GenomeNet

Database: PDB
Entry: 6Q2N
LinkDB: 6Q2N
Original site: 6Q2N 
HEADER    SIGNALING PROTEIN                       08-AUG-19   6Q2N              
TITLE     CRYO-EM STRUCTURE OF RET/GFRA1/GDNF EXTRACELLULAR COMPLEX             
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR;               
COMPND   3 CHAIN: A, B;                                                         
COMPND   4 SYNONYM: HGDNF,ASTROCYTE-DERIVED TROPHIC FACTOR,ATF;                 
COMPND   5 ENGINEERED: YES;                                                     
COMPND   6 MOL_ID: 2;                                                           
COMPND   7 MOLECULE: GDNF FAMILY RECEPTOR ALPHA-1;                              
COMPND   8 CHAIN: C, D;                                                         
COMPND   9 SYNONYM: GFR-ALPHA-1,RET LIGAND 1,TGF-BETA-RELATED NEUROTROPHIC      
COMPND  10 FACTOR RECEPTOR 1;                                                   
COMPND  11 ENGINEERED: YES;                                                     
COMPND  12 MOL_ID: 3;                                                           
COMPND  13 MOLECULE: PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET;       
COMPND  14 CHAIN: E, F;                                                         
COMPND  15 SYNONYM: CADHERIN FAMILY MEMBER 12,PROTO-ONCOGENE C-RET;             
COMPND  16 EC: 2.7.10.1;                                                        
COMPND  17 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   3 ORGANISM_COMMON: HUMAN;                                              
SOURCE   4 ORGANISM_TAXID: 9606;                                                
SOURCE   5 GENE: GDNF;                                                          
SOURCE   6 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE   8 MOL_ID: 2;                                                           
SOURCE   9 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  10 ORGANISM_COMMON: HUMAN;                                              
SOURCE  11 ORGANISM_TAXID: 9606;                                                
SOURCE  12 GENE: GFRA1, GDNFRA, RETL1, TRNR1;                                   
SOURCE  13 EXPRESSION_SYSTEM: HOMO SAPIENS;                                     
SOURCE  14 EXPRESSION_SYSTEM_COMMON: HUMAN;                                     
SOURCE  15 EXPRESSION_SYSTEM_TAXID: 9606;                                       
SOURCE  16 MOL_ID: 3;                                                           
SOURCE  17 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  18 ORGANISM_COMMON: HUMAN;                                              
SOURCE  19 ORGANISM_TAXID: 9606;                                                
SOURCE  20 GENE: RET, CDHF12, CDHR16, PTC, RET51;                               
SOURCE  21 EXPRESSION_SYSTEM: HOMO SAPIENS;                                     
SOURCE  22 EXPRESSION_SYSTEM_COMMON: HUMAN;                                     
SOURCE  23 EXPRESSION_SYSTEM_TAXID: 9606                                        
KEYWDS    RET, RECEPTOR TYROSINE KINASE, CRYO-EM, SIGNALING PROTEIN             
EXPDTA    ELECTRON MICROSCOPY                                                   
AUTHOR    J.LI,G.J.SHANG,Y.J.CHEN,C.A.BRAUTIGAM,J.LIOU,X.W.ZHANG,X.C.BAI        
REVDAT   1   02-OCT-19 6Q2N    0                                                
JRNL        AUTH   J.LI,G.SHANG,Y.J.CHEN,C.A.BRAUTIGAM,J.LIOU,X.ZHANG,X.C.BAI   
JRNL        TITL   CRYO-EM ANALYSES REVEAL THE COMMON MECHANISM AND             
JRNL        TITL 2 DIVERSIFICATION IN THE ACTIVATION OF RET BY DIFFERENT        
JRNL        TITL 3 LIGANDS.                                                     
JRNL        REF    ELIFE                         V.   8       2019              
JRNL        REFN                   ESSN 2050-084X                               
JRNL        PMID   31535977                                                     
JRNL        DOI    10.7554/ELIFE.47650                                          
REMARK   2                                                                      
REMARK   2 RESOLUTION.    4.40 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   SOFTWARE PACKAGES      : RELION, EPU, RELION, COOT, PHENIX,        
REMARK   3                            RELION, RELION, RELION, RELION            
REMARK   3   RECONSTRUCTION SCHEMA  : NULL                                      
REMARK   3                                                                      
REMARK   3 EM MAP-MODEL FITTING AND REFINEMENT                                  
REMARK   3   PDB ENTRY                    : NULL                                
REMARK   3   REFINEMENT SPACE             : REAL                                
REMARK   3   REFINEMENT PROTOCOL          : FLEXIBLE FIT                        
REMARK   3   REFINEMENT TARGET            : NULL                                
REMARK   3   OVERALL ANISOTROPIC B VALUE  : 190.000                             
REMARK   3                                                                      
REMARK   3 FITTING PROCEDURE : NULL                                             
REMARK   3                                                                      
REMARK   3 EM IMAGE RECONSTRUCTION STATISTICS                                   
REMARK   3   NOMINAL PIXEL SIZE (ANGSTROMS)    : NULL                           
REMARK   3   ACTUAL PIXEL SIZE  (ANGSTROMS)    : NULL                           
REMARK   3   EFFECTIVE RESOLUTION (ANGSTROMS)  : 4.400                          
REMARK   3   NUMBER OF PARTICLES               : 37098                          
REMARK   3   CTF CORRECTION METHOD             : PHASE FLIPPING AND AMPLITUDE   
REMARK   3                                       CORRECTION                     
REMARK   3                                                                      
REMARK   3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL                    
REMARK   3                                                                      
REMARK   3 OTHER DETAILS: NULL                                                  
REMARK   4                                                                      
REMARK   4 6Q2N COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 09-AUG-19.                  
REMARK 100 THE DEPOSITION ID IS D_1000243536.                                   
REMARK 245                                                                      
REMARK 245 EXPERIMENTAL DETAILS                                                 
REMARK 245   RECONSTRUCTION METHOD          : SINGLE PARTICLE                   
REMARK 245   SPECIMEN TYPE                  : NULL                              
REMARK 245                                                                      
REMARK 245 ELECTRON MICROSCOPE SAMPLE                                           
REMARK 245   SAMPLE TYPE                    : PARTICLE                          
REMARK 245   PARTICLE TYPE                  : POINT                             
REMARK 245   NAME OF SAMPLE                 : RET, GFRAL AND GDF15              
REMARK 245                                    EXTRACELLULAR COMPLEX             
REMARK 245   SAMPLE CONCENTRATION (MG ML-1) : 1.00                              
REMARK 245   SAMPLE SUPPORT DETAILS         : NULL                              
REMARK 245   SAMPLE VITRIFICATION DETAILS   : NULL                              
REMARK 245   SAMPLE BUFFER                  : NULL                              
REMARK 245   PH                             : 7.40                              
REMARK 245   SAMPLE DETAILS                 : NULL                              
REMARK 245                                                                      
REMARK 245 DATA ACQUISITION                                                     
REMARK 245   DATE OF EXPERIMENT                : NULL                           
REMARK 245   NUMBER OF MICROGRAPHS-IMAGES      : NULL                           
REMARK 245   TEMPERATURE (KELVIN)              : NULL                           
REMARK 245   MICROSCOPE MODEL                  : FEI TITAN KRIOS                
REMARK 245   DETECTOR TYPE                     : GATAN K2 QUANTUM (4K X 4K)     
REMARK 245   MINIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MAXIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MINIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   MAXIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   NOMINAL CS                        : 2.70                           
REMARK 245   IMAGING MODE                      : BRIGHT FIELD                   
REMARK 245   ELECTRON DOSE (ELECTRONS NM**-2)  : 50.00                          
REMARK 245   ILLUMINATION MODE                 : FLOOD BEAM                     
REMARK 245   NOMINAL MAGNIFICATION             : NULL                           
REMARK 245   CALIBRATED MAGNIFICATION          : 46729                          
REMARK 245   SOURCE                            : FIELD EMISSION GUN             
REMARK 245   ACCELERATION VOLTAGE (KV)         : 300                            
REMARK 245   IMAGING DETAILS                   : NULL                           
REMARK 247                                                                      
REMARK 247 ELECTRON MICROSCOPY                                                  
REMARK 247  THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON          
REMARK 247  MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE              
REMARK 247  THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES           
REMARK 247  ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION         
REMARK 247  OF THE STRUCTURE FACTORS.                                           
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: HEXAMERIC                         
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, C, E, B, D, F                      
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     SER A    78                                                      
REMARK 465     PRO A    79                                                      
REMARK 465     ASP A    80                                                      
REMARK 465     LYS A    81                                                      
REMARK 465     GLN A    82                                                      
REMARK 465     MET A    83                                                      
REMARK 465     ALA A    84                                                      
REMARK 465     VAL A    85                                                      
REMARK 465     LEU A    86                                                      
REMARK 465     PRO A    87                                                      
REMARK 465     ARG A    88                                                      
REMARK 465     ARG A    89                                                      
REMARK 465     GLU A    90                                                      
REMARK 465     ARG A    91                                                      
REMARK 465     ASN A    92                                                      
REMARK 465     ARG A    93                                                      
REMARK 465     GLN A    94                                                      
REMARK 465     ALA A    95                                                      
REMARK 465     ALA A    96                                                      
REMARK 465     ALA A    97                                                      
REMARK 465     ALA A    98                                                      
REMARK 465     ASN A    99                                                      
REMARK 465     PRO A   100                                                      
REMARK 465     GLU A   101                                                      
REMARK 465     ASN A   102                                                      
REMARK 465     SER A   103                                                      
REMARK 465     ARG A   104                                                      
REMARK 465     GLY A   105                                                      
REMARK 465     LYS A   106                                                      
REMARK 465     GLY A   107                                                      
REMARK 465     ARG A   108                                                      
REMARK 465     ARG A   109                                                      
REMARK 465     GLY A   110                                                      
REMARK 465     GLN A   111                                                      
REMARK 465     ARG A   112                                                      
REMARK 465     GLY A   113                                                      
REMARK 465     LYS A   114                                                      
REMARK 465     ASN A   115                                                      
REMARK 465     ARG A   116                                                      
REMARK 465     ARG A   165                                                      
REMARK 465     ASN A   166                                                      
REMARK 465     ARG A   167                                                      
REMARK 465     ARG A   168                                                      
REMARK 465     LEU A   169                                                      
REMARK 465     VAL A   170                                                      
REMARK 465     SER A   171                                                      
REMARK 465     ASP A   172                                                      
REMARK 465     ILE A   211                                                      
REMARK 465     ASP C    25                                                      
REMARK 465     ARG C    26                                                      
REMARK 465     LEU C    27                                                      
REMARK 465     ASP C    28                                                      
REMARK 465     CYS C    29                                                      
REMARK 465     VAL C    30                                                      
REMARK 465     LYS C    31                                                      
REMARK 465     ALA C    32                                                      
REMARK 465     SER C    33                                                      
REMARK 465     ASP C    34                                                      
REMARK 465     GLN C    35                                                      
REMARK 465     CYS C    36                                                      
REMARK 465     LEU C    37                                                      
REMARK 465     LYS C    38                                                      
REMARK 465     GLU C    39                                                      
REMARK 465     GLN C    40                                                      
REMARK 465     SER C    41                                                      
REMARK 465     CYS C    42                                                      
REMARK 465     SER C    43                                                      
REMARK 465     THR C    44                                                      
REMARK 465     LYS C    45                                                      
REMARK 465     TYR C    46                                                      
REMARK 465     ARG C    47                                                      
REMARK 465     THR C    48                                                      
REMARK 465     LEU C    49                                                      
REMARK 465     ARG C    50                                                      
REMARK 465     GLN C    51                                                      
REMARK 465     CYS C    52                                                      
REMARK 465     VAL C    53                                                      
REMARK 465     ALA C    54                                                      
REMARK 465     GLY C    55                                                      
REMARK 465     LYS C    56                                                      
REMARK 465     GLU C    57                                                      
REMARK 465     THR C    58                                                      
REMARK 465     ASN C    59                                                      
REMARK 465     PHE C    60                                                      
REMARK 465     SER C    61                                                      
REMARK 465     LEU C    62                                                      
REMARK 465     ALA C    63                                                      
REMARK 465     SER C    64                                                      
REMARK 465     GLY C    65                                                      
REMARK 465     LEU C    66                                                      
REMARK 465     GLU C    67                                                      
REMARK 465     ALA C    68                                                      
REMARK 465     LYS C    69                                                      
REMARK 465     ASP C    70                                                      
REMARK 465     GLU C    71                                                      
REMARK 465     CYS C    72                                                      
REMARK 465     ARG C    73                                                      
REMARK 465     SER C    74                                                      
REMARK 465     ALA C    75                                                      
REMARK 465     MET C    76                                                      
REMARK 465     GLU C    77                                                      
REMARK 465     ALA C    78                                                      
REMARK 465     LEU C    79                                                      
REMARK 465     LYS C    80                                                      
REMARK 465     GLN C    81                                                      
REMARK 465     LYS C    82                                                      
REMARK 465     SER C    83                                                      
REMARK 465     LEU C    84                                                      
REMARK 465     TYR C    85                                                      
REMARK 465     ASN C    86                                                      
REMARK 465     CYS C    87                                                      
REMARK 465     ARG C    88                                                      
REMARK 465     CYS C    89                                                      
REMARK 465     LYS C    90                                                      
REMARK 465     ARG C    91                                                      
