                  
REMARK 470     ARG G 237    NH1  NH2                                            
REMARK 470     TYR G 252    OH                                                  
REMARK 470     TYR G 275    OH                                                  
REMARK 470     TYR G 304    OH                                                  
REMARK 470     LYS H   4    CG   CD   CE   NZ                                   
REMARK 470     GLU H   5    CG   CD   OE1  OE2                                  
REMARK 470     LEU H   6    CG   CD1  CD2                                       
REMARK 470     ILE H   7    CG1  CG2  CD1                                       
REMARK 470     GLU H   8    CG   CD   OE1  OE2                                  
REMARK 470     TYR H   9    OH                                                  
REMARK 470     SER H  12    OG                                                  
REMARK 470     MET H  14    CG   SD   CE                                        
REMARK 470     LYS H  15    CG   CD   CE   NZ                                   
REMARK 470     GLU H  16    CG   CD   OE1  OE2                                  
REMARK 470     ARG H  28    NH1  NH2                                            
REMARK 470     LEU H  34    CG   CD1  CD2                                       
REMARK 470     LYS H  35    CG   CD   CE   NZ                                   
REMARK 470     ARG H  36    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP H  37    CG   OD1  OD2                                       
REMARK 470     LYS H  38    CG   CD   CE   NZ                                   
REMARK 470     GLU H  40    CG   CD   OE1  OE2                                  
REMARK 470     THR H  41    OG1  CG2                                            
REMARK 470     ILE H  42    CG1  CG2  CD1                                       
REMARK 470     GLN H  43    CG   CD   OE1  NE2                                  
REMARK 470     GLY H  44    O                                                   
REMARK 470     LEU H  45    CG   CD1  CD2                                       
REMARK 470     ARG H  46    NH1  NH2                                            
REMARK 470     ASN H  48    CG   OD1  ND2                                       
REMARK 470     THR H  50    OG1  CG2                                            
REMARK 470     SER H  51    OG                                                  
REMARK 470     GLU H  54    CG   CD   OE1  OE2                                  
REMARK 470     THR H  55    OG1  CG2                                            
REMARK 470     CYS H  57    SG                                                  
REMARK 470     VAL H  59    CG1  CG2                                            
REMARK 470     ASP H  60    CG   OD1  OD2                                       
REMARK 470     LEU H  73    CG   CD1  CD2                                       
REMARK 470     ARG H  74    NH1  NH2                                            
REMARK 470     ILE H  76    CG1  CG2  CD1                                       
REMARK 470     SER H  80    OG                                                  
REMARK 470     LEU H  81    CG   CD1  CD2                                       
REMARK 470     GLU H  82    CG   CD   OE1  OE2                                  
REMARK 470     TYR H  83    OH                                                  
REMARK 470     SER H  84    OG                                                  
REMARK 470     ASP H  85    CG   OD1  OD2                                       
REMARK 470     TYR H  86    OH                                                  
REMARK 470     SER H  87    OG                                                  
REMARK 470     LYS H  88    CG   CD   CE   NZ                                   
REMARK 470     CYS H  89    SG                                                  
REMARK 470     LYS H  90    CG   CD   CE   NZ                                   
REMARK 470     LYS H  91    CG   CD   CE   NZ                                   
REMARK 470     ILE H  92    CG1  CG2  CD1                                       
REMARK 470     ILE H  94    CG1  CG2  CD1                                       
REMARK 470     GLU H  95    CG   CD   OE1  OE2                                  
REMARK 470     ARG H  96    NH1  NH2                                            
REMARK 470     GLU H  98    CG   CD   OE1  OE2                                  
REMARK 470     ARG H 102    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG H 103    NH1  NH2                                            
REMARK 470     ARG H 108    NH1  NH2                                            
REMARK 470     LYS H 110    CG   CD   CE   NZ                                   
REMARK 470     TYR H 130    OH                                                  
REMARK 470     ARG H 132    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG H 136    NH1  NH2                                            
REMARK 470     LYS H 145    CG   CD   CE   NZ                                   
REMARK 470     ARG H 147    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     TYR H 151    OH                                                  
REMARK 470     ASN H 172    CG   OD1  ND2                                       
REMARK 470     VAL H 173    CG1  CG2                                            
REMARK 470     TYR H 185    OH                                                  
REMARK 470     TYR H 227    OH                                                  
REMARK 470     ARG H 237    NH1  NH2                                            
REMARK 470     TYR H 252    OH                                                  
REMARK 470     TYR H 275    OH                                                  
REMARK 470     TYR H 304    OH                                                  
REMARK 470     LEU I  28    CG   CD1  CD2                                       
REMARK 470     PRO I  29    CG   CD                                             
REMARK 470     VAL I  30    CG1  CG2                                            
REMARK 470     ASN I  32    CG   OD1  ND2                                       
REMARK 470     LYS I  33    CG   CD   CE   NZ                                   
REMARK 470     PRO I  34    CG   CD                                             
REMARK 470     LEU I  35    CG   CD1  CD2                                       
REMARK 470     TRP I  37    CH2                                                 
REMARK 470     TYR I  38    OH                                                  
REMARK 470     ARG I  45    NH1  NH2                                            
REMARK 470     THR I  55    OG1  CG2                                            
REMARK 470     THR I  56    OG1  CG2                                            
REMARK 470     ARG I  57    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP I  58    CG   OD1  OD2                                       
REMARK 470     VAL I  59    CG1  CG2                                            
REMARK 470     GLN I  60    CG   CD   OE1  NE2                                  
REMARK 470     LYS I  61    CG   CD   CE   NZ                                   
REMARK 470     LEU I  63    CG   CD1  CD2                                       
REMARK 470     CYS I  64    SG                                                  
REMARK 470     GLU I  66    CG   CD   OE1  OE2                                  
REMARK 470     PHE I  67    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     LYS I  68    CG   CD   CE   NZ                                   
REMARK 470     MET I  69    CG   SD   CE                                        
REMARK 470     LYS I  70    CG   CD   CE   NZ                                   
REMARK 470     MET I  71    CG   SD   CE                                        
REMARK 470     LYS I  72    CG   CD   CE   NZ                                   
REMARK 470     PRO I  73    CG   CD                                             
REMARK 470     ASP I  74    CG   OD1  OD2                                       
REMARK 470     ASP I  80    CG   OD1  OD2                                       
REMARK 470     ASP I  81    CG   OD1  OD2                                       
REMARK 470     ASP I  83    CG   OD1  OD2                                       
REMARK 470     MET I  84    CG   SD   CE                                        
REMARK 470     ARG I  91    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     TYR I  92    OH                                                  
REMARK 470     TYR I  94    OH                                                  
REMARK 470     ASP I 107    CG   OD1  OD2                                       
REMARK 470     LEU I 108    CG   CD1  CD2                                       
REMARK 470     ASP I 111    CG   OD1  OD2                                       
REMARK 470     ARG I 122    NH1  NH2                                            
REMARK 470     TYR I 124    OH                                                  
REMARK 470     ARG I 133    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS I 134    CG   CD   CE   NZ                                   
REMARK 470     ARG I 155    NH1  NH2                                            
REMARK 470     ARG I 166    NH1  NH2                                            
REMARK 470     ASP I 175    CG   OD1  OD2                                       
REMARK 470     ASP I 177    CG   OD1  OD2                                       
REMARK 470     GLU I 178    CG   CD   OE1  OE2                                  
REMARK 470     GLU I 179    CG   CD   OE1  OE2                                  
REMARK 470     ARG I 192    NH1  NH2                                            
REMARK 470     ARG I 194    NH1  NH2                                            
REMARK 470     TYR I 205    OH                                                  
REMARK 470     TYR I 210    OH                                                  
REMARK 470     MET I 216    CG   SD   CE                                        
REMARK 470     GLU I 217    CG   CD   OE1  OE2                                  
REMARK 470     ASN I 218    CG   OD1  ND2                                       
REMARK 470     SER I 220    OG                                                  
REMARK 470     ILE I 221    CG1  CG2  CD1                                       
REMARK 470     THR I 222    OG1  CG2                                            
REMARK 470     SER I 223    OG                                                  
REMARK 470     ILE I 224    CG1  CG2  CD1                                       
REMARK 470     ARG I 225    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     SER I 226    OG                                                  
REMARK 470     GLU I 227    CG   CD   OE1  OE2                                  
REMARK 470     LEU I 228    CG   CD1  CD2                                       
REMARK 470     ILE I 229    CG1  CG2  CD1                                       
REMARK 470     PRO I 230    CG   CD                                             
REMARK 470     TYR I 231    OH                                                  
REMARK 470     LEU I 232    CG   CD1  CD2                                       
REMARK 470     VAL I 233    CG1  CG2                                            
REMARK 470     ARG I 234    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS I 235    CG   CD   CE   NZ                                   
REMARK 470     GLN I 236    CG   CD   OE1  NE2                                  
REMARK 470     PHE I 237    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     SER I 238    OG                                                  
REMARK 470     LEU I 258    CG   CD1  CD2                                       
REMARK 470     LYS I 259    CG   CD   CE   NZ                                   
REMARK 470     SER I 260    OG                                                  
REMARK 470     TYR I 264    OH                                                  
REMARK 470     LYS I 268    CG   CD   CE   NZ                                   
REMARK 470     GLU I 269    CG   CD   OE1  OE2                                  
REMARK 470     ASN I 271    CG   OD1  ND2                                       
REMARK 470     THR I 272    OG1  CG2                                            
REMARK 470     LEU I 273    CG   CD1  CD2                                       
REMARK 470     ASN I 274    CG   OD1  ND2                                       
REMARK 470     LEU I 275    CG   CD1  CD2                                       
REMARK 470     PRO I 277    CG   CD                                             
REMARK 470     TYR I 278    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     ASP I 279    CG   OD1  OD2                                       
REMARK 470     CYS I 281    SG                                                  
REMARK 470     TRP I 282    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
REMARK 470     TRP I 282    CZ3  CH2                                            
REMARK 470     ASN I 283    CG   OD1  ND2                                       
REMARK 470     CYS I 285    SG                                                  
REMARK 470     ARG I 286    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP I 288    CG   OD1  OD2                                       
REMARK 470     ARG I 289    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     TRP I 290    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
REMARK 470     TRP I 290    CZ3  CH2                                            
REMARK 470     GLU I 291    CG   CD   OE1  OE2                                  
REMARK 470     ASP I 292    CG   OD1  OD2                                       
REMARK 470     LEU I 293    CG   CD1  CD2                                       
REMARK 470     SER I 294    OG                                                  
REMARK 470     ARG I 295    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LEU J  28    CG   CD1  CD2                                       
REMARK 470     PRO J  29    CG   CD                                             
REMARK 470     VAL J  30    CG1  CG2                                            
REMARK 470     ASN J  32    CG   OD1  ND2                                       
REMARK 470     LYS J  33    CG   CD   CE   NZ                                   
REMARK 470     PRO J  34    CG   CD                                             
REMARK 470     LEU J  35    CG   CD1  CD2                                       
REMARK 470     TRP J  37    CH2                                                 
REMARK 470     TYR J  38    OH                                                  
REMARK 470     ARG J  45    NH1  NH2                                            
REMARK 470     THR J  55    OG1  CG2                                            
REMARK 470     THR J  56    OG1  CG2                                            
REMARK 470     ARG J  57    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP J  58    CG   OD1  OD2                                       
REMARK 470     VAL J  59    CG1  CG2                                            
REMARK 470     GLN J  60    CG   CD   OE1  NE2                                  
REMARK 470     LYS J  61    CG   CD   CE   NZ                                   
REMARK 470     LEU J  63    CG   CD1  CD2                                       
REMARK 470     CYS J  64    SG                                                  
REMARK 470     GLU J  66    CG   CD   OE1  OE2                                  
REMARK 470     PHE J  67    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     LYS J  68    CG   CD   CE   NZ                                   
REMARK 470     MET J  69    CG   SD   CE                                        
REMARK 470     LYS J  70    CG   CD   CE   NZ                                   
REMARK 470     MET J  71    CG   SD   CE                                        
REMARK 470     LYS J  72    CG   CD   CE   NZ                                   
REMARK 470     PRO J  73    CG   CD                                             
REMARK 470     ASP J  74    CG   OD1  OD2                                       
REMARK 470     ASP J  80    CG   OD1  OD2                                       
REMARK 470     ASP J  81    CG   OD1  OD2                                       
REMARK 470     ASP J  83    CG   OD1  OD2                                       
REMARK 470     MET J  84    CG   SD   CE                                        
REMARK 470     ARG J  91    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     TYR J  92    OH                                                  
REMARK 470     TYR J  94    OH                                                  
REMARK 470     ASP J 107    CG   OD1  OD2                                       
REMARK 470     LEU J 108    CG   CD1  CD2                                       
REMARK 470     ASP J 111    CG   OD1  OD2                                       
REMARK 470     ARG J 122    NH1  NH2                                            
REMARK 470     TYR J 124    OH                                                  
REMARK 470     ARG J 133    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS J 134    CG   CD   CE   NZ                                   
REMARK 470     ARG J 155    NH1  NH2                                            
REMARK 470     ARG J 166    NH1  NH2                                            
REMARK 470     ASP J 175    CG   OD1  OD2                                       
