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Database: PDB
Entry: 6Q6H
LinkDB: 6Q6H
Original site: 6Q6H 
HEADER    CELL CYCLE                              11-DEC-18   6Q6H              
TITLE     CRYO-EM STRUCTURE OF THE APC/C-CDC20-CDK2-CYCLINA2-CKS2 COMPLEX, THE  
TITLE    2 D2 BOX CLASS                                                         
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT 10;                     
COMPND   3 CHAIN: L;                                                            
COMPND   4 SYNONYM: APC10,CYCLOSOME SUBUNIT 10;                                 
COMPND   5 ENGINEERED: YES;                                                     
COMPND   6 MOL_ID: 2;                                                           
COMPND   7 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT 15;                     
COMPND   8 CHAIN: D;                                                            
COMPND   9 SYNONYM: APC15;                                                      
COMPND  10 ENGINEERED: YES;                                                     
COMPND  11 MOL_ID: 3;                                                           
COMPND  12 MOLECULE: APC1;                                                      
COMPND  13 CHAIN: A;                                                            
COMPND  14 ENGINEERED: YES;                                                     
COMPND  15 MUTATION: YES;                                                       
COMPND  16 MOL_ID: 4;                                                           
COMPND  17 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT 2;                      
COMPND  18 CHAIN: N;                                                            
COMPND  19 SYNONYM: APC2,CYCLOSOME SUBUNIT 2;                                   
COMPND  20 ENGINEERED: YES;                                                     
COMPND  21 MOL_ID: 5;                                                           
COMPND  22 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT 4;                      
COMPND  23 CHAIN: I;                                                            
COMPND  24 SYNONYM: APC4,CYCLOSOME SUBUNIT 4;                                   
COMPND  25 ENGINEERED: YES;                                                     
COMPND  26 MOL_ID: 6;                                                           
COMPND  27 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT 5;                      
COMPND  28 CHAIN: O;                                                            
COMPND  29 SYNONYM: APC5,CYCLOSOME SUBUNIT 5;                                   
COMPND  30 ENGINEERED: YES;                                                     
COMPND  31 MOL_ID: 7;                                                           
COMPND  32 MOLECULE: CELL DIVISION CYCLE PROTEIN 16 HOMOLOG;                    
COMPND  33 CHAIN: K, Q;                                                         
COMPND  34 SYNONYM: ANAPHASE-PROMOTING COMPLEX SUBUNIT 6,APC6,CDC16 HOMOLOG,    
COMPND  35 CDC16HS,CYCLOSOME SUBUNIT 6;                                         
COMPND  36 ENGINEERED: YES;                                                     
COMPND  37 MOL_ID: 8;                                                           
COMPND  38 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT 11;                     
COMPND  39 CHAIN: C;                                                            
COMPND  40 SYNONYM: APC11,CYCLOSOME SUBUNIT 11,HEPATOCELLULAR CARCINOMA-        
COMPND  41 ASSOCIATED RING FINGER PROTEIN;                                      
COMPND  42 ENGINEERED: YES;                                                     
COMPND  43 MOL_ID: 9;                                                           
COMPND  44 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT CDC26;                  
COMPND  45 CHAIN: G, W;                                                         
COMPND  46 SYNONYM: ANAPHASE-PROMOTING COMPLEX SUBUNIT 12,APC12,CELL DIVISION   
COMPND  47 CYCLE PROTEIN 26 HOMOLOG;                                            
COMPND  48 ENGINEERED: YES;                                                     
COMPND  49 MOL_ID: 10;                                                          
COMPND  50 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT 13;                     
COMPND  51 CHAIN: M;                                                            
COMPND  52 SYNONYM: APC13,CYCLOSOME SUBUNIT 13;                                 
COMPND  53 ENGINEERED: YES;                                                     
COMPND  54 MOL_ID: 11;                                                          
COMPND  55 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT 16;                     
COMPND  56 CHAIN: H;                                                            
COMPND  57 SYNONYM: APC16,CYCLOSOME SUBUNIT 16;                                 
COMPND  58 ENGINEERED: YES;                                                     
COMPND  59 MOL_ID: 12;                                                          
COMPND  60 MOLECULE: CELL DIVISION CYCLE PROTEIN 27 HOMOLOG;                    
COMPND  61 CHAIN: J, P;                                                         
COMPND  62 SYNONYM: ANAPHASE-PROMOTING COMPLEX SUBUNIT 3,APC3,CDC27 HOMOLOG,    
COMPND  63 CDC27HS,H-NUC;                                                       
