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Database: PDB
Entry: 6PPK
LinkDB: 6PPK
Original site: 6PPK 
HEADER    RIBOSOME                                07-JUL-19   6PPK              
TITLE     RBGA+45SRBGA COMPLEX                                                  
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: 23S RRNA;                                                  
COMPND   3 CHAIN: A;                                                            
COMPND   4 MOL_ID: 2;                                                           
COMPND   5 MOLECULE: 5S RRNA;                                                   
COMPND   6 CHAIN: B;                                                            
COMPND   7 MOL_ID: 3;                                                           
COMPND   8 MOLECULE: 50S RIBOSOMAL PROTEIN L2;                                  
COMPND   9 CHAIN: C;                                                            
COMPND  10 MOL_ID: 4;                                                           
COMPND  11 MOLECULE: 50S RIBOSOMAL PROTEIN L3;                                  
COMPND  12 CHAIN: D;                                                            
COMPND  13 MOL_ID: 5;                                                           
COMPND  14 MOLECULE: 50S RIBOSOMAL PROTEIN L4;                                  
COMPND  15 CHAIN: E;                                                            
COMPND  16 MOL_ID: 6;                                                           
COMPND  17 MOLECULE: 50S RIBOSOMAL PROTEIN L5;                                  
COMPND  18 CHAIN: F;                                                            
COMPND  19 MOL_ID: 7;                                                           
COMPND  20 MOLECULE: 50S RIBOSOMAL PROTEIN L6;                                  
COMPND  21 CHAIN: G;                                                            
COMPND  22 MOL_ID: 8;                                                           
COMPND  23 MOLECULE: 50S RIBOSOMAL PROTEIN L13;                                 
COMPND  24 CHAIN: J;                                                            
COMPND  25 MOL_ID: 9;                                                           
COMPND  26 MOLECULE: 50S RIBOSOMAL PROTEIN L14;                                 
COMPND  27 CHAIN: K;                                                            
COMPND  28 MOL_ID: 10;                                                          
COMPND  29 MOLECULE: 50S RIBOSOMAL PROTEIN L15;                                 
COMPND  30 CHAIN: L;                                                            
COMPND  31 MOL_ID: 11;                                                          
COMPND  32 MOLECULE: 50S RIBOSOMAL PROTEIN L17;                                 
COMPND  33 CHAIN: N;                                                            
COMPND  34 MOL_ID: 12;                                                          
COMPND  35 MOLECULE: 50S RIBOSOMAL PROTEIN L18;                                 
COMPND  36 CHAIN: O;                                                            
COMPND  37 MOL_ID: 13;                                                          
COMPND  38 MOLECULE: 50S RIBOSOMAL PROTEIN L19;                                 
COMPND  39 CHAIN: P;                                                            
COMPND  40 MOL_ID: 14;                                                          
COMPND  41 MOLECULE: 50S RIBOSOMAL PROTEIN L20;                                 
COMPND  42 CHAIN: Q;                                                            
COMPND  43 MOL_ID: 15;                                                          
COMPND  44 MOLECULE: 50S RIBOSOMAL PROTEIN L21;                                 
COMPND  45 CHAIN: R;                                                            
COMPND  46 MOL_ID: 16;                                                          
COMPND  47 MOLECULE: 50S RIBOSOMAL PROTEIN L22;                                 
COMPND  48 CHAIN: S;                                                            
COMPND  49 MOL_ID: 17;                                                          
COMPND  50 MOLECULE: 50S RIBOSOMAL PROTEIN L23;                                 
COMPND  51 CHAIN: T;                                                            
COMPND  52 MOL_ID: 18;                                                          
COMPND  53 MOLECULE: 50S RIBOSOMAL PROTEIN L24;                                 
COMPND  54 CHAIN: U;                                                            
COMPND  55 MOL_ID: 19;                                                          
COMPND  56 MOLECULE: 50S RIBOSOMAL PROTEIN L27;                                 
COMPND  57 CHAIN: V;                                                            
COMPND  58 MOL_ID: 20;                                                          
COMPND  59 MOLECULE: 50S RIBOSOMAL PROTEIN L30;                                 
COMPND  60 CHAIN: Z;                                                            
COMPND  61 MOL_ID: 21;                                                          
COMPND  62 MOLECULE: 50S RIBOSOMAL PROTEIN L32;                                 
COMPND  63 CHAIN: b;                                                            
COMPND  64 MOL_ID: 22;                                                          
COMPND  65 MOLECULE: 50S RIBOSOMAL PROTEIN L29;                                 
COMPND  66 CHAIN: Y;                                                            
COMPND  67 MOL_ID: 23;                                                          
COMPND  68 MOLECULE: 50S RIBOSOMAL PROTEIN L34;                                 
COMPND  69 CHAIN: d;                                                            
COMPND  70 MOL_ID: 24;                                                          
COMPND  71 MOLECULE: RIBOSOME BIOGENESIS GTPASE A;                              
COMPND  72 CHAIN: W;                                                            
COMPND  73 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: BACILLUS SUBTILIS;                              
SOURCE   3 ORGANISM_TAXID: 1423;                                                
SOURCE   4 MOL_ID: 2;                                                           
SOURCE   5 ORGANISM_SCIENTIFIC: BACILLUS SUBTILIS;                              
SOURCE   6 ORGANISM_TAXID: 1423;                                                
SOURCE   7 MOL_ID: 3;                                                           
SOURCE   8 ORGANISM_SCIENTIFIC: BACILLUS SUBTILIS;                              
SOURCE   9 ORGANISM_TAXID: 1423;                                                
SOURCE  10 MOL_ID: 4;                                                           
SOURCE  11 ORGANISM_SCIENTIFIC: BACILLUS SUBTILIS;                              
SOURCE  12 ORGANISM_TAXID: 1423;                                                
SOURCE  13 MOL_ID: 5;                                                           
SOURCE  14 ORGANISM_SCIENTIFIC: BACILLUS SUBTILIS;                              
SOURCE  15 ORGANISM_TAXID: 1423;                                                
SOURCE  16 MOL_ID: 6;                                                           
SOURCE  17 ORGANISM_SCIENTIFIC: BACILLUS SUBTILIS;                              
SOURCE  18 ORGANISM_TAXID: 1423;                                                
SOURCE  19 MOL_ID: 7;                                                           
SOURCE  20 ORGANISM_SCIENTIFIC: BACILLUS SUBTILIS;                              
SOURCE  21 ORGANISM_TAXID: 1423;                                                
SOURCE  22 MOL_ID: 8;                                                           
SOURCE  23 ORGANISM_SCIENTIFIC: BACILLUS SUBTILIS;                              
SOURCE  24 ORGANISM_TAXID: 1423;                                                
SOURCE  25 MOL_ID: 9;                                                           
SOURCE  26 ORGANISM_SCIENTIFIC: BACILLUS SUBTILIS;                              
SOURCE  27 ORGANISM_TAXID: 1423;                                                
SOURCE  28 MOL_ID: 10;                                                          
SOURCE  29 ORGANISM_SCIENTIFIC: BACILLUS SUBTILIS;                              
SOURCE  30 ORGANISM_TAXID: 1423;                                                
SOURCE  31 MOL_ID: 11;                                                          
SOURCE  32 ORGANISM_SCIENTIFIC: BACILLUS SUBTILIS;                              
SOURCE  33 ORGANISM_TAXID: 1423;                                                
SOURCE  34 MOL_ID: 12;                                                          
SOURCE  35 ORGANISM_SCIENTIFIC: BACILLUS SUBTILIS;                              
SOURCE  36 ORGANISM_TAXID: 1423;                                                
SOURCE  37 MOL_ID: 13;                                                          
SOURCE  38 ORGANISM_SCIENTIFIC: BACILLUS SUBTILIS;                              
SOURCE  39 ORGANISM_TAXID: 1423;                                                
SOURCE  40 MOL_ID: 14;                                                          
SOURCE  41 ORGANISM_SCIENTIFIC: BACILLUS SUBTILIS;                              
SOURCE  42 ORGANISM_TAXID: 1423;                                                
SOURCE  43 MOL_ID: 15;                                                          
SOURCE  44 ORGANISM_SCIENTIFIC: BACILLUS SUBTILIS;                              
SOURCE  45 ORGANISM_TAXID: 1423;                                                
SOURCE  46 MOL_ID: 16;                                                          
SOURCE  47 ORGANISM_SCIENTIFIC: BACILLUS SUBTILIS;                              
SOURCE  48 ORGANISM_TAXID: 1423;                                                
SOURCE  49 MOL_ID: 17;                                                          
SOURCE  50 ORGANISM_SCIENTIFIC: BACILLUS SUBTILIS;                              
SOURCE  51 ORGANISM_TAXID: 1423;                                                
SOURCE  52 MOL_ID: 18;                                                          
SOURCE  53 ORGANISM_SCIENTIFIC: BACILLUS SUBTILIS;                              
SOURCE  54 ORGANISM_TAXID: 1423;                                                
SOURCE  55 MOL_ID: 19;                                                          
SOURCE  56 ORGANISM_SCIENTIFIC: BACILLUS SUBTILIS;                              
SOURCE  57 ORGANISM_TAXID: 1423;                                                
SOURCE  58 MOL_ID: 20;                                                          
SOURCE  59 ORGANISM_SCIENTIFIC: BACILLUS SUBTILIS;                              
SOURCE  60 ORGANISM_TAXID: 1423;                                                
SOURCE  61 MOL_ID: 21;                                                          
SOURCE  62 ORGANISM_SCIENTIFIC: BACILLUS SUBTILIS;                              
SOURCE  63 ORGANISM_TAXID: 1423;                                                
SOURCE  64 MOL_ID: 22;                                                          
SOURCE  65 ORGANISM_SCIENTIFIC: BACILLUS SUBTILIS;                              
SOURCE  66 ORGANISM_TAXID: 1423;                                                
SOURCE  67 MOL_ID: 23;                                                          
SOURCE  68 ORGANISM_SCIENTIFIC: BACILLUS SUBTILIS;                              
SOURCE  69 ORGANISM_TAXID: 1423;                                                
SOURCE  70 MOL_ID: 24;                                                          
SOURCE  71 ORGANISM_SCIENTIFIC: BACILLUS SUBTILIS;                              
SOURCE  72 ORGANISM_TAXID: 1423;                                                
SOURCE  73 GENE: B4417_3550;                                                    
SOURCE  74 EXPRESSION_SYSTEM: ESCHERICHIA COLI BL21;                            
SOURCE  75 EXPRESSION_SYSTEM_TAXID: 511693;                                     
SOURCE  76 EXPRESSION_SYSTEM_STRAIN: BL21                                       
KEYWDS    RIBOSOME ASSEMBLY, 50S SUBUNIT, RBGA, YLQF, RIBOSOME                  
EXPDTA    ELECTRON MICROSCOPY                                                   
AUTHOR    J.ORTEGA                                                              
REVDAT   2   18-DEC-19 6PPK    1       REMARK                                   
REVDAT   1   18-SEP-19 6PPK    0                                                
JRNL        AUTH   A.SEFFOUH,N.JAIN,D.JAHAGIRDAR,K.BASU,A.RAZI,X.NI,A.GUARNE,   
JRNL        AUTH 2 R.A.BRITTON,J.ORTEGA                                         
JRNL        TITL   RBGA TRIGGERS FOLDING OF THE 50S SUBUNIT FUNCTIONAL SITES    
JRNL        REF    NUCLEIC ACIDS RES.                         2019              
JRNL        REFN                   ESSN 1362-4962                               
REMARK   2                                                                      
REMARK   2 RESOLUTION.    4.40 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   SOFTWARE PACKAGES      : EPU, GCTF, RELION, RELION, RELION,        
REMARK   3                            RELION                                    
REMARK   3   RECONSTRUCTION SCHEMA  : NULL                                      
REMARK   3                                                                      
REMARK   3 EM MAP-MODEL FITTING AND REFINEMENT                                  
REMARK   3   PDB ENTRY                    : NULL                                
REMARK   3   REFINEMENT SPACE             : NULL                                
REMARK   3   REFINEMENT PROTOCOL          : NULL                                
REMARK   3   REFINEMENT TARGET            : NULL                                
REMARK   3   OVERALL ANISOTROPIC B VALUE  : NULL                                
REMARK   3                                                                      
REMARK   3 FITTING PROCEDURE : NULL                                             
REMARK   3                                                                      
REMARK   3 EM IMAGE RECONSTRUCTION STATISTICS                                   
REMARK   3   NOMINAL PIXEL SIZE (ANGSTROMS)    : NULL                           
REMARK   3   ACTUAL PIXEL SIZE  (ANGSTROMS)    : NULL                           
REMARK   3   EFFECTIVE RESOLUTION (ANGSTROMS)  : 4.400                          
REMARK   3   NUMBER OF PARTICLES               : 81392                          
REMARK   3   CTF CORRECTION METHOD             : PHASE FLIPPING AND AMPLITUDE   
REMARK   3                                       CORRECTION                     
REMARK   3                                                                      
REMARK   3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL                    
REMARK   3                                                                      
REMARK   3 OTHER DETAILS: NULL                                                  
REMARK   4                                                                      
REMARK   4 6PPK COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 08-JUL-19.                  
REMARK 100 THE DEPOSITION ID IS D_1000241396.                                   