REMARK 465     GLY C    92                                                      
REMARK 465     MET C    93                                                      
REMARK 465     LYS C    94                                                      
REMARK 465     LYS C    95                                                      
REMARK 465     GLU C    96                                                      
REMARK 465     LYS C    97                                                      
REMARK 465     ASN C    98                                                      
REMARK 465     CYS C    99                                                      
REMARK 465     LEU C   100                                                      
REMARK 465     ARG C   101                                                      
REMARK 465     ILE C   102                                                      
REMARK 465     TYR C   103                                                      
REMARK 465     TRP C   104                                                      
REMARK 465     SER C   105                                                      
REMARK 465     MET C   106                                                      
REMARK 465     TYR C   107                                                      
REMARK 465     GLN C   108                                                      
REMARK 465     SER C   109                                                      
REMARK 465     LEU C   110                                                      
REMARK 465     GLN C   111                                                      
REMARK 465     GLY C   112                                                      
REMARK 465     ASN C   113                                                      
REMARK 465     ASP C   114                                                      
REMARK 465     LEU C   115                                                      
REMARK 465     LEU C   116                                                      
REMARK 465     GLU C   117                                                      
REMARK 465     ASP C   118                                                      
REMARK 465     SER C   119                                                      
REMARK 465     PRO C   120                                                      
REMARK 465     TYR C   121                                                      
REMARK 465     GLU C   122                                                      
REMARK 465     PRO C   123                                                      
REMARK 465     VAL C   124                                                      
REMARK 465     ASN C   125                                                      
REMARK 465     SER C   126                                                      
REMARK 465     ARG C   127                                                      
REMARK 465     LEU C   128                                                      
REMARK 465     SER C   129                                                      
REMARK 465     ASP C   130                                                      
REMARK 465     ILE C   131                                                      
REMARK 465     PHE C   132                                                      
REMARK 465     ARG C   133                                                      
REMARK 465     VAL C   134                                                      
REMARK 465     VAL C   135                                                      
REMARK 465     PRO C   136                                                      
REMARK 465     PHE C   137                                                      
REMARK 465     ILE C   138                                                      
REMARK 465     SER C   139                                                      
REMARK 465     ASP C   140                                                      
REMARK 465     VAL C   141                                                      
REMARK 465     PHE C   142                                                      
REMARK 465     GLN C   143                                                      
REMARK 465     GLN C   144                                                      
REMARK 465     VAL C   145                                                      
REMARK 465     GLU C   146                                                      
REMARK 465     HIS C   147                                                      
REMARK 465     ILE C   148                                                      
REMARK 465     PRO C   149                                                      
REMARK 465     ASP C   350                                                      
REMARK 465     VAL C   351                                                      
REMARK 465     THR C   352                                                      
REMARK 465     VAL C   353                                                      
REMARK 465     TRP C   354                                                      
REMARK 465     GLN C   355                                                      
REMARK 465     PRO C   356                                                      
REMARK 465     ALA C   357                                                      
REMARK 465     PHE C   358                                                      
REMARK 465     PRO C   359                                                      
REMARK 465     VAL C   360                                                      
REMARK 465     GLN C   361                                                      
REMARK 465     THR C   362                                                      
REMARK 465     THR C   363                                                      
REMARK 465     THR C   364                                                      
REMARK 465     ALA C   365                                                      
REMARK 465     THR C   366                                                      
REMARK 465     THR C   367                                                      
REMARK 465     THR C   368                                                      
REMARK 465     THR C   369                                                      
REMARK 465     ALA C   370                                                      
REMARK 465     LEU C   371                                                      
REMARK 465     ARG C   372                                                      
REMARK 465     VAL C   373                                                      
REMARK 465     LYS C   374                                                      
REMARK 465     ASN C   375                                                      
REMARK 465     LYS C   376                                                      
REMARK 465     PRO C   377                                                      
REMARK 465     LEU C   378                                                      
REMARK 465     GLY C   379                                                      
REMARK 465     PRO C   380                                                      
REMARK 465     ALA C   381                                                      
REMARK 465     GLY C   382                                                      
REMARK 465     SER C   383                                                      
REMARK 465     GLU C   384                                                      
REMARK 465     ASN C   385                                                      
REMARK 465     GLU C   386                                                      
REMARK 465     ILE C   387                                                      
REMARK 465     PRO C   388                                                      
REMARK 465     THR C   389                                                      
REMARK 465     HIS C   390                                                      
REMARK 465     VAL C   391                                                      
REMARK 465     LEU C   392                                                      
REMARK 465     PRO C   393                                                      
REMARK 465     PRO C   394                                                      
REMARK 465     CYS C   395                                                      
REMARK 465     ALA C   396                                                      
REMARK 465     ASN C   397                                                      
REMARK 465     LEU C   398                                                      
REMARK 465     GLN C   399                                                      
REMARK 465     ALA C   400                                                      
REMARK 465     GLN C   401                                                      
REMARK 465     LYS C   402                                                      
REMARK 465     LEU C   403                                                      
REMARK 465     LYS C   404                                                      
REMARK 465     SER C   405                                                      
REMARK 465     ASN C   406                                                      
REMARK 465     VAL C   407                                                      
REMARK 465     SER C   408                                                      
REMARK 465     GLY C   409                                                      
REMARK 465     ASN C   410                                                      
REMARK 465     THR C   411                                                      
REMARK 465     HIS C   412                                                      
REMARK 465     LEU C   413                                                      
REMARK 465     CYS C   414                                                      
REMARK 465     ILE C   415                                                      
REMARK 465     SER C   416                                                      
REMARK 465     ASN C   417                                                      
REMARK 465     GLY C   418                                                      
REMARK 465     ASN C   419                                                      
REMARK 465     TYR C   420                                                      
REMARK 465     GLU C   421                                                      
REMARK 465     LYS C   422                                                      
REMARK 465     GLU C   423                                                      
REMARK 465     GLY C   424                                                      
REMARK 465     LEU C   425                                                      
REMARK 465     GLY C   426                                                      
REMARK 465     GLY C   427                                                      
REMARK 465     THR C   428                                                      
REMARK 465     HIS C   429                                                      
REMARK 465     HIS C   430                                                      
REMARK 465     HIS C   431                                                      
REMARK 465     HIS C   432                                                      
REMARK 465     HIS C   433                                                      
REMARK 465     HIS C   434                                                      
REMARK 465     HIS C   435                                                      
REMARK 465     HIS C   436                                                      
REMARK 465     PRO E   129                                                      
REMARK 465     THR E   130                                                      
REMARK 465     SER E   131                                                      
REMARK 465     LEU E   132                                                      
REMARK 465     ARG E   133                                                      
REMARK 465     GLU E   134                                                      
REMARK 465     GLU E   208                                                      
REMARK 465     GLY E   209                                                      
REMARK 465     GLU E   210                                                      
REMARK 465     ALA E   247                                                      
REMARK 465     GLY E   248                                                      
REMARK 465     ALA E   249                                                      
REMARK 465     ARG E   250                                                      
REMARK 465     ASP E   380                                                      
REMARK 465     PHE E   381                                                      
REMARK 465     GLN E   382                                                      
REMARK 465     GLY E   383                                                      
REMARK 465     PRO E   384                                                      
REMARK 465     GLY E   385                                                      
REMARK 465     ALA E   386                                                      
REMARK 465     GLY E   387                                                      
REMARK 465     GLY E   446                                                      
REMARK 465     ALA E   447                                                      
REMARK 465     ASN E   448                                                      
REMARK 465     ASP E   469                                                      
REMARK 465     THR E   470                                                      
REMARK 465     LYS E   471                                                      
REMARK 465     ALA E   472                                                      
REMARK 465     LEU E   473                                                      
REMARK 465     ARG E   474                                                      
REMARK 465     ARG E   475                                                      
REMARK 465     SER E   507                                                      
REMARK 465     TYR E   508                                                      
REMARK 465     VAL E   509                                                      
REMARK 465     ALA E   510                                                      
REMARK 465     GLU E   511                                                      
REMARK 465     GLU E   512                                                      
REMARK 465     ALA E   513                                                      
REMARK 465     GLY E   514                                                      
REMARK 465     ASP E   547                                                      
REMARK 465     GLY E   548                                                      
REMARK 465     GLU E   623                                                      
REMARK 465     ASP E   624                                                      
REMARK 465     ILE E   625                                                      
REMARK 465     GLN E   626                                                      
REMARK 465     ASP E   627                                                      
REMARK 465     PRO E   628                                                      
REMARK 465     LEU E   629                                                      
REMARK 465     CYS E   630                                                      
REMARK 465     ASP E   631                                                      
REMARK 465     GLU E   632                                                      
REMARK 465     LEU E   633                                                      
REMARK 465     CYS E   634                                                      
REMARK 465     ARG E   635                                                      
REMARK 465     GLY E   636                                                      
REMARK 465     THR E   637                                                      
REMARK 465     HIS E   638                                                      
REMARK 465     HIS E   639                                                      
REMARK 465     HIS E   640                                                      
REMARK 465     HIS E   641                                                      
REMARK 465     HIS E   642                                                      
REMARK 465     HIS E   643                                                      
REMARK 465     HIS E   644                                                      
REMARK 465     HIS E   645                                                      
REMARK 465     SER B    78                                                      
REMARK 465     PRO B    79                                                      
REMARK 465     ASP B    80                                                      
REMARK 465     LYS B    81                                                      
REMARK 465     GLN B    82                                                      
REMARK 465     MET B    83                                                      
REMARK 465     ALA B    84                                                      
REMARK 465     VAL B    85                                                      
REMARK 465     LEU B    86                                                      
REMARK 465     PRO B    87                                                      
REMARK 465     ARG B    88                                                      
REMARK 465     ARG B    89                                                      
REMARK 465     GLU B    90                                                      
REMARK 465     ARG B    91                                                      
REMARK 465     ASN B    92                                                      
REMARK 465     ARG B    93                                                      
REMARK 465     GLN B    94                                                      
REMARK 465     ALA B    95                                                      
REMARK 465     ALA B    96                                                      
REMARK 465     ALA B    97                                                      
REMARK 465     ALA B    98                                                      
REMARK 465     ASN B    99                                                      
REMARK 465     PRO B   100                                                      
REMARK 465     GLU B   101                                                      
REMARK 465     ASN B   102                                                      
REMARK 465     SER B   103                                                      
REMARK 465     ARG B   104                                                      
REMARK 465     GLY B   105                                                      
REMARK 465     LYS B   106                                                      