COMPND  64 ENGINEERED: YES;                                                     
COMPND  65 MOL_ID: 13;                                                          
COMPND  66 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT 7;                      
COMPND  67 CHAIN: Y, Z;                                                         
COMPND  68 SYNONYM: APC7,CYCLOSOME SUBUNIT 7;                                   
COMPND  69 ENGINEERED: YES;                                                     
COMPND  70 MOL_ID: 14;                                                          
COMPND  71 MOLECULE: CELL DIVISION CYCLE PROTEIN 23 HOMOLOG;                    
COMPND  72 CHAIN: U, V;                                                         
COMPND  73 SYNONYM: ANAPHASE-PROMOTING COMPLEX SUBUNIT 8,APC8,CYCLOSOME SUBUNIT 
COMPND  74 8;                                                                   
COMPND  75 ENGINEERED: YES;                                                     
COMPND  76 MOL_ID: 15;                                                          
COMPND  77 MOLECULE: CELL DIVISION CYCLE PROTEIN 20 HOMOLOG;                    
COMPND  78 CHAIN: R;                                                            
COMPND  79 SYNONYM: P55CDC;                                                     
COMPND  80 ENGINEERED: YES;                                                     
COMPND  81 MOL_ID: 16;                                                          
COMPND  82 MOLECULE: CYCLIN-A2;                                                 
COMPND  83 CHAIN: S;                                                            
COMPND  84 SYNONYM: CYCLIN-A,CYCLIN A;                                          
COMPND  85 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   3 ORGANISM_COMMON: HUMAN;                                              
SOURCE   4 ORGANISM_TAXID: 9606;                                                
SOURCE   5 GENE: ANAPC10, APC10;                                                
SOURCE   6 EXPRESSION_SYSTEM: UNIDENTIFIED BACULOVIRUS;                         
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 10469;                                      
SOURCE   8 MOL_ID: 2;                                                           
SOURCE   9 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  10 ORGANISM_COMMON: HUMAN;                                              
SOURCE  11 ORGANISM_TAXID: 9606;                                                
SOURCE  12 GENE: ANAPC15, C11ORF51, HSPC020;                                    
SOURCE  13 EXPRESSION_SYSTEM: UNIDENTIFIED BACULOVIRUS;                         
SOURCE  14 EXPRESSION_SYSTEM_TAXID: 10469;                                      
SOURCE  15 MOL_ID: 3;                                                           
SOURCE  16 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  17 ORGANISM_COMMON: HUMAN;                                              
SOURCE  18 ORGANISM_TAXID: 9606;                                                
SOURCE  19 EXPRESSION_SYSTEM: UNIDENTIFIED BACULOVIRUS;                         
SOURCE  20 EXPRESSION_SYSTEM_TAXID: 10469;                                      
SOURCE  21 MOL_ID: 4;                                                           
SOURCE  22 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  23 ORGANISM_COMMON: HUMAN;                                              
SOURCE  24 ORGANISM_TAXID: 9606;                                                
SOURCE  25 GENE: ANAPC2, APC2, KIAA1406;                                        
SOURCE  26 EXPRESSION_SYSTEM: UNIDENTIFIED BACULOVIRUS;                         
SOURCE  27 EXPRESSION_SYSTEM_TAXID: 10469;                                      
SOURCE  28 MOL_ID: 5;                                                           
SOURCE  29 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  30 ORGANISM_COMMON: HUMAN;                                              
SOURCE  31 ORGANISM_TAXID: 9606;                                                
SOURCE  32 GENE: ANAPC4, APC4;                                                  
SOURCE  33 EXPRESSION_SYSTEM: UNIDENTIFIED BACULOVIRUS;                         
SOURCE  34 EXPRESSION_SYSTEM_TAXID: 10469;                                      
SOURCE  35 MOL_ID: 6;                                                           
SOURCE  36 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  37 ORGANISM_COMMON: HUMAN;                                              
SOURCE  38 ORGANISM_TAXID: 9606;                                                
SOURCE  39 GENE: ANAPC5, APC5;                                                  
SOURCE  40 EXPRESSION_SYSTEM: UNIDENTIFIED BACULOVIRUS;                         
SOURCE  41 EXPRESSION_SYSTEM_TAXID: 10469;                                      
SOURCE  42 MOL_ID: 7;                                                           
SOURCE  43 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  44 ORGANISM_COMMON: HUMAN;                                              
SOURCE  45 ORGANISM_TAXID: 9606;                                                
SOURCE  46 GENE: CDC16, ANAPC6;                                                 
SOURCE  47 EXPRESSION_SYSTEM: UNIDENTIFIED BACULOVIRUS;                         
SOURCE  48 EXPRESSION_SYSTEM_TAXID: 10469;                                      
SOURCE  49 MOL_ID: 8;                                                           
