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Database: PDB
Entry: 6PE9
LinkDB: 6PE9
Original site: 6PE9 
HEADER    IMMUNE SYSTEM                           20-JUN-19   6PE9              
TITLE     CRYSTAL STRUCTURE OF CD40 COMPLEXED TO FAB516                         
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: FAB HEAVY CHAIN;                                           
COMPND   3 CHAIN: A, C, E, H, K;                                                
COMPND   4 ENGINEERED: YES;                                                     
COMPND   5 MOL_ID: 2;                                                           
COMPND   6 MOLECULE: FAB LIGHT CHAIN;                                           
COMPND   7 CHAIN: B, D, F, L, M;                                                
COMPND   8 ENGINEERED: YES;                                                     
COMPND   9 MOL_ID: 3;                                                           
COMPND  10 MOLECULE: TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 5;       
COMPND  11 CHAIN: G, I, J, U, V;                                                
COMPND  12 SYNONYM: B-CELL SURFACE ANTIGEN CD40,BP50,CD40L RECEPTOR,CDW40;      
COMPND  13 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   3 ORGANISM_COMMON: HUMAN;                                              
SOURCE   4 ORGANISM_TAXID: 9606;                                                
SOURCE   5 EXPRESSION_SYSTEM: HOMO SAPIENS;                                     
SOURCE   6 EXPRESSION_SYSTEM_COMMON: HUMAN;                                     
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 9606;                                       
SOURCE   8 EXPRESSION_SYSTEM_CELL_LINE: HEK293;                                 
SOURCE   9 MOL_ID: 2;                                                           
SOURCE  10 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  11 ORGANISM_COMMON: HUMAN;                                              
SOURCE  12 ORGANISM_TAXID: 9606;                                                
SOURCE  13 EXPRESSION_SYSTEM: HOMO SAPIENS;                                     
SOURCE  14 EXPRESSION_SYSTEM_COMMON: HUMAN;                                     
SOURCE  15 EXPRESSION_SYSTEM_TAXID: 9606;                                       
SOURCE  16 EXPRESSION_SYSTEM_CELL_LINE: HEK293;                                 
SOURCE  17 MOL_ID: 3;                                                           
SOURCE  18 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  19 ORGANISM_COMMON: HUMAN;                                              
SOURCE  20 ORGANISM_TAXID: 9606;                                                
SOURCE  21 GENE: CD40, TNFRSF5;                                                 
SOURCE  22 EXPRESSION_SYSTEM: HOMO SAPIENS;                                     
SOURCE  23 EXPRESSION_SYSTEM_COMMON: HUMAN;                                     
SOURCE  24 EXPRESSION_SYSTEM_TAXID: 9606;                                       
SOURCE  25 EXPRESSION_SYSTEM_CELL_LINE: HEK293                                  
KEYWDS    CD40, FAB, COMPLEX, IMMUNE SYSTEM                                     
EXPDTA    X-RAY DIFFRACTION                                                     
AUTHOR    M.A.ARGIRIADI                                                         
REVDAT   1   14-AUG-19 6PE9    0                                                
JRNL        AUTH   M.A.ARGIRIADI,L.BENATUIL,I.DUBROVSKA,D.A.EGAN,L.GAO,         
JRNL        AUTH 2 A.GREISCHAR,J.HARDMAN,J.HARLAN,R.B.IYER,R.A.JUDGE,M.LAKE,    
JRNL        AUTH 3 D.C.PERRON,R.SADHUKHAN,B.SIELAFF,S.SOUSA,R.WANG,B.L.MCRAE    
JRNL        TITL   CD40/ANTI-CD40 ANTIBODY COMPLEXES WHICH ILLUSTRATE AGONIST   
JRNL        TITL 2 AND ANTAGONIST STRUCTURAL SWITCHES.                          
JRNL        REF    BMC MOL CELL BIOL             V.  20    29 2019              
JRNL        REFN                   ISSN 2661-8850                               
JRNL        PMID   31382872                                                     
JRNL        DOI    10.1186/S12860-019-0213-4                                    
REMARK   2                                                                      
REMARK   2 RESOLUTION.    3.13 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   PROGRAM     : PHENIX (1.11.1_2575: ???)                            
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VINCENT CHEN,IAN            
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-KUNSTLEVE,           
REMARK   3               : LI-WEI HUNG,ROBERT IMMORMINO,TOM IOERGER,            
REMARK   3               : AIRLIE MCCOY,ERIK MCKEE,NIGEL MORIARTY,              
REMARK   3               : REETAL PAI,RANDY READ,JANE RICHARDSON,               
REMARK   3               : DAVID RICHARDSON,TOD ROMO,JIM SACCHETTINI,           
REMARK   3               : NICHOLAS SAUTER,JACOB SMITH,LAURENT                  
REMARK   3               : STORONI,TOM TERWILLIGER,PETER ZWART                  
REMARK   3                                                                      
REMARK   3    REFINEMENT TARGET : NULL                                          
REMARK   3                                                                      
REMARK   3  DATA USED IN REFINEMENT.                                            
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 3.13                           
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 35.34                          
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : 1.350                          
REMARK   3   COMPLETENESS FOR RANGE        (%) : 99.4                           
REMARK   3   NUMBER OF REFLECTIONS             : 107879                         
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT.                                     
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.218                           
REMARK   3   R VALUE            (WORKING SET) : 0.216                           
REMARK   3   FREE R VALUE                     : 0.255                           
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 5.050                           
REMARK   3   FREE R VALUE TEST SET COUNT      : 5445                            
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).                           
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE        
REMARK   3     1 35.3403 -  9.6612    0.95     3317   196  0.2693 0.3017        
REMARK   3     2  9.6612 -  7.6944    0.98     3377   181  0.2136 0.2315        
REMARK   3     3  7.6944 -  6.7294    0.99     3455   154  0.2322 0.2682        
REMARK   3     4  6.7294 -  6.1176    0.99     3409   185  0.2192 0.2556        
REMARK   3     5  6.1176 -  5.6810    0.99     3407   177  0.2143 0.2545        
REMARK   3     6  5.6810 -  5.3473    0.99     3452   146  0.1920 0.2059        
REMARK   3     7  5.3473 -  5.0803    1.00     3413   191  0.1868 0.2248        
REMARK   3     8  5.0803 -  4.8597    0.99     3425   172  0.1740 0.2369        
REMARK   3     9  4.8597 -  4.6731    0.99     3420   201  0.1731 0.2055        
REMARK   3    10  4.6731 -  4.5122    0.99     3412   185  0.1776 0.2166        
REMARK   3    11  4.5122 -  4.3713    0.99     3421   169  0.1711 0.2123        
REMARK   3    12  4.3713 -  4.2466    0.99     3405   171  0.1785 0.2270        
REMARK   3    13  4.2466 -  4.1350    0.99     3436   168  0.1866 0.1994        
REMARK   3    14  4.1350 -  4.0342    1.00     3411   173  0.1932 0.2205        
REMARK   3    15  4.0342 -  3.9427    1.00     3387   199  0.1946 0.2306        
REMARK   3    16  3.9427 -  3.8589    1.00     3393   202  0.2008 0.2263        
REMARK   3    17  3.8589 -  3.7818    1.00     3442   193  0.2129 0.2538        
REMARK   3    18  3.7818 -  3.7105    1.00     3415   165  0.2177 0.2685        
REMARK   3    19  3.7105 -  3.6443    1.00     3457   170  0.2234 0.2817        
REMARK   3    20  3.6443 -  3.5826    1.00     3403   174  0.2289 0.2491        
REMARK   3    21  3.5826 -  3.5248    1.00     3443   195  0.2253 0.2736        
REMARK   3    22  3.5248 -  3.4706    1.00     3368   194  0.2353 0.2930        
REMARK   3    23  3.4706 -  3.4196    1.00     3445   200  0.2540 0.3046        
REMARK   3    24  3.4196 -  3.3715    1.00     3387   176  0.2548 0.3459        
REMARK   3    25  3.3715 -  3.3260    1.00     3423   191  0.2690 0.2944        
REMARK   3    26  3.3260 -  3.2828    1.00     3415   196  0.2669 0.3209        
REMARK   3    27  3.2828 -  3.2418    1.00     3443   206  0.2738 0.3230        
REMARK   3    28  3.2418 -  3.2028    1.00     3350   187  0.2817 0.3231        
REMARK   3    29  3.2028 -  3.1656    1.00     3451   158  0.2951 0.3530        
REMARK   3    30  3.1656 -  3.1300    1.00     3452   170  0.3127 0.3787        
REMARK   3                                                                      
REMARK   3  BULK SOLVENT MODELLING.                                             
REMARK   3   METHOD USED        : NULL                                          
REMARK   3   SOLVENT RADIUS     : 1.11                                          
REMARK   3   SHRINKAGE RADIUS   : 0.90                                          
REMARK   3   K_SOL              : NULL                                          
REMARK   3   B_SOL              : NULL                                          
REMARK   3                                                                      
REMARK   3  ERROR ESTIMATES.                                                    
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : 0.420            
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 24.800           
REMARK   3                                                                      
REMARK   3  B VALUES.                                                           
REMARK   3   FROM WILSON PLOT           (A**2) : NULL                           
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : NULL                           
REMARK   3   OVERALL ANISOTROPIC B VALUE.                                       
REMARK   3    B11 (A**2) : NULL                                                 
REMARK   3    B22 (A**2) : NULL                                                 
REMARK   3    B33 (A**2) : NULL                                                 
REMARK   3    B12 (A**2) : NULL                                                 
REMARK   3    B13 (A**2) : NULL                                                 
REMARK   3    B23 (A**2) : NULL                                                 
REMARK   3                                                                      
REMARK   3  TWINNING INFORMATION.                                               
REMARK   3   FRACTION: NULL                                                     
REMARK   3   OPERATOR: NULL                                                     
REMARK   3                                                                      
REMARK   3  DEVIATIONS FROM IDEAL VALUES.                                       
REMARK   3                 RMSD          COUNT                                  
REMARK   3   BOND      :  0.010          18980                                  
REMARK   3   ANGLE     :  1.134          25872                                  
REMARK   3   CHIRALITY :  0.061           2906                                  
REMARK   3   PLANARITY :  0.006           3323                                  
REMARK   3   DIHEDRAL  :  3.075          11180                                  
REMARK   3                                                                      
REMARK   3  TLS DETAILS                                                         
REMARK   3   NUMBER OF TLS GROUPS  : NULL                                       
REMARK   3                                                                      
REMARK   3  NCS DETAILS                                                         
REMARK   3   NUMBER OF NCS GROUPS : NULL                                        
REMARK   3                                                                      
REMARK   3  OTHER REFINEMENT REMARKS: NULL                                      
REMARK   4                                                                      
REMARK   4 6PE9 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 21-JUN-19.                  
REMARK 100 THE DEPOSITION ID IS D_1000242277.                                   
