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Database: PDB
Entry: 6Q2S
LinkDB: 6Q2S
Original site: 6Q2S 
HEADER    SIGNALING PROTEIN                       08-AUG-19   6Q2S              
TITLE     CRYO-EM STRUCTURE OF RET/GFRA3/ARTN EXTRACELLULAR COMPLEX. THE 3D     
TITLE    2 REFINEMENT WAS APPLIED WITH C2 SYMMETRY.                             
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: UBIQUITIN-LIKE PROTEIN SMT3,ARTEMIN;                       
COMPND   3 CHAIN: A, B;                                                         
COMPND   4 SYNONYM: ENOVIN,NEUBLASTIN;                                          
COMPND   5 ENGINEERED: YES;                                                     
COMPND   6 OTHER_DETAILS: A SUMO PROTEIN WAS FUSED TO THE N-TERMINAL OF NRTN FOR
COMPND   7 THE PROTEIN EXPRESSION;                                              
COMPND   8 MOL_ID: 2;                                                           
COMPND   9 MOLECULE: GDNF FAMILY RECEPTOR ALPHA-3;                              
COMPND  10 CHAIN: C, D;                                                         
COMPND  11 SYNONYM: GFR-ALPHA-3;                                                
COMPND  12 ENGINEERED: YES;                                                     
COMPND  13 MOL_ID: 3;                                                           
COMPND  14 MOLECULE: PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET;       
COMPND  15 CHAIN: E, F;                                                         
COMPND  16 SYNONYM: CADHERIN FAMILY MEMBER 12,PROTO-ONCOGENE C-RET;             
COMPND  17 EC: 2.7.10.1;                                                        
COMPND  18 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: SACCHAROMYCES CEREVISIAE, HOMO SAPIENS;         
SOURCE   3 ORGANISM_COMMON: BAKER'S YEAST, HUMAN;                               
SOURCE   4 ORGANISM_TAXID: 4932, 9606;                                          
SOURCE   5 GENE: SMT3, ARTN, EVN;                                               
SOURCE   6 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE   8 MOL_ID: 2;                                                           
SOURCE   9 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  10 ORGANISM_COMMON: HUMAN;                                              
SOURCE  11 ORGANISM_TAXID: 9606;                                                
SOURCE  12 GENE: GFRA3, UNQ339/PRO538/PRO3664;                                  
SOURCE  13 EXPRESSION_SYSTEM: HOMO SAPIENS;                                     
SOURCE  14 EXPRESSION_SYSTEM_COMMON: HUMAN;                                     
SOURCE  15 EXPRESSION_SYSTEM_TAXID: 9606;                                       
SOURCE  16 EXPRESSION_SYSTEM_CELL_LINE: HEK293;                                 
SOURCE  17 MOL_ID: 3;                                                           
SOURCE  18 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  19 ORGANISM_COMMON: HUMAN;                                              
SOURCE  20 ORGANISM_TAXID: 9606;                                                
SOURCE  21 GENE: RET, CDHF12, CDHR16, PTC, RET51;                               
SOURCE  22 EXPRESSION_SYSTEM: HOMO SAPIENS;                                     
SOURCE  23 EXPRESSION_SYSTEM_COMMON: HUMAN;                                     
SOURCE  24 EXPRESSION_SYSTEM_TAXID: 9606;                                       
SOURCE  25 EXPRESSION_SYSTEM_CELL_LINE: HEK293                                  
KEYWDS    RET, RECEPTOR TYROSINE KINASE, CRYO-EM, SIGNALING PROTEIN             
EXPDTA    ELECTRON MICROSCOPY                                                   
AUTHOR    J.LI,G.J.SHANG,Y.J.CHEN,C.A.BRAUTIGAM,J.LIOU,X.W.ZHANG,X.C.BAI        
REVDAT   2   29-JUL-20 6Q2S    1       COMPND REMARK HETNAM LINK                
REVDAT   2 2                   1       SITE                                     
REVDAT   1   02-OCT-19 6Q2S    0                                                
JRNL        AUTH   J.LI,G.SHANG,Y.J.CHEN,C.A.BRAUTIGAM,J.LIOU,X.ZHANG,X.C.BAI   
JRNL        TITL   CRYO-EM ANALYSES REVEAL THE COMMON MECHANISM AND             
JRNL        TITL 2 DIVERSIFICATION IN THE ACTIVATION OF RET BY DIFFERENT        
JRNL        TITL 3 LIGANDS.                                                     
JRNL        REF    ELIFE                         V.   8       2019              
JRNL        REFN                   ESSN 2050-084X                               
JRNL        PMID   31535977                                                     
JRNL        DOI    10.7554/ELIFE.47650                                          
REMARK   2                                                                      
REMARK   2 RESOLUTION.    3.80 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   SOFTWARE PACKAGES      : RELION, EPU, RELION, COOT, PHENIX,        
REMARK   3                            RELION, RELION, RELION, RELION            
REMARK   3   RECONSTRUCTION SCHEMA  : NULL                                      
REMARK   3                                                                      
REMARK   3 EM MAP-MODEL FITTING AND REFINEMENT                                  
REMARK   3   PDB ENTRY                    : NULL                                
REMARK   3   REFINEMENT SPACE             : REAL                                
REMARK   3   REFINEMENT PROTOCOL          : FLEXIBLE FIT                        
REMARK   3   REFINEMENT TARGET            : NULL                                
REMARK   3   OVERALL ANISOTROPIC B VALUE  : 190.000                             
REMARK   3                                                                      
REMARK   3 FITTING PROCEDURE : NULL                                             
REMARK   3                                                                      
REMARK   3 EM IMAGE RECONSTRUCTION STATISTICS                                   
REMARK   3   NOMINAL PIXEL SIZE (ANGSTROMS)    : NULL                           
REMARK   3   ACTUAL PIXEL SIZE  (ANGSTROMS)    : NULL                           
REMARK   3   EFFECTIVE RESOLUTION (ANGSTROMS)  : 3.800                          
REMARK   3   NUMBER OF PARTICLES               : 114344                         
REMARK   3   CTF CORRECTION METHOD             : PHASE FLIPPING AND AMPLITUDE   
REMARK   3                                       CORRECTION                     
REMARK   3                                                                      
REMARK   3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL                    
REMARK   3                                                                      
REMARK   3 OTHER DETAILS: NULL                                                  
REMARK   4                                                                      
REMARK   4 6Q2S COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 09-AUG-19.                  
REMARK 100 THE DEPOSITION ID IS D_1000243545.                                   
REMARK 245                                                                      
REMARK 245 EXPERIMENTAL DETAILS                                                 
REMARK 245   RECONSTRUCTION METHOD          : SINGLE PARTICLE                   
REMARK 245   SPECIMEN TYPE                  : NULL                              
REMARK 245                                                                      
REMARK 245 ELECTRON MICROSCOPE SAMPLE                                           
REMARK 245   SAMPLE TYPE                    : PARTICLE                          
REMARK 245   PARTICLE TYPE                  : POINT                             
REMARK 245   NAME OF SAMPLE                 : RET, GFRAL AND GDF15              
REMARK 245                                    EXTRACELLULAR COMPLEX             
REMARK 245   SAMPLE CONCENTRATION (MG ML-1) : 1.00                              
REMARK 245   SAMPLE SUPPORT DETAILS         : UNSPECIFIED                       
REMARK 245   SAMPLE VITRIFICATION DETAILS   : NULL                              
REMARK 245   SAMPLE BUFFER                  : NULL                              
REMARK 245   PH                             : 7.40                              
REMARK 245   SAMPLE DETAILS                 : NULL                              
REMARK 245                                                                      
REMARK 245 DATA ACQUISITION                                                     
REMARK 245   DATE OF EXPERIMENT                : NULL                           
REMARK 245   NUMBER OF MICROGRAPHS-IMAGES      : NULL                           
REMARK 245   TEMPERATURE (KELVIN)              : NULL                           
REMARK 245   MICROSCOPE MODEL                  : FEI TITAN KRIOS                
REMARK 245   DETECTOR TYPE                     : GATAN K2 QUANTUM (4K X 4K)     
REMARK 245   MINIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MAXIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MINIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   MAXIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   NOMINAL CS                        : 2.70                           
REMARK 245   IMAGING MODE                      : BRIGHT FIELD                   
REMARK 245   ELECTRON DOSE (ELECTRONS NM**-2)  : 50.00                          
REMARK 245   ILLUMINATION MODE                 : FLOOD BEAM                     
REMARK 245   NOMINAL MAGNIFICATION             : NULL                           
REMARK 245   CALIBRATED MAGNIFICATION          : 46729                          
REMARK 245   SOURCE                            : FIELD EMISSION GUN             
REMARK 245   ACCELERATION VOLTAGE (KV)         : 300                            
REMARK 245   IMAGING DETAILS                   : NULL                           
REMARK 247                                                                      
REMARK 247 ELECTRON MICROSCOPY                                                  
REMARK 247  THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON          
REMARK 247  MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE              
REMARK 247  THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES           
REMARK 247  ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION         
REMARK 247  OF THE STRUCTURE FACTORS.                                           
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: HEXAMERIC                         
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, C, E, B, D, F                      
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     MET A   -14                                                      
REMARK 465     GLY A   -13                                                      
REMARK 465     SER A   -12                                                      
REMARK 465     SER A   -11                                                      
REMARK 465     HIS A   -10                                                      
REMARK 465     HIS A    -9                                                      
REMARK 465     HIS A    -8                                                      
REMARK 465     HIS A    -7                                                      
REMARK 465     HIS A    -6                                                      
REMARK 465     HIS A    -5                                                      
REMARK 465     SER A    -4                                                      
REMARK 465     SER A    -3                                                      
REMARK 465     GLY A    -2                                                      
REMARK 465     LEU A    -1                                                      
REMARK 465     VAL A     0                                                      
REMARK 465     PRO A     1                                                      
REMARK 465     ARG A     2                                                      
REMARK 465     GLY A     3                                                      
REMARK 465     SER A     4                                                      
REMARK 465     HIS A     5                                                      
REMARK 465     MET A     6                                                      
REMARK 465     ALA A     7                                                      
REMARK 465     SER A     8                                                      
REMARK 465     MET A     9                                                      
REMARK 465     SER A    10                                                      
REMARK 465     ASP A    11                                                      
REMARK 465     SER A    12                                                      
REMARK 465     GLU A    13                                                      
REMARK 465     VAL A    14                                                      
REMARK 465     ASN A    15                                                      
REMARK 465     GLN A    16                                                      
REMARK 465     GLU A    17                                                      
REMARK 465     ALA A    18                                                      
REMARK 465     LYS A    19                                                      
REMARK 465     PRO A    20                                                      
REMARK 465     GLU A    21                                                      
REMARK 465     VAL A    22                                                      
REMARK 465     LYS A    23                                                      
REMARK 465     PRO A    24                                                      
REMARK 465     GLU A    25                                                      
REMARK 465     VAL A    26                                                      
REMARK 465     LYS A    27                                                      
REMARK 465     PRO A    28                                                      
REMARK 465     GLU A    29                                                      
REMARK 465     THR A    30                                                      
REMARK 465     HIS A    31                                                      
REMARK 465     ILE A    32                                                      
REMARK 465     ASN A    33                                                      
REMARK 465     LEU A    34                                                      
REMARK 465     LYS A    35                                                      
REMARK 465     VAL A    36                                                      
REMARK 465     SER A    37                                                      
REMARK 465     ASP A    38                                                      
REMARK 465     GLY A    39                                                      
REMARK 465     SER A    40                                                      
REMARK 465     SER A    41                                                      
REMARK 465     GLU A    42                                                      
REMARK 465     ILE A    43                                                      