SOURCE  50 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  51 ORGANISM_COMMON: HUMAN;                                              
SOURCE  52 ORGANISM_TAXID: 9606;                                                
SOURCE  53 GENE: ANAPC11, HSPC214;                                              
SOURCE  54 EXPRESSION_SYSTEM: UNIDENTIFIED BACULOVIRUS;                         
SOURCE  55 EXPRESSION_SYSTEM_TAXID: 10469;                                      
SOURCE  56 MOL_ID: 9;                                                           
SOURCE  57 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  58 ORGANISM_COMMON: HUMAN;                                              
SOURCE  59 ORGANISM_TAXID: 9606;                                                
SOURCE  60 GENE: CDC26, ANAPC12, C9ORF17;                                       
SOURCE  61 EXPRESSION_SYSTEM: UNIDENTIFIED BACULOVIRUS;                         
SOURCE  62 EXPRESSION_SYSTEM_TAXID: 10469;                                      
SOURCE  63 MOL_ID: 10;                                                          
SOURCE  64 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  65 ORGANISM_COMMON: HUMAN;                                              
SOURCE  66 ORGANISM_TAXID: 9606;                                                
SOURCE  67 GENE: ANAPC13;                                                       
SOURCE  68 EXPRESSION_SYSTEM: UNIDENTIFIED BACULOVIRUS;                         
SOURCE  69 EXPRESSION_SYSTEM_TAXID: 10469;                                      
SOURCE  70 MOL_ID: 11;                                                          
SOURCE  71 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  72 ORGANISM_COMMON: HUMAN;                                              
SOURCE  73 ORGANISM_TAXID: 9606;                                                
SOURCE  74 GENE: ANAPC16, C10ORF104, CENP-27;                                   
SOURCE  75 EXPRESSION_SYSTEM: UNIDENTIFIED BACULOVIRUS;                         
SOURCE  76 EXPRESSION_SYSTEM_TAXID: 10469;                                      
SOURCE  77 MOL_ID: 12;                                                          
SOURCE  78 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  79 ORGANISM_COMMON: HUMAN;                                              
SOURCE  80 ORGANISM_TAXID: 9606;                                                
SOURCE  81 GENE: CDC27, ANAPC3, D0S1430E, D17S978E;                             
SOURCE  82 EXPRESSION_SYSTEM: UNIDENTIFIED BACULOVIRUS;                         
SOURCE  83 EXPRESSION_SYSTEM_TAXID: 10469;                                      
SOURCE  84 MOL_ID: 13;                                                          
SOURCE  85 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  86 ORGANISM_COMMON: HUMAN;                                              
SOURCE  87 ORGANISM_TAXID: 9606;                                                
SOURCE  88 GENE: ANAPC7, APC7;                                                  
SOURCE  89 EXPRESSION_SYSTEM: UNIDENTIFIED BACULOVIRUS;                         
SOURCE  90 EXPRESSION_SYSTEM_TAXID: 10469;                                      
SOURCE  91 MOL_ID: 14;                                                          
SOURCE  92 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  93 ORGANISM_COMMON: HUMAN;                                              
SOURCE  94 ORGANISM_TAXID: 9606;                                                
SOURCE  95 GENE: CDC23, ANAPC8;                                                 
SOURCE  96 EXPRESSION_SYSTEM: UNIDENTIFIED BACULOVIRUS;                         
SOURCE  97 EXPRESSION_SYSTEM_TAXID: 10469;                                      
SOURCE  98 MOL_ID: 15;                                                          
SOURCE  99 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE 100 ORGANISM_COMMON: HUMAN;                                              
SOURCE 101 ORGANISM_TAXID: 9606;                                                
SOURCE 102 GENE: CDC20;                                                         
SOURCE 103 EXPRESSION_SYSTEM: UNIDENTIFIED BACULOVIRUS;                         
SOURCE 104 EXPRESSION_SYSTEM_TAXID: 10469;                                      
SOURCE 105 MOL_ID: 16;                                                          
SOURCE 106 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE 107 ORGANISM_COMMON: HUMAN;                                              
SOURCE 108 ORGANISM_TAXID: 9606;                                                
SOURCE 109 GENE: CCNA2, CCN1, CCNA;                                             
SOURCE 110 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE 111 EXPRESSION_SYSTEM_TAXID: 562                                         
KEYWDS    SPINDLE ASSEMBLY CHECKPOINT, ANAPHASE-PROMOTING COMPLEX, CYCLIN,      
KEYWDS   2 UBIQUITINATION, CELL CYCLE                                           
EXPDTA    ELECTRON MICROSCOPY                                                   
AUTHOR    S.ZHANG,D.BARFORD                                                     
REVDAT   1   11-SEP-19 6Q6H    0                                                
JRNL        AUTH   S.ZHANG,T.TISCHER,D.BARFORD                                  
JRNL        TITL   CYCLIN A2 DEGRADATION DURING THE SPINDLE ASSEMBLY CHECKPOINT 
JRNL        TITL 2 REQUIRES MULTIPLE BINDING MODES TO THE APC/C.                