REMARK 200                                                                      
REMARK 200 EXPERIMENTAL DETAILS                                                 
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION                  
REMARK 200  DATE OF DATA COLLECTION        : 14-APR-16                          
REMARK 200  TEMPERATURE           (KELVIN) : 100                                
REMARK 200  PH                             : NULL                               
REMARK 200  NUMBER OF CRYSTALS USED        : 1                                  
REMARK 200                                                                      
REMARK 200  SYNCHROTRON              (Y/N) : Y                                  
REMARK 200  RADIATION SOURCE               : APS                                
REMARK 200  BEAMLINE                       : 17-ID                              
REMARK 200  X-RAY GENERATOR MODEL          : NULL                               
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M                                  
REMARK 200  WAVELENGTH OR RANGE        (A) : 1.00                               
REMARK 200  MONOCHROMATOR                  : NULL                               
REMARK 200  OPTICS                         : NULL                               
REMARK 200                                                                      
REMARK 200  DETECTOR TYPE                  : PIXEL                              
REMARK 200  DETECTOR MANUFACTURER          : DECTRIS PILATUS 6M                 
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : XDS                                
REMARK 200  DATA SCALING SOFTWARE          : AUTOPROC                           
REMARK 200                                                                      
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 108254                             
REMARK 200  RESOLUTION RANGE HIGH      (A) : 3.130                              
REMARK 200  RESOLUTION RANGE LOW       (A) : 167.500                            
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL                               
REMARK 200                                                                      
REMARK 200 OVERALL.                                                             
REMARK 200  COMPLETENESS FOR RANGE     (%) : 99.4                               
REMARK 200  DATA REDUNDANCY                : 3.400                              
REMARK 200  R MERGE                    (I) : NULL                               
REMARK 200  R SYM                      (I) : NULL                               
REMARK 200  <I/SIGMA(I)> FOR THE DATA SET  : 11.2000                            
REMARK 200                                                                      
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.                                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 3.13                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 3.14                     
REMARK 200  COMPLETENESS FOR SHELL     (%) : NULL                               
REMARK 200  DATA REDUNDANCY IN SHELL       : NULL                               
REMARK 200  R MERGE FOR SHELL          (I) : NULL                               
REMARK 200  R SYM FOR SHELL            (I) : NULL                               
REMARK 200  <I/SIGMA(I)> FOR SHELL         : NULL                               
REMARK 200                                                                      
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH                              
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT        
REMARK 200 SOFTWARE USED: PHASER                                                
REMARK 200 STARTING MODEL: 6PE8                                                 
REMARK 200                                                                      
REMARK 200 REMARK: NULL                                                         
REMARK 280                                                                      
REMARK 280 CRYSTAL                                                              
REMARK 280 SOLVENT CONTENT, VS   (%): 73.74                                     
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 4.68                     
REMARK 280                                                                      
REMARK 280 CRYSTALLIZATION CONDITIONS: 1.6M AMMONIUM SULFATE 2% W/V PEG1000,    
REMARK 280  100 MM HEPES SODIUM SALT PH 7.5, VAPOR DIFFUSION, TEMPERATURE       
REMARK 280  296.15K                                                             
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY                                            
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: C 1 2 1                          
REMARK 290                                                                      
REMARK 290      SYMOP   SYMMETRY                                                
REMARK 290     NNNMMM   OPERATOR                                                
REMARK 290       1555   X,Y,Z                                                   
REMARK 290       2555   -X,Y,-Z                                                 
REMARK 290       3555   X+1/2,Y+1/2,Z                                           
REMARK 290       4555   -X+1/2,Y+1/2,-Z                                         
REMARK 290                                                                      
REMARK 290     WHERE NNN -> OPERATOR NUMBER                                     
REMARK 290           MMM -> TRANSLATION VECTOR                                  
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS                            
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM             
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY                
REMARK 290 RELATED MOLECULES.                                                   
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   2  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   2  0.000000  0.000000 -1.000000        0.00000            
REMARK 290   SMTRY1   3  1.000000  0.000000  0.000000      127.42000            
REMARK 290   SMTRY2   3  0.000000  1.000000  0.000000      112.01750            
REMARK 290   SMTRY3   3  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   4 -1.000000  0.000000  0.000000      127.42000            
REMARK 290   SMTRY2   4  0.000000  1.000000  0.000000      112.01750            
REMARK 290   SMTRY3   4  0.000000  0.000000 -1.000000        0.00000            
REMARK 290                                                                      
REMARK 290 REMARK: NULL                                                         
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1, 2, 3, 4, 5                                           
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TRIMERIC                          
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B                                  
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350 APPLY THE FOLLOWING TO CHAINS: I                                     
REMARK 350   BIOMT1   2 -1.000000  0.000000  0.000000      606.10392            
REMARK 350   BIOMT2   2  0.000000  1.000000  0.000000      112.01750            
REMARK 350   BIOMT3   2  0.000000  0.000000 -1.000000      220.54854            
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 2                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TRIMERIC                          
REMARK 350 APPLY THE FOLLOWING TO CHAINS: C, D, G                               
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 3                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TRIMERIC                          
REMARK 350 APPLY THE FOLLOWING TO CHAINS: E, F, U                               
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 4                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TRIMERIC                          
REMARK 350 APPLY THE FOLLOWING TO CHAINS: H, L, V                               
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 5                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TRIMERIC                          
REMARK 350 APPLY THE FOLLOWING TO CHAINS: J, K, M                               
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     SER A   131                                                      
REMARK 465     LYS A   132                                                      
REMARK 465     SER A   133                                                      
REMARK 465     THR A   134                                                      
REMARK 465     SER A   135                                                      
REMARK 465     GLY A   136                                                      
REMARK 465     ASP A   220                                                      
REMARK 465     LYS A   221                                                      
REMARK 465     THR A   222                                                      
REMARK 465     HIS A   223                                                      
REMARK 465     CYS B   220                                                      
REMARK 465     SER C   131                                                      
REMARK 465     LYS C   132                                                      
REMARK 465     SER C   133                                                      
REMARK 465     THR C   134                                                      
REMARK 465     SER C   135                                                      
REMARK 465     GLY C   136                                                      
REMARK 465     ASP C   220                                                      
REMARK 465     LYS C   221                                                      
REMARK 465     THR C   222                                                      
REMARK 465     HIS C   223                                                      
REMARK 465     SER E   131                                                      
REMARK 465     LYS E   132                                                      
REMARK 465     SER E   133                                                      
REMARK 465     THR E   134                                                      
REMARK 465     SER E   135                                                      
REMARK 465     GLY E   136                                                      
REMARK 465     LYS E   217                                                      
REMARK 465     SER E   218                                                      
REMARK 465     CYS E   219                                                      
REMARK 465     ASP E   220                                                      
REMARK 465     LYS E   221                                                      
REMARK 465     THR E   222                                                      
REMARK 465     HIS E   223                                                      
REMARK 465     GLU G    21                                                      
REMARK 465     PRO G    22                                                      
REMARK 465     PRO G    23                                                      
REMARK 465     THR G    24                                                      
REMARK 465     ALA G    25                                                      
REMARK 465     PRO G   147                                                      
REMARK 465     VAL G   148                                                      
REMARK 465     GLY G   149                                                      
REMARK 465     PHE G   150                                                      
REMARK 465     PHE G   151                                                      
REMARK 465     SER G   152                                                      
REMARK 465     ASN G   153                                                      
REMARK 465     VAL G   154                                                      
REMARK 465     SER G   155                                                      
REMARK 465     SER G   156                                                      
REMARK 465     ALA G   157                                                      
REMARK 465     PHE G   158                                                      
REMARK 465     GLU G   159                                                      
REMARK 465     LYS G   160                                                      
REMARK 465     CYS G   161                                                      
REMARK 465     HIS G   162                                                      
REMARK 465     PRO G   163                                                      
REMARK 465     TRP G   164                                                      
REMARK 465     THR G   165                                                      
REMARK 465     SER G   166                                                      
REMARK 465     CYS G   167                                                      
REMARK 465     GLU G   168                                                      
REMARK 465     THR G   169                                                      
REMARK 465     LYS G   170                                                      
REMARK 465     ASP G   171                                                      
REMARK 465     LEU G   172                                                      
REMARK 465     VAL G   173                                                      
REMARK 465     VAL G   174                                                      
REMARK 465     GLN G   175                                                      
REMARK 465     GLN G   176                                                      
REMARK 465     ALA G   177                                                      
REMARK 465     GLY G   178                                                      
REMARK 465     THR G   179                                                      
REMARK 465     ASN G   180                                                      
REMARK 465     LYS G   181                                                      
REMARK 465     THR G   182                                                      
REMARK 465     ASP G   183                                                      
REMARK 465     VAL G   184                                                      
REMARK 465     VAL G   185                                                      
REMARK 465     CYS G   186                                                      
REMARK 465     GLY G   187                                                      
REMARK 465     PRO G   188                                                      
REMARK 465     GLN G   189                                                      
REMARK 465     ASP G   190                                                      
REMARK 465     ARG G   191                                                      
REMARK 465     LEU G   192                                                      
REMARK 465     ARG G   193                                                      
REMARK 465     LYS H   132                                                      
REMARK 465     SER H   133                                                      
REMARK 465     THR H   134                                                      
REMARK 465     SER H   135                                                      
REMARK 465     GLY H   136                                                      
REMARK 465     ASP H   220                                                      
REMARK 465     LYS H   221                                                      
REMARK 465     THR H   222                                                      
REMARK 465     HIS H   223                                                      
REMARK 465     GLU I    21                                                      
REMARK 465     PRO I    22                                                      
REMARK 465     PRO I    23                                                      
REMARK 465     GLU I   107                                                      
REMARK 465     HIS I   122                                                      
REMARK 465     ARG I   123                                                      
REMARK 465     SER I   124                                                      
REMARK 465     CYS I   125                                                      
REMARK 465     SER I   126                                                      
REMARK 465     PRO I   127                                                      
REMARK 465     GLY I   128                                                      
REMARK 465     PHE I   129                                                      
REMARK 465     GLY I   130                                                      
REMARK 465     VAL I   131                                                      
REMARK 465     LYS I   132                                                      
REMARK 465     GLN I   133                                                      
REMARK 465     ILE I   134                                                      
REMARK 465     ALA I   135                                                      
REMARK 465     THR I   136                                                      