REMARK 470     ASP J 177    CG   OD1  OD2                                       
REMARK 470     GLU J 178    CG   CD   OE1  OE2                                  
REMARK 470     GLU J 179    CG   CD   OE1  OE2                                  
REMARK 470     ARG J 192    NH1  NH2                                            
REMARK 470     ARG J 194    NH1  NH2                                            
REMARK 470     TYR J 205    OH                                                  
REMARK 470     TYR J 210    OH                                                  
REMARK 470     MET J 216    CG   SD   CE                                        
REMARK 470     GLU J 217    CG   CD   OE1  OE2                                  
REMARK 470     ASN J 218    CG   OD1  ND2                                       
REMARK 470     SER J 220    OG                                                  
REMARK 470     ILE J 221    CG1  CG2  CD1                                       
REMARK 470     THR J 222    OG1  CG2                                            
REMARK 470     SER J 223    OG                                                  
REMARK 470     ILE J 224    CG1  CG2  CD1                                       
REMARK 470     ARG J 225    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     SER J 226    OG                                                  
REMARK 470     GLU J 227    CG   CD   OE1  OE2                                  
REMARK 470     LEU J 228    CG   CD1  CD2                                       
REMARK 470     ILE J 229    CG1  CG2  CD1                                       
REMARK 470     PRO J 230    CG   CD                                             
REMARK 470     TYR J 231    OH                                                  
REMARK 470     LEU J 232    CG   CD1  CD2                                       
REMARK 470     VAL J 233    CG1  CG2                                            
REMARK 470     ARG J 234    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS J 235    CG   CD   CE   NZ                                   
REMARK 470     GLN J 236    CG   CD   OE1  NE2                                  
REMARK 470     PHE J 237    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     SER J 238    OG                                                  
REMARK 470     LEU J 258    CG   CD1  CD2                                       
REMARK 470     LYS J 259    CG   CD   CE   NZ                                   
REMARK 470     SER J 260    OG                                                  
REMARK 470     TYR J 264    OH                                                  
REMARK 470     LYS J 268    CG   CD   CE   NZ                                   
REMARK 470     GLU J 269    CG   CD   OE1  OE2                                  
REMARK 470     ASN J 271    CG   OD1  ND2                                       
REMARK 470     THR J 272    OG1  CG2                                            
REMARK 470     LEU J 273    CG   CD1  CD2                                       
REMARK 470     ASN J 274    CG   OD1  ND2                                       
REMARK 470     LEU J 275    CG   CD1  CD2                                       
REMARK 470     PRO J 277    CG   CD                                             
REMARK 470     TYR J 278    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     ASP J 279    CG   OD1  OD2                                       
REMARK 470     CYS J 281    SG                                                  
REMARK 470     TRP J 282    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
REMARK 470     TRP J 282    CZ3  CH2                                            
REMARK 470     ASN J 283    CG   OD1  ND2                                       
REMARK 470     CYS J 285    SG                                                  
REMARK 470     ARG J 286    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP J 288    CG   OD1  OD2                                       
REMARK 470     ARG J 289    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     TRP J 290    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
REMARK 470     TRP J 290    CZ3  CH2                                            
REMARK 470     GLU J 291    CG   CD   OE1  OE2                                  
REMARK 470     ASP J 292    CG   OD1  OD2                                       
REMARK 470     LEU J 293    CG   CD1  CD2                                       
REMARK 470     SER J 294    OG                                                  
REMARK 470     ARG J 295    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG L   6    NH1  NH2                                            
REMARK 470     TYR L   8    OH                                                  
REMARK 470     LYS L  11    CG   CD   CE   NZ                                   
REMARK 470     GLU L  14    CG   CD   OE1  OE2                                  
REMARK 470     VAL L  15    CG1  CG2                                            
REMARK 470     GLU L  16    CG   CD   OE1  OE2                                  
REMARK 470     ASP L  17    CG   OD1  OD2                                       
REMARK 470     ARG L  24    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU L  28    CB   CG   CD   OE1  OE2                             
REMARK 470     MET L  29    CG   SD   CE                                        
REMARK 470     TYR L  32    OH                                                  
REMARK 470     TYR L  38    OH                                                  
REMARK 470     LEU L  50    CD1  CD2                                            
REMARK 470     SER L  51    OG                                                  
REMARK 470     SER L  57    OG                                                  
REMARK 470     ILE L  58    CG1  CG2  CD1                                       
REMARK 470     ASN L  59    CG   OD1  ND2                                       
REMARK 470     LYS L  60    CG   CD   CE   NZ                                   
REMARK 470     LEU L  61    CG   CD1  CD2                                       
REMARK 470     ILE L  62    CG1  CG2  CD1                                       
REMARK 470     ARG L  63    NH1  NH2                                            
REMARK 470     ILE L  64    CG2  CD1                                            
REMARK 470     ARG L  66    NH1  NH2                                            
REMARK 470     GLU L  68    CG   CD   OE1  OE2                                  
REMARK 470     CYS L  69    SG                                                  
REMARK 470     VAL L  70    CG1  CG2                                            
REMARK 470     VAL L  71    CG1  CG2                                            
REMARK 470     VAL L  72    CG1  CG2                                            
REMARK 470     ILE L  73    CG1  CG2  CD1                                       
REMARK 470     ARG L  74    NH1  NH2                                            
REMARK 470     LYS L  77    CG   CD   CE   NZ                                   
REMARK 470     GLU L  78    CG   CD   OE1  OE2                                  
REMARK 470     LYS L  79    CD   CE   NZ                                        
REMARK 470     TYR L  81    OH                                                  
REMARK 470     ASP L  83    CG   OD1  OD2                                       
REMARK 470     ARG L  87    NH1  NH2                                            
REMARK 470     ARG L  88    NH1  NH2                                            
REMARK 470     GLU L  92    CG   CD   OE1  OE2                                  
REMARK 470     GLU L  93    CG   CD   OE1  OE2                                  
REMARK 470     ILE L  95    CG1  CG2  CD1                                       
REMARK 470     CYS L  97    SG                                                  
REMARK 470     GLU L  98    CG   CD   OE1  OE2                                  
REMARK 470     ASP L  99    CG   OD1  OD2                                       
REMARK 470     THR L 102    OG1  CG2                                            
REMARK 470     SER L 104    OG                                                  
REMARK 470     THR L 106    OG1  CG2                                            
REMARK 470     VAL L 107    CG1  CG2                                            
REMARK 470     TYR L 108    OH                                                  
REMARK 470     SER L 109    OG                                                  
REMARK 470     ILE L 110    CG1  CG2  CD1                                       
REMARK 470     ARG L 112    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     HIS L 113    CG   ND1  CD2  CE1  NE2                             
REMARK 470     VAL L 114    CG1  CG2                                            
REMARK 470     GLU L 116    CG   CD   OE1  OE2                                  
REMARK 470     VAL L 117    CG1  CG2                                            
REMARK 470     LEU L 118    CG   CD1  CD2                                       
REMARK 470     GLU L 119    CG   CD   OE1  OE2                                  
REMARK 470     TYR L 120    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     THR L 121    OG1  CG2                                            
REMARK 470     LYS L 122    CG   CD   CE   NZ                                   
REMARK 470     ASP L 123    CG   OD1  OD2                                       
REMARK 470     GLU L 124    CG   CD   OE1  OE2                                  
REMARK 470     GLN L 125    CG   CD   OE1  NE2                                  
REMARK 470     GLU L 127    CG   CD   OE1  OE2                                  
REMARK 470     SER L 128    OG                                                  
REMARK 470     GLN L 131    CG   CD   OE1  NE2                                  
REMARK 470     ARG L 132    NH1  NH2                                            
REMARK 470     THR L 133    OG1  CG2                                            
REMARK 470     TRP L 135    CH2                                                 
REMARK 470     VAL L 136    CG1  CG2                                            
REMARK 470     ASP L 138    CG   OD1  OD2                                       
REMARK 470     ASP L 139    CG   OD1  OD2                                       
REMARK 470     LYS L 140    CG   CD   CE   NZ                                   
REMARK 470     TYR L 141    OH                                                  
REMARK 470     LYS L 142    CG   CD   CE   NZ                                   
REMARK 470     ARG L 143    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     PRO L 144    CG   CD                                             
REMARK 470     TYR L 146    OH                                                  
REMARK 470     TYR L 149    OH                                                  
REMARK 470     ASP L 150    CG   OD1  OD2                                       
REMARK 470     LYS L 153    CG   CD   CE   NZ                                   
REMARK 470     HIS L 154    CG   ND1  CD2  CE1  NE2                             
REMARK 470     VAL L 156    CG1  CG2                                            
REMARK 470     SER L 157    OG                                                  
REMARK 470     ASP L 158    CG   OD1  OD2                                       
REMARK 470     PRO L 159    CG   CD                                             
REMARK 470     SER L 160    OG                                                  
REMARK 470     ILE L 161    CG1  CG2  CD1                                       
REMARK 470     LEU L 162    CG   CD1  CD2                                       
REMARK 470     ASP L 163    CG   OD1  OD2                                       
REMARK 470     SER L 164    OG                                                  
REMARK 470     LEU L 165    CG   CD1  CD2                                       
REMARK 470     ASP L 166    CG   OD1  OD2                                       
REMARK 470     LEU L 167    CG   CD1  CD2                                       
REMARK 470     ASN L 168    CG   OD1  ND2                                       
REMARK 470     GLU L 169    CG   CD   OE1  OE2                                  
REMARK 470     ASP L 170    CG   OD1  OD2                                       
REMARK 470     GLU L 171    CG   CD   OE1  OE2                                  
REMARK 470     ARG L 172    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU L 173    CG   CD   OE1  OE2                                  
REMARK 470     VAL L 174    CG1  CG2                                            
REMARK 470     LEU L 175    CG   CD1  CD2                                       
REMARK 470     ILE L 176    CG1  CG2  CD1                                       
REMARK 470     ASN L 177    CG   OD1  ND2                                       
REMARK 470     ASN L 178    CG   OD1  ND2                                       
REMARK 470     ILE L 179    CG1  CG2  CD1                                       
REMARK 470     ASN L 180    CG   OD1  ND2                                       
REMARK 470     ARG L 181    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG L 182    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LEU L 183    CG   CD1  CD2                                       
REMARK 470     THR L 184    OG1  CG2                                            
REMARK 470     PRO L 185    CG   CD                                             
REMARK 470     GLN L 186    CG   CD   OE1  NE2                                  
REMARK 470     VAL L 188    CG1  CG2                                            
REMARK 470     LYS L 189    CG   CD   CE   NZ                                   
REMARK 470     ILE L 190    CG1  CG2  CD1                                       
REMARK 470     ARG L 191    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP L 193    CG   OD1  OD2                                       
REMARK 470     ILE L 194    CG1  CG2  CD1                                       
REMARK 470     GLU L 195    CG   CD   OE1  OE2                                  
REMARK 470     VAL L 196    CG1  CG2                                            
REMARK 470     CYS L 198    SG                                                  
REMARK 470     TYR L 199    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     TYR L 201    OH                                                  
REMARK 470     GLU L 202    CG   CD   OE1  OE2                                  
REMARK 470     ILE L 204    CG1  CG2  CD1                                       
REMARK 470     ASP L 205    CG   OD1  OD2                                       
REMARK 470     VAL L 207    CG1  CG2                                            
REMARK 470     LYS L 208    CG   CD   CE   NZ                                   
REMARK 470     GLU L 209    CG   CD   OE1  OE2                                  
REMARK 470     LEU L 211    CG   CD1  CD2                                       
REMARK 470     ARG L 212    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LEU L 215    CG   CD1  CD2                                       
REMARK 470     ASN L 216    CG   OD1  ND2                                       
REMARK 470     CYS L 217    SG                                                  
REMARK 470     SER L 218    OG                                                  
REMARK 470     THR L 219    OG1  CG2                                            
REMARK 470     GLU L 220    CG   CD   OE1  OE2                                  
REMARK 470     ASN L 221    CG   OD1  ND2                                       
REMARK 470     MET L 222    CG   SD   CE                                        
REMARK 470     PRO L 223    CG   CD                                             
REMARK 470     ILE L 224    CG1  CG2  CD1                                       
REMARK 470     LYS L 225    CG   CD   CE   NZ                                   
REMARK 470     ILE L 226    CG1  CG2  CD1                                       
REMARK 470     ASN L 227    CG   OD1  ND2                                       
REMARK 470     LEU L 228    CG   CD1  CD2                                       
REMARK 470     ILE L 229    CG1  CG2  CD1                                       
REMARK 470     PRO L 231    CG   CD                                             
REMARK 470     PRO L 232    CG   CD                                             
REMARK 470     ARG L 233    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     TYR L 234    OH                                                  
REMARK 470     VAL L 235    CG1  CG2                                            
REMARK 470     MET L 236    CG   SD   CE                                        
REMARK 470     THR L 237    OG1  CG2                                            
REMARK 470     THR L 238    OG1  CG2                                            
REMARK 470     THR L 239    OG1  CG2                                            
REMARK 470     THR L 240    OG1  CG2                                            
REMARK 470     LEU L 241    CG   CD1  CD2                                       
REMARK 470     GLU L 242    CG   CD   OE1  OE2                                  
REMARK 470     ARG L 243    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     THR L 244    OG1  CG2                                            
REMARK 470     GLU L 245    CG   CD   OE1  OE2                                  
REMARK 470     LEU L 247    CG   CD1  CD2                                       