REMARK 465     PHE A    44                                                      
REMARK 465     PHE A    45                                                      
REMARK 465     LYS A    46                                                      
REMARK 465     ILE A    47                                                      
REMARK 465     LYS A    48                                                      
REMARK 465     LYS A    49                                                      
REMARK 465     THR A    50                                                      
REMARK 465     THR A    51                                                      
REMARK 465     PRO A    52                                                      
REMARK 465     LEU A    53                                                      
REMARK 465     ARG A    54                                                      
REMARK 465     ARG A    55                                                      
REMARK 465     LEU A    56                                                      
REMARK 465     MET A    57                                                      
REMARK 465     GLU A    58                                                      
REMARK 465     ALA A    59                                                      
REMARK 465     PHE A    60                                                      
REMARK 465     ALA A    61                                                      
REMARK 465     LYS A    62                                                      
REMARK 465     ARG A    63                                                      
REMARK 465     GLN A    64                                                      
REMARK 465     GLY A    65                                                      
REMARK 465     LYS A    66                                                      
REMARK 465     GLU A    67                                                      
REMARK 465     MET A    68                                                      
REMARK 465     ASP A    69                                                      
REMARK 465     SER A    70                                                      
REMARK 465     LEU A    71                                                      
REMARK 465     ARG A    72                                                      
REMARK 465     PHE A    73                                                      
REMARK 465     LEU A    74                                                      
REMARK 465     TYR A    75                                                      
REMARK 465     ASP A    76                                                      
REMARK 465     GLY A    77                                                      
REMARK 465     ILE A    78                                                      
REMARK 465     ARG A    79                                                      
REMARK 465     ILE A    80                                                      
REMARK 465     GLN A    81                                                      
REMARK 465     ALA A    82                                                      
REMARK 465     ASP A    83                                                      
REMARK 465     GLN A    84                                                      
REMARK 465     THR A    85                                                      
REMARK 465     PRO A    86                                                      
REMARK 465     GLU A    87                                                      
REMARK 465     ASP A    88                                                      
REMARK 465     LEU A    89                                                      
REMARK 465     ASP A    90                                                      
REMARK 465     MET A    91                                                      
REMARK 465     GLU A    92                                                      
REMARK 465     ASP A    93                                                      
REMARK 465     ASN A    94                                                      
REMARK 465     ASP A    95                                                      
REMARK 465     ILE A    96                                                      
REMARK 465     ILE A    97                                                      
REMARK 465     GLU A    98                                                      
REMARK 465     ALA A    99                                                      
REMARK 465     HIS A   100                                                      
REMARK 465     ARG A   101                                                      
REMARK 465     GLU A   102                                                      
REMARK 465     GLN A   103                                                      
REMARK 465     ILE A   104                                                      
REMARK 465     GLY A   105                                                      
REMARK 465     GLY A   106                                                      
REMARK 465     SER A   107                                                      
REMARK 465     ALA A   108                                                      
REMARK 465     GLY A   109                                                      
REMARK 465     GLY A   110                                                      
REMARK 465     PRO A   111                                                      
REMARK 465     GLY A   112                                                      
REMARK 465     SER A   113                                                      
REMARK 465     ARG A   114                                                      
REMARK 465     ALA A   115                                                      
REMARK 465     ARG A   116                                                      
REMARK 465     ALA A   117                                                      
REMARK 465     ALA A   118                                                      
REMARK 465     GLY A   119                                                      
REMARK 465     ALA A   120                                                      
REMARK 465     ARG A   121                                                      
REMARK 465     GLY A   220                                                      
REMARK 465     ASP C    32                                                      
REMARK 465     PRO C    33                                                      
REMARK 465     LEU C    34                                                      
REMARK 465     PRO C    35                                                      
REMARK 465     THR C    36                                                      
REMARK 465     GLU C    37                                                      
REMARK 465     SER C    38                                                      
REMARK 465     ARG C    39                                                      
REMARK 465     LEU C    40                                                      
REMARK 465     MET C    41                                                      
REMARK 465     ASN C    42                                                      
REMARK 465     SER C    43                                                      
REMARK 465     CYS C    44                                                      
REMARK 465     LEU C    45                                                      
REMARK 465     GLN C    46                                                      
REMARK 465     ALA C    47                                                      
REMARK 465     ARG C    48                                                      
REMARK 465     ARG C    49                                                      
REMARK 465     LYS C    50                                                      
REMARK 465     CYS C    51                                                      
REMARK 465     GLN C    52                                                      
REMARK 465     ALA C    53                                                      
REMARK 465     ASP C    54                                                      
REMARK 465     PRO C    55                                                      
REMARK 465     THR C    56                                                      
REMARK 465     CYS C    57                                                      
REMARK 465     SER C    58                                                      
REMARK 465     ALA C    59                                                      
REMARK 465     ALA C    60                                                      
REMARK 465     TYR C    61                                                      
REMARK 465     HIS C    62                                                      
REMARK 465     HIS C    63                                                      
REMARK 465     LEU C    64                                                      
REMARK 465     ASP C    65                                                      
REMARK 465     SER C    66                                                      
REMARK 465     CYS C    67                                                      
REMARK 465     THR C    68                                                      
REMARK 465     SER C    69                                                      
REMARK 465     SER C    70                                                      
REMARK 465     ILE C    71                                                      
REMARK 465     SER C    72                                                      
REMARK 465     THR C    73                                                      
REMARK 465     PRO C    74                                                      
REMARK 465     LEU C    75                                                      
REMARK 465     PRO C    76                                                      
REMARK 465     SER C    77                                                      
REMARK 465     GLU C    78                                                      
REMARK 465     GLU C    79                                                      
REMARK 465     PRO C    80                                                      
REMARK 465     SER C    81                                                      
REMARK 465     VAL C    82                                                      
REMARK 465     PRO C    83                                                      
REMARK 465     ALA C    84                                                      
REMARK 465     ASP C    85                                                      
REMARK 465     CYS C    86                                                      
REMARK 465     LEU C    87                                                      
REMARK 465     GLU C    88                                                      
REMARK 465     ALA C    89                                                      
REMARK 465     ALA C    90                                                      
REMARK 465     GLN C    91                                                      
REMARK 465     GLN C    92                                                      
REMARK 465     LEU C    93                                                      
REMARK 465     ARG C    94                                                      
REMARK 465     ASN C    95                                                      
REMARK 465     SER C    96                                                      
REMARK 465     SER C    97                                                      
REMARK 465     LEU C    98                                                      
REMARK 465     ILE C    99                                                      
REMARK 465     GLY C   100                                                      
REMARK 465     CYS C   101                                                      
REMARK 465     MET C   102                                                      
REMARK 465     CYS C   103                                                      
REMARK 465     HIS C   104                                                      
REMARK 465     ARG C   105                                                      
REMARK 465     ARG C   106                                                      
REMARK 465     MET C   107                                                      
REMARK 465     LYS C   108                                                      
REMARK 465     ASN C   109                                                      
REMARK 465     GLN C   110                                                      
REMARK 465     VAL C   111                                                      
REMARK 465     ALA C   112                                                      
REMARK 465     CYS C   113                                                      
REMARK 465     LEU C   114                                                      
REMARK 465     ASP C   115                                                      
REMARK 465     ILE C   116                                                      
REMARK 465     TYR C   117                                                      
REMARK 465     TRP C   118                                                      
REMARK 465     THR C   119                                                      
REMARK 465     VAL C   120                                                      
REMARK 465     HIS C   121                                                      
REMARK 465     ARG C   122                                                      
REMARK 465     ALA C   123                                                      
REMARK 465     ARG C   124                                                      
REMARK 465     SER C   125                                                      
REMARK 465     LEU C   126                                                      
REMARK 465     GLY C   127                                                      
REMARK 465     ASN C   128                                                      
REMARK 465     TYR C   129                                                      
REMARK 465     GLU C   130                                                      
REMARK 465     LEU C   131                                                      
REMARK 465     ASP C   132                                                      
REMARK 465     VAL C   133                                                      
REMARK 465     SER C   134                                                      
REMARK 465     PRO C   135                                                      
REMARK 465     TYR C   136                                                      
REMARK 465     GLU C   137                                                      
REMARK 465     ASP C   138                                                      
REMARK 465     THR C   139                                                      
REMARK 465     VAL C   140                                                      
REMARK 465     THR C   141                                                      
REMARK 465     SER C   142                                                      