JRNL        REF    NAT COMMUN                    V.  10  3863 2019              
JRNL        REFN                   ESSN 2041-1723                               
JRNL        PMID   31455778                                                     
JRNL        DOI    10.1038/S41467-019-11833-2                                   
REMARK   2                                                                      
REMARK   2 RESOLUTION.    3.20 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   SOFTWARE PACKAGES      : RELION                                    
REMARK   3   RECONSTRUCTION SCHEMA  : NULL                                      
REMARK   3                                                                      
REMARK   3 EM MAP-MODEL FITTING AND REFINEMENT                                  
REMARK   3   PDB ENTRY                    : NULL                                
REMARK   3   REFINEMENT SPACE             : NULL                                
REMARK   3   REFINEMENT PROTOCOL          : NULL                                
REMARK   3   REFINEMENT TARGET            : NULL                                
REMARK   3   OVERALL ANISOTROPIC B VALUE  : NULL                                
REMARK   3                                                                      
REMARK   3 FITTING PROCEDURE : NULL                                             
REMARK   3                                                                      
REMARK   3 EM IMAGE RECONSTRUCTION STATISTICS                                   
REMARK   3   NOMINAL PIXEL SIZE (ANGSTROMS)    : NULL                           
REMARK   3   ACTUAL PIXEL SIZE  (ANGSTROMS)    : NULL                           
REMARK   3   EFFECTIVE RESOLUTION (ANGSTROMS)  : 3.200                          
REMARK   3   NUMBER OF PARTICLES               : 117044                         
REMARK   3   CTF CORRECTION METHOD             : PHASE FLIPPING AND AMPLITUDE   
REMARK   3                                       CORRECTION                     
REMARK   3                                                                      
REMARK   3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL                    
REMARK   3                                                                      
REMARK   3 OTHER DETAILS: NULL                                                  
REMARK   4                                                                      
REMARK   4 6Q6H COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 11-DEC-18.                  
REMARK 100 THE DEPOSITION ID IS D_1200013359.                                   
REMARK 245                                                                      
REMARK 245 EXPERIMENTAL DETAILS                                                 
REMARK 245   RECONSTRUCTION METHOD          : SINGLE PARTICLE                   
REMARK 245   SPECIMEN TYPE                  : NULL                              
REMARK 245                                                                      
REMARK 245 ELECTRON MICROSCOPE SAMPLE                                           
REMARK 245   SAMPLE TYPE                    : PARTICLE                          
REMARK 245   PARTICLE TYPE                  : POINT                             
REMARK 245   NAME OF SAMPLE                 : CRYO-EM STRUCTURE OF THE APC/C    
REMARK 245                                    -CDC20-CDK2-CYCLINA2-CKS2         
REMARK 245                                    COMPLEX, THE D2 BOX CLASS; CRYO-  
REMARK 245                                    EM STRUCTURE OF THE APC/C-CDC20-  
REMARK 245                                    CDK2-CYCLINA2-CKS2 COMPLEX, THE   
REMARK 245                                    D2 BOX CLASS; CRYO-EM STRUCTURE   
REMARK 245                                    OF THE APC/C-CDC20-CDK2-          
REMARK 245                                    CYCLINA2-CKS2 COMPLEX, THE D2     
REMARK 245                                    BOX CLASS                         
REMARK 245   SAMPLE CONCENTRATION (MG ML-1) : 0.15                              
REMARK 245   SAMPLE SUPPORT DETAILS         : NULL                              
REMARK 245   SAMPLE VITRIFICATION DETAILS   : NULL                              
REMARK 245   SAMPLE BUFFER                  : NULL                              
REMARK 245   PH                             : 8.00                              
REMARK 245   SAMPLE DETAILS                 : NULL                              
REMARK 245                                                                      
REMARK 245 DATA ACQUISITION                                                     
REMARK 245   DATE OF EXPERIMENT                : NULL                           
REMARK 245   NUMBER OF MICROGRAPHS-IMAGES      : NULL                           
REMARK 245   TEMPERATURE (KELVIN)              : NULL                           
REMARK 245   MICROSCOPE MODEL                  : FEI TITAN KRIOS                
REMARK 245   DETECTOR TYPE                     : GATAN K2 SUMMIT (4K X 4K)      
REMARK 245   MINIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MAXIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MINIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   MAXIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   NOMINAL CS                        : NULL                           
REMARK 245   IMAGING MODE                      : BRIGHT FIELD                   
REMARK 245   ELECTRON DOSE (ELECTRONS NM**-2)  : 28.00                          
REMARK 245   ILLUMINATION MODE                 : FLOOD BEAM                     
REMARK 245   NOMINAL MAGNIFICATION             : NULL                           
REMARK 245   CALIBRATED MAGNIFICATION          : NULL                           
REMARK 245   SOURCE                            : FIELD EMISSION GUN             
REMARK 245   ACCELERATION VOLTAGE (KV)         : 300                            
REMARK 245   IMAGING DETAILS                   : NULL                           
REMARK 247                                                                      
REMARK 247 ELECTRON MICROSCOPY                                                  
REMARK 247  THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON          
REMARK 247  MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE              
REMARK 247  THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES           
REMARK 247  ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION         
REMARK 247  OF THE STRUCTURE FACTORS.                                           
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: 21-MERIC                          
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: 21-MERIC                   
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 112190 ANGSTROM**2                        
REMARK 350 SURFACE AREA OF THE COMPLEX: 333360 ANGSTROM**2                      
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -554.0 KCAL/MOL                       
REMARK 350 APPLY THE FOLLOWING TO CHAINS: L, D, A, N, I, O, K, C, G, W,         
REMARK 350                    AND CHAINS: M, H, J, P, Q, Y, U, V, Z,            
REMARK 350                    AND CHAINS: R, S                                  
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     MET L     1                                                      
REMARK 465     THR L     2                                                      
REMARK 465     GLU L   164                                                      
REMARK 465     SER L   165                                                      
REMARK 465     SER L   166                                                      
REMARK 465     ILE L   167                                                      
REMARK 465     MET D     1                                                      