REMARK 465     GLY B   107                                                      
REMARK 465     ARG B   108                                                      
REMARK 465     ARG B   109                                                      
REMARK 465     GLY B   110                                                      
REMARK 465     GLN B   111                                                      
REMARK 465     ARG B   112                                                      
REMARK 465     GLY B   113                                                      
REMARK 465     LYS B   114                                                      
REMARK 465     ASN B   115                                                      
REMARK 465     ARG B   116                                                      
REMARK 465     ARG B   165                                                      
REMARK 465     ASN B   166                                                      
REMARK 465     ARG B   167                                                      
REMARK 465     ARG B   168                                                      
REMARK 465     LEU B   169                                                      
REMARK 465     VAL B   170                                                      
REMARK 465     SER B   171                                                      
REMARK 465     ASP B   172                                                      
REMARK 465     ILE B   211                                                      
REMARK 465     ASP D    25                                                      
REMARK 465     ARG D    26                                                      
REMARK 465     LEU D    27                                                      
REMARK 465     ASP D    28                                                      
REMARK 465     CYS D    29                                                      
REMARK 465     VAL D    30                                                      
REMARK 465     LYS D    31                                                      
REMARK 465     ALA D    32                                                      
REMARK 465     SER D    33                                                      
REMARK 465     ASP D    34                                                      
REMARK 465     GLN D    35                                                      
REMARK 465     CYS D    36                                                      
REMARK 465     LEU D    37                                                      
REMARK 465     LYS D    38                                                      
REMARK 465     GLU D    39                                                      
REMARK 465     GLN D    40                                                      
REMARK 465     SER D    41                                                      
REMARK 465     CYS D    42                                                      
REMARK 465     SER D    43                                                      
REMARK 465     THR D    44                                                      
REMARK 465     LYS D    45                                                      
REMARK 465     TYR D    46                                                      
REMARK 465     ARG D    47                                                      
REMARK 465     THR D    48                                                      
REMARK 465     LEU D    49                                                      
REMARK 465     ARG D    50                                                      
REMARK 465     GLN D    51                                                      
REMARK 465     CYS D    52                                                      
REMARK 465     VAL D    53                                                      
REMARK 465     ALA D    54                                                      
REMARK 465     GLY D    55                                                      
REMARK 465     LYS D    56                                                      
REMARK 465     GLU D    57                                                      
REMARK 465     THR D    58                                                      
REMARK 465     ASN D    59                                                      
REMARK 465     PHE D    60                                                      
REMARK 465     SER D    61                                                      
REMARK 465     LEU D    62                                                      
REMARK 465     ALA D    63                                                      
REMARK 465     SER D    64                                                      
REMARK 465     GLY D    65                                                      
REMARK 465     LEU D    66                                                      
REMARK 465     GLU D    67                                                      
REMARK 465     ALA D    68                                                      
REMARK 465     LYS D    69                                                      
REMARK 465     ASP D    70                                                      
REMARK 465     GLU D    71                                                      
REMARK 465     CYS D    72                                                      
REMARK 465     ARG D    73                                                      
REMARK 465     SER D    74                                                      
REMARK 465     ALA D    75                                                      
REMARK 465     MET D    76                                                      
REMARK 465     GLU D    77                                                      
REMARK 465     ALA D    78                                                      
REMARK 465     LEU D    79                                                      
REMARK 465     LYS D    80                                                      
REMARK 465     GLN D    81                                                      
REMARK 465     LYS D    82                                                      
REMARK 465     SER D    83                                                      
REMARK 465     LEU D    84                                                      
REMARK 465     TYR D    85                                                      
REMARK 465     ASN D    86                                                      
REMARK 465     CYS D    87                                                      
REMARK 465     ARG D    88                                                      
REMARK 465     CYS D    89                                                      
REMARK 465     LYS D    90                                                      
REMARK 465     ARG D    91                                                      
REMARK 465     GLY D    92                                                      
REMARK 465     MET D    93                                                      
REMARK 465     LYS D    94                                                      
REMARK 465     LYS D    95                                                      
REMARK 465     GLU D    96                                                      
REMARK 465     LYS D    97                                                      
REMARK 465     ASN D    98                                                      
REMARK 465     CYS D    99                                                      
REMARK 465     LEU D   100                                                      
REMARK 465     ARG D   101                                                      
REMARK 465     ILE D   102                                                      
REMARK 465     TYR D   103                                                      
REMARK 465     TRP D   104                                                      
REMARK 465     SER D   105                                                      
REMARK 465     MET D   106                                                      
REMARK 465     TYR D   107                                                      
REMARK 465     GLN D   108                                                      
REMARK 465     SER D   109                                                      
REMARK 465     LEU D   110                                                      
REMARK 465     GLN D   111                                                      
REMARK 465     GLY D   112                                                      
REMARK 465     ASN D   113                                                      
REMARK 465     ASP D   114                                                      
REMARK 465     LEU D   115                                                      
REMARK 465     LEU D   116                                                      
REMARK 465     GLU D   117                                                      
REMARK 465     ASP D   118                                                      
REMARK 465     SER D   119                                                      
REMARK 465     PRO D   120                                                      
REMARK 465     TYR D   121                                                      
REMARK 465     GLU D   122                                                      
REMARK 465     PRO D   123                                                      
REMARK 465     VAL D   124                                                      
REMARK 465     ASN D   125                                                      
REMARK 465     SER D   126                                                      
REMARK 465     ARG D   127                                                      
REMARK 465     LEU D   128                                                      
REMARK 465     SER D   129                                                      
REMARK 465     ASP D   130                                                      
REMARK 465     ILE D   131                                                      
REMARK 465     PHE D   132                                                      
REMARK 465     ARG D   133                                                      
REMARK 465     VAL D   134                                                      
REMARK 465     VAL D   135                                                      
REMARK 465     PRO D   136                                                      
REMARK 465     PHE D   137                                                      
REMARK 465     ILE D   138                                                      
REMARK 465     SER D   139                                                      
REMARK 465     ASP D   140                                                      
REMARK 465     VAL D   141                                                      
REMARK 465     PHE D   142                                                      
REMARK 465     GLN D   143                                                      
REMARK 465     GLN D   144                                                      
REMARK 465     VAL D   145                                                      
REMARK 465     GLU D   146                                                      
REMARK 465     HIS D   147                                                      
REMARK 465     ILE D   148                                                      
REMARK 465     PRO D   149                                                      
REMARK 465     ASP D   350                                                      
REMARK 465     VAL D   351                                                      
REMARK 465     THR D   352                                                      
REMARK 465     VAL D   353                                                      
REMARK 465     TRP D   354                                                      
REMARK 465     GLN D   355                                                      
REMARK 465     PRO D   356                                                      
REMARK 465     ALA D   357                                                      
REMARK 465     PHE D   358                                                      
REMARK 465     PRO D   359                                                      
REMARK 465     VAL D   360                                                      
REMARK 465     GLN D   361                                                      
REMARK 465     THR D   362                                                      
REMARK 465     THR D   363                                                      
REMARK 465     THR D   364                                                      
REMARK 465     ALA D   365                                                      
REMARK 465     THR D   366                                                      
REMARK 465     THR D   367                                                      
REMARK 465     THR D   368                                                      
REMARK 465     THR D   369                                                      
REMARK 465     ALA D   370                                                      
REMARK 465     LEU D   371                                                      
REMARK 465     ARG D   372                                                      
REMARK 465     VAL D   373                                                      
REMARK 465     LYS D   374                                                      
REMARK 465     ASN D   375                                                      
REMARK 465     LYS D   376                                                      
REMARK 465     PRO D   377                                                      
REMARK 465     LEU D   378                                                      
REMARK 465     GLY D   379                                                      
REMARK 465     PRO D   380                                                      
REMARK 465     ALA D   381                                                      
REMARK 465     GLY D   382                                                      
REMARK 465     SER D   383                                                      
REMARK 465     GLU D   384                                                      
REMARK 465     ASN D   385                                                      
REMARK 465     GLU D   386                                                      
REMARK 465     ILE D   387                                                      
REMARK 465     PRO D   388                                                      
REMARK 465     THR D   389                                                      
REMARK 465     HIS D   390                                                      
REMARK 465     VAL D   391                                                      
REMARK 465     LEU D   392                                                      
REMARK 465     PRO D   393                                                      
REMARK 465     PRO D   394                                                      
REMARK 465     CYS D   395                                                      
REMARK 465     ALA D   396                                                      
REMARK 465     ASN D   397                                                      
REMARK 465     LEU D   398                                                      
REMARK 465     GLN D   399                                                      
REMARK 465     ALA D   400                                                      
REMARK 465     GLN D   401                                                      
REMARK 465     LYS D   402                                                      
REMARK 465     LEU D   403                                                      
REMARK 465     LYS D   404                                                      
REMARK 465     SER D   405                                                      
REMARK 465     ASN D   406                                                      
REMARK 465     VAL D   407                                                      
REMARK 465     SER D   408                                                      
REMARK 465     GLY D   409                                                      
REMARK 465     ASN D   410                                                      
REMARK 465     THR D   411                                                      
REMARK 465     HIS D   412                                                      
REMARK 465     LEU D   413                                                      
REMARK 465     CYS D   414                                                      
REMARK 465     ILE D   415                                                      
REMARK 465     SER D   416                                                      
REMARK 465     ASN D   417                                                      
REMARK 465     GLY D   418                                                      
REMARK 465     ASN D   419                                                      
REMARK 465     TYR D   420                                                      
REMARK 465     GLU D   421                                                      
REMARK 465     LYS D   422                                                      
REMARK 465     GLU D   423                                                      
REMARK 465     GLY D   424                                                      
REMARK 465     LEU D   425                                                      
REMARK 465     GLY D   426                                                      
REMARK 465     GLY D   427                                                      
REMARK 465     THR D   428                                                      
REMARK 465     HIS D   429                                                      
REMARK 465     HIS D   430                                                      
REMARK 465     HIS D   431                                                      
REMARK 465     HIS D   432                                                      
REMARK 465     HIS D   433                                                      
REMARK 465     HIS D   434                                                      
REMARK 465     HIS D   435                                                      
REMARK 465     HIS D   436                                                      
REMARK 465     PRO F   129                                                      
REMARK 465     THR F   130                                                      
REMARK 465     SER F   131                                                      
REMARK 465     LEU F   132                                                      
REMARK 465     ARG F   133                                                      
REMARK 465     GLU F   134                                                      
REMARK 465     GLU F   208                                                      
REMARK 465     GLY F   209                                                      
