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Database: PDB
Entry: 6O9Z
LinkDB: 6O9Z
Original site: 6O9Z 
HEADER    TRANSLATION                             15-MAR-19   6O9Z              
TITLE     ELECTRON CRYO-MICROSCOPY OF THE EUKARYOTIC TRANSLATION INITIATION     
TITLE    2 FACTOR 2B BOUND TO EUKARYOTIC TRANSLATION INITIATION FACTOR 2 FROM   
TITLE    3 HOMO SAPIENS                                                         
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON;      
COMPND   3 CHAIN: A, B;                                                         
COMPND   4 SYNONYM: EIF-2B GDP-GTP EXCHANGE FACTOR SUBUNIT EPSILON;             
COMPND   5 ENGINEERED: YES;                                                     
COMPND   6 MOL_ID: 2;                                                           
COMPND   7 MOLECULE: TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA;         
COMPND   8 CHAIN: C, D;                                                         
COMPND   9 SYNONYM: S20I15,S20III15,EIF-2B GDP-GTP EXCHANGE FACTOR SUBUNIT BETA;
COMPND  10 ENGINEERED: YES;                                                     
COMPND  11 MOL_ID: 3;                                                           
COMPND  12 MOLECULE: TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT DELTA;        
COMPND  13 CHAIN: E, F;                                                         
COMPND  14 SYNONYM: EIF-2B GDP-GTP EXCHANGE FACTOR SUBUNIT DELTA;               
COMPND  15 ENGINEERED: YES;                                                     
COMPND  16 MOL_ID: 4;                                                           
COMPND  17 MOLECULE: TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA;        
COMPND  18 CHAIN: G, H;                                                         
COMPND  19 SYNONYM: EIF-2B GDP-GTP EXCHANGE FACTOR SUBUNIT ALPHA;               
COMPND  20 ENGINEERED: YES;                                                     
COMPND  21 MOL_ID: 5;                                                           
COMPND  22 MOLECULE: TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA;        
COMPND  23 CHAIN: I, J;                                                         
COMPND  24 SYNONYM: EIF-2B GDP-GTP EXCHANGE FACTOR SUBUNIT GAMMA;               
COMPND  25 ENGINEERED: YES;                                                     
COMPND  26 MOL_ID: 6;                                                           
COMPND  27 MOLECULE: EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1;      
COMPND  28 CHAIN: L, M;                                                         
COMPND  29 SYNONYM: EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT ALPHA,   
COMPND  30 EIF-2ALPHA;                                                          
COMPND  31 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   3 ORGANISM_COMMON: HUMAN;                                              
SOURCE   4 ORGANISM_TAXID: 9606;                                                
SOURCE   5 GENE: EIF2B5, EIF2BE;                                                
SOURCE   6 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE   8 MOL_ID: 2;                                                           
SOURCE   9 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  10 ORGANISM_COMMON: HUMAN;                                              
SOURCE  11 ORGANISM_TAXID: 9606;                                                
SOURCE  12 GENE: EIF2B2, EIF2BB;                                                
SOURCE  13 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  14 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE  15 MOL_ID: 3;                                                           
SOURCE  16 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  17 ORGANISM_COMMON: HUMAN;                                              
SOURCE  18 ORGANISM_TAXID: 9606;                                                
SOURCE  19 GENE: EIF2B4, EIF2BD;                                                
SOURCE  20 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  21 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE  22 MOL_ID: 4;                                                           
SOURCE  23 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  24 ORGANISM_COMMON: HUMAN;                                              
SOURCE  25 ORGANISM_TAXID: 9606;                                                
SOURCE  26 GENE: EIF2B1, EIF2BA;                                                
SOURCE  27 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  28 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE  29 MOL_ID: 5;                                                           
SOURCE  30 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  31 ORGANISM_COMMON: HUMAN;                                              
SOURCE  32 ORGANISM_TAXID: 9606;                                                
SOURCE  33 GENE: EIF2B3;                                                        
SOURCE  34 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  35 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE  36 MOL_ID: 6;                                                           
SOURCE  37 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  38 ORGANISM_COMMON: HUMAN;                                              
SOURCE  39 ORGANISM_TAXID: 9606;                                                
SOURCE  40 GENE: EIF2S1, EIF2A;                                                 
SOURCE  41 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  42 EXPRESSION_SYSTEM_TAXID: 562                                         
KEYWDS    EUKARYOTIC TRANSLATION INITIATION FACTOR 2B, EUKARYOTIC TRANSLATION   
KEYWDS   2 INITIATION FACTOR 2, TRANSLATION                                     
EXPDTA    ELECTRON MICROSCOPY                                                   
AUTHOR    H.C.NGUYEN,L.R.KENNER,A.S.FROST                                       
REVDAT   3   18-DEC-19 6O9Z    1       CRYST1 SCALE                             
REVDAT   2   20-NOV-19 6O9Z    1       REMARK                                   
REVDAT   1   15-MAY-19 6O9Z    0                                                
JRNL        AUTH   L.R.KENNER,A.A.ANAND,H.C.NGUYEN,A.G.MYASNIKOV,C.J.KLOSE,     
JRNL        AUTH 2 L.A.MCGEEVER,J.C.TSAI,L.E.MILLER-VEDAM,P.WALTER,A.FROST      
JRNL        TITL   EIF2B-CATALYZED NUCLEOTIDE EXCHANGE AND PHOSPHOREGULATION BY 
JRNL        TITL 2 THE INTEGRATED STRESS RESPONSE.                              
JRNL        REF    SCIENCE                       V. 364   491 2019              
JRNL        REFN                   ESSN 1095-9203                               
JRNL        PMID   31048491                                                     
JRNL        DOI    10.1126/SCIENCE.AAW2922                                      
REMARK   2                                                                      
REMARK   2 RESOLUTION.    3.03 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   SOFTWARE PACKAGES      : NULL                                      
REMARK   3   RECONSTRUCTION SCHEMA  : NULL                                      
REMARK   3                                                                      
REMARK   3 EM MAP-MODEL FITTING AND REFINEMENT                                  
REMARK   3   PDB ENTRY                    : NULL                                
REMARK   3   REFINEMENT SPACE             : NULL                                
REMARK   3   REFINEMENT PROTOCOL          : NULL                                
REMARK   3   REFINEMENT TARGET            : NULL                                
REMARK   3   OVERALL ANISOTROPIC B VALUE  : NULL                                
REMARK   3                                                                      
REMARK   3 FITTING PROCEDURE : NULL                                             
REMARK   3                                                                      
REMARK   3 EM IMAGE RECONSTRUCTION STATISTICS                                   
REMARK   3   NOMINAL PIXEL SIZE (ANGSTROMS)    : NULL                           
REMARK   3   ACTUAL PIXEL SIZE  (ANGSTROMS)    : NULL                           
REMARK   3   EFFECTIVE RESOLUTION (ANGSTROMS)  : 3.030                          
REMARK   3   NUMBER OF PARTICLES               : 34014                          
REMARK   3   CTF CORRECTION METHOD             : PHASE FLIPPING AND AMPLITUDE   
REMARK   3                                       CORRECTION                     
REMARK   3                                                                      
REMARK   3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL                    
REMARK   3                                                                      
REMARK   3 OTHER DETAILS: NULL                                                  
REMARK   4                                                                      
REMARK   4 6O9Z COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 18-MAR-19.                  
REMARK 100 THE DEPOSITION ID IS D_1000238698.                                   
REMARK 245                                                                      
REMARK 245 EXPERIMENTAL DETAILS                                                 
REMARK 245   RECONSTRUCTION METHOD          : SINGLE PARTICLE                   
REMARK 245   SPECIMEN TYPE                  : NULL                              
REMARK 245                                                                      
REMARK 245 ELECTRON MICROSCOPE SAMPLE                                           
REMARK 245   SAMPLE TYPE                    : PARTICLE                          
REMARK 245   PARTICLE TYPE                  : POINT                             
REMARK 245   NAME OF SAMPLE                 : EIF2 ALPHA-P BOUND TO EIF2B       
REMARK 245   SAMPLE CONCENTRATION (MG ML-1) : NULL                              
REMARK 245   SAMPLE SUPPORT DETAILS         : UNSPECIFIED                       
REMARK 245   SAMPLE VITRIFICATION DETAILS   : NULL                              
REMARK 245   SAMPLE BUFFER                  : NULL                              
REMARK 245   PH                             : 7.50                              
REMARK 245   SAMPLE DETAILS                 : NULL                              
REMARK 245                                                                      
REMARK 245 DATA ACQUISITION                                                     
REMARK 245   DATE OF EXPERIMENT                : NULL                           
REMARK 245   NUMBER OF MICROGRAPHS-IMAGES      : NULL                           
REMARK 245   TEMPERATURE (KELVIN)              : NULL                           
REMARK 245   MICROSCOPE MODEL                  : FEI TITAN KRIOS                
REMARK 245   DETECTOR TYPE                     : GATAN K2 SUMMIT (4K X 4K)      
REMARK 245   MINIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MAXIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MINIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   MAXIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   NOMINAL CS                        : NULL                           
REMARK 245   IMAGING MODE                      : BRIGHT FIELD                   
REMARK 245   ELECTRON DOSE (ELECTRONS NM**-2)  : 80.00                          
REMARK 245   ILLUMINATION MODE                 : FLOOD BEAM                     
REMARK 245   NOMINAL MAGNIFICATION             : NULL                           
REMARK 245   CALIBRATED MAGNIFICATION          : NULL                           
REMARK 245   SOURCE                            : FIELD EMISSION GUN             
REMARK 245   ACCELERATION VOLTAGE (KV)         : 300                            
REMARK 245   IMAGING DETAILS                   : NULL                           
REMARK 247                                                                      
REMARK 247 ELECTRON MICROSCOPY                                                  
REMARK 247  THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON          
REMARK 247  MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE              
REMARK 247  THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES           
REMARK 247  ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION         
REMARK 247  OF THE STRUCTURE FACTORS.                                           
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DODECAMERIC                       
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E, F, G, H, I, J,         
REMARK 350                    AND CHAINS: L, M                                  
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     MET A     1                                                      
REMARK 465     ALA A     2                                                      
REMARK 465     ALA A     3                                                      
REMARK 465     PRO A     4                                                      
REMARK 465     VAL A     5                                                      
REMARK 465     VAL A     6                                                      
REMARK 465     ALA A     7                                                      
REMARK 465     PRO A     8                                                      
REMARK 465     PRO A     9                                                      
REMARK 465     GLY A    10                                                      
REMARK 465     VAL A    11                                                      
REMARK 465     VAL A    12                                                      
REMARK 465     VAL A    13                                                      
REMARK 465     SER A    14                                                      
REMARK 465     ARG A    15                                                      
REMARK 465     ALA A    16                                                      
REMARK 465     ASN A    17                                                      
REMARK 465     LYS A    18                                                      
REMARK 465     ARG A    19                                                      
REMARK 465     SER A    20                                                      
REMARK 465     GLY A    21                                                      
REMARK 465     ALA A    22                                                      
REMARK 465     GLY A    23                                                      
REMARK 465     PRO A    24                                                      
REMARK 465     GLY A    25                                                      
REMARK 465     GLY A    26                                                      
REMARK 465     SER A    27                                                      
REMARK 465     GLY A    28                                                      
REMARK 465     GLY A    29                                                      
REMARK 465     GLY A    30                                                      
REMARK 465     GLY A    31                                                      
REMARK 465     ALA A    32                                                      
REMARK 465     ARG A    33                                                      
REMARK 465     GLY A    34                                                      
REMARK 465     ALA A    35                                                      
REMARK 465     GLU A    36                                                      
REMARK 465     GLU A    37                                                      
REMARK 465     GLU A    38                                                      
REMARK 465     PRO A    39                                                      
REMARK 465     PRO A    40                                                      
REMARK 465     ASP A   467                                                      
REMARK 465     ASP A   468                                                      
REMARK 465     SER A   469                                                      
REMARK 465     GLY A   470                                                      
REMARK 465     ALA A   471                                                      
REMARK 465     ASP A   472                                                      
REMARK 465     GLN A   473                                                      
REMARK 465     GLU A   474                                                      
REMARK 465     LYS A   475                                                      
REMARK 465     ASP A   476                                                      
REMARK 465     LYS A   477                                                      
REMARK 465     VAL A   478                                                      
REMARK 465     LYS A   479                                                      
REMARK 465     MET A   480                                                      
REMARK 465     LYS A   481                                                      
REMARK 465     GLY A   482                                                      
REMARK 465     TYR A   483                                                      
REMARK 465     ASN A   484                                                      
REMARK 465     PRO A   485                                                      
REMARK 465     ALA A   486                                                      
REMARK 465     GLU A   487                                                      
REMARK 465     VAL A   488                                                      
REMARK 465     GLY A   489                                                      
REMARK 465     ALA A   490                                                      
REMARK 465     ALA A   491                                                      
REMARK 465     GLY A   492                                                      
REMARK 465     LYS A   493                                                      
REMARK 465     GLY A   494                                                      
REMARK 465     TYR A   495                                                      
REMARK 465     LEU A   496                                                      
REMARK 465     TRP A   497                                                      
REMARK 465     LYS A   498                                                      
REMARK 465     ALA A   499                                                      
REMARK 465     ALA A   500                                                      
REMARK 465     GLY A   501                                                      
REMARK 465     MET A   502                                                      
REMARK 465     ASN A   503                                                      
REMARK 465     MET A   504                                                      
REMARK 465     GLU A   505                                                      
REMARK 465     GLU A   506                                                      
REMARK 465     GLU A   507                                                      
REMARK 465     GLU A   508                                                      
REMARK 465     GLU A   509                                                      
REMARK 465     LEU A   510                                                      
REMARK 465     GLN A   511                                                      
REMARK 465     GLN A   512                                                      
REMARK 465     ASN A   513                                                      
REMARK 465     LEU A   514                                                      
REMARK 465     TRP A   515                                                      
REMARK 465     GLY A   516                                                      
REMARK 465     LEU A   517                                                      
REMARK 465     LYS A   518                                                      
REMARK 465     ILE A   519                                                      
REMARK 465     ASN A   520                                                      
REMARK 465     MET A   521                                                      
REMARK 465     GLU A   522                                                      
REMARK 465     GLU A   523                                                      
REMARK 465     GLU A   524                                                      
REMARK 465     SER A   525                                                      
REMARK 465     GLU A   526                                                      
REMARK 465     SER A   527                                                      
REMARK 465     GLU A   528                                                      
REMARK 465     SER A   529                                                      
REMARK 465     GLU A   530                                                      
REMARK 465     GLN A   531                                                      
REMARK 465     SER A   532                                                      
REMARK 465     MET A   533                                                      
REMARK 465     ASP A   534                                                      
REMARK 465     SER A   535                                                      
REMARK 465     GLU A   536                                                      
REMARK 465     GLU A   537                                                      
REMARK 465     PRO A   538                                                      
REMARK 465     ASP A   539                                                      
REMARK 465     SER A   540                                                      
REMARK 465     ARG A   541                                                      
REMARK 465     GLY A   542                                                      
REMARK 465     GLY A   543                                                      
REMARK 465     SER A   544                                                      
REMARK 465     PRO A   545                                                      
REMARK 465     GLN A   546                                                      
REMARK 465     MET A   547                                                      
REMARK 465     ASP A   548                                                      
REMARK 465     ASP A   549                                                      
REMARK 465     ILE A   550                                                      
REMARK 465     LYS A   551                                                      
REMARK 465     VAL A   552                                                      
REMARK 465     PHE A   553                                                      
REMARK 465     GLN A   554                                                      
REMARK 465     ASN A   555                                                      
REMARK 465     GLU A   556                                                      
REMARK 465     VAL A   557                                                      
REMARK 465     LEU A   558                                                      
REMARK 465     GLY A   559                                                      
REMARK 465     THR A   560                                                      
REMARK 465     LEU A   561                                                      
REMARK 465     GLN A   562                                                      
REMARK 465     ARG A   563                                                      
REMARK 465     GLY A   564                                                      
REMARK 465     LYS A   565                                                      
REMARK 465     GLU A   566                                                      
REMARK 465     GLU A   567                                                      
REMARK 465     ASN A   568                                                      
REMARK 465     ILE A   569                                                      
REMARK 465     SER A   570                                                      
REMARK 465     CYS A   571                                                      
REMARK 465     ASP A   572                                                      
REMARK 465     ASN A   573                                                      
REMARK 465     LEU A   574                                                      
REMARK 465     VAL A   575                                                      
REMARK 465     LEU A   576                                                      
REMARK 465     GLU A   577                                                      
REMARK 465     ILE A   578                                                      
REMARK 465     ASN A   579                                                      
REMARK 465     SER A   580                                                      
REMARK 465     LEU A   581                                                      
REMARK 465     LYS A   582                                                      
REMARK 465     TYR A   583                                                      
REMARK 465     ALA A   584                                                      
REMARK 465     TYR A   585                                                      
REMARK 465     ASN A   586                                                      
REMARK 465     VAL A   587                                                      
REMARK 465     SER A   588                                                      
REMARK 465     LEU A   589                                                      
REMARK 465     LYS A   590                                                      
REMARK 465     GLU A   591                                                      
REMARK 465     VAL A   592                                                      
REMARK 465     MET A   593                                                      
REMARK 465     GLN A   594                                                      
REMARK 465     VAL A   595                                                      
REMARK 465     LEU A   596                                                      
REMARK 465     SER A   597                                                      
REMARK 465     HIS A   598                                                      
REMARK 465     VAL A   599                                                      
REMARK 465     VAL A   600                                                      
REMARK 465     LEU A   601                                                      
REMARK 465     GLU A   602                                                      
REMARK 465     PHE A   603                                                      
REMARK 465     PRO A   604                                                      
REMARK 465     LEU A   605                                                      
REMARK 465     GLN A   606                                                      
REMARK 465     GLN A   607                                                      
REMARK 465     MET A   608                                                      
REMARK 465     ASP A   609                                                      
REMARK 465     SER A   610                                                      
REMARK 465     PRO A   611                                                      
REMARK 465     LEU A   612                                                      
REMARK 465     ASP A   613                                                      
REMARK 465     SER A   614                                                      
REMARK 465     SER A   615                                                      
REMARK 465     ARG A   616                                                      
REMARK 465     TYR A   617                                                      
REMARK 465     CYS A   618                                                      
REMARK 465     ALA A   619                                                      
REMARK 465     LEU A   620                                                      
REMARK 465     LEU A   621                                                      
REMARK 465     LEU A   622                                                      
REMARK 465     PRO A   623                                                      
REMARK 465     LEU A   624                                                      
REMARK 465     LEU A   625                                                      
REMARK 465     LYS A   626                                                      
REMARK 465     ALA A   627                                                      
REMARK 465     TRP A   628                                                      
REMARK 465     SER A   629                                                      
REMARK 465     PRO A   630                                                      
REMARK 465     VAL A   631                                                      
REMARK 465     PHE A   632                                                      
REMARK 465     ARG A   633                                                      
REMARK 465     ASN A   634                                                      
REMARK 465     TYR A   635                                                      
REMARK 465     ILE A   636                                                      
REMARK 465     LYS A   637                                                      
REMARK 465     ARG A   638                                                      
REMARK 465     ALA A   639                                                      
REMARK 465     ALA A   640                                                      
REMARK 465     ASP A   641                                                      
REMARK 465     HIS A   642                                                      
REMARK 465     LEU A   643                                                      
REMARK 465     GLU A   644                                                      
REMARK 465     ALA A   645                                                      
REMARK 465     LEU A   646                                                      
REMARK 465     ALA A   647                                                      
REMARK 465     ALA A   648                                                      
REMARK 465     ILE A   649                                                      
REMARK 465     GLU A   650                                                      
REMARK 465     ASP A   651                                                      
REMARK 465     PHE A   652                                                      
REMARK 465     PHE A   653                                                      
REMARK 465     LEU A   654                                                      
REMARK 465     GLU A   655                                                      
REMARK 465     HIS A   656                                                      
REMARK 465     GLU A   657                                                      
REMARK 465     ALA A   658                                                      
REMARK 465     LEU A   659                                                      
REMARK 465     GLY A   660                                                      
REMARK 465     ILE A   661                                                      
REMARK 465     SER A   662                                                      
REMARK 465     MET A   663                                                      
REMARK 465     ALA A   664                                                      
REMARK 465     LYS A   665                                                      
REMARK 465     VAL A   666                                                      
REMARK 465     LEU A   667                                                      
REMARK 465     MET A   668                                                      
REMARK 465     ALA A   669                                                      
REMARK 465     PHE A   670                                                      
REMARK 465     TYR A   671                                                      
REMARK 465     GLN A   672                                                      
REMARK 465     LEU A   673                                                      
REMARK 465     GLU A   674                                                      
REMARK 465     ILE A   675                                                      
REMARK 465     LEU A   676                                                      
REMARK 465     ALA A   677                                                      
REMARK 465     GLU A   678                                                      
REMARK 465     GLU A   679                                                      
REMARK 465     THR A   680                                                      
REMARK 465     ILE A   681                                                      
REMARK 465     LEU A   682                                                      
REMARK 465     SER A   683                                                      
REMARK 465     TRP A   684                                                      
REMARK 465     PHE A   685                                                      
REMARK 465     SER A   686                                                      
REMARK 465     GLN A   687                                                      
REMARK 465     ARG A   688                                                      
REMARK 465     ASP A   689                                                      
REMARK 465     THR A   690                                                      
REMARK 465     THR A   691                                                      
REMARK 465     ASP A   692                                                      
REMARK 465     LYS A   693                                                      
REMARK 465     GLY A   694                                                      
REMARK 465     GLN A   695                                                      
REMARK 465     GLN A   696                                                      
REMARK 465     LEU A   697                                                      
REMARK 465     ARG A   698                                                      
REMARK 465     LYS A   699                                                      
REMARK 465     ASN A   700                                                      
REMARK 465     GLN A   701                                                      
REMARK 465     GLN A   702                                                      
REMARK 465     LEU A   703                                                      
REMARK 465     GLN A   704                                                      
REMARK 465     ARG A   705                                                      
REMARK 465     PHE A   706                                                      
REMARK 465     ILE A   707                                                      
REMARK 465     GLN A   708                                                      
REMARK 465     TRP A   709                                                      
REMARK 465     LEU A   710                                                      
REMARK 465     LYS A   711                                                      
REMARK 465     GLU A   712                                                      
REMARK 465     ALA A   713                                                      
REMARK 465     GLU A   714                                                      
REMARK 465     GLU A   715                                                      
REMARK 465     GLU A   716                                                      
REMARK 465     SER A   717                                                      
REMARK 465     SER A   718                                                      
REMARK 465     GLU A   719                                                      
REMARK 465     ASP A   720                                                      
REMARK 465     ASP A   721                                                      
REMARK 465     MET B     1                                                      
REMARK 465     ALA B     2                                                      
REMARK 465     ALA B     3                                                      
REMARK 465     PRO B     4                                                      
REMARK 465     VAL B     5                                                      
REMARK 465     VAL B     6                                                      
REMARK 465     ALA B     7                                                      
REMARK 465     PRO B     8                                                      