REMARK 465     ALA D    58                                                      
REMARK 465     SER D    59                                                      
REMARK 465     GLU D    60                                                      
REMARK 465     HIS D    61                                                      
REMARK 465     TYR D    62                                                      
REMARK 465     ASP D    63                                                      
REMARK 465     ASP D    64                                                      
REMARK 465     GLU D    65                                                      
REMARK 465     GLU D    66                                                      
REMARK 465     GLU D    67                                                      
REMARK 465     GLU D    68                                                      
REMARK 465     ASP D    69                                                      
REMARK 465     ASP D    70                                                      
REMARK 465     GLU D    71                                                      
REMARK 465     ASP D    72                                                      
REMARK 465     ASP D    73                                                      
REMARK 465     GLU D    74                                                      
REMARK 465     ASP D    75                                                      
REMARK 465     SER D    76                                                      
REMARK 465     GLU D    77                                                      
REMARK 465     GLU D    78                                                      
REMARK 465     ASP D    79                                                      
REMARK 465     SER D    80                                                      
REMARK 465     GLU D    81                                                      
REMARK 465     ASP D    82                                                      
REMARK 465     ASP D    83                                                      
REMARK 465     GLU D    84                                                      
REMARK 465     ASP D    85                                                      
REMARK 465     MET D    86                                                      
REMARK 465     GLN D    87                                                      
REMARK 465     ASP D    88                                                      
REMARK 465     MET D    89                                                      
REMARK 465     ASP D    90                                                      
REMARK 465     GLU D    91                                                      
REMARK 465     MET D    92                                                      
REMARK 465     ASN D    93                                                      
REMARK 465     ASP D    94                                                      
REMARK 465     TYR D    95                                                      
REMARK 465     ASN D    96                                                      
REMARK 465     GLU D    97                                                      
REMARK 465     SER D    98                                                      
REMARK 465     PRO D    99                                                      
REMARK 465     ASP D   100                                                      
REMARK 465     ASP D   101                                                      
REMARK 465     GLY D   102                                                      
REMARK 465     GLU D   103                                                      
REMARK 465     VAL D   104                                                      
REMARK 465     ASN D   105                                                      
REMARK 465     GLU D   106                                                      
REMARK 465     VAL D   107                                                      
REMARK 465     ASP D   108                                                      
REMARK 465     MET D   109                                                      
REMARK 465     GLU D   110                                                      
REMARK 465     GLY D   111                                                      
REMARK 465     ASN D   112                                                      
REMARK 465     GLU D   113                                                      
REMARK 465     GLN D   114                                                      
REMARK 465     ASP D   115                                                      
REMARK 465     GLN D   116                                                      
REMARK 465     ASP D   117                                                      
REMARK 465     GLN D   118                                                      
REMARK 465     TRP D   119                                                      
REMARK 465     MET D   120                                                      
REMARK 465     ILE D   121                                                      
REMARK 465     MET A     1                                                      
REMARK 465     SER A     2                                                      
REMARK 465     ASN A     3                                                      
REMARK 465     PHE A     4                                                      
REMARK 465     TYR A     5                                                      
REMARK 465     GLU A     6                                                      
REMARK 465     GLU A     7                                                      
REMARK 465     ARG A     8                                                      
REMARK 465     THR A     9                                                      
REMARK 465     SER A    50                                                      
REMARK 465     SER A    51                                                      
REMARK 465     ASP A    52                                                      
REMARK 465     GLY A    53                                                      
REMARK 465     ALA A    54                                                      
REMARK 465     ALA A    55                                                      
REMARK 465     GLY A    56                                                      
REMARK 465     LEU A    57                                                      
REMARK 465     VAL A    58                                                      
REMARK 465     GLY A    59                                                      
REMARK 465     SER A    60                                                      
REMARK 465     LEU A    61                                                      
REMARK 465     GLN A    62                                                      
REMARK 465     GLU A    63                                                      
REMARK 465     VAL A    64                                                      
REMARK 465     THR A    65                                                      
REMARK 465     ILE A    66                                                      
REMARK 465     HIS A    67                                                      
REMARK 465     GLU A    68                                                      
REMARK 465     LYS A    69                                                      
REMARK 465     GLN A    70                                                      
REMARK 465     SER A   194                                                      
REMARK 465     SER A   195                                                      
REMARK 465     HIS A   196                                                      