REMARK 465     GLU F   210                                                      
REMARK 465     ALA F   247                                                      
REMARK 465     GLY F   248                                                      
REMARK 465     ALA F   249                                                      
REMARK 465     ARG F   250                                                      
REMARK 465     ASP F   380                                                      
REMARK 465     PHE F   381                                                      
REMARK 465     GLN F   382                                                      
REMARK 465     GLY F   383                                                      
REMARK 465     PRO F   384                                                      
REMARK 465     GLY F   385                                                      
REMARK 465     ALA F   386                                                      
REMARK 465     GLY F   387                                                      
REMARK 465     GLY F   446                                                      
REMARK 465     ALA F   447                                                      
REMARK 465     ASN F   448                                                      
REMARK 465     ASP F   469                                                      
REMARK 465     THR F   470                                                      
REMARK 465     LYS F   471                                                      
REMARK 465     ALA F   472                                                      
REMARK 465     LEU F   473                                                      
REMARK 465     ARG F   474                                                      
REMARK 465     ARG F   475                                                      
REMARK 465     SER F   507                                                      
REMARK 465     TYR F   508                                                      
REMARK 465     VAL F   509                                                      
REMARK 465     ALA F   510                                                      
REMARK 465     GLU F   511                                                      
REMARK 465     GLU F   512                                                      
REMARK 465     ALA F   513                                                      
REMARK 465     GLY F   514                                                      
REMARK 465     ASP F   547                                                      
REMARK 465     GLY F   548                                                      
REMARK 465     GLU F   623                                                      
REMARK 465     ASP F   624                                                      
REMARK 465     ILE F   625                                                      
REMARK 465     GLN F   626                                                      
REMARK 465     ASP F   627                                                      
REMARK 465     PRO F   628                                                      
REMARK 465     LEU F   629                                                      
REMARK 465     CYS F   630                                                      
REMARK 465     ASP F   631                                                      
REMARK 465     GLU F   632                                                      
REMARK 465     LEU F   633                                                      
REMARK 465     CYS F   634                                                      
REMARK 465     ARG F   635                                                      
REMARK 465     GLY F   636                                                      
REMARK 465     THR F   637                                                      
REMARK 465     HIS F   638                                                      
REMARK 465     HIS F   639                                                      
REMARK 465     HIS F   640                                                      
REMARK 465     HIS F   641                                                      
REMARK 465     HIS F   642                                                      
REMARK 465     HIS F   643                                                      
REMARK 465     HIS F   644                                                      
REMARK 465     HIS F   645                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     ASP A 150    CG   OD1  OD2                                       
REMARK 470     LYS A 173    CG   CD   CE   NZ                                   
REMARK 470     ARG C 238    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG E 414    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS E 549    CG   CD   CE   NZ                                   
REMARK 470     ASP B 150    CG   OD1  OD2                                       
REMARK 470     LYS B 173    CG   CD   CE   NZ                                   
REMARK 470     ARG D 238    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG F 414    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS F 549    CG   CD   CE   NZ                                   
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   OD1  ASP E   567     OD2  ASP E   584              1.45            
REMARK 500   OD1  ASP F   567     OD2  ASP F   584              1.45            
REMARK 500   OD2  ASP E   300     OD2  ASP E   378              1.49            
REMARK 500   OD2  ASP F   300     OD2  ASP F   378              1.49            
REMARK 500   OD1  ASP F   266     OD2  ASP F   302              1.60            
REMARK 500   OD1  ASP E   266     OD2  ASP E   302              1.61            
REMARK 500   OD1  ASP E   230     OE1  GLU E   232              1.63            
REMARK 500   OD1  ASP F   230     OE1  GLU F   232              1.63            
REMARK 500   O    THR F   564     OD2  ASP F   567              1.98            
REMARK 500   O    THR E   564     OD2  ASP E   567              1.98            
REMARK 500   NH1  ARG F   180     OE2  GLU F   265              1.99            
REMARK 500   NH1  ARG E   180     OE2  GLU E   265              1.99            
REMARK 500   NH1  ARG F   330     O    LEU F   358              2.08            
REMARK 500   NH1  ARG E   330     O    LEU E   358              2.08            
REMARK 500   OE1  GLU F   178     OD1  ASP F   230              2.17            
REMARK 500   OE1  GLU E   178     OD1  ASP E   230              2.17            
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500    ALA E 269   C   -  N   -  CA  ANGL. DEV. =  19.8 DEGREES          
REMARK 500    ALA F 269   C   -  N   -  CA  ANGL. DEV. =  19.8 DEGREES          
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    CYS A 149     -166.44   -102.58                                   
REMARK 500    ALA A 151       -6.13     68.50                                   
REMARK 500    ALA A 152      -69.17   -125.60                                   
REMARK 500    GLU A 153       10.46     48.02                                   
REMARK 500    CYS C 187     -168.23   -162.98                                   
REMARK 500    ILE C 229       13.43   -141.25                                   
REMARK 500    VAL C 230       90.04     56.59                                   
REMARK 500    CYS C 267       39.96    -97.55                                   
REMARK 500    SER C 271     -176.60    -68.08                                   
REMARK 500    LYS C 279      -10.24     67.26                                   
REMARK 500    ILE C 302      -60.74   -123.83                                   
REMARK 500    LEU E  50      -61.77    -97.83                                   
REMARK 500    ARG E  77       43.99     39.69                                   
REMARK 500    ASN E 113        3.48    -63.93                                   
REMARK 500    SER E 220      113.78   -161.87                                   
REMARK 500    LEU E 221       33.81    -93.94                                   
REMARK 500    GLN E 233      -64.09    -91.35                                   
REMARK 500    GLU E 235      -13.74   -140.03                                   
REMARK 500    PHE E 258       84.65   -153.51                                   
REMARK 500    VAL E 293      -61.99   -105.08                                   
REMARK 500    ALA E 306     -177.87    -68.58                                   
REMARK 500    ILE E 422      -62.02   -121.91                                   
REMARK 500    GLN E 431       34.11    -93.10                                   
REMARK 500    SER E 434      -38.54   -130.01                                   
REMARK 500    CYS E 478       45.31   -141.43                                   
REMARK 500    ASN E 579       -8.91   -146.66                                   
REMARK 500    ARG E 600      175.05    179.23                                   
REMARK 500    CYS B 149     -166.50   -102.57                                   
REMARK 500    ALA B 151       -6.19     68.51                                   
REMARK 500    ALA B 152      -69.19   -125.54                                   
REMARK 500    GLU B 153       10.42     48.10                                   
REMARK 500    CYS D 187     -168.20   -162.99                                   
REMARK 500    ILE D 229       13.31   -141.24                                   
REMARK 500    VAL D 230       90.13     56.57                                   
REMARK 500    CYS D 267       39.95    -97.55                                   
REMARK 500    SER D 271     -176.62    -68.06                                   
REMARK 500    SER D 276       19.71     59.99                                   
REMARK 500    LYS D 279      -10.17     67.15                                   
REMARK 500    ILE D 302      -60.74   -123.86                                   
REMARK 500    LEU F  50      -61.68    -97.87                                   
REMARK 500    ARG F  77       44.06     39.73                                   
REMARK 500    ASN F 113        3.47    -63.88                                   
REMARK 500    SER F 220      113.77   -161.92                                   
REMARK 500    LEU F 221       33.73    -93.89                                   
REMARK 500    GLN F 233      -64.07    -91.34                                   
REMARK 500    GLU F 235      -13.66   -140.05                                   
REMARK 500    PHE F 258       84.66   -153.51                                   
REMARK 500    VAL F 293      -62.08   -105.05                                   
REMARK 500    ALA F 306     -177.92    -68.60                                   
REMARK 500    ILE F 422      -62.03   -121.96                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS      55 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS                                         
REMARK 500                                                                      
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH          
REMARK 500 CIS AND TRANS CONFORMATION.  CIS BONDS, IF ANY, ARE LISTED           
REMARK 500 ON CISPEP RECORDS.  TRANS IS DEFINED AS 180 +/- 30 AND               
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.                                  
REMARK 500                                 MODEL     OMEGA                      
REMARK 500 PRO E  566     ASP E  567                 -149.50                    
REMARK 500 PRO F  566     ASP F  567                 -149.45                    
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 620                                                                      
REMARK 620 METAL COORDINATION                                                   
REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE):                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              CA E2003  CA                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 GLU E 178   OE1                                                    
REMARK 620 2 GLU E 178   OE2  55.3                                              
REMARK 620 3 ASP E 230   OD1  53.9 108.3                                        
REMARK 620 4 GLU E 232   OE1  73.5 121.7  41.7                                  
REMARK 620 5 GLU E 232   OE2 102.2 106.7  97.3  56.0                            
REMARK 620 6 ASP E 267   OD2 158.8 110.3 132.6 125.8  96.9                      
REMARK 620 N                    1     2     3     4     5                       
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              CA E2002  CA                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 GLU E 178   OE2                                                    
REMARK 620 2 ASP E 264   OD1  76.6                                              
REMARK 620 3 GLU E 265   O   144.6  72.8                                        
REMARK 620 4 ASP E 267   OD1 131.4 106.3  75.0                                  
REMARK 620 5 ASP E 267   OD2  88.0 121.7 123.1  48.3                            
REMARK 620 N                    1     2     3     4                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              CA E2001  CA                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 ASP E 266   OD1                                                    
REMARK 620 2 SER E 268   O   105.0                                              
REMARK 620 3 ASP E 300   OD1 129.2  79.5                                        
REMARK 620 4 ASP E 300   OD2 131.6 120.9  53.9                                  
REMARK 620 5 ASP E 302   OD2  40.5  88.6  90.3 121.6                            
REMARK 620 6 ASP E 378   OD1  97.0 129.1 119.5  66.6 133.3                      
REMARK 620 7 ASP E 378   OD2 147.7 101.1  73.9  38.0 159.4  51.2                
REMARK 620 N                    1     2     3     4     5     6                 
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              CA E2004  CA                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 THR E 564   O                                                      
REMARK 620 2 CYS E 565   O    72.2                                              
REMARK 620 3 ASP E 567   OD1  81.0  58.6                                        
REMARK 620 4 ASP E 567   OD2  50.4  91.8  52.6                                  
REMARK 620 5 HIS E 569   O   111.4 137.3  79.5  66.0                            
REMARK 620 6 GLU E 574   OE1 115.4 134.2 160.6 129.1  84.5                      
REMARK 620 7 GLU E 574   OE2  66.1 104.1 146.7 105.0 116.5  51.7                
REMARK 620 8 ASP E 584   OD2 115.0  79.2  35.1  74.3  60.3 126.1 176.7          
REMARK 620 N                    1     2     3     4     5     6     7           
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              CA F2003  CA                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 GLU F 178   OE1                                                    
REMARK 620 2 GLU F 178   OE2  55.3                                              
REMARK 620 3 ASP F 230   OD1  53.9 108.3                                        
REMARK 620 4 GLU F 232   OE1  73.5 121.7  41.7                                  
REMARK 620 5 GLU F 232   OE2 102.3 106.8  97.4  56.0                            
REMARK 620 6 ASP F 267   OD2 158.7 110.3 132.6 125.8  96.9                      
REMARK 620 N                    1     2     3     4     5                       
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              CA F2002  CA                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 GLU F 178   OE2                                                    
REMARK 620 2 ASP F 264   OD1  76.6                                              
REMARK 620 3 GLU F 265   O   144.6  72.8                                        
REMARK 620 4 ASP F 267   OD1 131.5 106.3  75.0                                  
REMARK 620 5 ASP F 267   OD2  88.0 121.7 123.1  48.3                            
REMARK 620 N                    1     2     3     4                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              CA F2001  CA                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 ASP F 266   OD1                                                    
REMARK 620 2 SER F 268   O   105.0                                              
REMARK 620 3 ASP F 300   OD1 129.2  79.5                                        
REMARK 620 4 ASP F 300   OD2 131.6 120.8  53.9                                  
REMARK 620 5 ASP F 302   OD2  40.4  88.7  90.3 121.6                            
REMARK 620 6 ASP F 378   OD1  97.0 129.1 119.5  66.6 133.3                      
REMARK 620 7 ASP F 378   OD2 147.8 101.1  73.9  38.0 159.4  51.2                
REMARK 620 N                    1     2     3     4     5     6                 
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              CA F2004  CA                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 THR F 564   O                                                      
REMARK 620 2 CYS F 565   O    72.2                                              
REMARK 620 3 ASP F 567   OD1  81.0  58.5                                        
REMARK 620 4 ASP F 567   OD2  50.4  91.8  52.6                                  
REMARK 620 5 HIS F 569   O   111.4 137.3  79.5  66.0                            
REMARK 620 6 GLU F 574   OE1 115.3 134.2 160.7 129.1  84.6                      
REMARK 620 7 GLU F 574   OE2  66.1 104.0 146.7 105.0 116.5  51.7                
REMARK 620 8 ASP F 584   OD2 115.1  79.2  35.1  74.4  60.3 126.2 176.7          
REMARK 620 N                    1     2     3     4     5     6     7           
REMARK 800                                                                      
REMARK 800 SITE                                                                 
REMARK 800 SITE_IDENTIFIER: AC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue CA E 2001                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue CA E 2002                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue CA E 2003                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC4                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue CA E 2004                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC5                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue CA F 2001                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC6                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue CA F 2002                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC7                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue CA F 2003                 
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC8                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue CA F 2004                 
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: EMD-20575   RELATED DB: EMDB                             
REMARK 900 CRYO-EM STRUCTURE OF RET/GFRA1/GDNF EXTRACELLULAR COMPLEX.           