REMARK 465     GLY I   137                                                      
REMARK 465     VAL I   138                                                      
REMARK 465     SER I   139                                                      
REMARK 465     ASP I   140                                                      
REMARK 465     THR I   141                                                      
REMARK 465     ILE I   142                                                      
REMARK 465     CYS I   143                                                      
REMARK 465     GLU I   144                                                      
REMARK 465     PRO I   145                                                      
REMARK 465     CYS I   146                                                      
REMARK 465     PRO I   147                                                      
REMARK 465     VAL I   148                                                      
REMARK 465     GLY I   149                                                      
REMARK 465     PHE I   150                                                      
REMARK 465     PHE I   151                                                      
REMARK 465     SER I   152                                                      
REMARK 465     ASN I   153                                                      
REMARK 465     VAL I   154                                                      
REMARK 465     SER I   155                                                      
REMARK 465     SER I   156                                                      
REMARK 465     ALA I   157                                                      
REMARK 465     PHE I   158                                                      
REMARK 465     GLU I   159                                                      
REMARK 465     LYS I   160                                                      
REMARK 465     CYS I   161                                                      
REMARK 465     HIS I   162                                                      
REMARK 465     PRO I   163                                                      
REMARK 465     TRP I   164                                                      
REMARK 465     THR I   165                                                      
REMARK 465     SER I   166                                                      
REMARK 465     CYS I   167                                                      
REMARK 465     GLU I   168                                                      
REMARK 465     THR I   169                                                      
REMARK 465     LYS I   170                                                      
REMARK 465     ASP I   171                                                      
REMARK 465     LEU I   172                                                      
REMARK 465     VAL I   173                                                      
REMARK 465     VAL I   174                                                      
REMARK 465     GLN I   175                                                      
REMARK 465     GLN I   176                                                      
REMARK 465     ALA I   177                                                      
REMARK 465     GLY I   178                                                      
REMARK 465     THR I   179                                                      
REMARK 465     ASN I   180                                                      
REMARK 465     LYS I   181                                                      
REMARK 465     THR I   182                                                      
REMARK 465     ASP I   183                                                      
REMARK 465     VAL I   184                                                      
REMARK 465     VAL I   185                                                      
REMARK 465     CYS I   186                                                      
REMARK 465     GLY I   187                                                      
REMARK 465     PRO I   188                                                      
REMARK 465     GLN I   189                                                      
REMARK 465     ASP I   190                                                      
REMARK 465     ARG I   191                                                      
REMARK 465     LEU I   192                                                      
REMARK 465     ARG I   193                                                      
REMARK 465     GLU J    21                                                      
REMARK 465     PRO J    22                                                      
REMARK 465     PRO J    23                                                      
REMARK 465     ASN J    34                                                      
REMARK 465     GLU J   106                                                      
REMARK 465     GLU J   107                                                      
REMARK 465     GLY J   108                                                      
REMARK 465     TRP J   109                                                      
REMARK 465     HIS J   110                                                      
REMARK 465     CYS J   111                                                      
REMARK 465     THR J   112                                                      
REMARK 465     SER J   113                                                      
REMARK 465     GLU J   114                                                      
REMARK 465     ALA J   115                                                      
REMARK 465     CYS J   116                                                      
REMARK 465     GLU J   117                                                      
REMARK 465     SER J   118                                                      
REMARK 465     CYS J   119                                                      
REMARK 465     VAL J   120                                                      
REMARK 465     LEU J   121                                                      
REMARK 465     HIS J   122                                                      
REMARK 465     ARG J   123                                                      
REMARK 465     SER J   124                                                      
REMARK 465     CYS J   125                                                      
REMARK 465     SER J   126                                                      
REMARK 465     PRO J   127                                                      
REMARK 465     GLY J   128                                                      
REMARK 465     PHE J   129                                                      
REMARK 465     GLY J   130                                                      
REMARK 465     VAL J   131                                                      
REMARK 465     LYS J   132                                                      
REMARK 465     GLN J   133                                                      
REMARK 465     ILE J   134                                                      
REMARK 465     ALA J   135                                                      
REMARK 465     THR J   136                                                      
REMARK 465     GLY J   137                                                      
REMARK 465     VAL J   138                                                      
REMARK 465     SER J   139                                                      
REMARK 465     ASP J   140                                                      
REMARK 465     THR J   141                                                      
REMARK 465     ILE J   142                                                      
REMARK 465     CYS J   143                                                      
REMARK 465     GLU J   144                                                      
REMARK 465     PRO J   145                                                      
REMARK 465     CYS J   146                                                      
REMARK 465     PRO J   147                                                      
REMARK 465     VAL J   148                                                      
REMARK 465     GLY J   149                                                      
REMARK 465     PHE J   150                                                      
REMARK 465     PHE J   151                                                      
REMARK 465     SER J   152                                                      
REMARK 465     ASN J   153                                                      
REMARK 465     VAL J   154                                                      
REMARK 465     SER J   155                                                      
REMARK 465     SER J   156                                                      
REMARK 465     ALA J   157                                                      
REMARK 465     PHE J   158                                                      
REMARK 465     GLU J   159                                                      
REMARK 465     LYS J   160                                                      
REMARK 465     CYS J   161                                                      
REMARK 465     HIS J   162                                                      
REMARK 465     PRO J   163                                                      
REMARK 465     TRP J   164                                                      
REMARK 465     THR J   165                                                      
REMARK 465     SER J   166                                                      
REMARK 465     CYS J   167                                                      
REMARK 465     GLU J   168                                                      
REMARK 465     THR J   169                                                      
REMARK 465     LYS J   170                                                      
REMARK 465     ASP J   171                                                      
REMARK 465     LEU J   172                                                      
REMARK 465     VAL J   173                                                      
REMARK 465     VAL J   174                                                      
REMARK 465     GLN J   175                                                      
REMARK 465     GLN J   176                                                      
REMARK 465     ALA J   177                                                      
REMARK 465     GLY J   178                                                      
REMARK 465     THR J   179                                                      
REMARK 465     ASN J   180                                                      
REMARK 465     LYS J   181                                                      
REMARK 465     THR J   182                                                      
REMARK 465     ASP J   183                                                      
REMARK 465     VAL J   184                                                      
REMARK 465     VAL J   185                                                      
REMARK 465     CYS J   186                                                      
REMARK 465     GLY J   187                                                      
REMARK 465     PRO J   188                                                      
REMARK 465     GLN J   189                                                      
REMARK 465     ASP J   190                                                      
REMARK 465     ARG J   191                                                      
REMARK 465     LEU J   192                                                      
REMARK 465     ARG J   193                                                      
REMARK 465     ALA K   117                                                      
REMARK 465     SER K   118                                                      
REMARK 465     THR K   119                                                      
REMARK 465     LYS K   120                                                      
REMARK 465     GLY K   121                                                      
REMARK 465     PRO K   122                                                      
REMARK 465     SER K   123                                                      
REMARK 465     VAL K   124                                                      
REMARK 465     PHE K   125                                                      
REMARK 465     PRO K   126                                                      
REMARK 465     LEU K   127                                                      
REMARK 465     ALA K   128                                                      
REMARK 465     PRO K   129                                                      
REMARK 465     SER K   130                                                      
REMARK 465     SER K   131                                                      
REMARK 465     LYS K   132                                                      
REMARK 465     SER K   133                                                      
REMARK 465     THR K   134                                                      
REMARK 465     SER K   135                                                      
REMARK 465     GLY K   136                                                      
REMARK 465     GLY K   137                                                      
REMARK 465     THR K   138                                                      
REMARK 465     ALA K   139                                                      
REMARK 465     ALA K   140                                                      
REMARK 465     LEU K   141                                                      
REMARK 465     GLY K   142                                                      
REMARK 465     CYS K   143                                                      
REMARK 465     LEU K   144                                                      
REMARK 465     VAL K   145                                                      
REMARK 465     LYS K   146                                                      
REMARK 465     ASP K   147                                                      
REMARK 465     TYR K   148                                                      
REMARK 465     PHE K   149                                                      
REMARK 465     PRO K   150                                                      
REMARK 465     GLU K   151                                                      
REMARK 465     PRO K   152                                                      
REMARK 465     VAL K   153                                                      
REMARK 465     THR K   154                                                      
REMARK 465     VAL K   155                                                      
REMARK 465     SER K   156                                                      
REMARK 465     TRP K   157                                                      
REMARK 465     ASN K   158                                                      
REMARK 465     SER K   159                                                      
REMARK 465     GLY K   160                                                      
REMARK 465     ALA K   161                                                      
REMARK 465     LEU K   162                                                      
REMARK 465     THR K   163                                                      
REMARK 465     SER K   164                                                      
REMARK 465     GLY K   165                                                      
REMARK 465     VAL K   166                                                      
REMARK 465     HIS K   167                                                      
REMARK 465     THR K   168                                                      
REMARK 465     PHE K   169                                                      
REMARK 465     PRO K   170                                                      
REMARK 465     ALA K   171                                                      
REMARK 465     VAL K   172                                                      
REMARK 465     LEU K   173                                                      
REMARK 465     GLN K   174                                                      
REMARK 465     SER K   175                                                      
REMARK 465     SER K   176                                                      
REMARK 465     GLY K   177                                                      
REMARK 465     LEU K   178                                                      
REMARK 465     TYR K   179                                                      
REMARK 465     SER K   180                                                      
REMARK 465     LEU K   181                                                      
REMARK 465     SER K   182                                                      
REMARK 465     SER K   183                                                      
REMARK 465     VAL K   184                                                      