REMARK 245                                                                      
REMARK 245 EXPERIMENTAL DETAILS                                                 
REMARK 245   RECONSTRUCTION METHOD          : SINGLE PARTICLE                   
REMARK 245   SPECIMEN TYPE                  : NULL                              
REMARK 245                                                                      
REMARK 245 ELECTRON MICROSCOPE SAMPLE                                           
REMARK 245   SAMPLE TYPE                    : PARTICLE                          
REMARK 245   PARTICLE TYPE                  : POINT                             
REMARK 245   NAME OF SAMPLE                 : RBGA + 45SRBGA RIBOSOMAL          
REMARK 245                                    ASSEMBLY INTERMEDIATE COMPLEX     
REMARK 245   SAMPLE CONCENTRATION (MG ML-1) : NULL                              
REMARK 245   SAMPLE SUPPORT DETAILS         : UNSPECIFIED                       
REMARK 245   SAMPLE VITRIFICATION DETAILS   : CRYO-EM GRIDS WERE PREPARED BY    
REMARK 245                                    APPLYING A 3.6 MICROLITERS        
REMARK 245                                    VOLUME OF THE DILUTED SAMPLES     
REMARK 245                                    TO HOLEY CARBON GRIDS (C-FLAT     
REMARK 245                                    CF-2/2-2C-T) WITH A FRESHLY       
REMARK 245                                    APPLIED ADDITIONAL LAYER OF       
REMARK 245                                    CONTINUOUS THIN CARBON (5-10NM)   
REMARK 245                                    . GRIDS WERE BLOTTED FOR 3        
REMARK 245                                    SECONDS AND WITH A BLOT FORCE +1  
REMARK 245   SAMPLE BUFFER                  : NULL                              
REMARK 245   PH                             : 7.50                              
REMARK 245   SAMPLE DETAILS                 : 50S SUBUNIT ASSEMBLY              
REMARK 245  INTERMEDIATE GENERATED BY RBGA DEPLETION IN CELLS IN COMPLEX        
REMARK 245  WITH RBGA PROTEIN                                                   
REMARK 245                                                                      
REMARK 245 DATA ACQUISITION                                                     
REMARK 245   DATE OF EXPERIMENT                : NULL                           
REMARK 245   NUMBER OF MICROGRAPHS-IMAGES      : 1228                           
REMARK 245   TEMPERATURE (KELVIN)              : NULL                           
REMARK 245   MICROSCOPE MODEL                  : FEI TECNAI F20                 
REMARK 245   DETECTOR TYPE                     : GATAN K2 SUMMIT (4K X 4K)      
REMARK 245   MINIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MAXIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MINIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   MAXIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   NOMINAL CS                        : NULL                           
REMARK 245   IMAGING MODE                      : BRIGHT FIELD                   
REMARK 245   ELECTRON DOSE (ELECTRONS NM**-2)  : 43.00                          
REMARK 245   ILLUMINATION MODE                 : FLOOD BEAM                     
REMARK 245   NOMINAL MAGNIFICATION             : NULL                           
REMARK 245   CALIBRATED MAGNIFICATION          : NULL                           
REMARK 245   SOURCE                            : FIELD EMISSION GUN             
REMARK 245   ACCELERATION VOLTAGE (KV)         : 200                            
REMARK 245   IMAGING DETAILS                   : NULL                           
REMARK 247                                                                      
REMARK 247 ELECTRON MICROSCOPY                                                  
REMARK 247  THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON          
REMARK 247  MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE              
REMARK 247  THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES           
REMARK 247  ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION         
REMARK 247  OF THE STRUCTURE FACTORS.                                           
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: 24-MERIC                          
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E, F, G, J, K, L,         
REMARK 350                    AND CHAINS: N, O, P, Q, R, S, T, U, V,            
REMARK 350                    AND CHAINS: Z, b, Y, d, W                         
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465       G A     1                                                      
REMARK 465       G A     2                                                      
REMARK 465       C A   931                                                      
REMARK 465       C A   932                                                      
REMARK 465       C A   933                                                      
REMARK 465       U A   934                                                      
REMARK 465       A A   935                                                      
REMARK 465       C A   936                                                      
REMARK 465       C A   937                                                      
REMARK 465       G A   938                                                      
REMARK 465       G A   939                                                      
REMARK 465       G A   940                                                      
REMARK 465       U A   941                                                      
REMARK 465       U A   942                                                      
REMARK 465       A A   943                                                      
REMARK 465       C A   944                                                      
REMARK 465       C A   945                                                      
REMARK 465       G A  1108A                                                     
REMARK 465       C A  1108B                                                     
REMARK 465       U A  1108C                                                     
REMARK 465       U A  1108D                                                     
REMARK 465       A A  1108E                                                     
REMARK 465       G A  1108F                                                     
REMARK 465       A A  1108G                                                     
REMARK 465       A A  1108H                                                     
REMARK 465       G A  1108I                                                     
REMARK 465       C A  1108J                                                     
REMARK 465       C A  1121                                                      
REMARK 465       C A  1122                                                      
REMARK 465       A A  1123                                                      
REMARK 465       C A  1124                                                      
REMARK 465       C A  1125                                                      
REMARK 465       A A  1126                                                      
REMARK 465       U A  1136                                                      
REMARK 465       G A  1137                                                      
REMARK 465       C A  1138                                                      
REMARK 465       G A  1139                                                      
REMARK 465       U A  1140                                                      
REMARK 465       A A  1141                                                      
REMARK 465       A A  1142                                                      
REMARK 465       U A  1143                                                      
REMARK 465       A A  1144                                                      
REMARK 465       U A  1217                                                      
REMARK 465       U A  1218                                                      
REMARK 465       C A  1219                                                      
REMARK 465       U A  1863                                                      
REMARK 465       G A  1864                                                      
REMARK 465       C A  1865                                                      
REMARK 465       C A  1866                                                      
REMARK 465       C A  1867                                                      
REMARK 465       G A  1868                                                      
REMARK 465       G A  1869                                                      
REMARK 465       U A  1870                                                      
REMARK 465       G A  1871                                                      
REMARK 465       C A  1872                                                      
REMARK 465       U A  1873                                                      
REMARK 465       G A  1874                                                      
REMARK 465       G A  1875                                                      
REMARK 465       A A  1876                                                      
REMARK 465       A A  1877                                                      
REMARK 465       G A  1878                                                      
REMARK 465       G A  1879                                                      
REMARK 465       U A  1880                                                      
REMARK 465       U A  1881                                                      
REMARK 465       A A  1882                                                      
REMARK 465       A A  1883                                                      
REMARK 465       G A  1884                                                      
REMARK 465       A A  1885                                                      
REMARK 465       G A  1886                                                      
REMARK 465       G A  1887                                                      
REMARK 465       A A  1888                                                      
REMARK 465       G A  1889                                                      
REMARK 465       C A  1890                                                      
REMARK 465       G A  1891                                                      
REMARK 465       C A  1892                                                      
REMARK 465       U A  1893                                                      
REMARK 465       U A  1894                                                      
REMARK 465       A A  1895                                                      
REMARK 465       G A  1896                                                      
REMARK 465       C A  1897                                                      
REMARK 465       G A  1898                                                      
REMARK 465       U A  1899                                                      
REMARK 465       A A  1900                                                      
REMARK 465       A A  1901                                                      
REMARK 465       G A  1902                                                      
REMARK 465       C A  1903                                                      
REMARK 465       G A  1904                                                      
REMARK 465       A A  1905                                                      
REMARK 465       A A  1906                                                      
REMARK 465       G A  1907                                                      
REMARK 465       G A  1908                                                      
REMARK 465       U A  1909                                                      
REMARK 465       G A  1910                                                      
REMARK 465       C A  1911                                                      
REMARK 465       G A  1912                                                      
REMARK 465       A A  1913                                                      
REMARK 465       A A  1914                                                      
REMARK 465       U A  1915                                                      
REMARK 465       U A  1916                                                      
REMARK 465       G A  1917                                                      
REMARK 465       A A  1918                                                      
REMARK 465       A A  1919                                                      
REMARK 465       G A  1920                                                      
REMARK 465       C A  1921                                                      
REMARK 465       C A  1922                                                      
REMARK 465       C A  1923                                                      
REMARK 465       C A  1924                                                      
REMARK 465       A A  1925                                                      
REMARK 465       G A  1926                                                      
REMARK 465       U A  1927                                                      
REMARK 465       A A  1928                                                      
REMARK 465       A A  1929                                                      
REMARK 465       A A  1930                                                      
REMARK 465       C A  1931                                                      
REMARK 465       G A  1932                                                      
REMARK 465       G A  1933                                                      
REMARK 465       C A  1934                                                      
REMARK 465       G A  1935                                                      
REMARK 465       G A  1936                                                      
REMARK 465       C A  1937                                                      
REMARK 465       C A  1938                                                      
REMARK 465       G A  1939                                                      
REMARK 465       U A  1940                                                      
REMARK 465       A A  1941                                                      
REMARK 465       A A  1942                                                      
REMARK 465       C A  1943                                                      
REMARK 465       U A  1944                                                      
REMARK 465       A A  1945                                                      
REMARK 465       U A  1946                                                      
REMARK 465       A A  1947                                                      
REMARK 465       A A  1948                                                      
REMARK 465       C A  1949                                                      
REMARK 465       G A  1950                                                      
REMARK 465       G A  1951                                                      
REMARK 465       U A  1952                                                      
REMARK 465       C A  1953                                                      
REMARK 465       C A  1954                                                      
REMARK 465       U A  1955                                                      
REMARK 465       A A  1956                                                      
REMARK 465       A A  1957                                                      
REMARK 465       G A  1958                                                      
REMARK 465       G A  1959                                                      
REMARK 465       U A  1960                                                      
REMARK 465       A A  1961                                                      
REMARK 465       G A  1962                                                      
REMARK 465       C A  1963                                                      
REMARK 465       G A  1964                                                      
REMARK 465       A A  1965                                                      
REMARK 465       A A  1966                                                      
REMARK 465       A A  1967                                                      
REMARK 465       U A  1968                                                      
REMARK 465       U A  1969                                                      
REMARK 465       C A  1970                                                      
REMARK 465       C A  1971                                                      
REMARK 465       U A  1972                                                      
REMARK 465       U A  1973                                                      
REMARK 465       G A  1974                                                      
REMARK 465       U A  1975                                                      
REMARK 465       C A  1976                                                      
REMARK 465       G A  1977                                                      
REMARK 465       G A  1978                                                      
REMARK 465       G A  1979                                                      
REMARK 465       U A  1980                                                      
REMARK 465       A A  1981                                                      
REMARK 465       A A  1982                                                      
REMARK 465       G A  1983                                                      
REMARK 465       U A  1984                                                      
REMARK 465       U A  1985                                                      
REMARK 465       C A  1986                                                      
REMARK 465       C A  1987                                                      
REMARK 465       G A  1988                                                      
REMARK 465       A A  1989                                                      
REMARK 465       C A  1990                                                      
REMARK 465       C A  1991                                                      
REMARK 465       C A  1992                                                      
REMARK 465       G A  1993                                                      
REMARK 465       C A  1994                                                      
REMARK 465       A A  1995                                                      
REMARK 465       C A  1996                                                      
REMARK 465       G A  1997                                                      
REMARK 465       A A  1998                                                      
REMARK 465       A A  1999                                                      
REMARK 465       A A  2088                                                      
REMARK 465       A A  2089                                                      
REMARK 465       G A  2090                                                      
REMARK 465       G A  2139                                                      
REMARK 465       U A  2140                                                      
REMARK 465       A A  2141                                                      
REMARK 465       C A  2142                                                      
REMARK 465       A A  2143                                                      
REMARK 465       C A  2172                                                      
REMARK 465       G A  2173                                                      
REMARK 465       C A  2174                                                      
REMARK 465       C A  2175                                                      
REMARK 465       A A  2176                                                      
REMARK 465       G A  2194                                                      
REMARK 465       G A  2195                                                      
REMARK 465       U A  2196                                                      
REMARK 465       C A  2208                                                      
REMARK 465       U A  2209                                                      
REMARK 465       G A  2210                                                      
REMARK 465       G A  2211                                                      
REMARK 465       U A  2278                                                      
REMARK 465       G A  2279                                                      
REMARK 465       G A  2476                                                      
REMARK 465       A A  2477                                                      
REMARK 465       U A  2478                                                      
REMARK 465       A A  2479                                                      
REMARK 465       A A  2480                                                      
REMARK 465       C A  2481                                                      
REMARK 465       A A  2482                                                      
REMARK 465       G A  2483                                                      
REMARK 465       G A  2484                                                      
REMARK 465       C A  2485                                                      
REMARK 465       U A  2486                                                      
REMARK 465       U A  2487                                                      
REMARK 465       A A  2488                                                      
REMARK 465       U A  2489                                                      
REMARK 465       C A  2490                                                      
REMARK 465       U A  2491                                                      
REMARK 465       C A  2492                                                      
REMARK 465       C A  2493                                                      
REMARK 465       C A  2494                                                      
REMARK 465       C A  2495                                                      
REMARK 465       C A  2496                                                      
REMARK 465       A A  2497                                                      
REMARK 465       A A  2498                                                      
REMARK 465       G A  2499                                                      
REMARK 465       A A  2500                                                      
REMARK 465       G A  2501                                                      
REMARK 465       U A  2502                                                      
REMARK 465       C A  2503                                                      
REMARK 465       C A  2504                                                      
REMARK 465       A A  2505                                                      
REMARK 465       C A  2506                                                      
REMARK 465       A A  2507                                                      
REMARK 465       U A  2508                                                      
REMARK 465       C A  2509                                                      
REMARK 465       G A  2510                                                      
REMARK 465       A A  2511                                                      
REMARK 465       C A  2512                                                      
REMARK 465       G A  2513                                                      
REMARK 465       G A  2514                                                      
REMARK 465       G A  2515                                                      
REMARK 465       G A  2516                                                      
REMARK 465       A A  2517                                                      
REMARK 465       G A  2518                                                      
REMARK 465       G A  2519                                                      
REMARK 465       U A  2520                                                      
REMARK 465       U A  2521                                                      
REMARK 465       U A  2522                                                      
REMARK 465       G A  2523                                                      
REMARK 465       G A  2524                                                      
REMARK 465       C A  2525                                                      
REMARK 465       A A  2526                                                      
REMARK 465       C A  2527                                                      
REMARK 465       C A  2528                                                      
REMARK 465       U A  2529                                                      
REMARK 465       C A  2530                                                      
REMARK 465       G A  2531                                                      
REMARK 465       A A  2532                                                      
REMARK 465       U A  2533                                                      
REMARK 465       G A  2534                                                      
REMARK 465       U A  2535                                                      
REMARK 465       G A  2612                                                      
REMARK 465       U A  2613                                                      
REMARK 465       U A  2614                                                      
REMARK 465       C A  2926                                                      
REMARK 465       A A  2927                                                      
REMARK 465       U B     1                                                      
REMARK 465       U B     2                                                      
REMARK 465       G B   115                                                      
REMARK 465       C B   116                                                      
REMARK 465       A B   117                                                      
REMARK 465       A B   118                                                      
REMARK 465       G B   119                                                      
REMARK 465     MET C     1                                                      
REMARK 465     ALA C     2                                                      
REMARK 465     HIS C   232                                                      
REMARK 465     GLY C   233                                                      
REMARK 465     GLY C   234                                                      
REMARK 465     GLY C   235                                                      
REMARK 465     GLU C   236                                                      
REMARK 465     GLY C   237                                                      
REMARK 465     ARG C   238                                                      
REMARK 465     ALA C   239                                                      
REMARK 465     PRO C   240                                                      
REMARK 465     ILE C   241                                                      
REMARK 465     GLY C   242                                                      
REMARK 465     ARG C   243                                                      
REMARK 465     LYS C   244                                                      
REMARK 465     SER C   245                                                      
REMARK 465     LYS C   277                                                      
REMARK 465     MET D     1                                                      
REMARK 465     SER D   208                                                      
REMARK 465     LYS D   209                                                      
REMARK 465     MET E     1                                                      
REMARK 465     PRO E     2                                                      
REMARK 465     LYS E     3                                                      
REMARK 465     GLY E    11                                                      
REMARK 465     SER E    12                                                      
REMARK 465     THR E    13                                                      
REMARK 465     ALA E    14                                                      
REMARK 465     GLY E    15                                                      
REMARK 465     ASP E    16                                                      
REMARK 465     ALA E   207                                                      