REMARK 465     PRO B     9                                                      
REMARK 465     GLY B    10                                                      
REMARK 465     VAL B    11                                                      
REMARK 465     VAL B    12                                                      
REMARK 465     VAL B    13                                                      
REMARK 465     SER B    14                                                      
REMARK 465     ARG B    15                                                      
REMARK 465     ALA B    16                                                      
REMARK 465     ASN B    17                                                      
REMARK 465     LYS B    18                                                      
REMARK 465     ARG B    19                                                      
REMARK 465     SER B    20                                                      
REMARK 465     GLY B    21                                                      
REMARK 465     ALA B    22                                                      
REMARK 465     GLY B    23                                                      
REMARK 465     PRO B    24                                                      
REMARK 465     GLY B    25                                                      
REMARK 465     GLY B    26                                                      
REMARK 465     SER B    27                                                      
REMARK 465     GLY B    28                                                      
REMARK 465     GLY B    29                                                      
REMARK 465     GLY B    30                                                      
REMARK 465     GLY B    31                                                      
REMARK 465     ALA B    32                                                      
REMARK 465     ARG B    33                                                      
REMARK 465     GLY B    34                                                      
REMARK 465     ALA B    35                                                      
REMARK 465     GLU B    36                                                      
REMARK 465     GLU B    37                                                      
REMARK 465     GLU B    38                                                      
REMARK 465     PRO B    39                                                      
REMARK 465     PRO B    40                                                      
REMARK 465     ASP B   467                                                      
REMARK 465     ASP B   468                                                      
REMARK 465     SER B   469                                                      
REMARK 465     GLY B   470                                                      
REMARK 465     ALA B   471                                                      
REMARK 465     ASP B   472                                                      
REMARK 465     GLN B   473                                                      
REMARK 465     GLU B   474                                                      
REMARK 465     LYS B   475                                                      
REMARK 465     ASP B   476                                                      
REMARK 465     LYS B   477                                                      
REMARK 465     VAL B   478                                                      
REMARK 465     LYS B   479                                                      
REMARK 465     MET B   480                                                      
REMARK 465     LYS B   481                                                      
REMARK 465     GLY B   482                                                      
REMARK 465     TYR B   483                                                      
REMARK 465     ASN B   484                                                      
REMARK 465     PRO B   485                                                      
REMARK 465     ALA B   486                                                      
REMARK 465     GLU B   487                                                      
REMARK 465     VAL B   488                                                      
REMARK 465     GLY B   489                                                      
REMARK 465     ALA B   490                                                      
REMARK 465     ALA B   491                                                      
REMARK 465     GLY B   492                                                      
REMARK 465     LYS B   493                                                      
REMARK 465     GLY B   494                                                      
REMARK 465     TYR B   495                                                      
REMARK 465     LEU B   496                                                      
REMARK 465     TRP B   497                                                      
REMARK 465     LYS B   498                                                      
REMARK 465     ALA B   499                                                      
REMARK 465     ALA B   500                                                      
REMARK 465     GLY B   501                                                      
REMARK 465     MET B   502                                                      
REMARK 465     ASN B   503                                                      
REMARK 465     MET B   504                                                      
REMARK 465     GLU B   505                                                      
REMARK 465     GLU B   506                                                      
REMARK 465     GLU B   507                                                      
REMARK 465     GLU B   508                                                      
REMARK 465     GLU B   509                                                      
REMARK 465     LEU B   510                                                      
REMARK 465     GLN B   511                                                      
REMARK 465     GLN B   512                                                      
REMARK 465     ASN B   513                                                      
REMARK 465     LEU B   514                                                      
REMARK 465     TRP B   515                                                      
REMARK 465     GLY B   516                                                      
REMARK 465     LEU B   517                                                      
REMARK 465     LYS B   518                                                      
REMARK 465     ILE B   519                                                      
REMARK 465     ASN B   520                                                      
REMARK 465     MET B   521                                                      
REMARK 465     GLU B   522                                                      
REMARK 465     GLU B   523                                                      
REMARK 465     GLU B   524                                                      
REMARK 465     SER B   525                                                      
REMARK 465     GLU B   526                                                      
REMARK 465     SER B   527                                                      
REMARK 465     GLU B   528                                                      
REMARK 465     SER B   529                                                      
REMARK 465     GLU B   530                                                      
REMARK 465     GLN B   531                                                      
REMARK 465     SER B   532                                                      
REMARK 465     MET B   533                                                      
REMARK 465     ASP B   534                                                      
REMARK 465     SER B   535                                                      
REMARK 465     GLU B   536                                                      
REMARK 465     GLU B   537                                                      
REMARK 465     PRO B   538                                                      
REMARK 465     ASP B   539                                                      
REMARK 465     SER B   540                                                      
REMARK 465     ARG B   541                                                      
REMARK 465     GLY B   542                                                      
REMARK 465     GLY B   543                                                      
REMARK 465     SER B   544                                                      
REMARK 465     PRO B   545                                                      
REMARK 465     GLN B   546                                                      
REMARK 465     MET B   547                                                      
REMARK 465     ASP B   548                                                      
REMARK 465     ASP B   549                                                      
REMARK 465     ILE B   550                                                      
REMARK 465     LYS B   551                                                      
REMARK 465     VAL B   552                                                      
REMARK 465     PHE B   553                                                      
REMARK 465     GLN B   554                                                      
REMARK 465     ASN B   555                                                      
REMARK 465     GLU B   556                                                      
REMARK 465     VAL B   557                                                      
REMARK 465     LEU B   558                                                      
REMARK 465     GLY B   559                                                      
REMARK 465     THR B   560                                                      
REMARK 465     LEU B   561                                                      
REMARK 465     GLN B   562                                                      
REMARK 465     ARG B   563                                                      
REMARK 465     GLY B   564                                                      
REMARK 465     LYS B   565                                                      
REMARK 465     GLU B   566                                                      
REMARK 465     GLU B   567                                                      
REMARK 465     ASN B   568                                                      
REMARK 465     ILE B   569                                                      
REMARK 465     SER B   570                                                      
REMARK 465     CYS B   571                                                      
REMARK 465     ASP B   572                                                      
REMARK 465     ASN B   573                                                      
REMARK 465     LEU B   574                                                      
REMARK 465     VAL B   575                                                      
REMARK 465     LEU B   576                                                      
REMARK 465     GLU B   577                                                      
REMARK 465     ILE B   578                                                      
REMARK 465     ASN B   579                                                      
REMARK 465     SER B   580                                                      
REMARK 465     LEU B   581                                                      
REMARK 465     LYS B   582                                                      
REMARK 465     TYR B   583                                                      
REMARK 465     ALA B   584                                                      
REMARK 465     TYR B   585                                                      
REMARK 465     ASN B   586                                                      
REMARK 465     VAL B   587                                                      
REMARK 465     SER B   588                                                      
REMARK 465     LEU B   589                                                      
REMARK 465     LYS B   590                                                      
REMARK 465     GLU B   591                                                      
REMARK 465     VAL B   592                                                      
REMARK 465     MET B   593                                                      
REMARK 465     GLN B   594                                                      
REMARK 465     VAL B   595                                                      
REMARK 465     LEU B   596                                                      
REMARK 465     SER B   597                                                      
REMARK 465     HIS B   598                                                      
REMARK 465     VAL B   599                                                      
REMARK 465     VAL B   600                                                      
REMARK 465     LEU B   601                                                      
REMARK 465     GLU B   602                                                      
REMARK 465     PHE B   603                                                      
REMARK 465     PRO B   604                                                      
REMARK 465     LEU B   605                                                      
REMARK 465     GLN B   606                                                      
REMARK 465     GLN B   607                                                      
REMARK 465     MET B   608                                                      
REMARK 465     ASP B   609                                                      
REMARK 465     SER B   610                                                      
REMARK 465     PRO B   611                                                      
REMARK 465     LEU B   612                                                      
REMARK 465     ASP B   613                                                      
REMARK 465     SER B   614                                                      
REMARK 465     SER B   615                                                      
REMARK 465     ARG B   616                                                      
REMARK 465     TYR B   617                                                      
REMARK 465     CYS B   618                                                      
REMARK 465     ALA B   619                                                      
REMARK 465     LEU B   620                                                      
REMARK 465     LEU B   621                                                      
REMARK 465     LEU B   622                                                      
REMARK 465     PRO B   623                                                      
REMARK 465     LEU B   624                                                      
REMARK 465     LEU B   625                                                      
REMARK 465     LYS B   626                                                      
REMARK 465     ALA B   627                                                      
REMARK 465     TRP B   628                                                      
REMARK 465     SER B   629                                                      
REMARK 465     PRO B   630                                                      
REMARK 465     VAL B   631                                                      
REMARK 465     PHE B   632                                                      
REMARK 465     ARG B   633                                                      
REMARK 465     ASN B   634                                                      
REMARK 465     TYR B   635                                                      
REMARK 465     ILE B   636                                                      
REMARK 465     LYS B   637                                                      
REMARK 465     ARG B   638                                                      
REMARK 465     ALA B   639                                                      
REMARK 465     ALA B   640                                                      
REMARK 465     ASP B   641                                                      
REMARK 465     HIS B   642                                                      
REMARK 465     LEU B   643                                                      
REMARK 465     GLU B   644                                                      
REMARK 465     ALA B   645                                                      
REMARK 465     LEU B   646                                                      
REMARK 465     ALA B   647                                                      
REMARK 465     ALA B   648                                                      
REMARK 465     ILE B   649                                                      
REMARK 465     GLU B   650                                                      
REMARK 465     ASP B   651                                                      
REMARK 465     PHE B   652                                                      
REMARK 465     PHE B   653                                                      
REMARK 465     LEU B   654                                                      
REMARK 465     GLU B   655                                                      
REMARK 465     HIS B   656                                                      
REMARK 465     GLU B   657                                                      
REMARK 465     ALA B   658                                                      
REMARK 465     LEU B   659                                                      
REMARK 465     GLY B   660                                                      
REMARK 465     ILE B   661                                                      
REMARK 465     SER B   662                                                      
REMARK 465     MET B   663                                                      
REMARK 465     ALA B   664                                                      
REMARK 465     LYS B   665                                                      
REMARK 465     VAL B   666                                                      
REMARK 465     LEU B   667                                                      
REMARK 465     MET B   668                                                      
REMARK 465     ALA B   669                                                      
REMARK 465     PHE B   670                                                      
REMARK 465     TYR B   671                                                      
REMARK 465     GLN B   672                                                      
REMARK 465     LEU B   673                                                      
REMARK 465     GLU B   674                                                      
REMARK 465     ILE B   675                                                      
REMARK 465     LEU B   676                                                      
REMARK 465     ALA B   677                                                      
REMARK 465     GLU B   678                                                      
REMARK 465     GLU B   679                                                      
REMARK 465     THR B   680                                                      
REMARK 465     ILE B   681                                                      
REMARK 465     LEU B   682                                                      
REMARK 465     SER B   683                                                      
REMARK 465     TRP B   684                                                      
REMARK 465     PHE B   685                                                      
REMARK 465     SER B   686                                                      
REMARK 465     GLN B   687                                                      
REMARK 465     ARG B   688                                                      
REMARK 465     ASP B   689                                                      
REMARK 465     THR B   690                                                      
REMARK 465     THR B   691                                                      
REMARK 465     ASP B   692                                                      
REMARK 465     LYS B   693                                                      
REMARK 465     GLY B   694                                                      
REMARK 465     GLN B   695                                                      
REMARK 465     GLN B   696                                                      
REMARK 465     LEU B   697                                                      
REMARK 465     ARG B   698                                                      
REMARK 465     LYS B   699                                                      
REMARK 465     ASN B   700                                                      
REMARK 465     GLN B   701                                                      
REMARK 465     GLN B   702                                                      
REMARK 465     LEU B   703                                                      
REMARK 465     GLN B   704                                                      
REMARK 465     ARG B   705                                                      
REMARK 465     PHE B   706                                                      
REMARK 465     ILE B   707                                                      
REMARK 465     GLN B   708                                                      
REMARK 465     TRP B   709                                                      
REMARK 465     LEU B   710                                                      
REMARK 465     LYS B   711                                                      
REMARK 465     GLU B   712                                                      
REMARK 465     ALA B   713                                                      
REMARK 465     GLU B   714                                                      
REMARK 465     GLU B   715                                                      
REMARK 465     GLU B   716                                                      
REMARK 465     SER B   717                                                      
REMARK 465     SER B   718                                                      
REMARK 465     GLU B   719                                                      
REMARK 465     ASP B   720                                                      
REMARK 465     ASP B   721                                                      
REMARK 465     MET C   -16                                                      
REMARK 465     HIS C   -15                                                      
REMARK 465     HIS C   -14                                                      
REMARK 465     HIS C   -13                                                      
REMARK 465     HIS C   -12                                                      
REMARK 465     HIS C   -11                                                      
REMARK 465     HIS C   -10                                                      
REMARK 465     GLY C    -9                                                      
REMARK 465     GLY C    -8                                                      
REMARK 465     GLY C    -7                                                      
REMARK 465     SER C    -6                                                      
REMARK 465     GLU C    -5                                                      
REMARK 465     ASN C    -4                                                      
REMARK 465     LEU C    -3                                                      
REMARK 465     TYR C    -2                                                      
REMARK 465     PHE C    -1                                                      
REMARK 465     GLN C     0                                                      
REMARK 465     SER C     1                                                      
REMARK 465     PRO C     2                                                      
REMARK 465     GLY C     3                                                      
REMARK 465     SER C     4                                                      
REMARK 465     ALA C     5                                                      
REMARK 465     ALA C     6                                                      
REMARK 465     LYS C     7                                                      
REMARK 465     ARG C    99                                                      
REMARK 465     SER C   100                                                      
REMARK 465     ASP C   101                                                      
REMARK 465     GLU C   102                                                      
REMARK 465     SER C   103                                                      
REMARK 465     ASP C   104                                                      
REMARK 465     GLN C   105                                                      
REMARK 465     GLN C   106                                                      
REMARK 465     GLU C   107                                                      
REMARK 465     SER C   108                                                      
REMARK 465     LEU C   109                                                      
REMARK 465     HIS C   110                                                      
REMARK 465     LYS C   111                                                      
REMARK 465     LEU C   112                                                      
REMARK 465     LEU C   113                                                      
REMARK 465     THR C   114                                                      
REMARK 465     SER C   115                                                      
REMARK 465     GLY C   116                                                      
REMARK 465     GLY C   117                                                      
REMARK 465     LEU C   118                                                      
REMARK 465     ASN C   119                                                      
REMARK 465     GLU C   120                                                      
REMARK 465     ASP C   121                                                      
REMARK 465     PHE C   122                                                      
REMARK 465     SER C   123                                                      
REMARK 465     PHE C   124                                                      
REMARK 465     HIS C   125                                                      
REMARK 465     MET D   -16                                                      
REMARK 465     HIS D   -15                                                      
REMARK 465     HIS D   -14                                                      
REMARK 465     HIS D   -13                                                      
REMARK 465     HIS D   -12                                                      
REMARK 465     HIS D   -11                                                      
REMARK 465     HIS D   -10                                                      
REMARK 465     GLY D    -9                                                      
REMARK 465     GLY D    -8                                                      
REMARK 465     GLY D    -7                                                      
REMARK 465     SER D    -6                                                      
REMARK 465     GLU D    -5                                                      
REMARK 465     ASN D    -4                                                      
REMARK 465     LEU D    -3                                                      
REMARK 465     TYR D    -2                                                      
REMARK 465     PHE D    -1                                                      
REMARK 465     GLN D     0                                                      
REMARK 465     SER D     1                                                      
REMARK 465     PRO D     2                                                      
REMARK 465     GLY D     3                                                      
REMARK 465     SER D     4                                                      
REMARK 465     ALA D     5                                                      
REMARK 465     ALA D     6                                                      
REMARK 465     LYS D     7                                                      
REMARK 465     ARG D    99                                                      
REMARK 465     SER D   100                                                      
REMARK 465     ASP D   101                                                      
REMARK 465     GLU D   102                                                      
REMARK 465     SER D   103                                                      
REMARK 465     ASP D   104                                                      
REMARK 465     GLN D   105                                                      
REMARK 465     GLN D   106                                                      
REMARK 465     GLU D   107                                                      
REMARK 465     SER D   108                                                      
REMARK 465     LEU D   109                                                      
REMARK 465     HIS D   110                                                      
REMARK 465     LYS D   111                                                      
REMARK 465     LEU D   112                                                      
REMARK 465     LEU D   113                                                      
REMARK 465     THR D   114                                                      
REMARK 465     SER D   115                                                      
REMARK 465     GLY D   116                                                      
REMARK 465     GLY D   117                                                      
REMARK 465     LEU D   118                                                      
REMARK 465     ASN D   119                                                      
REMARK 465     GLU D   120                                                      
REMARK 465     ASP D   121                                                      
REMARK 465     PHE D   122                                                      
REMARK 465     SER D   123                                                      
REMARK 465     PHE D   124                                                      
REMARK 465     MET E     1                                                      
REMARK 465     ALA E     2                                                      
REMARK 465     ALA E     3                                                      
REMARK 465     VAL E     4                                                      
REMARK 465     ALA E     5                                                      
REMARK 465     VAL E     6                                                      
REMARK 465     ALA E     7                                                      
REMARK 465     VAL E     8                                                      
REMARK 465     ARG E     9                                                      
REMARK 465     GLU E    10                                                      
REMARK 465     ASP E    11                                                      
REMARK 465     SER E    12                                                      
REMARK 465     GLY E    13                                                      
REMARK 465     SER E    14                                                      
REMARK 465     GLY E    15                                                      
REMARK 465     MET E    16                                                      
REMARK 465     LYS E    17                                                      
REMARK 465     ALA E    18                                                      
REMARK 465     GLU E    19                                                      
REMARK 465     LEU E    20                                                      
REMARK 465     PRO E    21                                                      
REMARK 465     PRO E    22                                                      
REMARK 465     GLY E    23                                                      
REMARK 465     PRO E    24                                                      
REMARK 465     GLY E    25                                                      
REMARK 465     ALA E    26                                                      
REMARK 465     VAL E    27                                                      
REMARK 465     GLY E    28                                                      
REMARK 465     ARG E    29                                                      
REMARK 465     GLU E    30                                                      
REMARK 465     MET E    31                                                      
REMARK 465     THR E    32                                                      
REMARK 465     LYS E    33                                                      
REMARK 465     GLU E    34                                                      
REMARK 465     GLU E    35                                                      
REMARK 465     LYS E    36                                                      
REMARK 465     LEU E    37                                                      
REMARK 465     GLN E    38                                                      
REMARK 465     LEU E    39                                                      
REMARK 465     ARG E    40                                                      
REMARK 465     LYS E    41                                                      
REMARK 465     GLU E    42                                                      
REMARK 465     LYS E    43                                                      
REMARK 465     LYS E    44                                                      
REMARK 465     GLN E    45                                                      
REMARK 465     GLN E    46                                                      
REMARK 465     LYS E    47                                                      
REMARK 465     LYS E    48                                                      
REMARK 465     LYS E    49                                                      
REMARK 465     ARG E    50                                                      
REMARK 465     LYS E    51                                                      
REMARK 465     GLU E    52                                                      
REMARK 465     GLU E    53                                                      
REMARK 465     LYS E    54                                                      
REMARK 465     GLY E    55                                                      
REMARK 465     ALA E    56                                                      
REMARK 465     GLU E    57                                                      
REMARK 465     PRO E    58                                                      
REMARK 465     GLU E    59                                                      
REMARK 465     THR E    60                                                      
REMARK 465     GLY E    61                                                      
REMARK 465     SER E    62                                                      
REMARK 465     ALA E    63                                                      
REMARK 465     VAL E    64                                                      
REMARK 465     SER E    65                                                      
REMARK 465     ALA E    66                                                      
REMARK 465     ALA E    67                                                      
REMARK 465     GLN E    68                                                      
REMARK 465     CYS E    69                                                      
REMARK 465     GLN E    70                                                      
REMARK 465     VAL E    71                                                      
REMARK 465     GLY E    72                                                      