REMARK 465     VAL K   185                                                      
REMARK 465     THR K   186                                                      
REMARK 465     VAL K   187                                                      
REMARK 465     PRO K   188                                                      
REMARK 465     SER K   189                                                      
REMARK 465     SER K   190                                                      
REMARK 465     SER K   191                                                      
REMARK 465     LEU K   192                                                      
REMARK 465     GLY K   193                                                      
REMARK 465     THR K   194                                                      
REMARK 465     GLN K   195                                                      
REMARK 465     THR K   196                                                      
REMARK 465     TYR K   197                                                      
REMARK 465     ILE K   198                                                      
REMARK 465     CYS K   199                                                      
REMARK 465     ASN K   200                                                      
REMARK 465     VAL K   201                                                      
REMARK 465     ASN K   202                                                      
REMARK 465     HIS K   203                                                      
REMARK 465     LYS K   204                                                      
REMARK 465     PRO K   205                                                      
REMARK 465     SER K   206                                                      
REMARK 465     ASN K   207                                                      
REMARK 465     THR K   208                                                      
REMARK 465     LYS K   209                                                      
REMARK 465     VAL K   210                                                      
REMARK 465     ASP K   211                                                      
REMARK 465     LYS K   212                                                      
REMARK 465     LYS K   213                                                      
REMARK 465     VAL K   214                                                      
REMARK 465     GLU K   215                                                      
REMARK 465     PRO K   216                                                      
REMARK 465     LYS K   217                                                      
REMARK 465     SER K   218                                                      
REMARK 465     CYS K   219                                                      
REMARK 465     ASP K   220                                                      
REMARK 465     LYS K   221                                                      
REMARK 465     THR K   222                                                      
REMARK 465     HIS K   223                                                      
REMARK 465     ARG M   114                                                      
REMARK 465     THR M   115                                                      
REMARK 465     VAL M   116                                                      
REMARK 465     ALA M   117                                                      
REMARK 465     ALA M   118                                                      
REMARK 465     PRO M   119                                                      
REMARK 465     SER M   120                                                      
REMARK 465     VAL M   121                                                      
REMARK 465     PHE M   122                                                      
REMARK 465     ILE M   123                                                      
REMARK 465     PHE M   124                                                      
REMARK 465     PRO M   125                                                      
REMARK 465     PRO M   126                                                      
REMARK 465     SER M   127                                                      
REMARK 465     ASP M   128                                                      
REMARK 465     GLU M   129                                                      
REMARK 465     GLN M   130                                                      
REMARK 465     LEU M   131                                                      
REMARK 465     LYS M   132                                                      
REMARK 465     SER M   133                                                      
REMARK 465     GLY M   134                                                      
REMARK 465     THR M   135                                                      
REMARK 465     ALA M   136                                                      
REMARK 465     SER M   137                                                      
REMARK 465     VAL M   138                                                      
REMARK 465     VAL M   139                                                      
REMARK 465     CYS M   140                                                      
REMARK 465     LEU M   141                                                      
REMARK 465     LEU M   142                                                      
REMARK 465     ASN M   143                                                      
REMARK 465     ASN M   144                                                      
REMARK 465     PHE M   145                                                      
REMARK 465     TYR M   146                                                      
REMARK 465     PRO M   147                                                      
REMARK 465     ARG M   148                                                      
REMARK 465     GLU M   149                                                      
REMARK 465     ALA M   150                                                      
REMARK 465     LYS M   151                                                      
REMARK 465     VAL M   152                                                      
REMARK 465     GLN M   153                                                      
REMARK 465     TRP M   154                                                      
REMARK 465     LYS M   155                                                      
REMARK 465     VAL M   156                                                      
REMARK 465     ASP M   157                                                      
REMARK 465     ASN M   158                                                      
REMARK 465     ALA M   159                                                      
REMARK 465     LEU M   160                                                      
REMARK 465     GLN M   161                                                      
REMARK 465     SER M   162                                                      
REMARK 465     GLY M   163                                                      
REMARK 465     ASN M   164                                                      
REMARK 465     SER M   165                                                      
REMARK 465     GLN M   166                                                      
REMARK 465     GLU M   167                                                      
REMARK 465     SER M   168                                                      
REMARK 465     VAL M   169                                                      
REMARK 465     THR M   170                                                      
REMARK 465     GLU M   171                                                      
REMARK 465     GLN M   172                                                      
REMARK 465     ASP M   173                                                      
REMARK 465     SER M   174                                                      
REMARK 465     LYS M   175                                                      
REMARK 465     ASP M   176                                                      
REMARK 465     SER M   177                                                      
REMARK 465     THR M   178                                                      
REMARK 465     TYR M   179                                                      
REMARK 465     SER M   180                                                      
REMARK 465     LEU M   181                                                      
REMARK 465     SER M   182                                                      
REMARK 465     SER M   183                                                      
REMARK 465     THR M   184                                                      
REMARK 465     LEU M   185                                                      
REMARK 465     THR M   186                                                      
REMARK 465     LEU M   187                                                      
REMARK 465     SER M   188                                                      
REMARK 465     LYS M   189                                                      
REMARK 465     ALA M   190                                                      
REMARK 465     ASP M   191                                                      
REMARK 465     TYR M   192                                                      
REMARK 465     GLU M   193                                                      
REMARK 465     LYS M   194                                                      
REMARK 465     HIS M   195                                                      
REMARK 465     LYS M   196                                                      
REMARK 465     VAL M   197                                                      
REMARK 465     TYR M   198                                                      
REMARK 465     ALA M   199                                                      
REMARK 465     CYS M   200                                                      
REMARK 465     GLU M   201                                                      
REMARK 465     VAL M   202                                                      
REMARK 465     THR M   203                                                      
REMARK 465     HIS M   204                                                      
REMARK 465     GLN M   205                                                      
REMARK 465     GLY M   206                                                      
REMARK 465     LEU M   207                                                      
REMARK 465     SER M   208                                                      
REMARK 465     SER M   209                                                      
REMARK 465     PRO M   210                                                      
REMARK 465     VAL M   211                                                      
REMARK 465     THR M   212                                                      
REMARK 465     LYS M   213                                                      
REMARK 465     SER M   214                                                      
REMARK 465     PHE M   215                                                      
REMARK 465     ASN M   216                                                      
REMARK 465     ARG M   217                                                      
REMARK 465     GLY M   218                                                      
REMARK 465     GLU M   219                                                      
REMARK 465     CYS M   220                                                      
REMARK 465     GLU U    21                                                      
REMARK 465     PRO U    22                                                      
REMARK 465     PRO U    23                                                      
REMARK 465     THR U    24                                                      
REMARK 465     ALA U    25                                                      
REMARK 465     PRO U   145                                                      
REMARK 465     CYS U   146                                                      
REMARK 465     PRO U   147                                                      
REMARK 465     VAL U   148                                                      
REMARK 465     GLY U   149                                                      
REMARK 465     PHE U   150                                                      
REMARK 465     PHE U   151                                                      
REMARK 465     SER U   152                                                      
REMARK 465     ASN U   153                                                      
REMARK 465     VAL U   154                                                      
REMARK 465     SER U   155                                                      
REMARK 465     SER U   156                                                      
REMARK 465     ALA U   157                                                      
REMARK 465     PHE U   158                                                      
REMARK 465     GLU U   159                                                      
REMARK 465     LYS U   160                                                      
REMARK 465     CYS U   161                                                      
REMARK 465     HIS U   162                                                      
REMARK 465     PRO U   163                                                      
REMARK 465     TRP U   164                                                      
REMARK 465     THR U   165                                                      
REMARK 465     SER U   166                                                      
REMARK 465     CYS U   167                                                      
REMARK 465     GLU U   168                                                      
REMARK 465     THR U   169                                                      
REMARK 465     LYS U   170                                                      
REMARK 465     ASP U   171                                                      
REMARK 465     LEU U   172                                                      
REMARK 465     VAL U   173                                                      
REMARK 465     VAL U   174                                                      
REMARK 465     GLN U   175                                                      
REMARK 465     GLN U   176                                                      
REMARK 465     ALA U   177                                                      
REMARK 465     GLY U   178                                                      
REMARK 465     THR U   179                                                      
REMARK 465     ASN U   180                                                      
REMARK 465     LYS U   181                                                      
REMARK 465     THR U   182                                                      
REMARK 465     ASP U   183                                                      
REMARK 465     VAL U   184                                                      
REMARK 465     VAL U   185                                                      
REMARK 465     CYS U   186                                                      
REMARK 465     GLY U   187                                                      
REMARK 465     PRO U   188                                                      
REMARK 465     GLN U   189                                                      
REMARK 465     ASP U   190                                                      
REMARK 465     ARG U   191                                                      
REMARK 465     LEU U   192                                                      
REMARK 465     ARG U   193                                                      
REMARK 465     GLU V    21                                                      
REMARK 465     PRO V    22                                                      
REMARK 465     PRO V    23                                                      
REMARK 465     THR V    24                                                      
REMARK 465     ALA V    25                                                      
REMARK 465     CYS V    26                                                      
REMARK 465     ARG V    27                                                      
REMARK 465     GLU V    28                                                      
REMARK 465     LYS V    29                                                      
REMARK 465     GLN V    30                                                      
REMARK 465     TYR V    31                                                      
REMARK 465     LEU V    32                                                      
REMARK 465     ILE V    33                                                      
REMARK 465     ASN V    34                                                      
REMARK 465     SER V    35                                                      
REMARK 465     GLN V    36                                                      
REMARK 465     CYS V    37                                                      
REMARK 465     CYS V    38                                                      