REMARK 465     MET F     1                                                      
REMARK 465     GLY F    41                                                      
REMARK 465     ASP F    42                                                      
REMARK 465     ALA F    43                                                      
REMARK 465     VAL F    44                                                      
REMARK 465     GLN F    45                                                      
REMARK 465     ASN F    46                                                      
REMARK 465     ALA F    47                                                      
REMARK 465     LYS F    48                                                      
REMARK 465     ALA F    49                                                      
REMARK 465     ILE F    50                                                      
REMARK 465     ASP F    51                                                      
REMARK 465     LYS F    72                                                      
REMARK 465     SER F    73                                                      
REMARK 465     ILE F    74                                                      
REMARK 465     ALA F    75                                                      
REMARK 465     GLY F    76                                                      
REMARK 465     PHE F    77                                                      
REMARK 465     ARG F    78                                                      
REMARK 465     LEU F    79                                                      
REMARK 465     ARG F    80                                                      
REMARK 465     GLU F    81                                                      
REMARK 465     LYS F   133                                                      
REMARK 465     GLU F   134                                                      
REMARK 465     GLN F   135                                                      
REMARK 465     LEU F   136                                                      
REMARK 465     ILE F   137                                                      
REMARK 465     PHE F   138                                                      
REMARK 465     PRO F   139                                                      
REMARK 465     GLU F   140                                                      
REMARK 465     ILE F   141                                                      
REMARK 465     ASP F   142                                                      
REMARK 465     TYR F   143                                                      
REMARK 465     ASP F   144                                                      
REMARK 465     LYS F   145                                                      
REMARK 465     VAL F   146                                                      
REMARK 465     THR F   147                                                      
REMARK 465     LYS F   148                                                      
REMARK 465     GLN F   178                                                      
REMARK 465     LYS F   179                                                      
REMARK 465     MET G     1                                                      
REMARK 465     SER G     2                                                      
REMARK 465     ARG G     3                                                      
REMARK 465     VAL G     4                                                      
REMARK 465     GLY G     5                                                      
REMARK 465     LYS G     6                                                      
REMARK 465     LYS G     7                                                      
REMARK 465     LEU G     8                                                      
REMARK 465     LEU G     9                                                      
REMARK 465     GLU G    10                                                      
REMARK 465     ILE G    11                                                      
REMARK 465     PRO G    12                                                      
REMARK 465     SER G    13                                                      
REMARK 465     ASP G    14                                                      
REMARK 465     VAL G    15                                                      
REMARK 465     THR G    16                                                      
REMARK 465     VAL G    17                                                      
REMARK 465     THR G    18                                                      
REMARK 465     LEU G    19                                                      
REMARK 465     ASN G    20                                                      
REMARK 465     ASP G    21                                                      
REMARK 465     ASN G    22                                                      
REMARK 465     ASN G    23                                                      
REMARK 465     THR G    24                                                      
REMARK 465     VAL G    25                                                      
REMARK 465     ALA G    26                                                      
REMARK 465     VAL G    27                                                      
REMARK 465     LYS G    28                                                      
REMARK 465     GLY G    29                                                      
REMARK 465     PRO G    30                                                      
REMARK 465     LYS G    31                                                      
REMARK 465     GLY G    32                                                      
REMARK 465     GLU G    33                                                      
REMARK 465     LEU G    34                                                      
REMARK 465     THR G    35                                                      
REMARK 465     ARG G    36                                                      
REMARK 465     THR G    37                                                      
REMARK 465     PHE G    38                                                      
REMARK 465     HIS G    39                                                      
REMARK 465     PRO G    40                                                      
REMARK 465     ASP G    41                                                      
REMARK 465     MET G    42                                                      
REMARK 465     GLU G    43                                                      
REMARK 465     ILE G    44                                                      
REMARK 465     LYS G    45                                                      
REMARK 465     VAL G    46                                                      
REMARK 465     GLU G    47                                                      
REMARK 465     ASP G    48                                                      
REMARK 465     ASN G    49                                                      
REMARK 465     VAL G    50                                                      
REMARK 465     LEU G    51                                                      
REMARK 465     THR G    52                                                      
REMARK 465     VAL G    53                                                      
REMARK 465     ALA G    54                                                      
REMARK 465     ARG G    55                                                      
REMARK 465     PRO G    56                                                      
REMARK 465     SER G    57                                                      
REMARK 465     ASP G    58                                                      
REMARK 465     GLN G    59                                                      
REMARK 465     VAL G   169                                                      
REMARK 465     VAL G   170                                                      
REMARK 465     ARG G   171                                                      
REMARK 465     ARG G   172                                                      
REMARK 465     LYS G   173                                                      
REMARK 465     GLU G   174                                                      
REMARK 465     GLY G   175                                                      
REMARK 465     LYS G   176                                                      
REMARK 465     SER G   177                                                      
REMARK 465     ALA G   178                                                      
REMARK 465     LYS G   179                                                      
REMARK 465     MET J     1                                                      
REMARK 465     ARG J     2                                                      
REMARK 465     THR J     3                                                      
REMARK 465     GLY J   145                                                      
REMARK 465     ASN L    39                                                      
REMARK 465     ALA L    40                                                      
REMARK 465     ARG L    41                                                      
REMARK 465     SER L    42                                                      
REMARK 465     GLY L    43                                                      
REMARK 465     GLY L    44                                                      
REMARK 465     GLY L    45                                                      
REMARK 465     VAL L    46                                                      
REMARK 465     ARG L    47                                                      
REMARK 465     PRO L    48                                                      
REMARK 465     GLY L    49                                                      
REMARK 465     PHE L    50                                                      
REMARK 465     GLU L    51                                                      
REMARK 465     GLY L    52                                                      
REMARK 465     GLY L    53                                                      
REMARK 465     GLN L    54                                                      
REMARK 465     MET L    55                                                      
REMARK 465     PRO L    56                                                      
REMARK 465     LEU L    57                                                      
REMARK 465     PHE L    58                                                      
REMARK 465     GLN L    59                                                      
REMARK 465     ARG L    60                                                      
REMARK 465     LEU L    61                                                      
REMARK 465     PRO L    62                                                      
REMARK 465     MET N     1                                                      
REMARK 465     SER N     2                                                      
REMARK 465     MET O     1                                                      
REMARK 465     ILE O     2                                                      
REMARK 465     THR O     3                                                      
REMARK 465     LYS O     4                                                      
REMARK 465     THR O     5                                                      
REMARK 465     SER O     6                                                      
REMARK 465     LEU O    22                                                      
REMARK 465     SER O    23                                                      
REMARK 465     GLY O    24                                                      
REMARK 465     THR O    25                                                      
REMARK 465     ALA O    26                                                      
REMARK 465     GLU O    27                                                      
REMARK 465     ASP O    46                                                      
REMARK 465     ASP O    47                                                      
REMARK 465     VAL O    48                                                      
REMARK 465     ASN O    49                                                      
REMARK 465     GLY O    50                                                      
REMARK 465     GLY O    89                                                      
REMARK 465     ILE O    90                                                      
REMARK 465     SER O    91                                                      
REMARK 465     MET P     4                                                      
REMARK 465     LYS Q   119                                                      
REMARK 465     MET R     1                                                      
REMARK 465     ALA R   102                                                      
REMARK 465     MET S     1                                                      
REMARK 465     LYS S   111                                                      
REMARK 465     GLU S   112                                                      
REMARK 465     GLY S   113                                                      
REMARK 465     MET T     1                                                      
REMARK 465     LYS T     2                                                      
REMARK 465     PHE T    93                                                      
REMARK 465     GLU T    94                                                      
REMARK 465     ALA T    95                                                      
REMARK 465     MET U     1                                                      
REMARK 465     GLN U    49                                                      
REMARK 465     ALA U    50                                                      
REMARK 465     ASN U    51                                                      
REMARK 465     PRO U    52                                                      
REMARK 465     GLN U    53                                                      
REMARK 465     GLY U    54                                                      
REMARK 465     GLU U    86                                                      
REMARK 465     ASP U    87                                                      
REMARK 465     GLY U    88                                                      
REMARK 465     ASP U   102                                                      
REMARK 465     LYS U   103                                                      
REMARK 465     MET V     1                                                      
REMARK 465     LEU V     2                                                      
REMARK 465     ARG V     3                                                      
REMARK 465     LEU V     4                                                      
REMARK 465     ASP V     5                                                      
REMARK 465     LEU V     6                                                      
REMARK 465     GLN V     7                                                      
REMARK 465     PHE V     8                                                      
REMARK 465     PHE V     9                                                      
REMARK 465     ALA V    10                                                      
REMARK 465     GLY V    16                                                      
REMARK 465     SER V    17                                                      
REMARK 465     THR V    18                                                      
REMARK 465     LYS V    19                                                      
REMARK 465     ALA V    93                                                      
REMARK 465     GLN V    94                                                      
REMARK 465     MET Z     1                                                      
REMARK 465     MET b     1                                                      
REMARK 465     ASN b    55                                                      
REMARK 465     VAL b    56                                                      
REMARK 465     LYS b    57                                                      
REMARK 465     SER b    58                                                      
REMARK 465     ASN b    59                                                      
REMARK 465     LYS Y    66                                                      
REMARK 465     MET d     1                                                      
REMARK 465     MET W     1                                                      
REMARK 465     THR W     2                                                      
REMARK 465     ILE W     3                                                      
REMARK 465     GLN W     4                                                      
REMARK 465     LYS W    62                                                      
REMARK 465     ALA W    63                                                      
REMARK 465     ASP W    64                                                      
REMARK 465     ARG W   112                                                      
REMARK 465     ALA W   113                                                      
REMARK 465     LYS W   114                                                      
REMARK 465     GLY W   115                                                      
REMARK 465     VAL W   116                                                      
REMARK 465     LYS W   117                                                      
REMARK 465     SER W   157                                                      
REMARK 465     GLN W   158                                                      
REMARK 465     GLN W   159                                                      
REMARK 465     TRP W   160                                                      
REMARK 465     VAL W   161                                                      
REMARK 465     LYS W   162                                                      
REMARK 465     VAL W   163                                                      
REMARK 465     GLY W   164                                                      
REMARK 465     LYS W   165                                                      
REMARK 465     GLU W   166                                                      
REMARK 465     GLU W   181                                                      
REMARK 465     ASP W   182                                                      
REMARK 465     GLU W   183                                                      
REMARK 465     LEU W   184                                                      
REMARK 465     PRO W   280                                                      
REMARK 465     THR W   281                                                      
REMARK 465     MET W   282                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     MET W  10    CG   SD   CE                                        
REMARK 470     ARG W  14    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     THR W  18    OG1  CG2                                            
REMARK 470     GLU W  19    CG   CD   OE1  OE2                                  
REMARK 470     LYS W  20    CG   CD   CE   NZ                                   
REMARK 470     LEU W  21    CG   CD1  CD2                                       
REMARK 470     LYS W  22    CG   CD   CE   NZ                                   
REMARK 470     ASP W  46    CG   OD1  OD2                                       
REMARK 470     ASN W  50    CG   OD1  ND2                                       
REMARK 470     LYS W  59    CG   CD   CE   NZ                                   
REMARK 470     ARG W 119    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS W 133    CG   CD   CE   NZ                                   
REMARK 470     ARG W 151    CG   CD   NE   CZ   NH1  NH2                        
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   CD   LYS F    33     NH1  ARG F    92              1.15            
REMARK 500   O4'    A B    55     OE1  GLN F    27              1.15            
REMARK 500   OD2  ASP D    54     NH1  ARG D    78              1.18            
REMARK 500   OD1  ASP U    72     NE2  GLN U    99              1.24            
REMARK 500   O2     C B    41     CD   ARG F    92              1.33            
REMARK 500   O4     U A  2334     O    MET F    38              1.34            
REMARK 500   OD1  ASP U    72     CD   GLN U    99              1.35            
REMARK 500   O    ALA P   111     OE2  GLU P   115              1.41            
REMARK 500   CG   ASP U    72     NE2  GLN U    99              1.41            
REMARK 500   OP2    C A  2290     OG   SER V    24              1.42            
REMARK 500   O    PRO O    29     CG2  VAL O    93              1.45            
REMARK 500   O    GLY C   209     CD1  TRP C   213              1.49            
REMARK 500   N3     C B    40     OG1  THR F    90              1.51            
REMARK 500   N6     A A   673     CD1  LEU L   112              1.55            
REMARK 500   CD2  LEU F    57     CG2  VAL F    89              1.59            
REMARK 500   N2     G A  2126     O2     C A  2221              1.60            
REMARK 500   O2     C A  1527     N2     G A  1558              1.60            
REMARK 500   C4'    U B    54     CB   SER F    24              1.63            
REMARK 500   O2     C A  2687     N2     G A  2692              1.65            
REMARK 500   CE2  TYR F     8     CZ   TYR F    97              1.66            
REMARK 500   CE2  TYR F     8     OH   TYR F    97              1.68            
REMARK 500   CE2  PHE F   122     NH2  ARG F   167              1.69            
REMARK 500   O    GLY F   126     OG1  THR F   158              1.74            
REMARK 500   O2'    A A  2777     O    ALA G    64              1.77            
REMARK 500   NH1  ARG W    81     CG1  ILE W   103              1.79            
REMARK 500   C1'    A B    55     OE1  GLN F    27              1.80            
REMARK 500   O4'    U B    54     CB   SER F    24              1.82            
REMARK 500   NH2  ARG F     3     OD2  ASP F   101              1.82            
REMARK 500   O2'    A A  2777     CA   ALA G    64              1.83            
REMARK 500   O6     G A  2280     CB   LYS V    12              1.85            
REMARK 500   OD2  ASP U    72     NE2  GLN U    99              1.85            
REMARK 500   O6     G A   920     O6     G A   946              1.86            
REMARK 500   ND2  ASN W    58     CA   GLY W   132              1.88            
REMARK 500   OE1  GLN Q   108     ND2  ASN R    45              1.88            
REMARK 500   N    GLY U    82     O    VAL U    93              1.89            
REMARK 500   OP2    G A  2667     NH1  ARG D    84              1.90            
REMARK 500   O2'    C A  2342     ND2  ASN F    37              1.91            
REMARK 500   O5'    A A   342     NZ   LYS U    95              1.93            
REMARK 500   O2     C A  2823     N2     G A  2828              1.93            
REMARK 500   O2     C A  1861     N2     G A  2002              1.94            
REMARK 500   N2     G A  1397     C5     U A  1411              1.95            
REMARK 500   O2     C B    28     N2     G B    52              1.96            
REMARK 500   OP1    G A   341     O    GLY U    82              1.97            
REMARK 500   O6     G A  2552     N4     C A  2569              1.97            
REMARK 500   O2'    A A  2777     C    ALA G    64              1.98            
REMARK 500   CZ   PHE D    16     O    HIS P    80              1.98            
REMARK 500   CD   LYS P    94     NH2  ARG P   118              1.98            
REMARK 500   CG2  VAL W    67     OG   SER W   276              1.98            
REMARK 500   O    ARG U    80     CB   ALA U    94              1.98            
REMARK 500   OD1  ASN W    58     O    VAL W   131              1.99            
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS      98 CLOSE CONTACTS                                
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS                                      
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,2(A3,1X,A1,I4,A1,1X,A4,3X),1X,F6.3)               
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   RES CSSEQI ATM2   DEVIATION                     
REMARK 500      A A 179   N9      A A 179   C4     -0.040                       
REMARK 500      A A 630   N9      A A 630   C4     -0.037                       
REMARK 500      A A 830   N9      A A 830   C4     -0.037                       
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500      U A   8   N1  -  C2  -  O2  ANGL. DEV. =   4.6 DEGREES          
REMARK 500      U A   8   N3  -  C2  -  O2  ANGL. DEV. =  -5.5 DEGREES          
REMARK 500      U A   8   C2  -  N1  -  C1' ANGL. DEV. =   7.7 DEGREES          
REMARK 500      C A  31   C6  -  N1  -  C2  ANGL. DEV. =  -2.4 DEGREES          
REMARK 500      C A  31   N1  -  C2  -  O2  ANGL. DEV. =   4.0 DEGREES          
REMARK 500      U A  99   N1  -  C2  -  O2  ANGL. DEV. =   6.8 DEGREES          
REMARK 500      U A  99   N3  -  C2  -  O2  ANGL. DEV. =  -6.3 DEGREES          
REMARK 500      U A  99   C2  -  N1  -  C1' ANGL. DEV. =   9.0 DEGREES          
REMARK 500      C A 115   N1  -  C2  -  O2  ANGL. DEV. =   4.9 DEGREES          
REMARK 500      C A 115   N3  -  C2  -  O2  ANGL. DEV. =  -4.9 DEGREES          
REMARK 500      C A 115   C2  -  N1  -  C1' ANGL. DEV. =   7.0 DEGREES          
REMARK 500      A A 124   C3' -  O3' -  P   ANGL. DEV. =   7.3 DEGREES          
REMARK 500      C A 127   C6  -  N1  -  C2  ANGL. DEV. =  -2.6 DEGREES          
REMARK 500      C A 127   N1  -  C2  -  O2  ANGL. DEV. =   4.5 DEGREES          
REMARK 500      C A 127   N3  -  C2  -  O2  ANGL. DEV. =  -5.0 DEGREES          
REMARK 500      C A 134   N1  -  C2  -  O2  ANGL. DEV. =   3.7 DEGREES          
REMARK 500      C A 136   N1  -  C2  -  O2  ANGL. DEV. =   3.7 DEGREES          
REMARK 500      C A 158   N1  -  C2  -  O2  ANGL. DEV. =   4.3 DEGREES          
REMARK 500      C A 158   N3  -  C2  -  O2  ANGL. DEV. =  -4.3 DEGREES          
REMARK 500      C A 228   N1  -  C2  -  O2  ANGL. DEV. =   4.6 DEGREES          
REMARK 500      C A 228   N3  -  C2  -  O2  ANGL. DEV. =  -4.9 DEGREES          
REMARK 500      C A 241   N3  -  C2  -  O2  ANGL. DEV. =  -4.2 DEGREES          
REMARK 500      C A 272   N1  -  C2  -  O2  ANGL. DEV. =   3.8 DEGREES          
REMARK 500      C A 331   N1  -  C2  -  O2  ANGL. DEV. =   4.0 DEGREES          
REMARK 500      C A 359   N1  -  C2  -  O2  ANGL. DEV. =   3.9 DEGREES          
REMARK 500      C A 362   N1  -  C2  -  O2  ANGL. DEV. =   4.6 DEGREES          
REMARK 500      C A 362   N3  -  C2  -  O2  ANGL. DEV. =  -4.9 DEGREES          
REMARK 500      C A 363   N1  -  C2  -  O2  ANGL. DEV. =   4.0 DEGREES          
REMARK 500      C A 380   N1  -  C2  -  O2  ANGL. DEV. =   4.4 DEGREES          
REMARK 500      C A 380   N3  -  C2  -  O2  ANGL. DEV. =  -5.4 DEGREES          
REMARK 500      C A 392   N1  -  C2  -  O2  ANGL. DEV. =   5.3 DEGREES          
REMARK 500      C A 392   N3  -  C2  -  O2  ANGL. DEV. =  -4.8 DEGREES          
REMARK 500      C A 392   C2  -  N1  -  C1' ANGL. DEV. =   7.2 DEGREES          
REMARK 500      U A 394   N3  -  C2  -  O2  ANGL. DEV. =  -4.3 DEGREES          
REMARK 500      U A 397   N1  -  C2  -  O2  ANGL. DEV. =   4.3 DEGREES          
REMARK 500      G A 419   C3' -  O3' -  P   ANGL. DEV. =   7.3 DEGREES          
REMARK 500      C A 442   C6  -  N1  -  C2  ANGL. DEV. =  -2.8 DEGREES          
REMARK 500      C A 442   N1  -  C2  -  O2  ANGL. DEV. =   6.5 DEGREES          
REMARK 500      C A 442   N3  -  C2  -  O2  ANGL. DEV. =  -6.6 DEGREES          
REMARK 500      C A 442   C2  -  N1  -  C1' ANGL. DEV. =   9.0 DEGREES          
REMARK 500      C A 445   N1  -  C2  -  O2  ANGL. DEV. =   4.6 DEGREES          
REMARK 500      C A 466   N1  -  C2  -  O2  ANGL. DEV. =   3.9 DEGREES          
REMARK 500      C A 466   N3  -  C2  -  O2  ANGL. DEV. =  -4.6 DEGREES          
REMARK 500      C A 473   N1  -  C2  -  O2  ANGL. DEV. =   4.0 DEGREES          
REMARK 500      C A 473   N3  -  C2  -  O2  ANGL. DEV. =  -4.6 DEGREES          
REMARK 500      U A 478   N1  -  C2  -  O2  ANGL. DEV. =   4.6 DEGREES          
REMARK 500      U A 478   N3  -  C2  -  O2  ANGL. DEV. =  -4.7 DEGREES          
REMARK 500      C A 492   N1  -  C2  -  O2  ANGL. DEV. =   3.9 DEGREES          
REMARK 500      C A 508   C6  -  N1  -  C2  ANGL. DEV. =  -2.6 DEGREES          
REMARK 500      C A 508   N1  -  C2  -  O2  ANGL. DEV. =   4.1 DEGREES          
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     236 ANGLE DEVIATIONS.                             