REMARK 465     PRO E    73                                                      
REMARK 465     THR E    74                                                      
REMARK 465     ARG E    75                                                      
REMARK 465     GLU E    76                                                      
REMARK 465     LEU E    77                                                      
REMARK 465     PRO E    78                                                      
REMARK 465     GLU E    79                                                      
REMARK 465     SER E    80                                                      
REMARK 465     GLY E    81                                                      
REMARK 465     ILE E    82                                                      
REMARK 465     GLN E    83                                                      
REMARK 465     LEU E    84                                                      
REMARK 465     GLY E    85                                                      
REMARK 465     THR E    86                                                      
REMARK 465     PRO E    87                                                      
REMARK 465     ARG E    88                                                      
REMARK 465     GLU E    89                                                      
REMARK 465     LYS E    90                                                      
REMARK 465     VAL E    91                                                      
REMARK 465     PRO E    92                                                      
REMARK 465     ALA E    93                                                      
REMARK 465     GLY E    94                                                      
REMARK 465     ARG E    95                                                      
REMARK 465     SER E    96                                                      
REMARK 465     LYS E    97                                                      
REMARK 465     ALA E    98                                                      
REMARK 465     GLU E    99                                                      
REMARK 465     LEU E   100                                                      
REMARK 465     ARG E   101                                                      
REMARK 465     ALA E   102                                                      
REMARK 465     GLU E   103                                                      
REMARK 465     ARG E   104                                                      
REMARK 465     ARG E   105                                                      
REMARK 465     ALA E   106                                                      
REMARK 465     LYS E   107                                                      
REMARK 465     GLN E   108                                                      
REMARK 465     GLU E   109                                                      
REMARK 465     ALA E   110                                                      
REMARK 465     GLU E   111                                                      
REMARK 465     ARG E   112                                                      
REMARK 465     ALA E   113                                                      
REMARK 465     LEU E   114                                                      
REMARK 465     LYS E   115                                                      
REMARK 465     GLN E   116                                                      
REMARK 465     ALA E   117                                                      
REMARK 465     ARG E   118                                                      
REMARK 465     LYS E   119                                                      
REMARK 465     GLY E   120                                                      
REMARK 465     GLU E   121                                                      
REMARK 465     GLN E   122                                                      
REMARK 465     GLY E   123                                                      
REMARK 465     GLY E   124                                                      
REMARK 465     PRO E   125                                                      
REMARK 465     PRO E   126                                                      
REMARK 465     PRO E   127                                                      
REMARK 465     LYS E   128                                                      
REMARK 465     ALA E   129                                                      
REMARK 465     SER E   130                                                      
REMARK 465     PRO E   131                                                      
REMARK 465     SER E   132                                                      
REMARK 465     THR E   133                                                      
REMARK 465     ALA E   134                                                      
REMARK 465     GLY E   135                                                      
REMARK 465     GLU E   136                                                      
REMARK 465     THR E   137                                                      
REMARK 465     PRO E   138                                                      
REMARK 465     SER E   139                                                      
REMARK 465     GLY E   140                                                      
REMARK 465     VAL E   141                                                      
REMARK 465     LYS E   142                                                      
REMARK 465     ARG E   143                                                      
REMARK 465     LEU E   144                                                      
REMARK 465     PRO E   145                                                      
REMARK 465     GLU E   146                                                      
REMARK 465     TYR E   147                                                      
REMARK 465     PRO E   148                                                      
REMARK 465     GLN E   149                                                      
REMARK 465     VAL E   150                                                      
REMARK 465     ASP E   151                                                      
REMARK 465     ASP E   152                                                      
REMARK 465     LEU E   153                                                      
REMARK 465     LEU E   154                                                      
REMARK 465     LEU E   155                                                      
REMARK 465     ARG E   156                                                      
REMARK 465     ARG E   157                                                      
REMARK 465     LEU E   158                                                      
REMARK 465     VAL E   159                                                      
REMARK 465     LYS E   160                                                      
REMARK 465     LYS E   161                                                      
REMARK 465     PRO E   162                                                      
REMARK 465     GLU E   163                                                      
REMARK 465     ARG E   164                                                      
REMARK 465     GLN E   165                                                      
REMARK 465     LYS E   519                                                      
REMARK 465     SER E   520                                                      
REMARK 465     SER E   521                                                      
REMARK 465     ASP E   522                                                      
REMARK 465     GLN E   523                                                      
REMARK 465     MET F     1                                                      
REMARK 465     ALA F     2                                                      
REMARK 465     ALA F     3                                                      
REMARK 465     VAL F     4                                                      
REMARK 465     ALA F     5                                                      
REMARK 465     VAL F     6                                                      
REMARK 465     ALA F     7                                                      
REMARK 465     VAL F     8                                                      
REMARK 465     ARG F     9                                                      
REMARK 465     GLU F    10                                                      
REMARK 465     ASP F    11                                                      
REMARK 465     SER F    12                                                      
REMARK 465     GLY F    13                                                      
REMARK 465     SER F    14                                                      
REMARK 465     GLY F    15                                                      
REMARK 465     MET F    16                                                      
REMARK 465     LYS F    17                                                      
REMARK 465     ALA F    18                                                      
REMARK 465     GLU F    19                                                      
REMARK 465     LEU F    20                                                      
REMARK 465     PRO F    21                                                      
REMARK 465     PRO F    22                                                      
REMARK 465     GLY F    23                                                      
REMARK 465     PRO F    24                                                      
REMARK 465     GLY F    25                                                      
REMARK 465     ALA F    26                                                      
REMARK 465     VAL F    27                                                      
REMARK 465     GLY F    28                                                      
REMARK 465     ARG F    29                                                      
REMARK 465     GLU F    30                                                      
REMARK 465     MET F    31                                                      
REMARK 465     THR F    32                                                      
REMARK 465     LYS F    33                                                      
REMARK 465     GLU F    34                                                      
REMARK 465     GLU F    35                                                      
REMARK 465     LYS F    36                                                      
REMARK 465     LEU F    37                                                      
REMARK 465     GLN F    38                                                      
REMARK 465     LEU F    39                                                      
REMARK 465     ARG F    40                                                      
REMARK 465     LYS F    41                                                      
REMARK 465     GLU F    42                                                      
REMARK 465     LYS F    43                                                      
REMARK 465     LYS F    44                                                      
REMARK 465     GLN F    45                                                      
REMARK 465     GLN F    46                                                      
REMARK 465     LYS F    47                                                      
REMARK 465     LYS F    48                                                      
REMARK 465     LYS F    49                                                      
REMARK 465     ARG F    50                                                      
REMARK 465     LYS F    51                                                      
REMARK 465     GLU F    52                                                      
REMARK 465     GLU F    53                                                      
REMARK 465     LYS F    54                                                      
REMARK 465     GLY F    55                                                      
REMARK 465     ALA F    56                                                      
REMARK 465     GLU F    57                                                      
REMARK 465     PRO F    58                                                      
REMARK 465     GLU F    59                                                      
REMARK 465     THR F    60                                                      
REMARK 465     GLY F    61                                                      
REMARK 465     SER F    62                                                      
REMARK 465     ALA F    63                                                      
REMARK 465     VAL F    64                                                      
REMARK 465     SER F    65                                                      
REMARK 465     ALA F    66                                                      
REMARK 465     ALA F    67                                                      
REMARK 465     GLN F    68                                                      
REMARK 465     CYS F    69                                                      
REMARK 465     GLN F    70                                                      
REMARK 465     VAL F    71                                                      
REMARK 465     GLY F    72                                                      
REMARK 465     PRO F    73                                                      
REMARK 465     THR F    74                                                      
REMARK 465     ARG F    75                                                      
REMARK 465     GLU F    76                                                      
REMARK 465     LEU F    77                                                      
REMARK 465     PRO F    78                                                      
REMARK 465     GLU F    79                                                      
REMARK 465     SER F    80                                                      
REMARK 465     GLY F    81                                                      
REMARK 465     ILE F    82                                                      
REMARK 465     GLN F    83                                                      
REMARK 465     LEU F    84                                                      
REMARK 465     GLY F    85                                                      
REMARK 465     THR F    86                                                      
REMARK 465     PRO F    87                                                      
REMARK 465     ARG F    88                                                      
REMARK 465     GLU F    89                                                      
REMARK 465     LYS F    90                                                      
REMARK 465     VAL F    91                                                      
REMARK 465     PRO F    92                                                      
REMARK 465     ALA F    93                                                      
REMARK 465     GLY F    94                                                      
REMARK 465     ARG F    95                                                      
REMARK 465     SER F    96                                                      
REMARK 465     LYS F    97                                                      
REMARK 465     ALA F    98                                                      
REMARK 465     GLU F    99                                                      
REMARK 465     LEU F   100                                                      
REMARK 465     ARG F   101                                                      
REMARK 465     ALA F   102                                                      
REMARK 465     GLU F   103                                                      
REMARK 465     ARG F   104                                                      
REMARK 465     ARG F   105                                                      
REMARK 465     ALA F   106                                                      
REMARK 465     LYS F   107                                                      
REMARK 465     GLN F   108                                                      
REMARK 465     GLU F   109                                                      
REMARK 465     ALA F   110                                                      
REMARK 465     GLU F   111                                                      
REMARK 465     ARG F   112                                                      
REMARK 465     ALA F   113                                                      
REMARK 465     LEU F   114                                                      
REMARK 465     LYS F   115                                                      
REMARK 465     GLN F   116                                                      
REMARK 465     ALA F   117                                                      
REMARK 465     ARG F   118                                                      
REMARK 465     LYS F   119                                                      
REMARK 465     GLY F   120                                                      
REMARK 465     GLU F   121                                                      
REMARK 465     GLN F   122                                                      
REMARK 465     GLY F   123                                                      
REMARK 465     GLY F   124                                                      
REMARK 465     PRO F   125                                                      
REMARK 465     PRO F   126                                                      
REMARK 465     PRO F   127                                                      
REMARK 465     LYS F   128                                                      
REMARK 465     ALA F   129                                                      
REMARK 465     SER F   130                                                      
REMARK 465     PRO F   131                                                      
REMARK 465     SER F   132                                                      
REMARK 465     THR F   133                                                      
REMARK 465     ALA F   134                                                      
REMARK 465     GLY F   135                                                      
REMARK 465     GLU F   136                                                      
REMARK 465     THR F   137                                                      
REMARK 465     PRO F   138                                                      
REMARK 465     SER F   139                                                      
REMARK 465     GLY F   140                                                      
REMARK 465     VAL F   141                                                      
REMARK 465     LYS F   142                                                      
REMARK 465     ARG F   143                                                      
REMARK 465     LEU F   144                                                      
REMARK 465     PRO F   145                                                      
REMARK 465     GLU F   146                                                      
REMARK 465     TYR F   147                                                      
REMARK 465     PRO F   148                                                      
REMARK 465     GLN F   149                                                      
REMARK 465     VAL F   150                                                      
REMARK 465     ASP F   151                                                      
REMARK 465     ASP F   152                                                      
REMARK 465     LEU F   153                                                      
REMARK 465     LEU F   154                                                      
REMARK 465     LEU F   155                                                      
REMARK 465     ARG F   156                                                      
REMARK 465     ARG F   157                                                      
REMARK 465     LEU F   158                                                      
REMARK 465     VAL F   159                                                      
REMARK 465     LYS F   160                                                      
REMARK 465     LYS F   161                                                      
REMARK 465     PRO F   162                                                      
REMARK 465     GLU F   163                                                      
REMARK 465     ARG F   164                                                      
REMARK 465     GLN F   165                                                      
REMARK 465     LYS F   519                                                      
REMARK 465     SER F   520                                                      
REMARK 465     SER F   521                                                      
REMARK 465     ASP F   522                                                      
REMARK 465     GLN F   523                                                      
REMARK 465     LYS G   253                                                      
REMARK 465     ALA G   254                                                      
REMARK 465     ASP G   255                                                      
REMARK 465     THR G   256                                                      
REMARK 465     LEU G   257                                                      
REMARK 465     LYS G   258                                                      
REMARK 465     VAL G   259                                                      
REMARK 465     ALA G   260                                                      
REMARK 465     GLN G   261                                                      
REMARK 465     THR G   262                                                      
REMARK 465     GLY G   263                                                      
REMARK 465     GLN G   264                                                      
REMARK 465     ASP G   265                                                      
REMARK 465     LEU G   266                                                      
REMARK 465     LYS G   267                                                      
REMARK 465     LYS H   253                                                      
REMARK 465     ALA H   254                                                      
REMARK 465     ASP H   255                                                      
REMARK 465     THR H   256                                                      
REMARK 465     LEU H   257                                                      
REMARK 465     LYS H   258                                                      
REMARK 465     VAL H   259                                                      
REMARK 465     ALA H   260                                                      
REMARK 465     GLN H   261                                                      
REMARK 465     THR H   262                                                      
REMARK 465     GLY H   263                                                      
REMARK 465     GLN H   264                                                      
REMARK 465     ASP H   265                                                      
REMARK 465     LEU H   266                                                      
REMARK 465     LYS H   267                                                      
REMARK 465     GLY I    12                                                      
REMARK 465     GLY I    13                                                      
REMARK 465     SER I    14                                                      
REMARK 465     ARG I    15                                                      
REMARK 465     MET I    16                                                      
REMARK 465     THR I    17                                                      
REMARK 465     ASP I    18                                                      
REMARK 465     LEU I    19                                                      
REMARK 465     THR I    20                                                      
REMARK 465     SER I    21                                                      
REMARK 465     SER I    22                                                      
REMARK 465     ILE I    23                                                      
REMARK 465     PRO I    24                                                      
REMARK 465     LYS I    25                                                      
REMARK 465     PRO I    26                                                      
REMARK 465     LEU I    27                                                      
REMARK 465     GLY I   135                                                      
REMARK 465     GLN I   136                                                      
REMARK 465     ASP I   137                                                      
REMARK 465     SER I   138                                                      
REMARK 465     ILE I   139                                                      
REMARK 465     GLU I   140                                                      
REMARK 465     PRO I   141                                                      
REMARK 465     VAL I   142                                                      
REMARK 465     PRO I   143                                                      
REMARK 465     GLY I   144                                                      
REMARK 465     GLN I   145                                                      
REMARK 465     LYS I   146                                                      
REMARK 465     GLY I   147                                                      
REMARK 465     LYS I   148                                                      
REMARK 465     LYS I   149                                                      
REMARK 465     LYS I   150                                                      
REMARK 465     ALA I   151                                                      
REMARK 465     VAL I   152                                                      
REMARK 465     GLU I   153                                                      
REMARK 465     GLN I   154                                                      
REMARK 465     SER I   239                                                      
REMARK 465     ALA I   240                                                      
REMARK 465     SER I   241                                                      
REMARK 465     SER I   242                                                      
REMARK 465     GLN I   243                                                      
REMARK 465     GLN I   244                                                      
REMARK 465     GLY I   245                                                      
REMARK 465     GLN I   246                                                      
REMARK 465     GLU I   247                                                      
REMARK 465     GLU I   248                                                      
REMARK 465     LYS I   249                                                      
REMARK 465     GLU I   250                                                      
REMARK 465     GLU I   251                                                      
REMARK 465     ASP I   252                                                      
REMARK 465     LEU I   253                                                      
REMARK 465     LYS I   254                                                      
REMARK 465     LYS I   255                                                      
REMARK 465     LYS I   256                                                      
REMARK 465     GLU I   257                                                      
REMARK 465     SER I   296                                                      
REMARK 465     GLN I   297                                                      
REMARK 465     VAL I   298                                                      
REMARK 465     ARG I   299                                                      
REMARK 465     CYS I   300                                                      
REMARK 465     TYR I   301                                                      
REMARK 465     VAL I   302                                                      
REMARK 465     HIS I   303                                                      
REMARK 465     ILE I   304                                                      
REMARK 465     MET I   305                                                      
REMARK 465     LYS I   306                                                      
REMARK 465     GLU I   307                                                      
REMARK 465     GLY I   308                                                      
REMARK 465     LEU I   309                                                      
REMARK 465     CYS I   310                                                      
REMARK 465     SER I   311                                                      
REMARK 465     ARG I   312                                                      
REMARK 465     VAL I   313                                                      
REMARK 465     SER I   314                                                      
REMARK 465     THR I   315                                                      
REMARK 465     LEU I   316                                                      
REMARK 465     GLY I   317                                                      
REMARK 465     LEU I   318                                                      
REMARK 465     TYR I   319                                                      
REMARK 465     MET I   320                                                      
REMARK 465     GLU I   321                                                      
REMARK 465     ALA I   322                                                      
REMARK 465     ASN I   323                                                      
REMARK 465     ARG I   324                                                      
REMARK 465     GLN I   325                                                      
REMARK 465     VAL I   326                                                      
REMARK 465     PRO I   327                                                      
REMARK 465     LYS I   328                                                      
REMARK 465     LEU I   329                                                      
REMARK 465     LEU I   330                                                      
REMARK 465     SER I   331                                                      
REMARK 465     ALA I   332                                                      
REMARK 465     LEU I   333                                                      
REMARK 465     CYS I   334                                                      
REMARK 465     PRO I   335                                                      
REMARK 465     GLU I   336                                                      
REMARK 465     GLU I   337                                                      
REMARK 465     PRO I   338                                                      
REMARK 465     PRO I   339                                                      
REMARK 465     VAL I   340                                                      
REMARK 465     HIS I   341                                                      
REMARK 465     SER I   342                                                      
REMARK 465     SER I   343                                                      
REMARK 465     ALA I   344                                                      
REMARK 465     GLN I   345                                                      
REMARK 465     ILE I   346                                                      
REMARK 465     VAL I   347                                                      
REMARK 465     SER I   348                                                      
REMARK 465     LYS I   349                                                      
REMARK 465     HIS I   350                                                      
REMARK 465     LEU I   351                                                      
REMARK 465     VAL I   352                                                      
REMARK 465     GLY I   353                                                      
REMARK 465     VAL I   354                                                      
REMARK 465     ASP I   355                                                      
REMARK 465     SER I   356                                                      
REMARK 465     LEU I   357                                                      
REMARK 465     ILE I   358                                                      
REMARK 465     GLY I   359                                                      
REMARK 465     PRO I   360                                                      
REMARK 465     GLU I   361                                                      
REMARK 465     THR I   362                                                      
REMARK 465     GLN I   363                                                      
REMARK 465     ILE I   364                                                      
REMARK 465     GLY I   365                                                      
REMARK 465     GLU I   366                                                      
REMARK 465     LYS I   367                                                      
REMARK 465     SER I   368                                                      
REMARK 465     SER I   369                                                      
REMARK 465     ILE I   370                                                      
REMARK 465     LYS I   371                                                      
REMARK 465     ARG I   372                                                      
REMARK 465     SER I   373                                                      
REMARK 465     VAL I   374                                                      
REMARK 465     ILE I   375                                                      
REMARK 465     GLY I   376                                                      
REMARK 465     SER I   377                                                      
REMARK 465     SER I   378                                                      
REMARK 465     CYS I   379                                                      
REMARK 465     LEU I   380                                                      
REMARK 465     ILE I   381                                                      
REMARK 465     LYS I   382                                                      
REMARK 465     ASP I   383                                                      
REMARK 465     ARG I   384                                                      
REMARK 465     VAL I   385                                                      
REMARK 465     THR I   386                                                      
REMARK 465     ILE I   387                                                      
REMARK 465     THR I   388                                                      
REMARK 465     ASN I   389                                                      
REMARK 465     CYS I   390                                                      
REMARK 465     LEU I   391                                                      
REMARK 465     LEU I   392                                                      
REMARK 465     MET I   393                                                      
REMARK 465     ASN I   394                                                      
REMARK 465     SER I   395                                                      
REMARK 465     VAL I   396                                                      
REMARK 465     THR I   397                                                      
REMARK 465     VAL I   398                                                      
REMARK 465     GLU I   399                                                      
REMARK 465     GLU I   400                                                      
REMARK 465     GLY I   401                                                      
REMARK 465     SER I   402                                                      
REMARK 465     ASN I   403                                                      