REMARK 470     SER L 248    OG                                                  
REMARK 470     VAL L 249    CG1  CG2                                            
REMARK 470     LEU L 250    CG   CD1  CD2                                       
REMARK 470     SER L 251    OG                                                  
REMARK 470     GLN L 252    CG   CD   OE1  NE2                                  
REMARK 470     MET L 254    CG   SD   CE                                        
REMARK 470     VAL L 256    CG1  CG2                                            
REMARK 470     ILE L 257    CG1  CG2  CD1                                       
REMARK 470     LYS L 258    CG   CD   CE   NZ                                   
REMARK 470     GLU L 259    CG   CD   OE1  OE2                                  
REMARK 470     LYS L 260    CG   CD   CE   NZ                                   
REMARK 470     ILE L 261    CG1  CG2  CD1                                       
REMARK 470     GLU L 262    CG   CD   OE1  OE2                                  
REMARK 470     GLU L 263    CG   CD   OE1  OE2                                  
REMARK 470     LYS L 264    CG   CD   CE   NZ                                   
REMARK 470     ARG L 265    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     VAL L 267    CG1  CG2                                            
REMARK 470     PHE L 268    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ASN L 269    CG   OD1  ND2                                       
REMARK 470     VAL L 270    CG1  CG2                                            
REMARK 470     GLN L 271    CG   CD   OE1  NE2                                  
REMARK 470     MET L 272    CG   SD   CE                                        
REMARK 470     GLU L 273    CG   CD   OE1  OE2                                  
REMARK 470     PRO L 274    CG   CD                                             
REMARK 470     LYS L 275    CG   CD   CE   NZ                                   
REMARK 470     VAL L 276    CG1  CG2                                            
REMARK 470     VAL L 277    CG1  CG2                                            
REMARK 470     LEU S  20    CG   CD1  CD2                                       
REMARK 470     THR S  21    OG1  CG2                                            
REMARK 470     THR S  22    OG1  CG2                                            
REMARK 470     LEU S  23    CG   CD1  CD2                                       
REMARK 470     ASP S  24    CG   OD1  OD2                                       
REMARK 470     VAL S  25    CG1  CG2                                            
REMARK 470     THR S  26    OG1  CG2                                            
REMARK 470     LYS S  27    CG   CD   CE   NZ                                   
REMARK 470     LEU S  28    CG   CD1  CD2                                       
REMARK 470     THR S  29    OG1  CG2                                            
REMARK 470     PRO S  30    CG   CD                                             
REMARK 470     LEU S  31    CG   CD1  CD2                                       
REMARK 470     SER S  32    OG                                                  
REMARK 470     HIS S  33    CG   ND1  CD2  CE1  NE2                             
REMARK 470     GLU S  34    CG   CD   OE1  OE2                                  
REMARK 470     VAL S  35    CG1  CG2                                            
REMARK 470     ILE S  36    CG1  CG2  CD1                                       
REMARK 470     SER S  37    OG                                                  
REMARK 470     ARG S  38    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLN S  39    CG   CD   OE1  NE2                                  
REMARK 470     THR S  41    OG1  CG2                                            
REMARK 470     ILE S  42    CG1  CG2  CD1                                       
REMARK 470     ASN S  43    CG   OD1  ND2                                       
REMARK 470     ILE S  44    CG1  CG2  CD1                                       
REMARK 470     THR S  46    OG1  CG2                                            
REMARK 470     ILE S  47    CG1  CG2  CD1                                       
REMARK 470     HIS S  49    CG   ND1  CD2  CE1  NE2                             
REMARK 470     VAL S  50    CG1  CG2                                            
REMARK 470     HIS S  52    CG   ND1  CD2  CE1  NE2                             
REMARK 470     LYS S  54    CG   CD   CE   NZ                                   
REMARK 470     SER S  55    OG                                                  
REMARK 470     THR S  56    OG1  CG2                                            
REMARK 470     VAL S  57    CG1  CG2                                            
REMARK 470     VAL S  58    CG1  CG2                                            
REMARK 470     LYS S  59    CG   CD   CE   NZ                                   
REMARK 470     ILE S  61    CG1  CG2  CD1                                       
REMARK 470     SER S  62    OG                                                  
REMARK 470     VAL S  64    CG1  CG2                                            
REMARK 470     HIS S  65    CG   ND1  CD2  CE1  NE2                             
REMARK 470     THR S  66    OG1  CG2                                            
REMARK 470     VAL S  67    CG1  CG2                                            
REMARK 470     ARG S  68    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     PHE S  69    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     LYS S  70    CG   CD   CE   NZ                                   
REMARK 470     ASN S  71    CG   OD1  ND2                                       
REMARK 470     GLU S  72    CG   CD   OE1  OE2                                  
REMARK 470     LEU S  73    CG   CD1  CD2                                       
REMARK 470     GLU S  74    CG   CD   OE1  OE2                                  
REMARK 470     ARG S  75    NH1  NH2                                            
REMARK 470     ASN S  76    CG   OD1  ND2                                       
REMARK 470     ILE S  77    CG1  CG2  CD1                                       
REMARK 470     THR S  78    OG1  CG2                                            
REMARK 470     ILE S  79    CG1  CG2  CD1                                       
REMARK 470     LYS S  80    CG   CD   CE   NZ                                   
REMARK 470     LEU S  81    CG   CD1  CD2                                       
REMARK 470     TYR S  83    OH                                                  
REMARK 470     ASN S  85    CG   OD1  ND2                                       
REMARK 470     LYS S  87    CG   CD   CE   NZ                                   
REMARK 470     ILE S  88    CG1  CG2  CD1                                       
REMARK 470     TYR S  89    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     LYS S  90    CG   CD   CE   NZ                                   
REMARK 470     LEU S  91    CG   CD1  CD2                                       
REMARK 470     ASN S 123    CG   OD1  ND2                                       
REMARK 470     PHE S 124    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     LYS S 125    CG   CD   CE   NZ                                   
REMARK 470     LEU S 126    CG   CD1  CD2                                       
REMARK 470     VAL S 127    CG1  CG2                                            
REMARK 470     ARG S 128    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     HIS S 129    CG   ND1  CD2  CE1  NE2                             
REMARK 470     VAL S 130    CG1  CG2                                            
REMARK 470     SER S 131    OG                                                  
REMARK 470     PHE S 132    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     VAL S 133    CG1  CG2                                            
REMARK 470     ASP S 134    CG   OD1  OD2                                       
REMARK 470     CYS S 135    SG                                                  
REMARK 470     PRO S 136    CG   CD                                             
REMARK 470     HIS S 138    CG   ND1  CD2  CE1  NE2                             
REMARK 470     ASP S 139    CG   OD1  OD2                                       
REMARK 470     ILE S 140    CG1  CG2  CD1                                       
REMARK 470     LEU S 141    CG   CD1  CD2                                       
REMARK 470     MET S 142    CG   SD   CE                                        
REMARK 470     THR S 144    OG1  CG2                                            
REMARK 470     MET S 145    CG   SD   CE                                        
REMARK 470     LEU S 146    CG   CD1  CD2                                       
REMARK 470     ASN S 147    CG   OD1  ND2                                       
REMARK 470     VAL S 151    CG1  CG2                                            
REMARK 470     MET S 152    CG   SD   CE                                        
REMARK 470     ASP S 153    CG   OD1  OD2                                       
REMARK 470     LEU S 156    CG   CD1  CD2                                       
REMARK 470     LEU S 157    CG   CD1  CD2                                       
REMARK 470     LEU S 158    CG   CD1  CD2                                       
REMARK 470     ILE S 159    CG1  CG2  CD1                                       
REMARK 470     ASN S 162    CG   OD1  ND2                                       
REMARK 470     GLU S 163    CG   CD   OE1  OE2                                  
REMARK 470     SER S 164    OG                                                  
REMARK 470     CYS S 165    SG                                                  
REMARK 470     PRO S 166    CG   CD                                             
REMARK 470     GLN S 167    CG   CD   OE1  NE2                                  
REMARK 470     PRO S 168    CG   CD                                             
REMARK 470     GLN S 169    CG   CD   OE1  NE2                                  
REMARK 470     THR S 170    OG1  CG2                                            
REMARK 470     SER S 171    OG                                                  
REMARK 470     GLU S 172    CG   CD   OE1  OE2                                  
REMARK 470     HIS S 173    CG   ND1  CD2  CE1  NE2                             
REMARK 470     LEU S 174    CG   CD1  CD2                                       
REMARK 470     ILE S 177    CG1  CG2  CD1                                       
REMARK 470     GLU S 178    CG   CD   OE1  OE2                                  
REMARK 470     ILE S 179    CG1  CG2  CD1                                       
REMARK 470     HIS S 184    CG   ND1  CD2  CE1  NE2                             
REMARK 470     ILE S 185    CG1  CG2  CD1                                       
REMARK 470     LEU S 186    CG   CD1  CD2                                       
REMARK 470     ILE S 187    CG1  CG2  CD1                                       
REMARK 470     LEU S 188    CG   CD1  CD2                                       
REMARK 470     GLN S 189    CG   CD   OE1  NE2                                  
REMARK 470     ASN S 190    CG   OD1  ND2                                       
REMARK 470     LYS S 191    CG   CD   CE   NZ                                   
REMARK 470     ILE S 192    CG1  CG2  CD1                                       
REMARK 470     ASP S 193    CG   OD1  OD2                                       
REMARK 470     LEU S 194    CG   CD1  CD2                                       
REMARK 470     VAL S 195    CG1  CG2                                            
REMARK 470     LYS S 196    CG   CD   CE   NZ                                   
REMARK 470     GLU S 197    CG   CD   OE1  OE2                                  
REMARK 470     SER S 198    OG                                                  
REMARK 470     GLN S 199    CG   CD   OE1  NE2                                  
REMARK 470     LYS S 201    CG   CD   CE   NZ                                   
REMARK 470     GLU S 202    CG   CD   OE1  OE2                                  
REMARK 470     GLN S 203    CG   CD   OE1  NE2                                  
REMARK 470     TYR S 204    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     GLU S 205    CG   CD   OE1  OE2                                  
REMARK 470     GLN S 206    CG   CD   OE1  NE2                                  
REMARK 470     ILE S 207    CG1  CG2  CD1                                       
REMARK 470     LEU S 208    CG   CD1  CD2                                       
REMARK 470     PHE S 210    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     VAL S 211    CG1  CG2                                            
REMARK 470     GLN S 212    CG   CD   OE1  NE2                                  
REMARK 470     THR S 214    OG1  CG2                                            
REMARK 470     VAL S 215    CG1  CG2                                            
REMARK 470     GLU S 217    CG   CD   OE1  OE2                                  
REMARK 470     PRO S 220    CG   CD                                             
REMARK 470     ILE S 221    CG1  CG2  CD1                                       
REMARK 470     ILE S 222    CG1  CG2  CD1                                       
REMARK 470     PRO S 223    CG   CD                                             
REMARK 470     LEU S 228    CG   CD1  CD2                                       
REMARK 470     LYS S 229    CG   CD   CE   NZ                                   
REMARK 470     TYR S 230    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     ASN S 231    CG   OD1  ND2                                       
REMARK 470     ILE S 232    CG1  CG2  CD1                                       
REMARK 470     GLU S 233    CG   CD   OE1  OE2                                  
REMARK 470     VAL S 234    CG1  CG2                                            
REMARK 470     VAL S 235    CG1  CG2                                            
REMARK 470     CYS S 236    SG                                                  
REMARK 470     GLU S 237    CG   CD   OE1  OE2                                  
REMARK 470     TYR S 238    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     ILE S 239    CG1  CG2  CD1                                       
REMARK 470     VAL S 240    CG1  CG2                                            
REMARK 470     LYS S 241    CG   CD   CE   NZ                                   
REMARK 470     LYS S 242    CG   CD   CE   NZ                                   
REMARK 470     ILE S 243    CG1  CG2  CD1                                       
REMARK 470     PRO S 244    CG   CD                                             
REMARK 470     VAL S 245    CG1  CG2                                            
REMARK 470     PRO S 246    CG   CD                                             
REMARK 470     PRO S 247    CG   CD                                             
REMARK 470     ARG S 248    NH1  NH2                                            
REMARK 470     ASP S 249    CG   OD1  OD2                                       
REMARK 470     THR S 251    OG1  CG2                                            
REMARK 470     SER S 252    OG                                                  
REMARK 470     GLU S 253    CG   CD   OE1  OE2                                  
REMARK 470     PRO S 254    CG   CD                                             
REMARK 470     ARG S 255    NH1  NH2                                            
REMARK 470     LEU S 256    CG   CD1  CD2                                       
REMARK 470     ILE S 257    CG1  CG2  CD1                                       
REMARK 470     VAL S 258    CG1  CG2                                            
REMARK 470     ILE S 259    CG1  CG2  CD1                                       
REMARK 470     ARG S 260    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     SER S 261    OG                                                  
REMARK 470     ASP S 263    CG   OD1  OD2                                       
REMARK 470     VAL S 264    CG1  CG2                                            
REMARK 470     ASN S 265    CG   OD1  ND2                                       
REMARK 470     LYS S 266    CG   CD   CE   NZ                                   
REMARK 470     PRO S 267    CG   CD                                             
REMARK 470     CYS S 269    SG                                                  
REMARK 470     GLU S 270    CG   CD   OE1  OE2                                  
REMARK 470     VAL S 271    CG1  CG2                                            
REMARK 470     ASP S 272    CG   OD1  OD2                                       
REMARK 470     ASP S 273    CG   OD1  OD2                                       
REMARK 470     LEU S 274    CG   CD1  CD2                                       
REMARK 470     LYS S 275    CG   CD   CE   NZ                                   
REMARK 470     VAL S 278    CG1  CG2                                            
REMARK 470     SER S 282    OG                                                  
REMARK 470     ILE S 283    CG1  CG2  CD1                                       
REMARK 470     LEU S 284    CG   CD1  CD2                                       
REMARK 470     LYS S 285    CG   CD   CE   NZ                                   