REMARK 465     LYS C   143                                                      
REMARK 465     PRO C   144                                                      
REMARK 465     TRP C   145                                                      
REMARK 465     LYS C   146                                                      
REMARK 465     MET C   147                                                      
REMARK 465     ASN C   148                                                      
REMARK 465     LEU C   149                                                      
REMARK 465     SER C   150                                                      
REMARK 465     LYS C   151                                                      
REMARK 465     LEU C   152                                                      
REMARK 465     ASN C   153                                                      
REMARK 465     MET C   154                                                      
REMARK 465     LEU C   155                                                      
REMARK 465     LYS C   156                                                      
REMARK 465     PRO C   157                                                      
REMARK 465     ASP C   158                                                      
REMARK 465     GLN C   358                                                      
REMARK 465     ASP C   359                                                      
REMARK 465     TRP C   360                                                      
REMARK 465     PRO C   361                                                      
REMARK 465     HIS C   362                                                      
REMARK 465     PRO C   363                                                      
REMARK 465     GLY C   364                                                      
REMARK 465     THR C   365                                                      
REMARK 465     HIS C   366                                                      
REMARK 465     HIS C   367                                                      
REMARK 465     HIS C   368                                                      
REMARK 465     HIS C   369                                                      
REMARK 465     HIS C   370                                                      
REMARK 465     HIS C   371                                                      
REMARK 465     HIS C   372                                                      
REMARK 465     HIS C   373                                                      
REMARK 465     PRO E   129                                                      
REMARK 465     THR E   130                                                      
REMARK 465     SER E   131                                                      
REMARK 465     LEU E   132                                                      
REMARK 465     ARG E   133                                                      
REMARK 465     GLU E   134                                                      
REMARK 465     GLU E   208                                                      
REMARK 465     GLY E   209                                                      
REMARK 465     GLU E   210                                                      
REMARK 465     ALA E   247                                                      
REMARK 465     GLY E   248                                                      
REMARK 465     ALA E   249                                                      
REMARK 465     ARG E   250                                                      
REMARK 465     ASP E   380                                                      
REMARK 465     PHE E   381                                                      
REMARK 465     GLN E   382                                                      
REMARK 465     GLY E   383                                                      
REMARK 465     PRO E   384                                                      
REMARK 465     GLY E   385                                                      
REMARK 465     ALA E   386                                                      
REMARK 465     GLY E   387                                                      
REMARK 465     GLY E   446                                                      
REMARK 465     ALA E   447                                                      
REMARK 465     ASN E   448                                                      
REMARK 465     GLU E   623                                                      
REMARK 465     ASP E   624                                                      
REMARK 465     ILE E   625                                                      
REMARK 465     GLN E   626                                                      
REMARK 465     ASP E   627                                                      
REMARK 465     PRO E   628                                                      
REMARK 465     LEU E   629                                                      
REMARK 465     CYS E   630                                                      
REMARK 465     ASP E   631                                                      
REMARK 465     GLU E   632                                                      
REMARK 465     LEU E   633                                                      
REMARK 465     CYS E   634                                                      
REMARK 465     ARG E   635                                                      
REMARK 465     GLY E   636                                                      
REMARK 465     THR E   637                                                      
REMARK 465     HIS E   638                                                      
REMARK 465     HIS E   639                                                      
REMARK 465     HIS E   640                                                      
REMARK 465     HIS E   641                                                      
REMARK 465     HIS E   642                                                      
REMARK 465     HIS E   643                                                      
REMARK 465     HIS E   644                                                      
REMARK 465     HIS E   645                                                      
REMARK 465     MET B   -14                                                      
REMARK 465     GLY B   -13                                                      
REMARK 465     SER B   -12                                                      
REMARK 465     SER B   -11                                                      
REMARK 465     HIS B   -10                                                      
REMARK 465     HIS B    -9                                                      
REMARK 465     HIS B    -8                                                      
REMARK 465     HIS B    -7                                                      
REMARK 465     HIS B    -6                                                      
REMARK 465     HIS B    -5                                                      
REMARK 465     SER B    -4                                                      
REMARK 465     SER B    -3                                                      
REMARK 465     GLY B    -2                                                      
REMARK 465     LEU B    -1                                                      
REMARK 465     VAL B     0                                                      
REMARK 465     PRO B     1                                                      
REMARK 465     ARG B     2                                                      
REMARK 465     GLY B     3                                                      
REMARK 465     SER B     4                                                      
REMARK 465     HIS B     5                                                      
REMARK 465     MET B     6                                                      
REMARK 465     ALA B     7                                                      
REMARK 465     SER B     8                                                      
REMARK 465     MET B     9                                                      
REMARK 465     SER B    10                                                      
REMARK 465     ASP B    11                                                      
REMARK 465     SER B    12                                                      
REMARK 465     GLU B    13                                                      
REMARK 465     VAL B    14                                                      
REMARK 465     ASN B    15                                                      
REMARK 465     GLN B    16                                                      
REMARK 465     GLU B    17                                                      
REMARK 465     ALA B    18                                                      
REMARK 465     LYS B    19                                                      
REMARK 465     PRO B    20                                                      
REMARK 465     GLU B    21                                                      
REMARK 465     VAL B    22                                                      
REMARK 465     LYS B    23                                                      
REMARK 465     PRO B    24                                                      
REMARK 465     GLU B    25                                                      
REMARK 465     VAL B    26                                                      
REMARK 465     LYS B    27                                                      
REMARK 465     PRO B    28                                                      
REMARK 465     GLU B    29                                                      
REMARK 465     THR B    30                                                      
REMARK 465     HIS B    31                                                      
REMARK 465     ILE B    32                                                      
REMARK 465     ASN B    33                                                      
REMARK 465     LEU B    34                                                      
REMARK 465     LYS B    35                                                      
REMARK 465     VAL B    36                                                      
REMARK 465     SER B    37                                                      
REMARK 465     ASP B    38                                                      
REMARK 465     GLY B    39                                                      
REMARK 465     SER B    40                                                      
REMARK 465     SER B    41                                                      
REMARK 465     GLU B    42                                                      
REMARK 465     ILE B    43                                                      
REMARK 465     PHE B    44                                                      
REMARK 465     PHE B    45                                                      
REMARK 465     LYS B    46                                                      
REMARK 465     ILE B    47                                                      
REMARK 465     LYS B    48                                                      
REMARK 465     LYS B    49                                                      
REMARK 465     THR B    50                                                      
REMARK 465     THR B    51                                                      
REMARK 465     PRO B    52                                                      
REMARK 465     LEU B    53                                                      
REMARK 465     ARG B    54                                                      
REMARK 465     ARG B    55                                                      
REMARK 465     LEU B    56                                                      
REMARK 465     MET B    57                                                      
REMARK 465     GLU B    58                                                      
REMARK 465     ALA B    59                                                      
REMARK 465     PHE B    60                                                      
REMARK 465     ALA B    61                                                      
REMARK 465     LYS B    62                                                      
REMARK 465     ARG B    63                                                      
REMARK 465     GLN B    64                                                      
REMARK 465     GLY B    65                                                      
REMARK 465     LYS B    66                                                      
REMARK 465     GLU B    67                                                      
REMARK 465     MET B    68                                                      
REMARK 465     ASP B    69                                                      
REMARK 465     SER B    70                                                      
REMARK 465     LEU B    71                                                      
REMARK 465     ARG B    72                                                      
REMARK 465     PHE B    73                                                      
REMARK 465     LEU B    74                                                      
REMARK 465     TYR B    75                                                      
REMARK 465     ASP B    76                                                      
REMARK 465     GLY B    77                                                      
REMARK 465     ILE B    78                                                      
REMARK 465     ARG B    79                                                      
REMARK 465     ILE B    80                                                      
REMARK 465     GLN B    81                                                      
REMARK 465     ALA B    82                                                      
REMARK 465     ASP B    83                                                      
REMARK 465     GLN B    84                                                      
REMARK 465     THR B    85                                                      
REMARK 465     PRO B    86                                                      
REMARK 465     GLU B    87                                                      
REMARK 465     ASP B    88                                                      
REMARK 465     LEU B    89                                                      
REMARK 465     ASP B    90                                                      
REMARK 465     MET B    91                                                      
REMARK 465     GLU B    92                                                      
REMARK 465     ASP B    93                                                      
REMARK 465     ASN B    94                                                      
REMARK 465     ASP B    95                                                      