REMARK 465     SER V    39                                                      
REMARK 465     LEU V    40                                                      
REMARK 465     GLU V    53                                                      
REMARK 465     PHE V    54                                                      
REMARK 465     THR V    55                                                      
REMARK 465     HIS V   122                                                      
REMARK 465     ARG V   123                                                      
REMARK 465     SER V   124                                                      
REMARK 465     CYS V   125                                                      
REMARK 465     SER V   126                                                      
REMARK 465     PRO V   127                                                      
REMARK 465     GLY V   128                                                      
REMARK 465     PHE V   129                                                      
REMARK 465     GLY V   130                                                      
REMARK 465     VAL V   131                                                      
REMARK 465     LYS V   132                                                      
REMARK 465     GLN V   133                                                      
REMARK 465     ILE V   134                                                      
REMARK 465     ALA V   135                                                      
REMARK 465     THR V   136                                                      
REMARK 465     GLY V   137                                                      
REMARK 465     VAL V   138                                                      
REMARK 465     SER V   139                                                      
REMARK 465     ASP V   140                                                      
REMARK 465     THR V   141                                                      
REMARK 465     ILE V   142                                                      
REMARK 465     CYS V   143                                                      
REMARK 465     GLU V   144                                                      
REMARK 465     PRO V   145                                                      
REMARK 465     CYS V   146                                                      
REMARK 465     PRO V   147                                                      
REMARK 465     VAL V   148                                                      
REMARK 465     GLY V   149                                                      
REMARK 465     PHE V   150                                                      
REMARK 465     PHE V   151                                                      
REMARK 465     SER V   152                                                      
REMARK 465     ASN V   153                                                      
REMARK 465     VAL V   154                                                      
REMARK 465     SER V   155                                                      
REMARK 465     SER V   156                                                      
REMARK 465     ALA V   157                                                      
REMARK 465     PHE V   158                                                      
REMARK 465     GLU V   159                                                      
REMARK 465     LYS V   160                                                      
REMARK 465     CYS V   161                                                      
REMARK 465     HIS V   162                                                      
REMARK 465     PRO V   163                                                      
REMARK 465     TRP V   164                                                      
REMARK 465     THR V   165                                                      
REMARK 465     SER V   166                                                      
REMARK 465     CYS V   167                                                      
REMARK 465     GLU V   168                                                      
REMARK 465     THR V   169                                                      
REMARK 465     LYS V   170                                                      
REMARK 465     ASP V   171                                                      
REMARK 465     LEU V   172                                                      
REMARK 465     VAL V   173                                                      
REMARK 465     VAL V   174                                                      
REMARK 465     GLN V   175                                                      
REMARK 465     GLN V   176                                                      
REMARK 465     ALA V   177                                                      
REMARK 465     GLY V   178                                                      
REMARK 465     THR V   179                                                      
REMARK 465     ASN V   180                                                      
REMARK 465     LYS V   181                                                      
REMARK 465     THR V   182                                                      
REMARK 465     ASP V   183                                                      
REMARK 465     VAL V   184                                                      
REMARK 465     VAL V   185                                                      
REMARK 465     CYS V   186                                                      
REMARK 465     GLY V   187                                                      
REMARK 465     PRO V   188                                                      
REMARK 465     GLN V   189                                                      
REMARK 465     ASP V   190                                                      
REMARK 465     ARG V   191                                                      
REMARK 465     LEU V   192                                                      
REMARK 465     ARG V   193                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     ARG A  55    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS B  24    CG   CD   CE   NZ                                   
REMARK 470     LYS B  45    CG   CD   CE   NZ                                   
REMARK 470     ARG C  55    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS C  76    CG   CD   CE   NZ                                   
REMARK 470     LYS C 213    CG   CD   CE   NZ                                   
REMARK 470     LYS C 217    CG   CD   CE   NZ                                   
REMARK 470     CYS C 219    SG                                                  
REMARK 470     ARG D  18    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS D  45    CG   CD   CE   NZ                                   
REMARK 470     LYS D 132    CG   CD   CE   NZ                                   
REMARK 470     LYS E 120    CG   CD   CE   NZ                                   
REMARK 470     LYS E 204    CG   CD   CE   NZ                                   
REMARK 470     ARG F  18    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS F  24    CG   CD   CE   NZ                                   
REMARK 470     GLN F  85    CG   CD   OE1  NE2                                  
REMARK 470     LYS F 109    CG   CD   CE   NZ                                   
REMARK 470     LYS F 175    CG   CD   CE   NZ                                   
REMARK 470     ARG G  27    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLN G  30    CG   CD   OE1  NE2                                  
REMARK 470     LEU G  32    CG   CD1  CD2                                       
REMARK 470     ILE G  33    CG1  CG2  CD1                                       
REMARK 470     PHE G  54    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     GLU G  56    CG   CD   OE1  OE2                                  
REMARK 470     LEU G  60    CG   CD1  CD2                                       
REMARK 470     ARG G  90    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU G 106    CG   CD   OE1  OE2                                  
REMARK 470     ARG G 123    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS G 132    CG   CD   CE   NZ                                   
REMARK 470     GLN G 133    CG   CD   OE1  NE2                                  
REMARK 470     GLU G 144    CG   CD   OE1  OE2                                  
REMARK 470     CYS G 146    SG                                                  
REMARK 470     ARG H  55    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS H 217    CG   CD   CE   NZ                                   
REMARK 470     ARG I  27    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG I  90    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU I 106    CG   CD   OE1  OE2                                  
REMARK 470     GLU I 114    CG   CD   OE1  OE2                                  
REMARK 470     ARG J  27    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS J  29    CG   CD   CE   NZ                                   
REMARK 470     LEU J  32    CG   CD1  CD2                                       
REMARK 470     ILE J  33    CG1  CG2  CD1                                       
REMARK 470     LYS J  46    CG   CD   CE   NZ                                   
REMARK 470     LEU J  47    CG   CD1  CD2                                       
REMARK 470     GLU J  58    CG   CD   OE1  OE2                                  
REMARK 470     GLN J  79    CG   CD   OE1  NE2                                  
REMARK 470     ARG J  90    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS J  94    CG   CD   CE   NZ                                   
REMARK 470     LEU K  11    CG   CD1  CD2                                       
REMARK 470     LYS K  13    CG   CD   CE   NZ                                   
REMARK 470     ARG K  19    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     TYR K  32    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     TYR K  50    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     ARG K  72    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS K  76    CG   CD   CE   NZ                                   
REMARK 470     GLN K 108    CG   CD   OE1  NE2                                  
REMARK 470     LYS L 132    CG   CD   CE   NZ                                   
REMARK 470     ARG M  60    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG U  27    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LEU U 121    CG   CD1  CD2                                       
REMARK 470     ARG U 123    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS U 132    CG   CD   CE   NZ                                   
REMARK 470     GLN U 133    CG   CD   OE1  NE2                                  
REMARK 470     GLU U 144    CG   CD   OE1  OE2                                  
REMARK 470     GLN V  42    CG   CD   OE1  NE2                                  
REMARK 470     ARG V  73    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU V 107    CG   CD   OE1  OE2                                  
REMARK 470     HIS V 110    CG   ND1  CD2  CE1  NE2                             
REMARK 470     GLU V 114    CG   CD   OE1  OE2                                  
REMARK 470     VAL V 120    CG1  CG2                                            
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   NH2  ARG B   114     OG1  THR H   208              2.11            
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS                                      
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,2(A3,1X,A1,I4,A1,1X,A4,3X),1X,F6.3)               
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   RES CSSEQI ATM2   DEVIATION                     
REMARK 500    CYS I  83   CA    CYS I  83   CB     -0.085                       
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500    PRO C 152   C   -  N   -  CD  ANGL. DEV. =  14.1 DEGREES          
REMARK 500    CYS I 103   CA  -  CB  -  SG  ANGL. DEV. = -12.6 DEGREES          
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    ARG A  55       42.36    -79.88                                   
REMARK 500    SER A  56       55.27     32.64                                   
REMARK 500    TYR A 102      148.40   -174.77                                   
REMARK 500    ASP A 147       75.92     60.03                                   
REMARK 500    SER A 175      -37.82    -37.59                                   
REMARK 500    SER A 176        3.95    -69.95                                   
REMARK 500    ALA B  57      -22.84     72.80                                   
REMARK 500    SER B  58      -20.73   -140.29                                   
REMARK 500    LYS B 132       -4.35    -57.28                                   
REMARK 500    ASN B 144       74.74     62.61                                   
REMARK 500    LEU C  18      141.28   -172.84                                   
REMARK 500    ARG C  67      -31.88   -133.16                                   
REMARK 500    ALA C  92     -169.75   -167.39                                   
REMARK 500    ASP C 147       70.50     59.03                                   
REMARK 500    PHE C 149      138.83   -172.79                                   
REMARK 500    PRO C 152      -96.36   -105.40                                   
REMARK 500    VAL C 153      137.49    168.55                                   
REMARK 500    SER C 176       -9.09    -59.35                                   
REMARK 500    TYR D  38       77.80   -100.31                                   
REMARK 500    ALA D  57      -17.40     73.76                                   
REMARK 500    SER D  73      147.74   -171.77                                   
REMARK 500    ALA D  90     -172.14   -173.11                                   
REMARK 500    LYS D 132       46.45    -79.62                                   
REMARK 500    ASN D 158       16.42     54.55                                   
REMARK 500    LYS D 175      -62.03    -95.01                                   
REMARK 500    PHE E 149      136.11   -170.19                                   
REMARK 500    SER E 159       17.32     51.37                                   
REMARK 500    ASN E 207       63.20     60.14                                   
REMARK 500    ALA F  57      -18.82     72.33                                   
REMARK 500    SER F  58      -12.94   -142.03                                   
REMARK 500    PRO F  65      161.07    -49.20                                   
REMARK 500    SER F 182       48.05   -141.80                                   
REMARK 500    SER G  35       14.70     57.78                                   
REMARK 500    VAL G  48      -61.17    -99.01                                   
REMARK 500    ASP G  50     -166.13    -74.64                                   
REMARK 500    SER G 139       97.33   -167.48                                   
REMARK 500    GLU H  89        6.13    -67.64                                   
REMARK 500    ASP H 147       71.85     60.58                                   
REMARK 500    ASP J  50     -169.76    -77.87                                   
REMARK 500    ASN J  86        3.59    -65.38                                   
REMARK 500    THR J  96     -169.46   -118.99                                   
REMARK 500    THR J 104     -168.55   -129.16                                   
REMARK 500    ARG K  55        1.48    -65.36                                   
REMARK 500    SER K  85       52.79     33.99                                   
REMARK 500    SER K 115     -165.21    -78.52                                   
REMARK 500    ALA L  57      -22.14     65.78                                   
REMARK 500    SER L  58      -21.90   -143.78                                   
REMARK 500    ASN L 144       70.58     46.87                                   
REMARK 500    LEU M  53      -60.93    -94.79                                   
REMARK 500    TRP M  56       15.26     59.72                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS      66 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 800                                                                      
REMARK 800 SITE                                                                 
REMARK 800 SITE_IDENTIFIER: AC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue SO4 A 301                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue SO4 H 301                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue SO4 H 302                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue SO4 I 201                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue SO4 L 401                 
DBREF  6PE9 A    1   223  PDB    6PE9     6PE9             1    223             
DBREF  6PE9 B    1   220  PDB    6PE9     6PE9             1    220             
DBREF  6PE9 C    1   223  PDB    6PE9     6PE9             1    223             
DBREF  6PE9 D    1   220  PDB    6PE9     6PE9             1    220             
DBREF  6PE9 E    1   223  PDB    6PE9     6PE9             1    223             
DBREF  6PE9 F    1   220  PDB    6PE9     6PE9             1    220             