REMARK 465     ILE I   404                                                      
REMARK 465     GLN I   405                                                      
REMARK 465     GLY I   406                                                      
REMARK 465     SER I   407                                                      
REMARK 465     VAL I   408                                                      
REMARK 465     ILE I   409                                                      
REMARK 465     CYS I   410                                                      
REMARK 465     ASN I   411                                                      
REMARK 465     ASN I   412                                                      
REMARK 465     ALA I   413                                                      
REMARK 465     VAL I   414                                                      
REMARK 465     ILE I   415                                                      
REMARK 465     GLU I   416                                                      
REMARK 465     LYS I   417                                                      
REMARK 465     GLY I   418                                                      
REMARK 465     ALA I   419                                                      
REMARK 465     ASP I   420                                                      
REMARK 465     ILE I   421                                                      
REMARK 465     LYS I   422                                                      
REMARK 465     ASP I   423                                                      
REMARK 465     CYS I   424                                                      
REMARK 465     LEU I   425                                                      
REMARK 465     ILE I   426                                                      
REMARK 465     GLY I   427                                                      
REMARK 465     SER I   428                                                      
REMARK 465     GLY I   429                                                      
REMARK 465     GLN I   430                                                      
REMARK 465     ARG I   431                                                      
REMARK 465     ILE I   432                                                      
REMARK 465     GLU I   433                                                      
REMARK 465     ALA I   434                                                      
REMARK 465     LYS I   435                                                      
REMARK 465     ALA I   436                                                      
REMARK 465     LYS I   437                                                      
REMARK 465     ARG I   438                                                      
REMARK 465     VAL I   439                                                      
REMARK 465     ASN I   440                                                      
REMARK 465     GLU I   441                                                      
REMARK 465     VAL I   442                                                      
REMARK 465     ILE I   443                                                      
REMARK 465     VAL I   444                                                      
REMARK 465     GLY I   445                                                      
REMARK 465     ASN I   446                                                      
REMARK 465     ASP I   447                                                      
REMARK 465     GLN I   448                                                      
REMARK 465     LEU I   449                                                      
REMARK 465     MET I   450                                                      
REMARK 465     GLU I   451                                                      
REMARK 465     ILE I   452                                                      
REMARK 465     GLY J    12                                                      
REMARK 465     GLY J    13                                                      
REMARK 465     SER J    14                                                      
REMARK 465     ARG J    15                                                      
REMARK 465     MET J    16                                                      
REMARK 465     THR J    17                                                      
REMARK 465     ASP J    18                                                      
REMARK 465     LEU J    19                                                      
REMARK 465     THR J    20                                                      
REMARK 465     SER J    21                                                      
REMARK 465     SER J    22                                                      
REMARK 465     ILE J    23                                                      
REMARK 465     PRO J    24                                                      
REMARK 465     LYS J    25                                                      
REMARK 465     PRO J    26                                                      
REMARK 465     LEU J    27                                                      
REMARK 465     GLY J   135                                                      
REMARK 465     GLN J   136                                                      
REMARK 465     ASP J   137                                                      
REMARK 465     SER J   138                                                      
REMARK 465     ILE J   139                                                      
REMARK 465     GLU J   140                                                      
REMARK 465     PRO J   141                                                      
REMARK 465     VAL J   142                                                      
REMARK 465     PRO J   143                                                      
REMARK 465     GLY J   144                                                      
REMARK 465     GLN J   145                                                      
REMARK 465     LYS J   146                                                      
REMARK 465     GLY J   147                                                      
REMARK 465     LYS J   148                                                      
REMARK 465     LYS J   149                                                      
REMARK 465     LYS J   150                                                      
REMARK 465     ALA J   151                                                      
REMARK 465     VAL J   152                                                      
REMARK 465     GLU J   153                                                      
REMARK 465     GLN J   154                                                      
REMARK 465     SER J   239                                                      
REMARK 465     ALA J   240                                                      
REMARK 465     SER J   241                                                      
REMARK 465     SER J   242                                                      
REMARK 465     GLN J   243                                                      
REMARK 465     GLN J   244                                                      
REMARK 465     GLY J   245                                                      
REMARK 465     GLN J   246                                                      
REMARK 465     GLU J   247                                                      
REMARK 465     GLU J   248                                                      
REMARK 465     LYS J   249                                                      
REMARK 465     GLU J   250                                                      
REMARK 465     GLU J   251                                                      
REMARK 465     ASP J   252                                                      
REMARK 465     LEU J   253                                                      
REMARK 465     LYS J   254                                                      
REMARK 465     LYS J   255                                                      
REMARK 465     LYS J   256                                                      
REMARK 465     GLU J   257                                                      
REMARK 465     SER J   296                                                      
REMARK 465     GLN J   297                                                      
REMARK 465     VAL J   298                                                      
REMARK 465     ARG J   299                                                      
REMARK 465     CYS J   300                                                      
REMARK 465     TYR J   301                                                      
REMARK 465     VAL J   302                                                      
REMARK 465     HIS J   303                                                      
REMARK 465     ILE J   304                                                      
REMARK 465     MET J   305                                                      
REMARK 465     LYS J   306                                                      
REMARK 465     GLU J   307                                                      
REMARK 465     GLY J   308                                                      
REMARK 465     LEU J   309                                                      
REMARK 465     CYS J   310                                                      
REMARK 465     SER J   311                                                      
REMARK 465     ARG J   312                                                      
REMARK 465     VAL J   313                                                      
REMARK 465     SER J   314                                                      
REMARK 465     THR J   315                                                      
REMARK 465     LEU J   316                                                      
REMARK 465     GLY J   317                                                      
REMARK 465     LEU J   318                                                      
REMARK 465     TYR J   319                                                      
REMARK 465     MET J   320                                                      
REMARK 465     GLU J   321                                                      
REMARK 465     ALA J   322                                                      
REMARK 465     ASN J   323                                                      
REMARK 465     ARG J   324                                                      
REMARK 465     GLN J   325                                                      
REMARK 465     VAL J   326                                                      
REMARK 465     PRO J   327                                                      
REMARK 465     LYS J   328                                                      
REMARK 465     LEU J   329                                                      
REMARK 465     LEU J   330                                                      
REMARK 465     SER J   331                                                      
REMARK 465     ALA J   332                                                      
REMARK 465     LEU J   333                                                      
REMARK 465     CYS J   334                                                      
REMARK 465     PRO J   335                                                      
REMARK 465     GLU J   336                                                      
REMARK 465     GLU J   337                                                      
REMARK 465     PRO J   338                                                      
REMARK 465     PRO J   339                                                      
REMARK 465     VAL J   340                                                      
REMARK 465     HIS J   341                                                      
REMARK 465     SER J   342                                                      
REMARK 465     SER J   343                                                      
REMARK 465     ALA J   344                                                      
REMARK 465     GLN J   345                                                      
REMARK 465     ILE J   346                                                      
REMARK 465     VAL J   347                                                      
REMARK 465     SER J   348                                                      
REMARK 465     LYS J   349                                                      
REMARK 465     HIS J   350                                                      
REMARK 465     LEU J   351                                                      
REMARK 465     VAL J   352                                                      
REMARK 465     GLY J   353                                                      
REMARK 465     VAL J   354                                                      
REMARK 465     ASP J   355                                                      
REMARK 465     SER J   356                                                      
REMARK 465     LEU J   357                                                      
REMARK 465     ILE J   358                                                      
REMARK 465     GLY J   359                                                      
REMARK 465     PRO J   360                                                      
REMARK 465     GLU J   361                                                      
REMARK 465     THR J   362                                                      
REMARK 465     GLN J   363                                                      
REMARK 465     ILE J   364                                                      
REMARK 465     GLY J   365                                                      
REMARK 465     GLU J   366                                                      
REMARK 465     LYS J   367                                                      
REMARK 465     SER J   368                                                      
REMARK 465     SER J   369                                                      
REMARK 465     ILE J   370                                                      
REMARK 465     LYS J   371                                                      
REMARK 465     ARG J   372                                                      
REMARK 465     SER J   373                                                      
REMARK 465     VAL J   374                                                      
REMARK 465     ILE J   375                                                      
REMARK 465     GLY J   376                                                      
REMARK 465     SER J   377                                                      
REMARK 465     SER J   378                                                      
REMARK 465     CYS J   379                                                      
REMARK 465     LEU J   380                                                      
REMARK 465     ILE J   381                                                      
REMARK 465     LYS J   382                                                      
REMARK 465     ASP J   383                                                      
REMARK 465     ARG J   384                                                      
REMARK 465     VAL J   385                                                      
REMARK 465     THR J   386                                                      
REMARK 465     ILE J   387                                                      
REMARK 465     THR J   388                                                      
REMARK 465     ASN J   389                                                      
REMARK 465     CYS J   390                                                      
REMARK 465     LEU J   391                                                      
REMARK 465     LEU J   392                                                      
REMARK 465     MET J   393                                                      
REMARK 465     ASN J   394                                                      
REMARK 465     SER J   395                                                      
REMARK 465     VAL J   396                                                      
REMARK 465     THR J   397                                                      
REMARK 465     VAL J   398                                                      
REMARK 465     GLU J   399                                                      
REMARK 465     GLU J   400                                                      
REMARK 465     GLY J   401                                                      
REMARK 465     SER J   402                                                      
REMARK 465     ASN J   403                                                      
REMARK 465     ILE J   404                                                      
REMARK 465     GLN J   405                                                      
REMARK 465     GLY J   406                                                      
REMARK 465     SER J   407                                                      
REMARK 465     VAL J   408                                                      
REMARK 465     ILE J   409                                                      
REMARK 465     CYS J   410                                                      
REMARK 465     ASN J   411                                                      
REMARK 465     ASN J   412                                                      
REMARK 465     ALA J   413                                                      
REMARK 465     VAL J   414                                                      
REMARK 465     ILE J   415                                                      
REMARK 465     GLU J   416                                                      
REMARK 465     LYS J   417                                                      
REMARK 465     GLY J   418                                                      
REMARK 465     ALA J   419                                                      
REMARK 465     ASP J   420                                                      
REMARK 465     ILE J   421                                                      
REMARK 465     LYS J   422                                                      
REMARK 465     ASP J   423                                                      
REMARK 465     CYS J   424                                                      
REMARK 465     LEU J   425                                                      
REMARK 465     ILE J   426                                                      
REMARK 465     GLY J   427                                                      
REMARK 465     SER J   428                                                      
REMARK 465     GLY J   429                                                      
REMARK 465     GLN J   430                                                      
REMARK 465     ARG J   431                                                      
REMARK 465     ILE J   432                                                      
REMARK 465     GLU J   433                                                      
REMARK 465     ALA J   434                                                      
REMARK 465     LYS J   435                                                      
REMARK 465     ALA J   436                                                      
REMARK 465     LYS J   437                                                      
REMARK 465     ARG J   438                                                      
REMARK 465     VAL J   439                                                      
REMARK 465     ASN J   440                                                      
REMARK 465     GLU J   441                                                      
REMARK 465     VAL J   442                                                      
REMARK 465     ILE J   443                                                      
REMARK 465     VAL J   444                                                      
REMARK 465     GLY J   445                                                      
REMARK 465     ASN J   446                                                      
REMARK 465     ASP J   447                                                      
REMARK 465     GLN J   448                                                      
REMARK 465     LEU J   449                                                      
REMARK 465     MET J   450                                                      
REMARK 465     GLU J   451                                                      
REMARK 465     ILE J   452                                                      
REMARK 465     MET L    -8                                                      
REMARK 465     ASP L    -7                                                      
REMARK 465     TYR L    -6                                                      
REMARK 465     LYS L    -5                                                      
REMARK 465     ASP L    -4                                                      
REMARK 465     ASP L    -3                                                      
REMARK 465     ASP L    -2                                                      
REMARK 465     ASP L    -1                                                      
REMARK 465     LYS L     0                                                      
REMARK 465     PRO L     1                                                      
REMARK 465     GLY L     2                                                      
REMARK 465     LEU L     3                                                      
REMARK 465     SER L     4                                                      
REMARK 465     ARG L   181                                                      
REMARK 465     ARG L   182                                                      
REMARK 465     LEU L   183                                                      
REMARK 465     THR L   184                                                      
REMARK 465     PRO L   185                                                      
REMARK 465     GLN L   186                                                      
REMARK 465     ALA L   187                                                      
REMARK 465     VAL L   188                                                      
REMARK 465     LYS L   189                                                      
REMARK 465     ILE L   190                                                      
REMARK 465     ARG L   191                                                      
REMARK 465     ALA L   192                                                      
REMARK 465     ASP L   193                                                      
REMARK 465     ILE L   194                                                      
REMARK 465     GLU L   195                                                      
REMARK 465     VAL L   196                                                      
REMARK 465     ALA L   197                                                      
REMARK 465     CYS L   198                                                      
REMARK 465     TYR L   199                                                      
REMARK 465     GLY L   200                                                      
REMARK 465     TYR L   201                                                      
REMARK 465     GLU L   202                                                      
REMARK 465     GLY L   203                                                      
REMARK 465     ILE L   204                                                      
REMARK 465     ASP L   205                                                      
REMARK 465     ALA L   206                                                      
REMARK 465     VAL L   207                                                      
REMARK 465     LYS L   208                                                      
REMARK 465     GLU L   209                                                      
REMARK 465     ALA L   210                                                      
REMARK 465     LEU L   211                                                      
REMARK 465     ARG L   212                                                      
REMARK 465     ALA L   213                                                      
REMARK 465     GLY L   214                                                      
REMARK 465     LEU L   215                                                      
REMARK 465     ASN L   216                                                      
REMARK 465     CYS L   217                                                      
REMARK 465     SER L   218                                                      
REMARK 465     THR L   219                                                      
REMARK 465     GLU L   220                                                      
REMARK 465     ASN L   221                                                      
REMARK 465     MET L   222                                                      
REMARK 465     PRO L   223                                                      
REMARK 465     ILE L   224                                                      
REMARK 465     LYS L   225                                                      
REMARK 465     ILE L   226                                                      
REMARK 465     ASN L   227                                                      
REMARK 465     LEU L   228                                                      
REMARK 465     ILE L   229                                                      
REMARK 465     ALA L   230                                                      
REMARK 465     PRO L   231                                                      
REMARK 465     PRO L   232                                                      
REMARK 465     ARG L   233                                                      
REMARK 465     TYR L   234                                                      
REMARK 465     VAL L   235                                                      
REMARK 465     MET L   236                                                      
REMARK 465     THR L   237                                                      
REMARK 465     THR L   238                                                      
REMARK 465     THR L   239                                                      
REMARK 465     THR L   240                                                      
REMARK 465     LEU L   241                                                      
REMARK 465     GLU L   242                                                      
REMARK 465     ARG L   243                                                      
REMARK 465     THR L   244                                                      
REMARK 465     GLU L   245                                                      
REMARK 465     GLY L   246                                                      
REMARK 465     LEU L   247                                                      
REMARK 465     SER L   248                                                      
REMARK 465     VAL L   249                                                      
REMARK 465     LEU L   250                                                      
REMARK 465     SER L   251                                                      
REMARK 465     GLN L   252                                                      
REMARK 465     ALA L   253                                                      
REMARK 465     MET L   254                                                      
REMARK 465     ALA L   255                                                      
REMARK 465     VAL L   256                                                      
REMARK 465     ILE L   257                                                      
REMARK 465     LYS L   258                                                      
REMARK 465     GLU L   259                                                      
REMARK 465     LYS L   260                                                      
REMARK 465     ILE L   261                                                      
REMARK 465     GLU L   262                                                      
REMARK 465     GLU L   263                                                      
REMARK 465     LYS L   264                                                      
REMARK 465     ARG L   265                                                      
REMARK 465     GLY L   266                                                      
REMARK 465     VAL L   267                                                      
REMARK 465     PHE L   268                                                      
REMARK 465     ASN L   269                                                      
REMARK 465     VAL L   270                                                      
REMARK 465     GLN L   271                                                      
REMARK 465     MET L   272                                                      
REMARK 465     GLU L   273                                                      
REMARK 465     PRO L   274                                                      
REMARK 465     LYS L   275                                                      
REMARK 465     VAL L   276                                                      
REMARK 465     VAL L   277                                                      
REMARK 465     THR L   278                                                      
REMARK 465     ASP L   279                                                      
REMARK 465     THR L   280                                                      
REMARK 465     ASP L   281                                                      
REMARK 465     GLU L   282                                                      
REMARK 465     THR L   283                                                      
REMARK 465     GLU L   284                                                      
REMARK 465     LEU L   285                                                      
REMARK 465     ALA L   286                                                      
REMARK 465     ARG L   287                                                      
REMARK 465     GLN L   288                                                      
REMARK 465     MET L   289                                                      
REMARK 465     GLU L   290                                                      
REMARK 465     ARG L   291                                                      
REMARK 465     LEU L   292                                                      
REMARK 465     GLU L   293                                                      
REMARK 465     ARG L   294                                                      
REMARK 465     GLU L   295                                                      
REMARK 465     ASN L   296                                                      
REMARK 465     ALA L   297                                                      
REMARK 465     GLU L   298                                                      
REMARK 465     VAL L   299                                                      
REMARK 465     ASP L   300                                                      
REMARK 465     GLY L   301                                                      
REMARK 465     ASP L   302                                                      
REMARK 465     ASP L   303                                                      
REMARK 465     ASP L   304                                                      
REMARK 465     ALA L   305                                                      
REMARK 465     GLU L   306                                                      
REMARK 465     GLU L   307                                                      
REMARK 465     MET L   308                                                      
REMARK 465     GLU L   309                                                      
REMARK 465     ALA L   310                                                      
REMARK 465     LYS L   311                                                      
REMARK 465     ALA L   312                                                      
REMARK 465     GLU L   313                                                      
REMARK 465     ASP L   314                                                      
REMARK 465     MET M    -8                                                      
REMARK 465     ASP M    -7                                                      
REMARK 465     TYR M    -6                                                      
REMARK 465     LYS M    -5                                                      
REMARK 465     ASP M    -4                                                      
REMARK 465     ASP M    -3                                                      
REMARK 465     ASP M    -2                                                      
REMARK 465     ASP M    -1                                                      
REMARK 465     LYS M     0                                                      
REMARK 465     PRO M     1                                                      
REMARK 465     GLY M     2                                                      
REMARK 465     LEU M     3                                                      
REMARK 465     SER M     4                                                      
REMARK 465     ARG M   181                                                      
REMARK 465     ARG M   182                                                      
REMARK 465     LEU M   183                                                      
REMARK 465     THR M   184                                                      
REMARK 465     PRO M   185                                                      
REMARK 465     GLN M   186                                                      
REMARK 465     ALA M   187                                                      
REMARK 465     VAL M   188                                                      
REMARK 465     LYS M   189                                                      
REMARK 465     ILE M   190                                                      
REMARK 465     ARG M   191                                                      
REMARK 465     ALA M   192                                                      
REMARK 465     ASP M   193                                                      
REMARK 465     ILE M   194                                                      
REMARK 465     GLU M   195                                                      
REMARK 465     VAL M   196                                                      
REMARK 465     ALA M   197                                                      
REMARK 465     CYS M   198                                                      
REMARK 465     TYR M   199                                                      
REMARK 465     GLY M   200                                                      
REMARK 465     TYR M   201                                                      
REMARK 465     GLU M   202                                                      
REMARK 465     GLY M   203                                                      
REMARK 465     ILE M   204                                                      
REMARK 465     ASP M   205                                                      
REMARK 465     ALA M   206                                                      
REMARK 465     VAL M   207                                                      
REMARK 465     LYS M   208                                                      
REMARK 465     GLU M   209                                                      
REMARK 465     ALA M   210                                                      
REMARK 465     LEU M   211                                                      
REMARK 465     ARG M   212                                                      
REMARK 465     ALA M   213                                                      
REMARK 465     GLY M   214                                                      
REMARK 465     LEU M   215                                                      
REMARK 465     ASN M   216                                                      
REMARK 465     CYS M   217                                                      
REMARK 465     SER M   218                                                      
REMARK 465     THR M   219                                                      