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    ARG C  13       37.77    -96.72                                   
REMARK 500    THR C  25      -61.28    -99.77                                   
REMARK 500    HIS C  38       92.32    -68.45                                   
REMARK 500    LYS C  39      145.88    -36.65                                   
REMARK 500    ARG C  69       78.20     42.83                                   
REMARK 500    ALA C 122     -165.46    -77.49                                   
REMARK 500    GLU C 168     -169.05   -100.00                                   
REMARK 500    LYS C 170      -71.20    -63.84                                   
REMARK 500    ALA C 187       33.23    -93.79                                   
REMARK 500    LYS C 214      -73.17    -65.07                                   
REMARK 500    LYS C 263       56.66    -93.62                                   
REMARK 500    VAL C 271      -62.07   -125.04                                   
REMARK 500    ARG C 274       65.43     60.64                                   
REMARK 500    ILE D  10      -62.58   -120.72                                   
REMARK 500    GLU D  18       25.65     44.16                                   
REMARK 500    VAL D  27       74.03   -108.89                                   
REMARK 500    PRO D  32      104.84    -52.46                                   
REMARK 500    LYS D  56     -150.94    -92.12                                   
REMARK 500    GLU D  82     -168.27   -118.96                                   
REMARK 500    ALA D  90       56.34    -94.75                                   
REMARK 500    TYR D  91       59.40   -160.02                                   
REMARK 500    LYS D  98     -149.30   -118.16                                   
REMARK 500    ALA D 205      105.37    -54.26                                   
REMARK 500    VAL D 206       96.13    -57.07                                   
REMARK 500    ASN E   8       25.68   -141.05                                   
REMARK 500    GLN E   9       -5.29     65.11                                   
REMARK 500    PHE E  24       36.11    -99.43                                   
REMARK 500    SER E  43       -7.64     66.44                                   
REMARK 500    THR E  48       40.82   -103.52                                   
REMARK 500    LYS E  52     -165.23    -79.64                                   
REMARK 500    ARG E  58       93.70    -67.83                                   
REMARK 500    PRO E  81       14.82    -69.82                                   
REMARK 500    ASP E 128      -10.15     72.46                                   
REMARK 500    THR E 133     -166.65   -127.08                                   
REMARK 500    ASP E 158       -4.08   -142.13                                   
REMARK 500    ALA E 167       -1.82     62.33                                   
REMARK 500    GLU E 190       -5.73     62.00                                   
REMARK 500    LYS E 191      119.94   -165.43                                   
REMARK 500    LYS F  10       -9.26   -158.55                                   
REMARK 500    GLU F  11      -63.07   -121.35                                   
REMARK 500    VAL F  25      -56.98     56.86                                   
REMARK 500    GLU F  32     -112.07    -85.66                                   
REMARK 500    MET F  38      -91.34   -103.50                                   
REMARK 500    ILE F 104       57.04    -97.40                                   
REMARK 500    SER F 105      -19.06   -159.84                                   
REMARK 500    VAL F 106      -19.23   -145.65                                   
REMARK 500    ARG F 112      -72.21    -82.37                                   
REMARK 500    VAL F 117     -139.05   -143.25                                   
REMARK 500    LYS G  82      -56.50   -124.42                                   
REMARK 500    VAL G  93      -65.26    -90.34                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     137 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS                                         
REMARK 500                                                                      
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH          
REMARK 500 CIS AND TRANS CONFORMATION.  CIS BONDS, IF ANY, ARE LISTED           
REMARK 500 ON CISPEP RECORDS.  TRANS IS DEFINED AS 180 +/- 30 AND               
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.                                  
REMARK 500                                 MODEL     OMEGA                      
REMARK 500 ARG E   41     ALA E   42                  146.89                    
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 800                                                                      
REMARK 800 SITE                                                                 
REMARK 800 SITE_IDENTIFIER: AC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue GNP W 301                 
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: EMD-20435   RELATED DB: EMDB                             
REMARK 900 RELATED ID: 6PPF   RELATED DB: PDB                                   
REMARK 900 RELATED ID: EMD-20441   RELATED DB: EMDB                             
REMARK 900 RBGA+45SRBGA COMPLEX                                                 
DBREF1 6PPK A    1  2927  GB                   LN649259.1                       
DBREF2 6PPK A     723796434                       11709       14635             
DBREF1 6PPK B    1   119  GB                   CP015004.1                       
DBREF2 6PPK B     1012899741                      14700       14818             
DBREF1 6PPK C    1   277  UNP                  A0A063XCB6_BACIU                 
DBREF2 6PPK C     A0A063XCB6                          1         277             
DBREF1 6PPK D    1   209  UNP                  A0A063X745_BACIU                 
DBREF2 6PPK D     A0A063X745                          1         209             
DBREF1 6PPK E    1   207  UNP                  A0A063X8U6_BACIU                 
DBREF2 6PPK E     A0A063X8U6                          1         207             
DBREF1 6PPK F    1   179  UNP                  A0A063XB64_BACIU                 
DBREF2 6PPK F     A0A063XB64                          1         179             
DBREF1 6PPK G    1   179  UNP                  A0A063X781_BACIU                 
DBREF2 6PPK G     A0A063X781                          1         179             
DBREF1 6PPK J    1   145  UNP                  A0A063XCH0_BACIU                 
DBREF2 6PPK J     A0A063XCH0                          1         145             
DBREF1 6PPK K    1   122  UNP                  A0A063X754_BACIU                 
DBREF2 6PPK K     A0A063X754                          1         122             
DBREF1 6PPK L    1   146  UNP                  A0A063XCP1_BACIU                 
DBREF2 6PPK L     A0A063XCP1                          1         146             
DBREF1 6PPK N    1   120  UNP                  A0A063XCG5_BACIU                 
DBREF2 6PPK N     A0A063XCG5                          1         120             
DBREF  6PPK O    1   120  UNP    F5HRS9   F5HRS9_BACIU     1    120             
DBREF1 6PPK P    4   118  UNP                  A0A063XHU6_BACIU                 
DBREF2 6PPK P     A0A063XHU6                          1         115             
DBREF1 6PPK Q    2   119  UNP                  A0A063XFC1_BACIU                 
DBREF2 6PPK Q     A0A063XFC1                          2         119             
DBREF1 6PPK R    1   102  UNP                  A0A063XIS2_BACIU                 
DBREF2 6PPK R     A0A063XIS2                          1         102             
DBREF  6PPK S    1   113  UNP    F5HRT3   F5HRT3_BACIU     1    113             
DBREF1 6PPK T    1    95  UNP                  A0A063XB36_BACIU                 
DBREF2 6PPK T     A0A063XB36                          1          95             
DBREF  6PPK U    1   103  UNP    F5HRS7   F5HRS7_BACIU     1    103             
DBREF1 6PPK V    1    94  UNP                  A0A063XF22_BACIU                 
DBREF2 6PPK V     A0A063XF22                          1          94             
DBREF  6PPK Z    1    59  UNP    F5HRU6   F5HRU6_BACIU     1     59             
DBREF1 6PPK b    1    59  UNP                  A0A3A5I502_BACIU                 
DBREF2 6PPK b     A0A3A5I502                          1          59             
DBREF  6PPK Y    1    66  UNP    F5HRV8   F5HRV8_BACIU     1     66             
DBREF1 6PPK d    1    44  UNP                  A0A063XCT1_BACIU                 
DBREF2 6PPK d     A0A063XCT1                          1          44             
DBREF1 6PPK W    1   282  UNP                  A0A164SGC3_BACIU                 
DBREF2 6PPK W     A0A164SGC3                          1         282             
SEQRES   1 A 2927    G   G   U   U   A   A   G   U   U   A   G   A   A          
SEQRES   2 A 2927    A   G   G   G   C   G   C   A   C   G   G   U   G          
SEQRES   3 A 2927    G   A   U   G   C   C   U   U   G   G   C   A   C          
SEQRES   4 A 2927    U   A   G   G   A   G   C   C   G   A   U   G   A          
SEQRES   5 A 2927    A   G   G   A   C   G   G   G   A   C   G   A   A          
SEQRES   6 A 2927    C   A   C   C   G   A   U   A   U   G   C   U   U          
SEQRES   7 A 2927    C   G   G   G   G   A   G   C   U   G   U   A   A          
SEQRES   8 A 2927    G   C   A   A   G   C   U   U   U   G   A   U   C          
SEQRES   9 A 2927    C   G   G   A   G   A   U   U   U   C   C   G   A          
SEQRES  10 A 2927    A   U   G   G   G   G   A   A   A   C   C   C   A          
SEQRES  11 A 2927    C   C   A   C   U   C   G   U   A   A   U   G   G          
SEQRES  12 A 2927    A   G   U   G   G   U   A   U   C   C   A   U   A          
SEQRES  13 A 2927    U   C   U   G   A   A   U   U   C   A   U   A   G          
SEQRES  14 A 2927    G   A   U   A   U   G   A   G   A   A   G   G   C          
SEQRES  15 A 2927    A   G   A   C   C   C   G   G   G   G   A   A   C          
SEQRES  16 A 2927    U   G   A   A   A   C   A   U   C   U   A   A   G          
SEQRES  17 A 2927    U   A   C   C   C   G   G   A   G   G   A   A   G          
SEQRES  18 A 2927    A   G   A   A   A   G   C   A   A   A   U   G   C          
SEQRES  19 A 2927    G   A   U   U   C   C   C   U   G   A   G   U   A          
SEQRES  20 A 2927    G   C   G   G   C   G   A   G   C   G   A   A   A          
SEQRES  21 A 2927    C   G   G   G   A   U   C   A   G   C   C   C   A          
SEQRES  22 A 2927    A   A   C   C   A   A   G   A   G   G   C   U   U          
SEQRES  23 A 2927    G   C   C   U   C   U   U   G   G   G   G   U   U          
SEQRES  24 A 2927    G   U   A   G   G   A   C   A   C   U   C   U   G          
SEQRES  25 A 2927    U   A   C   G   G   A   G   U   U   A   C   A   A          
SEQRES  26 A 2927    A   G   G   A   A   C   G   A   G   G   U   A   G          
SEQRES  27 A 2927    A   U   G   A   A   G   A   G   G   U   C   U   G          
SEQRES  28 A 2927    G   A   A   A   G   G   C   C   C   G   C   C   A          
SEQRES  29 A 2927    U   A   G   G   A   G   G   U   A   A   C   A   G          
SEQRES  30 A 2927    C   C   C   U   G   U   A   G   U   C   A   A   A          
SEQRES  31 A 2927    A   C   U   U   C   G   U   U   C   U   C   U   C          
SEQRES  32 A 2927    C   U   G   A   G   U   G   G   A   U   C   C   U          
SEQRES  33 A 2927    G   A   G   U   A   C   G   G   C   G   G   A   A          
SEQRES  34 A 2927    C   A   C   G   U   G   A   A   A   U   U   C   C          
SEQRES  35 A 2927    G   U   C   G   G   A   A   U   C   C   G   G   G          
SEQRES  36 A 2927    A   G   G   A   C   C   A   U   C   U   C   C   C          
SEQRES  37 A 2927    A   A   G   G   C   U   A   A   A   U   A   C   U          
SEQRES  38 A 2927    C   C   C   U   A   G   U   G   A   C   C   G   A          
SEQRES  39 A 2927    U   A   G   U   G   A   A   C   C   A   G   U   A          
SEQRES  40 A 2927    C   C   G   U   G   A   G   G   G   A   A   A   G          
SEQRES  41 A 2927    G   U   G   A   A   A   A   G   C   A   C   C   C          
SEQRES  42 A 2927    C   G   G   A   A   G   G   G   G   A   G   U   G          
SEQRES  43 A 2927    A   A   A   G   A   G   A   U   C   C   U   G   A          
SEQRES  44 A 2927    A   A   C   C   G   U   G   U   G   C   C   U   A          
SEQRES  45 A 2927    C   A   A   G   U   A   G   U   C   A   G   A   G          
SEQRES  46 A 2927    C   C   C   G   U   U   A   A   C   G   G   G   U          
SEQRES  47 A 2927    G   A   U   G   G   C   G   U   G   C   C   U   U          
SEQRES  48 A 2927    U   U   G   U   A   G   A   A   U   G   A   A   C          
SEQRES  49 A 2927    C   G   G   C   G   A   G   U   U   A   C   G   A          