DBREF  6Q2N A   78   211  UNP    P39905   GDNF_HUMAN      78    211             
DBREF  6Q2N C   25   426  UNP    P56159   GFRA1_HUMAN     25    426             
DBREF  6Q2N E   29   635  UNP    P07949   RET_HUMAN       29    635             
DBREF  6Q2N B   78   211  UNP    P39905   GDNF_HUMAN      78    211             
DBREF  6Q2N D   25   426  UNP    P56159   GFRA1_HUMAN     25    426             
DBREF  6Q2N F   29   635  UNP    P07949   RET_HUMAN       29    635             
SEQADV 6Q2N GLY C  427  UNP  P56159              EXPRESSION TAG                 
SEQADV 6Q2N THR C  428  UNP  P56159              EXPRESSION TAG                 
SEQADV 6Q2N HIS C  429  UNP  P56159              EXPRESSION TAG                 
SEQADV 6Q2N HIS C  430  UNP  P56159              EXPRESSION TAG                 
SEQADV 6Q2N HIS C  431  UNP  P56159              EXPRESSION TAG                 
SEQADV 6Q2N HIS C  432  UNP  P56159              EXPRESSION TAG                 
SEQADV 6Q2N HIS C  433  UNP  P56159              EXPRESSION TAG                 
SEQADV 6Q2N HIS C  434  UNP  P56159              EXPRESSION TAG                 
SEQADV 6Q2N HIS C  435  UNP  P56159              EXPRESSION TAG                 
SEQADV 6Q2N HIS C  436  UNP  P56159              EXPRESSION TAG                 
SEQADV 6Q2N HIS E  114  UNP  P07949    ARG   114 CONFLICT                       
SEQADV 6Q2N GLY E  636  UNP  P07949              EXPRESSION TAG                 
SEQADV 6Q2N THR E  637  UNP  P07949              EXPRESSION TAG                 
SEQADV 6Q2N HIS E  638  UNP  P07949              EXPRESSION TAG                 
SEQADV 6Q2N HIS E  639  UNP  P07949              EXPRESSION TAG                 
SEQADV 6Q2N HIS E  640  UNP  P07949              EXPRESSION TAG                 
SEQADV 6Q2N HIS E  641  UNP  P07949              EXPRESSION TAG                 
SEQADV 6Q2N HIS E  642  UNP  P07949              EXPRESSION TAG                 
SEQADV 6Q2N HIS E  643  UNP  P07949              EXPRESSION TAG                 
SEQADV 6Q2N HIS E  644  UNP  P07949              EXPRESSION TAG                 
SEQADV 6Q2N HIS E  645  UNP  P07949              EXPRESSION TAG                 
SEQADV 6Q2N GLY D  427  UNP  P56159              EXPRESSION TAG                 
SEQADV 6Q2N THR D  428  UNP  P56159              EXPRESSION TAG                 
SEQADV 6Q2N HIS D  429  UNP  P56159              EXPRESSION TAG                 
SEQADV 6Q2N HIS D  430  UNP  P56159              EXPRESSION TAG                 
SEQADV 6Q2N HIS D  431  UNP  P56159              EXPRESSION TAG                 
SEQADV 6Q2N HIS D  432  UNP  P56159              EXPRESSION TAG                 
SEQADV 6Q2N HIS D  433  UNP  P56159              EXPRESSION TAG                 
SEQADV 6Q2N HIS D  434  UNP  P56159              EXPRESSION TAG                 
SEQADV 6Q2N HIS D  435  UNP  P56159              EXPRESSION TAG                 
SEQADV 6Q2N HIS D  436  UNP  P56159              EXPRESSION TAG                 
SEQADV 6Q2N HIS F  114  UNP  P07949    ARG   114 CONFLICT                       
SEQADV 6Q2N GLY F  636  UNP  P07949              EXPRESSION TAG                 
SEQADV 6Q2N THR F  637  UNP  P07949              EXPRESSION TAG                 
SEQADV 6Q2N HIS F  638  UNP  P07949              EXPRESSION TAG                 
SEQADV 6Q2N HIS F  639  UNP  P07949              EXPRESSION TAG                 
SEQADV 6Q2N HIS F  640  UNP  P07949              EXPRESSION TAG                 
SEQADV 6Q2N HIS F  641  UNP  P07949              EXPRESSION TAG                 
SEQADV 6Q2N HIS F  642  UNP  P07949              EXPRESSION TAG                 
SEQADV 6Q2N HIS F  643  UNP  P07949              EXPRESSION TAG                 
SEQADV 6Q2N HIS F  644  UNP  P07949              EXPRESSION TAG                 
SEQADV 6Q2N HIS F  645  UNP  P07949              EXPRESSION TAG                 
SEQRES   1 A  134  SER PRO ASP LYS GLN MET ALA VAL LEU PRO ARG ARG GLU          
SEQRES   2 A  134  ARG ASN ARG GLN ALA ALA ALA ALA ASN PRO GLU ASN SER          
SEQRES   3 A  134  ARG GLY LYS GLY ARG ARG GLY GLN ARG GLY LYS ASN ARG          
SEQRES   4 A  134  GLY CYS VAL LEU THR ALA ILE HIS LEU ASN VAL THR ASP          
SEQRES   5 A  134  LEU GLY LEU GLY TYR GLU THR LYS GLU GLU LEU ILE PHE          
SEQRES   6 A  134  ARG TYR CYS SER GLY SER CYS ASP ALA ALA GLU THR THR          
SEQRES   7 A  134  TYR ASP LYS ILE LEU LYS ASN LEU SER ARG ASN ARG ARG          
SEQRES   8 A  134  LEU VAL SER ASP LYS VAL GLY GLN ALA CYS CYS ARG PRO          
SEQRES   9 A  134  ILE ALA PHE ASP ASP ASP LEU SER PHE LEU ASP ASP ASN          
SEQRES  10 A  134  LEU VAL TYR HIS ILE LEU ARG LYS HIS SER ALA LYS ARG          
SEQRES  11 A  134  CYS GLY CYS ILE                                              
SEQRES   1 C  412  ASP ARG LEU ASP CYS VAL LYS ALA SER ASP GLN CYS LEU          
SEQRES   2 C  412  LYS GLU GLN SER CYS SER THR LYS TYR ARG THR LEU ARG          
SEQRES   3 C  412  GLN CYS VAL ALA GLY LYS GLU THR ASN PHE SER LEU ALA          
SEQRES   4 C  412  SER GLY LEU GLU ALA LYS ASP GLU CYS ARG SER ALA MET          
SEQRES   5 C  412  GLU ALA LEU LYS GLN LYS SER LEU TYR ASN CYS ARG CYS          
SEQRES   6 C  412  LYS ARG GLY MET LYS LYS GLU LYS ASN CYS LEU ARG ILE          
SEQRES   7 C  412  TYR TRP SER MET TYR GLN SER LEU GLN GLY ASN ASP LEU          
SEQRES   8 C  412  LEU GLU ASP SER PRO TYR GLU PRO VAL ASN SER ARG LEU          
SEQRES   9 C  412  SER ASP ILE PHE ARG VAL VAL PRO PHE ILE SER ASP VAL          
SEQRES  10 C  412  PHE GLN GLN VAL GLU HIS ILE PRO LYS GLY ASN ASN CYS          
SEQRES  11 C  412  LEU ASP ALA ALA LYS ALA CYS ASN LEU ASP ASP ILE CYS          
SEQRES  12 C  412  LYS LYS TYR ARG SER ALA TYR ILE THR PRO CYS THR THR          
SEQRES  13 C  412  SER VAL SER ASN ASP VAL CYS ASN ARG ARG LYS CYS HIS          
SEQRES  14 C  412  LYS ALA LEU ARG GLN PHE PHE ASP LYS VAL PRO ALA LYS          
SEQRES  15 C  412  HIS SER TYR GLY MET LEU PHE CYS SER CYS ARG ASP ILE          
SEQRES  16 C  412  ALA CYS THR GLU ARG ARG ARG GLN THR ILE VAL PRO VAL          
SEQRES  17 C  412  CYS SER TYR GLU GLU ARG GLU LYS PRO ASN CYS LEU ASN          
SEQRES  18 C  412  LEU GLN ASP SER CYS LYS THR ASN TYR ILE CYS ARG SER          
SEQRES  19 C  412  ARG LEU ALA ASP PHE PHE THR ASN CYS GLN PRO GLU SER          
SEQRES  20 C  412  ARG SER VAL SER SER CYS LEU LYS GLU ASN TYR ALA ASP          
SEQRES  21 C  412  CYS LEU LEU ALA TYR SER GLY LEU ILE GLY THR VAL MET          
SEQRES  22 C  412  THR PRO ASN TYR ILE ASP SER SER SER LEU SER VAL ALA          
SEQRES  23 C  412  PRO TRP CYS ASP CYS SER ASN SER GLY ASN ASP LEU GLU          
SEQRES  24 C  412  GLU CYS LEU LYS PHE LEU ASN PHE PHE LYS ASP ASN THR          
SEQRES  25 C  412  CYS LEU LYS ASN ALA ILE GLN ALA PHE GLY ASN GLY SER          
SEQRES  26 C  412  ASP VAL THR VAL TRP GLN PRO ALA PHE PRO VAL GLN THR          
SEQRES  27 C  412  THR THR ALA THR THR THR THR ALA LEU ARG VAL LYS ASN          
SEQRES  28 C  412  LYS PRO LEU GLY PRO ALA GLY SER GLU ASN GLU ILE PRO          
SEQRES  29 C  412  THR HIS VAL LEU PRO PRO CYS ALA ASN LEU GLN ALA GLN          
SEQRES  30 C  412  LYS LEU LYS SER ASN VAL SER GLY ASN THR HIS LEU CYS          
SEQRES  31 C  412  ILE SER ASN GLY ASN TYR GLU LYS GLU GLY LEU GLY GLY          
SEQRES  32 C  412  THR HIS HIS HIS HIS HIS HIS HIS HIS                          
SEQRES   1 E  617  LEU TYR PHE SER ARG ASP ALA TYR TRP GLU LYS LEU TYR          
SEQRES   2 E  617  VAL ASP GLN ALA ALA GLY THR PRO LEU LEU TYR VAL HIS          
SEQRES   3 E  617  ALA LEU ARG ASP ALA PRO GLU GLU VAL PRO SER PHE ARG          
SEQRES   4 E  617  LEU GLY GLN HIS LEU TYR GLY THR TYR ARG THR ARG LEU          
SEQRES   5 E  617  HIS GLU ASN ASN TRP ILE CYS ILE GLN GLU ASP THR GLY          
SEQRES   6 E  617  LEU LEU TYR LEU ASN ARG SER LEU ASP HIS SER SER TRP          
SEQRES   7 E  617  GLU LYS LEU SER VAL ARG ASN HIS GLY PHE PRO LEU LEU          
SEQRES   8 E  617  THR VAL TYR LEU LYS VAL PHE LEU SER PRO THR SER LEU          
SEQRES   9 E  617  ARG GLU GLY GLU CYS GLN TRP PRO GLY CYS ALA ARG VAL          
SEQRES  10 E  617  TYR PHE SER PHE PHE ASN THR SER PHE PRO ALA CYS SER          
SEQRES  11 E  617  SER LEU LYS PRO ARG GLU LEU CYS PHE PRO GLU THR ARG          
SEQRES  12 E  617  PRO SER PHE ARG ILE ARG GLU ASN ARG PRO PRO GLY THR          
SEQRES  13 E  617  PHE HIS GLN PHE ARG LEU LEU PRO VAL GLN PHE LEU CYS          
SEQRES  14 E  617  PRO ASN ILE SER VAL ALA TYR ARG LEU LEU GLU GLY GLU          
SEQRES  15 E  617  GLY LEU PRO PHE ARG CYS ALA PRO ASP SER LEU GLU VAL          
SEQRES  16 E  617  SER THR ARG TRP ALA LEU ASP ARG GLU GLN ARG GLU LYS          
SEQRES  17 E  617  TYR GLU LEU VAL ALA VAL CYS THR VAL HIS ALA GLY ALA          
SEQRES  18 E  617  ARG GLU GLU VAL VAL MET VAL PRO PHE PRO VAL THR VAL          
SEQRES  19 E  617  TYR ASP GLU ASP ASP SER ALA PRO THR PHE PRO ALA GLY          
SEQRES  20 E  617  VAL ASP THR ALA SER ALA VAL VAL GLU PHE LYS ARG LYS          
SEQRES  21 E  617  GLU ASP THR VAL VAL ALA THR LEU ARG VAL PHE ASP ALA          
SEQRES  22 E  617  ASP VAL VAL PRO ALA SER GLY GLU LEU VAL ARG ARG TYR          
SEQRES  23 E  617  THR SER THR LEU LEU PRO GLY ASP THR TRP ALA GLN GLN          
SEQRES  24 E  617  THR PHE ARG VAL GLU HIS TRP PRO ASN GLU THR SER VAL          
SEQRES  25 E  617  GLN ALA ASN GLY SER PHE VAL ARG ALA THR VAL HIS ASP          
SEQRES  26 E  617  TYR ARG LEU VAL LEU ASN ARG ASN LEU SER ILE SER GLU          
SEQRES  27 E  617  ASN ARG THR MET GLN LEU ALA VAL LEU VAL ASN ASP SER          
SEQRES  28 E  617  ASP PHE GLN GLY PRO GLY ALA GLY VAL LEU LEU LEU HIS          
SEQRES  29 E  617  PHE ASN VAL SER VAL LEU PRO VAL SER LEU HIS LEU PRO          
SEQRES  30 E  617  SER THR TYR SER LEU SER VAL SER ARG ARG ALA ARG ARG          
SEQRES  31 E  617  PHE ALA GLN ILE GLY LYS VAL CYS VAL GLU ASN CYS GLN          
SEQRES  32 E  617  ALA PHE SER GLY ILE ASN VAL GLN TYR LYS LEU HIS SER          
SEQRES  33 E  617  SER GLY ALA ASN CYS SER THR LEU GLY VAL VAL THR SER          
SEQRES  34 E  617  ALA GLU ASP THR SER GLY ILE LEU PHE VAL ASN ASP THR          
SEQRES  35 E  617  LYS ALA LEU ARG ARG PRO LYS CYS ALA GLU LEU HIS TYR          