REMARK 465     GLU M   220                                                      
REMARK 465     ASN M   221                                                      
REMARK 465     MET M   222                                                      
REMARK 465     PRO M   223                                                      
REMARK 465     ILE M   224                                                      
REMARK 465     LYS M   225                                                      
REMARK 465     ILE M   226                                                      
REMARK 465     ASN M   227                                                      
REMARK 465     LEU M   228                                                      
REMARK 465     ILE M   229                                                      
REMARK 465     ALA M   230                                                      
REMARK 465     PRO M   231                                                      
REMARK 465     PRO M   232                                                      
REMARK 465     ARG M   233                                                      
REMARK 465     TYR M   234                                                      
REMARK 465     VAL M   235                                                      
REMARK 465     MET M   236                                                      
REMARK 465     THR M   237                                                      
REMARK 465     THR M   238                                                      
REMARK 465     THR M   239                                                      
REMARK 465     THR M   240                                                      
REMARK 465     LEU M   241                                                      
REMARK 465     GLU M   242                                                      
REMARK 465     ARG M   243                                                      
REMARK 465     THR M   244                                                      
REMARK 465     GLU M   245                                                      
REMARK 465     GLY M   246                                                      
REMARK 465     LEU M   247                                                      
REMARK 465     SER M   248                                                      
REMARK 465     VAL M   249                                                      
REMARK 465     LEU M   250                                                      
REMARK 465     SER M   251                                                      
REMARK 465     GLN M   252                                                      
REMARK 465     ALA M   253                                                      
REMARK 465     MET M   254                                                      
REMARK 465     ALA M   255                                                      
REMARK 465     VAL M   256                                                      
REMARK 465     ILE M   257                                                      
REMARK 465     LYS M   258                                                      
REMARK 465     GLU M   259                                                      
REMARK 465     LYS M   260                                                      
REMARK 465     ILE M   261                                                      
REMARK 465     GLU M   262                                                      
REMARK 465     GLU M   263                                                      
REMARK 465     LYS M   264                                                      
REMARK 465     ARG M   265                                                      
REMARK 465     GLY M   266                                                      
REMARK 465     VAL M   267                                                      
REMARK 465     PHE M   268                                                      
REMARK 465     ASN M   269                                                      
REMARK 465     VAL M   270                                                      
REMARK 465     GLN M   271                                                      
REMARK 465     MET M   272                                                      
REMARK 465     GLU M   273                                                      
REMARK 465     PRO M   274                                                      
REMARK 465     LYS M   275                                                      
REMARK 465     VAL M   276                                                      
REMARK 465     VAL M   277                                                      
REMARK 465     THR M   278                                                      
REMARK 465     ASP M   279                                                      
REMARK 465     THR M   280                                                      
REMARK 465     ASP M   281                                                      
REMARK 465     GLU M   282                                                      
REMARK 465     THR M   283                                                      
REMARK 465     GLU M   284                                                      
REMARK 465     LEU M   285                                                      
REMARK 465     ALA M   286                                                      
REMARK 465     ARG M   287                                                      
REMARK 465     GLN M   288                                                      
REMARK 465     MET M   289                                                      
REMARK 465     GLU M   290                                                      
REMARK 465     ARG M   291                                                      
REMARK 465     LEU M   292                                                      
REMARK 465     GLU M   293                                                      
REMARK 465     ARG M   294                                                      
REMARK 465     GLU M   295                                                      
REMARK 465     ASN M   296                                                      
REMARK 465     ALA M   297                                                      
REMARK 465     GLU M   298                                                      
REMARK 465     VAL M   299                                                      
REMARK 465     ASP M   300                                                      
REMARK 465     GLY M   301                                                      
REMARK 465     ASP M   302                                                      
REMARK 465     ASP M   303                                                      
REMARK 465     ASP M   304                                                      
REMARK 465     ALA M   305                                                      
REMARK 465     GLU M   306                                                      
REMARK 465     GLU M   307                                                      
REMARK 465     MET M   308                                                      
REMARK 465     GLU M   309                                                      
REMARK 465     ALA M   310                                                      
REMARK 465     LYS M   311                                                      
REMARK 465     ALA M   312                                                      
REMARK 465     GLU M   313                                                      
REMARK 465     ASP M   314                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     ARG A  54    NH1  NH2                                            
REMARK 470     ARG A  55    NH1  NH2                                            
REMARK 470     ARG A  65    NH1  NH2                                            
REMARK 470     TYR A  78    OH                                                  
REMARK 470     TRP A  97    CH2                                                 
REMARK 470     TRP A 111    CH2                                                 
REMARK 470     ARG A 113    NH1  NH2                                            
REMARK 470     ARG A 121    NH1  NH2                                            
REMARK 470     GLU A 126    CG   CD   OE1  OE2                                  
REMARK 470     LEU A 127    CG   CD1  CD2                                       
REMARK 470     TYR A 128    OH                                                  
REMARK 470     ARG A 129    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG A 136    NH1  NH2                                            
REMARK 470     ARG A 145    NH1  NH2                                            
REMARK 470     TYR A 152    OH                                                  
REMARK 470     ARG A 163    NH1  NH2                                            
REMARK 470     ARG A 169    NH1  NH2                                            
REMARK 470     ARG A 171    NH1  NH2                                            
REMARK 470     ARG A 172    NH1  NH2                                            
REMARK 470     LYS A 176    CG   CD   CE   NZ                                   
REMARK 470     ASN A 177    CG   OD1  ND2                                       
REMARK 470     VAL A 178    CG1  CG2                                            
REMARK 470     ARG A 195    NH1  NH2                                            
REMARK 470     ARG A 211    NH1  NH2                                            
REMARK 470     GLN A 219    CG   CD   OE1  NE2                                  
REMARK 470     LEU A 221    CG   CD1  CD2                                       
REMARK 470     ARG A 222    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG A 223    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     SER A 229    OG                                                  
REMARK 470     GLN A 232    CG   CD   OE1  NE2                                  
REMARK 470     SER A 234    OG                                                  
REMARK 470     SER A 235    OG                                                  
REMARK 470     ASP A 236    CG   OD1  OD2                                       
REMARK 470     ARG A 241    NH1  NH2                                            
REMARK 470     TYR A 242    OH                                                  
REMARK 470     TYR A 266    OH                                                  
REMARK 470     ARG A 269    NH1  NH2                                            
REMARK 470     ARG A 274    NH1  NH2                                            
REMARK 470     ASN A 279    CG   OD1  ND2                                       
REMARK 470     LYS A 294    CG   CD   CE   NZ                                   
REMARK 470     TYR A 296    OH                                                  
REMARK 470     ARG A 299    NH1  NH2                                            
REMARK 470     TYR A 306    OH                                                  
REMARK 470     ARG A 315    NH1  NH2                                            
REMARK 470     ARG A 316    NH1  NH2                                            
REMARK 470     TRP A 317    CH2                                                 
REMARK 470     TYR A 319    OH                                                  
REMARK 470     ARG A 339    NH1  NH2                                            
REMARK 470     TYR A 343    OH                                                  
REMARK 470     ARG A 344    NH1  NH2                                            
REMARK 470     GLU A 347    CG   CD   OE1  OE2                                  
REMARK 470     TYR A 395    OH                                                  
REMARK 470     TRP A 397    CH2                                                 
REMARK 470     ARG A 401    NH1  NH2                                            
REMARK 470     GLU A 421    CG   CD   OE1  OE2                                  
REMARK 470     ARG A 422    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG A 428    NH1  NH2                                            
REMARK 470     GLN A 434    CG   CD   OE1  NE2                                  
REMARK 470     ASN A 440    CG   OD1  ND2                                       
REMARK 470     ILE A 441    CG1  CG2  CD1                                       
REMARK 470     GLU A 445    CG   CD   OE1  OE2                                  
REMARK 470     ASP A 455    CG   OD1  OD2                                       
REMARK 470     GLU A 457    CG   CD   OE1  OE2                                  
REMARK 470     GLU A 458    CG   CD   OE1  OE2                                  
REMARK 470     GLU A 460    CG   CD   OE1  OE2                                  
REMARK 470     ASP A 461    CG   OD1  OD2                                       
REMARK 470     ASP A 462    CG   OD1  OD2                                       
REMARK 470     GLU A 464    CG   CD   OE1  OE2                                  
REMARK 470     PHE A 465    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     SER A 466    OG                                                  
REMARK 470     ARG B  54    NH1  NH2                                            
REMARK 470     ARG B  55    NH1  NH2                                            
REMARK 470     ARG B  65    NH1  NH2                                            
REMARK 470     TYR B  78    OH                                                  
REMARK 470     TRP B  97    CH2                                                 
REMARK 470     TRP B 111    CH2                                                 
REMARK 470     ARG B 113    NH1  NH2                                            
REMARK 470     ARG B 121    NH1  NH2                                            
REMARK 470     GLU B 126    CG   CD   OE1  OE2                                  
REMARK 470     LEU B 127    CG   CD1  CD2                                       
REMARK 470     TYR B 128    OH                                                  
REMARK 470     ARG B 129    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG B 136    NH1  NH2                                            
REMARK 470     ARG B 145    NH1  NH2                                            
REMARK 470     TYR B 152    OH                                                  
REMARK 470     ARG B 163    NH1  NH2                                            
REMARK 470     ARG B 169    NH1  NH2                                            
REMARK 470     ARG B 171    NH1  NH2                                            
REMARK 470     ARG B 172    NH1  NH2                                            
REMARK 470     LYS B 176    CG   CD   CE   NZ                                   
REMARK 470     ASN B 177    CG   OD1  ND2                                       
REMARK 470     VAL B 178    CG1  CG2                                            
REMARK 470     ARG B 195    NH1  NH2                                            
REMARK 470     ARG B 211    NH1  NH2                                            
REMARK 470     GLN B 219    CG   CD   OE1  NE2                                  
REMARK 470     LEU B 221    CG   CD1  CD2                                       
REMARK 470     ARG B 222    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG B 223    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     SER B 229    OG                                                  
REMARK 470     GLN B 232    CG   CD   OE1  NE2                                  
REMARK 470     SER B 234    OG                                                  
REMARK 470     SER B 235    OG                                                  
REMARK 470     ASP B 236    CG   OD1  OD2                                       
REMARK 470     ARG B 241    NH1  NH2                                            
REMARK 470     TYR B 242    OH                                                  
REMARK 470     TYR B 266    OH                                                  
REMARK 470     ARG B 269    NH1  NH2                                            
REMARK 470     ARG B 274    NH1  NH2                                            
REMARK 470     ASN B 279    CG   OD1  ND2                                       
REMARK 470     LYS B 294    CG   CD   CE   NZ                                   
REMARK 470     TYR B 296    OH                                                  
REMARK 470     ARG B 299    NH1  NH2                                            
REMARK 470     TYR B 306    OH                                                  
REMARK 470     ARG B 315    NH1  NH2                                            
REMARK 470     ARG B 316    NH1  NH2                                            
REMARK 470     TRP B 317    CH2                                                 
REMARK 470     TYR B 319    OH                                                  
REMARK 470     ARG B 339    NH1  NH2                                            
REMARK 470     TYR B 343    OH                                                  
REMARK 470     ARG B 344    NH1  NH2                                            
REMARK 470     GLU B 347    CG   CD   OE1  OE2                                  
REMARK 470     TYR B 395    OH                                                  
REMARK 470     TRP B 397    CH2                                                 
REMARK 470     ARG B 401    NH1  NH2                                            
REMARK 470     GLU B 421    CG   CD   OE1  OE2                                  
REMARK 470     ARG B 422    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG B 428    NH1  NH2                                            
REMARK 470     GLN B 434    CG   CD   OE1  NE2                                  
REMARK 470     ASN B 440    CG   OD1  ND2                                       
REMARK 470     ILE B 441    CG1  CG2  CD1                                       
REMARK 470     GLU B 445    CG   CD   OE1  OE2                                  
REMARK 470     ASP B 455    CG   OD1  OD2                                       
REMARK 470     GLU B 457    CG   CD   OE1  OE2                                  
REMARK 470     GLU B 458    CG   CD   OE1  OE2                                  
REMARK 470     GLU B 460    CG   CD   OE1  OE2                                  
REMARK 470     ASP B 461    CG   OD1  OD2                                       
REMARK 470     ASP B 462    CG   OD1  OD2                                       
REMARK 470     GLU B 464    CG   CD   OE1  OE2                                  
REMARK 470     PHE B 465    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     SER B 466    OG                                                  
REMARK 470     ARG C  14    NH1  NH2                                            
REMARK 470     ARG C  24    NH1  NH2                                            
REMARK 470     ARG C  29    NH1  NH2                                            
REMARK 470     ARG C  36    NH1  NH2                                            
REMARK 470     ARG C  43    NH1  NH2                                            
REMARK 470     ARG C  50    NH1  NH2                                            
REMARK 470     TRP C  51    CH2                                                 
REMARK 470     ARG C  62    NH1  NH2                                            
REMARK 470     ARG C  63    NH1  NH2                                            
REMARK 470     ARG C  66    NH1  NH2                                            
REMARK 470     ARG C  67    NH1  NH2                                            
REMARK 470     ARG C  83    NH1  NH2                                            
REMARK 470     ARG C  84    NH1  NH2                                            
REMARK 470     ARG C  90    NH1  NH2                                            
REMARK 470     TYR C  93    OH                                                  
REMARK 470     ARG C  95    NH1  NH2                                            
REMARK 470     TYR C 126    OH                                                  
REMARK 470     ARG C 172    NH1  NH2                                            
REMARK 470     ARG C 183    NH1  NH2                                            
REMARK 470     ARG C 185    NH1  NH2                                            
REMARK 470     ARG C 228    NH1  NH2                                            
REMARK 470     ARG C 246    NH1  NH2                                            
REMARK 470     ASN C 280    CG   OD1  ND2                                       
REMARK 470     GLU C 281    CG   CD   OE1  OE2                                  
REMARK 470     GLU C 282    CG   CD   OE1  OE2                                  
REMARK 470     ASP C 283    CG   OD1  OD2                                       
REMARK 470     TYR C 315    OH                                                  
REMARK 470     TYR C 335    OH                                                  
REMARK 470     TYR C 337    OH                                                  
REMARK 470     ARG C 338    NH1  NH2                                            
REMARK 470     TYR C 344    OH                                                  
REMARK 470     ARG D  14    NH1  NH2                                            
REMARK 470     ARG D  24    NH1  NH2                                            
REMARK 470     ARG D  29    NH1  NH2                                            
REMARK 470     ARG D  36    NH1  NH2                                            
REMARK 470     ARG D  43    NH1  NH2                                            
REMARK 470     ARG D  50    NH1  NH2                                            
REMARK 470     TRP D  51    CH2                                                 
REMARK 470     ARG D  62    NH1  NH2                                            
REMARK 470     ARG D  63    NH1  NH2                                            
REMARK 470     ARG D  66    NH1  NH2                                            
REMARK 470     ARG D  67    NH1  NH2                                            
REMARK 470     ARG D  83    NH1  NH2                                            
REMARK 470     ARG D  84    NH1  NH2                                            
REMARK 470     ARG D  90    NH1  NH2                                            
REMARK 470     TYR D  93    OH                                                  
REMARK 470     ARG D  95    NH1  NH2                                            
REMARK 470     TYR D 126    OH                                                  
REMARK 470     ARG D 172    NH1  NH2                                            
REMARK 470     ARG D 183    NH1  NH2                                            
REMARK 470     ARG D 185    NH1  NH2                                            
REMARK 470     ARG D 228    NH1  NH2                                            
REMARK 470     ARG D 246    NH1  NH2                                            
REMARK 470     ASN D 280    CG   OD1  ND2                                       
REMARK 470     GLU D 281    CG   CD   OE1  OE2                                  
REMARK 470     GLU D 282    CG   CD   OE1  OE2                                  
REMARK 470     ASP D 283    CG   OD1  OD2                                       
REMARK 470     TYR D 315    OH                                                  
REMARK 470     TYR D 335    OH                                                  
REMARK 470     TYR D 337    OH                                                  
REMARK 470     ARG D 338    NH1  NH2                                            
REMARK 470     TYR D 344    OH                                                  
REMARK 470     ARG E 170    NH1  NH2                                            
REMARK 470     TYR E 173    OH                                                  
REMARK 470     TYR E 186    OH                                                  
REMARK 470     ARG E 188    NH1  NH2                                            
REMARK 470     GLN E 194    CG   CD   OE1  NE2                                  
REMARK 470     ARG E 209    NH1  NH2                                            
REMARK 470     TYR E 214    OH                                                  
REMARK 470     ARG E 225    NH1  NH2                                            
REMARK 470     ARG E 231    NH1  NH2                                            
REMARK 470     TYR E 240    OH                                                  
REMARK 470     ARG E 250    NH1  NH2                                            
REMARK 470     TYR E 259    OH                                                  
REMARK 470     ARG E 267    NH1  NH2                                            
REMARK 470     ARG E 292    NH1  NH2                                            
REMARK 470     ARG E 301    NH1  NH2                                            
REMARK 470     ARG E 306    NH1  NH2                                            
REMARK 470     TYR E 307    OH                                                  
REMARK 470     ARG E 321    NH1  NH2                                            
REMARK 470     TYR E 324    OH                                                  
REMARK 470     TYR E 336    OH                                                  
REMARK 470     ARG E 344    NH1  NH2                                            
REMARK 470     TRP E 350    CH2                                                 
REMARK 470     ARG E 354    NH1  NH2                                            
REMARK 470     ARG E 355    NH1  NH2                                            
REMARK 470     ARG E 357    NH1  NH2                                            
REMARK 470     ARG E 364    NH1  NH2                                            
REMARK 470     TRP E 366    CH2                                                 
REMARK 470     ARG E 370    NH1  NH2                                            
REMARK 470     ARG E 374    NH1  NH2                                            
REMARK 470     TYR E 385    OH                                                  
REMARK 470     TYR E 393    OH                                                  
REMARK 470     ARG E 417    NH1  NH2                                            
REMARK 470     ARG E 428    NH1  NH2                                            
REMARK 470     TYR E 441    OH                                                  
REMARK 470     ARG E 446    NH1  NH2                                            
REMARK 470     ARG E 467    NH1  NH2                                            
REMARK 470     TRP E 476    CH2                                                 
REMARK 470     ARG E 483    NH1  NH2                                            
REMARK 470     TYR E 489    OH                                                  
REMARK 470     VAL E 514    CG1  CG2                                            
REMARK 470     ARG F 170    NH1  NH2                                            
REMARK 470     TYR F 173    OH                                                  
REMARK 470     TYR F 186    OH                                                  
REMARK 470     ARG F 188    NH1  NH2                                            
REMARK 470     GLN F 194    CG   CD   OE1  NE2                                  
REMARK 470     ARG F 209    NH1  NH2                                            
REMARK 470     TYR F 214    OH                                                  
REMARK 470     ARG F 225    NH1  NH2                                            
REMARK 470     ARG F 231    NH1  NH2                                            
REMARK 470     TYR F 240    OH                                                  
REMARK 470     ARG F 250    NH1  NH2                                            
REMARK 470     TYR F 259    OH                                                  
REMARK 470     ARG F 267    NH1  NH2                                            
REMARK 470     ARG F 292    NH1  NH2                                            
REMARK 470     ARG F 301    NH1  NH2                                            
REMARK 470     ARG F 306    NH1  NH2                                            
REMARK 470     TYR F 307    OH                                                  
REMARK 470     ARG F 321    NH1  NH2                                            
REMARK 470     TYR F 324    OH                                                  
REMARK 470     TYR F 336    OH                                                  
REMARK 470     ARG F 344    NH1  NH2                                            
REMARK 470     TRP F 350    CH2                                                 
REMARK 470     ARG F 354    NH1  NH2                                            
REMARK 470     ARG F 355    NH1  NH2                                            
REMARK 470     ARG F 357    NH1  NH2                                            
REMARK 470     ARG F 364    NH1  NH2                                            
REMARK 470     TRP F 366    CH2                                                 
REMARK 470     ARG F 370    NH1  NH2                                            
REMARK 470     ARG F 374    NH1  NH2                                            
REMARK 470     TYR F 385    OH                                                  
REMARK 470     TYR F 393    OH                                                  
REMARK 470     ARG F 417    NH1  NH2                                            
REMARK 470     ARG F 428    NH1  NH2                                            
REMARK 470     TYR F 441    OH                                                  
REMARK 470     ARG F 446    NH1  NH2                                            
REMARK 470     ARG F 467    NH1  NH2                                            
REMARK 470     TRP F 476    CH2                                                 
REMARK 470     ARG F 483    NH1  NH2                                            
REMARK 470     TYR F 489    OH                                                  
REMARK 470     VAL F 514    CG1  CG2                                            
REMARK 470     ASP G   2    CG   OD1  OD2                                       
REMARK 470     ASP G   3    CG   OD1  OD2                                       
REMARK 470     GLU G   5    CG   CD   OE1  OE2                                  
REMARK 470     ILE G   7    CG1  CG2  CD1                                       
REMARK 470     GLU G   8    CG   CD   OE1  OE2                                  
REMARK 470     TYR G   9    OH                                                  
REMARK 470     SER G  12    OG                                                  
REMARK 470     MET G  14    CG   SD   CE                                        
REMARK 470     LYS G  15    CG   CD   CE   NZ                                   
REMARK 470     GLU G  16    CG   CD   OE1  OE2                                  
REMARK 470     ARG G  28    NH1  NH2                                            
REMARK 470     LEU G  34    CG   CD1  CD2                                       
REMARK 470     LYS G  35    CG   CD   CE   NZ                                   
REMARK 470     ARG G  36    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP G  37    CG   OD1  OD2                                       
REMARK 470     LYS G  38    CG   CD   CE   NZ                                   
REMARK 470     GLU G  40    CG   CD   OE1  OE2                                  
REMARK 470     THR G  41    OG1  CG2                                            
REMARK 470     ILE G  42    CG1  CG2  CD1                                       
REMARK 470     GLN G  43    CG   CD   OE1  NE2                                  
REMARK 470     GLY G  44    O                                                   
REMARK 470     LEU G  45    CG   CD1  CD2                                       
REMARK 470     ARG G  46    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASN G  48    CG   OD1  ND2                                       
REMARK 470     THR G  50    OG1  CG2                                            
REMARK 470     SER G  51    OG                                                  
REMARK 470     GLU G  54    CG   CD   OE1  OE2                                  
REMARK 470     THR G  55    OG1  CG2                                            
REMARK 470     CYS G  57    SG                                                  
REMARK 470     VAL G  59    CG1  CG2                                            
REMARK 470     ASP G  60    CG   OD1  OD2                                       
REMARK 470     LEU G  73    CG   CD1  CD2                                       
REMARK 470     ILE G  76    CG1  CG2  CD1                                       
REMARK 470     SER G  80    OG                                                  
REMARK 470     GLU G  82    CG   CD   OE1  OE2                                  
REMARK 470     TYR G  83    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     SER G  84    OG                                                  
REMARK 470     ASP G  85    CG   OD1  OD2                                       
REMARK 470     TYR G  86    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     SER G  87    OG                                                  
REMARK 470     CYS G  89    SG                                                  
REMARK 470     LYS G  91    CG   CD   CE   NZ                                   
REMARK 470     ILE G  94    CG1  CG2  CD1                                       
REMARK 470     GLU G  95    CG   CD   OE1  OE2                                  
REMARK 470     SER G 105    OG                                                  
REMARK 470     TYR G 130    OH                                                  
REMARK 470     ARG G 132    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG G 136    NH1  NH2                                            
REMARK 470     LYS G 145    CG   CD   CE   NZ                                   
REMARK 470     ARG G 147    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     TYR G 151    OH                                                  
REMARK 470     ASN G 172    CG   OD1  ND2                                       
REMARK 470     VAL G 173    CG1  CG2                                            
REMARK 470     TYR G 185    OH                                                  
REMARK 470     TYR G 227    OH                                                  
REMARK 470     ARG G 237    NH1  NH2                                            
REMARK 470     TYR G 252    OH                                                  
REMARK 470     GLU G 268    CG   CD   OE1  OE2                                  
REMARK 470     GLU G 269    CG   CD   OE1  OE2                                  
REMARK 470     TYR G 275    OH                                                  
REMARK 470     ASP H   2    CG   OD1  OD2                                       
REMARK 470     ASP H   3    CG   OD1  OD2                                       
REMARK 470     GLU H   5    CG   CD   OE1  OE2                                  
REMARK 470     ILE H   7    CG1  CG2  CD1                                       
REMARK 470     GLU H   8    CG   CD   OE1  OE2                                  
REMARK 470     TYR H   9    OH                                                  
REMARK 470     SER H  12    OG                                                  
REMARK 470     MET H  14    CG   SD   CE                                        
REMARK 470     LYS H  15    CG   CD   CE   NZ                                   
REMARK 470     GLU H  16    CG   CD   OE1  OE2                                  
REMARK 470     ARG H  28    NH1  NH2                                            
REMARK 470     LEU H  34    CG   CD1  CD2                                       
REMARK 470     LYS H  35    CG   CD   CE   NZ                                   
REMARK 470     ARG H  36    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP H  37    CG   OD1  OD2                                       
REMARK 470     LYS H  38    CG   CD   CE   NZ                                   
REMARK 470     GLU H  40    CG   CD   OE1  OE2                                  
REMARK 470     THR H  41    OG1  CG2                                            
REMARK 470     ILE H  42    CG1  CG2  CD1                                       
REMARK 470     GLN H  43    CG   CD   OE1  NE2                                  
REMARK 470     GLY H  44    O                                                   
REMARK 470     LEU H  45    CG   CD1  CD2                                       
REMARK 470     ARG H  46    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASN H  48    CG   OD1  ND2                                       
REMARK 470     THR H  50    OG1  CG2                                            
REMARK 470     SER H  51    OG                                                  
REMARK 470     GLU H  54    CG   CD   OE1  OE2                                  