REMARK 470     VAL S 287    CG1  CG2                                            
REMARK 470     LEU S 288    CG   CD1  CD2                                       
REMARK 470     LYS S 289    CG   CD   CE   NZ                                   
REMARK 470     VAL S 290    CG1  CG2                                            
REMARK 470     GLN S 292    CG   CD   OE1  NE2                                  
REMARK 470     GLU S 293    CG   CD   OE1  OE2                                  
REMARK 470     ILE S 294    CG1  CG2  CD1                                       
REMARK 470     GLU S 295    CG   CD   OE1  OE2                                  
REMARK 470     VAL S 296    CG1  CG2                                            
REMARK 470     ARG S 297    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     PRO S 298    CG   CD                                             
REMARK 470     ILE S 300    CG1  CG2  CD1                                       
REMARK 470     VAL S 301    CG1  CG2                                            
REMARK 470     SER S 302    OG                                                  
REMARK 470     LYS S 303    CG   CD   CE   NZ                                   
REMARK 470     ASP S 304    CG   OD1  OD2                                       
REMARK 470     SER S 305    OG                                                  
REMARK 470     GLU S 306    CG   CD   OE1  OE2                                  
REMARK 470     LYS S 308    CG   CD   CE   NZ                                   
REMARK 470     LEU S 309    CG   CD1  CD2                                       
REMARK 470     MET S 310    CG   SD   CE                                        
REMARK 470     CYS S 311    SG                                                  
REMARK 470     LYS S 312    CG   CD   CE   NZ                                   
REMARK 470     PRO S 313    CG   CD                                             
REMARK 470     ILE S 314    CG1  CG2  CD1                                       
REMARK 470     SER S 316    OG                                                  
REMARK 470     LYS S 317    CG   CD   CE   NZ                                   
REMARK 470     ILE S 318    CG1  CG2  CD1                                       
REMARK 470     VAL S 319    CG1  CG2                                            
REMARK 470     SER S 320    OG                                                  
REMARK 470     LEU S 321    CG   CD1  CD2                                       
REMARK 470     PHE S 322    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     GLU S 324    CG   CD   OE1  OE2                                  
REMARK 470     HIS S 325    CG   ND1  CD2  CE1  NE2                             
REMARK 470     ASN S 326    CG   OD1  ND2                                       
REMARK 470     ASP S 327    CG   OD1  OD2                                       
REMARK 470     LEU S 328    CG   CD1  CD2                                       
REMARK 470     GLN S 329    CG   CD   OE1  NE2                                  
REMARK 470     TYR S 330    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     PRO S 333    CG   CD                                             
REMARK 470     LEU S 336    CG   CD1  CD2                                       
REMARK 470     ILE S 337    CG1  CG2  CD1                                       
REMARK 470     VAL S 339    CG1  CG2                                            
REMARK 470     THR S 341    OG1  CG2                                            
REMARK 470     LYS S 342    CG   CD   CE   NZ                                   
REMARK 470     ILE S 343    CG1  CG2  CD1                                       
REMARK 470     ASP S 344    CG   OD1  OD2                                       
REMARK 470     PRO S 345    CG   CD                                             
REMARK 470     THR S 346    OG1  CG2                                            
REMARK 470     LEU S 347    CG   CD1  CD2                                       
REMARK 470     CYS S 348    SG                                                  
REMARK 470     ARG S 349    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP S 351    CG   OD1  OD2                                       
REMARK 470     ARG S 352    NH1  NH2                                            
REMARK 470     MET S 353    CG   SD   CE                                        
REMARK 470     VAL S 354    CG1  CG2                                            
REMARK 470     GLN S 356    CG   CD   OE1  NE2                                  
REMARK 470     VAL S 357    CG1  CG2                                            
REMARK 470     LEU S 358    CG   CD1  CD2                                       
REMARK 470     VAL S 361    CG1  CG2                                            
REMARK 470     LEU S 364    CG   CD1  CD2                                       
REMARK 470     PRO S 365    CG   CD                                             
REMARK 470     GLU S 366    CG   CD   OE1  OE2                                  
REMARK 470     ILE S 367    CG1  CG2  CD1                                       
REMARK 470     THR S 369    OG1  CG2                                            
REMARK 470     GLU S 370    CG   CD   OE1  OE2                                  
REMARK 470     LEU S 371    CG   CD1  CD2                                       
REMARK 470     GLU S 372    CG   CD   OE1  OE2                                  
REMARK 470     ILE S 373    CG1  CG2  CD1                                       
REMARK 470     SER S 374    OG                                                  
REMARK 470     TYR S 375    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     PHE S 376    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     LEU S 377    CG   CD1  CD2                                       
REMARK 470     LEU S 378    CG   CD1  CD2                                       
REMARK 470     ARG S 379    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG S 380    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LEU S 381    CG   CD1  CD2                                       
REMARK 470     LEU S 382    CG   CD1  CD2                                       
REMARK 470     VAL S 384    CG1  CG2                                            
REMARK 470     ARG S 385    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     THR S 386    OG1  CG2                                            
REMARK 470     GLU S 387    CG   CD   OE1  OE2                                  
REMARK 470     ASP S 389    CG   OD1  OD2                                       
REMARK 470     LYS S 390    CG   CD   CE   NZ                                   
REMARK 470     LYS S 391    CG   CD   CE   NZ                                   
REMARK 470     LYS S 394    CG   CD   CE   NZ                                   
REMARK 470     VAL S 395    CG1  CG2                                            
REMARK 470     GLN S 396    CG   CD   OE1  NE2                                  
REMARK 470     LYS S 397    CG   CD   CE   NZ                                   
REMARK 470     LEU S 398    CG   CD1  CD2                                       
REMARK 470     SER S 399    OG                                                  
REMARK 470     LYS S 400    CG   CD   CE   NZ                                   
REMARK 470     ASN S 401    CG   OD1  ND2                                       
REMARK 470     GLU S 402    CG   CD   OE1  OE2                                  
REMARK 470     VAL S 403    CG1  CG2                                            
REMARK 470     LEU S 404    CG   CD1  CD2                                       
REMARK 470     VAL S 406    CG1  CG2                                            
REMARK 470     ASN S 407    CG   OD1  ND2                                       
REMARK 470     ILE S 408    CG1  CG2  CD1                                       
REMARK 470     SER S 410    OG                                                  
REMARK 470     LEU S 411    CG   CD1  CD2                                       
REMARK 470     SER S 412    OG                                                  
REMARK 470     THR S 413    OG1  CG2                                            
REMARK 470     ARG S 416    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     VAL S 417    CG1  CG2                                            
REMARK 470     SER S 418    OG                                                  
REMARK 470     VAL S 420    CG1  CG2                                            
REMARK 470     LYS S 421    CG   CD   CE   NZ                                   
REMARK 470     ASP S 423    CG   OD1  OD2                                       
REMARK 470     LEU S 424    CG   CD1  CD2                                       
REMARK 470     LYS S 426    CG   CD   CE   NZ                                   
REMARK 470     ILE S 427    CG1  CG2  CD1                                       
REMARK 470     VAL S 428    CG1  CG2                                            
REMARK 470     LEU S 429    CG   CD1  CD2                                       
REMARK 470     THR S 430    OG1  CG2                                            
REMARK 470     ASN S 431    CG   OD1  ND2                                       
REMARK 470     PRO S 432    CG   CD                                             
REMARK 470     VAL S 433    CG1  CG2                                            
REMARK 470     CYS S 434    SG                                                  
REMARK 470     THR S 435    OG1  CG2                                            
REMARK 470     GLU S 436    CG   CD   OE1  OE2                                  
REMARK 470     VAL S 437    CG1  CG2                                            
REMARK 470     GLU S 439    CG   CD   OE1  OE2                                  
REMARK 470     LYS S 440    CG   CD   CE   NZ                                   
REMARK 470     ILE S 441    CG1  CG2  CD1                                       
REMARK 470     LEU S 443    CG   CD1  CD2                                       
REMARK 470     SER S 444    OG                                                  
REMARK 470     ARG S 445    NH1  NH2                                            
REMARK 470     ARG S 446    NH1  NH2                                            
REMARK 470     VAL S 447    CG1  CG2                                            
REMARK 470     GLU S 448    CG   CD   OE1  OE2                                  
REMARK 470     LYS S 449    CG   CD   CE   NZ                                   
REMARK 470     TRP S 451    CH2                                                 
REMARK 470     ARG S 452    NH1  NH2                                            
REMARK 470     LEU S 453    CG   CD1  CD2                                       
REMARK 470     ILE S 454    CG1  CG2  CD1                                       
REMARK 470     TRP S 456    CH2                                                 
REMARK 470     GLN S 458    CG   CD   OE1  NE2                                  
REMARK 470     ILE S 459    CG1  CG2  CD1                                       
REMARK 470     ARG S 460    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG S 461    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     VAL S 463    CG1  CG2                                            
REMARK 470     THR S 464    OG1  CG2                                            
REMARK 470     ILE S 465    CG1  CG2  CD1                                       
REMARK 470     LYS S 466    CG   CD   CE   NZ                                   
REMARK 470     PRO S 467    CG   CD                                             
REMARK 470     THR S 468    OG1  CG2                                            
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS                                      
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,2(A3,1X,A1,I4,A1,1X,A4,3X),1X,F6.3)               
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   RES CSSEQI ATM2   DEVIATION                     
REMARK 500    TRP A  97   CE2   TRP A  97   CD2     0.074                       
REMARK 500    TRP A 111   CE2   TRP A 111   CD2     0.075                       
REMARK 500    TRP A 317   CE2   TRP A 317   CD2     0.074                       
REMARK 500    TRP A 397   CE2   TRP A 397   CD2     0.073                       
REMARK 500    TRP B  97   CE2   TRP B  97   CD2     0.074                       
REMARK 500    TRP B 111   CE2   TRP B 111   CD2     0.073                       
REMARK 500    TRP B 317   CE2   TRP B 317   CD2     0.074                       
REMARK 500    TRP B 397   CE2   TRP B 397   CD2     0.074                       
REMARK 500    TRP B 628   CE2   TRP B 628   CD2     0.075                       
REMARK 500    TRP C  51   CE2   TRP C  51   CD2     0.074                       
REMARK 500    TRP D  51   CE2   TRP D  51   CD2     0.074                       
REMARK 500    TRP E 350   CE2   TRP E 350   CD2     0.073                       
REMARK 500    TRP E 366   CE2   TRP E 366   CD2     0.074                       
REMARK 500    TRP E 476   CE2   TRP E 476   CD2     0.073                       
REMARK 500    TRP F 350   CE2   TRP F 350   CD2     0.074                       
REMARK 500    TRP F 366   CE2   TRP F 366   CD2     0.073                       
REMARK 500    TRP I  37   CE2   TRP I  37   CD2     0.074                       
REMARK 500    TRP J  37   CE2   TRP J  37   CD2     0.074                       
REMARK 500    TRP L 135   CE2   TRP L 135   CD2     0.073                       
REMARK 500    TRP S 451   CE2   TRP S 451   CD2     0.074                       
REMARK 500    TRP S 456   CE2   TRP S 456   CD2     0.075                       
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500    TRP A  97   CD2 -  CE3 -  CZ3 ANGL. DEV. =  10.6 DEGREES          
REMARK 500    TRP A 111   CD2 -  CE3 -  CZ3 ANGL. DEV. =  10.5 DEGREES          
REMARK 500    LEU A 283   CA  -  CB  -  CG  ANGL. DEV. =  18.4 DEGREES          
REMARK 500    TRP A 317   CD2 -  CE3 -  CZ3 ANGL. DEV. =  10.7 DEGREES          
REMARK 500    TRP A 397   CD2 -  CE3 -  CZ3 ANGL. DEV. =  10.6 DEGREES          
REMARK 500    TRP B  97   CD2 -  CE3 -  CZ3 ANGL. DEV. =  10.5 DEGREES          
REMARK 500    TRP B 111   CD2 -  CE3 -  CZ3 ANGL. DEV. =  10.5 DEGREES          
REMARK 500    LEU B 283   CA  -  CB  -  CG  ANGL. DEV. =  17.9 DEGREES          
REMARK 500    TRP B 317   CD2 -  CE3 -  CZ3 ANGL. DEV. =  10.6 DEGREES          
REMARK 500    TRP B 397   CD2 -  CE3 -  CZ3 ANGL. DEV. =  10.6 DEGREES          
REMARK 500    TRP B 628   CD2 -  CE3 -  CZ3 ANGL. DEV. =  10.5 DEGREES          
REMARK 500    TRP C  51   CD2 -  CE3 -  CZ3 ANGL. DEV. =  10.5 DEGREES          
REMARK 500    TRP D  51   CD2 -  CE3 -  CZ3 ANGL. DEV. =  10.6 DEGREES          
REMARK 500    TRP E 350   CD2 -  CE3 -  CZ3 ANGL. DEV. =  10.5 DEGREES          
REMARK 500    TRP E 366   CD2 -  CE3 -  CZ3 ANGL. DEV. =  10.6 DEGREES          
REMARK 500    TRP E 476   CD2 -  CE3 -  CZ3 ANGL. DEV. =  10.6 DEGREES          
REMARK 500    TRP F 350   CD2 -  CE3 -  CZ3 ANGL. DEV. =  10.6 DEGREES          
REMARK 500    TRP F 366   CD2 -  CE3 -  CZ3 ANGL. DEV. =  10.5 DEGREES          
REMARK 500    TRP F 476   CD2 -  CE3 -  CZ3 ANGL. DEV. =  10.6 DEGREES          
REMARK 500    LEU G 114   CA  -  CB  -  CG  ANGL. DEV. =  17.6 DEGREES          
REMARK 500    ASP G 180   CB  -  CG  -  OD1 ANGL. DEV. =   5.6 DEGREES          
REMARK 500    LEU H 114   CA  -  CB  -  CG  ANGL. DEV. =  17.6 DEGREES          
REMARK 500    ASP H 180   CB  -  CG  -  OD1 ANGL. DEV. =   5.5 DEGREES          
REMARK 500    TRP I  37   CD2 -  CE3 -  CZ3 ANGL. DEV. =  10.5 DEGREES          
REMARK 500    TRP J  37   CD2 -  CE3 -  CZ3 ANGL. DEV. =  10.5 DEGREES          
REMARK 500    TRP L 135   CD2 -  CE3 -  CZ3 ANGL. DEV. =  10.6 DEGREES          
REMARK 500    TRP S 451   CD2 -  CE3 -  CZ3 ANGL. DEV. =  10.5 DEGREES          
REMARK 500    TRP S 456   CD2 -  CE3 -  CZ3 ANGL. DEV. =  10.5 DEGREES          
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    PRO A  58       39.02    -93.39                                   
REMARK 500    ASN A  72       -4.73     67.81                                   
REMARK 500    ASP A 147       66.57     60.64                                   
REMARK 500    CYS A 252     -169.66   -124.34                                   
REMARK 500    SER A 338     -168.26   -100.74                                   
REMARK 500    SER A 433       70.95     61.09                                   
REMARK 500    GLN A 434       64.23     64.75                                   
REMARK 500    SER A 450     -167.89   -160.93                                   
REMARK 500    PRO B  58       37.69    -95.38                                   
REMARK 500    ASN B  72       17.31     57.82                                   
REMARK 500    CYS B  96      -60.99   -102.49                                   
REMARK 500    ASN B 158       31.21   -140.94                                   
REMARK 500    PRO B 254        1.21    -68.52                                   
REMARK 500    SER B 301       -1.98   -144.64                                   
REMARK 500    SER B 610       50.49   -143.10                                   
REMARK 500    PRO C  28     -166.89    -79.85                                   
REMARK 500    SER C 284       53.08    -94.19                                   
REMARK 500    PHE C 285      -60.82    -90.94                                   
REMARK 500    LYS C 305       30.27    -99.76                                   