SEQRES  50 A 2927    U   C   U   C   G   U   G   C   A   A   G   G   U          
SEQRES  51 A 2927    U   A   A   G   C   A   G   A   A   G   A   U   G          
SEQRES  52 A 2927    C   G   G   A   G   C   C   G   C   A   G   C   G          
SEQRES  53 A 2927    A   A   A   G   C   G   A   G   U   C   U   G   A          
SEQRES  54 A 2927    A   U   A   G   G   G   C   G   C   A   U   G   A          
SEQRES  55 A 2927    G   U   A   C   G   U   G   G   U   C   G   U   A          
SEQRES  56 A 2927    G   A   C   C   C   G   A   A   A   C   C   A   G          
SEQRES  57 A 2927    G   U   G   A   U   C   U   A   C   C   C   A   U          
SEQRES  58 A 2927    G   U   C   C   A   G   G   G   U   G   A   A   G          
SEQRES  59 A 2927    U   U   C   A   G   G   U   A   A   C   A   C   U          
SEQRES  60 A 2927    G   A   A   U   G   G   A   G   G   C   C   C   G          
SEQRES  61 A 2927    A   A   C   C   C   A   C   G   C   A   C   G   U          
SEQRES  62 A 2927    U   G   A   A   A   A   G   U   G   C   G   G   G          
SEQRES  63 A 2927    G   A   U   G   A   G   G   U   G   U   G   G   G          
SEQRES  64 A 2927    U   A   G   G   G   G   U   G   A   A   A   U   G          
SEQRES  65 A 2927    C   C   A   A   U   C   G   A   A   C   C   U   G          
SEQRES  66 A 2927    G   A   G   A   U   A   G   C   U   G   G   U   U          
SEQRES  67 A 2927    C   U   C   U   C   C   G   A   A   A   U   A   G          
SEQRES  68 A 2927    C   U   U   U   A   G   G   G   C   U   A   G   C          
SEQRES  69 A 2927    C   U   C   A   A   G   G   U   A   A   G   A   G          
SEQRES  70 A 2927    U   C   U   U   G   G   A   G   G   U   A   G   A          
SEQRES  71 A 2927    G   C   A   C   U   G   A   U   U   G   G   A   C          
SEQRES  72 A 2927    U   A   G   G   G   G   C   C   C   C   U   A   C          
SEQRES  73 A 2927    C   G   G   G   U   U   A   C   C   G   A   A   U          
SEQRES  74 A 2927    U   C   A   G   U   C   A   A   A   C   U   C   C          
SEQRES  75 A 2927    G   A   A   U   G   C   C   A   A   U   G   A   C          
SEQRES  76 A 2927    U   U   A   U   C   C   U   U   G   G   G   A   G          
SEQRES  77 A 2927    U   C   A   G   A   C   U   G   C   G   A   G   U          
SEQRES  78 A 2927    G   A   U   A   A   G   A   U   C   C   G   U   A          
SEQRES  79 A 2927    G   U   C   G   A   A   A   G   G   G   A   A   A          
SEQRES  80 A 2927    C   A   G   C   C   C   A   G   A   C   C   G   C          
SEQRES  81 A 2927    C   A   G   C   U   A   A   G   G   U   C   C   C          
SEQRES  82 A 2927    A   A   A   G   U   A   U   A   C   G   U   U   A          
SEQRES  83 A 2927    A   G   U   G   G   A   A   A   A   G   G   A   U          
SEQRES  84 A 2927    G   U   G   G   A   G   U   U   G   C   U   U   A          
SEQRES  85 A 2927    G   A   C   A   A   C   C   A   G   G   A   U   G          
SEQRES  86 A 2927    U   U   G   G   C   U   U   A   G   A   A   G   C          
SEQRES  87 A 2927    A   G   C   C   A   C   C   A   U   U   U   A   A          
SEQRES  88 A 2927    A   G   A   G   U   G   C   G   U   A   A   U   A          
SEQRES  89 A 2927    G   C   U   C   A   C   U   G   G   U   C   G   A          
SEQRES  90 A 2927    G   U   G   A   C   U   C   U   G   C   G   C   C          
SEQRES  91 A 2927    G   A   A   A   A   U   G   U   A   C   C   G   G          
SEQRES  92 A 2927    G   G   C   U   A   A   A   C   G   U   A   U   C          
SEQRES  93 A 2927    A   C   C   G   A   A   G   C   U   G   C   G   G          
SEQRES  94 A 2927    A   C   U   G   U   U   C   U   U   C   G   A   A          
SEQRES  95 A 2927    C   A   G   U   G   G   U   A   G   G   A   G   A          
SEQRES  96 A 2927    G   C   G   U   U   C   U   A   A   G   G   G   C          
SEQRES  97 A 2927    U   G   U   G   A   A   G   C   C   A   G   A   C          
SEQRES  98 A 2927    C   G   G   A   A   G   G   A   C   U   G   G   U          
SEQRES  99 A 2927    G   G   A   G   C   G   C   U   U   A   G   A   A          
SEQRES 100 A 2927    G   U   G   A   G   A   A   U   G   C   C   G   G          
SEQRES 101 A 2927    U   A   U   G   A   G   U   A   G   C   G   A   A          
SEQRES 102 A 2927    A   G   A   G   G   G   G   U   G   A   G   A   A          
SEQRES 103 A 2927    U   C   C   C   C   U   C   C   A   C   C   G   A          
SEQRES 104 A 2927    A   U   G   C   C   U   A   A   G   G   U   U   U          
SEQRES 105 A 2927    C   C   U   G   A   G   G   A   A   G   G   C   U          
SEQRES 106 A 2927    C   G   U   C   C   G   C   U   C   A   G   G   G          
SEQRES 107 A 2927    U   U   A   G   U   C   G   G   G   A   C   C   U          
SEQRES 108 A 2927    A   A   G   C   C   G   A   G   G   C   C   G   A          
SEQRES 109 A 2927    A   A   G   G   C   G   U   A   G   G   C   G   A          
SEQRES 110 A 2927    U   G   G   A   C   A   A   C   A   G   G   U   U          
SEQRES 111 A 2927    G   A   U   A   U   U   C   C   U   G   U   A   C          
SEQRES 112 A 2927    C   A   C   C   U   C   C   U   C   A   C   C   A          
SEQRES 113 A 2927    U   U   U   G   A   G   C   A   A   U   G   G   G          
SEQRES 114 A 2927    G   G   G   A   C   G   C   A   G   G   A   G   G          
SEQRES 115 A 2927    A   U   A   G   G   G   U   A   A   G   C   G   C          
SEQRES 116 A 2927    G   G   U   A   U   U   G   G   A   U   A   U   C          
SEQRES 117 A 2927    C   G   C   G   U   C   C   A   A   G   C   A   G          
SEQRES 118 A 2927    U   U   A   G   G   C   U   G   G   G   A   A   A          
SEQRES 119 A 2927    U   A   G   G   C   A   A   A   U   C   C   G   U          
SEQRES 120 A 2927    U   U   C   C   C   A   U   A   A   G   G   C   U          
SEQRES 121 A 2927    G   A   G   C   U   G   U   G   A   U   G   G   C          
SEQRES 122 A 2927    G   A   G   C   G   A   A   A   U   A   U   A   G          
SEQRES 123 A 2927    U   A   G   C   G   A   A   G   U   U   C   C   U          
SEQRES 124 A 2927    G   A   U   U   C   C   A   C   A   C   U   G   C          
SEQRES 125 A 2927    C   A   A   G   A   A   A   A   G   C   C   U   C          
SEQRES 126 A 2927    U   A   G   C   G   A   G   G   U   G   A   G   A          
SEQRES 127 A 2927    G   G   U   G   C   C   C   G   U   A   C   C   G          
SEQRES 128 A 2927    C   A   A   A   C   C   G   A   C   A   C   A   G          
SEQRES 129 A 2927    G   U   A   G   G   C   G   A   G   G   A   G   A          
SEQRES 130 A 2927    G   A   A   U   C   C   U   A   A   G   G   U   G          
SEQRES 131 A 2927    A   U   C   G   A   G   A   G   A   A   C   U   C          
SEQRES 132 A 2927    U   C   G   U   U   A   A   G   G   A   A   C   U          
SEQRES 133 A 2927    C   G   G   C   A   A   A   A   U   G   A   C   C          
SEQRES 134 A 2927    C   C   G   U   A   A   C   U   U   C   G   G   G          
SEQRES 135 A 2927    A   G   A   A   G   G   G   G   U   G   C   U   C          
SEQRES 136 A 2927    U   G   U   U   A   G   G   G   U   G   C   A   A          
SEQRES 137 A 2927    G   C   C   C   G   A   G   A   G   A   G   C   C          
SEQRES 138 A 2927    G   C   A   G   U   G   A   A   U   A   G   G   C          
SEQRES 139 A 2927    C   C   A   G   G   C   G   A   C   U   G   U   U          
SEQRES 140 A 2927    U   A   G   C   A   A   A   A   A   C   A   C   A          
SEQRES 141 A 2927    G   G   U   C   U   C   U   G   C   G   A   A   G          
SEQRES 142 A 2927    C   C   G   U   A   A   G   G   C   G   A   A   G          
SEQRES 143 A 2927    U   A   U   A   G   G   G   G   C   U   G   A   C          
SEQRES 144 A 2927    G   C   C   U   G   C   C   C   G   G   U   G   C          
SEQRES 145 A 2927    U   G   G   A   A   G   G   U   U   A   A   G   A          
SEQRES 146 A 2927    G   G   A   G   C   G   C   U   U   A   G   C   G          
SEQRES 147 A 2927    U   A   A   G   C   G   A   A   G   G   U   G   C          
SEQRES 148 A 2927    G   A   A   U   U   G   A   A   G   C   C   C   C          
SEQRES 149 A 2927    A   G   U   A   A   A   C   G   G   C   G   G   C          
SEQRES 150 A 2927    C   G   U   A   A   C   U   A   U   A   A   C   G          
SEQRES 151 A 2927    G   U   C   C   U   A   A   G   G   U   A   G   C          
SEQRES 152 A 2927    G   A   A   A   U   U   C   C   U   U   G   U   C          
SEQRES 153 A 2927    G   G   G   U   A   A   G   U   U   C   C   G   A          
SEQRES 154 A 2927    C   C   C   G   C   A   C   G   A   A   A   G   G          
SEQRES 155 A 2927    C   G   C   A   A   C   G   A   U   C   U   G   G          
SEQRES 156 A 2927    G   C   A   C   U   G   U   C   U   C   A   A   C          
SEQRES 157 A 2927    G   A   G   A   G   A   C   U   C   G   G   U   G          
SEQRES 158 A 2927    A   A   A   U   U   A   U   A   G   U   A   C   C          
SEQRES 159 A 2927    U   G   U   G   A   A   G   A   U   G   C   A   G          
SEQRES 160 A 2927    G   U   U   A   C   C   C   G   C   G   A   C   A          
SEQRES 161 A 2927    G   G   A   C   G   G   A   A   A   G   A   C   C          
SEQRES 162 A 2927    C   C   G   U   G   G   A   G   C   U   U   U   A          
SEQRES 163 A 2927    C   U   G   C   A   G   C   C   U   G   A   U   A          
SEQRES 164 A 2927    U   U   G   A   A   U   G   U   U   G   G   U   A          
SEQRES 165 A 2927    C   A   G   C   U   U   G   U   A   C   A   G   G          
SEQRES 166 A 2927    A   U   A   G   G   U   A   G   G   A   G   C   C          
SEQRES 167 A 2927    U   U   G   G   A   A   A   C   C   G   G   A   G          
SEQRES 168 A 2927    C   G   C   C   A   G   C   U   U   C   G   G   U          
SEQRES 169 A 2927    G   G   A   G   G   C   A   U   C   G   G   U   G          
SEQRES 170 A 2927    G   G   A   U   A   C   U   A   C   C   C   U   G          
SEQRES 171 A 2927    G   C   U   G   U   A   U   U   G   A   C   C   U          
SEQRES 172 A 2927    U   C   U   A   A   C   C   C   G   C   C   G   C          
SEQRES 173 A 2927    C   C   U   U   A   U   C   G   G   G   C   G   G          
SEQRES 174 A 2927    G   G   A   G   A   C   A   G   U   G   U   C   A          
SEQRES 175 A 2927    G   G   U   G   G   G   C   A   G   U   U   U   G          
SEQRES 176 A 2927    A   C   U   G   G   G   G   C   G   G   U   C   G          
SEQRES 177 A 2927    C   C   U   C   C   U   A   A   A   A   G   G   U          
SEQRES 178 A 2927    A   A   C   G   G   A   G   G   C   G   C   C   C          
SEQRES 179 A 2927    A   A   A   G   G   U   U   C   C   C   U   C   A          
SEQRES 180 A 2927    G   A   A   U   G   G   U   U   G   G   A   A   A          
SEQRES 181 A 2927    U   C   A   U   U   C   G   C   A   G   A   G   U          
SEQRES 182 A 2927    G   U   A   A   A   G   G   C   A   C   A   A   G          
SEQRES 183 A 2927    G   G   A   G   C   U   U   G   A   C   U   G   C          
SEQRES 184 A 2927    G   A   G   A   C   C   U   A   C   A   A   G   U          
SEQRES 185 A 2927    C   G   A   G   C   A   G   G   G   A   C   G   A          
SEQRES 186 A 2927    A   A   G   U   C   G   G   G   C   U   U   A   G          
SEQRES 187 A 2927    U   G   A   U   C   C   G   G   U   G   G   U   U          
SEQRES 188 A 2927    C   C   G   C   A   U   G   G   A   A   G   G   G          
SEQRES 189 A 2927    C   C   A   U   C   G   C   U   C   A   A   C   G          
SEQRES 190 A 2927    G   A   U   A   A   A   A   G   C   U   A   C   C          
SEQRES 191 A 2927    C   C   G   G   G   G   A   U   A   A   C   A   G          
SEQRES 192 A 2927    G   C   U   U   A   U   C   U   C   C   C   C   C          
SEQRES 193 A 2927    A   A   G   A   G   U   C   C   A   C   A   U   C          
SEQRES 194 A 2927    G   A   C   G   G   G   G   A   G   G   U   U   U          
SEQRES 195 A 2927    G   G   C   A   C   C   U   C   G   A   U   G   U          
SEQRES 196 A 2927    C   G   G   C   U   C   A   U   C   G   C   A   U          
SEQRES 197 A 2927    C   C   U   G   G   G   G   C   U   G   U   A   G          
SEQRES 198 A 2927    U   C   G   G   U   C   C   C   A   A   G   G   G          
SEQRES 199 A 2927    U   U   G   G   G   C   U   G   U   U   C   G   C          
SEQRES 200 A 2927    C   C   A   U   U   A   A   A   G   C   G   G   U          
SEQRES 201 A 2927    A   C   G   C   G   A   G   C   U   G   G   G   U          
SEQRES 202 A 2927    U   C   A   G   A   A   C   G   U   C   G   U   G          
SEQRES 203 A 2927    A   G   A   C   A   G   U   U   C   G   G   U   C          
SEQRES 204 A 2927    C   C   U   A   U   C   C   G   U   C   G   C   G          
SEQRES 205 A 2927    G   G   C   G   C   A   G   G   A   A   A   U   U          
SEQRES 206 A 2927    U   G   A   G   A   G   G   A   G   C   U   G   U          
SEQRES 207 A 2927    C   C   U   U   A   G   U   A   C   G   A   G   A          
SEQRES 208 A 2927    G   G   A   C   C   G   G   G   A   U   G   G   A          