SEQRES  36 E  617  MET VAL VAL ALA THR ASP GLN GLN THR SER ARG GLN ALA          
SEQRES  37 E  617  GLN ALA GLN LEU LEU VAL THR VAL GLU GLY SER TYR VAL          
SEQRES  38 E  617  ALA GLU GLU ALA GLY CYS PRO LEU SER CYS ALA VAL SER          
SEQRES  39 E  617  LYS ARG ARG LEU GLU CYS GLU GLU CYS GLY GLY LEU GLY          
SEQRES  40 E  617  SER PRO THR GLY ARG CYS GLU TRP ARG GLN GLY ASP GLY          
SEQRES  41 E  617  LYS GLY ILE THR ARG ASN PHE SER THR CYS SER PRO SER          
SEQRES  42 E  617  THR LYS THR CYS PRO ASP GLY HIS CYS ASP VAL VAL GLU          
SEQRES  43 E  617  THR GLN ASP ILE ASN ILE CYS PRO GLN ASP CYS LEU ARG          
SEQRES  44 E  617  GLY SER ILE VAL GLY GLY HIS GLU PRO GLY GLU PRO ARG          
SEQRES  45 E  617  GLY ILE LYS ALA GLY TYR GLY THR CYS ASN CYS PHE PRO          
SEQRES  46 E  617  GLU GLU GLU LYS CYS PHE CYS GLU PRO GLU ASP ILE GLN          
SEQRES  47 E  617  ASP PRO LEU CYS ASP GLU LEU CYS ARG GLY THR HIS HIS          
SEQRES  48 E  617  HIS HIS HIS HIS HIS HIS                                      
SEQRES   1 B  134  SER PRO ASP LYS GLN MET ALA VAL LEU PRO ARG ARG GLU          
SEQRES   2 B  134  ARG ASN ARG GLN ALA ALA ALA ALA ASN PRO GLU ASN SER          
SEQRES   3 B  134  ARG GLY LYS GLY ARG ARG GLY GLN ARG GLY LYS ASN ARG          
SEQRES   4 B  134  GLY CYS VAL LEU THR ALA ILE HIS LEU ASN VAL THR ASP          
SEQRES   5 B  134  LEU GLY LEU GLY TYR GLU THR LYS GLU GLU LEU ILE PHE          
SEQRES   6 B  134  ARG TYR CYS SER GLY SER CYS ASP ALA ALA GLU THR THR          
SEQRES   7 B  134  TYR ASP LYS ILE LEU LYS ASN LEU SER ARG ASN ARG ARG          
SEQRES   8 B  134  LEU VAL SER ASP LYS VAL GLY GLN ALA CYS CYS ARG PRO          
SEQRES   9 B  134  ILE ALA PHE ASP ASP ASP LEU SER PHE LEU ASP ASP ASN          
SEQRES  10 B  134  LEU VAL TYR HIS ILE LEU ARG LYS HIS SER ALA LYS ARG          
SEQRES  11 B  134  CYS GLY CYS ILE                                              
SEQRES   1 D  412  ASP ARG LEU ASP CYS VAL LYS ALA SER ASP GLN CYS LEU          
SEQRES   2 D  412  LYS GLU GLN SER CYS SER THR LYS TYR ARG THR LEU ARG          
SEQRES   3 D  412  GLN CYS VAL ALA GLY LYS GLU THR ASN PHE SER LEU ALA          
SEQRES   4 D  412  SER GLY LEU GLU ALA LYS ASP GLU CYS ARG SER ALA MET          
SEQRES   5 D  412  GLU ALA LEU LYS GLN LYS SER LEU TYR ASN CYS ARG CYS          
SEQRES   6 D  412  LYS ARG GLY MET LYS LYS GLU LYS ASN CYS LEU ARG ILE          
SEQRES   7 D  412  TYR TRP SER MET TYR GLN SER LEU GLN GLY ASN ASP LEU          
SEQRES   8 D  412  LEU GLU ASP SER PRO TYR GLU PRO VAL ASN SER ARG LEU          
SEQRES   9 D  412  SER ASP ILE PHE ARG VAL VAL PRO PHE ILE SER ASP VAL          
SEQRES  10 D  412  PHE GLN GLN VAL GLU HIS ILE PRO LYS GLY ASN ASN CYS          
SEQRES  11 D  412  LEU ASP ALA ALA LYS ALA CYS ASN LEU ASP ASP ILE CYS          
SEQRES  12 D  412  LYS LYS TYR ARG SER ALA TYR ILE THR PRO CYS THR THR          
SEQRES  13 D  412  SER VAL SER ASN ASP VAL CYS ASN ARG ARG LYS CYS HIS          
SEQRES  14 D  412  LYS ALA LEU ARG GLN PHE PHE ASP LYS VAL PRO ALA LYS          
SEQRES  15 D  412  HIS SER TYR GLY MET LEU PHE CYS SER CYS ARG ASP ILE          
SEQRES  16 D  412  ALA CYS THR GLU ARG ARG ARG GLN THR ILE VAL PRO VAL          
SEQRES  17 D  412  CYS SER TYR GLU GLU ARG GLU LYS PRO ASN CYS LEU ASN          
SEQRES  18 D  412  LEU GLN ASP SER CYS LYS THR ASN TYR ILE CYS ARG SER          
SEQRES  19 D  412  ARG LEU ALA ASP PHE PHE THR ASN CYS GLN PRO GLU SER          
SEQRES  20 D  412  ARG SER VAL SER SER CYS LEU LYS GLU ASN TYR ALA ASP          
SEQRES  21 D  412  CYS LEU LEU ALA TYR SER GLY LEU ILE GLY THR VAL MET          
SEQRES  22 D  412  THR PRO ASN TYR ILE ASP SER SER SER LEU SER VAL ALA          
SEQRES  23 D  412  PRO TRP CYS ASP CYS SER ASN SER GLY ASN ASP LEU GLU          
SEQRES  24 D  412  GLU CYS LEU LYS PHE LEU ASN PHE PHE LYS ASP ASN THR          
SEQRES  25 D  412  CYS LEU LYS ASN ALA ILE GLN ALA PHE GLY ASN GLY SER          
SEQRES  26 D  412  ASP VAL THR VAL TRP GLN PRO ALA PHE PRO VAL GLN THR          
SEQRES  27 D  412  THR THR ALA THR THR THR THR ALA LEU ARG VAL LYS ASN          
SEQRES  28 D  412  LYS PRO LEU GLY PRO ALA GLY SER GLU ASN GLU ILE PRO          
SEQRES  29 D  412  THR HIS VAL LEU PRO PRO CYS ALA ASN LEU GLN ALA GLN          
SEQRES  30 D  412  LYS LEU LYS SER ASN VAL SER GLY ASN THR HIS LEU CYS          
SEQRES  31 D  412  ILE SER ASN GLY ASN TYR GLU LYS GLU GLY LEU GLY GLY          
SEQRES  32 D  412  THR HIS HIS HIS HIS HIS HIS HIS HIS                          
SEQRES   1 F  617  LEU TYR PHE SER ARG ASP ALA TYR TRP GLU LYS LEU TYR          
SEQRES   2 F  617  VAL ASP GLN ALA ALA GLY THR PRO LEU LEU TYR VAL HIS          
SEQRES   3 F  617  ALA LEU ARG ASP ALA PRO GLU GLU VAL PRO SER PHE ARG          
SEQRES   4 F  617  LEU GLY GLN HIS LEU TYR GLY THR TYR ARG THR ARG LEU          
SEQRES   5 F  617  HIS GLU ASN ASN TRP ILE CYS ILE GLN GLU ASP THR GLY          
SEQRES   6 F  617  LEU LEU TYR LEU ASN ARG SER LEU ASP HIS SER SER TRP          
SEQRES   7 F  617  GLU LYS LEU SER VAL ARG ASN HIS GLY PHE PRO LEU LEU          
SEQRES   8 F  617  THR VAL TYR LEU LYS VAL PHE LEU SER PRO THR SER LEU          
SEQRES   9 F  617  ARG GLU GLY GLU CYS GLN TRP PRO GLY CYS ALA ARG VAL          
SEQRES  10 F  617  TYR PHE SER PHE PHE ASN THR SER PHE PRO ALA CYS SER          
SEQRES  11 F  617  SER LEU LYS PRO ARG GLU LEU CYS PHE PRO GLU THR ARG          
SEQRES  12 F  617  PRO SER PHE ARG ILE ARG GLU ASN ARG PRO PRO GLY THR          
SEQRES  13 F  617  PHE HIS GLN PHE ARG LEU LEU PRO VAL GLN PHE LEU CYS          
SEQRES  14 F  617  PRO ASN ILE SER VAL ALA TYR ARG LEU LEU GLU GLY GLU          
SEQRES  15 F  617  GLY LEU PRO PHE ARG CYS ALA PRO ASP SER LEU GLU VAL          
SEQRES  16 F  617  SER THR ARG TRP ALA LEU ASP ARG GLU GLN ARG GLU LYS          
SEQRES  17 F  617  TYR GLU LEU VAL ALA VAL CYS THR VAL HIS ALA GLY ALA          
SEQRES  18 F  617  ARG GLU GLU VAL VAL MET VAL PRO PHE PRO VAL THR VAL          
SEQRES  19 F  617  TYR ASP GLU ASP ASP SER ALA PRO THR PHE PRO ALA GLY          
SEQRES  20 F  617  VAL ASP THR ALA SER ALA VAL VAL GLU PHE LYS ARG LYS          
SEQRES  21 F  617  GLU ASP THR VAL VAL ALA THR LEU ARG VAL PHE ASP ALA          
SEQRES  22 F  617  ASP VAL VAL PRO ALA SER GLY GLU LEU VAL ARG ARG TYR          
SEQRES  23 F  617  THR SER THR LEU LEU PRO GLY ASP THR TRP ALA GLN GLN          
SEQRES  24 F  617  THR PHE ARG VAL GLU HIS TRP PRO ASN GLU THR SER VAL          
SEQRES  25 F  617  GLN ALA ASN GLY SER PHE VAL ARG ALA THR VAL HIS ASP          
SEQRES  26 F  617  TYR ARG LEU VAL LEU ASN ARG ASN LEU SER ILE SER GLU          
SEQRES  27 F  617  ASN ARG THR MET GLN LEU ALA VAL LEU VAL ASN ASP SER          
SEQRES  28 F  617  ASP PHE GLN GLY PRO GLY ALA GLY VAL LEU LEU LEU HIS          
SEQRES  29 F  617  PHE ASN VAL SER VAL LEU PRO VAL SER LEU HIS LEU PRO          
SEQRES  30 F  617  SER THR TYR SER LEU SER VAL SER ARG ARG ALA ARG ARG          
SEQRES  31 F  617  PHE ALA GLN ILE GLY LYS VAL CYS VAL GLU ASN CYS GLN          
SEQRES  32 F  617  ALA PHE SER GLY ILE ASN VAL GLN TYR LYS LEU HIS SER          
SEQRES  33 F  617  SER GLY ALA ASN CYS SER THR LEU GLY VAL VAL THR SER          
SEQRES  34 F  617  ALA GLU ASP THR SER GLY ILE LEU PHE VAL ASN ASP THR          
SEQRES  35 F  617  LYS ALA LEU ARG ARG PRO LYS CYS ALA GLU LEU HIS TYR          
SEQRES  36 F  617  MET VAL VAL ALA THR ASP GLN GLN THR SER ARG GLN ALA          
SEQRES  37 F  617  GLN ALA GLN LEU LEU VAL THR VAL GLU GLY SER TYR VAL          
SEQRES  38 F  617  ALA GLU GLU ALA GLY CYS PRO LEU SER CYS ALA VAL SER          
SEQRES  39 F  617  LYS ARG ARG LEU GLU CYS GLU GLU CYS GLY GLY LEU GLY          
SEQRES  40 F  617  SER PRO THR GLY ARG CYS GLU TRP ARG GLN GLY ASP GLY          
SEQRES  41 F  617  LYS GLY ILE THR ARG ASN PHE SER THR CYS SER PRO SER          
SEQRES  42 F  617  THR LYS THR CYS PRO ASP GLY HIS CYS ASP VAL VAL GLU          
SEQRES  43 F  617  THR GLN ASP ILE ASN ILE CYS PRO GLN ASP CYS LEU ARG          
SEQRES  44 F  617  GLY SER ILE VAL GLY GLY HIS GLU PRO GLY GLU PRO ARG          
SEQRES  45 F  617  GLY ILE LYS ALA GLY TYR GLY THR CYS ASN CYS PHE PRO          
SEQRES  46 F  617  GLU GLU GLU LYS CYS PHE CYS GLU PRO GLU ASP ILE GLN          
SEQRES  47 F  617  ASP PRO LEU CYS ASP GLU LEU CYS ARG GLY THR HIS HIS          
SEQRES  48 F  617  HIS HIS HIS HIS HIS HIS                                      
HET     CA  E2001       1                                                       
HET     CA  E2002       1                                                       
HET     CA  E2003       1                                                       
HET     CA  E2004       1                                                       
HET     CA  F2001       1                                                       
HET     CA  F2002       1                                                       
HET     CA  F2003       1                                                       
HET     CA  F2004       1                                                       
HETNAM      CA CALCIUM ION                                                      
FORMUL   7   CA    8(CA 2+)                                                     
HELIX    1 AA1 THR A  154  SER A  164  1                                  11    
HELIX    2 AA2 ASN C  152  ASP C  164  1                                  13    
HELIX    3 AA3 ASP C  164  THR C  176  1                                  13    
HELIX    4 AA4 PRO C  177  THR C  179  5                                   3    
HELIX    5 AA5 ASN C  188  VAL C  203  1                                  16    
HELIX    6 AA6 PRO C  204  PHE C  213  1                                  10    
HELIX    7 AA7 ASP C  218  GLN C  227  1                                  10    
HELIX    8 AA8 VAL C  230  TYR C  235  1                                   6    
HELIX    9 AA9 ASN C  242  THR C  252  1                                  11    
HELIX   10 AB1 ASN C  253  CYS C  267  1                                  15    
HELIX   11 AB2 ASN C  281  SER C  290  1                                  10    
HELIX   12 AB3 ASP C  321  ASP C  334  1                                  14    