DBREF  6PE9 G   21   193  UNP    P25942   TNR5_HUMAN      21    193             
DBREF  6PE9 H    1   223  PDB    6PE9     6PE9             1    223             
DBREF  6PE9 I   21   193  UNP    P25942   TNR5_HUMAN      21    193             
DBREF  6PE9 J   21   193  UNP    P25942   TNR5_HUMAN      21    193             
DBREF  6PE9 K    1   223  PDB    6PE9     6PE9             1    223             
DBREF  6PE9 L    1   220  PDB    6PE9     6PE9             1    220             
DBREF  6PE9 M    1   220  PDB    6PE9     6PE9             1    220             
DBREF  6PE9 U   21   193  UNP    P25942   TNR5_HUMAN      21    193             
DBREF  6PE9 V   21   193  UNP    P25942   TNR5_HUMAN      21    193             
SEQRES   1 A  223  GLU VAL GLN LEU VAL GLU SER GLY GLY GLY LEU VAL LYS          
SEQRES   2 A  223  PRO GLY GLY SER LEU ARG LEU SER CYS ALA ALA SER GLY          
SEQRES   3 A  223  PHE THR PHE SER ASP TYR GLY MET ASN TRP VAL ARG GLN          
SEQRES   4 A  223  ALA PRO GLY LYS GLY LEU GLU TRP VAL SER TYR ILE SER          
SEQRES   5 A  223  SER GLY ARG SER ASN ILE TYR TYR ALA ASP THR VAL LYS          
SEQRES   6 A  223  GLY ARG PHE THR ILE SER ARG ASP ASN ALA LYS ASN SER          
SEQRES   7 A  223  LEU TYR LEU GLN MET ASN SER LEU ARG ALA GLU ASP THR          
SEQRES   8 A  223  ALA VAL TYR TYR CYS ALA ARG SER TRP GLY TYR PHE ASP          
SEQRES   9 A  223  VAL TRP GLY GLN GLY THR THR VAL THR VAL SER SER ALA          
SEQRES  10 A  223  SER THR LYS GLY PRO SER VAL PHE PRO LEU ALA PRO SER          
SEQRES  11 A  223  SER LYS SER THR SER GLY GLY THR ALA ALA LEU GLY CYS          
SEQRES  12 A  223  LEU VAL LYS ASP TYR PHE PRO GLU PRO VAL THR VAL SER          
SEQRES  13 A  223  TRP ASN SER GLY ALA LEU THR SER GLY VAL HIS THR PHE          
SEQRES  14 A  223  PRO ALA VAL LEU GLN SER SER GLY LEU TYR SER LEU SER          
SEQRES  15 A  223  SER VAL VAL THR VAL PRO SER SER SER LEU GLY THR GLN          
SEQRES  16 A  223  THR TYR ILE CYS ASN VAL ASN HIS LYS PRO SER ASN THR          
SEQRES  17 A  223  LYS VAL ASP LYS LYS VAL GLU PRO LYS SER CYS ASP LYS          
SEQRES  18 A  223  THR HIS                                                      
SEQRES   1 B  220  ASP ILE VAL MET THR GLN SER PRO ASP SER LEU ALA VAL          
SEQRES   2 B  220  SER LEU GLY GLU ARG ALA THR ILE ASN CYS LYS SER SER          
SEQRES   3 B  220  GLN SER LEU LEU ASN LEU GLY ASN GLN LYS ASN TYR LEU          
SEQRES   4 B  220  THR TRP PHE GLN GLN LYS PRO GLY GLN PRO PRO LYS LEU          
SEQRES   5 B  220  LEU ILE TYR TRP ALA SER THR ARG GLU SER GLY VAL PRO          
SEQRES   6 B  220  ASP ARG PHE SER GLY SER GLY SER GLY THR ASP PHE THR          
SEQRES   7 B  220  LEU THR ILE SER SER LEU GLN ALA GLU ASP VAL ALA VAL          
SEQRES   8 B  220  TYR TYR CYS GLN ASN ASP TYR THR TYR PRO LEU THR PHE          
SEQRES   9 B  220  GLY GLN GLY THR LYS LEU GLU ILE LYS ARG THR VAL ALA          
SEQRES  10 B  220  ALA PRO SER VAL PHE ILE PHE PRO PRO SER ASP GLU GLN          
SEQRES  11 B  220  LEU LYS SER GLY THR ALA SER VAL VAL CYS LEU LEU ASN          
SEQRES  12 B  220  ASN PHE TYR PRO ARG GLU ALA LYS VAL GLN TRP LYS VAL          
SEQRES  13 B  220  ASP ASN ALA LEU GLN SER GLY ASN SER GLN GLU SER VAL          
SEQRES  14 B  220  THR GLU GLN ASP SER LYS ASP SER THR TYR SER LEU SER          
SEQRES  15 B  220  SER THR LEU THR LEU SER LYS ALA ASP TYR GLU LYS HIS          
SEQRES  16 B  220  LYS VAL TYR ALA CYS GLU VAL THR HIS GLN GLY LEU SER          
SEQRES  17 B  220  SER PRO VAL THR LYS SER PHE ASN ARG GLY GLU CYS              
SEQRES   1 C  223  GLU VAL GLN LEU VAL GLU SER GLY GLY GLY LEU VAL LYS          
SEQRES   2 C  223  PRO GLY GLY SER LEU ARG LEU SER CYS ALA ALA SER GLY          
SEQRES   3 C  223  PHE THR PHE SER ASP TYR GLY MET ASN TRP VAL ARG GLN          
SEQRES   4 C  223  ALA PRO GLY LYS GLY LEU GLU TRP VAL SER TYR ILE SER          
SEQRES   5 C  223  SER GLY ARG SER ASN ILE TYR TYR ALA ASP THR VAL LYS          
SEQRES   6 C  223  GLY ARG PHE THR ILE SER ARG ASP ASN ALA LYS ASN SER          
SEQRES   7 C  223  LEU TYR LEU GLN MET ASN SER LEU ARG ALA GLU ASP THR          
SEQRES   8 C  223  ALA VAL TYR TYR CYS ALA ARG SER TRP GLY TYR PHE ASP          
SEQRES   9 C  223  VAL TRP GLY GLN GLY THR THR VAL THR VAL SER SER ALA          
SEQRES  10 C  223  SER THR LYS GLY PRO SER VAL PHE PRO LEU ALA PRO SER          
SEQRES  11 C  223  SER LYS SER THR SER GLY GLY THR ALA ALA LEU GLY CYS          
SEQRES  12 C  223  LEU VAL LYS ASP TYR PHE PRO GLU PRO VAL THR VAL SER          
SEQRES  13 C  223  TRP ASN SER GLY ALA LEU THR SER GLY VAL HIS THR PHE          
SEQRES  14 C  223  PRO ALA VAL LEU GLN SER SER GLY LEU TYR SER LEU SER          
SEQRES  15 C  223  SER VAL VAL THR VAL PRO SER SER SER LEU GLY THR GLN          
SEQRES  16 C  223  THR TYR ILE CYS ASN VAL ASN HIS LYS PRO SER ASN THR          
SEQRES  17 C  223  LYS VAL ASP LYS LYS VAL GLU PRO LYS SER CYS ASP LYS          
SEQRES  18 C  223  THR HIS                                                      
SEQRES   1 D  220  ASP ILE VAL MET THR GLN SER PRO ASP SER LEU ALA VAL          
SEQRES   2 D  220  SER LEU GLY GLU ARG ALA THR ILE ASN CYS LYS SER SER          
SEQRES   3 D  220  GLN SER LEU LEU ASN LEU GLY ASN GLN LYS ASN TYR LEU          
SEQRES   4 D  220  THR TRP PHE GLN GLN LYS PRO GLY GLN PRO PRO LYS LEU          
SEQRES   5 D  220  LEU ILE TYR TRP ALA SER THR ARG GLU SER GLY VAL PRO          
SEQRES   6 D  220  ASP ARG PHE SER GLY SER GLY SER GLY THR ASP PHE THR          
SEQRES   7 D  220  LEU THR ILE SER SER LEU GLN ALA GLU ASP VAL ALA VAL          
SEQRES   8 D  220  TYR TYR CYS GLN ASN ASP TYR THR TYR PRO LEU THR PHE          
SEQRES   9 D  220  GLY GLN GLY THR LYS LEU GLU ILE LYS ARG THR VAL ALA          
SEQRES  10 D  220  ALA PRO SER VAL PHE ILE PHE PRO PRO SER ASP GLU GLN          
SEQRES  11 D  220  LEU LYS SER GLY THR ALA SER VAL VAL CYS LEU LEU ASN          
SEQRES  12 D  220  ASN PHE TYR PRO ARG GLU ALA LYS VAL GLN TRP LYS VAL          
SEQRES  13 D  220  ASP ASN ALA LEU GLN SER GLY ASN SER GLN GLU SER VAL          
SEQRES  14 D  220  THR GLU GLN ASP SER LYS ASP SER THR TYR SER LEU SER          
SEQRES  15 D  220  SER THR LEU THR LEU SER LYS ALA ASP TYR GLU LYS HIS          
SEQRES  16 D  220  LYS VAL TYR ALA CYS GLU VAL THR HIS GLN GLY LEU SER          
SEQRES  17 D  220  SER PRO VAL THR LYS SER PHE ASN ARG GLY GLU CYS              
SEQRES   1 E  223  GLU VAL GLN LEU VAL GLU SER GLY GLY GLY LEU VAL LYS          
SEQRES   2 E  223  PRO GLY GLY SER LEU ARG LEU SER CYS ALA ALA SER GLY          
SEQRES   3 E  223  PHE THR PHE SER ASP TYR GLY MET ASN TRP VAL ARG GLN          
SEQRES   4 E  223  ALA PRO GLY LYS GLY LEU GLU TRP VAL SER TYR ILE SER          
SEQRES   5 E  223  SER GLY ARG SER ASN ILE TYR TYR ALA ASP THR VAL LYS          
SEQRES   6 E  223  GLY ARG PHE THR ILE SER ARG ASP ASN ALA LYS ASN SER          
SEQRES   7 E  223  LEU TYR LEU GLN MET ASN SER LEU ARG ALA GLU ASP THR          
SEQRES   8 E  223  ALA VAL TYR TYR CYS ALA ARG SER TRP GLY TYR PHE ASP          
SEQRES   9 E  223  VAL TRP GLY GLN GLY THR THR VAL THR VAL SER SER ALA          
SEQRES  10 E  223  SER THR LYS GLY PRO SER VAL PHE PRO LEU ALA PRO SER          
SEQRES  11 E  223  SER LYS SER THR SER GLY GLY THR ALA ALA LEU GLY CYS          
SEQRES  12 E  223  LEU VAL LYS ASP TYR PHE PRO GLU PRO VAL THR VAL SER          
SEQRES  13 E  223  TRP ASN SER GLY ALA LEU THR SER GLY VAL HIS THR PHE          
SEQRES  14 E  223  PRO ALA VAL LEU GLN SER SER GLY LEU TYR SER LEU SER          
SEQRES  15 E  223  SER VAL VAL THR VAL PRO SER SER SER LEU GLY THR GLN          
SEQRES  16 E  223  THR TYR ILE CYS ASN VAL ASN HIS LYS PRO SER ASN THR          
SEQRES  17 E  223  LYS VAL ASP LYS LYS VAL GLU PRO LYS SER CYS ASP LYS          
SEQRES  18 E  223  THR HIS                                                      
SEQRES   1 F  220  ASP ILE VAL MET THR GLN SER PRO ASP SER LEU ALA VAL          
SEQRES   2 F  220  SER LEU GLY GLU ARG ALA THR ILE ASN CYS LYS SER SER          
SEQRES   3 F  220  GLN SER LEU LEU ASN LEU GLY ASN GLN LYS ASN TYR LEU          
SEQRES   4 F  220  THR TRP PHE GLN GLN LYS PRO GLY GLN PRO PRO LYS LEU          
SEQRES   5 F  220  LEU ILE TYR TRP ALA SER THR ARG GLU SER GLY VAL PRO          
SEQRES   6 F  220  ASP ARG PHE SER GLY SER GLY SER GLY THR ASP PHE THR          
SEQRES   7 F  220  LEU THR ILE SER SER LEU GLN ALA GLU ASP VAL ALA VAL          
SEQRES   8 F  220  TYR TYR CYS GLN ASN ASP TYR THR TYR PRO LEU THR PHE          
SEQRES   9 F  220  GLY GLN GLY THR LYS LEU GLU ILE LYS ARG THR VAL ALA          
SEQRES  10 F  220  ALA PRO SER VAL PHE ILE PHE PRO PRO SER ASP GLU GLN          
SEQRES  11 F  220  LEU LYS SER GLY THR ALA SER VAL VAL CYS LEU LEU ASN          
SEQRES  12 F  220  ASN PHE TYR PRO ARG GLU ALA LYS VAL GLN TRP LYS VAL          
SEQRES  13 F  220  ASP ASN ALA LEU GLN SER GLY ASN SER GLN GLU SER VAL          
SEQRES  14 F  220  THR GLU GLN ASP SER LYS ASP SER THR TYR SER LEU SER          
SEQRES  15 F  220  SER THR LEU THR LEU SER LYS ALA ASP TYR GLU LYS HIS          
SEQRES  16 F  220  LYS VAL TYR ALA CYS GLU VAL THR HIS GLN GLY LEU SER          
SEQRES  17 F  220  SER PRO VAL THR LYS SER PHE ASN ARG GLY GLU CYS              
SEQRES   1 G  173  GLU PRO PRO THR ALA CYS ARG GLU LYS GLN TYR LEU ILE          
SEQRES   2 G  173  ASN SER GLN CYS CYS SER LEU CYS GLN PRO GLY GLN LYS          
SEQRES   3 G  173  LEU VAL SER ASP CYS THR GLU PHE THR GLU THR GLU CYS          
SEQRES   4 G  173  LEU PRO CYS GLY GLU SER GLU PHE LEU ASP THR TRP ASN          
SEQRES   5 G  173  ARG GLU THR HIS CYS HIS GLN HIS LYS TYR CYS ASP PRO          
SEQRES   6 G  173  ASN LEU GLY LEU ARG VAL GLN GLN LYS GLY THR SER GLU          
SEQRES   7 G  173  THR ASP THR ILE CYS THR CYS GLU GLU GLY TRP HIS CYS          
SEQRES   8 G  173  THR SER GLU ALA CYS GLU SER CYS VAL LEU HIS ARG SER          
SEQRES   9 G  173  CYS SER PRO GLY PHE GLY VAL LYS GLN ILE ALA THR GLY          
SEQRES  10 G  173  VAL SER ASP THR ILE CYS GLU PRO CYS PRO VAL GLY PHE          
SEQRES  11 G  173  PHE SER ASN VAL SER SER ALA PHE GLU LYS CYS HIS PRO          
SEQRES  12 G  173  TRP THR SER CYS GLU THR LYS ASP LEU VAL VAL GLN GLN          
SEQRES  13 G  173  ALA GLY THR ASN LYS THR ASP VAL VAL CYS GLY PRO GLN          
SEQRES  14 G  173  ASP ARG LEU ARG                                              
SEQRES   1 H  223  GLU VAL GLN LEU VAL GLU SER GLY GLY GLY LEU VAL LYS          
SEQRES   2 H  223  PRO GLY GLY SER LEU ARG LEU SER CYS ALA ALA SER GLY          
SEQRES   3 H  223  PHE THR PHE SER ASP TYR GLY MET ASN TRP VAL ARG GLN          
SEQRES   4 H  223  ALA PRO GLY LYS GLY LEU GLU TRP VAL SER TYR ILE SER          
SEQRES   5 H  223  SER GLY ARG SER ASN ILE TYR TYR ALA ASP THR VAL LYS          
SEQRES   6 H  223  GLY ARG PHE THR ILE SER ARG ASP ASN ALA LYS ASN SER          
SEQRES   7 H  223  LEU TYR LEU GLN MET ASN SER LEU ARG ALA GLU ASP THR          
SEQRES   8 H  223  ALA VAL TYR TYR CYS ALA ARG SER TRP GLY TYR PHE ASP          
SEQRES   9 H  223  VAL TRP GLY GLN GLY THR THR VAL THR VAL SER SER ALA          
SEQRES  10 H  223  SER THR LYS GLY PRO SER VAL PHE PRO LEU ALA PRO SER          
SEQRES  11 H  223  SER LYS SER THR SER GLY GLY THR ALA ALA LEU GLY CYS          
SEQRES  12 H  223  LEU VAL LYS ASP TYR PHE PRO GLU PRO VAL THR VAL SER          
SEQRES  13 H  223  TRP ASN SER GLY ALA LEU THR SER GLY VAL HIS THR PHE          
SEQRES  14 H  223  PRO ALA VAL LEU GLN SER SER GLY LEU TYR SER LEU SER          
SEQRES  15 H  223  SER VAL VAL THR VAL PRO SER SER SER LEU GLY THR GLN          
SEQRES  16 H  223  THR TYR ILE CYS ASN VAL ASN HIS LYS PRO SER ASN THR          
SEQRES  17 H  223  LYS VAL ASP LYS LYS VAL GLU PRO LYS SER CYS ASP LYS          
SEQRES  18 H  223  THR HIS                                                      
SEQRES   1 I  173  GLU PRO PRO THR ALA CYS ARG GLU LYS GLN TYR LEU ILE          
SEQRES   2 I  173  ASN SER GLN CYS CYS SER LEU CYS GLN PRO GLY GLN LYS          
SEQRES   3 I  173  LEU VAL SER ASP CYS THR GLU PHE THR GLU THR GLU CYS          
SEQRES   4 I  173  LEU PRO CYS GLY GLU SER GLU PHE LEU ASP THR TRP ASN          
SEQRES   5 I  173  ARG GLU THR HIS CYS HIS GLN HIS LYS TYR CYS ASP PRO          
SEQRES   6 I  173  ASN LEU GLY LEU ARG VAL GLN GLN LYS GLY THR SER GLU          
SEQRES   7 I  173  THR ASP THR ILE CYS THR CYS GLU GLU GLY TRP HIS CYS          
SEQRES   8 I  173  THR SER GLU ALA CYS GLU SER CYS VAL LEU HIS ARG SER          
SEQRES   9 I  173  CYS SER PRO GLY PHE GLY VAL LYS GLN ILE ALA THR GLY          
SEQRES  10 I  173  VAL SER ASP THR ILE CYS GLU PRO CYS PRO VAL GLY PHE          
SEQRES  11 I  173  PHE SER ASN VAL SER SER ALA PHE GLU LYS CYS HIS PRO          
SEQRES  12 I  173  TRP THR SER CYS GLU THR LYS ASP LEU VAL VAL GLN GLN          
SEQRES  13 I  173  ALA GLY THR ASN LYS THR ASP VAL VAL CYS GLY PRO GLN          
SEQRES  14 I  173  ASP ARG LEU ARG                                              
SEQRES   1 J  173  GLU PRO PRO THR ALA CYS ARG GLU LYS GLN TYR LEU ILE          
SEQRES   2 J  173  ASN SER GLN CYS CYS SER LEU CYS GLN PRO GLY GLN LYS          
SEQRES   3 J  173  LEU VAL SER ASP CYS THR GLU PHE THR GLU THR GLU CYS          
SEQRES   4 J  173  LEU PRO CYS GLY GLU SER GLU PHE LEU ASP THR TRP ASN          
SEQRES   5 J  173  ARG GLU THR HIS CYS HIS GLN HIS LYS TYR CYS ASP PRO          
SEQRES   6 J  173  ASN LEU GLY LEU ARG VAL GLN GLN LYS GLY THR SER GLU          
SEQRES   7 J  173  THR ASP THR ILE CYS THR CYS GLU GLU GLY TRP HIS CYS          
SEQRES   8 J  173  THR SER GLU ALA CYS GLU SER CYS VAL LEU HIS ARG SER          
SEQRES   9 J  173  CYS SER PRO GLY PHE GLY VAL LYS GLN ILE ALA THR GLY          
SEQRES  10 J  173  VAL SER ASP THR ILE CYS GLU PRO CYS PRO VAL GLY PHE          
SEQRES  11 J  173  PHE SER ASN VAL SER SER ALA PHE GLU LYS CYS HIS PRO          
SEQRES  12 J  173  TRP THR SER CYS GLU THR LYS ASP LEU VAL VAL GLN GLN          
SEQRES  13 J  173  ALA GLY THR ASN LYS THR ASP VAL VAL CYS GLY PRO GLN          
SEQRES  14 J  173  ASP ARG LEU ARG                                              
SEQRES   1 K  223  GLU VAL GLN LEU VAL GLU SER GLY GLY GLY LEU VAL LYS          
SEQRES   2 K  223  PRO GLY GLY SER LEU ARG LEU SER CYS ALA ALA SER GLY          
SEQRES   3 K  223  PHE THR PHE SER ASP TYR GLY MET ASN TRP VAL ARG GLN          
SEQRES   4 K  223  ALA PRO GLY LYS GLY LEU GLU TRP VAL SER TYR ILE SER          
SEQRES   5 K  223  SER GLY ARG SER ASN ILE TYR TYR ALA ASP THR VAL LYS          
SEQRES   6 K  223  GLY ARG PHE THR ILE SER ARG ASP ASN ALA LYS ASN SER          
SEQRES   7 K  223  LEU TYR LEU GLN MET ASN SER LEU ARG ALA GLU ASP THR          
SEQRES   8 K  223  ALA VAL TYR TYR CYS ALA ARG SER TRP GLY TYR PHE ASP          
SEQRES   9 K  223  VAL TRP GLY GLN GLY THR THR VAL THR VAL SER SER ALA          
SEQRES  10 K  223  SER THR LYS GLY PRO SER VAL PHE PRO LEU ALA PRO SER          
SEQRES  11 K  223  SER LYS SER THR SER GLY GLY THR ALA ALA LEU GLY CYS          
SEQRES  12 K  223  LEU VAL LYS ASP TYR PHE PRO GLU PRO VAL THR VAL SER          
SEQRES  13 K  223  TRP ASN SER GLY ALA LEU THR SER GLY VAL HIS THR PHE          
SEQRES  14 K  223  PRO ALA VAL LEU GLN SER SER GLY LEU TYR SER LEU SER          
SEQRES  15 K  223  SER VAL VAL THR VAL PRO SER SER SER LEU GLY THR GLN          
SEQRES  16 K  223  THR TYR ILE CYS ASN VAL ASN HIS LYS PRO SER ASN THR          
SEQRES  17 K  223  LYS VAL ASP LYS LYS VAL GLU PRO LYS SER CYS ASP LYS          
SEQRES  18 K  223  THR HIS                                                      
SEQRES   1 L  220  ASP ILE VAL MET THR GLN SER PRO ASP SER LEU ALA VAL          
SEQRES   2 L  220  SER LEU GLY GLU ARG ALA THR ILE ASN CYS LYS SER SER          
SEQRES   3 L  220  GLN SER LEU LEU ASN LEU GLY ASN GLN LYS ASN TYR LEU          
SEQRES   4 L  220  THR TRP PHE GLN GLN LYS PRO GLY GLN PRO PRO LYS LEU          
SEQRES   5 L  220  LEU ILE TYR TRP ALA SER THR ARG GLU SER GLY VAL PRO          
SEQRES   6 L  220  ASP ARG PHE SER GLY SER GLY SER GLY THR ASP PHE THR          
SEQRES   7 L  220  LEU THR ILE SER SER LEU GLN ALA GLU ASP VAL ALA VAL          
SEQRES   8 L  220  TYR TYR CYS GLN ASN ASP TYR THR TYR PRO LEU THR PHE          
SEQRES   9 L  220  GLY GLN GLY THR LYS LEU GLU ILE LYS ARG THR VAL ALA          
SEQRES  10 L  220  ALA PRO SER VAL PHE ILE PHE PRO PRO SER ASP GLU GLN          
SEQRES  11 L  220  LEU LYS SER GLY THR ALA SER VAL VAL CYS LEU LEU ASN          
SEQRES  12 L  220  ASN PHE TYR PRO ARG GLU ALA LYS VAL GLN TRP LYS VAL          
SEQRES  13 L  220  ASP ASN ALA LEU GLN SER GLY ASN SER GLN GLU SER VAL          
SEQRES  14 L  220  THR GLU GLN ASP SER LYS ASP SER THR TYR SER LEU SER          
SEQRES  15 L  220  SER THR LEU THR LEU SER LYS ALA ASP TYR GLU LYS HIS          
SEQRES  16 L  220  LYS VAL TYR ALA CYS GLU VAL THR HIS GLN GLY LEU SER          
SEQRES  17 L  220  SER PRO VAL THR LYS SER PHE ASN ARG GLY GLU CYS              
SEQRES   1 M  220  ASP ILE VAL MET THR GLN SER PRO ASP SER LEU ALA VAL          
SEQRES   2 M  220  SER LEU GLY GLU ARG ALA THR ILE ASN CYS LYS SER SER          
SEQRES   3 M  220  GLN SER LEU LEU ASN LEU GLY ASN GLN LYS ASN TYR LEU          
SEQRES   4 M  220  THR TRP PHE GLN GLN LYS PRO GLY GLN PRO PRO LYS LEU          
SEQRES   5 M  220  LEU ILE TYR TRP ALA SER THR ARG GLU SER GLY VAL PRO          
SEQRES   6 M  220  ASP ARG PHE SER GLY SER GLY SER GLY THR ASP PHE THR          
SEQRES   7 M  220  LEU THR ILE SER SER LEU GLN ALA GLU ASP VAL ALA VAL          
SEQRES   8 M  220  TYR TYR CYS GLN ASN ASP TYR THR TYR PRO LEU THR PHE          
SEQRES   9 M  220  GLY GLN GLY THR LYS LEU GLU ILE LYS ARG THR VAL ALA          