REMARK 465     ILE B    96                                                      
REMARK 465     ILE B    97                                                      
REMARK 465     GLU B    98                                                      
REMARK 465     ALA B    99                                                      
REMARK 465     HIS B   100                                                      
REMARK 465     ARG B   101                                                      
REMARK 465     GLU B   102                                                      
REMARK 465     GLN B   103                                                      
REMARK 465     ILE B   104                                                      
REMARK 465     GLY B   105                                                      
REMARK 465     GLY B   106                                                      
REMARK 465     SER B   107                                                      
REMARK 465     ALA B   108                                                      
REMARK 465     GLY B   109                                                      
REMARK 465     GLY B   110                                                      
REMARK 465     PRO B   111                                                      
REMARK 465     GLY B   112                                                      
REMARK 465     SER B   113                                                      
REMARK 465     ARG B   114                                                      
REMARK 465     ALA B   115                                                      
REMARK 465     ARG B   116                                                      
REMARK 465     ALA B   117                                                      
REMARK 465     ALA B   118                                                      
REMARK 465     GLY B   119                                                      
REMARK 465     ALA B   120                                                      
REMARK 465     ARG B   121                                                      
REMARK 465     GLY B   220                                                      
REMARK 465     ASP D    32                                                      
REMARK 465     PRO D    33                                                      
REMARK 465     LEU D    34                                                      
REMARK 465     PRO D    35                                                      
REMARK 465     THR D    36                                                      
REMARK 465     GLU D    37                                                      
REMARK 465     SER D    38                                                      
REMARK 465     ARG D    39                                                      
REMARK 465     LEU D    40                                                      
REMARK 465     MET D    41                                                      
REMARK 465     ASN D    42                                                      
REMARK 465     SER D    43                                                      
REMARK 465     CYS D    44                                                      
REMARK 465     LEU D    45                                                      
REMARK 465     GLN D    46                                                      
REMARK 465     ALA D    47                                                      
REMARK 465     ARG D    48                                                      
REMARK 465     ARG D    49                                                      
REMARK 465     LYS D    50                                                      
REMARK 465     CYS D    51                                                      
REMARK 465     GLN D    52                                                      
REMARK 465     ALA D    53                                                      
REMARK 465     ASP D    54                                                      
REMARK 465     PRO D    55                                                      
REMARK 465     THR D    56                                                      
REMARK 465     CYS D    57                                                      
REMARK 465     SER D    58                                                      
REMARK 465     ALA D    59                                                      
REMARK 465     ALA D    60                                                      
REMARK 465     TYR D    61                                                      
REMARK 465     HIS D    62                                                      
REMARK 465     HIS D    63                                                      
REMARK 465     LEU D    64                                                      
REMARK 465     ASP D    65                                                      
REMARK 465     SER D    66                                                      
REMARK 465     CYS D    67                                                      
REMARK 465     THR D    68                                                      
REMARK 465     SER D    69                                                      
REMARK 465     SER D    70                                                      
REMARK 465     ILE D    71                                                      
REMARK 465     SER D    72                                                      
REMARK 465     THR D    73                                                      
REMARK 465     PRO D    74                                                      
REMARK 465     LEU D    75                                                      
REMARK 465     PRO D    76                                                      
REMARK 465     SER D    77                                                      
REMARK 465     GLU D    78                                                      
REMARK 465     GLU D    79                                                      
REMARK 465     PRO D    80                                                      
REMARK 465     SER D    81                                                      
REMARK 465     VAL D    82                                                      
REMARK 465     PRO D    83                                                      
REMARK 465     ALA D    84                                                      
REMARK 465     ASP D    85                                                      
REMARK 465     CYS D    86                                                      
REMARK 465     LEU D    87                                                      
REMARK 465     GLU D    88                                                      
REMARK 465     ALA D    89                                                      
REMARK 465     ALA D    90                                                      
REMARK 465     GLN D    91                                                      
REMARK 465     GLN D    92                                                      
REMARK 465     LEU D    93                                                      
REMARK 465     ARG D    94                                                      
REMARK 465     ASN D    95                                                      
REMARK 465     SER D    96                                                      
REMARK 465     SER D    97                                                      
REMARK 465     LEU D    98                                                      
REMARK 465     ILE D    99                                                      
REMARK 465     GLY D   100                                                      
REMARK 465     CYS D   101                                                      
REMARK 465     MET D   102                                                      
REMARK 465     CYS D   103                                                      
REMARK 465     HIS D   104                                                      
REMARK 465     ARG D   105                                                      
REMARK 465     ARG D   106                                                      
REMARK 465     MET D   107                                                      
REMARK 465     LYS D   108                                                      
REMARK 465     ASN D   109                                                      
REMARK 465     GLN D   110                                                      
REMARK 465     VAL D   111                                                      
REMARK 465     ALA D   112                                                      
REMARK 465     CYS D   113                                                      
REMARK 465     LEU D   114                                                      
REMARK 465     ASP D   115                                                      
REMARK 465     ILE D   116                                                      
REMARK 465     TYR D   117                                                      
REMARK 465     TRP D   118                                                      
REMARK 465     THR D   119                                                      
REMARK 465     VAL D   120                                                      
REMARK 465     HIS D   121                                                      
REMARK 465     ARG D   122                                                      
REMARK 465     ALA D   123                                                      
REMARK 465     ARG D   124                                                      
REMARK 465     SER D   125                                                      
REMARK 465     LEU D   126                                                      
REMARK 465     GLY D   127                                                      
REMARK 465     ASN D   128                                                      
REMARK 465     TYR D   129                                                      
REMARK 465     GLU D   130                                                      
REMARK 465     LEU D   131                                                      
REMARK 465     ASP D   132                                                      
REMARK 465     VAL D   133                                                      
REMARK 465     SER D   134                                                      
REMARK 465     PRO D   135                                                      
REMARK 465     TYR D   136                                                      
REMARK 465     GLU D   137                                                      
REMARK 465     ASP D   138                                                      
REMARK 465     THR D   139                                                      
REMARK 465     VAL D   140                                                      
REMARK 465     THR D   141                                                      
REMARK 465     SER D   142                                                      
REMARK 465     LYS D   143                                                      
REMARK 465     PRO D   144                                                      
REMARK 465     TRP D   145                                                      
REMARK 465     LYS D   146                                                      
REMARK 465     MET D   147                                                      
REMARK 465     ASN D   148                                                      
REMARK 465     LEU D   149                                                      
REMARK 465     SER D   150                                                      
REMARK 465     LYS D   151                                                      
REMARK 465     LEU D   152                                                      
REMARK 465     ASN D   153                                                      
REMARK 465     MET D   154                                                      
REMARK 465     LEU D   155                                                      
REMARK 465     LYS D   156                                                      
REMARK 465     PRO D   157                                                      
REMARK 465     ASP D   158                                                      
REMARK 465     GLN D   358                                                      
REMARK 465     ASP D   359                                                      
REMARK 465     TRP D   360                                                      
REMARK 465     PRO D   361                                                      
REMARK 465     HIS D   362                                                      
REMARK 465     PRO D   363                                                      
REMARK 465     GLY D   364                                                      
REMARK 465     THR D   365                                                      
REMARK 465     HIS D   366                                                      
REMARK 465     HIS D   367                                                      
REMARK 465     HIS D   368                                                      
REMARK 465     HIS D   369                                                      
REMARK 465     HIS D   370                                                      
REMARK 465     HIS D   371                                                      
REMARK 465     HIS D   372                                                      
REMARK 465     HIS D   373                                                      
REMARK 465     PRO F   129                                                      
REMARK 465     THR F   130                                                      
REMARK 465     SER F   131                                                      
REMARK 465     LEU F   132                                                      
REMARK 465     ARG F   133                                                      
REMARK 465     GLU F   134                                                      
REMARK 465     GLU F   208                                                      
REMARK 465     GLY F   209                                                      
REMARK 465     GLU F   210                                                      
REMARK 465     ALA F   247                                                      
REMARK 465     GLY F   248                                                      
REMARK 465     ALA F   249                                                      
REMARK 465     ARG F   250                                                      
REMARK 465     ASP F   380                                                      
REMARK 465     PHE F   381                                                      
REMARK 465     GLN F   382                                                      
REMARK 465     GLY F   383                                                      
REMARK 465     PRO F   384                                                      
REMARK 465     GLY F   385                                                      
REMARK 465     ALA F   386                                                      