REMARK 500    PRO D  28     -166.98    -78.75                                   
REMARK 500    ILE E 312      -63.78   -109.12                                   
REMARK 500    SER E 416     -158.85   -150.24                                   
REMARK 500    ALA E 451       32.93    -98.44                                   
REMARK 500    ARG E 467       73.92   -101.67                                   
REMARK 500    SER E 481       33.21    -98.59                                   
REMARK 500    ASN F 245       27.55     46.74                                   
REMARK 500    ALA F 451       33.67    -96.73                                   
REMARK 500    SER F 481       33.09    -98.19                                   
REMARK 500    SER G 155       69.01     60.66                                   
REMARK 500    SER H 155       69.06     60.65                                   
REMARK 500    LYS I  61       52.87    -92.51                                   
REMARK 500    LYS J  61       52.90    -92.54                                   
REMARK 500    ASP L 166       40.04   -105.35                                   
REMARK 500    MET L 222       67.35   -159.91                                   
REMARK 500    THR S  29       86.92   -150.89                                   
REMARK 500    HIS S  33       31.88    -98.39                                   
REMARK 500    VAL S 127      -58.68   -120.81                                   
REMARK 500    LEU S 146       53.11    -92.26                                   
REMARK 500    ALA S 216      -65.64    -95.79                                   
REMARK 500    LYS S 342       58.27    -94.80                                   
REMARK 500    ALA S 422      -11.22     68.75                                   
REMARK 500    ASP S 423       -4.71   -143.25                                   
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 800                                                                      
REMARK 800 SITE                                                                 
REMARK 800 SITE_IDENTIFIER: AC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue C7B C 401                 
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: EMD-0651   RELATED DB: EMDB                              
REMARK 900 ELECTRON CRYO-MICROSCOPY OF THE EUKARYOTIC TRANSLATION INITIATION    
REMARK 900 FACTOR 2B BOUND EUKARYOTIC TRANSLATION INITIATION FACTOR 2 TO FROM   
REMARK 900 HOMO SAPIENS                                                         
DBREF  6O85 A    1   721  UNP    Q13144   EI2BE_HUMAN      1    721             
DBREF  6O85 B    1   721  UNP    Q13144   EI2BE_HUMAN      1    721             
DBREF  6O85 C    2   351  UNP    P49770   EI2BB_HUMAN      2    351             
DBREF  6O85 D    2   351  UNP    P49770   EI2BB_HUMAN      2    351             
DBREF  6O85 E    1   523  UNP    Q9UI10   EI2BD_HUMAN      1    523             
DBREF  6O85 F    1   523  UNP    Q9UI10   EI2BD_HUMAN      1    523             
DBREF  6O85 G    1   305  UNP    Q14232   EI2BA_HUMAN      1    305             
DBREF  6O85 H    1   305  UNP    Q14232   EI2BA_HUMAN      1    305             
DBREF  6O85 I    1   452  UNP    Q9NR50   EI2BG_HUMAN      1    452             
DBREF  6O85 J    1   452  UNP    Q9NR50   EI2BG_HUMAN      1    452             
DBREF  6O85 L    1   314  UNP    P05198   IF2A_HUMAN       2    315             
DBREF  6O85 S    1   472  UNP    P41091   IF2G_HUMAN       1    472             
DBREF  6O85 d    3    16  PDB    6O85     6O85             3     16             
SEQADV 6O85 MET C  -16  UNP  P49770              INITIATING METHIONINE          
SEQADV 6O85 HIS C  -15  UNP  P49770              EXPRESSION TAG                 
SEQADV 6O85 HIS C  -14  UNP  P49770              EXPRESSION TAG                 
SEQADV 6O85 HIS C  -13  UNP  P49770              EXPRESSION TAG                 
SEQADV 6O85 HIS C  -12  UNP  P49770              EXPRESSION TAG                 
SEQADV 6O85 HIS C  -11  UNP  P49770              EXPRESSION TAG                 
SEQADV 6O85 HIS C  -10  UNP  P49770              EXPRESSION TAG                 
SEQADV 6O85 GLY C   -9  UNP  P49770              EXPRESSION TAG                 
SEQADV 6O85 GLY C   -8  UNP  P49770              EXPRESSION TAG                 
SEQADV 6O85 GLY C   -7  UNP  P49770              EXPRESSION TAG                 
SEQADV 6O85 SER C   -6  UNP  P49770              EXPRESSION TAG                 
SEQADV 6O85 GLU C   -5  UNP  P49770              EXPRESSION TAG                 
SEQADV 6O85 ASN C   -4  UNP  P49770              EXPRESSION TAG                 
SEQADV 6O85 LEU C   -3  UNP  P49770              EXPRESSION TAG                 
SEQADV 6O85 TYR C   -2  UNP  P49770              EXPRESSION TAG                 
SEQADV 6O85 PHE C   -1  UNP  P49770              EXPRESSION TAG                 
SEQADV 6O85 GLN C    0  UNP  P49770              EXPRESSION TAG                 
SEQADV 6O85 SER C    1  UNP  P49770              EXPRESSION TAG                 
SEQADV 6O85 MET D  -16  UNP  P49770              INITIATING METHIONINE          
SEQADV 6O85 HIS D  -15  UNP  P49770              EXPRESSION TAG                 
SEQADV 6O85 HIS D  -14  UNP  P49770              EXPRESSION TAG                 
SEQADV 6O85 HIS D  -13  UNP  P49770              EXPRESSION TAG                 
SEQADV 6O85 HIS D  -12  UNP  P49770              EXPRESSION TAG                 
SEQADV 6O85 HIS D  -11  UNP  P49770              EXPRESSION TAG                 
SEQADV 6O85 HIS D  -10  UNP  P49770              EXPRESSION TAG                 
SEQADV 6O85 GLY D   -9  UNP  P49770              EXPRESSION TAG                 
SEQADV 6O85 GLY D   -8  UNP  P49770              EXPRESSION TAG                 
SEQADV 6O85 GLY D   -7  UNP  P49770              EXPRESSION TAG                 
SEQADV 6O85 SER D   -6  UNP  P49770              EXPRESSION TAG                 
SEQADV 6O85 GLU D   -5  UNP  P49770              EXPRESSION TAG                 
SEQADV 6O85 ASN D   -4  UNP  P49770              EXPRESSION TAG                 
SEQADV 6O85 LEU D   -3  UNP  P49770              EXPRESSION TAG                 
SEQADV 6O85 TYR D   -2  UNP  P49770              EXPRESSION TAG                 
SEQADV 6O85 PHE D   -1  UNP  P49770              EXPRESSION TAG                 
SEQADV 6O85 GLN D    0  UNP  P49770              EXPRESSION TAG                 
SEQADV 6O85 SER D    1  UNP  P49770              EXPRESSION TAG                 
SEQRES   1 A  721  MET ALA ALA PRO VAL VAL ALA PRO PRO GLY VAL VAL VAL          
SEQRES   2 A  721  SER ARG ALA ASN LYS ARG SER GLY ALA GLY PRO GLY GLY          
SEQRES   3 A  721  SER GLY GLY GLY GLY ALA ARG GLY ALA GLU GLU GLU PRO          
SEQRES   4 A  721  PRO PRO PRO LEU GLN ALA VAL LEU VAL ALA ASP SER PHE          
SEQRES   5 A  721  ASP ARG ARG PHE PHE PRO ILE SER LYS ASP GLN PRO ARG          
SEQRES   6 A  721  VAL LEU LEU PRO LEU ALA ASN VAL ALA LEU ILE ASP TYR          
SEQRES   7 A  721  THR LEU GLU PHE LEU THR ALA THR GLY VAL GLN GLU THR          
SEQRES   8 A  721  PHE VAL PHE CYS CYS TRP LYS ALA ALA GLN ILE LYS GLU          
SEQRES   9 A  721  HIS LEU LEU LYS SER LYS TRP CYS ARG PRO THR SER LEU          
SEQRES  10 A  721  ASN VAL VAL ARG ILE ILE THR SER GLU LEU TYR ARG SER          
SEQRES  11 A  721  LEU GLY ASP VAL LEU ARG ASP VAL ASP ALA LYS ALA LEU          
SEQRES  12 A  721  VAL ARG SER ASP PHE LEU LEU VAL TYR GLY ASP VAL ILE          
SEQRES  13 A  721  SER ASN ILE ASN ILE THR ARG ALA LEU GLU GLU HIS ARG          
SEQRES  14 A  721  LEU ARG ARG LYS LEU GLU LYS ASN VAL SER VAL MET THR          
SEQRES  15 A  721  MET ILE PHE LYS GLU SER SER PRO SER HIS PRO THR ARG          
SEQRES  16 A  721  CYS HIS GLU ASP ASN VAL VAL VAL ALA VAL ASP SER THR          
SEQRES  17 A  721  THR ASN ARG VAL LEU HIS PHE GLN LYS THR GLN GLY LEU          
SEQRES  18 A  721  ARG ARG PHE ALA PHE PRO LEU SER LEU PHE GLN GLY SER          
SEQRES  19 A  721  SER ASP GLY VAL GLU VAL ARG TYR ASP LEU LEU ASP CYS          
SEQRES  20 A  721  HIS ILE SER ILE CYS SER PRO GLN VAL ALA GLN LEU PHE          
SEQRES  21 A  721  THR ASP ASN PHE ASP TYR GLN THR ARG ASP ASP PHE VAL          
SEQRES  22 A  721  ARG GLY LEU LEU VAL ASN GLU GLU ILE LEU GLY ASN GLN          
SEQRES  23 A  721  ILE HIS MET HIS VAL THR ALA LYS GLU TYR GLY ALA ARG          
SEQRES  24 A  721  VAL SER ASN LEU HIS MET TYR SER ALA VAL CYS ALA ASP          
SEQRES  25 A  721  VAL ILE ARG ARG TRP VAL TYR PRO LEU THR PRO GLU ALA          
SEQRES  26 A  721  ASN PHE THR ASP SER THR THR GLN SER CYS THR HIS SER          
SEQRES  27 A  721  ARG HIS ASN ILE TYR ARG GLY PRO GLU VAL SER LEU GLY          
SEQRES  28 A  721  HIS GLY SER ILE LEU GLU GLU ASN VAL LEU LEU GLY SER          
SEQRES  29 A  721  GLY THR VAL ILE GLY SER ASN CYS PHE ILE THR ASN SER          
SEQRES  30 A  721  VAL ILE GLY PRO GLY CYS HIS ILE GLY ASP ASN VAL VAL          
SEQRES  31 A  721  LEU ASP GLN THR TYR LEU TRP GLN GLY VAL ARG VAL ALA          
SEQRES  32 A  721  ALA GLY ALA GLN ILE HIS GLN SER LEU LEU CYS ASP ASN          
SEQRES  33 A  721  ALA GLU VAL LYS GLU ARG VAL THR LEU LYS PRO ARG SER          
SEQRES  34 A  721  VAL LEU THR SER GLN VAL VAL VAL GLY PRO ASN ILE THR          
SEQRES  35 A  721  LEU PRO GLU GLY SER VAL ILE SER LEU HIS PRO PRO ASP          
SEQRES  36 A  721  ALA GLU GLU ASP GLU ASP ASP GLY GLU PHE SER ASP ASP          
SEQRES  37 A  721  SER GLY ALA ASP GLN GLU LYS ASP LYS VAL LYS MET LYS          
SEQRES  38 A  721  GLY TYR ASN PRO ALA GLU VAL GLY ALA ALA GLY LYS GLY          
SEQRES  39 A  721  TYR LEU TRP LYS ALA ALA GLY MET ASN MET GLU GLU GLU          
SEQRES  40 A  721  GLU GLU LEU GLN GLN ASN LEU TRP GLY LEU LYS ILE ASN          
SEQRES  41 A  721  MET GLU GLU GLU SER GLU SER GLU SER GLU GLN SER MET          
SEQRES  42 A  721  ASP SER GLU GLU PRO ASP SER ARG GLY GLY SER PRO GLN          
SEQRES  43 A  721  MET ASP ASP ILE LYS VAL PHE GLN ASN GLU VAL LEU GLY          
SEQRES  44 A  721  THR LEU GLN ARG GLY LYS GLU GLU ASN ILE SER CYS ASP          
SEQRES  45 A  721  ASN LEU VAL LEU GLU ILE ASN SER LEU LYS TYR ALA TYR          
SEQRES  46 A  721  ASN ILE SER LEU LYS GLU VAL MET GLN VAL LEU SER HIS          
SEQRES  47 A  721  VAL VAL LEU GLU PHE PRO LEU GLN GLN MET ASP SER PRO          
SEQRES  48 A  721  LEU ASP SER SER ARG TYR CYS ALA LEU LEU LEU PRO LEU          
SEQRES  49 A  721  LEU LYS ALA TRP SER PRO VAL PHE ARG ASN TYR ILE LYS          
SEQRES  50 A  721  ARG ALA ALA ASP HIS LEU GLU ALA LEU ALA ALA ILE GLU          
SEQRES  51 A  721  ASP PHE PHE LEU GLU HIS GLU ALA LEU GLY ILE SER MET          
SEQRES  52 A  721  ALA LYS VAL LEU MET ALA PHE TYR GLN LEU GLU ILE LEU          
SEQRES  53 A  721  ALA GLU GLU THR ILE LEU SER TRP PHE SER GLN ARG ASP          
SEQRES  54 A  721  THR THR ASP LYS GLY GLN GLN LEU ARG LYS ASN GLN GLN          
SEQRES  55 A  721  LEU GLN ARG PHE ILE GLN TRP LEU LYS GLU ALA GLU GLU          
SEQRES  56 A  721  GLU SER SER GLU ASP ASP                                      
SEQRES   1 B  721  MET ALA ALA PRO VAL VAL ALA PRO PRO GLY VAL VAL VAL          
SEQRES   2 B  721  SER ARG ALA ASN LYS ARG SER GLY ALA GLY PRO GLY GLY          
SEQRES   3 B  721  SER GLY GLY GLY GLY ALA ARG GLY ALA GLU GLU GLU PRO          
SEQRES   4 B  721  PRO PRO PRO LEU GLN ALA VAL LEU VAL ALA ASP SER PHE          
SEQRES   5 B  721  ASP ARG ARG PHE PHE PRO ILE SER LYS ASP GLN PRO ARG          
SEQRES   6 B  721  VAL LEU LEU PRO LEU ALA ASN VAL ALA LEU ILE ASP TYR          
SEQRES   7 B  721  THR LEU GLU PHE LEU THR ALA THR GLY VAL GLN GLU THR          
SEQRES   8 B  721  PHE VAL PHE CYS CYS TRP LYS ALA ALA GLN ILE LYS GLU          
SEQRES   9 B  721  HIS LEU LEU LYS SER LYS TRP CYS ARG PRO THR SER LEU          
SEQRES  10 B  721  ASN VAL VAL ARG ILE ILE THR SER GLU LEU TYR ARG SER          
SEQRES  11 B  721  LEU GLY ASP VAL LEU ARG ASP VAL ASP ALA LYS ALA LEU          
SEQRES  12 B  721  VAL ARG SER ASP PHE LEU LEU VAL TYR GLY ASP VAL ILE          
SEQRES  13 B  721  SER ASN ILE ASN ILE THR ARG ALA LEU GLU GLU HIS ARG          
SEQRES  14 B  721  LEU ARG ARG LYS LEU GLU LYS ASN VAL SER VAL MET THR          
SEQRES  15 B  721  MET ILE PHE LYS GLU SER SER PRO SER HIS PRO THR ARG          
SEQRES  16 B  721  CYS HIS GLU ASP ASN VAL VAL VAL ALA VAL ASP SER THR          
SEQRES  17 B  721  THR ASN ARG VAL LEU HIS PHE GLN LYS THR GLN GLY LEU          
SEQRES  18 B  721  ARG ARG PHE ALA PHE PRO LEU SER LEU PHE GLN GLY SER          
SEQRES  19 B  721  SER ASP GLY VAL GLU VAL ARG TYR ASP LEU LEU ASP CYS          
SEQRES  20 B  721  HIS ILE SER ILE CYS SER PRO GLN VAL ALA GLN LEU PHE          
SEQRES  21 B  721  THR ASP ASN PHE ASP TYR GLN THR ARG ASP ASP PHE VAL          
SEQRES  22 B  721  ARG GLY LEU LEU VAL ASN GLU GLU ILE LEU GLY ASN GLN          
SEQRES  23 B  721  ILE HIS MET HIS VAL THR ALA LYS GLU TYR GLY ALA ARG          
SEQRES  24 B  721  VAL SER ASN LEU HIS MET TYR SER ALA VAL CYS ALA ASP          
SEQRES  25 B  721  VAL ILE ARG ARG TRP VAL TYR PRO LEU THR PRO GLU ALA          
SEQRES  26 B  721  ASN PHE THR ASP SER THR THR GLN SER CYS THR HIS SER          
SEQRES  27 B  721  ARG HIS ASN ILE TYR ARG GLY PRO GLU VAL SER LEU GLY          
SEQRES  28 B  721  HIS GLY SER ILE LEU GLU GLU ASN VAL LEU LEU GLY SER          
SEQRES  29 B  721  GLY THR VAL ILE GLY SER ASN CYS PHE ILE THR ASN SER          
SEQRES  30 B  721  VAL ILE GLY PRO GLY CYS HIS ILE GLY ASP ASN VAL VAL          
SEQRES  31 B  721  LEU ASP GLN THR TYR LEU TRP GLN GLY VAL ARG VAL ALA          
SEQRES  32 B  721  ALA GLY ALA GLN ILE HIS GLN SER LEU LEU CYS ASP ASN          
SEQRES  33 B  721  ALA GLU VAL LYS GLU ARG VAL THR LEU LYS PRO ARG SER          
SEQRES  34 B  721  VAL LEU THR SER GLN VAL VAL VAL GLY PRO ASN ILE THR          
SEQRES  35 B  721  LEU PRO GLU GLY SER VAL ILE SER LEU HIS PRO PRO ASP          
SEQRES  36 B  721  ALA GLU GLU ASP GLU ASP ASP GLY GLU PHE SER ASP ASP          
SEQRES  37 B  721  SER GLY ALA ASP GLN GLU LYS ASP LYS VAL LYS MET LYS          
SEQRES  38 B  721  GLY TYR ASN PRO ALA GLU VAL GLY ALA ALA GLY LYS GLY          
SEQRES  39 B  721  TYR LEU TRP LYS ALA ALA GLY MET ASN MET GLU GLU GLU          
SEQRES  40 B  721  GLU GLU LEU GLN GLN ASN LEU TRP GLY LEU LYS ILE ASN          
SEQRES  41 B  721  MET GLU GLU GLU SER GLU SER GLU SER GLU GLN SER MET          
SEQRES  42 B  721  ASP SER GLU GLU PRO ASP SER ARG GLY GLY SER PRO GLN          
SEQRES  43 B  721  MET ASP ASP ILE LYS VAL PHE GLN ASN GLU VAL LEU GLY          
SEQRES  44 B  721  THR LEU GLN ARG GLY LYS GLU GLU ASN ILE SER CYS ASP          
SEQRES  45 B  721  ASN LEU VAL LEU GLU ILE ASN SER LEU LYS TYR ALA TYR          
SEQRES  46 B  721  ASN ILE SER LEU LYS GLU VAL MET GLN VAL LEU SER HIS          
SEQRES  47 B  721  VAL VAL LEU GLU PHE PRO LEU GLN GLN MET ASP SER PRO          
SEQRES  48 B  721  LEU ASP SER SER ARG TYR CYS ALA LEU LEU LEU PRO LEU          
SEQRES  49 B  721  LEU LYS ALA TRP SER PRO VAL PHE ARG ASN TYR ILE LYS          
SEQRES  50 B  721  ARG ALA ALA ASP HIS LEU GLU ALA LEU ALA ALA ILE GLU          
SEQRES  51 B  721  ASP PHE PHE LEU GLU HIS GLU ALA LEU GLY ILE SER MET          
SEQRES  52 B  721  ALA LYS VAL LEU MET ALA PHE TYR GLN LEU GLU ILE LEU          
SEQRES  53 B  721  ALA GLU GLU THR ILE LEU SER TRP PHE SER GLN ARG ASP          
SEQRES  54 B  721  THR THR ASP LYS GLY GLN GLN LEU ARG LYS ASN GLN GLN          
SEQRES  55 B  721  LEU GLN ARG PHE ILE GLN TRP LEU LYS GLU ALA GLU GLU          
SEQRES  56 B  721  GLU SER SER GLU ASP ASP                                      
SEQRES   1 C  368  MET HIS HIS HIS HIS HIS HIS GLY GLY GLY SER GLU ASN          
SEQRES   2 C  368  LEU TYR PHE GLN SER PRO GLY SER ALA ALA LYS GLY SER          
SEQRES   3 C  368  GLU LEU SER GLU ARG ILE GLU SER PHE VAL GLU THR LEU          
SEQRES   4 C  368  LYS ARG GLY GLY GLY PRO ARG SER SER GLU GLU MET ALA          
SEQRES   5 C  368  ARG GLU THR LEU GLY LEU LEU ARG GLN ILE ILE THR ASP          
SEQRES   6 C  368  HIS ARG TRP SER ASN ALA GLY GLU LEU MET GLU LEU ILE          
SEQRES   7 C  368  ARG ARG GLU GLY ARG ARG MET THR ALA ALA GLN PRO SER          
SEQRES   8 C  368  GLU THR THR VAL GLY ASN MET VAL ARG ARG VAL LEU LYS          
SEQRES   9 C  368  ILE ILE ARG GLU GLU TYR GLY ARG LEU HIS GLY ARG SER          
SEQRES  10 C  368  ASP GLU SER ASP GLN GLN GLU SER LEU HIS LYS LEU LEU          
SEQRES  11 C  368  THR SER GLY GLY LEU ASN GLU ASP PHE SER PHE HIS TYR          
SEQRES  12 C  368  ALA GLN LEU GLN SER ASN ILE ILE GLU ALA ILE ASN GLU          
SEQRES  13 C  368  LEU LEU VAL GLU LEU GLU GLY THR MET GLU ASN ILE ALA          
SEQRES  14 C  368  ALA GLN ALA LEU GLU HIS ILE HIS SER ASN GLU VAL ILE          
SEQRES  15 C  368  MET THR ILE GLY PHE SER ARG THR VAL GLU ALA PHE LEU          
SEQRES  16 C  368  LYS GLU ALA ALA ARG LYS ARG LYS PHE HIS VAL ILE VAL          
SEQRES  17 C  368  ALA GLU CYS ALA PRO PHE CYS GLN GLY HIS GLU MET ALA          
SEQRES  18 C  368  VAL ASN LEU SER LYS ALA GLY ILE GLU THR THR VAL MET          
SEQRES  19 C  368  THR ASP ALA ALA ILE PHE ALA VAL MET SER ARG VAL ASN          
SEQRES  20 C  368  LYS VAL ILE ILE GLY THR LYS THR ILE LEU ALA ASN GLY          
SEQRES  21 C  368  ALA LEU ARG ALA VAL THR GLY THR HIS THR LEU ALA LEU          
SEQRES  22 C  368  ALA ALA LYS HIS HIS SER THR PRO LEU ILE VAL CYS ALA          
SEQRES  23 C  368  PRO MET PHE LYS LEU SER PRO GLN PHE PRO ASN GLU GLU          
SEQRES  24 C  368  ASP SER PHE HIS LYS PHE VAL ALA PRO GLU GLU VAL LEU          
SEQRES  25 C  368  PRO PHE THR GLU GLY ASP ILE LEU GLU LYS VAL SER VAL          
SEQRES  26 C  368  HIS CYS PRO VAL PHE ASP TYR VAL PRO PRO GLU LEU ILE          