REMARK 470     THR H  55    OG1  CG2                                            
REMARK 470     CYS H  57    SG                                                  
REMARK 470     VAL H  59    CG1  CG2                                            
REMARK 470     ASP H  60    CG   OD1  OD2                                       
REMARK 470     LEU H  73    CG   CD1  CD2                                       
REMARK 470     ILE H  76    CG1  CG2  CD1                                       
REMARK 470     SER H  80    OG                                                  
REMARK 470     GLU H  82    CG   CD   OE1  OE2                                  
REMARK 470     TYR H  83    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     SER H  84    OG                                                  
REMARK 470     ASP H  85    CG   OD1  OD2                                       
REMARK 470     TYR H  86    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     SER H  87    OG                                                  
REMARK 470     CYS H  89    SG                                                  
REMARK 470     LYS H  91    CG   CD   CE   NZ                                   
REMARK 470     ILE H  94    CG1  CG2  CD1                                       
REMARK 470     GLU H  95    CG   CD   OE1  OE2                                  
REMARK 470     SER H 105    OG                                                  
REMARK 470     TYR H 130    OH                                                  
REMARK 470     ARG H 132    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG H 136    NH1  NH2                                            
REMARK 470     LYS H 145    CG   CD   CE   NZ                                   
REMARK 470     ARG H 147    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     TYR H 151    OH                                                  
REMARK 470     ASN H 172    CG   OD1  ND2                                       
REMARK 470     VAL H 173    CG1  CG2                                            
REMARK 470     TYR H 185    OH                                                  
REMARK 470     TYR H 227    OH                                                  
REMARK 470     ARG H 237    NH1  NH2                                            
REMARK 470     TYR H 252    OH                                                  
REMARK 470     GLU H 268    CG   CD   OE1  OE2                                  
REMARK 470     GLU H 269    CG   CD   OE1  OE2                                  
REMARK 470     TYR H 275    OH                                                  
REMARK 470     LEU I  28    CG   CD1  CD2                                       
REMARK 470     PRO I  29    CG   CD                                             
REMARK 470     VAL I  30    CG1  CG2                                            
REMARK 470     ASN I  32    CG   OD1  ND2                                       
REMARK 470     LYS I  33    CG   CD   CE   NZ                                   
REMARK 470     PRO I  34    CG   CD                                             
REMARK 470     LEU I  35    CG   CD1  CD2                                       
REMARK 470     TRP I  37    CH2                                                 
REMARK 470     TYR I  38    OH                                                  
REMARK 470     ARG I  45    NH1  NH2                                            
REMARK 470     THR I  55    OG1  CG2                                            
REMARK 470     THR I  56    OG1  CG2                                            
REMARK 470     ARG I  57    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP I  58    CG   OD1  OD2                                       
REMARK 470     VAL I  59    CG1  CG2                                            
REMARK 470     GLN I  60    CG   CD   OE1  NE2                                  
REMARK 470     LYS I  61    CG   CD   CE   NZ                                   
REMARK 470     LEU I  63    CG   CD1  CD2                                       
REMARK 470     CYS I  64    SG                                                  
REMARK 470     GLU I  66    CG   CD   OE1  OE2                                  
REMARK 470     PHE I  67    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     LYS I  68    CG   CD   CE   NZ                                   
REMARK 470     MET I  69    CG   SD   CE                                        
REMARK 470     LYS I  70    CG   CD   CE   NZ                                   
REMARK 470     MET I  71    CG   SD   CE                                        
REMARK 470     LYS I  72    CG   CD   CE   NZ                                   
REMARK 470     PRO I  73    CG   CD                                             
REMARK 470     ASP I  74    CG   OD1  OD2                                       
REMARK 470     ASP I  80    CG   OD1  OD2                                       
REMARK 470     ASP I  81    CG   OD1  OD2                                       
REMARK 470     ASP I  83    CG   OD1  OD2                                       
REMARK 470     MET I  84    CG   SD   CE                                        
REMARK 470     ARG I  91    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     TYR I  92    OH                                                  
REMARK 470     TYR I  94    OH                                                  
REMARK 470     ASP I 107    CG   OD1  OD2                                       
REMARK 470     LEU I 108    CG   CD1  CD2                                       
REMARK 470     ASP I 111    CG   OD1  OD2                                       
REMARK 470     ARG I 122    NH1  NH2                                            
REMARK 470     TYR I 124    OH                                                  
REMARK 470     ARG I 133    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS I 134    CG   CD   CE   NZ                                   
REMARK 470     ARG I 155    NH1  NH2                                            
REMARK 470     ARG I 166    NH1  NH2                                            
REMARK 470     ASP I 175    CG   OD1  OD2                                       
REMARK 470     ASP I 177    CG   OD1  OD2                                       
REMARK 470     GLU I 178    CG   CD   OE1  OE2                                  
REMARK 470     GLU I 179    CG   CD   OE1  OE2                                  
REMARK 470     ARG I 192    NH1  NH2                                            
REMARK 470     ARG I 194    NH1  NH2                                            
REMARK 470     TYR I 205    OH                                                  
REMARK 470     TYR I 210    OH                                                  
REMARK 470     MET I 216    CG   SD   CE                                        
REMARK 470     GLU I 217    CG   CD   OE1  OE2                                  
REMARK 470     ASN I 218    CG   OD1  ND2                                       
REMARK 470     SER I 220    OG                                                  
REMARK 470     ILE I 221    CG1  CG2  CD1                                       
REMARK 470     THR I 222    OG1  CG2                                            
REMARK 470     SER I 223    OG                                                  
REMARK 470     ILE I 224    CG1  CG2  CD1                                       
REMARK 470     ARG I 225    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     SER I 226    OG                                                  
REMARK 470     GLU I 227    CG   CD   OE1  OE2                                  
REMARK 470     LEU I 228    CG   CD1  CD2                                       
REMARK 470     ILE I 229    CG1  CG2  CD1                                       
REMARK 470     PRO I 230    CG   CD                                             
REMARK 470     TYR I 231    OH                                                  
REMARK 470     LEU I 232    CG   CD1  CD2                                       
REMARK 470     VAL I 233    CG1  CG2                                            
REMARK 470     ARG I 234    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS I 235    CG   CD   CE   NZ                                   
REMARK 470     GLN I 236    CG   CD   OE1  NE2                                  
REMARK 470     PHE I 237    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     SER I 238    OG                                                  
REMARK 470     LEU I 258    CG   CD1  CD2                                       
REMARK 470     LYS I 259    CG   CD   CE   NZ                                   
REMARK 470     SER I 260    OG                                                  
REMARK 470     TYR I 264    OH                                                  
REMARK 470     LYS I 268    CG   CD   CE   NZ                                   
REMARK 470     GLU I 269    CG   CD   OE1  OE2                                  
REMARK 470     ASN I 271    CG   OD1  ND2                                       
REMARK 470     THR I 272    OG1  CG2                                            
REMARK 470     LEU I 273    CG   CD1  CD2                                       
REMARK 470     ASN I 274    CG   OD1  ND2                                       
REMARK 470     LEU I 275    CG   CD1  CD2                                       
REMARK 470     PRO I 277    CG   CD                                             
REMARK 470     TYR I 278    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     ASP I 279    CG   OD1  OD2                                       
REMARK 470     CYS I 281    SG                                                  
REMARK 470     TRP I 282    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
REMARK 470     TRP I 282    CZ3  CH2                                            
REMARK 470     ASN I 283    CG   OD1  ND2                                       
REMARK 470     CYS I 285    SG                                                  
REMARK 470     ARG I 286    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP I 288    CG   OD1  OD2                                       
REMARK 470     ARG I 289    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     TRP I 290    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
REMARK 470     TRP I 290    CZ3  CH2                                            
REMARK 470     GLU I 291    CG   CD   OE1  OE2                                  
REMARK 470     ASP I 292    CG   OD1  OD2                                       
REMARK 470     LEU I 293    CG   CD1  CD2                                       
REMARK 470     SER I 294    OG                                                  
REMARK 470     ARG I 295    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LEU J  28    CG   CD1  CD2                                       
REMARK 470     PRO J  29    CG   CD                                             
REMARK 470     VAL J  30    CG1  CG2                                            
REMARK 470     ASN J  32    CG   OD1  ND2                                       
REMARK 470     LYS J  33    CG   CD   CE   NZ                                   
REMARK 470     PRO J  34    CG   CD                                             
REMARK 470     LEU J  35    CG   CD1  CD2                                       
REMARK 470     TRP J  37    CH2                                                 
REMARK 470     TYR J  38    OH                                                  
REMARK 470     ARG J  45    NH1  NH2                                            
REMARK 470     THR J  55    OG1  CG2                                            
REMARK 470     THR J  56    OG1  CG2                                            
REMARK 470     ARG J  57    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP J  58    CG   OD1  OD2                                       
REMARK 470     VAL J  59    CG1  CG2                                            
REMARK 470     GLN J  60    CG   CD   OE1  NE2                                  
REMARK 470     LYS J  61    CG   CD   CE   NZ                                   
REMARK 470     LEU J  63    CG   CD1  CD2                                       
REMARK 470     CYS J  64    SG                                                  
REMARK 470     GLU J  66    CG   CD   OE1  OE2                                  
REMARK 470     PHE J  67    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     LYS J  68    CG   CD   CE   NZ                                   
REMARK 470     MET J  69    CG   SD   CE                                        
REMARK 470     LYS J  70    CG   CD   CE   NZ                                   
REMARK 470     MET J  71    CG   SD   CE                                        
REMARK 470     LYS J  72    CG   CD   CE   NZ                                   
REMARK 470     PRO J  73    CG   CD                                             
REMARK 470     ASP J  74    CG   OD1  OD2                                       
REMARK 470     ASP J  80    CG   OD1  OD2                                       
REMARK 470     ASP J  81    CG   OD1  OD2                                       
REMARK 470     ASP J  83    CG   OD1  OD2                                       
REMARK 470     MET J  84    CG   SD   CE                                        
REMARK 470     ARG J  91    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     TYR J  92    OH                                                  
REMARK 470     TYR J  94    OH                                                  
REMARK 470     ASP J 107    CG   OD1  OD2                                       
REMARK 470     LEU J 108    CG   CD1  CD2                                       
REMARK 470     ASP J 111    CG   OD1  OD2                                       
REMARK 470     ARG J 122    NH1  NH2                                            
REMARK 470     TYR J 124    OH                                                  
REMARK 470     ARG J 133    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS J 134    CG   CD   CE   NZ                                   
REMARK 470     ARG J 155    NH1  NH2                                            
REMARK 470     ARG J 166    NH1  NH2                                            
REMARK 470     ASP J 175    CG   OD1  OD2                                       
REMARK 470     ASP J 177    CG   OD1  OD2                                       
REMARK 470     GLU J 178    CG   CD   OE1  OE2                                  
REMARK 470     GLU J 179    CG   CD   OE1  OE2                                  
REMARK 470     ARG J 192    NH1  NH2                                            
REMARK 470     ARG J 194    NH1  NH2                                            
REMARK 470     TYR J 205    OH                                                  
REMARK 470     TYR J 210    OH                                                  
REMARK 470     MET J 216    CG   SD   CE                                        
REMARK 470     GLU J 217    CG   CD   OE1  OE2                                  
REMARK 470     ASN J 218    CG   OD1  ND2                                       
REMARK 470     SER J 220    OG                                                  
REMARK 470     ILE J 221    CG1  CG2  CD1                                       
REMARK 470     THR J 222    OG1  CG2                                            
REMARK 470     SER J 223    OG                                                  
REMARK 470     ILE J 224    CG1  CG2  CD1                                       
REMARK 470     ARG J 225    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     SER J 226    OG                                                  
REMARK 470     GLU J 227    CG   CD   OE1  OE2                                  
REMARK 470     LEU J 228    CG   CD1  CD2                                       
REMARK 470     ILE J 229    CG1  CG2  CD1                                       
REMARK 470     PRO J 230    CG   CD                                             
REMARK 470     TYR J 231    OH                                                  
REMARK 470     LEU J 232    CG   CD1  CD2                                       
REMARK 470     VAL J 233    CG1  CG2                                            
REMARK 470     ARG J 234    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS J 235    CG   CD   CE   NZ                                   
REMARK 470     GLN J 236    CG   CD   OE1  NE2                                  
REMARK 470     PHE J 237    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     SER J 238    OG                                                  
REMARK 470     LEU J 258    CG   CD1  CD2                                       
REMARK 470     LYS J 259    CG   CD   CE   NZ                                   
REMARK 470     SER J 260    OG                                                  
REMARK 470     TYR J 264    OH                                                  
REMARK 470     LYS J 268    CG   CD   CE   NZ                                   
REMARK 470     GLU J 269    CG   CD   OE1  OE2                                  
REMARK 470     ASN J 271    CG   OD1  ND2                                       
REMARK 470     THR J 272    OG1  CG2                                            
REMARK 470     LEU J 273    CG   CD1  CD2                                       
REMARK 470     ASN J 274    CG   OD1  ND2                                       
REMARK 470     LEU J 275    CG   CD1  CD2                                       
REMARK 470     PRO J 277    CG   CD                                             
REMARK 470     TYR J 278    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     ASP J 279    CG   OD1  OD2                                       
REMARK 470     CYS J 281    SG                                                  
REMARK 470     TRP J 282    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
REMARK 470     TRP J 282    CZ3  CH2                                            
REMARK 470     ASN J 283    CG   OD1  ND2                                       
REMARK 470     CYS J 285    SG                                                  
REMARK 470     ARG J 286    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP J 288    CG   OD1  OD2                                       
REMARK 470     ARG J 289    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     TRP J 290    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
REMARK 470     TRP J 290    CZ3  CH2                                            
REMARK 470     GLU J 291    CG   CD   OE1  OE2                                  
REMARK 470     ASP J 292    CG   OD1  OD2                                       
REMARK 470     LEU J 293    CG   CD1  CD2                                       
REMARK 470     SER J 294    OG                                                  
REMARK 470     ARG J 295    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     CYS L   5    SG                                                  
REMARK 470     ARG L   6    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     PHE L   7    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     TYR L   8    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     GLN L   9    CG   CD   OE1  NE2                                  
REMARK 470     HIS L  10    CG   ND1  CD2  CE1  NE2                             
REMARK 470     LYS L  11    CG   CD   CE   NZ                                   
REMARK 470     PHE L  12    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     PRO L  13    CG   CD                                             
REMARK 470     GLU L  14    CG   CD   OE1  OE2                                  
REMARK 470     VAL L  15    CG1  CG2                                            
REMARK 470     GLU L  16    CG   CD   OE1  OE2                                  
REMARK 470     ASP L  17    CG   OD1  OD2                                       
REMARK 470     VAL L  18    CG1  CG2                                            
REMARK 470     VAL L  19    CG1  CG2                                            
REMARK 470     MET L  20    CG   SD   CE                                        
REMARK 470     VAL L  21    CG1  CG2                                            
REMARK 470     ASN L  22    CG   OD1  ND2                                       
REMARK 470     VAL L  23    CG1  CG2                                            
REMARK 470     ARG L  24    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     SER L  25    OG                                                  
REMARK 470     ILE L  26    CG1  CG2  CD1                                       
REMARK 470     GLU L  28    CB   CG   CD   OE1  OE2                             
REMARK 470     MET L  29    CG   SD   CE                                        
REMARK 470     TYR L  32    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     VAL L  33    CG1  CG2                                            
REMARK 470     SER L  34    OG                                                  
REMARK 470     LEU L  35    CG   CD1  CD2                                       
REMARK 470     LEU L  36    CG   CD1  CD2                                       
REMARK 470     GLU L  37    CG   CD   OE1  OE2                                  
REMARK 470     TYR L  38    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     ASN L  39    CG   OD1  ND2                                       
REMARK 470     ASN L  40    CG   OD1  ND2                                       
REMARK 470     ILE L  41    CG1  CG2  CD1                                       
REMARK 470     GLU L  42    CG   CD   OE1  OE2                                  
REMARK 470     LEU L  46    CG   CD1  CD2                                       
REMARK 470     SER L  48    OG                                                  
REMARK 470     GLU L  49    CG   CD   OE1  OE2                                  
REMARK 470     ARG L  54    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ILE L  55    CG1  CG2  CD1                                       
REMARK 470     ARG L  56    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     SER L  57    OG                                                  
REMARK 470     ILE L  58    CG1  CG2  CD1                                       
REMARK 470     ASN L  59    CG   OD1  ND2                                       
REMARK 470     LYS L  60    CG   CD   CE   NZ                                   
REMARK 470     LEU L  61    CG   CD1  CD2                                       
REMARK 470     ILE L  64    CG1  CG2  CD1                                       
REMARK 470     CYS L  69    SG                                                  
REMARK 470     VAL L  70    CG1  CG2                                            
REMARK 470     VAL L  71    CG1  CG2                                            
REMARK 470     VAL L  72    CG1  CG2                                            
REMARK 470     ILE L  73    CG1  CG2  CD1                                       
REMARK 470     ARG L  74    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     VAL L  75    CG1  CG2                                            
REMARK 470     ASP L  76    CG   OD1  OD2                                       
REMARK 470     LYS L  77    CG   CD   CE   NZ                                   
REMARK 470     GLU L  78    CG   CD   OE1  OE2                                  
REMARK 470     LYS L  79    CG   CD   CE   NZ                                   
REMARK 470     TYR L  81    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     ILE L  82    CG1  CG2  CD1                                       
REMARK 470     ASP L  83    CG   OD1  OD2                                       
REMARK 470     LEU L  84    CG   CD1  CD2                                       
REMARK 470     SER L  85    OG                                                  
REMARK 470     LYS L  86    CG   CD   CE   NZ                                   
REMARK 470     ARG L  88    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     VAL L  89    CG1  CG2                                            
REMARK 470     SER L  90    OG                                                  
REMARK 470     PRO L  91    CG   CD                                             
REMARK 470     GLU L  92    CG   CD   OE1  OE2                                  
REMARK 470     GLU L  93    CG   CD   OE1  OE2                                  
REMARK 470     ILE L  95    CG1  CG2  CD1                                       
REMARK 470     LYS L  96    CG   CD   CE   NZ                                   
REMARK 470     CYS L  97    SG                                                  
REMARK 470     GLU L  98    CG   CD   OE1  OE2                                  
REMARK 470     ASP L  99    CG   OD1  OD2                                       
REMARK 470     LYS L 100    CG   CD   CE   NZ                                   
REMARK 470     PHE L 101    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     THR L 102    OG1  CG2                                            
REMARK 470     LYS L 103    CG   CD   CE   NZ                                   
REMARK 470     SER L 104    OG                                                  
REMARK 470     LYS L 105    CG   CD   CE   NZ                                   
REMARK 470     THR L 106    OG1  CG2                                            
REMARK 470     VAL L 107    CG1  CG2                                            
REMARK 470     TYR L 108    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     SER L 109    OG                                                  
REMARK 470     ILE L 110    CG1  CG2  CD1                                       
REMARK 470     LEU L 111    CG   CD1  CD2                                       
REMARK 470     ARG L 112    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     HIS L 113    CG   ND1  CD2  CE1  NE2                             
REMARK 470     VAL L 114    CG1  CG2                                            
REMARK 470     GLU L 116    CG   CD   OE1  OE2                                  
REMARK 470     VAL L 117    CG1  CG2                                            
REMARK 470     LEU L 118    CG   CD1  CD2                                       
REMARK 470     GLU L 119    CG   CD   OE1  OE2                                  
REMARK 470     TYR L 120    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     THR L 121    OG1  CG2                                            
REMARK 470     LYS L 122    CG   CD   CE   NZ                                   
REMARK 470     ASP L 123    CG   OD1  OD2                                       
REMARK 470     GLU L 124    CG   CD   OE1  OE2                                  
REMARK 470     GLN L 125    CG   CD   OE1  NE2                                  
REMARK 470     LEU L 126    CG   CD1  CD2                                       
REMARK 470     GLU L 127    CG   CD   OE1  OE2                                  
REMARK 470     SER L 128    OG                                                  
REMARK 470     LEU L 129    CG   CD1  CD2                                       
REMARK 470     PHE L 130    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     GLN L 131    CG   CD   OE1  NE2                                  
REMARK 470     ARG L 132    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     THR L 133    OG1  CG2                                            
REMARK 470     TRP L 135    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
REMARK 470     TRP L 135    CZ3  CH2                                            
REMARK 470     VAL L 136    CG1  CG2                                            
REMARK 470     PHE L 137    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ASP L 138    CG   OD1  OD2                                       
REMARK 470     ASP L 139    CG   OD1  OD2                                       
REMARK 470     LYS L 140    CG   CD   CE   NZ                                   
REMARK 470     TYR L 141    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     LYS L 142    CG   CD   CE   NZ                                   
REMARK 470     ARG L 143    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     PRO L 144    CG   CD                                             
REMARK 470     TYR L 146    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     TYR L 149    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     ASP L 150    CG   OD1  OD2                                       
REMARK 470     PHE L 152    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     LYS L 153    CG   CD   CE   NZ                                   
REMARK 470     HIS L 154    CG   ND1  CD2  CE1  NE2                             
REMARK 470     VAL L 156    CG1  CG2                                            
REMARK 470     SER L 157    OG                                                  
REMARK 470     ASP L 158    CG   OD1  OD2                                       
REMARK 470     PRO L 159    CG   CD                                             
REMARK 470     SER L 160    OG                                                  
REMARK 470     ILE L 161    CG1  CG2  CD1                                       
REMARK 470     LEU L 162    CG   CD1  CD2                                       
REMARK 470     ASP L 163    CG   OD1  OD2                                       
REMARK 470     SER L 164    OG                                                  
REMARK 470     LEU L 165    CG   CD1  CD2                                       
REMARK 470     ASP L 166    CG   OD1  OD2                                       
REMARK 470     LEU L 167    CG   CD1  CD2                                       
REMARK 470     ASN L 168    CG   OD1  ND2                                       
REMARK 470     GLU L 169    CG   CD   OE1  OE2                                  
REMARK 470     ASP L 170    CG   OD1  OD2                                       
REMARK 470     GLU L 171    CG   CD   OE1  OE2                                  
REMARK 470     ARG L 172    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU L 173    CG   CD   OE1  OE2                                  
REMARK 470     VAL L 174    CG1  CG2                                            
REMARK 470     LEU L 175    CG   CD1  CD2                                       
REMARK 470     ILE L 176    CG1  CG2  CD1                                       
REMARK 470     ASN L 177    CG   OD1  ND2                                       
REMARK 470     ASN L 178    CG   OD1  ND2                                       
REMARK 470     ILE L 179    CG1  CG2  CD1                                       
REMARK 470     ASN L 180    CG   OD1  ND2                                       
REMARK 470     CYS M   5    SG                                                  
REMARK 470     ARG M   6    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     PHE M   7    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     TYR M   8    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     GLN M   9    CG   CD   OE1  NE2                                  
REMARK 470     HIS M  10    CG   ND1  CD2  CE1  NE2                             
REMARK 470     LYS M  11    CG   CD   CE   NZ                                   
REMARK 470     PHE M  12    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     PRO M  13    CG   CD                                             
REMARK 470     GLU M  14    CG   CD   OE1  OE2                                  
REMARK 470     VAL M  15    CG1  CG2                                            
REMARK 470     GLU M  16    CG   CD   OE1  OE2                                  
REMARK 470     ASP M  17    CG   OD1  OD2                                       
REMARK 470     VAL M  18    CG1  CG2                                            
REMARK 470     VAL M  19    CG1  CG2                                            
REMARK 470     MET M  20    CG   SD   CE                                        
REMARK 470     VAL M  21    CG1  CG2                                            
REMARK 470     ASN M  22    CG   OD1  ND2                                       
REMARK 470     VAL M  23    CG1  CG2                                            
REMARK 470     ARG M  24    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     SER M  25    OG                                                  
REMARK 470     ILE M  26    CG1  CG2  CD1                                       
REMARK 470     GLU M  28    CB   CG   CD   OE1  OE2                             
REMARK 470     MET M  29    CG   SD   CE                                        
REMARK 470     TYR M  32    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     VAL M  33    CG1  CG2                                            
REMARK 470     SER M  34    OG                                                  
REMARK 470     LEU M  35    CG   CD1  CD2                                       
REMARK 470     LEU M  36    CG   CD1  CD2                                       
REMARK 470     GLU M  37    CG   CD   OE1  OE2                                  
REMARK 470     TYR M  38    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     ASN M  39    CG   OD1  ND2                                       
REMARK 470     ASN M  40    CG   OD1  ND2                                       
REMARK 470     ILE M  41    CG1  CG2  CD1                                       
REMARK 470     GLU M  42    CG   CD   OE1  OE2                                  
REMARK 470     LEU M  46    CG   CD1  CD2                                       
REMARK 470     SER M  48    OG                                                  
REMARK 470     GLU M  49    CG   CD   OE1  OE2                                  
REMARK 470     ARG M  54    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ILE M  55    CG1  CG2  CD1                                       
REMARK 470     ARG M  56    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     SER M  57    OG                                                  
REMARK 470     ILE M  58    CG1  CG2  CD1                                       
REMARK 470     ASN M  59    CG   OD1  ND2                                       
REMARK 470     LYS M  60    CG   CD   CE   NZ                                   
REMARK 470     LEU M  61    CG   CD1  CD2                                       
REMARK 470     ILE M  64    CG1  CG2  CD1                                       
REMARK 470     CYS M  69    SG                                                  
REMARK 470     VAL M  70    CG1  CG2                                            
REMARK 470     VAL M  71    CG1  CG2                                            
REMARK 470     VAL M  72    CG1  CG2                                            
REMARK 470     ILE M  73    CG1  CG2  CD1                                       
REMARK 470     ARG M  74    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     VAL M  75    CG1  CG2                                            
REMARK 470     ASP M  76    CG   OD1  OD2                                       
REMARK 470     LYS M  77    CG   CD   CE   NZ                                   
REMARK 470     GLU M  78    CG   CD   OE1  OE2                                  
REMARK 470     LYS M  79    CG   CD   CE   NZ                                   
REMARK 470     TYR M  81    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     ILE M  82    CG1  CG2  CD1                                       
REMARK 470     ASP M  83    CG   OD1  OD2                                       
REMARK 470     LEU M  84    CG   CD1  CD2                                       
REMARK 470     SER M  85    OG                                                  
REMARK 470     LYS M  86    CG   CD   CE   NZ                                   
REMARK 470     ARG M  88    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     VAL M  89    CG1  CG2                                            
REMARK 470     SER M  90    OG                                                  
REMARK 470     PRO M  91    CG   CD                                             
REMARK 470     GLU M  92    CG   CD   OE1  OE2                                  
REMARK 470     GLU M  93    CG   CD   OE1  OE2                                  
REMARK 470     ILE M  95    CG1  CG2  CD1                                       
REMARK 470     LYS M  96    CG   CD   CE   NZ                                   
REMARK 470     CYS M  97    SG                                                  
REMARK 470     GLU M  98    CG   CD   OE1  OE2                                  
REMARK 470     ASP M  99    CG   OD1  OD2                                       
REMARK 470     LYS M 100    CG   CD   CE   NZ                                   
REMARK 470     PHE M 101    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     THR M 102    OG1  CG2                                            
REMARK 470     LYS M 103    CG   CD   CE   NZ                                   
REMARK 470     SER M 104    OG                                                  