REMARK 465     GLY F   387                                                      
REMARK 465     GLY F   446                                                      
REMARK 465     ALA F   447                                                      
REMARK 465     ASN F   448                                                      
REMARK 465     GLU F   623                                                      
REMARK 465     ASP F   624                                                      
REMARK 465     ILE F   625                                                      
REMARK 465     GLN F   626                                                      
REMARK 465     ASP F   627                                                      
REMARK 465     PRO F   628                                                      
REMARK 465     LEU F   629                                                      
REMARK 465     CYS F   630                                                      
REMARK 465     ASP F   631                                                      
REMARK 465     GLU F   632                                                      
REMARK 465     LEU F   633                                                      
REMARK 465     CYS F   634                                                      
REMARK 465     ARG F   635                                                      
REMARK 465     GLY F   636                                                      
REMARK 465     THR F   637                                                      
REMARK 465     HIS F   638                                                      
REMARK 465     HIS F   639                                                      
REMARK 465     HIS F   640                                                      
REMARK 465     HIS F   641                                                      
REMARK 465     HIS F   642                                                      
REMARK 465     HIS F   643                                                      
REMARK 465     HIS F   644                                                      
REMARK 465     HIS F   645                                                      
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   OD2  ASP F   300     OH   TYR F   314              1.37            
REMARK 500   OD2  ASP E   300     OH   TYR E   314              1.37            
REMARK 500   OD1  ASP E   266     OD2  ASP E   302              1.61            
REMARK 500   OD1  ASP F   266     OD2  ASP F   302              1.61            
REMARK 500   O    THR F   564     OD2  ASP F   567              1.69            
REMARK 500   O    THR E   564     OD2  ASP E   567              1.69            
REMARK 500   OD1  ASP E   230     OE1  GLU E   232              1.82            
REMARK 500   OD1  ASP F   230     OE1  GLU F   232              1.83            
REMARK 500   O    THR F   564     OE2  GLU F   574              1.93            
REMARK 500   O    THR E   564     OE2  GLU E   574              1.93            
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500    ALA E 269   C   -  N   -  CA  ANGL. DEV. =  15.3 DEGREES          
REMARK 500    ALA F 269   C   -  N   -  CA  ANGL. DEV. =  15.3 DEGREES          
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    ASP C 160     -166.23    -76.09                                   
REMARK 500    HIS C 190       30.37    -90.56                                   
REMARK 500    LYS C 206       48.33    -91.85                                   
REMARK 500    ALA C 236       72.47     56.33                                   
REMARK 500    MET C 300       57.80    -95.12                                   
REMARK 500    THR C 310       31.56    -98.39                                   
REMARK 500    CYS C 318       35.58    -97.99                                   
REMARK 500    LEU E  50      -62.49    -94.27                                   
REMARK 500    ARG E  77       47.33     34.36                                   
REMARK 500    CYS E 166      -60.31    -91.42                                   
REMARK 500    PHE E 258       84.99   -152.57                                   
REMARK 500    PHE E 285      -32.60   -130.34                                   
REMARK 500    LYS E 288     -165.63    -79.12                                   
REMARK 500    VAL E 293      -62.20   -102.97                                   
REMARK 500    PRO E 305       83.56    -69.98                                   
REMARK 500    ARG E 313      -60.23   -102.32                                   
REMARK 500    ASN E 343       44.08   -140.69                                   
REMARK 500    LEU E 358     -177.41    -68.18                                   
REMARK 500    ASN E 359      -31.53   -131.34                                   
REMARK 500    ILE E 422      -62.93    -99.25                                   
REMARK 500    CYS E 478       36.24    -99.79                                   
REMARK 500    LYS E 549       35.51    -99.91                                   
REMARK 500    PHE E 555     -165.78   -116.52                                   
REMARK 500    ASP E 584       10.55   -145.76                                   
REMARK 500    CYS E 585       10.18   -141.86                                   
REMARK 500    HIS E 594     -166.80   -128.79                                   
REMARK 500    ASP D 160     -166.18    -76.12                                   
REMARK 500    HIS D 190       30.41    -90.56                                   
REMARK 500    LYS D 206       48.32    -91.85                                   
REMARK 500    ALA D 236       72.51     56.29                                   
REMARK 500    MET D 300       57.85    -95.14                                   
REMARK 500    THR D 310       31.54    -98.38                                   
REMARK 500    CYS D 318       35.60    -98.01                                   
REMARK 500    LEU F  50      -62.54    -94.24                                   
REMARK 500    ARG F  77       47.26     34.45                                   
REMARK 500    CYS F 166      -60.37    -91.40                                   
REMARK 500    PHE F 258       84.98   -152.50                                   
REMARK 500    PHE F 285      -32.55   -130.32                                   
REMARK 500    LYS F 288     -165.63    -79.08                                   
REMARK 500    VAL F 293      -62.22   -102.95                                   
REMARK 500    PRO F 305       83.53    -69.96                                   
REMARK 500    ARG F 313      -60.27   -102.25                                   
REMARK 500    ASN F 343       44.08   -140.75                                   
REMARK 500    LEU F 358     -177.39    -68.20                                   
REMARK 500    ASN F 359      -31.47   -131.35                                   
REMARK 500    ILE F 422      -62.88    -99.27                                   
REMARK 500    CYS F 478       36.20    -99.78                                   
REMARK 500    LYS F 549       35.54    -99.93                                   
REMARK 500    PHE F 555     -165.80   -116.51                                   
REMARK 500    ASP F 584       10.53   -145.76                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS      52 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 620                                                                      
REMARK 620 METAL COORDINATION                                                   
REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE):                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              CA E 709  CA                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 GLU E 178   OE1                                                    
REMARK 620 2 GLU E 178   OE2  58.7                                              
REMARK 620 3 ASP E 230   OD1  82.4 140.8                                        
REMARK 620 4 GLU E 232   OE1  98.3 138.1  45.7                                  
REMARK 620 5 GLU E 232   OE2 107.7 100.1  96.2  50.5                            
REMARK 620 6 ASP E 267   OD1 145.8  97.4 119.8  83.8  48.6                      
REMARK 620 7 ASP E 267   OD2 160.7 139.2  78.8  71.8  79.3  51.6                
REMARK 620 N                    1     2     3     4     5     6                 
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              CA E 708  CA                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 GLU E 232   OE2                                                    
REMARK 620 2 ASP E 264   OD1 102.3                                              
REMARK 620 3 GLU E 265   O   127.0  68.7                                        
REMARK 620 4 ASP E 267   OD1  57.1 126.6  85.8                                  
REMARK 620 5 ASP E 302   OD1 124.8 132.4  85.8  88.7                            
REMARK 620 N                    1     2     3     4                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              CA E 707  CA                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 ASP E 266   OD1                                                    
REMARK 620 2 SER E 268   O    87.8                                              
REMARK 620 3 ASP E 300   OD1 116.5  79.8                                        
REMARK 620 4 ASP E 300   OD2 126.0 128.2  51.4                                  
REMARK 620 5 ASP E 302   OD2  38.2  70.6  79.6 110.3                            
REMARK 620 6 TYR E 314   OH  131.7 140.5  81.5  33.5 138.6                      
REMARK 620 7 ASP E 378   OD1 104.0 118.1 136.7  92.8 142.2  59.3                
REMARK 620 8 ASP E 378   OD2 132.6  76.3 104.3  97.7 145.5  75.1  51.1          
REMARK 620 N                    1     2     3     4     5     6     7           
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              CA E 710  CA                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 THR E 564   O                                                      
REMARK 620 2 CYS E 565   O   114.8                                              
REMARK 620 3 ASP E 567   OD1  89.1  76.6                                        
REMARK 620 4 ASP E 567   OD2  40.1 114.1  53.0                                  
REMARK 620 5 HIS E 569   O   106.7 122.8  66.2  75.7                            
REMARK 620 6 GLU E 574   OE1  96.5 145.7 119.5  98.8  54.5                      
REMARK 620 7 GLU E 574   OE2  52.8 133.8 136.8  84.0 102.4  56.4                
REMARK 620 N                    1     2     3     4     5     6                 
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              CA F 709  CA                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 GLU F 178   OE1                                                    
REMARK 620 2 GLU F 178   OE2  58.7                                              
REMARK 620 3 ASP F 230   OD1  82.4 140.8                                        
REMARK 620 4 GLU F 232   OE1  98.3 138.1  45.7                                  
REMARK 620 5 GLU F 232   OE2 107.7 100.1  96.2  50.5                            
REMARK 620 6 ASP F 267   OD1 145.8  97.4 119.8  83.8  48.6                      
REMARK 620 7 ASP F 267   OD2 160.6 139.2  78.8  71.8  79.3  51.6                
REMARK 620 N                    1     2     3     4     5     6                 
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              CA F 708  CA                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 GLU F 232   OE2                                                    
REMARK 620 2 ASP F 264   OD1 102.3                                              
REMARK 620 3 GLU F 265   O   127.0  68.7                                        
REMARK 620 4 ASP F 267   OD1  57.1 126.6  85.8                                  
REMARK 620 5 ASP F 302   OD1 124.8 132.4  85.8  88.7                            
REMARK 620 N                    1     2     3     4                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              CA F 707  CA                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 ASP F 266   OD1                                                    
REMARK 620 2 SER F 268   O    87.8                                              
REMARK 620 3 ASP F 300   OD1 116.5  79.9                                        
REMARK 620 4 ASP F 300   OD2 126.0 128.2  51.4                                  
REMARK 620 5 ASP F 302   OD2  38.2  70.6  79.6 110.3                            
REMARK 620 6 TYR F 314   OH  131.7 140.5  81.5  33.5 138.6                      
REMARK 620 7 ASP F 378   OD1 104.0 118.2 136.7  92.7 142.2  59.3                
REMARK 620 8 ASP F 378   OD2 132.6  76.3 104.4  97.7 145.5  75.1  51.1          
REMARK 620 N                    1     2     3     4     5     6     7           
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              CA F 710  CA                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 THR F 564   O                                                      
REMARK 620 2 CYS F 565   O   114.8                                              
REMARK 620 3 ASP F 567   OD1  89.1  76.6                                        
REMARK 620 4 ASP F 567   OD2  40.1 114.1  53.0                                  
REMARK 620 5 HIS F 569   O   106.7 122.8  66.2  75.8                            
REMARK 620 6 GLU F 574   OE1  96.5 145.6 119.6  98.8  54.5                      
REMARK 620 7 GLU F 574   OE2  52.8 133.8 136.8  84.0 102.4  56.4                
REMARK 620 N                    1     2     3     4     5     6                 
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: EMD-20579   RELATED DB: EMDB                             
REMARK 900 CRYO-EM STRUCTURE OF RET/GFRA3/ARTN EXTRACELLULAR COMPLEX. THE 3D    
REMARK 900 REFINEMENT WAS APPLIED WITH C2 SYMMETRY.                             
DBREF  6Q2S A    9   106  UNP    Q12306   SMT3_YEAST       1     98             
DBREF  6Q2S A  108   220  UNP    Q5T4W7   ARTN_HUMAN     108    220             
DBREF  6Q2S C   32   363  UNP    O60609   GFRA3_HUMAN     32    363             
DBREF  6Q2S E   29   635  UNP    P07949   RET_HUMAN       29    635             
DBREF  6Q2S B    9   106  UNP    Q12306   SMT3_YEAST       1     98             
DBREF  6Q2S B  108   220  UNP    Q5T4W7   ARTN_HUMAN     108    220             
DBREF  6Q2S D   32   363  UNP    O60609   GFRA3_HUMAN     32    363             
DBREF  6Q2S F   29   635  UNP    P07949   RET_HUMAN       29    635             
SEQADV 6Q2S MET A  -14  UNP  Q12306              INITIATING METHIONINE          
SEQADV 6Q2S GLY A  -13  UNP  Q12306              EXPRESSION TAG                 
SEQADV 6Q2S SER A  -12  UNP  Q12306              EXPRESSION TAG                 
SEQADV 6Q2S SER A  -11  UNP  Q12306              EXPRESSION TAG                 
SEQADV 6Q2S HIS A  -10  UNP  Q12306              EXPRESSION TAG                 
SEQADV 6Q2S HIS A   -9  UNP  Q12306              EXPRESSION TAG                 
SEQADV 6Q2S HIS A   -8  UNP  Q12306              EXPRESSION TAG                 
SEQADV 6Q2S HIS A   -7  UNP  Q12306              EXPRESSION TAG                 