REMARK 465     GLU A   197                                                      
REMARK 465     VAL A   198                                                      
REMARK 465     PRO A   199                                                      
REMARK 465     PRO A   200                                                      
REMARK 465     GLY A   201                                                      
REMARK 465     SER A   202                                                      
REMARK 465     PRO A   203                                                      
REMARK 465     ARG A   204                                                      
REMARK 465     GLY A   228                                                      
REMARK 465     SER A   229                                                      
REMARK 465     LEU A   230                                                      
REMARK 465     PHE A   231                                                      
REMARK 465     GLY A   232                                                      
REMARK 465     SER A   233                                                      
REMARK 465     SER A   234                                                      
REMARK 465     ARG A   235                                                      
REMARK 465     VAL A   370                                                      
REMARK 465     VAL A   371                                                      
REMARK 465     LEU A   372                                                      
REMARK 465     LYS A   373                                                      
REMARK 465     PHE A   374                                                      
REMARK 465     SER A   375                                                      
REMARK 465     GLU A   376                                                      
REMARK 465     GLN A   377                                                      
REMARK 465     GLY A   378                                                      
REMARK 465     GLY A   379                                                      
REMARK 465     THR A   380                                                      
REMARK 465     PRO A   381                                                      
REMARK 465     GLN A   382                                                      
REMARK 465     ASN A   383                                                      
REMARK 465     VAL A   384                                                      
REMARK 465     ALA A   385                                                      
REMARK 465     THR A   386                                                      
REMARK 465     SER A   387                                                      
REMARK 465     SER A   388                                                      
REMARK 465     SER A   389                                                      
REMARK 465     LEU A   390                                                      
REMARK 465     THR A   391                                                      
REMARK 465     ALA A   392                                                      
REMARK 465     HIS A   393                                                      
REMARK 465     LEU A   394                                                      
REMARK 465     ARG A   395                                                      
REMARK 465     LEU A   396                                                      
REMARK 465     ALA A   397                                                      
REMARK 465     PRO A   398                                                      
REMARK 465     GLU A   399                                                      
REMARK 465     ILE A   417                                                      
REMARK 465     THR A   418                                                      
REMARK 465     ASN A   419                                                      
REMARK 465     ILE A   420                                                      
REMARK 465     ARG A   421                                                      
REMARK 465     GLU A   422                                                      
REMARK 465     ALA A   516                                                      
REMARK 465     PRO A   517                                                      
REMARK 465     SER A   518                                                      
REMARK 465     LEU A   519                                                      
REMARK 465     THR A   520                                                      
REMARK 465     MET A   521                                                      
REMARK 465     SER A   522                                                      
REMARK 465     ASN A   523                                                      
REMARK 465     THR A   524                                                      
REMARK 465     MET A   525                                                      
REMARK 465     PRO A   526                                                      
REMARK 465     ARG A   527                                                      
REMARK 465     PRO A   528                                                      
REMARK 465     SER A   529                                                      
REMARK 465     THR A   530                                                      
REMARK 465     PRO A   531                                                      
REMARK 465     LEU A   532                                                      
REMARK 465     ASP A   533                                                      
REMARK 465     GLY A   534                                                      
REMARK 465     VAL A   535                                                      
REMARK 465     SER A   536                                                      
REMARK 465     THR A   537                                                      
REMARK 465     PRO A   538                                                      
REMARK 465     LYS A   539                                                      
REMARK 465     PRO A   540                                                      
REMARK 465     LEU A   541                                                      
REMARK 465     SER A   542                                                      
REMARK 465     LYS A   543                                                      
REMARK 465     LEU A   544                                                      
REMARK 465     LEU A   545                                                      
REMARK 465     GLY A   546                                                      
REMARK 465     SER A   547                                                      
REMARK 465     LEU A   548                                                      
REMARK 465     ASP A   549                                                      
REMARK 465     GLU A   550                                                      
REMARK 465     VAL A   551                                                      
REMARK 465     VAL A   552                                                      
REMARK 465     LEU A   553                                                      
REMARK 465     LEU A   554                                                      
REMARK 465     SER A   555                                                      
REMARK 465     PRO A   556                                                      
REMARK 465     VAL A   557                                                      
REMARK 465     PRO A   558                                                      
REMARK 465     GLU A   559                                                      
REMARK 465     LEU A   560                                                      
REMARK 465     ARG A   561                                                      