HELIX   13 AB4 ASN C  335  GLY C  348  1                                  14    
HELIX   14 AB5 ASP E  102  VAL E  111  1                                  10    
HELIX   15 AB6 ALA E  156  LEU E  160  5                                   5    
HELIX   16 AB7 PRO E  162  PHE E  167  1                                   6    
HELIX   17 AB8 LEU E  190  CYS E  197  1                                   8    
HELIX   18 AB9 GLU E  309  TYR E  314  1                                   6    
HELIX   19 AC1 THR E  323  THR E  328  1                                   6    
HELIX   20 AC2 ASN E  429  PHE E  433  5                                   5    
HELIX   21 AC3 ARG E  524  GLU E  530  1                                   7    
HELIX   22 AC4 THR E  564  GLY E  568  5                                   5    
HELIX   23 AC5 THR B  154  SER B  164  1                                  11    
HELIX   24 AC6 ASN D  152  ASP D  164  1                                  13    
HELIX   25 AC7 ASP D  164  THR D  176  1                                  13    
HELIX   26 AC8 PRO D  177  THR D  179  5                                   3    
HELIX   27 AC9 ASN D  188  VAL D  203  1                                  16    
HELIX   28 AD1 PRO D  204  PHE D  213  1                                  10    
HELIX   29 AD2 ASP D  218  GLN D  227  1                                  10    
HELIX   30 AD3 VAL D  230  TYR D  235  1                                   6    
HELIX   31 AD4 ASN D  242  THR D  252  1                                  11    
HELIX   32 AD5 ASN D  253  CYS D  267  1                                  15    
HELIX   33 AD6 ASN D  281  SER D  290  1                                  10    
HELIX   34 AD7 ASP D  321  ASP D  334  1                                  14    
HELIX   35 AD8 ASN D  335  GLY D  348  1                                  14    
HELIX   36 AD9 ASP F  102  VAL F  111  1                                  10    
HELIX   37 AE1 ALA F  156  LEU F  160  5                                   5    
HELIX   38 AE2 PRO F  162  PHE F  167  1                                   6    
HELIX   39 AE3 LEU F  190  CYS F  197  1                                   8    
HELIX   40 AE4 GLU F  309  TYR F  314  1                                   6    
HELIX   41 AE5 THR F  323  THR F  328  1                                   6    
HELIX   42 AE6 ASN F  429  PHE F  433  5                                   5    
HELIX   43 AE7 ARG F  524  GLU F  530  1                                   7    
HELIX   44 AE8 THR F  564  GLY F  568  5                                   5    
SHEET    1 AA1 2 VAL A 119  ASN A 126  0                                        
SHEET    2 AA1 2 GLU A 139  SER A 146 -1  O  SER A 146   N  VAL A 119           
SHEET    1 AA2 2 ARG A 180  PRO A 181  0                                        
SHEET    2 AA2 2 CYS A 208  GLY A 209 -1  O  GLY A 209   N  ARG A 180           
SHEET    1 AA3 2 PHE A 190  LEU A 191  0                                        
SHEET    2 AA3 2 TYR A 197  HIS A 198 -1  O  HIS A 198   N  PHE A 190           
SHEET    1 AA4 2 ASN C 300  TYR C 301  0                                        
SHEET    2 AA4 2 VAL C 309  ALA C 310 -1  O  ALA C 310   N  ASN C 300           
SHEET    1 AA5 2 TYR E  30  PHE E  31  0                                        
SHEET    2 AA5 2 ALA E  55  LEU E  56 -1  O  LEU E  56   N  TYR E  30           
SHEET    1 AA6 3 ALA E  35  TYR E  36  0                                        
SHEET    2 AA6 3 CYS E 142  SER E 153  1  O  TYR E 146   N  TYR E  36           
SHEET    3 AA6 3 VAL E 121  TYR E 122 -1  N  VAL E 121   O  PHE E 147           
SHEET    1 AA7 3 LYS E  39  VAL E  42  0                                        
SHEET    2 AA7 3 CYS E 142  SER E 153  1  O  SER E 148   N  LEU E  40           
SHEET    3 AA7 3 VAL E 125  PHE E 126 -1  N  VAL E 125   O  ALA E 143           
SHEET    1 AA8 2 HIS E  71  TYR E  73  0                                        
SHEET    2 AA8 2 ARG E  79  GLU E  82 -1  O  HIS E  81   N  LEU E  72           
SHEET    1 AA9 2 ILE E  86  GLN E  89  0                                        
SHEET    2 AA9 2 LEU E  94  LEU E  97 -1  O  TYR E  96   N  CYS E  87           
SHEET    1 AB1 4 PHE E 174  ILE E 176  0                                        
SHEET    2 AB1 4 GLU E 252  VAL E 262  1  O  THR E 261   N  ILE E 176           
SHEET    3 AB1 4 LYS E 236  VAL E 245 -1  N  VAL E 245   O  GLU E 252           
SHEET    4 AB1 4 VAL E 202  LEU E 206 -1  N  ALA E 203   O  THR E 244           
SHEET    1 AB2 3 THR E 184  GLN E 187  0                                        
SHEET    2 AB2 3 GLU E 222  THR E 225 -1  O  VAL E 223   N  HIS E 186           
SHEET    3 AB2 3 PHE E 214  CYS E 216 -1  N  ARG E 215   O  SER E 224           
SHEET    1 AB3 4 SER E 280  VAL E 283  0                                        
SHEET    2 AB3 4 LEU E 389  VAL E 397  1  O  SER E 396   N  VAL E 283           
SHEET    3 AB3 4 ARG E 368  VAL E 376 -1  N  MET E 370   O  VAL E 395           
SHEET    4 AB3 4 SER E 316  LEU E 319 -1  N  THR E 317   O  LEU E 375           
SHEET    1 AB4 3 VAL E 292  VAL E 298  0                                        
SHEET    2 AB4 3 PHE E 346  LEU E 358 -1  O  LEU E 356   N  VAL E 293           
SHEET    3 AB4 3 PHE E 329  GLN E 341 -1  N  THR E 338   O  ALA E 349           
SHEET    1 AB5 4 THR E 407  VAL E 412  0                                        
SHEET    2 AB5 4 ALA E 496  VAL E 504  1  O  THR E 503   N  LEU E 410           
SHEET    3 AB5 4 HIS E 482  ASP E 489 -1  N  ALA E 487   O  ALA E 496           
SHEET    4 AB5 4 VAL E 438  SER E 445 -1  N  LYS E 441   O  VAL E 486           
SHEET    1 AB6 3 LYS E 424  VAL E 425  0                                        
SHEET    2 AB6 3 SER E 462  VAL E 467 -1  O  GLY E 463   N  VAL E 425           
SHEET    3 AB6 3 LEU E 452  SER E 457 -1  N  GLY E 453   O  PHE E 466           
SHEET    1 AB7 2 GLU E 542  ARG E 544  0                                        
SHEET    2 AB7 2 THR E 557  SER E 559 -1  O  THR E 557   N  ARG E 544           
SHEET    1 AB8 2 HIS E 594  PRO E 596  0                                        
SHEET    2 AB8 2 ILE E 602  GLY E 605 -1  O  ALA E 604   N  GLU E 595           
SHEET    1 AB9 2 THR E 608  PHE E 612  0                                        
SHEET    2 AB9 2 LYS E 617  GLU E 621 -1  O  GLU E 621   N  THR E 608           
SHEET    1 AC1 2 VAL B 119  ASN B 126  0                                        
SHEET    2 AC1 2 GLU B 139  SER B 146 -1  O  SER B 146   N  VAL B 119           
SHEET    1 AC2 2 ARG B 180  PRO B 181  0                                        
SHEET    2 AC2 2 CYS B 208  GLY B 209 -1  O  GLY B 209   N  ARG B 180           
SHEET    1 AC3 2 PHE B 190  LEU B 191  0                                        
SHEET    2 AC3 2 TYR B 197  HIS B 198 -1  O  HIS B 198   N  PHE B 190           
SHEET    1 AC4 2 ASN D 300  TYR D 301  0                                        
SHEET    2 AC4 2 VAL D 309  ALA D 310 -1  O  ALA D 310   N  ASN D 300           
SHEET    1 AC5 2 TYR F  30  PHE F  31  0                                        
SHEET    2 AC5 2 ALA F  55  LEU F  56 -1  O  LEU F  56   N  TYR F  30           
SHEET    1 AC6 3 ALA F  35  TYR F  36  0                                        
SHEET    2 AC6 3 CYS F 142  SER F 153  1  O  TYR F 146   N  TYR F  36           
SHEET    3 AC6 3 VAL F 121  TYR F 122 -1  N  VAL F 121   O  PHE F 147           
SHEET    1 AC7 3 LYS F  39  VAL F  42  0                                        
SHEET    2 AC7 3 CYS F 142  SER F 153  1  O  SER F 148   N  LEU F  40           
SHEET    3 AC7 3 VAL F 125  PHE F 126 -1  N  VAL F 125   O  ALA F 143           
SHEET    1 AC8 2 HIS F  71  TYR F  73  0                                        
SHEET    2 AC8 2 ARG F  79  GLU F  82 -1  O  LEU F  80   N  LEU F  72           
SHEET    1 AC9 2 ILE F  86  GLN F  89  0                                        
SHEET    2 AC9 2 LEU F  94  LEU F  97 -1  O  TYR F  96   N  CYS F  87           
SHEET    1 AD1 4 PHE F 174  ILE F 176  0                                        
SHEET    2 AD1 4 GLU F 252  VAL F 262  1  O  THR F 261   N  ILE F 176           
SHEET    3 AD1 4 LYS F 236  VAL F 245 -1  N  VAL F 245   O  GLU F 252           
SHEET    4 AD1 4 VAL F 202  LEU F 206 -1  N  ALA F 203   O  THR F 244           
SHEET    1 AD2 3 THR F 184  GLN F 187  0                                        
SHEET    2 AD2 3 GLU F 222  THR F 225 -1  O  VAL F 223   N  HIS F 186           
SHEET    3 AD2 3 PHE F 214  CYS F 216 -1  N  ARG F 215   O  SER F 224           
SHEET    1 AD3 4 SER F 280  VAL F 283  0                                        
SHEET    2 AD3 4 LEU F 389  VAL F 397  1  O  SER F 396   N  VAL F 283           
SHEET    3 AD3 4 ARG F 368  VAL F 376 -1  N  MET F 370   O  VAL F 395           
SHEET    4 AD3 4 SER F 316  LEU F 319 -1  N  THR F 317   O  LEU F 375           
SHEET    1 AD4 3 VAL F 292  VAL F 298  0                                        
SHEET    2 AD4 3 PHE F 346  LEU F 358 -1  O  LEU F 356   N  VAL F 293           
SHEET    3 AD4 3 PHE F 329  GLN F 341 -1  N  THR F 338   O  ALA F 349           
SHEET    1 AD5 4 THR F 407  VAL F 412  0                                        
SHEET    2 AD5 4 ALA F 496  VAL F 504  1  O  THR F 503   N  LEU F 410           
SHEET    3 AD5 4 HIS F 482  ASP F 489 -1  N  ALA F 487   O  ALA F 496           
SHEET    4 AD5 4 VAL F 438  SER F 445 -1  N  LYS F 441   O  VAL F 486           
SHEET    1 AD6 3 LYS F 424  VAL F 425  0                                        
SHEET    2 AD6 3 SER F 462  VAL F 467 -1  O  GLY F 463   N  VAL F 425           
SHEET    3 AD6 3 LEU F 452  SER F 457 -1  N  GLY F 453   O  PHE F 466           
SHEET    1 AD7 2 GLU F 542  ARG F 544  0                                        
SHEET    2 AD7 2 THR F 557  SER F 559 -1  O  THR F 557   N  ARG F 544           
SHEET    1 AD8 2 HIS F 594  PRO F 596  0                                        
SHEET    2 AD8 2 ILE F 602  GLY F 605 -1  O  ALA F 604   N  GLU F 595           
SHEET    1 AD9 2 THR F 608  PHE F 612  0                                        
SHEET    2 AD9 2 LYS F 617  GLU F 621 -1  O  GLU F 621   N  THR F 608           