SEQRES  27 C  368  THR LEU PHE ILE SER ASN ILE GLY GLY ASN ALA PRO SER          
SEQRES  28 C  368  TYR ILE TYR ARG LEU MET SER GLU LEU TYR HIS PRO ASP          
SEQRES  29 C  368  ASP HIS VAL LEU                                              
SEQRES   1 D  368  MET HIS HIS HIS HIS HIS HIS GLY GLY GLY SER GLU ASN          
SEQRES   2 D  368  LEU TYR PHE GLN SER PRO GLY SER ALA ALA LYS GLY SER          
SEQRES   3 D  368  GLU LEU SER GLU ARG ILE GLU SER PHE VAL GLU THR LEU          
SEQRES   4 D  368  LYS ARG GLY GLY GLY PRO ARG SER SER GLU GLU MET ALA          
SEQRES   5 D  368  ARG GLU THR LEU GLY LEU LEU ARG GLN ILE ILE THR ASP          
SEQRES   6 D  368  HIS ARG TRP SER ASN ALA GLY GLU LEU MET GLU LEU ILE          
SEQRES   7 D  368  ARG ARG GLU GLY ARG ARG MET THR ALA ALA GLN PRO SER          
SEQRES   8 D  368  GLU THR THR VAL GLY ASN MET VAL ARG ARG VAL LEU LYS          
SEQRES   9 D  368  ILE ILE ARG GLU GLU TYR GLY ARG LEU HIS GLY ARG SER          
SEQRES  10 D  368  ASP GLU SER ASP GLN GLN GLU SER LEU HIS LYS LEU LEU          
SEQRES  11 D  368  THR SER GLY GLY LEU ASN GLU ASP PHE SER PHE HIS TYR          
SEQRES  12 D  368  ALA GLN LEU GLN SER ASN ILE ILE GLU ALA ILE ASN GLU          
SEQRES  13 D  368  LEU LEU VAL GLU LEU GLU GLY THR MET GLU ASN ILE ALA          
SEQRES  14 D  368  ALA GLN ALA LEU GLU HIS ILE HIS SER ASN GLU VAL ILE          
SEQRES  15 D  368  MET THR ILE GLY PHE SER ARG THR VAL GLU ALA PHE LEU          
SEQRES  16 D  368  LYS GLU ALA ALA ARG LYS ARG LYS PHE HIS VAL ILE VAL          
SEQRES  17 D  368  ALA GLU CYS ALA PRO PHE CYS GLN GLY HIS GLU MET ALA          
SEQRES  18 D  368  VAL ASN LEU SER LYS ALA GLY ILE GLU THR THR VAL MET          
SEQRES  19 D  368  THR ASP ALA ALA ILE PHE ALA VAL MET SER ARG VAL ASN          
SEQRES  20 D  368  LYS VAL ILE ILE GLY THR LYS THR ILE LEU ALA ASN GLY          
SEQRES  21 D  368  ALA LEU ARG ALA VAL THR GLY THR HIS THR LEU ALA LEU          
SEQRES  22 D  368  ALA ALA LYS HIS HIS SER THR PRO LEU ILE VAL CYS ALA          
SEQRES  23 D  368  PRO MET PHE LYS LEU SER PRO GLN PHE PRO ASN GLU GLU          
SEQRES  24 D  368  ASP SER PHE HIS LYS PHE VAL ALA PRO GLU GLU VAL LEU          
SEQRES  25 D  368  PRO PHE THR GLU GLY ASP ILE LEU GLU LYS VAL SER VAL          
SEQRES  26 D  368  HIS CYS PRO VAL PHE ASP TYR VAL PRO PRO GLU LEU ILE          
SEQRES  27 D  368  THR LEU PHE ILE SER ASN ILE GLY GLY ASN ALA PRO SER          
SEQRES  28 D  368  TYR ILE TYR ARG LEU MET SER GLU LEU TYR HIS PRO ASP          
SEQRES  29 D  368  ASP HIS VAL LEU                                              
SEQRES   1 E  523  MET ALA ALA VAL ALA VAL ALA VAL ARG GLU ASP SER GLY          
SEQRES   2 E  523  SER GLY MET LYS ALA GLU LEU PRO PRO GLY PRO GLY ALA          
SEQRES   3 E  523  VAL GLY ARG GLU MET THR LYS GLU GLU LYS LEU GLN LEU          
SEQRES   4 E  523  ARG LYS GLU LYS LYS GLN GLN LYS LYS LYS ARG LYS GLU          
SEQRES   5 E  523  GLU LYS GLY ALA GLU PRO GLU THR GLY SER ALA VAL SER          
SEQRES   6 E  523  ALA ALA GLN CYS GLN VAL GLY PRO THR ARG GLU LEU PRO          
SEQRES   7 E  523  GLU SER GLY ILE GLN LEU GLY THR PRO ARG GLU LYS VAL          
SEQRES   8 E  523  PRO ALA GLY ARG SER LYS ALA GLU LEU ARG ALA GLU ARG          
SEQRES   9 E  523  ARG ALA LYS GLN GLU ALA GLU ARG ALA LEU LYS GLN ALA          
SEQRES  10 E  523  ARG LYS GLY GLU GLN GLY GLY PRO PRO PRO LYS ALA SER          
SEQRES  11 E  523  PRO SER THR ALA GLY GLU THR PRO SER GLY VAL LYS ARG          
SEQRES  12 E  523  LEU PRO GLU TYR PRO GLN VAL ASP ASP LEU LEU LEU ARG          
SEQRES  13 E  523  ARG LEU VAL LYS LYS PRO GLU ARG GLN GLN VAL PRO THR          
SEQRES  14 E  523  ARG LYS ASP TYR GLY SER LYS VAL SER LEU PHE SER HIS          
SEQRES  15 E  523  LEU PRO GLN TYR SER ARG GLN ASN SER LEU THR GLN PHE          
SEQRES  16 E  523  MET SER ILE PRO SER SER VAL ILE HIS PRO ALA MET VAL          
SEQRES  17 E  523  ARG LEU GLY LEU GLN TYR SER GLN GLY LEU VAL SER GLY          
SEQRES  18 E  523  SER ASN ALA ARG CYS ILE ALA LEU LEU ARG ALA LEU GLN          
SEQRES  19 E  523  GLN VAL ILE GLN ASP TYR THR THR PRO PRO ASN GLU GLU          
SEQRES  20 E  523  LEU SER ARG ASP LEU VAL ASN LYS LEU LYS PRO TYR MET          
SEQRES  21 E  523  SER PHE LEU THR GLN CYS ARG PRO LEU SER ALA SER MET          
SEQRES  22 E  523  HIS ASN ALA ILE LYS PHE LEU ASN LYS GLU ILE THR SER          
SEQRES  23 E  523  VAL GLY SER SER LYS ARG GLU GLU GLU ALA LYS SER GLU          
SEQRES  24 E  523  LEU ARG ALA ALA ILE ASP ARG TYR VAL GLN GLU LYS ILE          
SEQRES  25 E  523  VAL LEU ALA ALA GLN ALA ILE SER ARG PHE ALA TYR GLN          
SEQRES  26 E  523  LYS ILE SER ASN GLY ASP VAL ILE LEU VAL TYR GLY CYS          
SEQRES  27 E  523  SER SER LEU VAL SER ARG ILE LEU GLN GLU ALA TRP THR          
SEQRES  28 E  523  GLU GLY ARG ARG PHE ARG VAL VAL VAL VAL ASP SER ARG          
SEQRES  29 E  523  PRO TRP LEU GLU GLY ARG HIS THR LEU ARG SER LEU VAL          
SEQRES  30 E  523  HIS ALA GLY VAL PRO ALA SER TYR LEU LEU ILE PRO ALA          
SEQRES  31 E  523  ALA SER TYR VAL LEU PRO GLU VAL SER LYS VAL LEU LEU          
SEQRES  32 E  523  GLY ALA HIS ALA LEU LEU ALA ASN GLY SER VAL MET SER          
SEQRES  33 E  523  ARG VAL GLY THR ALA GLN LEU ALA LEU VAL ALA ARG ALA          
SEQRES  34 E  523  HIS ASN VAL PRO VAL LEU VAL CYS CYS GLU THR TYR LYS          
SEQRES  35 E  523  PHE CYS GLU ARG VAL GLN THR ASP ALA PHE VAL SER ASN          
SEQRES  36 E  523  GLU LEU ASP ASP PRO ASP ASP LEU GLN CYS LYS ARG GLY          
SEQRES  37 E  523  GLU HIS VAL ALA LEU ALA ASN TRP GLN ASN HIS ALA SER          
SEQRES  38 E  523  LEU ARG LEU LEU ASN LEU VAL TYR ASP VAL THR PRO PRO          
SEQRES  39 E  523  GLU LEU VAL ASP LEU VAL ILE THR GLU LEU GLY MET ILE          
SEQRES  40 E  523  PRO CYS SER SER VAL PRO VAL VAL LEU ARG VAL LYS SER          
SEQRES  41 E  523  SER ASP GLN                                                  
SEQRES   1 F  523  MET ALA ALA VAL ALA VAL ALA VAL ARG GLU ASP SER GLY          
SEQRES   2 F  523  SER GLY MET LYS ALA GLU LEU PRO PRO GLY PRO GLY ALA          
SEQRES   3 F  523  VAL GLY ARG GLU MET THR LYS GLU GLU LYS LEU GLN LEU          
SEQRES   4 F  523  ARG LYS GLU LYS LYS GLN GLN LYS LYS LYS ARG LYS GLU          
SEQRES   5 F  523  GLU LYS GLY ALA GLU PRO GLU THR GLY SER ALA VAL SER          
SEQRES   6 F  523  ALA ALA GLN CYS GLN VAL GLY PRO THR ARG GLU LEU PRO          
SEQRES   7 F  523  GLU SER GLY ILE GLN LEU GLY THR PRO ARG GLU LYS VAL          
SEQRES   8 F  523  PRO ALA GLY ARG SER LYS ALA GLU LEU ARG ALA GLU ARG          
SEQRES   9 F  523  ARG ALA LYS GLN GLU ALA GLU ARG ALA LEU LYS GLN ALA          
SEQRES  10 F  523  ARG LYS GLY GLU GLN GLY GLY PRO PRO PRO LYS ALA SER          
SEQRES  11 F  523  PRO SER THR ALA GLY GLU THR PRO SER GLY VAL LYS ARG          
SEQRES  12 F  523  LEU PRO GLU TYR PRO GLN VAL ASP ASP LEU LEU LEU ARG          
SEQRES  13 F  523  ARG LEU VAL LYS LYS PRO GLU ARG GLN GLN VAL PRO THR          
SEQRES  14 F  523  ARG LYS ASP TYR GLY SER LYS VAL SER LEU PHE SER HIS          
SEQRES  15 F  523  LEU PRO GLN TYR SER ARG GLN ASN SER LEU THR GLN PHE          
SEQRES  16 F  523  MET SER ILE PRO SER SER VAL ILE HIS PRO ALA MET VAL          
SEQRES  17 F  523  ARG LEU GLY LEU GLN TYR SER GLN GLY LEU VAL SER GLY          
SEQRES  18 F  523  SER ASN ALA ARG CYS ILE ALA LEU LEU ARG ALA LEU GLN          
SEQRES  19 F  523  GLN VAL ILE GLN ASP TYR THR THR PRO PRO ASN GLU GLU          
SEQRES  20 F  523  LEU SER ARG ASP LEU VAL ASN LYS LEU LYS PRO TYR MET          
SEQRES  21 F  523  SER PHE LEU THR GLN CYS ARG PRO LEU SER ALA SER MET          
SEQRES  22 F  523  HIS ASN ALA ILE LYS PHE LEU ASN LYS GLU ILE THR SER          
SEQRES  23 F  523  VAL GLY SER SER LYS ARG GLU GLU GLU ALA LYS SER GLU          
SEQRES  24 F  523  LEU ARG ALA ALA ILE ASP ARG TYR VAL GLN GLU LYS ILE          
SEQRES  25 F  523  VAL LEU ALA ALA GLN ALA ILE SER ARG PHE ALA TYR GLN          
SEQRES  26 F  523  LYS ILE SER ASN GLY ASP VAL ILE LEU VAL TYR GLY CYS          
SEQRES  27 F  523  SER SER LEU VAL SER ARG ILE LEU GLN GLU ALA TRP THR          
SEQRES  28 F  523  GLU GLY ARG ARG PHE ARG VAL VAL VAL VAL ASP SER ARG          
SEQRES  29 F  523  PRO TRP LEU GLU GLY ARG HIS THR LEU ARG SER LEU VAL          
SEQRES  30 F  523  HIS ALA GLY VAL PRO ALA SER TYR LEU LEU ILE PRO ALA          
SEQRES  31 F  523  ALA SER TYR VAL LEU PRO GLU VAL SER LYS VAL LEU LEU          
SEQRES  32 F  523  GLY ALA HIS ALA LEU LEU ALA ASN GLY SER VAL MET SER          
SEQRES  33 F  523  ARG VAL GLY THR ALA GLN LEU ALA LEU VAL ALA ARG ALA          
SEQRES  34 F  523  HIS ASN VAL PRO VAL LEU VAL CYS CYS GLU THR TYR LYS          
SEQRES  35 F  523  PHE CYS GLU ARG VAL GLN THR ASP ALA PHE VAL SER ASN          
SEQRES  36 F  523  GLU LEU ASP ASP PRO ASP ASP LEU GLN CYS LYS ARG GLY          
SEQRES  37 F  523  GLU HIS VAL ALA LEU ALA ASN TRP GLN ASN HIS ALA SER          
SEQRES  38 F  523  LEU ARG LEU LEU ASN LEU VAL TYR ASP VAL THR PRO PRO          
SEQRES  39 F  523  GLU LEU VAL ASP LEU VAL ILE THR GLU LEU GLY MET ILE          
SEQRES  40 F  523  PRO CYS SER SER VAL PRO VAL VAL LEU ARG VAL LYS SER          
SEQRES  41 F  523  SER ASP GLN                                                  
SEQRES   1 G  305  MET ASP ASP LYS GLU LEU ILE GLU TYR PHE LYS SER GLN          
SEQRES   2 G  305  MET LYS GLU ASP PRO ASP MET ALA SER ALA VAL ALA ALA          
SEQRES   3 G  305  ILE ARG THR LEU LEU GLU PHE LEU LYS ARG ASP LYS GLY          
SEQRES   4 G  305  GLU THR ILE GLN GLY LEU ARG ALA ASN LEU THR SER ALA          
SEQRES   5 G  305  ILE GLU THR LEU CYS GLY VAL ASP SER SER VAL ALA VAL          
SEQRES   6 G  305  SER SER GLY GLY GLU LEU PHE LEU ARG PHE ILE SER LEU          
SEQRES   7 G  305  ALA SER LEU GLU TYR SER ASP TYR SER LYS CYS LYS LYS          
SEQRES   8 G  305  ILE MET ILE GLU ARG GLY GLU LEU PHE LEU ARG ARG ILE          
SEQRES   9 G  305  SER LEU SER ARG ASN LYS ILE ALA ASP LEU CYS HIS THR          
SEQRES  10 G  305  PHE ILE LYS ASP GLY ALA THR ILE LEU THR HIS ALA TYR          
SEQRES  11 G  305  SER ARG VAL VAL LEU ARG VAL LEU GLU ALA ALA VAL ALA          
SEQRES  12 G  305  ALA LYS LYS ARG PHE SER VAL TYR VAL THR GLU SER GLN          
SEQRES  13 G  305  PRO ASP LEU SER GLY LYS LYS MET ALA LYS ALA LEU CYS          
SEQRES  14 G  305  HIS LEU ASN VAL PRO VAL THR VAL VAL LEU ASP ALA ALA          
SEQRES  15 G  305  VAL GLY TYR ILE MET GLU LYS ALA ASP LEU VAL ILE VAL          
SEQRES  16 G  305  GLY ALA GLU GLY VAL VAL GLU ASN GLY GLY ILE ILE ASN          
SEQRES  17 G  305  LYS ILE GLY THR ASN GLN MET ALA VAL CYS ALA LYS ALA          
SEQRES  18 G  305  GLN ASN LYS PRO PHE TYR VAL VAL ALA GLU SER PHE LYS          
SEQRES  19 G  305  PHE VAL ARG LEU PHE PRO LEU ASN GLN GLN ASP VAL PRO          
SEQRES  20 G  305  ASP LYS PHE LYS TYR LYS ALA ASP THR LEU LYS VAL ALA          
SEQRES  21 G  305  GLN THR GLY GLN ASP LEU LYS GLU GLU HIS PRO TRP VAL          
SEQRES  22 G  305  ASP TYR THR ALA PRO SER LEU ILE THR LEU LEU PHE THR          
SEQRES  23 G  305  ASP LEU GLY VAL LEU THR PRO SER ALA VAL SER ASP GLU          
SEQRES  24 G  305  LEU ILE LYS LEU TYR LEU                                      
SEQRES   1 H  305  MET ASP ASP LYS GLU LEU ILE GLU TYR PHE LYS SER GLN          
SEQRES   2 H  305  MET LYS GLU ASP PRO ASP MET ALA SER ALA VAL ALA ALA          
SEQRES   3 H  305  ILE ARG THR LEU LEU GLU PHE LEU LYS ARG ASP LYS GLY          
SEQRES   4 H  305  GLU THR ILE GLN GLY LEU ARG ALA ASN LEU THR SER ALA          
SEQRES   5 H  305  ILE GLU THR LEU CYS GLY VAL ASP SER SER VAL ALA VAL          
SEQRES   6 H  305  SER SER GLY GLY GLU LEU PHE LEU ARG PHE ILE SER LEU          
SEQRES   7 H  305  ALA SER LEU GLU TYR SER ASP TYR SER LYS CYS LYS LYS          
SEQRES   8 H  305  ILE MET ILE GLU ARG GLY GLU LEU PHE LEU ARG ARG ILE          
SEQRES   9 H  305  SER LEU SER ARG ASN LYS ILE ALA ASP LEU CYS HIS THR          
SEQRES  10 H  305  PHE ILE LYS ASP GLY ALA THR ILE LEU THR HIS ALA TYR          
SEQRES  11 H  305  SER ARG VAL VAL LEU ARG VAL LEU GLU ALA ALA VAL ALA          
SEQRES  12 H  305  ALA LYS LYS ARG PHE SER VAL TYR VAL THR GLU SER GLN          
SEQRES  13 H  305  PRO ASP LEU SER GLY LYS LYS MET ALA LYS ALA LEU CYS          
SEQRES  14 H  305  HIS LEU ASN VAL PRO VAL THR VAL VAL LEU ASP ALA ALA          
SEQRES  15 H  305  VAL GLY TYR ILE MET GLU LYS ALA ASP LEU VAL ILE VAL          
SEQRES  16 H  305  GLY ALA GLU GLY VAL VAL GLU ASN GLY GLY ILE ILE ASN          
SEQRES  17 H  305  LYS ILE GLY THR ASN GLN MET ALA VAL CYS ALA LYS ALA          
SEQRES  18 H  305  GLN ASN LYS PRO PHE TYR VAL VAL ALA GLU SER PHE LYS          
SEQRES  19 H  305  PHE VAL ARG LEU PHE PRO LEU ASN GLN GLN ASP VAL PRO          
SEQRES  20 H  305  ASP LYS PHE LYS TYR LYS ALA ASP THR LEU LYS VAL ALA          
SEQRES  21 H  305  GLN THR GLY GLN ASP LEU LYS GLU GLU HIS PRO TRP VAL          
SEQRES  22 H  305  ASP TYR THR ALA PRO SER LEU ILE THR LEU LEU PHE THR          
SEQRES  23 H  305  ASP LEU GLY VAL LEU THR PRO SER ALA VAL SER ASP GLU          
SEQRES  24 H  305  LEU ILE LYS LEU TYR LEU                                      
SEQRES   1 I  452  MET GLU PHE GLN ALA VAL VAL MET ALA VAL GLY GLY GLY          
SEQRES   2 I  452  SER ARG MET THR ASP LEU THR SER SER ILE PRO LYS PRO          
SEQRES   3 I  452  LEU LEU PRO VAL GLY ASN LYS PRO LEU ILE TRP TYR PRO          
SEQRES   4 I  452  LEU ASN LEU LEU GLU ARG VAL GLY PHE GLU GLU VAL ILE          
SEQRES   5 I  452  VAL VAL THR THR ARG ASP VAL GLN LYS ALA LEU CYS ALA          
SEQRES   6 I  452  GLU PHE LYS MET LYS MET LYS PRO ASP ILE VAL CYS ILE          
SEQRES   7 I  452  PRO ASP ASP ALA ASP MET GLY THR ALA ASP SER LEU ARG          
SEQRES   8 I  452  TYR ILE TYR PRO LYS LEU LYS THR ASP VAL LEU VAL LEU          
SEQRES   9 I  452  SER CYS ASP LEU ILE THR ASP VAL ALA LEU HIS GLU VAL          
SEQRES  10 I  452  VAL ASP LEU PHE ARG ALA TYR ASP ALA SER LEU ALA MET          
SEQRES  11 I  452  LEU MET ARG LYS GLY GLN ASP SER ILE GLU PRO VAL PRO          
SEQRES  12 I  452  GLY GLN LYS GLY LYS LYS LYS ALA VAL GLU GLN ARG ASP          
SEQRES  13 I  452  PHE ILE GLY VAL ASP SER THR GLY LYS ARG LEU LEU PHE          
SEQRES  14 I  452  MET ALA ASN GLU ALA ASP LEU ASP GLU GLU LEU VAL ILE          
SEQRES  15 I  452  LYS GLY SER ILE LEU GLN LYS HIS PRO ARG ILE ARG PHE          
SEQRES  16 I  452  HIS THR GLY LEU VAL ASP ALA HIS LEU TYR CYS LEU LYS          
SEQRES  17 I  452  LYS TYR ILE VAL ASP PHE LEU MET GLU ASN GLY SER ILE          
SEQRES  18 I  452  THR SER ILE ARG SER GLU LEU ILE PRO TYR LEU VAL ARG          
SEQRES  19 I  452  LYS GLN PHE SER SER ALA SER SER GLN GLN GLY GLN GLU          
SEQRES  20 I  452  GLU LYS GLU GLU ASP LEU LYS LYS LYS GLU LEU LYS SER          
SEQRES  21 I  452  LEU ASP ILE TYR SER PHE ILE LYS GLU ALA ASN THR LEU          
SEQRES  22 I  452  ASN LEU ALA PRO TYR ASP ALA CYS TRP ASN ALA CYS ARG          
SEQRES  23 I  452  GLY ASP ARG TRP GLU ASP LEU SER ARG SER GLN VAL ARG          
SEQRES  24 I  452  CYS TYR VAL HIS ILE MET LYS GLU GLY LEU CYS SER ARG          
SEQRES  25 I  452  VAL SER THR LEU GLY LEU TYR MET GLU ALA ASN ARG GLN          
SEQRES  26 I  452  VAL PRO LYS LEU LEU SER ALA LEU CYS PRO GLU GLU PRO          
SEQRES  27 I  452  PRO VAL HIS SER SER ALA GLN ILE VAL SER LYS HIS LEU          
SEQRES  28 I  452  VAL GLY VAL ASP SER LEU ILE GLY PRO GLU THR GLN ILE          
SEQRES  29 I  452  GLY GLU LYS SER SER ILE LYS ARG SER VAL ILE GLY SER          
SEQRES  30 I  452  SER CYS LEU ILE LYS ASP ARG VAL THR ILE THR ASN CYS          
SEQRES  31 I  452  LEU LEU MET ASN SER VAL THR VAL GLU GLU GLY SER ASN          
SEQRES  32 I  452  ILE GLN GLY SER VAL ILE CYS ASN ASN ALA VAL ILE GLU          
SEQRES  33 I  452  LYS GLY ALA ASP ILE LYS ASP CYS LEU ILE GLY SER GLY          
SEQRES  34 I  452  GLN ARG ILE GLU ALA LYS ALA LYS ARG VAL ASN GLU VAL          
SEQRES  35 I  452  ILE VAL GLY ASN ASP GLN LEU MET GLU ILE                      
SEQRES   1 J  452  MET GLU PHE GLN ALA VAL VAL MET ALA VAL GLY GLY GLY          
SEQRES   2 J  452  SER ARG MET THR ASP LEU THR SER SER ILE PRO LYS PRO          
SEQRES   3 J  452  LEU LEU PRO VAL GLY ASN LYS PRO LEU ILE TRP TYR PRO          
SEQRES   4 J  452  LEU ASN LEU LEU GLU ARG VAL GLY PHE GLU GLU VAL ILE          
SEQRES   5 J  452  VAL VAL THR THR ARG ASP VAL GLN LYS ALA LEU CYS ALA          
SEQRES   6 J  452  GLU PHE LYS MET LYS MET LYS PRO ASP ILE VAL CYS ILE          
SEQRES   7 J  452  PRO ASP ASP ALA ASP MET GLY THR ALA ASP SER LEU ARG          
SEQRES   8 J  452  TYR ILE TYR PRO LYS LEU LYS THR ASP VAL LEU VAL LEU          
SEQRES   9 J  452  SER CYS ASP LEU ILE THR ASP VAL ALA LEU HIS GLU VAL          
SEQRES  10 J  452  VAL ASP LEU PHE ARG ALA TYR ASP ALA SER LEU ALA MET          
SEQRES  11 J  452  LEU MET ARG LYS GLY GLN ASP SER ILE GLU PRO VAL PRO          
SEQRES  12 J  452  GLY GLN LYS GLY LYS LYS LYS ALA VAL GLU GLN ARG ASP          
SEQRES  13 J  452  PHE ILE GLY VAL ASP SER THR GLY LYS ARG LEU LEU PHE          
SEQRES  14 J  452  MET ALA ASN GLU ALA ASP LEU ASP GLU GLU LEU VAL ILE          
SEQRES  15 J  452  LYS GLY SER ILE LEU GLN LYS HIS PRO ARG ILE ARG PHE          
SEQRES  16 J  452  HIS THR GLY LEU VAL ASP ALA HIS LEU TYR CYS LEU LYS          
SEQRES  17 J  452  LYS TYR ILE VAL ASP PHE LEU MET GLU ASN GLY SER ILE          
SEQRES  18 J  452  THR SER ILE ARG SER GLU LEU ILE PRO TYR LEU VAL ARG          
SEQRES  19 J  452  LYS GLN PHE SER SER ALA SER SER GLN GLN GLY GLN GLU          
SEQRES  20 J  452  GLU LYS GLU GLU ASP LEU LYS LYS LYS GLU LEU LYS SER          
SEQRES  21 J  452  LEU ASP ILE TYR SER PHE ILE LYS GLU ALA ASN THR LEU          