SEQRES 209 A 2927    C   G   C   A   C   C   G   C   U   G   G   U   G          
SEQRES 210 A 2927    U   A   C   C   A   G   U   U   G   U   U   C   U          
SEQRES 211 A 2927    G   C   C   A   A   G   G   G   C   A   U   C   G          
SEQRES 212 A 2927    C   U   G   G   G   U   A   G   C   U   A   U   G          
SEQRES 213 A 2927    U   G   C   G   G   A   C   G   G   G   A   U   A          
SEQRES 214 A 2927    A   G   U   G   C   U   G   A   A   A   G   C   A          
SEQRES 215 A 2927    U   C   U   A   A   G   C   A   U   G   A   A   G          
SEQRES 216 A 2927    C   C   C   C   C   C   U   C   A   A   G   A   U          
SEQRES 217 A 2927    G   A   G   A   U   U   U   C   C   C   A   U   U          
SEQRES 218 A 2927    C   C   G   C   A   A   G   G   A   A   G   U   A          
SEQRES 219 A 2927    A   G   A   U   C   C   C   U   G   A   A   A   G          
SEQRES 220 A 2927    A   U   G   A   U   C   A   G   G   U   U   G   A          
SEQRES 221 A 2927    U   A   G   G   U   C   U   G   A   G   G   U   G          
SEQRES 222 A 2927    G   A   A   G   U   G   U   G   G   C   G   A   C          
SEQRES 223 A 2927    A   C   A   U   G   G   A   G   C   U   G   A   C          
SEQRES 224 A 2927    A   G   A   U   A   C   U   A   A   U   C   G   A          
SEQRES 225 A 2927    U   C   G   A   G   G   A   C   U   U   A   A   C          
SEQRES 226 A 2927    C   A                                                      
SEQRES   1 B  119    U   U   U   G   G   U   G   G   C   G   A   U   A          
SEQRES   2 B  119    G   C   G   A   A   G   A   G   G   U   C   A   C          
SEQRES   3 B  119    A   C   C   C   G   U   U   C   C   C   A   U   A          
SEQRES   4 B  119    C   C   G   A   A   C   A   C   G   G   A   A   G          
SEQRES   5 B  119    U   U   A   A   G   C   U   C   U   U   C   A   G          
SEQRES   6 B  119    C   G   C   C   G   A   U   G   G   U   A   G   U          
SEQRES   7 B  119    C   G   G   G   G   G   U   U   U   C   C   C   C          
SEQRES   8 B  119    C   U   G   U   G   A   G   A   G   U   A   G   G          
SEQRES   9 B  119    A   C   G   C   C   G   C   C   A   A   G   C   A          
SEQRES  10 B  119    A   G                                                      
SEQRES   1 C  277  MET ALA ILE LYS LYS TYR LYS PRO THR SER ASN GLY ARG          
SEQRES   2 C  277  ARG GLY MET THR THR SER ASP PHE ALA GLU ILE THR THR          
SEQRES   3 C  277  ASP LYS PRO GLU LYS SER LEU LEU ALA PRO LEU HIS LYS          
SEQRES   4 C  277  LYS GLY GLY ARG ASN ASN GLN GLY LYS LEU THR VAL ARG          
SEQRES   5 C  277  HIS GLN GLY GLY GLY HIS LYS ARG GLN TYR ARG VAL ILE          
SEQRES   6 C  277  ASP PHE LYS ARG ASP LYS ASP GLY ILE PRO GLY ARG VAL          
SEQRES   7 C  277  ALA THR VAL GLU TYR ASP PRO ASN ARG SER ALA ASN ILE          
SEQRES   8 C  277  ALA LEU ILE ASN TYR ALA ASP GLY GLU LYS ARG TYR ILE          
SEQRES   9 C  277  LEU ALA PRO LYS GLY ILE GLN VAL GLY THR GLU ILE MET          
SEQRES  10 C  277  SER GLY PRO GLU ALA ASP ILE LYS VAL GLY ASN ALA LEU          
SEQRES  11 C  277  PRO LEU ILE ASN ILE PRO VAL GLY THR VAL VAL HIS ASN          
SEQRES  12 C  277  ILE GLU LEU LYS PRO GLY LYS GLY GLY GLN LEU VAL ARG          
SEQRES  13 C  277  SER ALA GLY THR SER ALA GLN VAL LEU GLY LYS GLU GLY          
SEQRES  14 C  277  LYS TYR VAL LEU VAL ARG LEU ASN SER GLY GLU VAL ARG          
SEQRES  15 C  277  MET ILE LEU SER ALA CYS ARG ALA SER ILE GLY GLN VAL          
SEQRES  16 C  277  GLY ASN GLU GLN HIS GLU LEU ILE ASN ILE GLY LYS ALA          
SEQRES  17 C  277  GLY ARG SER ARG TRP LYS GLY ILE ARG PRO THR VAL ARG          
SEQRES  18 C  277  GLY SER VAL MET ASN PRO ASN ASP HIS PRO HIS GLY GLY          
SEQRES  19 C  277  GLY GLU GLY ARG ALA PRO ILE GLY ARG LYS SER PRO MET          
SEQRES  20 C  277  SER PRO TRP GLY LYS PRO THR LEU GLY PHE LYS THR ARG          
SEQRES  21 C  277  LYS LYS LYS ASN LYS SER ASP LYS PHE ILE VAL ARG ARG          
SEQRES  22 C  277  ARG LYS ASN LYS                                              
SEQRES   1 D  209  MET THR LYS GLY ILE LEU GLY ARG LYS ILE GLY MET THR          
SEQRES   2 D  209  GLN VAL PHE ALA GLU ASN GLY ASP LEU ILE PRO VAL THR          
SEQRES   3 D  209  VAL ILE GLU ALA ALA PRO ASN VAL VAL LEU GLN LYS LYS          
SEQRES   4 D  209  THR ALA GLU ASN ASP GLY TYR GLU ALA ILE GLN LEU GLY          
SEQRES   5 D  209  PHE ASP ASP LYS ARG GLU LYS LEU SER ASN LYS PRO GLU          
SEQRES   6 D  209  LYS GLY HIS VAL ALA LYS ALA GLU THR ALA PRO LYS ARG          
SEQRES   7 D  209  PHE VAL LYS GLU LEU ARG GLY VAL GLU MET ASP ALA TYR          
SEQRES   8 D  209  GLU VAL GLY GLN GLU VAL LYS VAL GLU ILE PHE SER ALA          
SEQRES   9 D  209  GLY GLU ILE VAL ASP VAL THR GLY VAL SER LYS GLY LYS          
SEQRES  10 D  209  GLY PHE GLN GLY ALA ILE LYS ARG HIS GLY GLN SER ARG          
SEQRES  11 D  209  GLY PRO MET SER HIS GLY SER ARG TYR HIS ARG ARG PRO          
SEQRES  12 D  209  GLY SER MET GLY PRO VAL ASP PRO ASN ARG VAL PHE LYS          
SEQRES  13 D  209  GLY LYS LEU LEU PRO GLY ARG MET GLY GLY GLU GLN ILE          
SEQRES  14 D  209  THR VAL GLN ASN LEU GLU ILE VAL LYS VAL ASP ALA GLU          
SEQRES  15 D  209  ARG ASN LEU LEU LEU ILE LYS GLY ASN VAL PRO GLY ALA          
SEQRES  16 D  209  LYS LYS SER LEU ILE THR VAL LYS SER ALA VAL LYS SER          
SEQRES  17 D  209  LYS                                                          
SEQRES   1 E  207  MET PRO LYS VAL ALA LEU TYR ASN GLN ASN GLY SER THR          
SEQRES   2 E  207  ALA GLY ASP ILE GLU LEU ASN ALA SER VAL PHE GLY ILE          
SEQRES   3 E  207  GLU PRO ASN GLU SER VAL VAL PHE ASP ALA ILE LEU MET          
SEQRES   4 E  207  GLN ARG ALA SER LEU ARG GLN GLY THR HIS LYS VAL LYS          
SEQRES   5 E  207  ASN ARG SER GLU VAL ARG GLY GLY GLY ARG LYS PRO TRP          
SEQRES   6 E  207  ARG GLN LYS GLY THR GLY ARG ALA ARG GLN GLY SER ILE          
SEQRES   7 E  207  ARG SER PRO GLN TRP ARG GLY GLY GLY VAL VAL PHE GLY          
SEQRES   8 E  207  PRO THR PRO ARG SER TYR SER TYR LYS LEU PRO LYS LYS          
SEQRES   9 E  207  VAL ARG ARG LEU ALA ILE LYS SER VAL LEU SER SER LYS          
SEQRES  10 E  207  VAL ILE ASP ASN ASN ILE ILE VAL LEU GLU ASP LEU THR          
SEQRES  11 E  207  LEU ASP THR ALA LYS THR LYS GLU MET ALA ALA ILE LEU          
SEQRES  12 E  207  LYS GLY LEU SER VAL GLU LYS LYS ALA LEU ILE VAL THR          
SEQRES  13 E  207  ALA ASP ALA ASN GLU ALA VAL ALA LEU SER ALA ARG ASN          
SEQRES  14 E  207  ILE PRO GLY VAL THR VAL VAL GLU ALA ASN GLY ILE ASN          
SEQRES  15 E  207  VAL LEU ASP VAL VAL ASN HIS GLU LYS LEU LEU ILE THR          
SEQRES  16 E  207  LYS ALA ALA VAL GLU LYS VAL GLU GLU VAL LEU ALA              
SEQRES   1 F  179  MET ASN ARG LEU LYS GLU LYS TYR ASN LYS GLU ILE ALA          
SEQRES   2 F  179  PRO ALA LEU MET THR LYS PHE ASN TYR ASP SER VAL MET          
SEQRES   3 F  179  GLN VAL PRO LYS ILE GLU LYS ILE VAL ILE ASN MET GLY          
SEQRES   4 F  179  VAL GLY ASP ALA VAL GLN ASN ALA LYS ALA ILE ASP SER          
SEQRES   5 F  179  ALA VAL GLU GLU LEU THR PHE ILE ALA GLY GLN LYS PRO          
SEQRES   6 F  179  VAL VAL THR ARG ALA LYS LYS SER ILE ALA GLY PHE ARG          
SEQRES   7 F  179  LEU ARG GLU GLY MET PRO ILE GLY ALA LYS VAL THR LEU          
SEQRES   8 F  179  ARG GLY GLU ARG MET TYR ASP PHE LEU ASP LYS LEU ILE          
SEQRES   9 F  179  SER VAL SER LEU PRO ARG VAL ARG ASP PHE ARG GLY VAL          
SEQRES  10 F  179  SER LYS LYS SER PHE ASP GLY ARG GLY ASN TYR THR LEU          
SEQRES  11 F  179  GLY ILE LYS GLU GLN LEU ILE PHE PRO GLU ILE ASP TYR          
SEQRES  12 F  179  ASP LYS VAL THR LYS VAL ARG GLY MET ASP ILE VAL ILE          
SEQRES  13 F  179  VAL THR THR ALA ASN THR ASP GLU GLU ALA ARG GLU LEU          
SEQRES  14 F  179  LEU THR GLN VAL GLY MET PRO PHE GLN LYS                      
SEQRES   1 G  179  MET SER ARG VAL GLY LYS LYS LEU LEU GLU ILE PRO SER          
SEQRES   2 G  179  ASP VAL THR VAL THR LEU ASN ASP ASN ASN THR VAL ALA          
SEQRES   3 G  179  VAL LYS GLY PRO LYS GLY GLU LEU THR ARG THR PHE HIS          
SEQRES   4 G  179  PRO ASP MET GLU ILE LYS VAL GLU ASP ASN VAL LEU THR          
SEQRES   5 G  179  VAL ALA ARG PRO SER ASP GLN LYS GLU HIS ARG ALA LEU          
SEQRES   6 G  179  HIS GLY THR THR ARG SER LEU LEU GLY ASN MET VAL GLU          
SEQRES   7 G  179  GLY VAL SER LYS GLY PHE GLU ARG GLY LEU GLU LEU VAL          
SEQRES   8 G  179  GLY VAL GLY TYR ARG ALA SER LYS SER GLY ASN LYS LEU          
SEQRES   9 G  179  VAL LEU ASN VAL GLY TYR SER HIS PRO VAL GLU ILE VAL          
SEQRES  10 G  179  PRO GLU GLU GLY ILE GLU ILE GLU VAL PRO SER GLN THR          
SEQRES  11 G  179  LYS VAL VAL VAL LYS GLY THR ASP LYS GLU ARG VAL GLY          
SEQRES  12 G  179  ALA ILE ALA ALA ASN ILE ARG ALA VAL ARG SER PRO GLU          
SEQRES  13 G  179  PRO TYR LYS GLY LYS GLY ILE ARG TYR GLU GLY GLU VAL          
SEQRES  14 G  179  VAL ARG ARG LYS GLU GLY LYS SER ALA LYS                      
SEQRES   1 J  145  MET ARG THR THR PRO MET ALA ASN ALA SER THR ILE GLU          
SEQRES   2 J  145  ARG LYS TRP LEU VAL VAL ASP ALA ALA GLY LYS THR LEU          
SEQRES   3 J  145  GLY ARG LEU SER SER GLU VAL ALA ALA ILE LEU ARG GLY          
SEQRES   4 J  145  LYS HIS LYS PRO THR TYR THR PRO HIS VAL ASP THR GLY          
SEQRES   5 J  145  ASP HIS VAL ILE ILE ILE ASN ALA GLU LYS ILE GLU LEU          
SEQRES   6 J  145  THR GLY LYS LYS LEU THR ASP LYS ILE TYR TYR ARG HIS          
SEQRES   7 J  145  THR GLN HIS PRO GLY GLY LEU LYS SER ARG THR ALA LEU          
SEQRES   8 J  145  GLU MET ARG THR ASN TYR PRO GLU LYS MET LEU GLU LEU          
SEQRES   9 J  145  ALA ILE LYS GLY MET LEU PRO LYS GLY SER LEU GLY ARG          
SEQRES  10 J  145  GLN MET PHE LYS LYS LEU ASN VAL TYR ARG GLY SER GLU          
SEQRES  11 J  145  HIS PRO HIS GLU ALA GLN LYS PRO GLU VAL TYR GLU LEU          
SEQRES  12 J  145  ARG GLY                                                      
SEQRES   1 K  122  MET ILE GLN GLN GLU THR ARG LEU LYS VAL ALA ASP ASN          
SEQRES   2 K  122  SER GLY ALA ARG GLU VAL LEU THR ILE LYS VAL LEU GLY          
SEQRES   3 K  122  GLY SER GLY ARG LYS THR ALA ASN ILE GLY ASP VAL ILE          
SEQRES   4 K  122  VAL CYS THR VAL LYS GLN ALA THR PRO GLY GLY VAL VAL          
SEQRES   5 K  122  LYS LYS GLY GLU VAL VAL LYS ALA VAL ILE VAL ARG THR          
SEQRES   6 K  122  LYS SER GLY ALA ARG ARG SER ASP GLY SER TYR ILE SER          
SEQRES   7 K  122  PHE ASP GLU ASN ALA CYS VAL ILE ILE ARG ASP ASP LYS          
SEQRES   8 K  122  SER PRO ARG GLY THR ARG ILE PHE GLY PRO VAL ALA ARG          
SEQRES   9 K  122  GLU LEU ARG GLU ASN ASN PHE MET LYS ILE VAL SER LEU          
SEQRES  10 K  122  ALA PRO GLU VAL ILE                                          
SEQRES   1 L  146  MET LYS LEU HIS GLU LEU LYS PRO SER GLU GLY SER ARG          
SEQRES   2 L  146  LYS THR ARG ASN ARG VAL GLY ARG GLY ILE GLY SER GLY          
SEQRES   3 L  146  ASN GLY LYS THR ALA GLY LYS GLY HIS LYS GLY GLN ASN          
SEQRES   4 L  146  ALA ARG SER GLY GLY GLY VAL ARG PRO GLY PHE GLU GLY          
SEQRES   5 L  146  GLY GLN MET PRO LEU PHE GLN ARG LEU PRO LYS ARG GLY          
SEQRES   6 L  146  PHE THR ASN ILE ASN ARG LYS GLU TYR ALA VAL VAL ASN          
SEQRES   7 L  146  LEU ASP LYS LEU ASN GLY PHE ALA GLU GLY THR GLU VAL          
SEQRES   8 L  146  THR PRO GLU LEU LEU LEU GLU THR GLY VAL ILE SER LYS          
SEQRES   9 L  146  LEU ASN ALA GLY VAL LYS ILE LEU GLY ASN GLY LYS LEU          
SEQRES  10 L  146  GLU LYS LYS LEU THR VAL LYS ALA ASN LYS PHE SER ALA          
SEQRES  11 L  146  SER ALA LYS GLU ALA VAL GLU ALA ALA GLY GLY THR ALA          
SEQRES  12 L  146  GLU VAL ILE                                                  
SEQRES   1 N  120  MET SER TYR ARG LYS LEU GLY ARG THR SER ALA GLN ARG          
SEQRES   2 N  120  LYS ALA MET LEU ARG ASP LEU THR THR ASP LEU ILE ILE          
SEQRES   3 N  120  ASN GLU ARG ILE GLU THR THR GLU THR ARG ALA LYS GLU          
SEQRES   4 N  120  LEU ARG SER VAL VAL GLU LYS MET ILE THR LEU GLY LYS          
SEQRES   5 N  120  ARG GLY ASP LEU HIS ALA ARG ARG GLN ALA ALA ALA TYR          
SEQRES   6 N  120  ILE ARG ASN GLU VAL ALA ASN GLU GLU ASN ASN GLN ASP          
SEQRES   7 N  120  ALA LEU GLN LYS LEU PHE SER ASP ILE ALA THR ARG TYR          
SEQRES   8 N  120  GLU GLU ARG GLN GLY GLY TYR THR ARG ILE MET LYS LEU          
SEQRES   9 N  120  GLY PRO ARG ARG GLY ASP GLY ALA PRO MET ALA ILE ILE          
SEQRES  10 N  120  GLU LEU VAL                                                  
SEQRES   1 O  120  MET ILE THR LYS THR SER LYS ASN ALA ALA ARG LEU LYS          
SEQRES   2 O  120  ARG HIS ALA ARG VAL ARG ALA LYS LEU SER GLY THR ALA          
SEQRES   3 O  120  GLU ARG PRO ARG LEU ASN VAL PHE ARG SER ASN LYS HIS          
SEQRES   4 O  120  ILE TYR ALA GLN ILE ILE ASP ASP VAL ASN GLY VAL THR          