SEQADV 6Q2S HIS A   -6  UNP  Q12306              EXPRESSION TAG                 
SEQADV 6Q2S HIS A   -5  UNP  Q12306              EXPRESSION TAG                 
SEQADV 6Q2S SER A   -4  UNP  Q12306              EXPRESSION TAG                 
SEQADV 6Q2S SER A   -3  UNP  Q12306              EXPRESSION TAG                 
SEQADV 6Q2S GLY A   -2  UNP  Q12306              EXPRESSION TAG                 
SEQADV 6Q2S LEU A   -1  UNP  Q12306              EXPRESSION TAG                 
SEQADV 6Q2S VAL A    0  UNP  Q12306              EXPRESSION TAG                 
SEQADV 6Q2S PRO A    1  UNP  Q12306              EXPRESSION TAG                 
SEQADV 6Q2S ARG A    2  UNP  Q12306              EXPRESSION TAG                 
SEQADV 6Q2S GLY A    3  UNP  Q12306              EXPRESSION TAG                 
SEQADV 6Q2S SER A    4  UNP  Q12306              EXPRESSION TAG                 
SEQADV 6Q2S HIS A    5  UNP  Q12306              EXPRESSION TAG                 
SEQADV 6Q2S MET A    6  UNP  Q12306              EXPRESSION TAG                 
SEQADV 6Q2S ALA A    7  UNP  Q12306              EXPRESSION TAG                 
SEQADV 6Q2S SER A    8  UNP  Q12306              EXPRESSION TAG                 
SEQADV 6Q2S SER A  107  UNP  Q12306              LINKER                         
SEQADV 6Q2S GLY C  364  UNP  O60609              EXPRESSION TAG                 
SEQADV 6Q2S THR C  365  UNP  O60609              EXPRESSION TAG                 
SEQADV 6Q2S HIS C  366  UNP  O60609              EXPRESSION TAG                 
SEQADV 6Q2S HIS C  367  UNP  O60609              EXPRESSION TAG                 
SEQADV 6Q2S HIS C  368  UNP  O60609              EXPRESSION TAG                 
SEQADV 6Q2S HIS C  369  UNP  O60609              EXPRESSION TAG                 
SEQADV 6Q2S HIS C  370  UNP  O60609              EXPRESSION TAG                 
SEQADV 6Q2S HIS C  371  UNP  O60609              EXPRESSION TAG                 
SEQADV 6Q2S HIS C  372  UNP  O60609              EXPRESSION TAG                 
SEQADV 6Q2S HIS C  373  UNP  O60609              EXPRESSION TAG                 
SEQADV 6Q2S HIS E  114  UNP  P07949    ARG   114 CONFLICT                       
SEQADV 6Q2S GLY E  636  UNP  P07949              EXPRESSION TAG                 
SEQADV 6Q2S THR E  637  UNP  P07949              EXPRESSION TAG                 
SEQADV 6Q2S HIS E  638  UNP  P07949              EXPRESSION TAG                 
SEQADV 6Q2S HIS E  639  UNP  P07949              EXPRESSION TAG                 
SEQADV 6Q2S HIS E  640  UNP  P07949              EXPRESSION TAG                 
SEQADV 6Q2S HIS E  641  UNP  P07949              EXPRESSION TAG                 
SEQADV 6Q2S HIS E  642  UNP  P07949              EXPRESSION TAG                 
SEQADV 6Q2S HIS E  643  UNP  P07949              EXPRESSION TAG                 
SEQADV 6Q2S HIS E  644  UNP  P07949              EXPRESSION TAG                 
SEQADV 6Q2S HIS E  645  UNP  P07949              EXPRESSION TAG                 
SEQADV 6Q2S MET B  -14  UNP  Q12306              INITIATING METHIONINE          
SEQADV 6Q2S GLY B  -13  UNP  Q12306              EXPRESSION TAG                 
SEQADV 6Q2S SER B  -12  UNP  Q12306              EXPRESSION TAG                 
SEQADV 6Q2S SER B  -11  UNP  Q12306              EXPRESSION TAG                 
SEQADV 6Q2S HIS B  -10  UNP  Q12306              EXPRESSION TAG                 
SEQADV 6Q2S HIS B   -9  UNP  Q12306              EXPRESSION TAG                 
SEQADV 6Q2S HIS B   -8  UNP  Q12306              EXPRESSION TAG                 
SEQADV 6Q2S HIS B   -7  UNP  Q12306              EXPRESSION TAG                 
SEQADV 6Q2S HIS B   -6  UNP  Q12306              EXPRESSION TAG                 
SEQADV 6Q2S HIS B   -5  UNP  Q12306              EXPRESSION TAG                 
SEQADV 6Q2S SER B   -4  UNP  Q12306              EXPRESSION TAG                 
SEQADV 6Q2S SER B   -3  UNP  Q12306              EXPRESSION TAG                 
SEQADV 6Q2S GLY B   -2  UNP  Q12306              EXPRESSION TAG                 
SEQADV 6Q2S LEU B   -1  UNP  Q12306              EXPRESSION TAG                 
SEQADV 6Q2S VAL B    0  UNP  Q12306              EXPRESSION TAG                 
SEQADV 6Q2S PRO B    1  UNP  Q12306              EXPRESSION TAG                 
SEQADV 6Q2S ARG B    2  UNP  Q12306              EXPRESSION TAG                 
SEQADV 6Q2S GLY B    3  UNP  Q12306              EXPRESSION TAG                 
SEQADV 6Q2S SER B    4  UNP  Q12306              EXPRESSION TAG                 
SEQADV 6Q2S HIS B    5  UNP  Q12306              EXPRESSION TAG                 
SEQADV 6Q2S MET B    6  UNP  Q12306              EXPRESSION TAG                 
SEQADV 6Q2S ALA B    7  UNP  Q12306              EXPRESSION TAG                 
SEQADV 6Q2S SER B    8  UNP  Q12306              EXPRESSION TAG                 
SEQADV 6Q2S SER B  107  UNP  Q12306              LINKER                         
SEQADV 6Q2S GLY D  364  UNP  O60609              EXPRESSION TAG                 
SEQADV 6Q2S THR D  365  UNP  O60609              EXPRESSION TAG                 
SEQADV 6Q2S HIS D  366  UNP  O60609              EXPRESSION TAG                 
SEQADV 6Q2S HIS D  367  UNP  O60609              EXPRESSION TAG                 
SEQADV 6Q2S HIS D  368  UNP  O60609              EXPRESSION TAG                 
SEQADV 6Q2S HIS D  369  UNP  O60609              EXPRESSION TAG                 
SEQADV 6Q2S HIS D  370  UNP  O60609              EXPRESSION TAG                 
SEQADV 6Q2S HIS D  371  UNP  O60609              EXPRESSION TAG                 
SEQADV 6Q2S HIS D  372  UNP  O60609              EXPRESSION TAG                 
SEQADV 6Q2S HIS D  373  UNP  O60609              EXPRESSION TAG                 
SEQADV 6Q2S HIS F  114  UNP  P07949    ARG   114 CONFLICT                       
SEQADV 6Q2S GLY F  636  UNP  P07949              EXPRESSION TAG                 
SEQADV 6Q2S THR F  637  UNP  P07949              EXPRESSION TAG                 
SEQADV 6Q2S HIS F  638  UNP  P07949              EXPRESSION TAG                 
SEQADV 6Q2S HIS F  639  UNP  P07949              EXPRESSION TAG                 
SEQADV 6Q2S HIS F  640  UNP  P07949              EXPRESSION TAG                 
SEQADV 6Q2S HIS F  641  UNP  P07949              EXPRESSION TAG                 
SEQADV 6Q2S HIS F  642  UNP  P07949              EXPRESSION TAG                 
SEQADV 6Q2S HIS F  643  UNP  P07949              EXPRESSION TAG                 
SEQADV 6Q2S HIS F  644  UNP  P07949              EXPRESSION TAG                 
SEQADV 6Q2S HIS F  645  UNP  P07949              EXPRESSION TAG                 
SEQRES   1 A  235  MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY          
SEQRES   2 A  235  LEU VAL PRO ARG GLY SER HIS MET ALA SER MET SER ASP          
SEQRES   3 A  235  SER GLU VAL ASN GLN GLU ALA LYS PRO GLU VAL LYS PRO          
SEQRES   4 A  235  GLU VAL LYS PRO GLU THR HIS ILE ASN LEU LYS VAL SER          
SEQRES   5 A  235  ASP GLY SER SER GLU ILE PHE PHE LYS ILE LYS LYS THR          
SEQRES   6 A  235  THR PRO LEU ARG ARG LEU MET GLU ALA PHE ALA LYS ARG          
SEQRES   7 A  235  GLN GLY LYS GLU MET ASP SER LEU ARG PHE LEU TYR ASP          
SEQRES   8 A  235  GLY ILE ARG ILE GLN ALA ASP GLN THR PRO GLU ASP LEU          
SEQRES   9 A  235  ASP MET GLU ASP ASN ASP ILE ILE GLU ALA HIS ARG GLU          
SEQRES  10 A  235  GLN ILE GLY GLY SER ALA GLY GLY PRO GLY SER ARG ALA          
SEQRES  11 A  235  ARG ALA ALA GLY ALA ARG GLY CYS ARG LEU ARG SER GLN          
SEQRES  12 A  235  LEU VAL PRO VAL ARG ALA LEU GLY LEU GLY HIS ARG SER          
SEQRES  13 A  235  ASP GLU LEU VAL ARG PHE ARG PHE CYS SER GLY SER CYS          
SEQRES  14 A  235  ARG ARG ALA ARG SER PRO HIS ASP LEU SER LEU ALA SER          
SEQRES  15 A  235  LEU LEU GLY ALA GLY ALA LEU ARG PRO PRO PRO GLY SER          
SEQRES  16 A  235  ARG PRO VAL SER GLN PRO CYS CYS ARG PRO THR ARG TYR          
SEQRES  17 A  235  GLU ALA VAL SER PHE MET ASP VAL ASN SER THR TRP ARG          
SEQRES  18 A  235  THR VAL ASP ARG LEU SER ALA THR ALA CYS GLY CYS LEU          
SEQRES  19 A  235  GLY                                                          
SEQRES   1 C  342  ASP PRO LEU PRO THR GLU SER ARG LEU MET ASN SER CYS          
SEQRES   2 C  342  LEU GLN ALA ARG ARG LYS CYS GLN ALA ASP PRO THR CYS          
SEQRES   3 C  342  SER ALA ALA TYR HIS HIS LEU ASP SER CYS THR SER SER          
SEQRES   4 C  342  ILE SER THR PRO LEU PRO SER GLU GLU PRO SER VAL PRO          
SEQRES   5 C  342  ALA ASP CYS LEU GLU ALA ALA GLN GLN LEU ARG ASN SER          
SEQRES   6 C  342  SER LEU ILE GLY CYS MET CYS HIS ARG ARG MET LYS ASN          
SEQRES   7 C  342  GLN VAL ALA CYS LEU ASP ILE TYR TRP THR VAL HIS ARG          
SEQRES   8 C  342  ALA ARG SER LEU GLY ASN TYR GLU LEU ASP VAL SER PRO          
SEQRES   9 C  342  TYR GLU ASP THR VAL THR SER LYS PRO TRP LYS MET ASN          
SEQRES  10 C  342  LEU SER LYS LEU ASN MET LEU LYS PRO ASP SER ASP LEU          
SEQRES  11 C  342  CYS LEU LYS PHE ALA MET LEU CYS THR LEU ASN ASP LYS          
SEQRES  12 C  342  CYS ASP ARG LEU ARG LYS ALA TYR GLY GLU ALA CYS SER          
SEQRES  13 C  342  GLY PRO HIS CYS GLN ARG HIS VAL CYS LEU ARG GLN LEU          
SEQRES  14 C  342  LEU THR PHE PHE GLU LYS ALA ALA GLU PRO HIS ALA GLN          
SEQRES  15 C  342  GLY LEU LEU LEU CYS PRO CYS ALA PRO ASN ASP ARG GLY          
SEQRES  16 C  342  CYS GLY GLU ARG ARG ARG ASN THR ILE ALA PRO ASN CYS          
SEQRES  17 C  342  ALA LEU PRO PRO VAL ALA PRO ASN CYS LEU GLU LEU ARG          
SEQRES  18 C  342  ARG LEU CYS PHE SER ASP PRO LEU CYS ARG SER ARG LEU          
SEQRES  19 C  342  VAL ASP PHE GLN THR HIS CYS HIS PRO MET ASP ILE LEU          
SEQRES  20 C  342  GLY THR CYS ALA THR GLU GLN SER ARG CYS LEU ARG ALA          
SEQRES  21 C  342  TYR LEU GLY LEU ILE GLY THR ALA MET THR PRO ASN PHE          
SEQRES  22 C  342  VAL SER ASN VAL ASN THR SER VAL ALA LEU SER CYS THR          
SEQRES  23 C  342  CYS ARG GLY SER GLY ASN LEU GLN GLU GLU CYS GLU MET          
SEQRES  24 C  342  LEU GLU GLY PHE PHE SER HIS ASN PRO CYS LEU THR GLU          
SEQRES  25 C  342  ALA ILE ALA ALA LYS MET ARG PHE HIS SER GLN LEU PHE          
SEQRES  26 C  342  SER GLN ASP TRP PRO HIS PRO GLY THR HIS HIS HIS HIS          
SEQRES  27 C  342  HIS HIS HIS HIS                                              
SEQRES   1 E  617  LEU TYR PHE SER ARG ASP ALA TYR TRP GLU LYS LEU TYR          
SEQRES   2 E  617  VAL ASP GLN ALA ALA GLY THR PRO LEU LEU TYR VAL HIS          
SEQRES   3 E  617  ALA LEU ARG ASP ALA PRO GLU GLU VAL PRO SER PHE ARG          
SEQRES   4 E  617  LEU GLY GLN HIS LEU TYR GLY THR TYR ARG THR ARG LEU          
SEQRES   5 E  617  HIS GLU ASN ASN TRP ILE CYS ILE GLN GLU ASP THR GLY          
SEQRES   6 E  617  LEU LEU TYR LEU ASN ARG SER LEU ASP HIS SER SER TRP          
SEQRES   7 E  617  GLU LYS LEU SER VAL ARG ASN HIS GLY PHE PRO LEU LEU          
SEQRES   8 E  617  THR VAL TYR LEU LYS VAL PHE LEU SER PRO THR SER LEU          
SEQRES   9 E  617  ARG GLU GLY GLU CYS GLN TRP PRO GLY CYS ALA ARG VAL          
SEQRES  10 E  617  TYR PHE SER PHE PHE ASN THR SER PHE PRO ALA CYS SER          
SEQRES  11 E  617  SER LEU LYS PRO ARG GLU LEU CYS PHE PRO GLU THR ARG          
SEQRES  12 E  617  PRO SER PHE ARG ILE ARG GLU ASN ARG PRO PRO GLY THR          
SEQRES  13 E  617  PHE HIS GLN PHE ARG LEU LEU PRO VAL GLN PHE LEU CYS          
SEQRES  14 E  617  PRO ASN ILE SER VAL ALA TYR ARG LEU LEU GLU GLY GLU          
SEQRES  15 E  617  GLY LEU PRO PHE ARG CYS ALA PRO ASP SER LEU GLU VAL          
SEQRES  16 E  617  SER THR ARG TRP ALA LEU ASP ARG GLU GLN ARG GLU LYS          
SEQRES  17 E  617  TYR GLU LEU VAL ALA VAL CYS THR VAL HIS ALA GLY ALA          
SEQRES  18 E  617  ARG GLU GLU VAL VAL MET VAL PRO PHE PRO VAL THR VAL          
SEQRES  19 E  617  TYR ASP GLU ASP ASP SER ALA PRO THR PHE PRO ALA GLY          
SEQRES  20 E  617  VAL ASP THR ALA SER ALA VAL VAL GLU PHE LYS ARG LYS          
SEQRES  21 E  617  GLU ASP THR VAL VAL ALA THR LEU ARG VAL PHE ASP ALA          
SEQRES  22 E  617  ASP VAL VAL PRO ALA SER GLY GLU LEU VAL ARG ARG TYR          
SEQRES  23 E  617  THR SER THR LEU LEU PRO GLY ASP THR TRP ALA GLN GLN          
SEQRES  24 E  617  THR PHE ARG VAL GLU HIS TRP PRO ASN GLU THR SER VAL          
SEQRES  25 E  617  GLN ALA ASN GLY SER PHE VAL ARG ALA THR VAL HIS ASP          
SEQRES  26 E  617  TYR ARG LEU VAL LEU ASN ARG ASN LEU SER ILE SER GLU          
SEQRES  27 E  617  ASN ARG THR MET GLN LEU ALA VAL LEU VAL ASN ASP SER          
SEQRES  28 E  617  ASP PHE GLN GLY PRO GLY ALA GLY VAL LEU LEU LEU HIS          
SEQRES  29 E  617  PHE ASN VAL SER VAL LEU PRO VAL SER LEU HIS LEU PRO          
SEQRES  30 E  617  SER THR TYR SER LEU SER VAL SER ARG ARG ALA ARG ARG          
SEQRES  31 E  617  PHE ALA GLN ILE GLY LYS VAL CYS VAL GLU ASN CYS GLN          
SEQRES  32 E  617  ALA PHE SER GLY ILE ASN VAL GLN TYR LYS LEU HIS SER          
SEQRES  33 E  617  SER GLY ALA ASN CYS SER THR LEU GLY VAL VAL THR SER          
SEQRES  34 E  617  ALA GLU ASP THR SER GLY ILE LEU PHE VAL ASN ASP THR          
SEQRES  35 E  617  LYS ALA LEU ARG ARG PRO LYS CYS ALA GLU LEU HIS TYR          
SEQRES  36 E  617  MET VAL VAL ALA THR ASP GLN GLN THR SER ARG GLN ALA          
SEQRES  37 E  617  GLN ALA GLN LEU LEU VAL THR VAL GLU GLY SER TYR VAL          
SEQRES  38 E  617  ALA GLU GLU ALA GLY CYS PRO LEU SER CYS ALA VAL SER          
SEQRES  39 E  617  LYS ARG ARG LEU GLU CYS GLU GLU CYS GLY GLY LEU GLY          
SEQRES  40 E  617  SER PRO THR GLY ARG CYS GLU TRP ARG GLN GLY ASP GLY          
SEQRES  41 E  617  LYS GLY ILE THR ARG ASN PHE SER THR CYS SER PRO SER          
SEQRES  42 E  617  THR LYS THR CYS PRO ASP GLY HIS CYS ASP VAL VAL GLU          
SEQRES  43 E  617  THR GLN ASP ILE ASN ILE CYS PRO GLN ASP CYS LEU ARG          
SEQRES  44 E  617  GLY SER ILE VAL GLY GLY HIS GLU PRO GLY GLU PRO ARG          
SEQRES  45 E  617  GLY ILE LYS ALA GLY TYR GLY THR CYS ASN CYS PHE PRO          
SEQRES  46 E  617  GLU GLU GLU LYS CYS PHE CYS GLU PRO GLU ASP ILE GLN          
SEQRES  47 E  617  ASP PRO LEU CYS ASP GLU LEU CYS ARG GLY THR HIS HIS          
SEQRES  48 E  617  HIS HIS HIS HIS HIS HIS                                      
SEQRES   1 B  235  MET GLY SER SER HIS HIS HIS HIS HIS HIS SER SER GLY          
SEQRES   2 B  235  LEU VAL PRO ARG GLY SER HIS MET ALA SER MET SER ASP          
SEQRES   3 B  235  SER GLU VAL ASN GLN GLU ALA LYS PRO GLU VAL LYS PRO          
SEQRES   4 B  235  GLU VAL LYS PRO GLU THR HIS ILE ASN LEU LYS VAL SER          
SEQRES   5 B  235  ASP GLY SER SER GLU ILE PHE PHE LYS ILE LYS LYS THR          
SEQRES   6 B  235  THR PRO LEU ARG ARG LEU MET GLU ALA PHE ALA LYS ARG          
SEQRES   7 B  235  GLN GLY LYS GLU MET ASP SER LEU ARG PHE LEU TYR ASP          
SEQRES   8 B  235  GLY ILE ARG ILE GLN ALA ASP GLN THR PRO GLU ASP LEU          
SEQRES   9 B  235  ASP MET GLU ASP ASN ASP ILE ILE GLU ALA HIS ARG GLU          
SEQRES  10 B  235  GLN ILE GLY GLY SER ALA GLY GLY PRO GLY SER ARG ALA          
SEQRES  11 B  235  ARG ALA ALA GLY ALA ARG GLY CYS ARG LEU ARG SER GLN          
SEQRES  12 B  235  LEU VAL PRO VAL ARG ALA LEU GLY LEU GLY HIS ARG SER          
SEQRES  13 B  235  ASP GLU LEU VAL ARG PHE ARG PHE CYS SER GLY SER CYS          
SEQRES  14 B  235  ARG ARG ALA ARG SER PRO HIS ASP LEU SER LEU ALA SER          