REMARK 470     LYS M 105    CG   CD   CE   NZ                                   
REMARK 470     THR M 106    OG1  CG2                                            
REMARK 470     VAL M 107    CG1  CG2                                            
REMARK 470     TYR M 108    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     SER M 109    OG                                                  
REMARK 470     ILE M 110    CG1  CG2  CD1                                       
REMARK 470     LEU M 111    CG   CD1  CD2                                       
REMARK 470     ARG M 112    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     HIS M 113    CG   ND1  CD2  CE1  NE2                             
REMARK 470     VAL M 114    CG1  CG2                                            
REMARK 470     GLU M 116    CG   CD   OE1  OE2                                  
REMARK 470     VAL M 117    CG1  CG2                                            
REMARK 470     LEU M 118    CG   CD1  CD2                                       
REMARK 470     GLU M 119    CG   CD   OE1  OE2                                  
REMARK 470     TYR M 120    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     THR M 121    OG1  CG2                                            
REMARK 470     LYS M 122    CG   CD   CE   NZ                                   
REMARK 470     ASP M 123    CG   OD1  OD2                                       
REMARK 470     GLU M 124    CG   CD   OE1  OE2                                  
REMARK 470     GLN M 125    CG   CD   OE1  NE2                                  
REMARK 470     LEU M 126    CG   CD1  CD2                                       
REMARK 470     GLU M 127    CG   CD   OE1  OE2                                  
REMARK 470     SER M 128    OG                                                  
REMARK 470     LEU M 129    CG   CD1  CD2                                       
REMARK 470     PHE M 130    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     GLN M 131    CG   CD   OE1  NE2                                  
REMARK 470     ARG M 132    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     THR M 133    OG1  CG2                                            
REMARK 470     TRP M 135    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
REMARK 470     TRP M 135    CZ3  CH2                                            
REMARK 470     VAL M 136    CG1  CG2                                            
REMARK 470     PHE M 137    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ASP M 138    CG   OD1  OD2                                       
REMARK 470     ASP M 139    CG   OD1  OD2                                       
REMARK 470     LYS M 140    CG   CD   CE   NZ                                   
REMARK 470     TYR M 141    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     LYS M 142    CG   CD   CE   NZ                                   
REMARK 470     ARG M 143    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     PRO M 144    CG   CD                                             
REMARK 470     TYR M 146    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     TYR M 149    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     ASP M 150    CG   OD1  OD2                                       
REMARK 470     PHE M 152    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     LYS M 153    CG   CD   CE   NZ                                   
REMARK 470     HIS M 154    CG   ND1  CD2  CE1  NE2                             
REMARK 470     VAL M 156    CG1  CG2                                            
REMARK 470     SER M 157    OG                                                  
REMARK 470     ASP M 158    CG   OD1  OD2                                       
REMARK 470     PRO M 159    CG   CD                                             
REMARK 470     SER M 160    OG                                                  
REMARK 470     ILE M 161    CG1  CG2  CD1                                       
REMARK 470     LEU M 162    CG   CD1  CD2                                       
REMARK 470     ASP M 163    CG   OD1  OD2                                       
REMARK 470     SER M 164    OG                                                  
REMARK 470     LEU M 165    CG   CD1  CD2                                       
REMARK 470     ASP M 166    CG   OD1  OD2                                       
REMARK 470     LEU M 167    CG   CD1  CD2                                       
REMARK 470     ASN M 168    CG   OD1  ND2                                       
REMARK 470     GLU M 169    CG   CD   OE1  OE2                                  
REMARK 470     ASP M 170    CG   OD1  OD2                                       
REMARK 470     GLU M 171    CG   CD   OE1  OE2                                  
REMARK 470     ARG M 172    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU M 173    CG   CD   OE1  OE2                                  
REMARK 470     VAL M 174    CG1  CG2                                            
REMARK 470     LEU M 175    CG   CD1  CD2                                       
REMARK 470     ILE M 176    CG1  CG2  CD1                                       
REMARK 470     ASN M 177    CG   OD1  ND2                                       
REMARK 470     ASN M 178    CG   OD1  ND2                                       
REMARK 470     ILE M 179    CG1  CG2  CD1                                       
REMARK 470     ASN M 180    CG   OD1  ND2                                       
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   OE1  GLU D   193     NE2  HIS D   201              2.19            
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    PRO A  58       37.46    -94.12                                   
REMARK 500    ASP A 147       65.99     60.74                                   
REMARK 500    SER A 301      -30.53   -133.99                                   
REMARK 500    SER A 433       70.42     60.14                                   
REMARK 500    PRO B  58       37.49    -94.24                                   
REMARK 500    ASP B 147       66.00     60.73                                   
REMARK 500    SER B 301      -30.47   -134.04                                   
REMARK 500    SER B 433       70.48     60.12                                   
REMARK 500    GLU C 282       19.20     59.08                                   
REMARK 500    ASP C 283       19.31     55.42                                   
REMARK 500    SER C 284       52.60    -94.13                                   
REMARK 500    PRO D  28     -166.79    -79.21                                   
REMARK 500    ASP E 239       35.57    -98.38                                   
REMARK 500    ASN E 245       42.01     36.09                                   
REMARK 500    ALA E 451       30.60    -94.79                                   
REMARK 500    ASN E 475       64.34   -101.09                                   
REMARK 500    ASP E 498      -61.54    -93.93                                   
REMARK 500    ASP F 239       35.53    -98.37                                   
REMARK 500    ASN F 245       42.03     36.09                                   
REMARK 500    ALA F 451       30.68    -94.88                                   
REMARK 500    ASN F 475       64.28   -101.00                                   
REMARK 500    ASP F 498      -61.56    -93.89                                   
REMARK 500    ASP G   3      -39.53     71.68                                   
REMARK 500    LYS G  38       50.30     71.80                                   
REMARK 500    THR G  41      114.60   -164.26                                   
REMARK 500    TYR G  86      -12.10     72.59                                   
REMARK 500    SER G 155       70.19     61.78                                   
REMARK 500    ASP H   3      -39.51     71.66                                   
REMARK 500    LYS H  38       50.32     71.80                                   
REMARK 500    THR H  41      114.58   -164.34                                   
REMARK 500    TYR H  86      -12.02     72.60                                   
REMARK 500    SER H 155       70.14     61.83                                   
REMARK 500    LYS I  61       52.82    -92.37                                   
REMARK 500    LYS J  61       52.85    -92.37                                   
REMARK 500    ASN L  59       50.40     37.92                                   
REMARK 500    ARG L  66      147.24   -174.56                                   
REMARK 500    ASN M  59       50.36     37.95                                   
REMARK 500    ARG M  66      147.27   -174.58                                   
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: EMD-0664   RELATED DB: EMDB                              
REMARK 900 ELECTRON CRYO-MICROSCOPY OF THE EUKARYOTIC TRANSLATION INITIATION    
REMARK 900 FACTOR 2B BOUND TO EUKARYOTIC TRANSLATION INITIATION FACTOR 2 FROM   
REMARK 900 HOMO SAPIENS                                                         
DBREF  6O9Z A    1   721  UNP    Q13144   EI2BE_HUMAN      1    721             
DBREF  6O9Z B    1   721  UNP    Q13144   EI2BE_HUMAN      1    721             
DBREF  6O9Z C    2   351  UNP    P49770   EI2BB_HUMAN      2    351             
DBREF  6O9Z D    2   351  UNP    P49770   EI2BB_HUMAN      2    351             
DBREF  6O9Z E    1   523  UNP    Q9UI10   EI2BD_HUMAN      1    523             
DBREF  6O9Z F    1   523  UNP    Q9UI10   EI2BD_HUMAN      1    523             
DBREF  6O9Z G    1   305  UNP    Q14232   EI2BA_HUMAN      1    305             
DBREF  6O9Z H    1   305  UNP    Q14232   EI2BA_HUMAN      1    305             
DBREF  6O9Z I    1   452  UNP    Q9NR50   EI2BG_HUMAN      1    452             
DBREF  6O9Z J    1   452  UNP    Q9NR50   EI2BG_HUMAN      1    452             
DBREF  6O9Z L    1   314  UNP    P05198   IF2A_HUMAN       2    315             
DBREF  6O9Z M    1   314  UNP    P05198   IF2A_HUMAN       2    315             
SEQADV 6O9Z VAL A  587  UNP  Q13144    ILE   587 CONFLICT                       
SEQADV 6O9Z VAL B  587  UNP  Q13144    ILE   587 CONFLICT                       
SEQADV 6O9Z MET C  -16  UNP  P49770              INITIATING METHIONINE          
SEQADV 6O9Z HIS C  -15  UNP  P49770              EXPRESSION TAG                 
SEQADV 6O9Z HIS C  -14  UNP  P49770              EXPRESSION TAG                 
SEQADV 6O9Z HIS C  -13  UNP  P49770              EXPRESSION TAG                 
SEQADV 6O9Z HIS C  -12  UNP  P49770              EXPRESSION TAG                 
SEQADV 6O9Z HIS C  -11  UNP  P49770              EXPRESSION TAG                 
SEQADV 6O9Z HIS C  -10  UNP  P49770              EXPRESSION TAG                 
SEQADV 6O9Z GLY C   -9  UNP  P49770              EXPRESSION TAG                 
SEQADV 6O9Z GLY C   -8  UNP  P49770              EXPRESSION TAG                 
SEQADV 6O9Z GLY C   -7  UNP  P49770              EXPRESSION TAG                 
SEQADV 6O9Z SER C   -6  UNP  P49770              EXPRESSION TAG                 
SEQADV 6O9Z GLU C   -5  UNP  P49770              EXPRESSION TAG                 
SEQADV 6O9Z ASN C   -4  UNP  P49770              EXPRESSION TAG                 
SEQADV 6O9Z LEU C   -3  UNP  P49770              EXPRESSION TAG                 
SEQADV 6O9Z TYR C   -2  UNP  P49770              EXPRESSION TAG                 
SEQADV 6O9Z PHE C   -1  UNP  P49770              EXPRESSION TAG                 
SEQADV 6O9Z GLN C    0  UNP  P49770              EXPRESSION TAG                 
SEQADV 6O9Z SER C    1  UNP  P49770              EXPRESSION TAG                 
SEQADV 6O9Z MET D  -16  UNP  P49770              INITIATING METHIONINE          
SEQADV 6O9Z HIS D  -15  UNP  P49770              EXPRESSION TAG                 
SEQADV 6O9Z HIS D  -14  UNP  P49770              EXPRESSION TAG                 
SEQADV 6O9Z HIS D  -13  UNP  P49770              EXPRESSION TAG                 
SEQADV 6O9Z HIS D  -12  UNP  P49770              EXPRESSION TAG                 
SEQADV 6O9Z HIS D  -11  UNP  P49770              EXPRESSION TAG                 
SEQADV 6O9Z HIS D  -10  UNP  P49770              EXPRESSION TAG                 
SEQADV 6O9Z GLY D   -9  UNP  P49770              EXPRESSION TAG                 
SEQADV 6O9Z GLY D   -8  UNP  P49770              EXPRESSION TAG                 
SEQADV 6O9Z GLY D   -7  UNP  P49770              EXPRESSION TAG                 
SEQADV 6O9Z SER D   -6  UNP  P49770              EXPRESSION TAG                 
SEQADV 6O9Z GLU D   -5  UNP  P49770              EXPRESSION TAG                 
SEQADV 6O9Z ASN D   -4  UNP  P49770              EXPRESSION TAG                 
SEQADV 6O9Z LEU D   -3  UNP  P49770              EXPRESSION TAG                 
SEQADV 6O9Z TYR D   -2  UNP  P49770              EXPRESSION TAG                 
SEQADV 6O9Z PHE D   -1  UNP  P49770              EXPRESSION TAG                 
SEQADV 6O9Z GLN D    0  UNP  P49770              EXPRESSION TAG                 
SEQADV 6O9Z SER D    1  UNP  P49770              EXPRESSION TAG                 
SEQADV 6O9Z MET L   -8  UNP  P05198              INITIATING METHIONINE          
SEQADV 6O9Z ASP L   -7  UNP  P05198              EXPRESSION TAG                 
SEQADV 6O9Z TYR L   -6  UNP  P05198              EXPRESSION TAG                 
SEQADV 6O9Z LYS L   -5  UNP  P05198              EXPRESSION TAG                 
SEQADV 6O9Z ASP L   -4  UNP  P05198              EXPRESSION TAG                 
SEQADV 6O9Z ASP L   -3  UNP  P05198              EXPRESSION TAG                 
SEQADV 6O9Z ASP L   -2  UNP  P05198              EXPRESSION TAG                 
SEQADV 6O9Z ASP L   -1  UNP  P05198              EXPRESSION TAG                 
SEQADV 6O9Z LYS L    0  UNP  P05198              EXPRESSION TAG                 
SEQADV 6O9Z MET M   -8  UNP  P05198              INITIATING METHIONINE          
SEQADV 6O9Z ASP M   -7  UNP  P05198              EXPRESSION TAG                 
SEQADV 6O9Z TYR M   -6  UNP  P05198              EXPRESSION TAG                 
SEQADV 6O9Z LYS M   -5  UNP  P05198              EXPRESSION TAG                 
SEQADV 6O9Z ASP M   -4  UNP  P05198              EXPRESSION TAG                 
SEQADV 6O9Z ASP M   -3  UNP  P05198              EXPRESSION TAG                 
SEQADV 6O9Z ASP M   -2  UNP  P05198              EXPRESSION TAG                 
SEQADV 6O9Z ASP M   -1  UNP  P05198              EXPRESSION TAG                 
SEQADV 6O9Z LYS M    0  UNP  P05198              EXPRESSION TAG                 
SEQRES   1 A  721  MET ALA ALA PRO VAL VAL ALA PRO PRO GLY VAL VAL VAL          
SEQRES   2 A  721  SER ARG ALA ASN LYS ARG SER GLY ALA GLY PRO GLY GLY          
SEQRES   3 A  721  SER GLY GLY GLY GLY ALA ARG GLY ALA GLU GLU GLU PRO          
SEQRES   4 A  721  PRO PRO PRO LEU GLN ALA VAL LEU VAL ALA ASP SER PHE          
SEQRES   5 A  721  ASP ARG ARG PHE PHE PRO ILE SER LYS ASP GLN PRO ARG          
SEQRES   6 A  721  VAL LEU LEU PRO LEU ALA ASN VAL ALA LEU ILE ASP TYR          
SEQRES   7 A  721  THR LEU GLU PHE LEU THR ALA THR GLY VAL GLN GLU THR          
SEQRES   8 A  721  PHE VAL PHE CYS CYS TRP LYS ALA ALA GLN ILE LYS GLU          
SEQRES   9 A  721  HIS LEU LEU LYS SER LYS TRP CYS ARG PRO THR SER LEU          
SEQRES  10 A  721  ASN VAL VAL ARG ILE ILE THR SER GLU LEU TYR ARG SER          
SEQRES  11 A  721  LEU GLY ASP VAL LEU ARG ASP VAL ASP ALA LYS ALA LEU          
SEQRES  12 A  721  VAL ARG SER ASP PHE LEU LEU VAL TYR GLY ASP VAL ILE          
SEQRES  13 A  721  SER ASN ILE ASN ILE THR ARG ALA LEU GLU GLU HIS ARG          
SEQRES  14 A  721  LEU ARG ARG LYS LEU GLU LYS ASN VAL SER VAL MET THR          
SEQRES  15 A  721  MET ILE PHE LYS GLU SER SER PRO SER HIS PRO THR ARG          
SEQRES  16 A  721  CYS HIS GLU ASP ASN VAL VAL VAL ALA VAL ASP SER THR          
SEQRES  17 A  721  THR ASN ARG VAL LEU HIS PHE GLN LYS THR GLN GLY LEU          
SEQRES  18 A  721  ARG ARG PHE ALA PHE PRO LEU SER LEU PHE GLN GLY SER          
SEQRES  19 A  721  SER ASP GLY VAL GLU VAL ARG TYR ASP LEU LEU ASP CYS          
SEQRES  20 A  721  HIS ILE SER ILE CYS SER PRO GLN VAL ALA GLN LEU PHE          
SEQRES  21 A  721  THR ASP ASN PHE ASP TYR GLN THR ARG ASP ASP PHE VAL          
SEQRES  22 A  721  ARG GLY LEU LEU VAL ASN GLU GLU ILE LEU GLY ASN GLN          
SEQRES  23 A  721  ILE HIS MET HIS VAL THR ALA LYS GLU TYR GLY ALA ARG          
SEQRES  24 A  721  VAL SER ASN LEU HIS MET TYR SER ALA VAL CYS ALA ASP          
SEQRES  25 A  721  VAL ILE ARG ARG TRP VAL TYR PRO LEU THR PRO GLU ALA          
SEQRES  26 A  721  ASN PHE THR ASP SER THR THR GLN SER CYS THR HIS SER          
SEQRES  27 A  721  ARG HIS ASN ILE TYR ARG GLY PRO GLU VAL SER LEU GLY          
SEQRES  28 A  721  HIS GLY SER ILE LEU GLU GLU ASN VAL LEU LEU GLY SER          
SEQRES  29 A  721  GLY THR VAL ILE GLY SER ASN CYS PHE ILE THR ASN SER          
SEQRES  30 A  721  VAL ILE GLY PRO GLY CYS HIS ILE GLY ASP ASN VAL VAL          
SEQRES  31 A  721  LEU ASP GLN THR TYR LEU TRP GLN GLY VAL ARG VAL ALA          
SEQRES  32 A  721  ALA GLY ALA GLN ILE HIS GLN SER LEU LEU CYS ASP ASN          
SEQRES  33 A  721  ALA GLU VAL LYS GLU ARG VAL THR LEU LYS PRO ARG SER          
SEQRES  34 A  721  VAL LEU THR SER GLN VAL VAL VAL GLY PRO ASN ILE THR          
SEQRES  35 A  721  LEU PRO GLU GLY SER VAL ILE SER LEU HIS PRO PRO ASP          
SEQRES  36 A  721  ALA GLU GLU ASP GLU ASP ASP GLY GLU PHE SER ASP ASP          
SEQRES  37 A  721  SER GLY ALA ASP GLN GLU LYS ASP LYS VAL LYS MET LYS          
SEQRES  38 A  721  GLY TYR ASN PRO ALA GLU VAL GLY ALA ALA GLY LYS GLY          
SEQRES  39 A  721  TYR LEU TRP LYS ALA ALA GLY MET ASN MET GLU GLU GLU          
SEQRES  40 A  721  GLU GLU LEU GLN GLN ASN LEU TRP GLY LEU LYS ILE ASN          
SEQRES  41 A  721  MET GLU GLU GLU SER GLU SER GLU SER GLU GLN SER MET          
SEQRES  42 A  721  ASP SER GLU GLU PRO ASP SER ARG GLY GLY SER PRO GLN          
SEQRES  43 A  721  MET ASP ASP ILE LYS VAL PHE GLN ASN GLU VAL LEU GLY          
SEQRES  44 A  721  THR LEU GLN ARG GLY LYS GLU GLU ASN ILE SER CYS ASP          
SEQRES  45 A  721  ASN LEU VAL LEU GLU ILE ASN SER LEU LYS TYR ALA TYR          
SEQRES  46 A  721  ASN VAL SER LEU LYS GLU VAL MET GLN VAL LEU SER HIS          
SEQRES  47 A  721  VAL VAL LEU GLU PHE PRO LEU GLN GLN MET ASP SER PRO          
SEQRES  48 A  721  LEU ASP SER SER ARG TYR CYS ALA LEU LEU LEU PRO LEU          
SEQRES  49 A  721  LEU LYS ALA TRP SER PRO VAL PHE ARG ASN TYR ILE LYS          
SEQRES  50 A  721  ARG ALA ALA ASP HIS LEU GLU ALA LEU ALA ALA ILE GLU          
SEQRES  51 A  721  ASP PHE PHE LEU GLU HIS GLU ALA LEU GLY ILE SER MET          
SEQRES  52 A  721  ALA LYS VAL LEU MET ALA PHE TYR GLN LEU GLU ILE LEU          
SEQRES  53 A  721  ALA GLU GLU THR ILE LEU SER TRP PHE SER GLN ARG ASP          
SEQRES  54 A  721  THR THR ASP LYS GLY GLN GLN LEU ARG LYS ASN GLN GLN          
SEQRES  55 A  721  LEU GLN ARG PHE ILE GLN TRP LEU LYS GLU ALA GLU GLU          
SEQRES  56 A  721  GLU SER SER GLU ASP ASP                                      
SEQRES   1 B  721  MET ALA ALA PRO VAL VAL ALA PRO PRO GLY VAL VAL VAL          
SEQRES   2 B  721  SER ARG ALA ASN LYS ARG SER GLY ALA GLY PRO GLY GLY          
SEQRES   3 B  721  SER GLY GLY GLY GLY ALA ARG GLY ALA GLU GLU GLU PRO          
SEQRES   4 B  721  PRO PRO PRO LEU GLN ALA VAL LEU VAL ALA ASP SER PHE          
SEQRES   5 B  721  ASP ARG ARG PHE PHE PRO ILE SER LYS ASP GLN PRO ARG          
SEQRES   6 B  721  VAL LEU LEU PRO LEU ALA ASN VAL ALA LEU ILE ASP TYR          
SEQRES   7 B  721  THR LEU GLU PHE LEU THR ALA THR GLY VAL GLN GLU THR          
SEQRES   8 B  721  PHE VAL PHE CYS CYS TRP LYS ALA ALA GLN ILE LYS GLU          
SEQRES   9 B  721  HIS LEU LEU LYS SER LYS TRP CYS ARG PRO THR SER LEU          
SEQRES  10 B  721  ASN VAL VAL ARG ILE ILE THR SER GLU LEU TYR ARG SER          
SEQRES  11 B  721  LEU GLY ASP VAL LEU ARG ASP VAL ASP ALA LYS ALA LEU          
SEQRES  12 B  721  VAL ARG SER ASP PHE LEU LEU VAL TYR GLY ASP VAL ILE          
SEQRES  13 B  721  SER ASN ILE ASN ILE THR ARG ALA LEU GLU GLU HIS ARG          
SEQRES  14 B  721  LEU ARG ARG LYS LEU GLU LYS ASN VAL SER VAL MET THR          
SEQRES  15 B  721  MET ILE PHE LYS GLU SER SER PRO SER HIS PRO THR ARG          
SEQRES  16 B  721  CYS HIS GLU ASP ASN VAL VAL VAL ALA VAL ASP SER THR          
SEQRES  17 B  721  THR ASN ARG VAL LEU HIS PHE GLN LYS THR GLN GLY LEU          
SEQRES  18 B  721  ARG ARG PHE ALA PHE PRO LEU SER LEU PHE GLN GLY SER          
SEQRES  19 B  721  SER ASP GLY VAL GLU VAL ARG TYR ASP LEU LEU ASP CYS          
SEQRES  20 B  721  HIS ILE SER ILE CYS SER PRO GLN VAL ALA GLN LEU PHE          
SEQRES  21 B  721  THR ASP ASN PHE ASP TYR GLN THR ARG ASP ASP PHE VAL          
SEQRES  22 B  721  ARG GLY LEU LEU VAL ASN GLU GLU ILE LEU GLY ASN GLN          
SEQRES  23 B  721  ILE HIS MET HIS VAL THR ALA LYS GLU TYR GLY ALA ARG          
SEQRES  24 B  721  VAL SER ASN LEU HIS MET TYR SER ALA VAL CYS ALA ASP          
SEQRES  25 B  721  VAL ILE ARG ARG TRP VAL TYR PRO LEU THR PRO GLU ALA          
SEQRES  26 B  721  ASN PHE THR ASP SER THR THR GLN SER CYS THR HIS SER          
SEQRES  27 B  721  ARG HIS ASN ILE TYR ARG GLY PRO GLU VAL SER LEU GLY          
SEQRES  28 B  721  HIS GLY SER ILE LEU GLU GLU ASN VAL LEU LEU GLY SER          
SEQRES  29 B  721  GLY THR VAL ILE GLY SER ASN CYS PHE ILE THR ASN SER          
SEQRES  30 B  721  VAL ILE GLY PRO GLY CYS HIS ILE GLY ASP ASN VAL VAL          
SEQRES  31 B  721  LEU ASP GLN THR TYR LEU TRP GLN GLY VAL ARG VAL ALA          
SEQRES  32 B  721  ALA GLY ALA GLN ILE HIS GLN SER LEU LEU CYS ASP ASN          
SEQRES  33 B  721  ALA GLU VAL LYS GLU ARG VAL THR LEU LYS PRO ARG SER          
SEQRES  34 B  721  VAL LEU THR SER GLN VAL VAL VAL GLY PRO ASN ILE THR          
SEQRES  35 B  721  LEU PRO GLU GLY SER VAL ILE SER LEU HIS PRO PRO ASP          
SEQRES  36 B  721  ALA GLU GLU ASP GLU ASP ASP GLY GLU PHE SER ASP ASP          
SEQRES  37 B  721  SER GLY ALA ASP GLN GLU LYS ASP LYS VAL LYS MET LYS          
SEQRES  38 B  721  GLY TYR ASN PRO ALA GLU VAL GLY ALA ALA GLY LYS GLY          
SEQRES  39 B  721  TYR LEU TRP LYS ALA ALA GLY MET ASN MET GLU GLU GLU          
SEQRES  40 B  721  GLU GLU LEU GLN GLN ASN LEU TRP GLY LEU LYS ILE ASN          
SEQRES  41 B  721  MET GLU GLU GLU SER GLU SER GLU SER GLU GLN SER MET          
SEQRES  42 B  721  ASP SER GLU GLU PRO ASP SER ARG GLY GLY SER PRO GLN          
SEQRES  43 B  721  MET ASP ASP ILE LYS VAL PHE GLN ASN GLU VAL LEU GLY          
SEQRES  44 B  721  THR LEU GLN ARG GLY LYS GLU GLU ASN ILE SER CYS ASP          
SEQRES  45 B  721  ASN LEU VAL LEU GLU ILE ASN SER LEU LYS TYR ALA TYR          
SEQRES  46 B  721  ASN VAL SER LEU LYS GLU VAL MET GLN VAL LEU SER HIS          
SEQRES  47 B  721  VAL VAL LEU GLU PHE PRO LEU GLN GLN MET ASP SER PRO          
SEQRES  48 B  721  LEU ASP SER SER ARG TYR CYS ALA LEU LEU LEU PRO LEU          
SEQRES  49 B  721  LEU LYS ALA TRP SER PRO VAL PHE ARG ASN TYR ILE LYS          
SEQRES  50 B  721  ARG ALA ALA ASP HIS LEU GLU ALA LEU ALA ALA ILE GLU          
SEQRES  51 B  721  ASP PHE PHE LEU GLU HIS GLU ALA LEU GLY ILE SER MET          
SEQRES  52 B  721  ALA LYS VAL LEU MET ALA PHE TYR GLN LEU GLU ILE LEU          
SEQRES  53 B  721  ALA GLU GLU THR ILE LEU SER TRP PHE SER GLN ARG ASP          
SEQRES  54 B  721  THR THR ASP LYS GLY GLN GLN LEU ARG LYS ASN GLN GLN          
SEQRES  55 B  721  LEU GLN ARG PHE ILE GLN TRP LEU LYS GLU ALA GLU GLU          
SEQRES  56 B  721  GLU SER SER GLU ASP ASP                                      
SEQRES   1 C  368  MET HIS HIS HIS HIS HIS HIS GLY GLY GLY SER GLU ASN          
SEQRES   2 C  368  LEU TYR PHE GLN SER PRO GLY SER ALA ALA LYS GLY SER          
SEQRES   3 C  368  GLU LEU SER GLU ARG ILE GLU SER PHE VAL GLU THR LEU          
SEQRES   4 C  368  LYS ARG GLY GLY GLY PRO ARG SER SER GLU GLU MET ALA          
SEQRES   5 C  368  ARG GLU THR LEU GLY LEU LEU ARG GLN ILE ILE THR ASP          
SEQRES   6 C  368  HIS ARG TRP SER ASN ALA GLY GLU LEU MET GLU LEU ILE          
SEQRES   7 C  368  ARG ARG GLU GLY ARG ARG MET THR ALA ALA GLN PRO SER          
SEQRES   8 C  368  GLU THR THR VAL GLY ASN MET VAL ARG ARG VAL LEU LYS          
SEQRES   9 C  368  ILE ILE ARG GLU GLU TYR GLY ARG LEU HIS GLY ARG SER          
SEQRES  10 C  368  ASP GLU SER ASP GLN GLN GLU SER LEU HIS LYS LEU LEU          
SEQRES  11 C  368  THR SER GLY GLY LEU ASN GLU ASP PHE SER PHE HIS TYR          
SEQRES  12 C  368  ALA GLN LEU GLN SER ASN ILE ILE GLU ALA ILE ASN GLU          
SEQRES  13 C  368  LEU LEU VAL GLU LEU GLU GLY THR MET GLU ASN ILE ALA          
SEQRES  14 C  368  ALA GLN ALA LEU GLU HIS ILE HIS SER ASN GLU VAL ILE          
SEQRES  15 C  368  MET THR ILE GLY PHE SER ARG THR VAL GLU ALA PHE LEU          
SEQRES  16 C  368  LYS GLU ALA ALA ARG LYS ARG LYS PHE HIS VAL ILE VAL          
SEQRES  17 C  368  ALA GLU CYS ALA PRO PHE CYS GLN GLY HIS GLU MET ALA          
SEQRES  18 C  368  VAL ASN LEU SER LYS ALA GLY ILE GLU THR THR VAL MET          
SEQRES  19 C  368  THR ASP ALA ALA ILE PHE ALA VAL MET SER ARG VAL ASN          
SEQRES  20 C  368  LYS VAL ILE ILE GLY THR LYS THR ILE LEU ALA ASN GLY          
SEQRES  21 C  368  ALA LEU ARG ALA VAL THR GLY THR HIS THR LEU ALA LEU          
SEQRES  22 C  368  ALA ALA LYS HIS HIS SER THR PRO LEU ILE VAL CYS ALA          
SEQRES  23 C  368  PRO MET PHE LYS LEU SER PRO GLN PHE PRO ASN GLU GLU          
SEQRES  24 C  368  ASP SER PHE HIS LYS PHE VAL ALA PRO GLU GLU VAL LEU          
SEQRES  25 C  368  PRO PHE THR GLU GLY ASP ILE LEU GLU LYS VAL SER VAL          
SEQRES  26 C  368  HIS CYS PRO VAL PHE ASP TYR VAL PRO PRO GLU LEU ILE          
SEQRES  27 C  368  THR LEU PHE ILE SER ASN ILE GLY GLY ASN ALA PRO SER          
SEQRES  28 C  368  TYR ILE TYR ARG LEU MET SER GLU LEU TYR HIS PRO ASP          
SEQRES  29 C  368  ASP HIS VAL LEU                                              
SEQRES   1 D  368  MET HIS HIS HIS HIS HIS HIS GLY GLY GLY SER GLU ASN          
SEQRES   2 D  368  LEU TYR PHE GLN SER PRO GLY SER ALA ALA LYS GLY SER          
SEQRES   3 D  368  GLU LEU SER GLU ARG ILE GLU SER PHE VAL GLU THR LEU          
SEQRES   4 D  368  LYS ARG GLY GLY GLY PRO ARG SER SER GLU GLU MET ALA          
SEQRES   5 D  368  ARG GLU THR LEU GLY LEU LEU ARG GLN ILE ILE THR ASP          
SEQRES   6 D  368  HIS ARG TRP SER ASN ALA GLY GLU LEU MET GLU LEU ILE          
SEQRES   7 D  368  ARG ARG GLU GLY ARG ARG MET THR ALA ALA GLN PRO SER          
SEQRES   8 D  368  GLU THR THR VAL GLY ASN MET VAL ARG ARG VAL LEU LYS          
SEQRES   9 D  368  ILE ILE ARG GLU GLU TYR GLY ARG LEU HIS GLY ARG SER          
SEQRES  10 D  368  ASP GLU SER ASP GLN GLN GLU SER LEU HIS LYS LEU LEU          
SEQRES  11 D  368  THR SER GLY GLY LEU ASN GLU ASP PHE SER PHE HIS TYR          
SEQRES  12 D  368  ALA GLN LEU GLN SER ASN ILE ILE GLU ALA ILE ASN GLU          
SEQRES  13 D  368  LEU LEU VAL GLU LEU GLU GLY THR MET GLU ASN ILE ALA          
SEQRES  14 D  368  ALA GLN ALA LEU GLU HIS ILE HIS SER ASN GLU VAL ILE          
SEQRES  15 D  368  MET THR ILE GLY PHE SER ARG THR VAL GLU ALA PHE LEU          
SEQRES  16 D  368  LYS GLU ALA ALA ARG LYS ARG LYS PHE HIS VAL ILE VAL          
SEQRES  17 D  368  ALA GLU CYS ALA PRO PHE CYS GLN GLY HIS GLU MET ALA          
SEQRES  18 D  368  VAL ASN LEU SER LYS ALA GLY ILE GLU THR THR VAL MET          
SEQRES  19 D  368  THR ASP ALA ALA ILE PHE ALA VAL MET SER ARG VAL ASN          
SEQRES  20 D  368  LYS VAL ILE ILE GLY THR LYS THR ILE LEU ALA ASN GLY          
SEQRES  21 D  368  ALA LEU ARG ALA VAL THR GLY THR HIS THR LEU ALA LEU          
SEQRES  22 D  368  ALA ALA LYS HIS HIS SER THR PRO LEU ILE VAL CYS ALA          
SEQRES  23 D  368  PRO MET PHE LYS LEU SER PRO GLN PHE PRO ASN GLU GLU          
SEQRES  24 D  368  ASP SER PHE HIS LYS PHE VAL ALA PRO GLU GLU VAL LEU          
SEQRES  25 D  368  PRO PHE THR GLU GLY ASP ILE LEU GLU LYS VAL SER VAL          
SEQRES  26 D  368  HIS CYS PRO VAL PHE ASP TYR VAL PRO PRO GLU LEU ILE          
SEQRES  27 D  368  THR LEU PHE ILE SER ASN ILE GLY GLY ASN ALA PRO SER          
SEQRES  28 D  368  TYR ILE TYR ARG LEU MET SER GLU LEU TYR HIS PRO ASP          
SEQRES  29 D  368  ASP HIS VAL LEU                                              
SEQRES   1 E  523  MET ALA ALA VAL ALA VAL ALA VAL ARG GLU ASP SER GLY          
SEQRES   2 E  523  SER GLY MET LYS ALA GLU LEU PRO PRO GLY PRO GLY ALA          
SEQRES   3 E  523  VAL GLY ARG GLU MET THR LYS GLU GLU LYS LEU GLN LEU          
SEQRES   4 E  523  ARG LYS GLU LYS LYS GLN GLN LYS LYS LYS ARG LYS GLU          
SEQRES   5 E  523  GLU LYS GLY ALA GLU PRO GLU THR GLY SER ALA VAL SER          
SEQRES   6 E  523  ALA ALA GLN CYS GLN VAL GLY PRO THR ARG GLU LEU PRO          
SEQRES   7 E  523  GLU SER GLY ILE GLN LEU GLY THR PRO ARG GLU LYS VAL          
SEQRES   8 E  523  PRO ALA GLY ARG SER LYS ALA GLU LEU ARG ALA GLU ARG          
SEQRES   9 E  523  ARG ALA LYS GLN GLU ALA GLU ARG ALA LEU LYS GLN ALA          
SEQRES  10 E  523  ARG LYS GLY GLU GLN GLY GLY PRO PRO PRO LYS ALA SER          
SEQRES  11 E  523  PRO SER THR ALA GLY GLU THR PRO SER GLY VAL LYS ARG          
SEQRES  12 E  523  LEU PRO GLU TYR PRO GLN VAL ASP ASP LEU LEU LEU ARG          
SEQRES  13 E  523  ARG LEU VAL LYS LYS PRO GLU ARG GLN GLN VAL PRO THR          
SEQRES  14 E  523  ARG LYS ASP TYR GLY SER LYS VAL SER LEU PHE SER HIS          
SEQRES  15 E  523  LEU PRO GLN TYR SER ARG GLN ASN SER LEU THR GLN PHE          
SEQRES  16 E  523  MET SER ILE PRO SER SER VAL ILE HIS PRO ALA MET VAL          
SEQRES  17 E  523  ARG LEU GLY LEU GLN TYR SER GLN GLY LEU VAL SER GLY          
SEQRES  18 E  523  SER ASN ALA ARG CYS ILE ALA LEU LEU ARG ALA LEU GLN          
SEQRES  19 E  523  GLN VAL ILE GLN ASP TYR THR THR PRO PRO ASN GLU GLU          
SEQRES  20 E  523  LEU SER ARG ASP LEU VAL ASN LYS LEU LYS PRO TYR MET          
SEQRES  21 E  523  SER PHE LEU THR GLN CYS ARG PRO LEU SER ALA SER MET          
SEQRES  22 E  523  HIS ASN ALA ILE LYS PHE LEU ASN LYS GLU ILE THR SER          
SEQRES  23 E  523  VAL GLY SER SER LYS ARG GLU GLU GLU ALA LYS SER GLU          
SEQRES  24 E  523  LEU ARG ALA ALA ILE ASP ARG TYR VAL GLN GLU LYS ILE          
SEQRES  25 E  523  VAL LEU ALA ALA GLN ALA ILE SER ARG PHE ALA TYR GLN          
SEQRES  26 E  523  LYS ILE SER ASN GLY ASP VAL ILE LEU VAL TYR GLY CYS          
SEQRES  27 E  523  SER SER LEU VAL SER ARG ILE LEU GLN GLU ALA TRP THR          
SEQRES  28 E  523  GLU GLY ARG ARG PHE ARG VAL VAL VAL VAL ASP SER ARG          
SEQRES  29 E  523  PRO TRP LEU GLU GLY ARG HIS THR LEU ARG SER LEU VAL          
SEQRES  30 E  523  HIS ALA GLY VAL PRO ALA SER TYR LEU LEU ILE PRO ALA          
SEQRES  31 E  523  ALA SER TYR VAL LEU PRO GLU VAL SER LYS VAL LEU LEU          
SEQRES  32 E  523  GLY ALA HIS ALA LEU LEU ALA ASN GLY SER VAL MET SER          
SEQRES  33 E  523  ARG VAL GLY THR ALA GLN LEU ALA LEU VAL ALA ARG ALA          
SEQRES  34 E  523  HIS ASN VAL PRO VAL LEU VAL CYS CYS GLU THR TYR LYS          
SEQRES  35 E  523  PHE CYS GLU ARG VAL GLN THR ASP ALA PHE VAL SER ASN          
SEQRES  36 E  523  GLU LEU ASP ASP PRO ASP ASP LEU GLN CYS LYS ARG GLY          
SEQRES  37 E  523  GLU HIS VAL ALA LEU ALA ASN TRP GLN ASN HIS ALA SER          
SEQRES  38 E  523  LEU ARG LEU LEU ASN LEU VAL TYR ASP VAL THR PRO PRO          
SEQRES  39 E  523  GLU LEU VAL ASP LEU VAL ILE THR GLU LEU GLY MET ILE          
SEQRES  40 E  523  PRO CYS SER SER VAL PRO VAL VAL LEU ARG VAL LYS SER          
SEQRES  41 E  523  SER ASP GLN                                                  
SEQRES   1 F  523  MET ALA ALA VAL ALA VAL ALA VAL ARG GLU ASP SER GLY          
SEQRES   2 F  523  SER GLY MET LYS ALA GLU LEU PRO PRO GLY PRO GLY ALA          
SEQRES   3 F  523  VAL GLY ARG GLU MET THR LYS GLU GLU LYS LEU GLN LEU          
SEQRES   4 F  523  ARG LYS GLU LYS LYS GLN GLN LYS LYS LYS ARG LYS GLU          
SEQRES   5 F  523  GLU LYS GLY ALA GLU PRO GLU THR GLY SER ALA VAL SER          
SEQRES   6 F  523  ALA ALA GLN CYS GLN VAL GLY PRO THR ARG GLU LEU PRO          
SEQRES   7 F  523  GLU SER GLY ILE GLN LEU GLY THR PRO ARG GLU LYS VAL          
SEQRES   8 F  523  PRO ALA GLY ARG SER LYS ALA GLU LEU ARG ALA GLU ARG          
SEQRES   9 F  523  ARG ALA LYS GLN GLU ALA GLU ARG ALA LEU LYS GLN ALA          
SEQRES  10 F  523  ARG LYS GLY GLU GLN GLY GLY PRO PRO PRO LYS ALA SER          
SEQRES  11 F  523  PRO SER THR ALA GLY GLU THR PRO SER GLY VAL LYS ARG          
SEQRES  12 F  523  LEU PRO GLU TYR PRO GLN VAL ASP ASP LEU LEU LEU ARG          
SEQRES  13 F  523  ARG LEU VAL LYS LYS PRO GLU ARG GLN GLN VAL PRO THR          
SEQRES  14 F  523  ARG LYS ASP TYR GLY SER LYS VAL SER LEU PHE SER HIS          
SEQRES  15 F  523  LEU PRO GLN TYR SER ARG GLN ASN SER LEU THR GLN PHE          
SEQRES  16 F  523  MET SER ILE PRO SER SER VAL ILE HIS PRO ALA MET VAL          
SEQRES  17 F  523  ARG LEU GLY LEU GLN TYR SER GLN GLY LEU VAL SER GLY          
SEQRES  18 F  523  SER ASN ALA ARG CYS ILE ALA LEU LEU ARG ALA LEU GLN          
SEQRES  19 F  523  GLN VAL ILE GLN ASP TYR THR THR PRO PRO ASN GLU GLU          
SEQRES  20 F  523  LEU SER ARG ASP LEU VAL ASN LYS LEU LYS PRO TYR MET          
SEQRES  21 F  523  SER PHE LEU THR GLN CYS ARG PRO LEU SER ALA SER MET          
SEQRES  22 F  523  HIS ASN ALA ILE LYS PHE LEU ASN LYS GLU ILE THR SER          
SEQRES  23 F  523  VAL GLY SER SER LYS ARG GLU GLU GLU ALA LYS SER GLU          
SEQRES  24 F  523  LEU ARG ALA ALA ILE ASP ARG TYR VAL GLN GLU LYS ILE          
SEQRES  25 F  523  VAL LEU ALA ALA GLN ALA ILE SER ARG PHE ALA TYR GLN          
SEQRES  26 F  523  LYS ILE SER ASN GLY ASP VAL ILE LEU VAL TYR GLY CYS          
SEQRES  27 F  523  SER SER LEU VAL SER ARG ILE LEU GLN GLU ALA TRP THR          
SEQRES  28 F  523  GLU GLY ARG ARG PHE ARG VAL VAL VAL VAL ASP SER ARG          
SEQRES  29 F  523  PRO TRP LEU GLU GLY ARG HIS THR LEU ARG SER LEU VAL          
SEQRES  30 F  523  HIS ALA GLY VAL PRO ALA SER TYR LEU LEU ILE PRO ALA          
SEQRES  31 F  523  ALA SER TYR VAL LEU PRO GLU VAL SER LYS VAL LEU LEU          
SEQRES  32 F  523  GLY ALA HIS ALA LEU LEU ALA ASN GLY SER VAL MET SER          
SEQRES  33 F  523  ARG VAL GLY THR ALA GLN LEU ALA LEU VAL ALA ARG ALA          
SEQRES  34 F  523  HIS ASN VAL PRO VAL LEU VAL CYS CYS GLU THR TYR LYS          
SEQRES  35 F  523  PHE CYS GLU ARG VAL GLN THR ASP ALA PHE VAL SER ASN          
SEQRES  36 F  523  GLU LEU ASP ASP PRO ASP ASP LEU GLN CYS LYS ARG GLY          
SEQRES  37 F  523  GLU HIS VAL ALA LEU ALA ASN TRP GLN ASN HIS ALA SER          
SEQRES  38 F  523  LEU ARG LEU LEU ASN LEU VAL TYR ASP VAL THR PRO PRO          
SEQRES  39 F  523  GLU LEU VAL ASP LEU VAL ILE THR GLU LEU GLY MET ILE          
SEQRES  40 F  523  PRO CYS SER SER VAL PRO VAL VAL LEU ARG VAL LYS SER          
SEQRES  41 F  523  SER ASP GLN                                                  
SEQRES   1 G  305  MET ASP ASP LYS GLU LEU ILE GLU TYR PHE LYS SER GLN          
SEQRES   2 G  305  MET LYS GLU ASP PRO ASP MET ALA SER ALA VAL ALA ALA          
SEQRES   3 G  305  ILE ARG THR LEU LEU GLU PHE LEU LYS ARG ASP LYS GLY          
SEQRES   4 G  305  GLU THR ILE GLN GLY LEU ARG ALA ASN LEU THR SER ALA          
SEQRES   5 G  305  ILE GLU THR LEU CYS GLY VAL ASP SER SER VAL ALA VAL          
SEQRES   6 G  305  SER SER GLY GLY GLU LEU PHE LEU ARG PHE ILE SER LEU          
SEQRES   7 G  305  ALA SER LEU GLU TYR SER ASP TYR SER LYS CYS LYS LYS          
SEQRES   8 G  305  ILE MET ILE GLU ARG GLY GLU LEU PHE LEU ARG ARG ILE          
SEQRES   9 G  305  SER LEU SER ARG ASN LYS ILE ALA ASP LEU CYS HIS THR          
SEQRES  10 G  305  PHE ILE LYS ASP GLY ALA THR ILE LEU THR HIS ALA TYR          
SEQRES  11 G  305  SER ARG VAL VAL LEU ARG VAL LEU GLU ALA ALA VAL ALA          
SEQRES  12 G  305  ALA LYS LYS ARG PHE SER VAL TYR VAL THR GLU SER GLN          
SEQRES  13 G  305  PRO ASP LEU SER GLY LYS LYS MET ALA LYS ALA LEU CYS          
SEQRES  14 G  305  HIS LEU ASN VAL PRO VAL THR VAL VAL LEU ASP ALA ALA          
SEQRES  15 G  305  VAL GLY TYR ILE MET GLU LYS ALA ASP LEU VAL ILE VAL          
SEQRES  16 G  305  GLY ALA GLU GLY VAL VAL GLU ASN GLY GLY ILE ILE ASN          
SEQRES  17 G  305  LYS ILE GLY THR ASN GLN MET ALA VAL CYS ALA LYS ALA          
SEQRES  18 G  305  GLN ASN LYS PRO PHE TYR VAL VAL ALA GLU SER PHE LYS          
SEQRES  19 G  305  PHE VAL ARG LEU PHE PRO LEU ASN GLN GLN ASP VAL PRO          
SEQRES  20 G  305  ASP LYS PHE LYS TYR LYS ALA ASP THR LEU LYS VAL ALA          
SEQRES  21 G  305  GLN THR GLY GLN ASP LEU LYS GLU GLU HIS PRO TRP VAL          
SEQRES  22 G  305  ASP TYR THR ALA PRO SER LEU ILE THR LEU LEU PHE THR          
SEQRES  23 G  305  ASP LEU GLY VAL LEU THR PRO SER ALA VAL SER ASP GLU          
SEQRES  24 G  305  LEU ILE LYS LEU TYR LEU                                      
SEQRES   1 H  305  MET ASP ASP LYS GLU LEU ILE GLU TYR PHE LYS SER GLN          
SEQRES   2 H  305  MET LYS GLU ASP PRO ASP MET ALA SER ALA VAL ALA ALA          
SEQRES   3 H  305  ILE ARG THR LEU LEU GLU PHE LEU LYS ARG ASP LYS GLY          
SEQRES   4 H  305  GLU THR ILE GLN GLY LEU ARG ALA ASN LEU THR SER ALA          