SEQRES  22 J  452  ASN LEU ALA PRO TYR ASP ALA CYS TRP ASN ALA CYS ARG          
SEQRES  23 J  452  GLY ASP ARG TRP GLU ASP LEU SER ARG SER GLN VAL ARG          
SEQRES  24 J  452  CYS TYR VAL HIS ILE MET LYS GLU GLY LEU CYS SER ARG          
SEQRES  25 J  452  VAL SER THR LEU GLY LEU TYR MET GLU ALA ASN ARG GLN          
SEQRES  26 J  452  VAL PRO LYS LEU LEU SER ALA LEU CYS PRO GLU GLU PRO          
SEQRES  27 J  452  PRO VAL HIS SER SER ALA GLN ILE VAL SER LYS HIS LEU          
SEQRES  28 J  452  VAL GLY VAL ASP SER LEU ILE GLY PRO GLU THR GLN ILE          
SEQRES  29 J  452  GLY GLU LYS SER SER ILE LYS ARG SER VAL ILE GLY SER          
SEQRES  30 J  452  SER CYS LEU ILE LYS ASP ARG VAL THR ILE THR ASN CYS          
SEQRES  31 J  452  LEU LEU MET ASN SER VAL THR VAL GLU GLU GLY SER ASN          
SEQRES  32 J  452  ILE GLN GLY SER VAL ILE CYS ASN ASN ALA VAL ILE GLU          
SEQRES  33 J  452  LYS GLY ALA ASP ILE LYS ASP CYS LEU ILE GLY SER GLY          
SEQRES  34 J  452  GLN ARG ILE GLU ALA LYS ALA LYS ARG VAL ASN GLU VAL          
SEQRES  35 J  452  ILE VAL GLY ASN ASP GLN LEU MET GLU ILE                      
SEQRES   1 L  314  PRO GLY LEU SER CYS ARG PHE TYR GLN HIS LYS PHE PRO          
SEQRES   2 L  314  GLU VAL GLU ASP VAL VAL MET VAL ASN VAL ARG SER ILE          
SEQRES   3 L  314  ALA GLU MET GLY ALA TYR VAL SER LEU LEU GLU TYR ASN          
SEQRES   4 L  314  ASN ILE GLU GLY MET ILE LEU LEU SER GLU LEU SER ARG          
SEQRES   5 L  314  ARG ARG ILE ARG SER ILE ASN LYS LEU ILE ARG ILE GLY          
SEQRES   6 L  314  ARG ASN GLU CYS VAL VAL VAL ILE ARG VAL ASP LYS GLU          
SEQRES   7 L  314  LYS GLY TYR ILE ASP LEU SER LYS ARG ARG VAL SER PRO          
SEQRES   8 L  314  GLU GLU ALA ILE LYS CYS GLU ASP LYS PHE THR LYS SER          
SEQRES   9 L  314  LYS THR VAL TYR SER ILE LEU ARG HIS VAL ALA GLU VAL          
SEQRES  10 L  314  LEU GLU TYR THR LYS ASP GLU GLN LEU GLU SER LEU PHE          
SEQRES  11 L  314  GLN ARG THR ALA TRP VAL PHE ASP ASP LYS TYR LYS ARG          
SEQRES  12 L  314  PRO GLY TYR GLY ALA TYR ASP ALA PHE LYS HIS ALA VAL          
SEQRES  13 L  314  SER ASP PRO SER ILE LEU ASP SER LEU ASP LEU ASN GLU          
SEQRES  14 L  314  ASP GLU ARG GLU VAL LEU ILE ASN ASN ILE ASN ARG ARG          
SEQRES  15 L  314  LEU THR PRO GLN ALA VAL LYS ILE ARG ALA ASP ILE GLU          
SEQRES  16 L  314  VAL ALA CYS TYR GLY TYR GLU GLY ILE ASP ALA VAL LYS          
SEQRES  17 L  314  GLU ALA LEU ARG ALA GLY LEU ASN CYS SER THR GLU ASN          
SEQRES  18 L  314  MET PRO ILE LYS ILE ASN LEU ILE ALA PRO PRO ARG TYR          
SEQRES  19 L  314  VAL MET THR THR THR THR LEU GLU ARG THR GLU GLY LEU          
SEQRES  20 L  314  SER VAL LEU SER GLN ALA MET ALA VAL ILE LYS GLU LYS          
SEQRES  21 L  314  ILE GLU GLU LYS ARG GLY VAL PHE ASN VAL GLN MET GLU          
SEQRES  22 L  314  PRO LYS VAL VAL THR ASP THR ASP GLU THR GLU LEU ALA          
SEQRES  23 L  314  ARG GLN MET GLU ARG LEU GLU ARG GLU ASN ALA GLU VAL          
SEQRES  24 L  314  ASP GLY ASP ASP ASP ALA GLU GLU MET GLU ALA LYS ALA          
SEQRES  25 L  314  GLU ASP                                                      
SEQRES   1 S  472  MET ALA GLY GLY GLU ALA GLY VAL THR LEU GLY GLN PRO          
SEQRES   2 S  472  HIS LEU SER ARG GLN ASP LEU THR THR LEU ASP VAL THR          
SEQRES   3 S  472  LYS LEU THR PRO LEU SER HIS GLU VAL ILE SER ARG GLN          
SEQRES   4 S  472  ALA THR ILE ASN ILE GLY THR ILE GLY HIS VAL ALA HIS          
SEQRES   5 S  472  GLY LYS SER THR VAL VAL LYS ALA ILE SER GLY VAL HIS          
SEQRES   6 S  472  THR VAL ARG PHE LYS ASN GLU LEU GLU ARG ASN ILE THR          
SEQRES   7 S  472  ILE LYS LEU GLY TYR ALA ASN ALA LYS ILE TYR LYS LEU          
SEQRES   8 S  472  ASP ASP PRO SER CYS PRO ARG PRO GLU CYS TYR ARG SER          
SEQRES   9 S  472  CYS GLY SER SER THR PRO ASP GLU PHE PRO THR ASP ILE          
SEQRES  10 S  472  PRO GLY THR LYS GLY ASN PHE LYS LEU VAL ARG HIS VAL          
SEQRES  11 S  472  SER PHE VAL ASP CYS PRO GLY HIS ASP ILE LEU MET ALA          
SEQRES  12 S  472  THR MET LEU ASN GLY ALA ALA VAL MET ASP ALA ALA LEU          
SEQRES  13 S  472  LEU LEU ILE ALA GLY ASN GLU SER CYS PRO GLN PRO GLN          
SEQRES  14 S  472  THR SER GLU HIS LEU ALA ALA ILE GLU ILE MET LYS LEU          
SEQRES  15 S  472  LYS HIS ILE LEU ILE LEU GLN ASN LYS ILE ASP LEU VAL          
SEQRES  16 S  472  LYS GLU SER GLN ALA LYS GLU GLN TYR GLU GLN ILE LEU          
SEQRES  17 S  472  ALA PHE VAL GLN GLY THR VAL ALA GLU GLY ALA PRO ILE          
SEQRES  18 S  472  ILE PRO ILE SER ALA GLN LEU LYS TYR ASN ILE GLU VAL          
SEQRES  19 S  472  VAL CYS GLU TYR ILE VAL LYS LYS ILE PRO VAL PRO PRO          
SEQRES  20 S  472  ARG ASP PHE THR SER GLU PRO ARG LEU ILE VAL ILE ARG          
SEQRES  21 S  472  SER PHE ASP VAL ASN LYS PRO GLY CYS GLU VAL ASP ASP          
SEQRES  22 S  472  LEU LYS GLY GLY VAL ALA GLY GLY SER ILE LEU LYS GLY          
SEQRES  23 S  472  VAL LEU LYS VAL GLY GLN GLU ILE GLU VAL ARG PRO GLY          
SEQRES  24 S  472  ILE VAL SER LYS ASP SER GLU GLY LYS LEU MET CYS LYS          
SEQRES  25 S  472  PRO ILE PHE SER LYS ILE VAL SER LEU PHE ALA GLU HIS          
SEQRES  26 S  472  ASN ASP LEU GLN TYR ALA ALA PRO GLY GLY LEU ILE GLY          
SEQRES  27 S  472  VAL GLY THR LYS ILE ASP PRO THR LEU CYS ARG ALA ASP          
SEQRES  28 S  472  ARG MET VAL GLY GLN VAL LEU GLY ALA VAL GLY ALA LEU          
SEQRES  29 S  472  PRO GLU ILE PHE THR GLU LEU GLU ILE SER TYR PHE LEU          
SEQRES  30 S  472  LEU ARG ARG LEU LEU GLY VAL ARG THR GLU GLY ASP LYS          
SEQRES  31 S  472  LYS ALA ALA LYS VAL GLN LYS LEU SER LYS ASN GLU VAL          
SEQRES  32 S  472  LEU MET VAL ASN ILE GLY SER LEU SER THR GLY GLY ARG          
SEQRES  33 S  472  VAL SER ALA VAL LYS ALA ASP LEU GLY LYS ILE VAL LEU          
SEQRES  34 S  472  THR ASN PRO VAL CYS THR GLU VAL GLY GLU LYS ILE ALA          
SEQRES  35 S  472  LEU SER ARG ARG VAL GLU LYS HIS TRP ARG LEU ILE GLY          
SEQRES  36 S  472  TRP GLY GLN ILE ARG ARG GLY VAL THR ILE LYS PRO THR          
SEQRES  37 S  472  VAL ASP ASP ASP                                              
SEQRES   1 d   14  UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK UNK          
SEQRES   2 d   14  UNK                                                          
HET    C7B  C 401      60                                                       
HETNAM     C7B 2-(4-CHLORANYLPHENOXY)-~{N}-[4-[2-(4-CHLORANYLPHENOXY)           
HETNAM   2 C7B  ETHANOYLAMINO]CYCLOHEXYL]ETHANAMIDE                             
HETSYN     C7B ISRIB                                                            
FORMUL  14  C7B    C22 H24 CL2 N2 O4                                            
HELIX    1 AA1 PRO A   64  LEU A   68  5                                   5    
HELIX    2 AA2 ALA A   74  GLY A   87  1                                  14    
HELIX    3 AA3 LYS A   98  LYS A  108  1                                  11    
HELIX    4 AA4 SER A  109  ARG A  113  5                                   5    
HELIX    5 AA5 SER A  130  ALA A  142  1                                  13    
HELIX    6 AA6 ILE A  161  GLU A  175  1                                  15    
HELIX    7 AA7 LEU A  228  SER A  234  1                                   7    
HELIX    8 AA8 SER A  253  ASN A  263  1                                  11    
HELIX    9 AA9 THR A  268  VAL A  278  1                                  11    
HELIX   10 AB1 ASN A  302  ARG A  315  1                                  14    
HELIX   11 AB2 SER A  330  SER A  334  5                                   5    
HELIX   12 AB3 ARG A  339  ASN A  341  5                                   3    
HELIX   13 AB4 PRO B   64  LEU B   68  5                                   5    
HELIX   14 AB5 ALA B   74  GLY B   87  1                                  14    
HELIX   15 AB6 LYS B   98  LEU B  107  1                                  10    
HELIX   16 AB7 SER B  130  ALA B  142  1                                  13    
HELIX   17 AB8 ILE B  161  GLU B  175  1                                  15    
HELIX   18 AB9 LEU B  228  SER B  234  1                                   7    
HELIX   19 AC1 PRO B  254  ASN B  263  1                                  10    
HELIX   20 AC2 THR B  268  VAL B  278  1                                  11    
HELIX   21 AC3 ASN B  302  ARG B  315  1                                  14    
HELIX   22 AC4 ARG B  339  ASN B  341  5                                   3    
HELIX   23 AC5 ILE B  550  ASN B  568  1                                  19    
HELIX   24 AC6 SER B  570  ASN B  586  1                                  17    
HELIX   25 AC7 SER B  588  GLN B  606  1                                  19    
HELIX   26 AC8 ASP B  613  TRP B  628  1                                  16    
HELIX   27 AC9 TRP B  628  ILE B  636  1                                   9    
HELIX   28 AD1 ARG B  638  HIS B  656  1                                  19    
HELIX   29 AD2 GLU B  657  ILE B  661  5                                   5    
HELIX   30 AD3 SER B  662  TYR B  671  1                                  10    
HELIX   31 AD4 ALA B  677  GLN B  687  1                                  11    
HELIX   32 AD5 LYS B  693  LYS B  699  1                                   7    
HELIX   33 AD6 ASN B  700  GLU B  715  1                                  16    
HELIX   34 AD7 SER C    9  GLY C   25  1                                  17    
HELIX   35 AD8 SER C   30  THR C   47  1                                  18    
HELIX   36 AD9 ASN C   53  GLN C   72  1                                  20    
HELIX   37 AE1 THR C   76  GLY C   98  1                                  23    
HELIX   38 AE2 GLN C  128  GLY C  146  1                                  19    
HELIX   39 AE3 THR C  147  GLN C  154  1                                   8    
HELIX   40 AE4 ALA C  155  ILE C  159  5                                   5    
HELIX   41 AE5 SER C  171  ALA C  182  1                                  12    
HELIX   42 AE6 GLN C  199  SER C  208  1                                  10    
HELIX   43 AE7 ALA C  221  MET C  226  1                                   6    
HELIX   44 AE8 GLY C  250  HIS C  261  1                                  12    
HELIX   45 AE9 GLY C  300  GLU C  304  5                                   5    
HELIX   46 AF1 PRO C  317  ILE C  321  5                                   5    
HELIX   47 AF2 ALA C  332  SER C  334  5                                   3    
HELIX   48 AF3 TYR C  335  TYR C  344  1                                  10    
HELIX   49 AF4 HIS C  345  HIS C  349  5                                   5    
HELIX   50 AF5 SER D    9  GLY D   25  1                                  17    
HELIX   51 AF6 SER D   30  THR D   47  1                                  18    
HELIX   52 AF7 ASN D   53  GLN D   72  1                                  20    
HELIX   53 AF8 THR D   76  GLY D   98  1                                  23    
HELIX   54 AF9 TYR D  126  GLU D  145  1                                  20    
HELIX   55 AG1 GLY D  146  GLN D  154  1                                   9    
HELIX   56 AG2 ALA D  155  HIS D  158  5                                   4    
HELIX   57 AG3 SER D  171  ALA D  182  1                                  12    
HELIX   58 AG4 GLN D  199  SER D  208  1                                  10    
HELIX   59 AG5 THR D  218  ALA D  220  5                                   3    
HELIX   60 AG6 ALA D  221  MET D  226  1                                   6    
HELIX   61 AG7 GLY D  250  HIS D  261  1                                  12    
HELIX   62 AG8 PRO D  296  GLU D  304  5                                   9    
HELIX   63 AG9 PRO D  317  ILE D  321  5                                   5    
HELIX   64 AH1 TYR D  335  TYR D  344  1                                  10    
HELIX   65 AH2 SER E  191  MET E  196  5                                   6    
HELIX   66 AH3 HIS E  204  GLN E  216  1                                  13    
HELIX   67 AH4 GLY E  221  ASP E  239  1                                  19    
HELIX   68 AH5 GLU E  247  ARG E  267  1                                  21    
HELIX   69 AH6 SER E  270  SER E  286  1                                  17    
HELIX   70 AH7 ARG E  292  GLN E  325  1                                  34    
HELIX   71 AH8 SER E  339  GLY E  353  1                                  15    
HELIX   72 AH9 GLU E  368  HIS E  378  1                                  11    
HELIX   73 AI1 ALA E  390  LEU E  395  1                                   6    
HELIX   74 AI2 THR E  420  HIS E  430  1                                  11    
HELIX   75 AI3 GLU E  439  PHE E  443  5                                   5    
HELIX   76 AI4 ASP E  459  LEU E  463  5                                   5    
HELIX   77 AI5 ASN E  475  HIS E  479  5                                   5    
HELIX   78 AI6 PRO E  508  SER E  510  5                                   3    
HELIX   79 AI7 SER E  511  VAL E  518  1                                   8    
HELIX   80 AI8 SER F  191  MET F  196  5                                   6    
HELIX   81 AI9 HIS F  204  GLN F  216  1                                  13    
HELIX   82 AJ1 GLY F  221  ASP F  239  1                                  19    
HELIX   83 AJ2 GLU F  247  ARG F  267  1                                  21    
HELIX   84 AJ3 SER F  270  THR F  285  1                                  16    
HELIX   85 AJ4 ARG F  292  GLN F  325  1                                  34    
HELIX   86 AJ5 SER F  339  GLY F  353  1                                  15    
HELIX   87 AJ6 GLU F  368  HIS F  378  1                                  11    
HELIX   88 AJ7 ALA F  390  LEU F  395  1                                   6    
HELIX   89 AJ8 THR F  420  HIS F  430  1                                  11    
HELIX   90 AJ9 GLU F  439  PHE F  443  5                                   5    
HELIX   91 AK1 ASP F  459  LEU F  463  5                                   5    
HELIX   92 AK2 PRO F  508  SER F  510  5                                   3    
HELIX   93 AK3 SER F  511  SER F  520  1                                  10    
HELIX   94 AK4 GLU G    5  GLU G   16  1                                  12    
HELIX   95 AK5 ALA G   21  LYS G   38  1                                  18    
HELIX   96 AK6 ILE G   42  ASP G   60  1                                  19    
HELIX   97 AK7 SER G   62  TYR G   83  1                                  22    
HELIX   98 AK8 ASP G   85  SER G  105  1                                  21    
HELIX   99 AK9 LEU G  106  HIS G  116  1                                  11    
HELIX  100 AL1 SER G  131  ALA G  144  1                                  14    
HELIX  101 AL2 SER G  160  HIS G  170  1                                  11    
HELIX  102 AL3 THR G  212  GLN G  222  1                                  11    
HELIX  103 AL4 PRO G  247  LYS G  251  5                                   5    
HELIX  104 AL5 ALA G  277  ILE G  281  5                                   5    
HELIX  105 AL6 SER G  294  TYR G  304  1                                  11    
HELIX  106 AL7 GLU H    5  GLU H   16  1                                  12    
HELIX  107 AL8 ALA H   21  LYS H   38  1                                  18    
HELIX  108 AL9 ILE H   42  ASP H   60  1                                  19    
HELIX  109 AM1 SER H   62  TYR H   83  1                                  22    
HELIX  110 AM2 ASP H   85  SER H  105  1                                  21    
HELIX  111 AM3 LEU H  106  HIS H  116  1                                  11    
HELIX  112 AM4 SER H  131  ALA H  144  1                                  14    
HELIX  113 AM5 SER H  160  HIS H  170  1                                  11    
HELIX  114 AM6 THR H  212  GLN H  222  1                                  11    
HELIX  115 AM7 PRO H  247  LYS H  251  5                                   5    
HELIX  116 AM8 ALA H  277  ILE H  281  5                                   5    
HELIX  117 AM9 SER H  294  TYR H  304  1                                  11    
HELIX  118 AN1 ILE I   36  VAL I   46  1                                  11    
HELIX  119 AN2 ALA I   62  LYS I   68  1                                   7    
HELIX  120 AN3 GLY I   85  ILE I   93  1                                   9    
HELIX  121 AN4 TYR I   94  LEU I   97  5                                   4    
HELIX  122 AN5 LEU I  114  TYR I  124  1                                  11    
HELIX  123 AN6 LYS I  183  HIS I  190  1                                   8    
HELIX  124 AN7 LYS I  208  ASN I  218  1                                  11    
HELIX  125 AN8 SER I  223  LEU I  228  1                                   6    
HELIX  126 AN9 ILE I  229  GLN I  236  1                                   8    
HELIX  127 AO1 TRP I  282  ASP I  292  1                                  11    
HELIX  128 AO2 ILE J   36  VAL J   46  1                                  11    
HELIX  129 AO3 ALA J   62  LYS J   68  1                                   7    
HELIX  130 AO4 GLY J   85  ILE J   93  1                                   9    
HELIX  131 AO5 TYR J   94  LEU J   97  5                                   4    
HELIX  132 AO6 LEU J  114  TYR J  124  1                                  11    
HELIX  133 AO7 LYS J  183  HIS J  190  1                                   8    
HELIX  134 AO8 LYS J  208  ASN J  218  1                                  11    
HELIX  135 AO9 SER J  223  LEU J  228  1                                   6    