SEQRES  10 M  220  ALA PRO SER VAL PHE ILE PHE PRO PRO SER ASP GLU GLN          
SEQRES  11 M  220  LEU LYS SER GLY THR ALA SER VAL VAL CYS LEU LEU ASN          
SEQRES  12 M  220  ASN PHE TYR PRO ARG GLU ALA LYS VAL GLN TRP LYS VAL          
SEQRES  13 M  220  ASP ASN ALA LEU GLN SER GLY ASN SER GLN GLU SER VAL          
SEQRES  14 M  220  THR GLU GLN ASP SER LYS ASP SER THR TYR SER LEU SER          
SEQRES  15 M  220  SER THR LEU THR LEU SER LYS ALA ASP TYR GLU LYS HIS          
SEQRES  16 M  220  LYS VAL TYR ALA CYS GLU VAL THR HIS GLN GLY LEU SER          
SEQRES  17 M  220  SER PRO VAL THR LYS SER PHE ASN ARG GLY GLU CYS              
SEQRES   1 U  173  GLU PRO PRO THR ALA CYS ARG GLU LYS GLN TYR LEU ILE          
SEQRES   2 U  173  ASN SER GLN CYS CYS SER LEU CYS GLN PRO GLY GLN LYS          
SEQRES   3 U  173  LEU VAL SER ASP CYS THR GLU PHE THR GLU THR GLU CYS          
SEQRES   4 U  173  LEU PRO CYS GLY GLU SER GLU PHE LEU ASP THR TRP ASN          
SEQRES   5 U  173  ARG GLU THR HIS CYS HIS GLN HIS LYS TYR CYS ASP PRO          
SEQRES   6 U  173  ASN LEU GLY LEU ARG VAL GLN GLN LYS GLY THR SER GLU          
SEQRES   7 U  173  THR ASP THR ILE CYS THR CYS GLU GLU GLY TRP HIS CYS          
SEQRES   8 U  173  THR SER GLU ALA CYS GLU SER CYS VAL LEU HIS ARG SER          
SEQRES   9 U  173  CYS SER PRO GLY PHE GLY VAL LYS GLN ILE ALA THR GLY          
SEQRES  10 U  173  VAL SER ASP THR ILE CYS GLU PRO CYS PRO VAL GLY PHE          
SEQRES  11 U  173  PHE SER ASN VAL SER SER ALA PHE GLU LYS CYS HIS PRO          
SEQRES  12 U  173  TRP THR SER CYS GLU THR LYS ASP LEU VAL VAL GLN GLN          
SEQRES  13 U  173  ALA GLY THR ASN LYS THR ASP VAL VAL CYS GLY PRO GLN          
SEQRES  14 U  173  ASP ARG LEU ARG                                              
SEQRES   1 V  173  GLU PRO PRO THR ALA CYS ARG GLU LYS GLN TYR LEU ILE          
SEQRES   2 V  173  ASN SER GLN CYS CYS SER LEU CYS GLN PRO GLY GLN LYS          
SEQRES   3 V  173  LEU VAL SER ASP CYS THR GLU PHE THR GLU THR GLU CYS          
SEQRES   4 V  173  LEU PRO CYS GLY GLU SER GLU PHE LEU ASP THR TRP ASN          
SEQRES   5 V  173  ARG GLU THR HIS CYS HIS GLN HIS LYS TYR CYS ASP PRO          
SEQRES   6 V  173  ASN LEU GLY LEU ARG VAL GLN GLN LYS GLY THR SER GLU          
SEQRES   7 V  173  THR ASP THR ILE CYS THR CYS GLU GLU GLY TRP HIS CYS          
SEQRES   8 V  173  THR SER GLU ALA CYS GLU SER CYS VAL LEU HIS ARG SER          
SEQRES   9 V  173  CYS SER PRO GLY PHE GLY VAL LYS GLN ILE ALA THR GLY          
SEQRES  10 V  173  VAL SER ASP THR ILE CYS GLU PRO CYS PRO VAL GLY PHE          
SEQRES  11 V  173  PHE SER ASN VAL SER SER ALA PHE GLU LYS CYS HIS PRO          
SEQRES  12 V  173  TRP THR SER CYS GLU THR LYS ASP LEU VAL VAL GLN GLN          
SEQRES  13 V  173  ALA GLY THR ASN LYS THR ASP VAL VAL CYS GLY PRO GLN          
SEQRES  14 V  173  ASP ARG LEU ARG                                              
HET    SO4  A 301       5                                                       
HET    SO4  H 301       5                                                       
HET    SO4  H 302       5                                                       
HET    SO4  I 201       5                                                       
HET    SO4  L 401       5                                                       
HETNAM     SO4 SULFATE ION                                                      
FORMUL  16  SO4    5(O4 S 2-)                                                   
FORMUL  21  HOH   *87(H2 O)                                                     
HELIX    1 AA1 THR A   28  TYR A   32  5                                   5    
HELIX    2 AA2 ASP A   62  LYS A   65  5                                   4    
HELIX    3 AA3 ARG A   87  THR A   91  5                                   5    
HELIX    4 AA4 SER A  159  ALA A  161  5                                   3    
HELIX    5 AA5 SER A  190  LEU A  192  5                                   3    
HELIX    6 AA6 PRO A  205  ASN A  207  5                                   3    
HELIX    7 AA7 GLN B   85  VAL B   89  5                                   5    
HELIX    8 AA8 SER B  127  LYS B  132  1                                   6    
HELIX    9 AA9 LYS B  189  LYS B  194  1                                   6    
HELIX   10 AB1 THR C   28  TYR C   32  5                                   5    
HELIX   11 AB2 ARG C   87  THR C   91  5                                   5    
HELIX   12 AB3 LYS C  204  ASN C  207  5                                   4    
HELIX   13 AB4 GLN D   85  VAL D   89  5                                   5    
HELIX   14 AB5 ASP D  128  SER D  133  5                                   6    
HELIX   15 AB6 LYS D  189  GLU D  193  1                                   5    
HELIX   16 AB7 ARG E   87  THR E   91  5                                   5    
HELIX   17 AB8 SER E  159  ALA E  161  5                                   3    
HELIX   18 AB9 LYS E  204  ASN E  207  5                                   4    
HELIX   19 AC1 GLN F   85  VAL F   89  5                                   5    
HELIX   20 AC2 GLU F  129  SER F  133  5                                   5    
HELIX   21 AC3 LYS F  189  LYS F  194  1                                   6    
HELIX   22 AC4 ASP G   84  LEU G   87  5                                   4    
HELIX   23 AC5 THR H   28  TYR H   32  5                                   5    
HELIX   24 AC6 ASP H   62  LYS H   65  5                                   4    
HELIX   25 AC7 ARG H   87  THR H   91  5                                   5    
HELIX   26 AC8 SER H  159  ALA H  161  5                                   3    
HELIX   27 AC9 SER H  190  GLY H  193  5                                   4    
HELIX   28 AD1 LYS H  204  ASN H  207  5                                   4    
HELIX   29 AD2 ASP J   84  GLY J   88  5                                   5    
HELIX   30 AD3 ASP K   62  LYS K   65  5                                   4    
HELIX   31 AD4 ARG K   87  THR K   91  5                                   5    
HELIX   32 AD5 SER L  127  SER L  133  1                                   7    
HELIX   33 AD6 LYS L  189  LYS L  194  1                                   6    
HELIX   34 AD7 GLN M   85  VAL M   89  5                                   5    
HELIX   35 AD8 ASP U   84  LEU U   87  5                                   4    
HELIX   36 AD9 ASP V   84  LEU V   87  5                                   4    
SHEET    1 AA1 4 GLN A   3  SER A   7  0                                        
SHEET    2 AA1 4 LEU A  18  SER A  25 -1  O  SER A  25   N  GLN A   3           
SHEET    3 AA1 4 SER A  78  MET A  83 -1  O  MET A  83   N  LEU A  18           
SHEET    4 AA1 4 PHE A  68  ASP A  73 -1  N  ASP A  73   O  SER A  78           
SHEET    1 AA2 6 GLY A  10  VAL A  12  0                                        
SHEET    2 AA2 6 THR A 110  VAL A 114  1  O  THR A 113   N  VAL A  12           
SHEET    3 AA2 6 ALA A  92  SER A  99 -1  N  TYR A  94   O  THR A 110           
SHEET    4 AA2 6 GLY A  33  GLN A  39 -1  N  VAL A  37   O  TYR A  95           
SHEET    5 AA2 6 LEU A  45  ILE A  51 -1  O  GLU A  46   N  ARG A  38           
SHEET    6 AA2 6 ILE A  58  TYR A  60 -1  O  TYR A  59   N  TYR A  50           
SHEET    1 AA3 4 GLY A  10  VAL A  12  0                                        
SHEET    2 AA3 4 THR A 110  VAL A 114  1  O  THR A 113   N  VAL A  12           
SHEET    3 AA3 4 ALA A  92  SER A  99 -1  N  TYR A  94   O  THR A 110           
SHEET    4 AA3 4 PHE A 103  TRP A 106 -1  O  VAL A 105   N  ARG A  98           
SHEET    1 AA4 4 SER A 123  LEU A 127  0                                        
SHEET    2 AA4 4 THR A 138  TYR A 148 -1  O  LEU A 144   N  PHE A 125           
SHEET    3 AA4 4 TYR A 179  PRO A 188 -1  O  VAL A 187   N  ALA A 139           
SHEET    4 AA4 4 VAL A 166  THR A 168 -1  N  HIS A 167   O  VAL A 184           
SHEET    1 AA5 4 SER A 123  LEU A 127  0                                        
SHEET    2 AA5 4 THR A 138  TYR A 148 -1  O  LEU A 144   N  PHE A 125           
SHEET    3 AA5 4 TYR A 179  PRO A 188 -1  O  VAL A 187   N  ALA A 139           
SHEET    4 AA5 4 VAL A 172  LEU A 173 -1  N  VAL A 172   O  SER A 180           
SHEET    1 AA6 3 VAL A 153  TRP A 157  0                                        
SHEET    2 AA6 3 CYS A 199  HIS A 203 -1  O  ASN A 200   N  SER A 156           
SHEET    3 AA6 3 THR A 208  LYS A 212 -1  O  VAL A 210   N  VAL A 201           
SHEET    1 AA7 4 MET B   4  SER B   7  0                                        
SHEET    2 AA7 4 ALA B  19  SER B  25 -1  O  LYS B  24   N  THR B   5           
SHEET    3 AA7 4 ASP B  76  ILE B  81 -1  O  ILE B  81   N  ALA B  19           
SHEET    4 AA7 4 PHE B  68  SER B  73 -1  N  SER B  69   O  THR B  80           
SHEET    1 AA8 6 SER B  10  SER B  14  0                                        
SHEET    2 AA8 6 LYS B 109  LYS B 113  1  O  LYS B 113   N  VAL B  13           
SHEET    3 AA8 6 ALA B  90  ASN B  96 -1  N  ALA B  90   O  LEU B 110           
SHEET    4 AA8 6 LEU B  39  GLN B  44 -1  N  PHE B  42   O  TYR B  93           
SHEET    5 AA8 6 LYS B  51  TYR B  55 -1  O  LYS B  51   N  GLN B  43           
SHEET    6 AA8 6 THR B  59  ARG B  60 -1  O  THR B  59   N  TYR B  55           
SHEET    1 AA9 2 LEU B  30  ASN B  31  0                                        
SHEET    2 AA9 2 LYS B  36  ASN B  37 -1  O  LYS B  36   N  ASN B  31           
SHEET    1 AB1 4 SER B 120  PHE B 124  0                                        
SHEET    2 AB1 4 THR B 135  PHE B 145 -1  O  LEU B 141   N  PHE B 122           
SHEET    3 AB1 4 TYR B 179  SER B 188 -1  O  LEU B 181   N  LEU B 142           
SHEET    4 AB1 4 SER B 165  VAL B 169 -1  N  SER B 168   O  SER B 182           
SHEET    1 AB2 4 ALA B 159  LEU B 160  0                                        
SHEET    2 AB2 4 LYS B 151  VAL B 156 -1  N  VAL B 156   O  ALA B 159           
SHEET    3 AB2 4 VAL B 197  THR B 203 -1  O  GLU B 201   N  GLN B 153           
SHEET    4 AB2 4 VAL B 211  ASN B 216 -1  O  VAL B 211   N  VAL B 202           
SHEET    1 AB3 4 GLN C   3  SER C   7  0                                        
SHEET    2 AB3 4 SER C  17  SER C  25 -1  O  ALA C  23   N  VAL C   5           
SHEET    3 AB3 4 SER C  78  ASN C  84 -1  O  LEU C  79   N  CYS C  22           
SHEET    4 AB3 4 PHE C  68  ASP C  73 -1  N  SER C  71   O  TYR C  80           
SHEET    1 AB4 6 LEU C  11  VAL C  12  0                                        
SHEET    2 AB4 6 THR C 110  VAL C 114  1  O  THR C 113   N  VAL C  12           
SHEET    3 AB4 6 ALA C  92  SER C  99 -1  N  TYR C  94   O  THR C 110           
SHEET    4 AB4 6 GLY C  33  GLN C  39 -1  N  VAL C  37   O  TYR C  95           
SHEET    5 AB4 6 GLU C  46  ILE C  51 -1  O  GLU C  46   N  ARG C  38           
SHEET    6 AB4 6 ILE C  58  TYR C  60 -1  O  TYR C  59   N  TYR C  50           
SHEET    1 AB5 4 LEU C  11  VAL C  12  0                                        
SHEET    2 AB5 4 THR C 110  VAL C 114  1  O  THR C 113   N  VAL C  12           
SHEET    3 AB5 4 ALA C  92  SER C  99 -1  N  TYR C  94   O  THR C 110           
SHEET    4 AB5 4 PHE C 103  TRP C 106 -1  O  VAL C 105   N  ARG C  98           
SHEET    1 AB6 4 SER C 123  LEU C 127  0                                        
SHEET    2 AB6 4 THR C 138  TYR C 148 -1  O  GLY C 142   N  LEU C 127           
SHEET    3 AB6 4 TYR C 179  PRO C 188 -1  O  TYR C 179   N  TYR C 148           
SHEET    4 AB6 4 VAL C 166  THR C 168 -1  N  HIS C 167   O  VAL C 184           
SHEET    1 AB7 4 SER C 123  LEU C 127  0                                        
SHEET    2 AB7 4 THR C 138  TYR C 148 -1  O  GLY C 142   N  LEU C 127           
SHEET    3 AB7 4 TYR C 179  PRO C 188 -1  O  TYR C 179   N  TYR C 148           
SHEET    4 AB7 4 VAL C 172  LEU C 173 -1  N  VAL C 172   O  SER C 180           
SHEET    1 AB8 3 THR C 154  TRP C 157  0                                        
SHEET    2 AB8 3 TYR C 197  HIS C 203 -1  O  ASN C 200   N  SER C 156           
SHEET    3 AB8 3 THR C 208  VAL C 210 -1  O  VAL C 210   N  VAL C 201           
SHEET    1 AB9 3 THR C 154  TRP C 157  0                                        
SHEET    2 AB9 3 TYR C 197  HIS C 203 -1  O  ASN C 200   N  SER C 156           
SHEET    3 AB9 3 LYS C 213  VAL C 214 -1  O  VAL C 214   N  TYR C 197           
SHEET    1 AC1 4 MET D   4  SER D   7  0                                        
SHEET    2 AC1 4 ALA D  19  SER D  25 -1  O  ASN D  22   N  SER D   7           
SHEET    3 AC1 4 ASP D  76  ILE D  81 -1  O  PHE D  77   N  CYS D  23           
SHEET    4 AC1 4 PHE D  68  SER D  73 -1  N  SER D  69   O  THR D  80           
SHEET    1 AC2 6 SER D  10  SER D  14  0                                        
SHEET    2 AC2 6 THR D 108  LYS D 113  1  O  LYS D 113   N  VAL D  13           
SHEET    3 AC2 6 ALA D  90  ASN D  96 -1  N  ALA D  90   O  LEU D 110           
SHEET    4 AC2 6 LEU D  39  GLN D  44 -1  N  GLN D  44   O  VAL D  91           
SHEET    5 AC2 6 LYS D  51  TYR D  55 -1  O  LYS D  51   N  GLN D  43           
SHEET    6 AC2 6 THR D  59  ARG D  60 -1  O  THR D  59   N  TYR D  55           
SHEET    1 AC3 4 SER D  10  SER D  14  0                                        
SHEET    2 AC3 4 THR D 108  LYS D 113  1  O  LYS D 113   N  VAL D  13           
SHEET    3 AC3 4 ALA D  90  ASN D  96 -1  N  ALA D  90   O  LEU D 110           
SHEET    4 AC3 4 THR D 103  PHE D 104 -1  O  THR D 103   N  ASN D  96           
SHEET    1 AC4 2 LEU D  30  ASN D  31  0                                        
SHEET    2 AC4 2 LYS D  36  ASN D  37 -1  O  LYS D  36   N  ASN D  31           
SHEET    1 AC5 4 SER D 120  PHE D 124  0                                        
SHEET    2 AC5 4 THR D 135  PHE D 145 -1  O  ASN D 143   N  SER D 120           
SHEET    3 AC5 4 TYR D 179  SER D 188 -1  O  LEU D 187   N  ALA D 136           
SHEET    4 AC5 4 SER D 165  VAL D 169 -1  N  GLN D 166   O  THR D 184           
SHEET    1 AC6 3 ALA D 150  LYS D 151  0                                        
SHEET    2 AC6 3 VAL D 197  HIS D 204 -1  O  THR D 203   N  LYS D 151           
SHEET    3 AC6 3 TRP D 154  VAL D 156 -1  N  LYS D 155   O  ALA D 199           
SHEET    1 AC7 3 ALA D 150  LYS D 151  0                                        
SHEET    2 AC7 3 VAL D 197  HIS D 204 -1  O  THR D 203   N  LYS D 151           
SHEET    3 AC7 3 VAL D 211  ASN D 216 -1  O  LYS D 213   N  CYS D 200           
SHEET    1 AC8 4 GLN E   3  SER E   7  0                                        
SHEET    2 AC8 4 LEU E  18  SER E  25 -1  O  SER E  21   N  SER E   7           
SHEET    3 AC8 4 SER E  78  MET E  83 -1  O  MET E  83   N  LEU E  18           
SHEET    4 AC8 4 THR E  69  ASP E  73 -1  N  ASP E  73   O  SER E  78           
SHEET    1 AC9 6 GLY E  10  VAL E  12  0                                        
SHEET    2 AC9 6 THR E 110  VAL E 114  1  O  THR E 113   N  GLY E  10           
SHEET    3 AC9 6 ALA E  92  SER E  99 -1  N  TYR E  94   O  THR E 110           
SHEET    4 AC9 6 GLY E  33  GLN E  39 -1  N  GLY E  33   O  SER E  99           
SHEET    5 AC9 6 LEU E  45  ILE E  51 -1  O  GLU E  46   N  ARG E  38           
SHEET    6 AC9 6 ILE E  58  TYR E  60 -1  O  TYR E  59   N  TYR E  50           
SHEET    1 AD1 4 GLY E  10  VAL E  12  0                                        
SHEET    2 AD1 4 THR E 110  VAL E 114  1  O  THR E 113   N  GLY E  10           
SHEET    3 AD1 4 ALA E  92  SER E  99 -1  N  TYR E  94   O  THR E 110           
SHEET    4 AD1 4 PHE E 103  TRP E 106 -1  O  VAL E 105   N  ARG E  98           
SHEET    1 AD2 4 SER E 123  LEU E 127  0                                        
SHEET    2 AD2 4 THR E 138  TYR E 148 -1  O  LYS E 146   N  SER E 123           
SHEET    3 AD2 4 LEU E 178  PRO E 188 -1  O  TYR E 179   N  TYR E 148           
SHEET    4 AD2 4 VAL E 166  THR E 168 -1  N  HIS E 167   O  VAL E 184           
SHEET    1 AD3 4 SER E 123  LEU E 127  0                                        
SHEET    2 AD3 4 THR E 138  TYR E 148 -1  O  LYS E 146   N  SER E 123           
SHEET    3 AD3 4 LEU E 178  PRO E 188 -1  O  TYR E 179   N  TYR E 148           
SHEET    4 AD3 4 VAL E 172  GLN E 174 -1  N  GLN E 174   O  LEU E 178           
SHEET    1 AD4 3 THR E 154  TRP E 157  0                                        
SHEET    2 AD4 3 ILE E 198  HIS E 203 -1  O  ASN E 200   N  SER E 156           
SHEET    3 AD4 3 THR E 208  LYS E 213 -1  O  VAL E 210   N  VAL E 201           
SHEET    1 AD5 4 MET F   4  SER F   7  0                                        
SHEET    2 AD5 4 ALA F  19  SER F  25 -1  O  ASN F  22   N  SER F   7           
SHEET    3 AD5 4 ASP F  76  ILE F  81 -1  O  LEU F  79   N  ILE F  21           
SHEET    4 AD5 4 PHE F  68  SER F  73 -1  N  SER F  71   O  THR F  78           
SHEET    1 AD6 6 SER F  10  SER F  14  0                                        
SHEET    2 AD6 6 LYS F 109  LYS F 113  1  O  GLU F 111   N  LEU F  11           
SHEET    3 AD6 6 ALA F  90  ASN F  96 -1  N  ALA F  90   O  LEU F 110           
SHEET    4 AD6 6 LEU F  39  GLN F  44 -1  N  GLN F  44   O  VAL F  91           
SHEET    5 AD6 6 LYS F  51  TYR F  55 -1  O  LYS F  51   N  GLN F  43           
SHEET    6 AD6 6 THR F  59  ARG F  60 -1  O  THR F  59   N  TYR F  55           
SHEET    1 AD7 4 SER F  10  SER F  14  0                                        
SHEET    2 AD7 4 LYS F 109  LYS F 113  1  O  GLU F 111   N  LEU F  11           
SHEET    3 AD7 4 ALA F  90  ASN F  96 -1  N  ALA F  90   O  LEU F 110           