SEQRES   5 H  305  ILE GLU THR LEU CYS GLY VAL ASP SER SER VAL ALA VAL          
SEQRES   6 H  305  SER SER GLY GLY GLU LEU PHE LEU ARG PHE ILE SER LEU          
SEQRES   7 H  305  ALA SER LEU GLU TYR SER ASP TYR SER LYS CYS LYS LYS          
SEQRES   8 H  305  ILE MET ILE GLU ARG GLY GLU LEU PHE LEU ARG ARG ILE          
SEQRES   9 H  305  SER LEU SER ARG ASN LYS ILE ALA ASP LEU CYS HIS THR          
SEQRES  10 H  305  PHE ILE LYS ASP GLY ALA THR ILE LEU THR HIS ALA TYR          
SEQRES  11 H  305  SER ARG VAL VAL LEU ARG VAL LEU GLU ALA ALA VAL ALA          
SEQRES  12 H  305  ALA LYS LYS ARG PHE SER VAL TYR VAL THR GLU SER GLN          
SEQRES  13 H  305  PRO ASP LEU SER GLY LYS LYS MET ALA LYS ALA LEU CYS          
SEQRES  14 H  305  HIS LEU ASN VAL PRO VAL THR VAL VAL LEU ASP ALA ALA          
SEQRES  15 H  305  VAL GLY TYR ILE MET GLU LYS ALA ASP LEU VAL ILE VAL          
SEQRES  16 H  305  GLY ALA GLU GLY VAL VAL GLU ASN GLY GLY ILE ILE ASN          
SEQRES  17 H  305  LYS ILE GLY THR ASN GLN MET ALA VAL CYS ALA LYS ALA          
SEQRES  18 H  305  GLN ASN LYS PRO PHE TYR VAL VAL ALA GLU SER PHE LYS          
SEQRES  19 H  305  PHE VAL ARG LEU PHE PRO LEU ASN GLN GLN ASP VAL PRO          
SEQRES  20 H  305  ASP LYS PHE LYS TYR LYS ALA ASP THR LEU LYS VAL ALA          
SEQRES  21 H  305  GLN THR GLY GLN ASP LEU LYS GLU GLU HIS PRO TRP VAL          
SEQRES  22 H  305  ASP TYR THR ALA PRO SER LEU ILE THR LEU LEU PHE THR          
SEQRES  23 H  305  ASP LEU GLY VAL LEU THR PRO SER ALA VAL SER ASP GLU          
SEQRES  24 H  305  LEU ILE LYS LEU TYR LEU                                      
SEQRES   1 I  452  MET GLU PHE GLN ALA VAL VAL MET ALA VAL GLY GLY GLY          
SEQRES   2 I  452  SER ARG MET THR ASP LEU THR SER SER ILE PRO LYS PRO          
SEQRES   3 I  452  LEU LEU PRO VAL GLY ASN LYS PRO LEU ILE TRP TYR PRO          
SEQRES   4 I  452  LEU ASN LEU LEU GLU ARG VAL GLY PHE GLU GLU VAL ILE          
SEQRES   5 I  452  VAL VAL THR THR ARG ASP VAL GLN LYS ALA LEU CYS ALA          
SEQRES   6 I  452  GLU PHE LYS MET LYS MET LYS PRO ASP ILE VAL CYS ILE          
SEQRES   7 I  452  PRO ASP ASP ALA ASP MET GLY THR ALA ASP SER LEU ARG          
SEQRES   8 I  452  TYR ILE TYR PRO LYS LEU LYS THR ASP VAL LEU VAL LEU          
SEQRES   9 I  452  SER CYS ASP LEU ILE THR ASP VAL ALA LEU HIS GLU VAL          
SEQRES  10 I  452  VAL ASP LEU PHE ARG ALA TYR ASP ALA SER LEU ALA MET          
SEQRES  11 I  452  LEU MET ARG LYS GLY GLN ASP SER ILE GLU PRO VAL PRO          
SEQRES  12 I  452  GLY GLN LYS GLY LYS LYS LYS ALA VAL GLU GLN ARG ASP          
SEQRES  13 I  452  PHE ILE GLY VAL ASP SER THR GLY LYS ARG LEU LEU PHE          
SEQRES  14 I  452  MET ALA ASN GLU ALA ASP LEU ASP GLU GLU LEU VAL ILE          
SEQRES  15 I  452  LYS GLY SER ILE LEU GLN LYS HIS PRO ARG ILE ARG PHE          
SEQRES  16 I  452  HIS THR GLY LEU VAL ASP ALA HIS LEU TYR CYS LEU LYS          
SEQRES  17 I  452  LYS TYR ILE VAL ASP PHE LEU MET GLU ASN GLY SER ILE          
SEQRES  18 I  452  THR SER ILE ARG SER GLU LEU ILE PRO TYR LEU VAL ARG          
SEQRES  19 I  452  LYS GLN PHE SER SER ALA SER SER GLN GLN GLY GLN GLU          
SEQRES  20 I  452  GLU LYS GLU GLU ASP LEU LYS LYS LYS GLU LEU LYS SER          
SEQRES  21 I  452  LEU ASP ILE TYR SER PHE ILE LYS GLU ALA ASN THR LEU          
SEQRES  22 I  452  ASN LEU ALA PRO TYR ASP ALA CYS TRP ASN ALA CYS ARG          
SEQRES  23 I  452  GLY ASP ARG TRP GLU ASP LEU SER ARG SER GLN VAL ARG          
SEQRES  24 I  452  CYS TYR VAL HIS ILE MET LYS GLU GLY LEU CYS SER ARG          
SEQRES  25 I  452  VAL SER THR LEU GLY LEU TYR MET GLU ALA ASN ARG GLN          
SEQRES  26 I  452  VAL PRO LYS LEU LEU SER ALA LEU CYS PRO GLU GLU PRO          
SEQRES  27 I  452  PRO VAL HIS SER SER ALA GLN ILE VAL SER LYS HIS LEU          
SEQRES  28 I  452  VAL GLY VAL ASP SER LEU ILE GLY PRO GLU THR GLN ILE          
SEQRES  29 I  452  GLY GLU LYS SER SER ILE LYS ARG SER VAL ILE GLY SER          
SEQRES  30 I  452  SER CYS LEU ILE LYS ASP ARG VAL THR ILE THR ASN CYS          
SEQRES  31 I  452  LEU LEU MET ASN SER VAL THR VAL GLU GLU GLY SER ASN          
SEQRES  32 I  452  ILE GLN GLY SER VAL ILE CYS ASN ASN ALA VAL ILE GLU          
SEQRES  33 I  452  LYS GLY ALA ASP ILE LYS ASP CYS LEU ILE GLY SER GLY          
SEQRES  34 I  452  GLN ARG ILE GLU ALA LYS ALA LYS ARG VAL ASN GLU VAL          
SEQRES  35 I  452  ILE VAL GLY ASN ASP GLN LEU MET GLU ILE                      
SEQRES   1 J  452  MET GLU PHE GLN ALA VAL VAL MET ALA VAL GLY GLY GLY          
SEQRES   2 J  452  SER ARG MET THR ASP LEU THR SER SER ILE PRO LYS PRO          
SEQRES   3 J  452  LEU LEU PRO VAL GLY ASN LYS PRO LEU ILE TRP TYR PRO          
SEQRES   4 J  452  LEU ASN LEU LEU GLU ARG VAL GLY PHE GLU GLU VAL ILE          
SEQRES   5 J  452  VAL VAL THR THR ARG ASP VAL GLN LYS ALA LEU CYS ALA          
SEQRES   6 J  452  GLU PHE LYS MET LYS MET LYS PRO ASP ILE VAL CYS ILE          
SEQRES   7 J  452  PRO ASP ASP ALA ASP MET GLY THR ALA ASP SER LEU ARG          
SEQRES   8 J  452  TYR ILE TYR PRO LYS LEU LYS THR ASP VAL LEU VAL LEU          
SEQRES   9 J  452  SER CYS ASP LEU ILE THR ASP VAL ALA LEU HIS GLU VAL          
SEQRES  10 J  452  VAL ASP LEU PHE ARG ALA TYR ASP ALA SER LEU ALA MET          
SEQRES  11 J  452  LEU MET ARG LYS GLY GLN ASP SER ILE GLU PRO VAL PRO          
SEQRES  12 J  452  GLY GLN LYS GLY LYS LYS LYS ALA VAL GLU GLN ARG ASP          
SEQRES  13 J  452  PHE ILE GLY VAL ASP SER THR GLY LYS ARG LEU LEU PHE          
SEQRES  14 J  452  MET ALA ASN GLU ALA ASP LEU ASP GLU GLU LEU VAL ILE          
SEQRES  15 J  452  LYS GLY SER ILE LEU GLN LYS HIS PRO ARG ILE ARG PHE          
SEQRES  16 J  452  HIS THR GLY LEU VAL ASP ALA HIS LEU TYR CYS LEU LYS          
SEQRES  17 J  452  LYS TYR ILE VAL ASP PHE LEU MET GLU ASN GLY SER ILE          
SEQRES  18 J  452  THR SER ILE ARG SER GLU LEU ILE PRO TYR LEU VAL ARG          
SEQRES  19 J  452  LYS GLN PHE SER SER ALA SER SER GLN GLN GLY GLN GLU          
SEQRES  20 J  452  GLU LYS GLU GLU ASP LEU LYS LYS LYS GLU LEU LYS SER          
SEQRES  21 J  452  LEU ASP ILE TYR SER PHE ILE LYS GLU ALA ASN THR LEU          
SEQRES  22 J  452  ASN LEU ALA PRO TYR ASP ALA CYS TRP ASN ALA CYS ARG          
SEQRES  23 J  452  GLY ASP ARG TRP GLU ASP LEU SER ARG SER GLN VAL ARG          
SEQRES  24 J  452  CYS TYR VAL HIS ILE MET LYS GLU GLY LEU CYS SER ARG          
SEQRES  25 J  452  VAL SER THR LEU GLY LEU TYR MET GLU ALA ASN ARG GLN          
SEQRES  26 J  452  VAL PRO LYS LEU LEU SER ALA LEU CYS PRO GLU GLU PRO          
SEQRES  27 J  452  PRO VAL HIS SER SER ALA GLN ILE VAL SER LYS HIS LEU          
SEQRES  28 J  452  VAL GLY VAL ASP SER LEU ILE GLY PRO GLU THR GLN ILE          
SEQRES  29 J  452  GLY GLU LYS SER SER ILE LYS ARG SER VAL ILE GLY SER          
SEQRES  30 J  452  SER CYS LEU ILE LYS ASP ARG VAL THR ILE THR ASN CYS          
SEQRES  31 J  452  LEU LEU MET ASN SER VAL THR VAL GLU GLU GLY SER ASN          
SEQRES  32 J  452  ILE GLN GLY SER VAL ILE CYS ASN ASN ALA VAL ILE GLU          
SEQRES  33 J  452  LYS GLY ALA ASP ILE LYS ASP CYS LEU ILE GLY SER GLY          
SEQRES  34 J  452  GLN ARG ILE GLU ALA LYS ALA LYS ARG VAL ASN GLU VAL          
SEQRES  35 J  452  ILE VAL GLY ASN ASP GLN LEU MET GLU ILE                      
SEQRES   1 L  323  MET ASP TYR LYS ASP ASP ASP ASP LYS PRO GLY LEU SER          
SEQRES   2 L  323  CYS ARG PHE TYR GLN HIS LYS PHE PRO GLU VAL GLU ASP          
SEQRES   3 L  323  VAL VAL MET VAL ASN VAL ARG SER ILE ALA GLU MET GLY          
SEQRES   4 L  323  ALA TYR VAL SER LEU LEU GLU TYR ASN ASN ILE GLU GLY          
SEQRES   5 L  323  MET ILE LEU LEU SER GLU LEU SEP ARG ARG ARG ILE ARG          
SEQRES   6 L  323  SER ILE ASN LYS LEU ILE ARG ILE GLY ARG ASN GLU CYS          
SEQRES   7 L  323  VAL VAL VAL ILE ARG VAL ASP LYS GLU LYS GLY TYR ILE          
SEQRES   8 L  323  ASP LEU SER LYS ARG ARG VAL SER PRO GLU GLU ALA ILE          
SEQRES   9 L  323  LYS CYS GLU ASP LYS PHE THR LYS SER LYS THR VAL TYR          
SEQRES  10 L  323  SER ILE LEU ARG HIS VAL ALA GLU VAL LEU GLU TYR THR          
SEQRES  11 L  323  LYS ASP GLU GLN LEU GLU SER LEU PHE GLN ARG THR ALA          
SEQRES  12 L  323  TRP VAL PHE ASP ASP LYS TYR LYS ARG PRO GLY TYR GLY          
SEQRES  13 L  323  ALA TYR ASP ALA PHE LYS HIS ALA VAL SER ASP PRO SER          
SEQRES  14 L  323  ILE LEU ASP SER LEU ASP LEU ASN GLU ASP GLU ARG GLU          
SEQRES  15 L  323  VAL LEU ILE ASN ASN ILE ASN ARG ARG LEU THR PRO GLN          
SEQRES  16 L  323  ALA VAL LYS ILE ARG ALA ASP ILE GLU VAL ALA CYS TYR          
SEQRES  17 L  323  GLY TYR GLU GLY ILE ASP ALA VAL LYS GLU ALA LEU ARG          
SEQRES  18 L  323  ALA GLY LEU ASN CYS SER THR GLU ASN MET PRO ILE LYS          
SEQRES  19 L  323  ILE ASN LEU ILE ALA PRO PRO ARG TYR VAL MET THR THR          
SEQRES  20 L  323  THR THR LEU GLU ARG THR GLU GLY LEU SER VAL LEU SER          
SEQRES  21 L  323  GLN ALA MET ALA VAL ILE LYS GLU LYS ILE GLU GLU LYS          
SEQRES  22 L  323  ARG GLY VAL PHE ASN VAL GLN MET GLU PRO LYS VAL VAL          
SEQRES  23 L  323  THR ASP THR ASP GLU THR GLU LEU ALA ARG GLN MET GLU          
SEQRES  24 L  323  ARG LEU GLU ARG GLU ASN ALA GLU VAL ASP GLY ASP ASP          
SEQRES  25 L  323  ASP ALA GLU GLU MET GLU ALA LYS ALA GLU ASP                  
SEQRES   1 M  323  MET ASP TYR LYS ASP ASP ASP ASP LYS PRO GLY LEU SER          
SEQRES   2 M  323  CYS ARG PHE TYR GLN HIS LYS PHE PRO GLU VAL GLU ASP          
SEQRES   3 M  323  VAL VAL MET VAL ASN VAL ARG SER ILE ALA GLU MET GLY          
SEQRES   4 M  323  ALA TYR VAL SER LEU LEU GLU TYR ASN ASN ILE GLU GLY          
SEQRES   5 M  323  MET ILE LEU LEU SER GLU LEU SEP ARG ARG ARG ILE ARG          
SEQRES   6 M  323  SER ILE ASN LYS LEU ILE ARG ILE GLY ARG ASN GLU CYS          
SEQRES   7 M  323  VAL VAL VAL ILE ARG VAL ASP LYS GLU LYS GLY TYR ILE          
SEQRES   8 M  323  ASP LEU SER LYS ARG ARG VAL SER PRO GLU GLU ALA ILE          
SEQRES   9 M  323  LYS CYS GLU ASP LYS PHE THR LYS SER LYS THR VAL TYR          
SEQRES  10 M  323  SER ILE LEU ARG HIS VAL ALA GLU VAL LEU GLU TYR THR          
SEQRES  11 M  323  LYS ASP GLU GLN LEU GLU SER LEU PHE GLN ARG THR ALA          
SEQRES  12 M  323  TRP VAL PHE ASP ASP LYS TYR LYS ARG PRO GLY TYR GLY          
SEQRES  13 M  323  ALA TYR ASP ALA PHE LYS HIS ALA VAL SER ASP PRO SER          
SEQRES  14 M  323  ILE LEU ASP SER LEU ASP LEU ASN GLU ASP GLU ARG GLU          
SEQRES  15 M  323  VAL LEU ILE ASN ASN ILE ASN ARG ARG LEU THR PRO GLN          
SEQRES  16 M  323  ALA VAL LYS ILE ARG ALA ASP ILE GLU VAL ALA CYS TYR          
SEQRES  17 M  323  GLY TYR GLU GLY ILE ASP ALA VAL LYS GLU ALA LEU ARG          
SEQRES  18 M  323  ALA GLY LEU ASN CYS SER THR GLU ASN MET PRO ILE LYS          
SEQRES  19 M  323  ILE ASN LEU ILE ALA PRO PRO ARG TYR VAL MET THR THR          
SEQRES  20 M  323  THR THR LEU GLU ARG THR GLU GLY LEU SER VAL LEU SER          
SEQRES  21 M  323  GLN ALA MET ALA VAL ILE LYS GLU LYS ILE GLU GLU LYS          
SEQRES  22 M  323  ARG GLY VAL PHE ASN VAL GLN MET GLU PRO LYS VAL VAL          
SEQRES  23 M  323  THR ASP THR ASP GLU THR GLU LEU ALA ARG GLN MET GLU          
SEQRES  24 M  323  ARG LEU GLU ARG GLU ASN ALA GLU VAL ASP GLY ASP ASP          
SEQRES  25 M  323  ASP ALA GLU GLU MET GLU ALA LYS ALA GLU ASP                  
MODRES 6O9Z SEP L   51  SER  MODIFIED RESIDUE                                   
MODRES 6O9Z SEP M   51  SER  MODIFIED RESIDUE                                   
HET    SEP  L  51      10                                                       
HET    SEP  M  51      10                                                       
HETNAM     SEP PHOSPHOSERINE                                                    
HETSYN     SEP PHOSPHONOSERINE                                                  
FORMUL  11  SEP    2(C3 H8 N O6 P)                                              
HELIX    1 AA1 PRO A   64  LEU A   68  5                                   5    
HELIX    2 AA2 ALA A   74  GLY A   87  1                                  14    
HELIX    3 AA3 LYS A   98  LYS A  108  1                                  11    
HELIX    4 AA4 SER A  130  ALA A  142  1                                  13    
HELIX    5 AA5 ILE A  161  GLU A  175  1                                  15    
HELIX    6 AA6 LEU A  228  SER A  234  1                                   7    
HELIX    7 AA7 SER A  253  ASN A  263  1                                  11    
HELIX    8 AA8 THR A  268  VAL A  278  1                                  11    
HELIX    9 AA9 ASN A  302  ARG A  315  1                                  14    
HELIX   10 AB1 ARG A  339  ASN A  341  5                                   3    
HELIX   11 AB2 PRO B   64  LEU B   68  5                                   5    
HELIX   12 AB3 ALA B   74  GLY B   87  1                                  14    
HELIX   13 AB4 LYS B   98  LYS B  108  1                                  11    
HELIX   14 AB5 SER B  130  ALA B  142  1                                  13    
HELIX   15 AB6 ILE B  161  GLU B  175  1                                  15    
HELIX   16 AB7 LEU B  228  SER B  234  1                                   7    
HELIX   17 AB8 SER B  253  ASN B  263  1                                  11    
HELIX   18 AB9 THR B  268  VAL B  278  1                                  11    
HELIX   19 AC1 ASN B  302  ARG B  315  1                                  14    
HELIX   20 AC2 ARG B  339  ASN B  341  5                                   3    
HELIX   21 AC3 SER C    9  GLY C   25  1                                  17    
HELIX   22 AC4 SER C   30  THR C   47  1                                  18    
HELIX   23 AC5 ASN C   53  GLN C   72  1                                  20    
HELIX   24 AC6 THR C   76  GLY C   98  1                                  23    
HELIX   25 AC7 GLN C  128  GLY C  146  1                                  19    
HELIX   26 AC8 GLY C  146  GLN C  154  1                                   9    
HELIX   27 AC9 ALA C  155  HIS C  158  5                                   4    
HELIX   28 AD1 SER C  171  ALA C  182  1                                  12    
HELIX   29 AD2 GLN C  199  SER C  208  1                                  10    
HELIX   30 AD3 ALA C  221  MET C  226  1                                   6    
HELIX   31 AD4 GLY C  250  HIS C  261  1                                  12    
HELIX   32 AD5 PRO C  296  GLU C  304  5                                   9    
HELIX   33 AD6 PRO C  317  ILE C  321  5                                   5    
HELIX   34 AD7 ALA C  332  SER C  334  5                                   3    
HELIX   35 AD8 TYR C  335  TYR C  344  1                                  10    
HELIX   36 AD9 HIS C  345  HIS C  349  5                                   5    
HELIX   37 AE1 SER D    9  GLY D   25  1                                  17    
HELIX   38 AE2 SER D   30  ASP D   48  1                                  19    
HELIX   39 AE3 ASN D   53  GLN D   72  1                                  20    
HELIX   40 AE4 THR D   76  GLY D   98  1                                  23    
HELIX   41 AE5 TYR D  126  GLU D  145  1                                  20    
HELIX   42 AE6 GLY D  146  GLN D  154  1                                   9    
HELIX   43 AE7 ALA D  155  HIS D  158  5                                   4    
HELIX   44 AE8 SER D  171  ALA D  182  1                                  12    
HELIX   45 AE9 GLN D  199  SER D  208  1                                  10    
HELIX   46 AF1 ALA D  221  MET D  226  1                                   6    
HELIX   47 AF2 GLY D  250  HIS D  261  1                                  12    
HELIX   48 AF3 PRO D  296  GLU D  304  5                                   9    
HELIX   49 AF4 PRO D  317  ILE D  321  5                                   5    
HELIX   50 AF5 TYR D  335  TYR D  344  1                                  10    
HELIX   51 AF6 SER E  191  MET E  196  5                                   6    
HELIX   52 AF7 HIS E  204  GLN E  216  1                                  13    
HELIX   53 AF8 GLY E  221  ASP E  239  1                                  19    
HELIX   54 AF9 GLU E  247  ARG E  267  1                                  21    
HELIX   55 AG1 SER E  270  SER E  286  1                                  17    
HELIX   56 AG2 ARG E  292  ILE E  312  1                                  21    
HELIX   57 AG3 ILE E  312  GLN E  325  1                                  14    
HELIX   58 AG4 SER E  339  GLY E  353  1                                  15    
HELIX   59 AG5 GLU E  368  ALA E  379  1                                  12    
HELIX   60 AG6 ALA E  390  LEU E  395  1                                   6    
HELIX   61 AG7 VAL E  418  HIS E  430  1                                  13    
HELIX   62 AG8 GLU E  439  PHE E  443  5                                   5    
HELIX   63 AG9 ASP E  459  LEU E  463  5                                   5    
HELIX   64 AH1 SER E  511  VAL E  518  1                                   8    
HELIX   65 AH2 SER F  191  MET F  196  5                                   6    
HELIX   66 AH3 HIS F  204  GLN F  216  1                                  13    
HELIX   67 AH4 GLY F  221  ASP F  239  1                                  19    
HELIX   68 AH5 GLU F  247  ARG F  267  1                                  21    
HELIX   69 AH6 SER F  270  SER F  286  1                                  17    
HELIX   70 AH7 ARG F  292  ILE F  312  1                                  21    
HELIX   71 AH8 ILE F  312  GLN F  325  1                                  14    
HELIX   72 AH9 SER F  339  GLY F  353  1                                  15    
HELIX   73 AI1 GLU F  368  ALA F  379  1                                  12    
HELIX   74 AI2 ALA F  390  LEU F  395  1                                   6    
HELIX   75 AI3 VAL F  418  HIS F  430  1                                  13    
HELIX   76 AI4 GLU F  439  PHE F  443  5                                   5    
HELIX   77 AI5 ASP F  459  LEU F  463  5                                   5    
HELIX   78 AI6 SER F  511  VAL F  518  1                                   8    
HELIX   79 AI7 ASP G    3  GLU G   16  1                                  14    
HELIX   80 AI8 ALA G   21  ARG G   36  1                                  16    
HELIX   81 AI9 LEU G   45  ASP G   60  1                                  16    
HELIX   82 AJ1 SER G   62  SER G   77  1                                  16    
HELIX   83 AJ2 TYR G   86  HIS G  116  1                                  31    
HELIX   84 AJ3 THR G  117  ILE G  119  5                                   3    
HELIX   85 AJ4 SER G  131  ALA G  144  1                                  14    
HELIX   86 AJ5 SER G  160  HIS G  170  1                                  11    
HELIX   87 AJ6 LEU G  179  VAL G  183  5                                   5    
HELIX   88 AJ7 GLY G  211  GLN G  222  1                                  12    
HELIX   89 AJ8 PRO G  247  TYR G  252  1                                   6    
HELIX   90 AJ9 ALA G  277  ILE G  281  5                                   5    
HELIX   91 AK1 THR G  292  LEU G  305  1                                  14    
HELIX   92 AK2 ASP H    3  GLU H   16  1                                  14    
HELIX   93 AK3 ALA H   21  ARG H   36  1                                  16    
HELIX   94 AK4 LEU H   45  ASP H   60  1                                  16    
HELIX   95 AK5 SER H   62  SER H   77  1                                  16    
HELIX   96 AK6 TYR H   86  HIS H  116  1                                  31    
HELIX   97 AK7 THR H  117  ILE H  119  5                                   3    
HELIX   98 AK8 SER H  131  ALA H  144  1                                  14    
HELIX   99 AK9 SER H  160  HIS H  170  1                                  11    
HELIX  100 AL1 LEU H  179  VAL H  183  5                                   5    
HELIX  101 AL2 GLY H  211  GLN H  222  1                                  12    
HELIX  102 AL3 PRO H  247  TYR H  252  1                                   6    
HELIX  103 AL4 ALA H  277  ILE H  281  5                                   5    
HELIX  104 AL5 THR H  292  LEU H  305  1                                  14    
HELIX  105 AL6 ILE I   36  VAL I   46  1                                  11    
HELIX  106 AL7 ALA I   62  LYS I   68  1                                   7    
HELIX  107 AL8 GLY I   85  ILE I   93  1                                   9    
HELIX  108 AL9 TYR I   94  LEU I   97  5                                   4    
HELIX  109 AM1 LEU I  114  TYR I  124  1                                  11    
HELIX  110 AM2 LYS I  183  HIS I  190  1                                   8    
HELIX  111 AM3 LYS I  208  ASN I  218  1                                  11    
HELIX  112 AM4 GLU I  227  GLN I  236  1                                  10    
HELIX  113 AM5 TRP I  282  ASP I  292  1                                  11    
HELIX  114 AM6 ILE J   36  VAL J   46  1                                  11    
HELIX  115 AM7 ALA J   62  LYS J   68  1                                   7    
HELIX  116 AM8 GLY J   85  ILE J   93  1                                   9    
HELIX  117 AM9 TYR J   94  LEU J   97  5                                   4    
HELIX  118 AN1 LEU J  114  TYR J  124  1                                  11    
HELIX  119 AN2 LYS J  183  HIS J  190  1                                   8    
HELIX  120 AN3 LYS J  208  ASN J  218  1                                  11    
HELIX  121 AN4 GLU J  227  GLN J  236  1                                  10    
HELIX  122 AN5 TRP J  282  ASP J  292  1                                  11    
HELIX  123 AN6 SER L   48  ARG L   52  5                                   5    
HELIX  124 AN7 SER L   90  LEU L  118  1                                  29    
HELIX  125 AN8 LYS L  122  LYS L  142  1                                  21    
HELIX  126 AN9 GLY L  145  ASP L  158  1                                  14    
HELIX  127 AO1 PRO L  159  ASP L  163  5                                   5    
HELIX  128 AO2 ASN L  168  ASN L  180  1                                  13    
HELIX  129 AO3 SER M   48  ARG M   52  5                                   5    
HELIX  130 AO4 SER M   90  LEU M  118  1                                  29    
HELIX  131 AO5 LYS M  122  LYS M  142  1                                  21    
HELIX  132 AO6 GLY M  145  ASP M  158  1                                  14    
HELIX  133 AO7 PRO M  159  ASP M  163  5                                   5    
HELIX  134 AO8 ASN M  168  ASN M  180  1                                  13    
SHEET    1 AA1 4 ILE A 122  THR A 124  0                                        
SHEET    2 AA1 4 GLU A  90  CYS A  95  1  N  VAL A  93   O  ILE A 123           
SHEET    3 AA1 4 GLN A  44  VAL A  48  1  N  LEU A  47   O  PHE A  94           
SHEET    4 AA1 4 LEU A 149  TYR A 152  1  O  VAL A 151   N  VAL A  46           
SHEET    1 AA2 2 VAL A 155  SER A 157  0                                        
SHEET    2 AA2 2 GLY A 297  ARG A 299 -1  O  ALA A 298   N  ILE A 156           
SHEET    1 AA3 9 LEU A 244  ASP A 246  0                                        
SHEET    2 AA3 9 THR A 182  GLU A 187 -1  N  LYS A 186   O  LEU A 245           
SHEET    3 AA3 9 ILE A 287  THR A 292  1  O  HIS A 290   N  PHE A 185           
SHEET    4 AA3 9 ARG A 211  LYS A 217 -1  N  VAL A 212   O  ILE A 287           
SHEET    5 AA3 9 VAL A 201  ASP A 206 -1  N  ALA A 204   O  LEU A 213           
SHEET    6 AA3 9 VAL A 238  ARG A 241 -1  O  ARG A 241   N  VAL A 203           
SHEET    7 AA3 9 ARG I 192  HIS I 196 -1  O  ILE I 193   N  VAL A 240           
SHEET    8 AA3 9 PHE I 157  ASP I 161 -1  N  VAL I 160   O  ARG I 194           
SHEET    9 AA3 9 LEU I 167  ALA I 171 -1  O  LEU I 168   N  GLY I 159           
SHEET    1 AA4 2 PHE A 224  ALA A 225  0                                        
SHEET    2 AA4 2 VAL I 181  ILE I 182 -1  O  ILE I 182   N  PHE A 224           
SHEET    1 AA5 5 THR A 336  HIS A 337  0                                        
SHEET    2 AA5 5 TYR A 343  ARG A 344 -1  O  ARG A 344   N  THR A 336           
SHEET    3 AA5 5 LEU A 361  LEU A 362  1  O  LEU A 362   N  TYR A 343           
SHEET    4 AA5 5 VAL A 378  ILE A 379  1  O  ILE A 379   N  LEU A 361           
SHEET    5 AA5 5 TYR A 395  LEU A 396  1  O  LEU A 396   N  VAL A 378           
SHEET    1 AA6 5 ILE A 355  LEU A 356  0                                        
SHEET    2 AA6 5 PHE A 373  THR A 375  1  O  ILE A 374   N  ILE A 355           
SHEET    3 AA6 5 VAL A 390  ASP A 392  1  O  LEU A 391   N  THR A 375           
SHEET    4 AA6 5 GLN A 407  HIS A 409  1  O  ILE A 408   N  VAL A 390           
SHEET    5 AA6 5 THR A 424  LEU A 425  1  O  LEU A 425   N  GLN A 407           
SHEET    1 AA7 5 VAL A 367  ILE A 368  0                                        
SHEET    2 AA7 5 HIS A 384  ILE A 385  1  O  ILE A 385   N  VAL A 367           
SHEET    3 AA7 5 ARG A 401  VAL A 402  1  O  VAL A 402   N  HIS A 384           
SHEET    4 AA7 5 GLU A 418  VAL A 419  1  O  VAL A 419   N  ARG A 401           
SHEET    5 AA7 5 VAL A 436  VAL A 437  1  O  VAL A 437   N  GLU A 418           
SHEET    1 AA8 4 SER A 411  LEU A 413  0                                        
SHEET    2 AA8 4 SER A 429  LEU A 431  1  O  LEU A 431   N  LEU A 412           
SHEET    3 AA8 4 SER A 447  SER A 450  1  O  SER A 447   N  VAL A 430           
SHEET    4 AA8 4 GLU A 458  ASP A 459  1  O  GLU A 458   N  SER A 450           
SHEET    1 AA9 4 ILE B 122  THR B 124  0                                        
SHEET    2 AA9 4 GLU B  90  CYS B  95  1  N  VAL B  93   O  ILE B 123           
SHEET    3 AA9 4 GLN B  44  VAL B  48  1  N  LEU B  47   O  PHE B  94           
SHEET    4 AA9 4 LEU B 149  TYR B 152  1  O  VAL B 151   N  VAL B  46           
SHEET    1 AB1 2 VAL B 155  SER B 157  0                                        
SHEET    2 AB1 2 GLY B 297  ARG B 299 -1  O  ALA B 298   N  ILE B 156           
SHEET    1 AB2 9 LEU B 244  ASP B 246  0                                        
SHEET    2 AB2 9 THR B 182  GLU B 187 -1  N  LYS B 186   O  LEU B 245           
SHEET    3 AB2 9 ILE B 287  THR B 292  1  O  HIS B 290   N  PHE B 185           
SHEET    4 AB2 9 ARG B 211  LYS B 217 -1  N  VAL B 212   O  ILE B 287           
SHEET    5 AB2 9 VAL B 201  ASP B 206 -1  N  ALA B 204   O  LEU B 213           
SHEET    6 AB2 9 VAL B 238  ARG B 241 -1  O  ARG B 241   N  VAL B 203           
SHEET    7 AB2 9 ARG J 192  HIS J 196 -1  O  ILE J 193   N  VAL B 240           
SHEET    8 AB2 9 PHE J 157  ASP J 161 -1  N  VAL J 160   O  ARG J 194           
SHEET    9 AB2 9 LEU J 167  ALA J 171 -1  O  LEU J 168   N  GLY J 159           
SHEET    1 AB3 2 PHE B 224  ALA B 225  0                                        
SHEET    2 AB3 2 VAL J 181  ILE J 182 -1  O  ILE J 182   N  PHE B 224           
SHEET    1 AB4 5 THR B 336  HIS B 337  0                                        
SHEET    2 AB4 5 TYR B 343  ARG B 344 -1  O  ARG B 344   N  THR B 336           
SHEET    3 AB4 5 LEU B 361  LEU B 362  1  O  LEU B 362   N  TYR B 343           
SHEET    4 AB4 5 VAL B 378  ILE B 379  1  O  ILE B 379   N  LEU B 361           
SHEET    5 AB4 5 TYR B 395  LEU B 396  1  O  LEU B 396   N  VAL B 378           
SHEET    1 AB5 5 ILE B 355  LEU B 356  0                                        
SHEET    2 AB5 5 PHE B 373  THR B 375  1  O  ILE B 374   N  ILE B 355           
SHEET    3 AB5 5 VAL B 390  ASP B 392  1  O  LEU B 391   N  THR B 375           
SHEET    4 AB5 5 GLN B 407  HIS B 409  1  O  ILE B 408   N  VAL B 390           
SHEET    5 AB5 5 THR B 424  LEU B 425  1  O  LEU B 425   N  GLN B 407           
SHEET    1 AB6 5 VAL B 367  ILE B 368  0                                        
SHEET    2 AB6 5 HIS B 384  ILE B 385  1  O  ILE B 385   N  VAL B 367           
SHEET    3 AB6 5 ARG B 401  VAL B 402  1  O  VAL B 402   N  HIS B 384           
SHEET    4 AB6 5 GLU B 418  VAL B 419  1  O  VAL B 419   N  ARG B 401           
SHEET    5 AB6 5 VAL B 436  VAL B 437  1  O  VAL B 437   N  GLU B 418           
SHEET    1 AB7 4 SER B 411  LEU B 413  0                                        
SHEET    2 AB7 4 SER B 429  LEU B 431  1  O  LEU B 431   N  LEU B 412           
SHEET    3 AB7 4 SER B 447  SER B 450  1  O  SER B 447   N  VAL B 430           
SHEET    4 AB7 4 GLU B 458  ASP B 459  1  O  GLU B 458   N  SER B 450           
SHEET    1 AB8 8 GLY C 329  ASN C 331  0                                        
SHEET    2 AB8 8 LEU C 323  SER C 326 -1  N  PHE C 324   O  ASN C 331           
SHEET    3 AB8 8 LEU C 265  CYS C 268  1  N  VAL C 267   O  LEU C 323           
SHEET    4 AB8 8 LYS C 231  ILE C 234  1  N  VAL C 232   O  ILE C 266           
SHEET    5 AB8 8 VAL C 164  ILE C 168  1  O  VAL C 164   N  LYS C 231           
SHEET    6 AB8 8 HIS C 188  ALA C 192  1  O  ILE C 190   N  ILE C 165           
SHEET    7 AB8 8 THR C 214  MET C 217  1  O  THR C 215   N  VAL C 189           
SHEET    8 AB8 8 LEU F 482  LEU F 484  1  O  ARG F 483   N  VAL C 216           
SHEET    1 AB9 3 THR C 238  ILE C 239  0                                        
SHEET    2 AB9 3 LEU C 245  VAL C 248 -1  O  ARG C 246   N  THR C 238           
SHEET    3 AB9 3 PHE C 313  VAL C 316 -1  O  VAL C 316   N  LEU C 245           
SHEET    1 AC1 8 VAL C 306  VAL C 308  0                                        
SHEET    2 AC1 8 ALA F 383  LEU F 387  1  O  TYR F 385   N  SER C 307           
SHEET    3 AC1 8 ARG F 357  ASP F 362  1  N  VAL F 360   O  LEU F 386           
SHEET    4 AC1 8 VAL F 332  TYR F 336  1  N  ILE F 333   O  VAL F 359           
SHEET    5 AC1 8 LYS F 400  GLY F 404  1  O  LEU F 402   N  LEU F 334           
SHEET    6 AC1 8 VAL F 434  CYS F 437  1  O  LEU F 435   N  LEU F 403           
SHEET    7 AC1 8 LEU F 499  THR F 502  1  O  ILE F 501   N  VAL F 436           
SHEET    8 AC1 8 GLY F 505  PRO F 508 -1  O  ILE F 507   N  VAL F 500           
SHEET    1 AC2 8 GLY D 329  ASN D 331  0                                        
SHEET    2 AC2 8 LEU D 323  SER D 326 -1  N  PHE D 324   O  ASN D 331           
SHEET    3 AC2 8 LEU D 265  CYS D 268  1  N  VAL D 267   O  ILE D 325           
SHEET    4 AC2 8 LYS D 231  ILE D 234  1  N  ILE D 234   O  ILE D 266           
SHEET    5 AC2 8 VAL D 164  ILE D 168  1  N  VAL D 164   O  LYS D 231           
SHEET    6 AC2 8 HIS D 188  ALA D 192  1  O  ILE D 190   N  ILE D 165           
SHEET    7 AC2 8 THR D 214  MET D 217  1  O  THR D 215   N  VAL D 189           
SHEET    8 AC2 8 LEU E 482  LEU E 484  1  O  ARG E 483   N  VAL D 216           
SHEET    1 AC3 3 THR D 238  ILE D 239  0                                        
SHEET    2 AC3 3 LEU D 245  VAL D 248 -1  O  ARG D 246   N  THR D 238           
SHEET    3 AC3 3 PHE D 313  VAL D 316 -1  O  VAL D 316   N  LEU D 245           
SHEET    1 AC4 8 VAL D 306  VAL D 308  0                                        
SHEET    2 AC4 8 ALA E 383  LEU E 387  1  O  TYR E 385   N  SER D 307           
SHEET    3 AC4 8 ARG E 357  ASP E 362  1  N  VAL E 360   O  LEU E 386           
SHEET    4 AC4 8 VAL E 332  TYR E 336  1  N  ILE E 333   O  VAL E 359           
SHEET    5 AC4 8 LYS E 400  GLY E 404  1  O  LEU E 402   N  LEU E 334           
SHEET    6 AC4 8 VAL E 434  CYS E 437  1  O  LEU E 435   N  LEU E 403           
SHEET    7 AC4 8 LEU E 499  THR E 502  1  O  ILE E 501   N  VAL E 436           
SHEET    8 AC4 8 GLY E 505  PRO E 508 -1  O  ILE E 507   N  VAL E 500           
SHEET    1 AC5 3 ALA E 407  LEU E 408  0                                        
SHEET    2 AC5 3 VAL E 414  ARG E 417 -1  O  MET E 415   N  ALA E 407           
SHEET    3 AC5 3 TYR E 489  THR E 492 -1  O  ASP E 490   N  SER E 416           
SHEET    1 AC6 3 ALA F 407  LEU F 408  0                                        
SHEET    2 AC6 3 VAL F 414  ARG F 417 -1  O  MET F 415   N  ALA F 407           
SHEET    3 AC6 3 TYR F 489  THR F 492 -1  O  ASP F 490   N  SER F 416           
SHEET    1 AC7 7 VAL G 175  VAL G 178  0                                        
SHEET    2 AC7 7 PHE G 148  THR G 153  1  N  VAL G 150   O  THR G 176           
SHEET    3 AC7 7 ALA G 123  THR G 127  1  N  ILE G 125   O  TYR G 151           
SHEET    4 AC7 7 LEU G 192  VAL G 195  1  O  LEU G 192   N  THR G 124           
SHEET    5 AC7 7 PHE G 226  VAL G 229  1  O  TYR G 227   N  VAL G 193           
SHEET    6 AC7 7 LEU G 283  THR G 286  1  O  PHE G 285   N  VAL G 228           
SHEET    7 AC7 7 GLY G 289  LEU G 291 -1  O  GLY G 289   N  THR G 286           
SHEET    1 AC8 3 GLY G 199  VAL G 200  0                                        
SHEET    2 AC8 3 ILE G 206  ASN G 208 -1  O  ILE G 207   N  GLY G 199           
SHEET    3 AC8 3 ASP G 274  THR G 276 -1  O  THR G 276   N  ILE G 206           
SHEET    1 AC9 7 VAL H 175  VAL H 178  0                                        
SHEET    2 AC9 7 PHE H 148  THR H 153  1  N  VAL H 150   O  THR H 176           
SHEET    3 AC9 7 ALA H 123  THR H 127  1  N  ILE H 125   O  TYR H 151           
SHEET    4 AC9 7 LEU H 192  VAL H 195  1  O  LEU H 192   N  THR H 124           
SHEET    5 AC9 7 PHE H 226  VAL H 229  1  O  TYR H 227   N  VAL H 193           
SHEET    6 AC9 7 LEU H 283  THR H 286  1  O  PHE H 285   N  VAL H 228           
SHEET    7 AC9 7 GLY H 289  LEU H 291 -1  O  GLY H 289   N  THR H 286           
SHEET    1 AD1 3 GLY H 199  VAL H 200  0                                        
SHEET    2 AD1 3 ILE H 206  ASN H 208 -1  O  ILE H 207   N  GLY H 199           
SHEET    3 AD1 3 ASP H 274  THR H 276 -1  O  THR H 276   N  ILE H 206           
SHEET    1 AD2 4 ILE I  75  ILE I  78  0                                        
SHEET    2 AD2 4 VAL I  51  VAL I  54  1  N  VAL I  53   O  VAL I  76           
SHEET    3 AD2 4 PHE I   3  MET I   8  1  N  ALA I   5   O  ILE I  52           
SHEET    4 AD2 4 ASP I 100  SER I 105  1  O  LEU I 104   N  VAL I   6           
SHEET    1 AD3 3 VAL I 200  ASP I 201  0                                        
SHEET    2 AD3 3 LEU I 128  ARG I 133 -1  N  ARG I 133   O  VAL I 200           
SHEET    3 AD3 3 ILE I 263  ILE I 267  1  O  TYR I 264   N  LEU I 128           
SHEET    1 AD4 4 ILE J  75  ILE J  78  0                                        
SHEET    2 AD4 4 VAL J  51  VAL J  54  1  N  VAL J  53   O  VAL J  76           
SHEET    3 AD4 4 PHE J   3  MET J   8  1  N  ALA J   5   O  ILE J  52           
SHEET    4 AD4 4 ASP J 100  SER J 105  1  O  LEU J 104   N  VAL J   6           
SHEET    1 AD5 3 VAL J 200  ASP J 201  0                                        
SHEET    2 AD5 3 LEU J 128  ARG J 133 -1  N  ARG J 133   O  VAL J 200           
SHEET    3 AD5 3 ILE J 263  ILE J 267  1  O  TYR J 264   N  LEU J 128           
SHEET    1 AD6 6 VAL L  18  ILE L  26  0                                        
SHEET    2 AD6 6 GLY L  30  LEU L  35 -1  O  SER L  34   N  ASN L  22           
SHEET    3 AD6 6 ILE L  41  LEU L  46 -1  O  ILE L  41   N  LEU L  35           
SHEET    4 AD6 6 TYR L  81  SER L  85  1  O  LEU L  84   N  MET L  44           
SHEET    5 AD6 6 ASN L  67  ASP L  76 -1  N  ARG L  74   O  ASP L  83           
SHEET    6 AD6 6 VAL L  18  ILE L  26 -1  N  VAL L  19   O  VAL L  70           
SHEET    1 AD7 6 VAL M  18  ILE M  26  0                                        
SHEET    2 AD7 6 GLY M  30  LEU M  35 -1  O  SER M  34   N  ASN M  22           
SHEET    3 AD7 6 ILE M  41  LEU M  46 -1  O  ILE M  41   N  LEU M  35           
SHEET    4 AD7 6 TYR M  81  SER M  85  1  O  LEU M  84   N  MET M  44           
SHEET    5 AD7 6 ASN M  67  ASP M  76 -1  N  ARG M  74   O  ASP M  83           
SHEET    6 AD7 6 VAL M  18  ILE M  26 -1  N  VAL M  19   O  VAL M  70           
LINK         C   LEU L  50                 N   SEP L  51     1555   1555  1.33  
LINK         C   SEP L  51                 N   ARG L  52     1555   1555  1.33  
LINK         C   LEU M  50                 N   SEP M  51     1555   1555  1.33  
LINK         C   SEP M  51                 N   ARG M  52     1555   1555  1.33  
CISPEP   1 PHE A   57    PRO A   58          0        -3.01                     
CISPEP   2 TYR A  319    PRO A  320          0        10.22                     
CISPEP   3 PHE B   57    PRO B   58          0        -2.91                     
CISPEP   4 TYR B  319    PRO B  320          0        10.19                     
CISPEP   5 GLY C   27    PRO C   28          0        -1.93                     
CISPEP   6 GLY D   27    PRO D   28          0        -0.94                     
CISPEP   7 ARG E  364    PRO E  365          0        -4.82                     
CISPEP   8 ARG F  364    PRO F  365          0        -4.69                     
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1           1          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      1.000000  0.000000  0.000000        0.00000                         
SCALE2      0.000000  1.000000  0.000000        0.00000                         
SCALE3      0.000000  0.000000  1.000000        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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