SEQRES  15 B  235  LEU LEU GLY ALA GLY ALA LEU ARG PRO PRO PRO GLY SER          
SEQRES  16 B  235  ARG PRO VAL SER GLN PRO CYS CYS ARG PRO THR ARG TYR          
SEQRES  17 B  235  GLU ALA VAL SER PHE MET ASP VAL ASN SER THR TRP ARG          
SEQRES  18 B  235  THR VAL ASP ARG LEU SER ALA THR ALA CYS GLY CYS LEU          
SEQRES  19 B  235  GLY                                                          
SEQRES   1 D  342  ASP PRO LEU PRO THR GLU SER ARG LEU MET ASN SER CYS          
SEQRES   2 D  342  LEU GLN ALA ARG ARG LYS CYS GLN ALA ASP PRO THR CYS          
SEQRES   3 D  342  SER ALA ALA TYR HIS HIS LEU ASP SER CYS THR SER SER          
SEQRES   4 D  342  ILE SER THR PRO LEU PRO SER GLU GLU PRO SER VAL PRO          
SEQRES   5 D  342  ALA ASP CYS LEU GLU ALA ALA GLN GLN LEU ARG ASN SER          
SEQRES   6 D  342  SER LEU ILE GLY CYS MET CYS HIS ARG ARG MET LYS ASN          
SEQRES   7 D  342  GLN VAL ALA CYS LEU ASP ILE TYR TRP THR VAL HIS ARG          
SEQRES   8 D  342  ALA ARG SER LEU GLY ASN TYR GLU LEU ASP VAL SER PRO          
SEQRES   9 D  342  TYR GLU ASP THR VAL THR SER LYS PRO TRP LYS MET ASN          
SEQRES  10 D  342  LEU SER LYS LEU ASN MET LEU LYS PRO ASP SER ASP LEU          
SEQRES  11 D  342  CYS LEU LYS PHE ALA MET LEU CYS THR LEU ASN ASP LYS          
SEQRES  12 D  342  CYS ASP ARG LEU ARG LYS ALA TYR GLY GLU ALA CYS SER          
SEQRES  13 D  342  GLY PRO HIS CYS GLN ARG HIS VAL CYS LEU ARG GLN LEU          
SEQRES  14 D  342  LEU THR PHE PHE GLU LYS ALA ALA GLU PRO HIS ALA GLN          
SEQRES  15 D  342  GLY LEU LEU LEU CYS PRO CYS ALA PRO ASN ASP ARG GLY          
SEQRES  16 D  342  CYS GLY GLU ARG ARG ARG ASN THR ILE ALA PRO ASN CYS          
SEQRES  17 D  342  ALA LEU PRO PRO VAL ALA PRO ASN CYS LEU GLU LEU ARG          
SEQRES  18 D  342  ARG LEU CYS PHE SER ASP PRO LEU CYS ARG SER ARG LEU          
SEQRES  19 D  342  VAL ASP PHE GLN THR HIS CYS HIS PRO MET ASP ILE LEU          
SEQRES  20 D  342  GLY THR CYS ALA THR GLU GLN SER ARG CYS LEU ARG ALA          
SEQRES  21 D  342  TYR LEU GLY LEU ILE GLY THR ALA MET THR PRO ASN PHE          
SEQRES  22 D  342  VAL SER ASN VAL ASN THR SER VAL ALA LEU SER CYS THR          
SEQRES  23 D  342  CYS ARG GLY SER GLY ASN LEU GLN GLU GLU CYS GLU MET          
SEQRES  24 D  342  LEU GLU GLY PHE PHE SER HIS ASN PRO CYS LEU THR GLU          
SEQRES  25 D  342  ALA ILE ALA ALA LYS MET ARG PHE HIS SER GLN LEU PHE          
SEQRES  26 D  342  SER GLN ASP TRP PRO HIS PRO GLY THR HIS HIS HIS HIS          
SEQRES  27 D  342  HIS HIS HIS HIS                                              
SEQRES   1 F  617  LEU TYR PHE SER ARG ASP ALA TYR TRP GLU LYS LEU TYR          
SEQRES   2 F  617  VAL ASP GLN ALA ALA GLY THR PRO LEU LEU TYR VAL HIS          
SEQRES   3 F  617  ALA LEU ARG ASP ALA PRO GLU GLU VAL PRO SER PHE ARG          
SEQRES   4 F  617  LEU GLY GLN HIS LEU TYR GLY THR TYR ARG THR ARG LEU          
SEQRES   5 F  617  HIS GLU ASN ASN TRP ILE CYS ILE GLN GLU ASP THR GLY          
SEQRES   6 F  617  LEU LEU TYR LEU ASN ARG SER LEU ASP HIS SER SER TRP          
SEQRES   7 F  617  GLU LYS LEU SER VAL ARG ASN HIS GLY PHE PRO LEU LEU          
SEQRES   8 F  617  THR VAL TYR LEU LYS VAL PHE LEU SER PRO THR SER LEU          
SEQRES   9 F  617  ARG GLU GLY GLU CYS GLN TRP PRO GLY CYS ALA ARG VAL          
SEQRES  10 F  617  TYR PHE SER PHE PHE ASN THR SER PHE PRO ALA CYS SER          
SEQRES  11 F  617  SER LEU LYS PRO ARG GLU LEU CYS PHE PRO GLU THR ARG          
SEQRES  12 F  617  PRO SER PHE ARG ILE ARG GLU ASN ARG PRO PRO GLY THR          
SEQRES  13 F  617  PHE HIS GLN PHE ARG LEU LEU PRO VAL GLN PHE LEU CYS          
SEQRES  14 F  617  PRO ASN ILE SER VAL ALA TYR ARG LEU LEU GLU GLY GLU          
SEQRES  15 F  617  GLY LEU PRO PHE ARG CYS ALA PRO ASP SER LEU GLU VAL          
SEQRES  16 F  617  SER THR ARG TRP ALA LEU ASP ARG GLU GLN ARG GLU LYS          
SEQRES  17 F  617  TYR GLU LEU VAL ALA VAL CYS THR VAL HIS ALA GLY ALA          
SEQRES  18 F  617  ARG GLU GLU VAL VAL MET VAL PRO PHE PRO VAL THR VAL          
SEQRES  19 F  617  TYR ASP GLU ASP ASP SER ALA PRO THR PHE PRO ALA GLY          
SEQRES  20 F  617  VAL ASP THR ALA SER ALA VAL VAL GLU PHE LYS ARG LYS          
SEQRES  21 F  617  GLU ASP THR VAL VAL ALA THR LEU ARG VAL PHE ASP ALA          
SEQRES  22 F  617  ASP VAL VAL PRO ALA SER GLY GLU LEU VAL ARG ARG TYR          
SEQRES  23 F  617  THR SER THR LEU LEU PRO GLY ASP THR TRP ALA GLN GLN          
SEQRES  24 F  617  THR PHE ARG VAL GLU HIS TRP PRO ASN GLU THR SER VAL          
SEQRES  25 F  617  GLN ALA ASN GLY SER PHE VAL ARG ALA THR VAL HIS ASP          
SEQRES  26 F  617  TYR ARG LEU VAL LEU ASN ARG ASN LEU SER ILE SER GLU          
SEQRES  27 F  617  ASN ARG THR MET GLN LEU ALA VAL LEU VAL ASN ASP SER          
SEQRES  28 F  617  ASP PHE GLN GLY PRO GLY ALA GLY VAL LEU LEU LEU HIS          
SEQRES  29 F  617  PHE ASN VAL SER VAL LEU PRO VAL SER LEU HIS LEU PRO          
SEQRES  30 F  617  SER THR TYR SER LEU SER VAL SER ARG ARG ALA ARG ARG          
SEQRES  31 F  617  PHE ALA GLN ILE GLY LYS VAL CYS VAL GLU ASN CYS GLN          
SEQRES  32 F  617  ALA PHE SER GLY ILE ASN VAL GLN TYR LYS LEU HIS SER          
SEQRES  33 F  617  SER GLY ALA ASN CYS SER THR LEU GLY VAL VAL THR SER          
SEQRES  34 F  617  ALA GLU ASP THR SER GLY ILE LEU PHE VAL ASN ASP THR          
SEQRES  35 F  617  LYS ALA LEU ARG ARG PRO LYS CYS ALA GLU LEU HIS TYR          
SEQRES  36 F  617  MET VAL VAL ALA THR ASP GLN GLN THR SER ARG GLN ALA          
SEQRES  37 F  617  GLN ALA GLN LEU LEU VAL THR VAL GLU GLY SER TYR VAL          
SEQRES  38 F  617  ALA GLU GLU ALA GLY CYS PRO LEU SER CYS ALA VAL SER          
SEQRES  39 F  617  LYS ARG ARG LEU GLU CYS GLU GLU CYS GLY GLY LEU GLY          
SEQRES  40 F  617  SER PRO THR GLY ARG CYS GLU TRP ARG GLN GLY ASP GLY          
SEQRES  41 F  617  LYS GLY ILE THR ARG ASN PHE SER THR CYS SER PRO SER          
SEQRES  42 F  617  THR LYS THR CYS PRO ASP GLY HIS CYS ASP VAL VAL GLU          
SEQRES  43 F  617  THR GLN ASP ILE ASN ILE CYS PRO GLN ASP CYS LEU ARG          
SEQRES  44 F  617  GLY SER ILE VAL GLY GLY HIS GLU PRO GLY GLU PRO ARG          
SEQRES  45 F  617  GLY ILE LYS ALA GLY TYR GLY THR CYS ASN CYS PHE PRO          
SEQRES  46 F  617  GLU GLU GLU LYS CYS PHE CYS GLU PRO GLU ASP ILE GLN          
SEQRES  47 F  617  ASP PRO LEU CYS ASP GLU LEU CYS ARG GLY THR HIS HIS          
SEQRES  48 F  617  HIS HIS HIS HIS HIS HIS                                      
HET    NAG  C1100      14                                                       
HET    NAG  E 701      14                                                       
HET    NAG  E 702      14                                                       
HET    NAG  E 703      14                                                       
HET    NAG  E 704      14                                                       
HET    NAG  E 705      14                                                       
HET    NAG  E 706      14                                                       
HET     CA  E 707       1                                                       
HET     CA  E 708       1                                                       
HET     CA  E 709       1                                                       
HET     CA  E 710       1                                                       
HET    NAG  D1100      14                                                       
HET    NAG  F 701      14                                                       
HET    NAG  F 702      14                                                       
HET    NAG  F 703      14                                                       
HET    NAG  F 704      14                                                       
HET    NAG  F 705      14                                                       
HET    NAG  F 706      14                                                       
HET     CA  F 707       1                                                       
HET     CA  F 708       1                                                       
HET     CA  F 709       1                                                       
HET     CA  F 710       1                                                       
HETNAM     NAG 2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSE                         
HETNAM      CA CALCIUM ION                                                      
FORMUL   7  NAG    14(C8 H15 N O6)                                              
FORMUL  14   CA    8(CA 2+)                                                     
HELIX    1 AA1 ARG A  133  GLY A  136  5                                   4    
HELIX    2 AA2 SER A  159  LEU A  169  1                                  11    
HELIX    3 AA3 ASP C  160  LEU C  171  1                                  12    
HELIX    4 AA4 ASN C  172  GLU C  184  1                                  13    
HELIX    5 AA5 GLN C  192  LEU C  197  1                                   6    
HELIX    6 AA6 LEU C  197  LYS C  206  1                                  10    
HELIX    7 AA7 ALA C  208  LEU C  217  1                                  10    
HELIX    8 AA8 ASP C  224  ASN C  233  1                                  10    
HELIX    9 AA9 ALA C  236  LEU C  241  1                                   6    
HELIX   10 AB1 LEU C  249  ASP C  258  1                                  10    
HELIX   11 AB2 LEU C  260  CYS C  272  1                                  13    
HELIX   12 AB3 SER C  286  LEU C  293  1                                   8    
HELIX   13 AB4 GLY C  294  ILE C  296  5                                   3    
HELIX   14 AB5 GLN C  325  HIS C  337  1                                  13    
HELIX   15 AB6 ASN C  338  PHE C  356  1                                  19    
HELIX   16 AB7 SER E  104  LEU E  109  1                                   6    
HELIX   17 AB8 ALA E  156  LEU E  160  5                                   5    
HELIX   18 AB9 PRO E  162  PHE E  167  1                                   6    
HELIX   19 AC1 LEU E  190  CYS E  197  1                                   8    
HELIX   20 AC2 GLU E  309  TYR E  314  1                                   6    
HELIX   21 AC3 ASP E  322  PHE E  329  1                                   8    
HELIX   22 AC4 SER E  518  SER E  522  5                                   5    
HELIX   23 AC5 ARG E  525  GLU E  530  1                                   6    
HELIX   24 AC6 CYS E  581  CYS E  585  5                                   5    
HELIX   25 AC7 ARG B  133  GLY B  136  5                                   4    
HELIX   26 AC8 SER B  159  LEU B  169  1                                  11    
HELIX   27 AC9 ASP D  160  LEU D  171  1                                  12    
HELIX   28 AD1 ASN D  172  GLU D  184  1                                  13    
HELIX   29 AD2 GLN D  192  LEU D  197  1                                   6    
HELIX   30 AD3 LEU D  197  LYS D  206  1                                  10    
HELIX   31 AD4 ALA D  208  LEU D  217  1                                  10    
HELIX   32 AD5 ASP D  224  ASN D  233  1                                  10    
HELIX   33 AD6 ALA D  236  LEU D  241  1                                   6    
HELIX   34 AD7 LEU D  249  ASP D  258  1                                  10    
HELIX   35 AD8 LEU D  260  CYS D  272  1                                  13    
HELIX   36 AD9 SER D  286  LEU D  293  1                                   8    
HELIX   37 AE1 GLY D  294  ILE D  296  5                                   3    
HELIX   38 AE2 GLN D  325  HIS D  337  1                                  13    
HELIX   39 AE3 ASN D  338  PHE D  356  1                                  19    
HELIX   40 AE4 SER F  104  LEU F  109  1                                   6    
HELIX   41 AE5 ALA F  156  LEU F  160  5                                   5    
HELIX   42 AE6 PRO F  162  PHE F  167  1                                   6    
HELIX   43 AE7 LEU F  190  CYS F  197  1                                   8    
HELIX   44 AE8 GLU F  309  TYR F  314  1                                   6    
HELIX   45 AE9 ASP F  322  PHE F  329  1                                   8    
HELIX   46 AF1 SER F  518  SER F  522  5                                   5    
HELIX   47 AF2 ARG F  525  GLU F  530  1                                   6    
HELIX   48 AF3 CYS F  581  CYS F  585  5                                   5    
SHEET    1 AA1 2 ARG A 124  LEU A 125  0                                        
SHEET    2 AA1 2 CYS A 150  SER A 151 -1  O  SER A 151   N  ARG A 124           
SHEET    1 AA2 2 GLN A 128  PRO A 131  0                                        
SHEET    2 AA2 2 LEU A 144  PHE A 147 -1  O  VAL A 145   N  VAL A 130           
SHEET    1 AA3 2 CYS A 187  MET A 199  0                                        
SHEET    2 AA3 2 TRP A 205  LEU A 219 -1  O  SER A 212   N  GLU A 194           
SHEET    1 AA4 2 ASN C 303  PHE C 304  0                                        
SHEET    2 AA4 2 VAL C 312  ALA C 313 -1  O  ALA C 313   N  ASN C 303           
SHEET    1 AA5 2 TYR E  30  PHE E  31  0                                        
SHEET    2 AA5 2 ALA E  55  LEU E  56 -1  O  LEU E  56   N  TYR E  30           
SHEET    1 AA6 3 ALA E  35  TYR E  36  0                                        
SHEET    2 AA6 3 CYS E 142  SER E 153  1  O  TYR E 146   N  TYR E  36           
SHEET    3 AA6 3 LYS E  39  VAL E  42  1  N  VAL E  42   O  THR E 152           
SHEET    1 AA7 3 ALA E  35  TYR E  36  0                                        
SHEET    2 AA7 3 CYS E 142  SER E 153  1  O  TYR E 146   N  TYR E  36           
SHEET    3 AA7 3 VAL E 121  PHE E 126 -1  N  VAL E 121   O  PHE E 147           
SHEET    1 AA8 3 THR E  48  TYR E  52  0                                        
SHEET    2 AA8 3 LEU E  94  LEU E  97 -1  O  LEU E  95   N  LEU E  50           
SHEET    3 AA8 3 ILE E  86  GLN E  89 -1  N  CYS E  87   O  TYR E  96           
SHEET    1 AA9 4 PHE E 174  ILE E 176  0                                        
SHEET    2 AA9 4 GLU E 252  VAL E 262  1  O  PRO E 259   N  PHE E 174           
SHEET    3 AA9 4 LYS E 236  VAL E 245 -1  N  TYR E 237   O  VAL E 260           
SHEET    4 AA9 4 VAL E 202  LEU E 206 -1  N  ALA E 203   O  THR E 244           
SHEET    1 AB1 3 THR E 184  GLN E 187  0                                        
SHEET    2 AB1 3 GLU E 222  THR E 225 -1  O  VAL E 223   N  HIS E 186           
SHEET    3 AB1 3 PHE E 214  CYS E 216 -1  N  ARG E 215   O  SER E 224           
SHEET    1 AB2 3 VAL E 292  ASP E 300  0                                        
SHEET    2 AB2 3 PHE E 346  VAL E 357 -1  O  LEU E 356   N  ALA E 294           
SHEET    3 AB2 3 ARG E 330  GLN E 341 -1  N  THR E 338   O  ALA E 349           
SHEET    1 AB3 3 SER E 316  LEU E 318  0                                        
SHEET    2 AB3 3 ARG E 368  VAL E 376 -1  O  LEU E 375   N  THR E 317           
SHEET    3 AB3 3 LEU E 389  VAL E 397 -1  O  LEU E 391   N  VAL E 374           
SHEET    1 AB4 4 THR E 407  SER E 413  0                                        
SHEET    2 AB4 4 ALA E 496  GLU E 505  1  O  GLU E 505   N  VAL E 412           
SHEET    3 AB4 4 TYR E 483  ASP E 489 -1  N  VAL E 485   O  ALA E 498           