SSBOND   1 CYS A  118    CYS A  179                          1555   1555  2.02  
SSBOND   2 CYS A  145    CYS A  208                          1555   1555  2.02  
SSBOND   3 CYS A  149    CYS A  210                          1555   1555  2.04  
SSBOND   4 CYS A  178    CYS B  178                          1555   1555  2.10  
SSBOND   5 CYS C  154    CYS C  214                          1555   1555  2.03  
SSBOND   6 CYS C  161    CYS C  167                          1555   1555  2.04  
SSBOND   7 CYS C  178    CYS C  192                          1555   1555  2.01  
SSBOND   8 CYS C  187    CYS C  233                          1555   1555  2.04  
SSBOND   9 CYS C  216    CYS C  221                          1555   1555  2.03  
SSBOND  10 CYS C  243    CYS C  313                          1555   1555  2.03  
SSBOND  11 CYS C  250    CYS C  256                          1555   1555  2.04  
SSBOND  12 CYS C  267    CYS C  285                          1555   1555  2.03  
SSBOND  13 CYS C  277    CYS C  337                          1555   1555  2.03  
SSBOND  14 CYS C  315    CYS C  325                          1555   1555  2.03  
SSBOND  15 CYS E  137    CYS E  142                          1555   1555  2.02  
SSBOND  16 CYS E  157    CYS E  197                          1555   1555  2.03  
SSBOND  17 CYS E  166    CYS E  243                          1555   1555  2.02  
SSBOND  18 CYS E  426    CYS E  430                          1555   1555  2.03  
SSBOND  19 CYS E  449    CYS E  478                          1555   1555  2.04  
SSBOND  20 CYS E  515    CYS E  531                          1555   1555  2.03  
SSBOND  21 CYS E  519    CYS E  541                          1555   1555  2.03  
SSBOND  22 CYS E  528    CYS E  558                          1555   1555  2.02  
SSBOND  23 CYS E  565    CYS E  581                          1555   1555  2.01  
SSBOND  24 CYS E  570    CYS E  585                          1555   1555  2.03  
SSBOND  25 CYS E  609    CYS E  620                          1555   1555  2.03  
SSBOND  26 CYS E  611    CYS E  618                          1555   1555  2.01  
SSBOND  27 CYS B  118    CYS B  179                          1555   1555  2.02  
SSBOND  28 CYS B  145    CYS B  208                          1555   1555  2.02  
SSBOND  29 CYS B  149    CYS B  210                          1555   1555  2.04  
SSBOND  30 CYS D  154    CYS D  214                          1555   1555  2.03  
SSBOND  31 CYS D  161    CYS D  167                          1555   1555  2.04  
SSBOND  32 CYS D  178    CYS D  192                          1555   1555  2.01  
SSBOND  33 CYS D  187    CYS D  233                          1555   1555  2.03  
SSBOND  34 CYS D  216    CYS D  221                          1555   1555  2.04  
SSBOND  35 CYS D  243    CYS D  313                          1555   1555  2.03  
SSBOND  36 CYS D  250    CYS D  256                          1555   1555  2.04  
SSBOND  37 CYS D  267    CYS D  285                          1555   1555  2.03  
SSBOND  38 CYS D  277    CYS D  337                          1555   1555  2.03  
SSBOND  39 CYS D  315    CYS D  325                          1555   1555  2.04  
SSBOND  40 CYS F  137    CYS F  142                          1555   1555  2.02  
SSBOND  41 CYS F  157    CYS F  197                          1555   1555  2.03  
SSBOND  42 CYS F  166    CYS F  243                          1555   1555  2.02  
SSBOND  43 CYS F  426    CYS F  430                          1555   1555  2.03  
SSBOND  44 CYS F  449    CYS F  478                          1555   1555  2.04  
SSBOND  45 CYS F  515    CYS F  531                          1555   1555  2.02  
SSBOND  46 CYS F  519    CYS F  541                          1555   1555  2.03  
SSBOND  47 CYS F  528    CYS F  558                          1555   1555  2.02  
SSBOND  48 CYS F  565    CYS F  581                          1555   1555  2.01  
SSBOND  49 CYS F  570    CYS F  585                          1555   1555  2.03  
SSBOND  50 CYS F  609    CYS F  620                          1555   1555  2.03  
SSBOND  51 CYS F  611    CYS F  618                          1555   1555  2.01  
LINK         OE1 GLU E 178                CA    CA E2003     1555   1555  2.48  
LINK         OE2 GLU E 178                CA    CA E2003     1555   1555  2.23  
LINK         OE2 GLU E 178                CA    CA E2002     1555   1555  2.43  
LINK         OD1 ASP E 230                CA    CA E2003     1555   1555  2.31  
LINK         OE1 GLU E 232                CA    CA E2003     1555   1555  2.26  
LINK         OE2 GLU E 232                CA    CA E2003     1555   1555  2.40  
LINK         OD1 ASP E 264                CA    CA E2002     1555   1555  2.33  
LINK         O   GLU E 265                CA    CA E2002     1555   1555  2.37  
LINK         OD1 ASP E 266                CA    CA E2001     1555   1555  2.37  
LINK         OD1 ASP E 267                CA    CA E2002     1555   1555  2.36  
LINK         OD2 ASP E 267                CA    CA E2003     1555   1555  2.27  
LINK         OD2 ASP E 267                CA    CA E2002     1555   1555  2.87  
LINK         O   SER E 268                CA    CA E2001     1555   1555  2.36  
LINK         OD1 ASP E 300                CA    CA E2001     1555   1555  2.59  
LINK         OD2 ASP E 300                CA    CA E2001     1555   1555  2.14  
LINK         OD2 ASP E 302                CA    CA E2001     1555   1555  2.27  
LINK         OD1 ASP E 378                CA    CA E2001     1555   1555  2.62  
LINK         OD2 ASP E 378                CA    CA E2001     1555   1555  2.38  
LINK         O   THR E 564                CA    CA E2004     1555   1555  2.07  
LINK         O   CYS E 565                CA    CA E2004     1555   1555  2.93  
LINK         OD1 ASP E 567                CA    CA E2004     1555   1555  2.42  
LINK         OD2 ASP E 567                CA    CA E2004     1555   1555  2.49  
LINK         O   HIS E 569                CA    CA E2004     1555   1555  2.35  
LINK         OE1 GLU E 574                CA    CA E2004     1555   1555  2.46  
LINK         OE2 GLU E 574                CA    CA E2004     1555   1555  2.54  
LINK         OD2 ASP E 584                CA    CA E2004     1555   1555  2.38  
LINK         OE1 GLU F 178                CA    CA F2003     1555   1555  2.48  
LINK         OE2 GLU F 178                CA    CA F2003     1555   1555  2.23  
LINK         OE2 GLU F 178                CA    CA F2002     1555   1555  2.43  
LINK         OD1 ASP F 230                CA    CA F2003     1555   1555  2.31  
LINK         OE1 GLU F 232                CA    CA F2003     1555   1555  2.26  
LINK         OE2 GLU F 232                CA    CA F2003     1555   1555  2.40  
LINK         OD1 ASP F 264                CA    CA F2002     1555   1555  2.33  
LINK         O   GLU F 265                CA    CA F2002     1555   1555  2.37  
LINK         OD1 ASP F 266                CA    CA F2001     1555   1555  2.37  
LINK         OD1 ASP F 267                CA    CA F2002     1555   1555  2.36  
LINK         OD2 ASP F 267                CA    CA F2003     1555   1555  2.27  
LINK         OD2 ASP F 267                CA    CA F2002     1555   1555  2.87  
LINK         O   SER F 268                CA    CA F2001     1555   1555  2.36  
LINK         OD1 ASP F 300                CA    CA F2001     1555   1555  2.59  
LINK         OD2 ASP F 300                CA    CA F2001     1555   1555  2.14  
LINK         OD2 ASP F 302                CA    CA F2001     1555   1555  2.27  
LINK         OD1 ASP F 378                CA    CA F2001     1555   1555  2.62  
LINK         OD2 ASP F 378                CA    CA F2001     1555   1555  2.38  
LINK         O   THR F 564                CA    CA F2004     1555   1555  2.07  
LINK         O   CYS F 565                CA    CA F2004     1555   1555  2.93  
LINK         OD1 ASP F 567                CA    CA F2004     1555   1555  2.42  
LINK         OD2 ASP F 567                CA    CA F2004     1555   1555  2.49  
LINK         O   HIS F 569                CA    CA F2004     1555   1555  2.35  
LINK         OE1 GLU F 574                CA    CA F2004     1555   1555  2.46  
LINK         OE2 GLU F 574                CA    CA F2004     1555   1555  2.54  
LINK         OD2 ASP F 584                CA    CA F2004     1555   1555  2.38  
CISPEP   1 TRP E  139    PRO E  140          0        -2.22                     
CISPEP   2 TRP F  139    PRO F  140          0        -2.22                     
SITE     1 AC1  5 ASP E 266  SER E 268  ASP E 300  ASP E 302                    
SITE     2 AC1  5 ASP E 378                                                     
SITE     1 AC2  6 GLU E 178  GLU E 232  ASP E 264  GLU E 265                    
SITE     2 AC2  6 ASP E 267   CA E2003                                          
SITE     1 AC3  7 GLU E 178  ASN E 179  ASP E 230  GLU E 232                    
SITE     2 AC3  7 ASP E 264  ASP E 267   CA E2002                               
SITE     1 AC4  6 THR E 564  CYS E 565  ASP E 567  HIS E 569                    
SITE     2 AC4  6 GLU E 574  ASP E 584                                          
SITE     1 AC5  5 ASP F 266  SER F 268  ASP F 300  ASP F 302                    
SITE     2 AC5  5 ASP F 378                                                     
SITE     1 AC6  6 GLU F 178  GLU F 232  ASP F 264  GLU F 265                    
SITE     2 AC6  6 ASP F 267   CA F2003                                          
SITE     1 AC7  7 GLU F 178  ASN F 179  ASP F 230  GLU F 232                    
SITE     2 AC7  7 ASP F 264  ASP F 267   CA F2002                               
SITE     1 AC8  6 THR F 564  CYS F 565  ASP F 567  HIS F 569                    
SITE     2 AC8  6 GLU F 574  ASP F 584                                          
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1                      
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      1.000000  0.000000  0.000000        0.00000                         
SCALE2      0.000000  1.000000  0.000000        0.00000                         
SCALE3      0.000000  0.000000  1.000000        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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