REMARK 465     ASP A   562                                                      
REMARK 465     SER A   563                                                      
REMARK 465     SER A   564                                                      
REMARK 465     LYS A   565                                                      
REMARK 465     LEU A   566                                                      
REMARK 465     HIS A   567                                                      
REMARK 465     ASP A   568                                                      
REMARK 465     SER A   569                                                      
REMARK 465     LEU A   570                                                      
REMARK 465     TYR A   571                                                      
REMARK 465     ASN A   572                                                      
REMARK 465     GLU A   573                                                      
REMARK 465     ASP A   574                                                      
REMARK 465     CYS A   575                                                      
REMARK 465     THR A   576                                                      
REMARK 465     PHE A   577                                                      
REMARK 465     GLN A   578                                                      
REMARK 465     GLN A   579                                                      
REMARK 465     LEU A   580                                                      
REMARK 465     GLY A   581                                                      
REMARK 465     THR A   678                                                      
REMARK 465     ARG A   679                                                      
REMARK 465     ASN A   680                                                      
REMARK 465     PHE A   681                                                      
REMARK 465     ASP A   682                                                      
REMARK 465     PHE A   683                                                      
REMARK 465     GLU A   684                                                      
REMARK 465     GLY A   685                                                      
REMARK 465     SER A   686                                                      
REMARK 465     LEU A   687                                                      
REMARK 465     SER A   688                                                      
REMARK 465     PRO A   689                                                      
REMARK 465     VAL A   690                                                      
REMARK 465     ILE A   691                                                      
REMARK 465     ALA A   692                                                      
REMARK 465     PRO A   693                                                      
REMARK 465     LYS A   694                                                      
REMARK 465     LYS A   695                                                      
REMARK 465     ALA A   696                                                      
REMARK 465     ARG A   697                                                      
REMARK 465     PRO A   698                                                      
REMARK 465     SER A   699                                                      
REMARK 465     GLU A   700                                                      
REMARK 465     THR A   701                                                      
REMARK 465     GLY A   702                                                      
REMARK 465     GLU A   734                                                      
REMARK 465     ALA A   735                                                      
REMARK 465     SER A   736                                                      
REMARK 465     GLN A   737                                                      
REMARK 465     MET A   738                                                      
REMARK 465     LYS A   739                                                      
REMARK 465     ASP A   740                                                      
REMARK 465     GLU A   741                                                      
REMARK 465     ASP A   742                                                      
REMARK 465     PHE A   743                                                      
REMARK 465     SER A   744                                                      
REMARK 465     GLN A   745                                                      
REMARK 465     PRO A   825                                                      
REMARK 465     GLY A   826                                                      
REMARK 465     GLN A   827                                                      
REMARK 465     THR A   828                                                      
REMARK 465     GLU A   885                                                      
REMARK 465     SER A   886                                                      
REMARK 465     LEU A   887                                                      
REMARK 465     VAL A   888                                                      
REMARK 465     SER A   889                                                      
REMARK 465     ASP A   890                                                      
REMARK 465     GLU A   891                                                      
REMARK 465     ILE A   901                                                      
REMARK 465     ALA A   902                                                      
REMARK 465     PRO A   903                                                      
REMARK 465     GLN A   904                                                      
REMARK 465     LYS A   905                                                      
REMARK 465     LEU A   906                                                      
REMARK 465     GLN A   907                                                      
REMARK 465     VAL A   908                                                      
REMARK 465     GLU A   909                                                      
REMARK 465     GLN A   910                                                      
REMARK 465     GLU A   911                                                      
REMARK 465     GLU A   912                                                      
REMARK 465     ASN A   913                                                      
REMARK 465     ARG A   914                                                      
REMARK 465     PHE A   915                                                      
REMARK 465     SER A   916                                                      
REMARK 465     PHE A   917                                                      
REMARK 465     ARG A   918                                                      
REMARK 465     HIS A   919                                                      
REMARK 465     SER A   920                                                      
REMARK 465     THR A   921                                                      
REMARK 465     SER A   922                                                      
REMARK 465     VAL A   923                                                      
REMARK 465     CYS A   988                                                      
REMARK 465     GLU A   989                                                      
REMARK 465     GLY A   990                                                      
REMARK 465     ASN A   991                                                      
REMARK 465     LEU A   992                                                      
REMARK 465     PRO A   993                                                      