SHEET    4 AB4 4 VAL E 438  SER E 444 -1  N  LYS E 441   O  VAL E 486           
SHEET    1 AB5 3 THR E 407  SER E 413  0                                        
SHEET    2 AB5 3 ALA E 496  GLU E 505  1  O  GLU E 505   N  VAL E 412           
SHEET    3 AB5 3 GLU E 480  LEU E 481 -1  N  LEU E 481   O  VAL E 502           
SHEET    1 AB6 3 GLN E 421  VAL E 425  0                                        
SHEET    2 AB6 3 SER E 462  VAL E 467 -1  O  GLY E 463   N  VAL E 425           
SHEET    3 AB6 3 LEU E 452  SER E 457 -1  N  GLY E 453   O  PHE E 466           
SHEET    1 AB7 2 GLU E 542  ARG E 544  0                                        
SHEET    2 AB7 2 THR E 557  SER E 559 -1  O  SER E 559   N  GLU E 542           
SHEET    1 AB8 3 ILE E 551  THR E 552  0                                        
SHEET    2 AB8 3 ILE E 602  TYR E 606 -1  O  GLY E 605   N  THR E 552           
SHEET    3 AB8 3 HIS E 594  PRO E 596 -1  N  GLU E 595   O  ALA E 604           
SHEET    1 AB9 3 SER E 589  VAL E 591  0                                        
SHEET    2 AB9 3 LYS E 617  GLU E 621  1  O  CYS E 620   N  VAL E 591           
SHEET    3 AB9 3 THR E 608  PHE E 612 -1  N  THR E 608   O  GLU E 621           
SHEET    1 AC1 2 ARG B 124  LEU B 125  0                                        
SHEET    2 AC1 2 CYS B 150  SER B 151 -1  O  SER B 151   N  ARG B 124           
SHEET    1 AC2 2 GLN B 128  PRO B 131  0                                        
SHEET    2 AC2 2 LEU B 144  PHE B 147 -1  O  VAL B 145   N  VAL B 130           
SHEET    1 AC3 2 CYS B 187  MET B 199  0                                        
SHEET    2 AC3 2 TRP B 205  LEU B 219 -1  O  SER B 212   N  GLU B 194           
SHEET    1 AC4 2 ASN D 303  PHE D 304  0                                        
SHEET    2 AC4 2 VAL D 312  ALA D 313 -1  O  ALA D 313   N  ASN D 303           
SHEET    1 AC5 2 TYR F  30  PHE F  31  0                                        
SHEET    2 AC5 2 ALA F  55  LEU F  56 -1  O  LEU F  56   N  TYR F  30           
SHEET    1 AC6 3 ALA F  35  TYR F  36  0                                        
SHEET    2 AC6 3 CYS F 142  SER F 153  1  O  TYR F 146   N  TYR F  36           
SHEET    3 AC6 3 LYS F  39  VAL F  42  1  N  VAL F  42   O  THR F 152           
SHEET    1 AC7 3 ALA F  35  TYR F  36  0                                        
SHEET    2 AC7 3 CYS F 142  SER F 153  1  O  TYR F 146   N  TYR F  36           
SHEET    3 AC7 3 VAL F 121  PHE F 126 -1  N  VAL F 121   O  PHE F 147           
SHEET    1 AC8 3 THR F  48  TYR F  52  0                                        
SHEET    2 AC8 3 LEU F  94  LEU F  97 -1  O  LEU F  95   N  LEU F  50           
SHEET    3 AC8 3 ILE F  86  GLN F  89 -1  N  CYS F  87   O  TYR F  96           
SHEET    1 AC9 4 PHE F 174  ILE F 176  0                                        
SHEET    2 AC9 4 GLU F 252  VAL F 262  1  O  PRO F 259   N  PHE F 174           
SHEET    3 AC9 4 LYS F 236  VAL F 245 -1  N  TYR F 237   O  VAL F 260           
SHEET    4 AC9 4 VAL F 202  LEU F 206 -1  N  ALA F 203   O  THR F 244           
SHEET    1 AD1 3 THR F 184  GLN F 187  0                                        
SHEET    2 AD1 3 GLU F 222  THR F 225 -1  O  VAL F 223   N  HIS F 186           
SHEET    3 AD1 3 PHE F 214  CYS F 216 -1  N  ARG F 215   O  SER F 224           
SHEET    1 AD2 3 VAL F 292  ASP F 300  0                                        
SHEET    2 AD2 3 PHE F 346  VAL F 357 -1  O  LEU F 356   N  ALA F 294           
SHEET    3 AD2 3 ARG F 330  GLN F 341 -1  N  THR F 338   O  ALA F 349           
SHEET    1 AD3 3 SER F 316  LEU F 318  0                                        
SHEET    2 AD3 3 ARG F 368  VAL F 376 -1  O  LEU F 375   N  THR F 317           
SHEET    3 AD3 3 LEU F 389  VAL F 397 -1  O  LEU F 391   N  VAL F 374           
SHEET    1 AD4 4 THR F 407  SER F 413  0                                        
SHEET    2 AD4 4 ALA F 496  GLU F 505  1  O  GLU F 505   N  VAL F 412           
SHEET    3 AD4 4 TYR F 483  ASP F 489 -1  N  VAL F 485   O  ALA F 498           
SHEET    4 AD4 4 VAL F 438  SER F 444 -1  N  LYS F 441   O  VAL F 486           
SHEET    1 AD5 3 THR F 407  SER F 413  0                                        
SHEET    2 AD5 3 ALA F 496  GLU F 505  1  O  GLU F 505   N  VAL F 412           
SHEET    3 AD5 3 GLU F 480  LEU F 481 -1  N  LEU F 481   O  VAL F 502           
SHEET    1 AD6 3 GLN F 421  VAL F 425  0                                        
SHEET    2 AD6 3 SER F 462  VAL F 467 -1  O  GLY F 463   N  VAL F 425           
SHEET    3 AD6 3 LEU F 452  SER F 457 -1  N  GLY F 453   O  PHE F 466           
SHEET    1 AD7 2 GLU F 542  ARG F 544  0                                        
SHEET    2 AD7 2 THR F 557  SER F 559 -1  O  SER F 559   N  GLU F 542           
SHEET    1 AD8 3 ILE F 551  THR F 552  0                                        
SHEET    2 AD8 3 ILE F 602  TYR F 606 -1  O  GLY F 605   N  THR F 552           
SHEET    3 AD8 3 HIS F 594  PRO F 596 -1  N  GLU F 595   O  ALA F 604           
SHEET    1 AD9 3 SER F 589  VAL F 591  0                                        
SHEET    2 AD9 3 LYS F 617  GLU F 621  1  O  CYS F 620   N  VAL F 591           
SHEET    3 AD9 3 THR F 608  PHE F 612 -1  N  THR F 608   O  GLU F 621           
SSBOND   1 CYS A  123    CYS A  188                          1555   1555  2.03  
SSBOND   2 CYS A  150    CYS A  216                          1555   1555  2.02  
SSBOND   3 CYS A  154    CYS A  218                          1555   1555  2.02  
SSBOND   4 CYS A  187    CYS B  187                          1555   1555  2.05  
SSBOND   5 CYS C  162    CYS C  218                          1555   1555  2.02  
SSBOND   6 CYS C  169    CYS C  175                          1555   1555  2.02  
SSBOND   7 CYS C  186    CYS C  196                          1555   1555  2.02  
SSBOND   8 CYS C  191    CYS C  239                          1555   1555  2.03  
SSBOND   9 CYS C  248    CYS C  316                          1555   1555  2.04  
SSBOND  10 CYS C  255    CYS C  261                          1555   1555  2.03  
SSBOND  11 CYS C  272    CYS C  288                          1555   1555  2.03  
SSBOND  12 CYS C  281    CYS C  340                          1555   1555  2.03  
SSBOND  13 CYS C  318    CYS C  328                          1555   1555  2.03  
SSBOND  14 CYS E  137    CYS E  142                          1555   1555  2.03  
SSBOND  15 CYS E  157    CYS E  197                          1555   1555  2.03  
SSBOND  16 CYS E  166    CYS E  243                          1555   1555  2.03  
SSBOND  17 CYS E  426    CYS E  430                          1555   1555  2.02  
SSBOND  18 CYS E  449    CYS E  478                          1555   1555  2.03  
SSBOND  19 CYS E  515    CYS E  531                          1555   1555  2.03  
SSBOND  20 CYS E  519    CYS E  541                          1555   1555  2.03  
SSBOND  21 CYS E  528    CYS E  558                          1555   1555  2.02  
SSBOND  22 CYS E  565    CYS E  581                          1555   1555  2.02  
SSBOND  23 CYS E  570    CYS E  585                          1555   1555  2.03  
SSBOND  24 CYS E  609    CYS E  620                          1555   1555  2.04  
SSBOND  25 CYS E  611    CYS E  618                          1555   1555  2.03  
SSBOND  26 CYS B  123    CYS B  188                          1555   1555  2.04  
SSBOND  27 CYS B  150    CYS B  216                          1555   1555  2.02  
SSBOND  28 CYS B  154    CYS B  218                          1555   1555  2.02  
SSBOND  29 CYS D  162    CYS D  218                          1555   1555  2.02  
SSBOND  30 CYS D  169    CYS D  175                          1555   1555  2.02  
SSBOND  31 CYS D  186    CYS D  196                          1555   1555  2.02  
SSBOND  32 CYS D  191    CYS D  239                          1555   1555  2.03  
SSBOND  33 CYS D  248    CYS D  316                          1555   1555  2.04  
SSBOND  34 CYS D  255    CYS D  261                          1555   1555  2.03  
SSBOND  35 CYS D  272    CYS D  288                          1555   1555  2.03  
SSBOND  36 CYS D  281    CYS D  340                          1555   1555  2.03  
SSBOND  37 CYS D  318    CYS D  328                          1555   1555  2.03  
SSBOND  38 CYS F  137    CYS F  142                          1555   1555  2.03  
SSBOND  39 CYS F  157    CYS F  197                          1555   1555  2.03  
SSBOND  40 CYS F  166    CYS F  243                          1555   1555  2.03  
SSBOND  41 CYS F  426    CYS F  430                          1555   1555  2.02  
SSBOND  42 CYS F  449    CYS F  478                          1555   1555  2.03  
SSBOND  43 CYS F  515    CYS F  531                          1555   1555  2.03  
SSBOND  44 CYS F  519    CYS F  541                          1555   1555  2.03  
SSBOND  45 CYS F  528    CYS F  558                          1555   1555  2.02  
SSBOND  46 CYS F  565    CYS F  581                          1555   1555  2.02  
SSBOND  47 CYS F  570    CYS F  585                          1555   1555  2.03  
SSBOND  48 CYS F  609    CYS F  620                          1555   1555  2.04  
SSBOND  49 CYS F  611    CYS F  618                          1555   1555  2.03  
LINK         ND2 ASN C 309                 C1  NAG C1100     1555   1555  1.43  
LINK         ND2 ASN E  98                 C1  NAG E 705     1555   1555  1.45  
LINK         ND2 ASN E 336                 C1  NAG E 701     1555   1555  1.43  
LINK         ND2 ASN E 361                 C1  NAG E 706     1555   1555  1.48  
LINK         ND2 ASN E 377                 C1  NAG E 702     1555   1555  1.46  
LINK         ND2 ASN E 394                 C1  NAG E 703     1555   1555  1.44  
LINK         ND2 ASN E 468                 C1  NAG E 704     1555   1555  1.45  
LINK         ND2 ASN D 309                 C1  NAG D1100     1555   1555  1.43  
LINK         ND2 ASN F  98                 C1  NAG F 705     1555   1555  1.45  
LINK         ND2 ASN F 336                 C1  NAG F 701     1555   1555  1.43  
LINK         ND2 ASN F 361                 C1  NAG F 706     1555   1555  1.48  
LINK         ND2 ASN F 377                 C1  NAG F 702     1555   1555  1.46  
LINK         ND2 ASN F 394                 C1  NAG F 703     1555   1555  1.44  
LINK         ND2 ASN F 468                 C1  NAG F 704     1555   1555  1.45  
LINK         OE1 GLU E 178                CA    CA E 709     1555   1555  2.22  
LINK         OE2 GLU E 178                CA    CA E 709     1555   1555  2.28  
LINK         OD1 ASP E 230                CA    CA E 709     1555   1555  2.35  
LINK         OE2 GLU E 232                CA    CA E 708     1555   1555  2.20  
LINK         OE1 GLU E 232                CA    CA E 709     1555   1555  2.35  
LINK         OE2 GLU E 232                CA    CA E 709     1555   1555  2.71  
LINK         OD1 ASP E 264                CA    CA E 708     1555   1555  2.46  
LINK         O   GLU E 265                CA    CA E 708     1555   1555  2.24  
LINK         OD1 ASP E 266                CA    CA E 707     1555   1555  2.56  
LINK         OD1 ASP E 267                CA    CA E 708     1555   1555  2.48  
LINK         OD1 ASP E 267                CA    CA E 709     1555   1555  2.77  
LINK         OD2 ASP E 267                CA    CA E 709     1555   1555  2.09  
LINK         O   SER E 268                CA    CA E 707     1555   1555  2.69  
LINK         OD1 ASP E 300                CA    CA E 707     1555   1555  2.68  
LINK         OD2 ASP E 300                CA    CA E 707     1555   1555  2.23  
LINK         OD2 ASP E 302                CA    CA E 707     1555   1555  2.31  
LINK         OD1 ASP E 302                CA    CA E 708     1555   1555  2.53  
LINK         OH  TYR E 314                CA    CA E 707     1555   1555  2.45  
LINK         OD1 ASP E 378                CA    CA E 707     1555   1555  2.64  
LINK         OD2 ASP E 378                CA    CA E 707     1555   1555  2.36  
LINK         O   THR E 564                CA    CA E 710     1555   1555  2.14  
LINK         O   CYS E 565                CA    CA E 710     1555   1555  2.01  
LINK         OD1 ASP E 567                CA    CA E 710     1555   1555  2.19  
LINK         OD2 ASP E 567                CA    CA E 710     1555   1555  2.62  
LINK         O   HIS E 569                CA    CA E 710     1555   1555  2.95  
LINK         OE1 GLU E 574                CA    CA E 710     1555   1555  2.41  
LINK         OE2 GLU E 574                CA    CA E 710     1555   1555  2.20  
LINK         OE1 GLU F 178                CA    CA F 709     1555   1555  2.22  
LINK         OE2 GLU F 178                CA    CA F 709     1555   1555  2.28  
LINK         OD1 ASP F 230                CA    CA F 709     1555   1555  2.35  
LINK         OE2 GLU F 232                CA    CA F 708     1555   1555  2.20  
LINK         OE1 GLU F 232                CA    CA F 709     1555   1555  2.35  
LINK         OE2 GLU F 232                CA    CA F 709     1555   1555  2.71  
LINK         OD1 ASP F 264                CA    CA F 708     1555   1555  2.46  
LINK         O   GLU F 265                CA    CA F 708     1555   1555  2.24  
LINK         OD1 ASP F 266                CA    CA F 707     1555   1555  2.56  
LINK         OD1 ASP F 267                CA    CA F 708     1555   1555  2.48  
LINK         OD1 ASP F 267                CA    CA F 709     1555   1555  2.77  
LINK         OD2 ASP F 267                CA    CA F 709     1555   1555  2.09  
LINK         O   SER F 268                CA    CA F 707     1555   1555  2.69  
LINK         OD1 ASP F 300                CA    CA F 707     1555   1555  2.68  
LINK         OD2 ASP F 300                CA    CA F 707     1555   1555  2.23  
LINK         OD2 ASP F 302                CA    CA F 707     1555   1555  2.31  
LINK         OD1 ASP F 302                CA    CA F 708     1555   1555  2.53  
LINK         OH  TYR F 314                CA    CA F 707     1555   1555  2.45  
LINK         OD1 ASP F 378                CA    CA F 707     1555   1555  2.64  
LINK         OD2 ASP F 378                CA    CA F 707     1555   1555  2.36  
LINK         O   THR F 564                CA    CA F 710     1555   1555  2.14  
LINK         O   CYS F 565                CA    CA F 710     1555   1555  2.01  
LINK         OD1 ASP F 567                CA    CA F 710     1555   1555  2.19  
LINK         OD2 ASP F 567                CA    CA F 710     1555   1555  2.62  
LINK         O   HIS F 569                CA    CA F 710     1555   1555  2.95  
LINK         OE1 GLU F 574                CA    CA F 710     1555   1555  2.41  
LINK         OE2 GLU F 574                CA    CA F 710     1555   1555  2.20  
CISPEP   1 TRP E  139    PRO E  140          0        -3.32                     
CISPEP   2 TRP F  139    PRO F  140          0        -3.30                     
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1                      
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      1.000000  0.000000  0.000000        0.00000                         
SCALE2      0.000000  1.000000  0.000000        0.00000                         
SCALE3      0.000000  0.000000  1.000000        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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