HELIX  136 AP1 ILE J  229  GLN J  236  1                                   8    
HELIX  137 AP2 TRP J  282  ASP J  292  1                                  11    
HELIX  138 AP3 SER L   57  LEU L   61  5                                   5    
HELIX  139 AP4 SER L   90  GLU L  119  1                                  30    
HELIX  140 AP5 LYS L  122  ALA L  134  1                                  13    
HELIX  141 AP6 ALA L  134  LYS L  142  1                                   9    
HELIX  142 AP7 GLY L  145  ASP L  158  1                                  14    
HELIX  143 AP8 ILE L  161  LEU L  165  5                                   5    
HELIX  144 AP9 ASN L  168  LEU L  183  1                                  16    
HELIX  145 AQ1 GLU L  202  CYS L  217  1                                  16    
HELIX  146 AQ2 GLU L  242  LYS L  264  1                                  23    
HELIX  147 AQ3 GLY S   53  SER S   62  1                                  10    
HELIX  148 AQ4 GLY S  137  LEU S  146  1                                  10    
HELIX  149 AQ5 CYS S  165  ILE S  179  1                                  15    
HELIX  150 AQ6 VAL S  195  THR S  214  1                                  20    
HELIX  151 AQ7 LYS S  229  ILE S  243  1                                  15    
HELIX  152 AQ8 UNK d    4  UNK d   16  1                                  13    
SHEET    1 AA1 4 ILE A 122  THR A 124  0                                        
SHEET    2 AA1 4 GLU A  90  CYS A  95  1  N  VAL A  93   O  ILE A 123           
SHEET    3 AA1 4 GLN A  44  VAL A  48  1  N  LEU A  47   O  PHE A  92           
SHEET    4 AA1 4 LEU A 149  TYR A 152  1  O  VAL A 151   N  VAL A  46           
SHEET    1 AA2 2 VAL A 155  SER A 157  0                                        
SHEET    2 AA2 2 GLY A 297  ARG A 299 -1  O  ALA A 298   N  ILE A 156           
SHEET    1 AA3 3 LEU A 244  ASP A 246  0                                        
SHEET    2 AA3 3 MET A 181  GLU A 187 -1  N  LYS A 186   O  LEU A 245           
SHEET    3 AA3 3 ILE A 287  THR A 292  1  O  HIS A 290   N  MET A 183           
SHEET    1 AA4 6 ARG A 211  LYS A 217  0                                        
SHEET    2 AA4 6 VAL A 201  ASP A 206 -1  N  ALA A 204   O  LEU A 213           
SHEET    3 AA4 6 VAL A 238  ARG A 241 -1  O  ARG A 241   N  VAL A 203           
SHEET    4 AA4 6 ARG I 192  HIS I 196 -1  O  PHE I 195   N  VAL A 238           
SHEET    5 AA4 6 PHE I 157  ASP I 161 -1  N  VAL I 160   O  ARG I 194           
SHEET    6 AA4 6 LEU I 167  ALA I 171 -1  O  LEU I 168   N  GLY I 159           
SHEET    1 AA5 2 PHE A 224  ALA A 225  0                                        
SHEET    2 AA5 2 VAL I 181  ILE I 182 -1  O  ILE I 182   N  PHE A 224           
SHEET    1 AA6 3 THR A 336  HIS A 337  0                                        
SHEET    2 AA6 3 TYR A 343  ARG A 344 -1  O  ARG A 344   N  THR A 336           
SHEET    3 AA6 3 LEU A 361  LEU A 362  1  O  LEU A 362   N  TYR A 343           
SHEET    1 AA7 5 ILE A 355  LEU A 356  0                                        
SHEET    2 AA7 5 PHE A 373  THR A 375  1  O  ILE A 374   N  ILE A 355           
SHEET    3 AA7 5 VAL A 390  ASP A 392  1  O  LEU A 391   N  THR A 375           
SHEET    4 AA7 5 GLN A 407  HIS A 409  1  O  ILE A 408   N  VAL A 390           
SHEET    5 AA7 5 THR A 424  LEU A 425  1  O  LEU A 425   N  GLN A 407           
SHEET    1 AA8 2 VAL A 367  ILE A 368  0                                        
SHEET    2 AA8 2 HIS A 384  ILE A 385  1  O  ILE A 385   N  VAL A 367           
SHEET    1 AA9 2 VAL A 378  ILE A 379  0                                        
SHEET    2 AA9 2 TYR A 395  LEU A 396  1  O  LEU A 396   N  VAL A 378           
SHEET    1 AB1 3 SER A 411  LEU A 413  0                                        
SHEET    2 AB1 3 SER A 429  LEU A 431  1  O  LEU A 431   N  LEU A 412           
SHEET    3 AB1 3 SER A 447  ILE A 449  1  O  ILE A 449   N  VAL A 430           
SHEET    1 AB2 7 ILE B 122  THR B 124  0                                        
SHEET    2 AB2 7 GLU B  90  CYS B  95  1  N  VAL B  93   O  ILE B 123           
SHEET    3 AB2 7 GLN B  44  VAL B  48  1  N  LEU B  47   O  PHE B  92           
SHEET    4 AB2 7 PHE B 148  TYR B 152  1  O  LEU B 149   N  GLN B  44           
SHEET    5 AB2 7 ILE B 251  CYS B 252 -1  O  CYS B 252   N  PHE B 148           
SHEET    6 AB2 7 MET B 181  GLU B 187 -1  N  THR B 182   O  ILE B 251           
SHEET    7 AB2 7 LEU B 244  ASP B 246 -1  O  LEU B 245   N  LYS B 186           
SHEET    1 AB3 7 ILE B 122  THR B 124  0                                        
SHEET    2 AB3 7 GLU B  90  CYS B  95  1  N  VAL B  93   O  ILE B 123           
SHEET    3 AB3 7 GLN B  44  VAL B  48  1  N  LEU B  47   O  PHE B  92           
SHEET    4 AB3 7 PHE B 148  TYR B 152  1  O  LEU B 149   N  GLN B  44           
SHEET    5 AB3 7 ILE B 251  CYS B 252 -1  O  CYS B 252   N  PHE B 148           
SHEET    6 AB3 7 MET B 181  GLU B 187 -1  N  THR B 182   O  ILE B 251           
SHEET    7 AB3 7 HIS B 288  THR B 292  1  O  HIS B 288   N  MET B 181           
SHEET    1 AB4 2 VAL B 155  SER B 157  0                                        
SHEET    2 AB4 2 GLY B 297  ARG B 299 -1  O  ALA B 298   N  ILE B 156           
SHEET    1 AB5 6 VAL B 212  LYS B 217  0                                        
SHEET    2 AB5 6 VAL B 201  VAL B 205 -1  N  ALA B 204   O  HIS B 214           
SHEET    3 AB5 6 VAL B 238  ARG B 241 -1  O  ARG B 241   N  VAL B 203           
SHEET    4 AB5 6 ARG J 192  HIS J 196 -1  O  ILE J 193   N  VAL B 240           
SHEET    5 AB5 6 PHE J 157  ASP J 161 -1  N  VAL J 160   O  ARG J 194           
SHEET    6 AB5 6 LEU J 167  ALA J 171 -1  O  LEU J 168   N  GLY J 159           
SHEET    1 AB6 2 PHE B 224  ALA B 225  0                                        
SHEET    2 AB6 2 VAL J 181  ILE J 182 -1  O  ILE J 182   N  PHE B 224           
SHEET    1 AB7 8 THR B 336  HIS B 337  0                                        
SHEET    2 AB7 8 TYR B 343  ARG B 344 -1  O  ARG B 344   N  THR B 336           
SHEET    3 AB7 8 LEU B 361  LEU B 362  1  O  LEU B 362   N  TYR B 343           
SHEET    4 AB7 8 VAL B 378  ILE B 379  1  O  ILE B 379   N  LEU B 361           
SHEET    5 AB7 8 TYR B 395  LEU B 396  1  O  LEU B 396   N  VAL B 378           
SHEET    6 AB7 8 LEU B 412  LEU B 413  1  O  LEU B 413   N  TYR B 395           
SHEET    7 AB7 8 SER B 429  LEU B 431  1  O  LEU B 431   N  LEU B 412           
SHEET    8 AB7 8 SER B 447  ILE B 449  1  O  SER B 447   N  VAL B 430           
SHEET    1 AB8 4 ILE B 355  LEU B 356  0                                        
SHEET    2 AB8 4 PHE B 373  THR B 375  1  O  ILE B 374   N  ILE B 355           
SHEET    3 AB8 4 VAL B 390  ASP B 392  1  O  LEU B 391   N  THR B 375           
SHEET    4 AB8 4 GLN B 407  HIS B 409  1  O  ILE B 408   N  VAL B 390           
SHEET    1 AB9 2 GLU B 418  VAL B 419  0                                        
SHEET    2 AB9 2 VAL B 436  VAL B 437  1  O  VAL B 437   N  GLU B 418           
SHEET    1 AC1 8 GLY C 329  ASN C 331  0                                        
SHEET    2 AC1 8 LEU C 323  SER C 326 -1  N  PHE C 324   O  ASN C 331           
SHEET    3 AC1 8 LEU C 265  CYS C 268  1  N  VAL C 267   O  ILE C 325           
SHEET    4 AC1 8 LYS C 231  ILE C 234  1  N  VAL C 232   O  ILE C 266           
SHEET    5 AC1 8 VAL C 164  ILE C 168  1  N  VAL C 164   O  LYS C 231           
SHEET    6 AC1 8 HIS C 188  ALA C 192  1  O  ILE C 190   N  ILE C 165           
SHEET    7 AC1 8 THR C 214  MET C 217  1  O  THR C 215   N  VAL C 189           
SHEET    8 AC1 8 LEU F 482  LEU F 484  1  O  ARG F 483   N  THR C 214           
SHEET    1 AC2 3 THR C 238  ILE C 239  0                                        
SHEET    2 AC2 3 LEU C 245  VAL C 248 -1  O  ARG C 246   N  THR C 238           
SHEET    3 AC2 3 PHE C 313  VAL C 316 -1  O  VAL C 316   N  LEU C 245           
SHEET    1 AC3 8 GLY D 329  ASN D 331  0                                        
SHEET    2 AC3 8 LEU D 323  SER D 326 -1  N  SER D 326   O  GLY D 329           
SHEET    3 AC3 8 LEU D 265  CYS D 268  1  N  VAL D 267   O  ILE D 325           
SHEET    4 AC3 8 LYS D 231  ILE D 234  1  N  ILE D 234   O  ILE D 266           
SHEET    5 AC3 8 VAL D 164  ILE D 168  1  N  VAL D 164   O  LYS D 231           
SHEET    6 AC3 8 HIS D 188  ALA D 192  1  O  ILE D 190   N  ILE D 165           
SHEET    7 AC3 8 THR D 214  MET D 217  1  O  THR D 215   N  VAL D 189           
SHEET    8 AC3 8 LEU E 482  LEU E 484  1  O  ARG E 483   N  VAL D 216           
SHEET    1 AC4 3 THR D 238  ILE D 239  0                                        
SHEET    2 AC4 3 LEU D 245  VAL D 248 -1  O  ARG D 246   N  THR D 238           
SHEET    3 AC4 3 PHE D 313  VAL D 316 -1  O  VAL D 316   N  LEU D 245           
SHEET    1 AC5 7 ALA E 383  LEU E 387  0                                        
SHEET    2 AC5 7 ARG E 357  ASP E 362  1  N  VAL E 360   O  SER E 384           
SHEET    3 AC5 7 VAL E 332  TYR E 336  1  N  ILE E 333   O  VAL E 359           
SHEET    4 AC5 7 LYS E 400  GLY E 404  1  O  LEU E 402   N  LEU E 334           
SHEET    5 AC5 7 VAL E 434  CYS E 437  1  O  LEU E 435   N  LEU E 403           
SHEET    6 AC5 7 LEU E 499  THR E 502  1  O  LEU E 499   N  VAL E 434           
SHEET    7 AC5 7 GLY E 505  ILE E 507 -1  O  ILE E 507   N  VAL E 500           
SHEET    1 AC6 3 ALA E 407  LEU E 408  0                                        
SHEET    2 AC6 3 VAL E 414  ARG E 417 -1  O  MET E 415   N  ALA E 407           
SHEET    3 AC6 3 TYR E 489  ASP E 490 -1  O  ASP E 490   N  SER E 416           
SHEET    1 AC7 7 ALA F 383  LEU F 387  0                                        
SHEET    2 AC7 7 PHE F 356  ASP F 362  1  N  VAL F 360   O  SER F 384           
SHEET    3 AC7 7 ASP F 331  TYR F 336  1  N  ILE F 333   O  VAL F 359           
SHEET    4 AC7 7 LYS F 400  GLY F 404  1  O  LEU F 402   N  LEU F 334           
SHEET    5 AC7 7 VAL F 434  CYS F 437  1  O  LEU F 435   N  LEU F 403           
SHEET    6 AC7 7 LEU F 499  THR F 502  1  O  ILE F 501   N  VAL F 436           
SHEET    7 AC7 7 GLY F 505  ILE F 507 -1  O  ILE F 507   N  VAL F 500           
SHEET    1 AC8 3 ALA F 407  LEU F 408  0                                        
SHEET    2 AC8 3 VAL F 414  ARG F 417 -1  O  MET F 415   N  ALA F 407           
SHEET    3 AC8 3 TYR F 489  THR F 492 -1  O  ASP F 490   N  SER F 416           
SHEET    1 AC9 7 VAL G 175  VAL G 178  0                                        
SHEET    2 AC9 7 PHE G 148  THR G 153  1  N  VAL G 152   O  VAL G 178           
SHEET    3 AC9 7 ALA G 123  THR G 127  1  N  ILE G 125   O  SER G 149           
SHEET    4 AC9 7 LEU G 192  GLY G 196  1  O  LEU G 192   N  THR G 124           
SHEET    5 AC9 7 PHE G 226  VAL G 229  1  O  VAL G 229   N  VAL G 195           
SHEET    6 AC9 7 LEU G 283  THR G 286  1  O  LEU G 283   N  VAL G 228           
SHEET    7 AC9 7 GLY G 289  LEU G 291 -1  O  LEU G 291   N  LEU G 284           
SHEET    1 AD1 3 GLY G 199  VAL G 200  0                                        
SHEET    2 AD1 3 ILE G 206  LYS G 209 -1  O  ILE G 207   N  GLY G 199           
SHEET    3 AD1 3 VAL G 273  THR G 276 -1  O  THR G 276   N  ILE G 206           
SHEET    1 AD2 7 VAL H 175  VAL H 178  0                                        
SHEET    2 AD2 7 PHE H 148  THR H 153  1  N  VAL H 152   O  VAL H 178           
SHEET    3 AD2 7 ALA H 123  THR H 127  1  N  ILE H 125   O  SER H 149           
SHEET    4 AD2 7 LEU H 192  GLY H 196  1  O  LEU H 192   N  THR H 124           
SHEET    5 AD2 7 PHE H 226  VAL H 229  1  O  VAL H 229   N  VAL H 195           
SHEET    6 AD2 7 LEU H 283  THR H 286  1  O  LEU H 283   N  VAL H 228           
SHEET    7 AD2 7 GLY H 289  LEU H 291 -1  O  LEU H 291   N  LEU H 284           
SHEET    1 AD3 3 GLY H 199  VAL H 200  0                                        
SHEET    2 AD3 3 ILE H 206  LYS H 209 -1  O  ILE H 207   N  GLY H 199           
SHEET    3 AD3 3 VAL H 273  THR H 276 -1  O  THR H 276   N  ILE H 206           
SHEET    1 AD4 4 ILE I  75  ILE I  78  0                                        
SHEET    2 AD4 4 VAL I  51  VAL I  54  1  N  VAL I  53   O  VAL I  76           
SHEET    3 AD4 4 PHE I   3  MET I   8  1  N  VAL I   7   O  VAL I  54           
SHEET    4 AD4 4 ASP I 100  SER I 105  1  O  LEU I 104   N  VAL I   6           
SHEET    1 AD5 3 VAL I 200  ASP I 201  0                                        
SHEET    2 AD5 3 LEU I 128  ARG I 133 -1  N  ARG I 133   O  VAL I 200           
SHEET    3 AD5 3 ILE I 263  LYS I 268  1  O  LYS I 268   N  MET I 132           
SHEET    1 AD6 4 ILE J  75  ILE J  78  0                                        
SHEET    2 AD6 4 VAL J  51  VAL J  54  1  N  VAL J  53   O  VAL J  76           
SHEET    3 AD6 4 PHE J   3  MET J   8  1  N  VAL J   7   O  VAL J  54           
SHEET    4 AD6 4 ASP J 100  SER J 105  1  O  LEU J 104   N  VAL J   6           
SHEET    1 AD7 3 VAL J 200  ASP J 201  0                                        
SHEET    2 AD7 3 LEU J 128  ARG J 133 -1  N  ARG J 133   O  VAL J 200           
SHEET    3 AD7 3 ILE J 263  LYS J 268  1  O  LYS J 268   N  MET J 132           
SHEET    1 AD8 6 VAL L  18  ILE L  26  0                                        
SHEET    2 AD8 6 GLY L  30  LEU L  35 -1  O  TYR L  32   N  ARG L  24           
SHEET    3 AD8 6 GLU L  42  LEU L  46 -1  O  ILE L  45   N  ALA L  31           
SHEET    4 AD8 6 TYR L  81  SER L  85  1  O  LEU L  84   N  MET L  44           
SHEET    5 AD8 6 ASN L  67  ASP L  76 -1  N  VAL L  71   O  SER L  85           
SHEET    6 AD8 6 VAL L  18  ILE L  26 -1  N  VAL L  21   O  GLU L  68           
SHEET    1 AD9 2 ILE L 190  ARG L 191  0                                        
SHEET    2 AD9 2 LYS L 275  VAL L 276 -1  O  LYS L 275   N  ARG L 191           
SHEET    1 AE1 4 ILE L 224  ASN L 227  0                                        
SHEET    2 AE1 4 TYR L 234  THR L 238 -1  O  VAL L 235   N  ASN L 227           
SHEET    3 AE1 4 ASP L 193  VAL L 196 -1  N  ILE L 194   O  TYR L 234           
SHEET    4 AE1 4 PHE L 268  ASN L 269 -1  O  ASN L 269   N  GLU L 195           
SHEET    1 AE2 3 ILE S  42  THR S  46  0                                        
SHEET    2 AE2 3 VAL S 130  ASP S 134  1  O  SER S 131   N  ILE S  44           
SHEET    3 AE2 3 GLY S  82  ALA S  86 -1  N  ALA S  84   O  PHE S 132           
SHEET    1 AE3 2 TYR S  89  LYS S  90  0                                        
SHEET    2 AE3 2 LYS S 125  LEU S 126 -1  O  LYS S 125   N  LYS S  90           
SHEET    1 AE4 2 ALA S 155  ILE S 159  0                                        
SHEET    2 AE4 2 ILE S 185  GLN S 189  1  O  LEU S 188   N  LEU S 157           
SHEET    1 AE5 7 LEU S 256  VAL S 258  0                                        
SHEET    2 AE5 7 VAL S 278  ILE S 283 -1  O  SER S 282   N  ILE S 257           
SHEET    3 AE5 7 LEU S 336  THR S 341 -1  O  ILE S 337   N  GLY S 281           
SHEET    4 AE5 7 PHE S 315  LEU S 321 -1  N  SER S 320   O  GLY S 340           
SHEET    5 AE5 7 GLU S 293  VAL S 296 -1  N  ILE S 294   O  SER S 316           
SHEET    6 AE5 7 VAL S 357  GLY S 359 -1  O  GLY S 359   N  GLU S 295           
SHEET    7 AE5 7 LEU S 256  VAL S 258 -1  N  LEU S 256   O  LEU S 358           
SHEET    1 AE6 2 ILE S 300  SER S 302  0                                        
SHEET    2 AE6 2 MET S 310  LYS S 312 -1  O  MET S 310   N  SER S 302           
SHEET    1 AE7 8 PHE S 376  LEU S 377  0                                        
SHEET    2 AE7 8 TRP S 451  ILE S 465 -1  O  TRP S 456   N  PHE S 376           
SHEET    3 AE7 8 LYS S 440  ARG S 446 -1  N  ARG S 445   O  ARG S 452           
SHEET    4 AE7 8 VAL S 403  ILE S 408 -1  N  MET S 405   O  SER S 444           
SHEET    5 AE7 8 LEU S 411  VAL S 420 -1  O  THR S 413   N  VAL S 406           
SHEET    6 AE7 8 GLY S 425  VAL S 433 -1  O  LYS S 426   N  ALA S 419           
SHEET    7 AE7 8 ILE S 367  ILE S 373 -1  N  PHE S 368   O  VAL S 433           
SHEET    8 AE7 8 TRP S 451  ILE S 465 -1  O  ARG S 461   N  GLU S 372           
CISPEP   1 PHE A   57    PRO A   58          0        -2.97                     
CISPEP   2 TYR A  319    PRO A  320          0         9.59                     
CISPEP   3 PHE B   57    PRO B   58          0        -3.84                     
CISPEP   4 TYR B  319    PRO B  320          0        13.35                     
CISPEP   5 GLY C   27    PRO C   28          0        -1.25                     
CISPEP   6 GLY D   27    PRO D   28          0        -1.26                     
CISPEP   7 ARG E  364    PRO E  365          0        -1.86                     
CISPEP   8 ARG F  364    PRO F  365          0        -2.50                     
SITE     1 AC1 18 ASN C 162  VAL C 164  HIS C 188  ILE C 190                    
SITE     2 AC1 18 THR C 215  ASN D 162  VAL D 164  HIS D 188                    
SITE     3 AC1 18 ILE D 190  THR D 215  VAL D 225  SER E 178                    
SITE     4 AC1 18 LEU E 179  LEU E 485  VAL F 177  SER F 178                    
SITE     5 AC1 18 LEU F 179  LEU F 485                                          
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1           1          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      1.000000  0.000000  0.000000        0.00000                         
SCALE2      0.000000  1.000000  0.000000        0.00000                         
SCALE3      0.000000  0.000000  1.000000        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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