SEQRES   5 O  120  LEU ALA SER ALA SER THR LEU ASP LYS ASP LEU ASN VAL          
SEQRES   6 O  120  GLU SER THR GLY ASP THR SER ALA ALA THR LYS VAL GLY          
SEQRES   7 O  120  GLU LEU VAL ALA LYS ARG ALA ALA GLU LYS GLY ILE SER          
SEQRES   8 O  120  ASP VAL VAL PHE ASP ARG GLY GLY TYR LEU TYR HIS GLY          
SEQRES   9 O  120  ARG VAL LYS ALA LEU ALA ASP ALA ALA ARG GLU ALA GLY          
SEQRES  10 O  120  LEU LYS PHE                                                  
SEQRES   1 P  115  MET GLN LYS LEU ILE GLU ASP ILE THR LYS GLU GLN LEU          
SEQRES   2 P  115  ARG THR ASP LEU PRO ALA PHE ARG PRO GLY ASP THR LEU          
SEQRES   3 P  115  ARG VAL HIS VAL LYS VAL VAL GLU GLY ASN ARG GLU ARG          
SEQRES   4 P  115  ILE GLN ILE PHE GLU GLY VAL VAL ILE LYS ARG ARG GLY          
SEQRES   5 P  115  GLY GLY ILE SER GLU THR PHE THR VAL ARG LYS ILE SER          
SEQRES   6 P  115  TYR GLY VAL GLY VAL GLU ARG THR PHE PRO VAL HIS THR          
SEQRES   7 P  115  PRO LYS ILE ALA LYS ILE GLU VAL VAL ARG TYR GLY LYS          
SEQRES   8 P  115  VAL ARG ARG ALA LYS LEU TYR TYR LEU ARG GLU LEU ARG          
SEQRES   9 P  115  GLY LYS ALA ALA ARG ILE LYS GLU ILE ARG ARG                  
SEQRES   1 Q  118  PRO ARG VAL LYS GLY GLY THR VAL THR ARG LYS ARG ARG          
SEQRES   2 Q  118  LYS LYS VAL LEU LYS LEU ALA LYS GLY TYR PHE GLY SER          
SEQRES   3 Q  118  LYS HIS THR LEU TYR LYS VAL ALA ASN GLN GLN VAL MET          
SEQRES   4 Q  118  LYS SER GLY ASN TYR ALA PHE ARG ASP ARG ARG GLN LYS          
SEQRES   5 Q  118  LYS ARG ASP PHE ARG LYS LEU TRP ILE THR ARG ILE ASN          
SEQRES   6 Q  118  ALA ALA ALA ARG MET ASN GLY LEU SER TYR SER ARG LEU          
SEQRES   7 Q  118  MET HIS GLY LEU LYS LEU SER GLY ILE GLU VAL ASN ARG          
SEQRES   8 Q  118  LYS MET LEU ALA ASP LEU ALA VAL ASN ASP LEU THR ALA          
SEQRES   9 Q  118  PHE ASN GLN LEU ALA ASP ALA ALA LYS ALA GLN LEU ASN          
SEQRES  10 Q  118  LYS                                                          
SEQRES   1 R  102  MET TYR ALA ILE ILE LYS THR GLY GLY LYS GLN ILE LYS          
SEQRES   2 R  102  VAL GLU GLU GLY GLN THR VAL TYR ILE GLU LYS LEU ALA          
SEQRES   3 R  102  ALA GLU ALA GLY GLU THR VAL THR PHE GLU ASP VAL LEU          
SEQRES   4 R  102  PHE VAL GLY GLY ASP ASN VAL LYS VAL GLY ASN PRO THR          
SEQRES   5 R  102  VAL GLU GLY ALA THR VAL THR ALA LYS VAL GLU LYS GLN          
SEQRES   6 R  102  GLY ARG ALA LYS LYS ILE THR VAL PHE ARG TYR LYS PRO          
SEQRES   7 R  102  LYS LYS ASN VAL HIS LYS LYS GLN GLY HIS ARG GLN PRO          
SEQRES   8 R  102  TYR THR LYS VAL THR ILE GLU LYS ILE ASN ALA                  
SEQRES   1 S  113  MET GLN ALA LYS ALA VAL ALA ARG THR VAL ARG ILE ALA          
SEQRES   2 S  113  PRO ARG LYS ALA ARG LEU VAL MET ASP LEU ILE ARG GLY          
SEQRES   3 S  113  LYS GLN VAL GLY GLU ALA VAL SER ILE LEU ASN LEU THR          
SEQRES   4 S  113  PRO ARG ALA ALA SER PRO ILE ILE GLU LYS VAL LEU LYS          
SEQRES   5 S  113  SER ALA ILE ALA ASN ALA GLU HIS ASN TYR GLU MET ASP          
SEQRES   6 S  113  ALA ASN ASN LEU VAL ILE SER GLN ALA PHE VAL ASP GLU          
SEQRES   7 S  113  GLY PRO THR LEU LYS ARG PHE ARG PRO ARG ALA MET GLY          
SEQRES   8 S  113  ARG ALA SER GLN ILE ASN LYS ARG THR SER HIS ILE THR          
SEQRES   9 S  113  ILE VAL VAL SER GLU LYS LYS GLU GLY                          
SEQRES   1 T   95  MET LYS ASP PRO ARG ASP VAL LEU LYS ARG PRO VAL ILE          
SEQRES   2 T   95  THR GLU ARG SER ALA ASP LEU MET THR GLU LYS LYS TYR          
SEQRES   3 T   95  THR PHE GLU VAL ASP VAL ARG ALA ASN LYS THR GLU VAL          
SEQRES   4 T   95  LYS ASP ALA VAL GLU SER ILE PHE GLY VAL LYS VAL ASP          
SEQRES   5 T   95  LYS VAL ASN ILE MET ASN TYR LYS GLY LYS SER LYS ARG          
SEQRES   6 T   95  VAL GLY ARG TYR THR GLY MET THR SER ARG ARG ARG LYS          
SEQRES   7 T   95  ALA ILE VAL LYS LEU THR ALA ASP SER LYS GLU ILE GLU          
SEQRES   8 T   95  ILE PHE GLU ALA                                              
SEQRES   1 U  103  MET HIS VAL LYS LYS GLY ASP LYS VAL MET VAL ILE SER          
SEQRES   2 U  103  GLY LYS ASP LYS GLY LYS GLN GLY THR ILE LEU ALA ALA          
SEQRES   3 U  103  PHE PRO LYS LYS ASP ARG VAL LEU VAL GLU GLY VAL ASN          
SEQRES   4 U  103  MET VAL LYS LYS HIS SER LYS PRO THR GLN ALA ASN PRO          
SEQRES   5 U  103  GLN GLY GLY ILE SER ASN GLN GLU ALA PRO ILE HIS VAL          
SEQRES   6 U  103  SER ASN VAL MET PRO LEU ASP PRO LYS THR GLY GLU VAL          
SEQRES   7 U  103  THR ARG VAL GLY TYR LYS VAL GLU ASP GLY LYS LYS VAL          
SEQRES   8 U  103  ARG VAL ALA LYS LYS SER GLY GLN VAL LEU ASP LYS              
SEQRES   1 V   94  MET LEU ARG LEU ASP LEU GLN PHE PHE ALA SER LYS LYS          
SEQRES   2 V   94  GLY VAL GLY SER THR LYS ASN GLY ARG ASP SER GLU ALA          
SEQRES   3 V   94  LYS ARG LEU GLY ALA LYS ARG ALA ASP GLY GLN PHE VAL          
SEQRES   4 V   94  THR GLY GLY SER ILE LEU TYR ARG GLN ARG GLY THR LYS          
SEQRES   5 V   94  ILE TYR PRO GLY GLU ASN VAL GLY ARG GLY GLY ASP ASP          
SEQRES   6 V   94  THR LEU PHE ALA LYS ILE ASP GLY THR VAL LYS PHE GLU          
SEQRES   7 V   94  ARG PHE GLY ARG ASP ARG LYS LYS VAL SER VAL TYR PRO          
SEQRES   8 V   94  VAL ALA GLN                                                  
SEQRES   1 Z   59  MET ALA LYS LEU GLU ILE THR LEU LYS ARG SER VAL ILE          
SEQRES   2 Z   59  GLY ARG PRO GLU ASP GLN ARG VAL THR VAL ARG THR LEU          
SEQRES   3 Z   59  GLY LEU LYS LYS THR ASN GLN THR VAL VAL HIS GLU ASP          
SEQRES   4 Z   59  ASN ALA ALA ILE ARG GLY MET ILE ASN LYS VAL SER HIS          
SEQRES   5 Z   59  LEU VAL SER VAL LYS GLU GLN                                  
SEQRES   1 b   59  MET ALA VAL PRO PHE ARG ARG THR SER LYS MET LYS LYS          
SEQRES   2 b   59  ARG LEU ARG ARG THR HIS PHE LYS LEU ASN VAL PRO GLY          
SEQRES   3 b   59  MET THR GLU CYS PRO SER CYS GLY GLU MET LYS LEU SER          
SEQRES   4 b   59  HIS ARG VAL CYS LYS ALA CYS GLY SER TYR ASN GLY LYS          
SEQRES   5 b   59  ASP ILE ASN VAL LYS SER ASN                                  
SEQRES   1 Y   66  MET LYS ALA ASN GLU ILE ARG ASP LEU THR THR ALA GLU          
SEQRES   2 Y   66  ILE GLU GLN LYS VAL LYS SER LEU LYS GLU GLU LEU PHE          
SEQRES   3 Y   66  ASN LEU ARG PHE GLN LEU ALA THR GLY GLN LEU GLU ASN          
SEQRES   4 Y   66  THR ALA ARG ILE ARG GLU VAL ARG LYS ALA ILE ALA ARG          
SEQRES   5 Y   66  MET LYS THR VAL ILE ARG GLU ARG GLU ILE ALA ALA ASN          
SEQRES   6 Y   66  LYS                                                          
SEQRES   1 d   44  MET LYS ARG THR PHE GLN PRO ASN ASN ARG LYS ARG SER          
SEQRES   2 d   44  LYS VAL HIS GLY PHE ARG SER ARG MET SER SER LYS ASN          
SEQRES   3 d   44  GLY ARG LEU VAL LEU ALA ARG ARG ARG ARG LYS GLY ARG          
SEQRES   4 d   44  LYS VAL LEU SER ALA                                          
SEQRES   1 W  282  MET THR ILE GLN TRP PHE PRO GLY HIS MET ALA LYS ALA          
SEQRES   2 W  282  ARG ARG GLU VAL THR GLU LYS LEU LYS LEU ILE ASP ILE          
SEQRES   3 W  282  VAL TYR GLU LEU VAL ASP ALA ARG ILE PRO MET SER SER          
SEQRES   4 W  282  ARG ASN PRO MET ILE GLU ASP ILE LEU LYS ASN LYS PRO          
SEQRES   5 W  282  ARG ILE MET LEU LEU ASN LYS ALA ASP LYS ALA ASP ALA          
SEQRES   6 W  282  ALA VAL THR GLN GLN TRP LYS GLU HIS PHE GLU ASN GLN          
SEQRES   7 W  282  GLY ILE ARG SER LEU SER ILE ASN SER VAL ASN GLY GLN          
SEQRES   8 W  282  GLY LEU ASN GLN ILE VAL PRO ALA SER LYS GLU ILE LEU          
SEQRES   9 W  282  GLN GLU LYS PHE ASP ARG MET ARG ALA LYS GLY VAL LYS          
SEQRES  10 W  282  PRO ARG ALA ILE ARG ALA LEU ILE ILE GLY ILE PRO ASN          
SEQRES  11 W  282  VAL GLY LYS SER THR LEU ILE ASN ARG LEU ALA LYS LYS          
SEQRES  12 W  282  ASN ILE ALA LYS THR GLY ASP ARG PRO GLY ILE THR THR          
SEQRES  13 W  282  SER GLN GLN TRP VAL LYS VAL GLY LYS GLU LEU GLU LEU          
SEQRES  14 W  282  LEU ASP THR PRO GLY ILE LEU TRP PRO LYS PHE GLU ASP          
SEQRES  15 W  282  GLU LEU VAL GLY LEU ARG LEU ALA VAL THR GLY ALA ILE          
SEQRES  16 W  282  LYS ASP SER ILE ILE ASN LEU GLN ASP VAL ALA VAL PHE          
SEQRES  17 W  282  GLY LEU ARG PHE LEU GLU GLU HIS TYR PRO GLU ARG LEU          
SEQRES  18 W  282  LYS GLU ARG TYR GLY LEU ASP GLU ILE PRO GLU ASP ILE          
SEQRES  19 W  282  ALA GLU LEU PHE ASP ALA ILE GLY GLU LYS ARG GLY CYS          
SEQRES  20 W  282  LEU MET SER GLY GLY LEU ILE ASN TYR ASP LYS THR THR          
SEQRES  21 W  282  GLU VAL ILE ILE ARG ASP ILE ARG THR GLU LYS PHE GLY          
SEQRES  22 W  282  ARG LEU SER PHE GLU GLN PRO THR MET                          
HET    GNP  W 301      32                                                       
HETNAM     GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER                      
FORMUL  25  GNP    C10 H17 N6 O13 P3                                            
HELIX    1 AA1 GLU C   30  SER C   32  5                                   3    
HELIX    2 AA2 ILE C  133  ILE C  135  5                                   3    
HELIX    3 AA3 ASN C  197  ILE C  203  5                                   7    
HELIX    4 AA4 LYS C  207  GLY C  215  1                                   9    
HELIX    5 AA5 ARG C  221  MET C  225  5                                   5    
HELIX    6 AA6 ASN C  264  LYS C  268  5                                   5    
HELIX    7 AA7 THR D   40  GLY D   45  1                                   6    
HELIX    8 AA8 ASN D   62  HIS D   68  1                                   7    
HELIX    9 AA9 GLY D  121  GLY D  127  1                                   7    
HELIX   10 AB1 ASN E   29  ARG E   41  1                                  13    
HELIX   11 AB2 PRO E  102  ASN E  121  1                                  20    
HELIX   12 AB3 THR E  136  LEU E  146  1                                  11    
HELIX   13 AB4 ASN E  160  LEU E  165  1                                   6    
HELIX   14 AB5 ASN E  179  ILE E  181  5                                   3    
HELIX   15 AB6 ASN E  182  GLU E  190  1                                   9    
HELIX   16 AB7 THR E  195  LEU E  206  1                                  12    
HELIX   17 AB8 GLU F   11  LEU F   16  1                                   6    
HELIX   18 AB9 GLU F   94  SER F  107  1                                  14    
HELIX   19 AC1 THR F  162  GLN F  172  1                                  11    
HELIX   20 AC2 GLU G   61  LYS G   82  1                                  22    
HELIX   21 AC3 ASP G  138  ALA G  151  1                                  14    
HELIX   22 AC4 THR J   25  ARG J   38  1                                  14    
HELIX   23 AC5 THR J   89  TYR J   97  1                                   9    
HELIX   24 AC6 TYR J   97  LEU J  110  1                                  14    
HELIX   25 AC7 SER J  114  LYS J  121  1                                   8    
HELIX   26 AC8 HIS J  133  LYS J  137  5                                   5    
HELIX   27 AC9 THR L   92  THR L   99  1                                   8    
HELIX   28 AD1 SER L  129  GLU L  137  1                                   9    
HELIX   29 AD2 THR N    9  GLU N   28  1                                  20    
HELIX   30 AD3 GLU N   34  LYS N   52  1                                  19    
HELIX   31 AD4 ASP N   55  ALA N   64  1                                  10    
HELIX   32 AD5 ALA N   79  TYR N   91  1                                  13    
HELIX   33 AD6 ASN O    8  LYS O   21  1                                  14    
HELIX   34 AD7 ALA O   73  VAL O   77  5                                   5    
HELIX   35 AD8 GLU O   79  ARG O   84  1                                   6    
HELIX   36 AD9 ALA O   85  LYS O   88  5                                   4    
HELIX   37 AE1 GLY O  104  ALA O  116  1                                  13    
HELIX   38 AE2 LYS P    6  LEU P   16  1                                  11    
HELIX   39 AE3 GLY P   56  GLU P   60  5                                   5    
HELIX   40 AE4 LEU P  100  GLU P  105  5                                   6    
HELIX   41 AE5 ARG P  112  GLU P  115  5                                   4    
HELIX   42 AE6 THR Q    8  LEU Q   20  1                                  13    
HELIX   43 AE7 PHE Q   25  THR Q   30  5                                   6    
HELIX   44 AE8 LEU Q   31  ASN Q   36  1                                   6    
HELIX   45 AE9 GLN Q   38  GLY Q   73  1                                  36    
HELIX   46 AF1 SER Q   75  SER Q   86  1                                  12    
HELIX   47 AF2 ARG Q   92  ASP Q   97  1                                   6    