SHEET    4 AD7 4 THR F 103  PHE F 104 -1  O  THR F 103   N  ASN F  96           
SHEET    1 AD8 2 LEU F  30  ASN F  31  0                                        
SHEET    2 AD8 2 LYS F  36  ASN F  37 -1  O  LYS F  36   N  ASN F  31           
SHEET    1 AD9 4 PHE F 122  ILE F 123  0                                        
SHEET    2 AD9 4 THR F 135  PHE F 145 -1  O  LEU F 141   N  PHE F 122           
SHEET    3 AD9 4 THR F 184  SER F 188 -1  O  LEU F 187   N  ALA F 136           
SHEET    4 AD9 4 SER F 165  GLN F 166 -1  N  GLN F 166   O  THR F 184           
SHEET    1 AE1 3 PHE F 122  ILE F 123  0                                        
SHEET    2 AE1 3 THR F 135  PHE F 145 -1  O  LEU F 141   N  PHE F 122           
SHEET    3 AE1 3 TYR F 179  LEU F 181 -1  O  LEU F 181   N  LEU F 142           
SHEET    1 AE2 4 ALA F 159  LEU F 160  0                                        
SHEET    2 AE2 4 LYS F 151  VAL F 156 -1  N  VAL F 156   O  ALA F 159           
SHEET    3 AE2 4 VAL F 197  THR F 203 -1  O  GLU F 201   N  GLN F 153           
SHEET    4 AE2 4 VAL F 211  THR F 212 -1  O  VAL F 211   N  VAL F 202           
SHEET    1 AE3 4 ALA F 159  LEU F 160  0                                        
SHEET    2 AE3 4 LYS F 151  VAL F 156 -1  N  VAL F 156   O  ALA F 159           
SHEET    3 AE3 4 VAL F 197  THR F 203 -1  O  GLU F 201   N  GLN F 153           
SHEET    4 AE3 4 PHE F 215  ASN F 216 -1  O  PHE F 215   N  TYR F 198           
SHEET    1 AE4 2 GLN G  30  ILE G  33  0                                        
SHEET    2 AE4 2 GLN G  36  SER G  39 -1  O  CYS G  38   N  TYR G  31           
SHEET    1 AE5 2 GLN G  45  SER G  49  0                                        
SHEET    2 AE5 2 GLU G  58  PRO G  61 -1  O  LEU G  60   N  LYS G  46           
SHEET    1 AE6 2 GLU G  66  PHE G  67  0                                        
SHEET    2 AE6 2 HIS G  78  GLN G  79 -1  O  HIS G  78   N  PHE G  67           
SHEET    1 AE7 2 LEU G  89  GLN G  93  0                                        
SHEET    2 AE7 2 ILE G 102  CYS G 105 -1  O  THR G 104   N  ARG G  90           
SHEET    1 AE8 2 TRP G 109  CYS G 111  0                                        
SHEET    2 AE8 2 CYS G 119  LEU G 121 -1  O  VAL G 120   N  HIS G 110           
SHEET    1 AE9 2 GLY G 130  VAL G 131  0                                        
SHEET    2 AE9 2 CYS G 143  GLU G 144 -1  O  GLU G 144   N  GLY G 130           
SHEET    1 AF1 4 GLN H   3  SER H   7  0                                        
SHEET    2 AF1 4 SER H  17  SER H  25 -1  O  SER H  25   N  GLN H   3           
SHEET    3 AF1 4 SER H  78  ASN H  84 -1  O  MET H  83   N  LEU H  18           
SHEET    4 AF1 4 PHE H  68  ASP H  73 -1  N  SER H  71   O  TYR H  80           
SHEET    1 AF2 6 GLY H  10  VAL H  12  0                                        
SHEET    2 AF2 6 THR H 110  VAL H 114  1  O  THR H 113   N  GLY H  10           
SHEET    3 AF2 6 ALA H  92  SER H  99 -1  N  ALA H  92   O  VAL H 112           
SHEET    4 AF2 6 GLY H  33  GLN H  39 -1  N  VAL H  37   O  TYR H  95           
SHEET    5 AF2 6 GLU H  46  ILE H  51 -1  O  GLU H  46   N  ARG H  38           
SHEET    6 AF2 6 ILE H  58  TYR H  60 -1  O  TYR H  59   N  TYR H  50           
SHEET    1 AF3 4 GLY H  10  VAL H  12  0                                        
SHEET    2 AF3 4 THR H 110  VAL H 114  1  O  THR H 113   N  GLY H  10           
SHEET    3 AF3 4 ALA H  92  SER H  99 -1  N  ALA H  92   O  VAL H 112           
SHEET    4 AF3 4 PHE H 103  TRP H 106 -1  O  VAL H 105   N  ARG H  98           
SHEET    1 AF4 4 SER H 123  LEU H 127  0                                        
SHEET    2 AF4 4 THR H 138  TYR H 148 -1  O  LEU H 144   N  PHE H 125           
SHEET    3 AF4 4 TYR H 179  PRO H 188 -1  O  TYR H 179   N  TYR H 148           
SHEET    4 AF4 4 VAL H 166  THR H 168 -1  N  HIS H 167   O  VAL H 184           
SHEET    1 AF5 4 SER H 123  LEU H 127  0                                        
SHEET    2 AF5 4 THR H 138  TYR H 148 -1  O  LEU H 144   N  PHE H 125           
SHEET    3 AF5 4 TYR H 179  PRO H 188 -1  O  TYR H 179   N  TYR H 148           
SHEET    4 AF5 4 VAL H 172  LEU H 173 -1  N  VAL H 172   O  SER H 180           
SHEET    1 AF6 3 THR H 154  TRP H 157  0                                        
SHEET    2 AF6 3 TYR H 197  HIS H 203 -1  O  ASN H 200   N  SER H 156           
SHEET    3 AF6 3 THR H 208  VAL H 214 -1  O  THR H 208   N  HIS H 203           
SHEET    1 AF7 2 GLN I  30  ILE I  33  0                                        
SHEET    2 AF7 2 GLN I  36  SER I  39 -1  O  CYS I  38   N  TYR I  31           
SHEET    1 AF8 2 GLN I  45  SER I  49  0                                        
SHEET    2 AF8 2 GLU I  58  PRO I  61 -1  O  GLU I  58   N  VAL I  48           
SHEET    1 AF9 2 GLU I  66  PHE I  67  0                                        
SHEET    2 AF9 2 HIS I  78  GLN I  79 -1  O  HIS I  78   N  PHE I  67           
SHEET    1 AG1 2 ARG I  90  GLN I  93  0                                        
SHEET    2 AG1 2 ILE I 102  THR I 104 -1  O  THR I 104   N  ARG I  90           
SHEET    1 AG2 2 HIS I 110  CYS I 111  0                                        
SHEET    2 AG2 2 CYS I 119  VAL I 120 -1  O  VAL I 120   N  HIS I 110           
SHEET    1 AG3 2 GLN J  30  LEU J  32  0                                        
SHEET    2 AG3 2 CYS J  37  SER J  39 -1  O  CYS J  38   N  TYR J  31           
SHEET    1 AG4 2 GLN J  45  SER J  49  0                                        
SHEET    2 AG4 2 GLU J  58  PRO J  61 -1  O  LEU J  60   N  LYS J  46           
SHEET    1 AG5 2 ARG J  90  GLN J  93  0                                        
SHEET    2 AG5 2 ILE J 102  THR J 104 -1  O  THR J 104   N  ARG J  90           
SHEET    1 AG6 4 GLN K   3  SER K   7  0                                        
SHEET    2 AG6 4 SER K  17  SER K  25 -1  O  SER K  25   N  GLN K   3           
SHEET    3 AG6 4 SER K  78  ASN K  84 -1  O  LEU K  79   N  CYS K  22           
SHEET    4 AG6 4 ILE K  70  ASP K  73 -1  N  SER K  71   O  TYR K  80           
SHEET    1 AG7 6 GLY K  10  LEU K  11  0                                        
SHEET    2 AG7 6 THR K 110  THR K 113  1  O  THR K 113   N  GLY K  10           
SHEET    3 AG7 6 ALA K  92  SER K  99 -1  N  TYR K  94   O  THR K 110           
SHEET    4 AG7 6 GLY K  33  GLN K  39 -1  N  GLY K  33   O  SER K  99           
SHEET    5 AG7 6 LEU K  45  ILE K  51 -1  O  ILE K  51   N  MET K  34           
SHEET    6 AG7 6 ILE K  58  TYR K  60 -1  O  TYR K  59   N  TYR K  50           
SHEET    1 AG8 4 GLY K  10  LEU K  11  0                                        
SHEET    2 AG8 4 THR K 110  THR K 113  1  O  THR K 113   N  GLY K  10           
SHEET    3 AG8 4 ALA K  92  SER K  99 -1  N  TYR K  94   O  THR K 110           
SHEET    4 AG8 4 PHE K 103  TRP K 106 -1  O  VAL K 105   N  ARG K  98           
SHEET    1 AG9 4 MET L   4  SER L   7  0                                        
SHEET    2 AG9 4 ALA L  19  SER L  25 -1  O  LYS L  24   N  THR L   5           
SHEET    3 AG9 4 ASP L  76  ILE L  81 -1  O  ILE L  81   N  ALA L  19           
SHEET    4 AG9 4 PHE L  68  SER L  73 -1  N  SER L  71   O  THR L  78           
SHEET    1 AH1 6 SER L  10  SER L  14  0                                        
SHEET    2 AH1 6 THR L 108  LYS L 113  1  O  GLU L 111   N  LEU L  11           
SHEET    3 AH1 6 ALA L  90  ASN L  96 -1  N  TYR L  92   O  THR L 108           
SHEET    4 AH1 6 LEU L  39  GLN L  44 -1  N  GLN L  44   O  VAL L  91           
SHEET    5 AH1 6 LYS L  51  TYR L  55 -1  O  LEU L  53   N  TRP L  41           
SHEET    6 AH1 6 THR L  59  ARG L  60 -1  O  THR L  59   N  TYR L  55           
SHEET    1 AH2 2 LEU L  30  ASN L  31  0                                        
SHEET    2 AH2 2 LYS L  36  ASN L  37 -1  O  LYS L  36   N  ASN L  31           
SHEET    1 AH3 4 SER L 120  PHE L 124  0                                        
SHEET    2 AH3 4 THR L 135  PHE L 145 -1  O  VAL L 139   N  PHE L 124           
SHEET    3 AH3 4 TYR L 179  SER L 188 -1  O  TYR L 179   N  PHE L 145           
SHEET    4 AH3 4 SER L 165  VAL L 169 -1  N  SER L 168   O  SER L 182           
SHEET    1 AH4 4 ALA L 159  LEU L 160  0                                        
SHEET    2 AH4 4 LYS L 151  VAL L 156 -1  N  VAL L 156   O  ALA L 159           
SHEET    3 AH4 4 VAL L 197  THR L 203 -1  O  GLU L 201   N  GLN L 153           
SHEET    4 AH4 4 VAL L 211  ASN L 216 -1  O  VAL L 211   N  VAL L 202           
SHEET    1 AH5 4 MET M   4  THR M   5  0                                        
SHEET    2 AH5 4 ALA M  19  SER M  25 -1  O  LYS M  24   N  THR M   5           
SHEET    3 AH5 4 ASP M  76  ILE M  81 -1  O  PHE M  77   N  CYS M  23           
SHEET    4 AH5 4 PHE M  68  SER M  73 -1  N  SER M  71   O  THR M  78           
SHEET    1 AH6 6 SER M  10  VAL M  13  0                                        
SHEET    2 AH6 6 THR M 108  ILE M 112  1  O  LYS M 109   N  LEU M  11           
SHEET    3 AH6 6 VAL M  91  ASN M  96 -1  N  TYR M  92   O  THR M 108           
SHEET    4 AH6 6 LEU M  39  GLN M  44 -1  N  PHE M  42   O  TYR M  93           
SHEET    5 AH6 6 PRO M  50  TYR M  55 -1  O  LYS M  51   N  GLN M  43           
SHEET    6 AH6 6 THR M  59  ARG M  60 -1  O  THR M  59   N  TYR M  55           
SHEET    1 AH7 4 SER M  10  VAL M  13  0                                        
SHEET    2 AH7 4 THR M 108  ILE M 112  1  O  LYS M 109   N  LEU M  11           
SHEET    3 AH7 4 VAL M  91  ASN M  96 -1  N  TYR M  92   O  THR M 108           
SHEET    4 AH7 4 THR M 103  PHE M 104 -1  O  THR M 103   N  ASN M  96           
SHEET    1 AH8 2 LEU M  30  ASN M  31  0                                        
SHEET    2 AH8 2 LYS M  36  ASN M  37 -1  O  LYS M  36   N  ASN M  31           
SHEET    1 AH9 2 GLN U  30  ILE U  33  0                                        
SHEET    2 AH9 2 GLN U  36  SER U  39 -1  O  GLN U  36   N  ILE U  33           
SHEET    1 AI1 2 GLN U  45  SER U  49  0                                        
SHEET    2 AI1 2 GLU U  58  PRO U  61 -1  O  GLU U  58   N  VAL U  48           
SHEET    1 AI2 2 GLU U  66  PHE U  67  0                                        
SHEET    2 AI2 2 HIS U  78  GLN U  79 -1  O  HIS U  78   N  PHE U  67           
SHEET    1 AI3 2 LEU U  89  GLN U  93  0                                        
SHEET    2 AI3 2 ILE U 102  CYS U 105 -1  O  ILE U 102   N  GLN U  93           
SHEET    1 AI4 2 TRP U 109  HIS U 110  0                                        
SHEET    2 AI4 2 VAL U 120  LEU U 121 -1  O  VAL U 120   N  HIS U 110           
SHEET    1 AI5 2 GLU V  66  PHE V  67  0                                        
SHEET    2 AI5 2 HIS V  78  GLN V  79 -1  O  HIS V  78   N  PHE V  67           
SHEET    1 AI6 2 LEU V  89  GLN V  93  0                                        
SHEET    2 AI6 2 ILE V 102  CYS V 105 -1  O  ILE V 102   N  GLN V  92           
SSBOND   1 CYS A   22    CYS A   96                          1555   1555  2.06  
SSBOND   2 CYS A  143    CYS A  199                          1555   1555  2.10  
SSBOND   3 CYS B   23    CYS B   94                          1555   1555  2.07  
SSBOND   4 CYS B  140    CYS B  200                          1555   1555  2.10  
SSBOND   5 CYS C   22    CYS C   96                          1555   1555  2.06  
SSBOND   6 CYS C  143    CYS C  199                          1555   1555  2.07  
SSBOND   7 CYS D   23    CYS D   94                          1555   1555  2.08  
SSBOND   8 CYS D  140    CYS D  200                          1555   1555  2.08  
SSBOND   9 CYS E   22    CYS E   96                          1555   1555  2.05  
SSBOND  10 CYS F   23    CYS F   94                          1555   1555  2.09  
SSBOND  11 CYS F  140    CYS F  200                          1555   1555  2.05  
SSBOND  12 CYS G   26    CYS G   37                          1555   1555  2.04  
SSBOND  13 CYS G   38    CYS G   51                          1555   1555  2.04  
SSBOND  14 CYS G   41    CYS G   59                          1555   1555  2.04  
SSBOND  15 CYS G   62    CYS G   77                          1555   1555  2.05  
SSBOND  16 CYS G   83    CYS G  103                          1555   1555  2.05  
SSBOND  17 CYS G  105    CYS G  119                          1555   1555  2.05  
SSBOND  18 CYS G  111    CYS G  116                          1555   1555  2.08  
SSBOND  19 CYS G  125    CYS G  143                          1555   1555  2.04  
SSBOND  20 CYS H   22    CYS H   96                          1555   1555  2.05  
SSBOND  21 CYS H  143    CYS H  199                          1555   1555  2.07  
SSBOND  22 CYS H  219    CYS L  220                          1555   1555  2.04  
SSBOND  23 CYS I   26    CYS I   37                          1555   1555  2.07  
SSBOND  24 CYS I   38    CYS I   51                          1555   1555  2.05  
SSBOND  25 CYS I   41    CYS I   59                          1555   1555  2.04  
SSBOND  26 CYS I   62    CYS I   77                          1555   1555  2.06  
SSBOND  27 CYS I   83    CYS I  103                          1555   1555  1.99  
SSBOND  28 CYS I  105    CYS I  119                          1555   1555  2.05  
SSBOND  29 CYS I  111    CYS I  116                          1555   1555  2.05  
SSBOND  30 CYS J   26    CYS J   37                          1555   1555  2.05  
SSBOND  31 CYS J   38    CYS J   51                          1555   1555  2.03  
SSBOND  32 CYS J   41    CYS J   59                          1555   1555  2.04  
SSBOND  33 CYS J   62    CYS J   77                          1555   1555  2.04  
SSBOND  34 CYS J   83    CYS J  103                          1555   1555  2.01  
SSBOND  35 CYS L   23    CYS L   94                          1555   1555  2.09  
SSBOND  36 CYS L  140    CYS L  200                          1555   1555  2.08  
SSBOND  37 CYS U   26    CYS U   37                          1555   1555  2.14  
SSBOND  38 CYS U   38    CYS U   51                          1555   1555  2.05  
SSBOND  39 CYS U   41    CYS U   59                          1555   1555  2.05  
SSBOND  40 CYS U   62    CYS U   77                          1555   1555  2.07  
SSBOND  41 CYS U   83    CYS U  103                          1555   1555  2.04  
SSBOND  42 CYS U  105    CYS U  119                          1555   1555  2.04  
SSBOND  43 CYS U  111    CYS U  116                          1555   1555  2.06  
SSBOND  44 CYS U  125    CYS U  143                          1555   1555  2.06  
SSBOND  45 CYS V   41    CYS V   59                          1555   1555  2.05  
SSBOND  46 CYS V   62    CYS V   77                          1555   1555  2.07  
SSBOND  47 CYS V   83    CYS V  103                          1555   1555  2.02  
SSBOND  48 CYS V  105    CYS V  119                          1555   1555  2.04  
SSBOND  49 CYS V  111    CYS V  116                          1555   1555  2.05  
CISPEP   1 PHE A  149    PRO A  150          0        -4.36                     
CISPEP   2 GLU A  151    PRO A  152          0         2.21                     
CISPEP   3 SER B    7    PRO B    8          0         1.57                     
CISPEP   4 TYR B  100    PRO B  101          0         2.30                     
CISPEP   5 TYR B  146    PRO B  147          0         2.56                     
CISPEP   6 PHE C  149    PRO C  150          0        -5.44                     
CISPEP   7 GLU C  151    PRO C  152          0        -8.79                     
CISPEP   8 SER D    7    PRO D    8          0         0.52                     
CISPEP   9 TYR D  100    PRO D  101          0         4.41                     
CISPEP  10 TYR D  146    PRO D  147          0        -1.91                     
CISPEP  11 PHE E  149    PRO E  150          0         2.03                     
CISPEP  12 GLU E  151    PRO E  152          0        -5.62                     
CISPEP  13 SER F    7    PRO F    8          0         0.68                     
CISPEP  14 TYR F  100    PRO F  101          0         5.88                     
CISPEP  15 TYR F  146    PRO F  147          0         4.04                     
CISPEP  16 PHE H  149    PRO H  150          0        -1.99                     
CISPEP  17 GLU H  151    PRO H  152          0         2.22                     
CISPEP  18 SER L    7    PRO L    8          0         3.64                     
CISPEP  19 TYR L  100    PRO L  101          0        -4.29                     
CISPEP  20 TYR L  146    PRO L  147          0         4.46                     
CISPEP  21 SER M    7    PRO M    8          0         1.93                     
CISPEP  22 TYR M  100    PRO M  101          0         2.22                     
SITE     1 AC1  3 THR A 110  THR A 111  LYS A 204                               
SITE     1 AC2  3 THR H 110  THR H 111  LYS H 204                               
SITE     1 AC3  7 LEU H 144  VAL H 172  SER H 180  LEU H 181                    
SITE     2 AC3  7 SER H 182  SER L 182  THR L 184                               
SITE     1 AC4  4 THR I  70  TRP I  71  THR U  70  TRP U  71                    
SITE     1 AC5  4 GLN L  43  LYS L  45  GLN L  48  LYS L  51                    
CRYST1  254.840  224.035  111.358  90.00  98.00  90.00 C 1 2 1      20          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      0.003924  0.000000  0.000551        0.00000                         
SCALE2      0.000000  0.004464  0.000000        0.00000                         
SCALE3      0.000000  0.000000  0.009068        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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