HELIX   48 AF3 PHE Q  106  ALA Q  115  1                                  10    
HELIX   49 AF4 ALA S   17  ASP S   22  1                                   6    
HELIX   50 AF5 GLN S   28  LEU S   36  1                                   9    
HELIX   51 AF6 ALA S   43  GLU S   63  1                                  21    
HELIX   52 AF7 ASP S   65  ASN S   67  5                                   3    
HELIX   53 AF8 ARG S   88  ARG S   92  5                                   5    
HELIX   54 AF9 THR T   14  LEU T   20  1                                   7    
HELIX   55 AG1 ASN T   35  PHE T   47  1                                  13    
HELIX   56 AG2 SER U   13  LYS U   17  5                                   5    
HELIX   57 AG3 SER U   66  VAL U   68  5                                   3    
HELIX   58 AG4 PRO Z   16  GLY Z   27  1                                  12    
HELIX   59 AG5 ASN Z   40  VAL Z   50  1                                  11    
HELIX   60 AG6 ARG b   16  LYS b   21  5                                   6    
HELIX   61 AG7 THR Y   10  GLY Y   35  1                                  26    
HELIX   62 AG8 ASN Y   39  ASN Y   65  1                                  27    
HELIX   63 AG9 ASN d    8  HIS d   16  1                                   9    
HELIX   64 AH1 SER d   24  GLY d   38  1                                  15    
HELIX   65 AH2 MET W   10  THR W   18  1                                   9    
HELIX   66 AH3 GLU W   19  LEU W   21  5                                   3    
HELIX   67 AH4 PRO W   36  ARG W   40  5                                   5    
HELIX   68 AH5 MET W   43  LEU W   48  1                                   6    
HELIX   69 AH6 ALA W   66  ASN W   77  1                                  12    
HELIX   70 AH7 PRO W   98  ILE W  103  1                                   6    
HELIX   71 AH8 LEU W  104  PHE W  108  5                                   5    
HELIX   72 AH9 LEU W  189  GLY W  193  5                                   5    
HELIX   73 AI1 LEU W  202  HIS W  216  1                                  15    
HELIX   74 AI2 TYR W  217  GLU W  219  5                                   3    
HELIX   75 AI3 ARG W  220  TYR W  225  1                                   6    
HELIX   76 AI4 ALA W  235  GLY W  246  1                                  12    
HELIX   77 AI5 ASN W  255  ARG W  268  1                                  14    
SHEET    1 AA1 2 LYS C   4  LYS C   5  0                                        
SHEET    2 AA1 2 THR C  17  THR C  18 -1  O  THR C  18   N  LYS C   4           
SHEET    1 AA2 2 LEU C  34  PRO C  36  0                                        
SHEET    2 AA2 2 GLN C  61  ARG C  63 -1  O  TYR C  62   N  ALA C  35           
SHEET    1 AA3 4 LYS C 101  ALA C 106  0                                        
SHEET    2 AA3 4 ASN C  90  TYR C  96 -1  N  ALA C  92   O  ILE C 104           
SHEET    3 AA3 4 PRO C  75  GLU C  82 -1  N  ARG C  77   O  ASN C  95           
SHEET    4 AA3 4 GLU C 115  MET C 117 -1  O  ILE C 116   N  GLY C  76           
SHEET    1 AA4 3 ALA C 129  PRO C 131  0                                        
SHEET    2 AA4 3 ARG C 189  ILE C 192 -1  O  ALA C 190   N  LEU C 130           
SHEET    3 AA4 3 VAL C 141  HIS C 142 -1  N  HIS C 142   O  SER C 191           
SHEET    1 AA5 4 GLN C 163  LYS C 167  0                                        
SHEET    2 AA5 4 VAL C 172  ARG C 175 -1  O  ARG C 175   N  GLN C 163           
SHEET    3 AA5 4 VAL C 181  ILE C 184 -1  O  ILE C 184   N  VAL C 172           
SHEET    4 AA5 4 ILE C 270  ARG C 272 -1  O  VAL C 271   N  VAL C 181           
SHEET    1 AA6 7 GLN D 168  LEU D 174  0                                        
SHEET    2 AA6 7 VAL D 108  VAL D 113 -1  N  VAL D 108   O  LEU D 174           
SHEET    3 AA6 7 LEU D 199  SER D 204 -1  O  LYS D 203   N  ASP D 109           
SHEET    4 AA6 7 GLY D   4  VAL D  15 -1  N  ILE D   5   O  VAL D 202           
SHEET    5 AA6 7 ILE D  23  GLU D  29 -1  O  VAL D  25   N  THR D  13           
SHEET    6 AA6 7 LEU D 185  ILE D 188 -1  O  LEU D 186   N  ILE D  28           
SHEET    7 AA6 7 ILE D 176  ASP D 180 -1  N  ASP D 180   O  LEU D 185           
SHEET    1 AA7 2 ASN D  33  VAL D  34  0                                        
SHEET    2 AA7 2 GLU D  96  VAL D  97 -1  O  VAL D  97   N  ASN D  33           
SHEET    1 AA8 2 LYS D  38  LYS D  39  0                                        
SHEET    2 AA8 2 ALA D  48  ILE D  49 -1  O  ALA D  48   N  LYS D  39           
SHEET    1 AA9 2 LEU D  51  PHE D  53  0                                        
SHEET    2 AA9 2 ARG D  78  LYS D  81 -1  O  LYS D  81   N  LEU D  51           
SHEET    1 AB1 5 LEU E   6  TYR E   7  0                                        
SHEET    2 AB1 5 ILE E 123  LEU E 126  1  O  VAL E 125   N  TYR E   7           
SHEET    3 AB1 5 LEU E 192  ILE E 194  1  O  LEU E 192   N  ILE E 124           
SHEET    4 AB1 5 ALA E 152  THR E 156  1  N  VAL E 155   O  LEU E 193           
SHEET    5 AB1 5 VAL E 173  GLU E 177  1  O  THR E 174   N  ILE E 154           
SHEET    1 AB2 5 VAL F  66  VAL F  67  0                                        
SHEET    2 AB2 5 ALA F  87  LEU F  91 -1  O  LYS F  88   N  VAL F  66           
SHEET    3 AB2 5 ILE F  34  ASN F  37 -1  N  ILE F  36   O  VAL F  89           
SHEET    4 AB2 5 MET F 152  ILE F 156 -1  O  VAL F 155   N  VAL F  35           
SHEET    5 AB2 5 TYR F 128  ILE F 132 -1  N  TYR F 128   O  ILE F 156           
SHEET    1 AB3 4 ILE G 122  GLU G 125  0                                        
SHEET    2 AB3 4 LYS G 131  GLY G 136 -1  O  LYS G 135   N  GLU G 123           
SHEET    3 AB3 4 PHE G  84  LEU G  90 -1  N  LEU G  88   O  VAL G 132           
SHEET    4 AB3 4 ILE G 163  TYR G 165 -1  O  ARG G 164   N  GLU G  89           
SHEET    1 AB4 2 LEU G 104  VAL G 105  0                                        
SHEET    2 AB4 2 GLU G 115  ILE G 116 -1  O  ILE G 116   N  LEU G 104           
SHEET    1 AB5 4 LEU J 123  VAL J 125  0                                        
SHEET    2 AB5 4 VAL J  55  ILE J  58  1  N  ILE J  57   O  ASN J 124           
SHEET    3 AB5 4 LEU J  17  ASP J  20  1  N  VAL J  19   O  ILE J  58           
SHEET    4 AB5 4 GLU J 139  VAL J 140  1  O  GLU J 139   N  VAL J  18           
SHEET    1 AB6 2 TYR J  75  TYR J  76  0                                        
SHEET    2 AB6 2 SER J  87  ARG J  88 -1  O  ARG J  88   N  TYR J  75           
SHEET    1 AB7 6 ARG K   7  VAL K  10  0                                        
SHEET    2 AB7 6 ALA K  16  VAL K  24 -1  O  VAL K  19   N  LEU K   8           
SHEET    3 AB7 6 VAL K  38  ALA K  46 -1  O  GLN K  45   N  ARG K  17           
SHEET    4 AB7 6 VAL K  57  ILE K  62 -1  O  VAL K  58   N  CYS K  41           
SHEET    5 AB7 6 ALA K  83  VAL K  85 -1  O  VAL K  85   N  VAL K  61           
SHEET    6 AB7 6 ARG K   7  VAL K  10  1  N  LYS K   9   O  CYS K  84           
SHEET    1 AB8 7 ALA K  69  ARG K  70  0                                        
SHEET    2 AB8 7 TYR K  76  PHE K  79 -1  O  ILE K  77   N  ALA K  69           
SHEET    3 AB8 7 VAL P  71  ARG P  75 -1  O  GLU P  74   N  SER K  78           
SHEET    4 AB8 7 VAL P  64  SER P  68 -1  N  VAL P  64   O  ARG P  75           
SHEET    5 AB8 7 GLN P  44  VAL P  50 -1  N  VAL P  49   O  ARG P  65           
SHEET    6 AB8 7 THR P  28  VAL P  33 -1  N  VAL P  31   O  PHE P  46           
SHEET    7 AB8 7 ILE P  84  ARG P  91 -1  O  GLU P  88   N  ARG P  30           
SHEET    1 AB9 2 ALA L  75  VAL L  77  0                                        
SHEET    2 AB9 2 VAL L 109  ILE L 111  1  O  LYS L 110   N  VAL L  77           
SHEET    1 AC1 2 LYS L 124  ALA L 125  0                                        
SHEET    2 AC1 2 GLU L 144  VAL L 145  1  O  GLU L 144   N  ALA L 125           
SHEET    1 AC2 3 ARG N  29  THR N  33  0                                        
SHEET    2 AC2 3 PRO N 113  LEU N 119 -1  O  ILE N 117   N  ILE N  30           
SHEET    3 AC2 3 THR N  99  PRO N 106 -1  N  LEU N 104   O  MET N 114           
SHEET    1 AC3 2 VAL N  70  ASN N  72  0                                        
SHEET    2 AC3 2 GLN N  77  ASP N  78 -1  O  GLN N  77   N  ASN N  72           
SHEET    1 AC4 2 ARG O  30  LEU O  31  0                                        
SHEET    2 AC4 2 ILE O  44  ILE O  45 -1  O  ILE O  45   N  ARG O  30           
SHEET    1 AC5 2 PHE O  34  ARG O  35  0                                        
SHEET    2 AC5 2 ILE O  40  TYR O  41 -1  O  TYR O  41   N  PHE O  34           
SHEET    1 AC6 2 GLY P  93  LYS P  94  0                                        
SHEET    2 AC6 2 ILE P 116  ARG P 117 -1  O  ILE P 116   N  LYS P  94           
SHEET    1 AC7 2 ALA R   3  ILE R   5  0                                        
SHEET    2 AC7 2 ILE R  12  VAL R  14 -1  O  VAL R  14   N  ALA R   3           
SHEET    1 AC8 3 THR R  19  ILE R  22  0                                        
SHEET    2 AC8 3 PRO R  91  ILE R 100 -1  O  VAL R  95   N  VAL R  20           
SHEET    3 AC8 3 VAL R  58  ARG R  67 -1  N  LYS R  64   O  LYS R  94           
SHEET    1 AC9 2 ILE R  71  TYR R  76  0                                        
SHEET    2 AC9 2 HIS R  83  HIS R  88 -1  O  GLN R  86   N  VAL R  73           
SHEET    1 AD1 3 ALA S   3  VAL S   6  0                                        
SHEET    2 AD1 3 HIS S 102  GLU S 109 -1  O  VAL S 107   N  ALA S   3           
SHEET    3 AD1 3 LEU S  69  GLN S  73 -1  N  VAL S  70   O  SER S 108           
SHEET    1 AD2 3 ALA S   3  VAL S   6  0                                        
SHEET    2 AD2 3 HIS S 102  GLU S 109 -1  O  VAL S 107   N  ALA S   3           
SHEET    3 AD2 3 VAL S  76  ASP S  77 -1  N  ASP S  77   O  HIS S 102           
SHEET    1 AD3 2 ARG S  84  ARG S  86  0                                        
SHEET    2 AD3 2 SER S  94  ILE S  96 -1  O  ILE S  96   N  ARG S  84           
SHEET    1 AD4 3 LYS T  25  GLU T  29  0                                        
SHEET    2 AD4 3 LYS T  78  LEU T  83 -1  O  VAL T  81   N  TYR T  26           
SHEET    3 AD4 3 VAL T  51  ILE T  56 -1  N  LYS T  53   O  LYS T  82           
SHEET    1 AD5 2 VAL U   9  MET U  10  0                                        
SHEET    2 AD5 2 MET U  69  PRO U  70 -1  O  MET U  69   N  MET U  10           
SHEET    1 AD6 3 ILE U  23  PHE U  27  0                                        
SHEET    2 AD6 3 ARG U  32  VAL U  35 -1  O  ARG U  32   N  PHE U  27           
SHEET    3 AD6 3 ILE U  63  HIS U  64 -1  O  ILE U  63   N  VAL U  33           
SHEET    1 AD7 2 MET U  40  VAL U  41  0                                        
SHEET    2 AD7 2 GLN U  59  GLU U  60 -1  O  GLN U  59   N  VAL U  41           
SHEET    1 AD8 3 GLY V  30  ALA V  31  0                                        
SHEET    2 AD8 3 ILE V  44  ARG V  47 -1  O  ARG V  47   N  GLY V  30           
SHEET    3 AD8 3 LEU V  67  PHE V  68 -1  O  LEU V  67   N  LEU V  45           
SHEET    1 AD9 3 TYR V  54  PRO V  55  0                                        
SHEET    2 AD9 3 ARG V  84  TYR V  90  1  O  VAL V  87   N  TYR V  54           
SHEET    3 AD9 3 THR V  74  PHE V  80 -1  N  PHE V  80   O  ARG V  84           
SHEET    1 AE1 3 VAL Z  35  GLU Z  38  0                                        
SHEET    2 AE1 3 LYS Z   3  LEU Z   8 -1  N  LEU Z   4   O  HIS Z  37           
SHEET    3 AE1 3 VAL Z  54  GLU Z  58 -1  O  LYS Z  57   N  GLU Z   5           
SHEET    1 AE2 2 MET b  27  THR b  28  0                                        
SHEET    2 AE2 2 LYS b  37  LEU b  38 -1  O  LYS b  37   N  THR b  28           
SHEET    1 AE3 4 ARG W  81  SER W  82  0                                        
SHEET    2 AE3 4 ARG W  53  ASN W  58  1  N  MET W  55   O  ARG W  81           
SHEET    3 AE3 4 ILE W  26  ASP W  32  1  N  VAL W  31   O  LEU W  56           
SHEET    4 AE3 4 ALA W 123  ILE W 125  1  O  LEU W 124   N  TYR W  28           
SHEET    1 AE4 2 LEU W 248  SER W 250  0                                        
SHEET    2 AE4 2 LEU W 253  ILE W 254 -1  O  LEU W 253   N  MET W 249           
SITE     1 AC1 16 ASN W  58  LYS W  59  SER W  87  PRO W 129                    
SITE     2 AC1 16 ASN W 130  GLY W 132  LYS W 133  SER W 134                    
SITE     3 AC1 16 THR W 135  THR W 148  PRO W 152  GLY W 153                    
SITE     4 AC1 16 ILE W 154  THR W 172  PRO W 173  GLY W 174                    
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1           1          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      1.000000  0.000000  0.000000        0.00000                         
SCALE2      0.000000  1.000000  0.000000        0.00000                         
SCALE3      0.000000  0.000000  1.000000        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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