REMARK 465     LYS A   994                                                      
REMARK 465     GLY A   995                                                      
REMARK 465     LYS A   996                                                      
REMARK 465     SER A   997                                                      
REMARK 465     VAL A   998                                                      
REMARK 465     LEU A   999                                                      
REMARK 465     SER A  1000                                                      
REMARK 465     SER A  1001                                                      
REMARK 465     ASP A  1002                                                      
REMARK 465     VAL A  1003                                                      
REMARK 465     PRO A  1004                                                      
REMARK 465     SER A  1005                                                      
REMARK 465     GLY A  1006                                                      
REMARK 465     THR A  1007                                                      
REMARK 465     GLU A  1008                                                      
REMARK 465     THR A  1009                                                      
REMARK 465     PHE A  1336                                                      
REMARK 465     GLN A  1337                                                      
REMARK 465     THR A  1338                                                      
REMARK 465     GLY A  1339                                                      
REMARK 465     MET A  1340                                                      
REMARK 465     HIS A  1341                                                      
REMARK 465     ARG A  1342                                                      
REMARK 465     GLU A  1343                                                      
REMARK 465     LYS A  1344                                                      
REMARK 465     HIS A  1345                                                      
REMARK 465     LYS A  1346                                                      
REMARK 465     ILE A  1439                                                      
REMARK 465     SER A  1440                                                      
REMARK 465     LEU A  1441                                                      
REMARK 465     SER A  1442                                                      
REMARK 465     GLU A  1443                                                      
REMARK 465     ILE A  1444                                                      
REMARK 465     GLU A  1445                                                      
REMARK 465     LEU A  1446                                                      
REMARK 465     PRO A  1447                                                      
REMARK 465     CYS A  1448                                                      
REMARK 465     SER A  1449                                                      
REMARK 465     GLU A  1450                                                      
REMARK 465     ASP A  1451                                                      
REMARK 465     GLY A  1714                                                      
REMARK 465     TRP A  1715                                                      
REMARK 465     GLN A  1716                                                      
REMARK 465     SER A  1717                                                      
REMARK 465     LEU A  1718                                                      
REMARK 465     LEU A  1719                                                      
REMARK 465     ALA A  1720                                                      
REMARK 465     GLN A  1721                                                      
REMARK 465     THR A  1722                                                      
REMARK 465     VAL A  1723                                                      
REMARK 465     ALA A  1724                                                      
REMARK 465     LEU A  1830                                                      
REMARK 465     GLN A  1831                                                      
REMARK 465     ASN A  1832                                                      
REMARK 465     HIS A  1833                                                      
REMARK 465     PRO A  1834                                                      
REMARK 465     LYS A  1835                                                      
REMARK 465     ARG A  1836                                                      
REMARK 465     GLY A  1837                                                      
REMARK 465     LEU A  1838                                                      
REMARK 465     PRO A  1902                                                      
REMARK 465     ILE A  1903                                                      
REMARK 465     GLY A  1904                                                      
REMARK 465     LEU A  1905                                                      
REMARK 465     GLU A  1906                                                      
REMARK 465     GLY A  1907                                                      
REMARK 465     SER A  1908                                                      
REMARK 465     THR A  1909                                                      
REMARK 465     GLY A  1937                                                      
REMARK 465     ASN A  1938                                                      
REMARK 465     PRO A  1939                                                      
REMARK 465     GLN A  1940                                                      
REMARK 465     PRO A  1941                                                      
REMARK 465     MET A  1942                                                      
REMARK 465     VAL A  1943                                                      
REMARK 465     MET A  1944                                                      
REMARK 465     MET N     1                                                      
REMARK 465     ALA N     2                                                      
REMARK 465     ALA N     3                                                      
REMARK 465     ALA N     4                                                      
REMARK 465     VAL N     5                                                      
REMARK 465     VAL N     6                                                      
REMARK 465     VAL N     7                                                      
REMARK 465     ALA N     8                                                      
REMARK 465     GLU N     9                                                      
REMARK 465     GLY N    10                                                      
REMARK 465     ASP N    11                                                      
REMARK 465     SER N    12                                                      
REMARK 465     ASP N    13                                                      
REMARK 465     SER N    14                                                      
REMARK 465     ARG N    15                                                      
REMARK 465     ALA N    35                                                      
REMARK 465     ALA N    36                                                      
REMARK 465     LEU N    37                                                      
REMARK 465     GLY N    38                                                      
REMARK 465     LEU N    39                                                      
REMARK 465     VAL N    40                                                      
REMARK 465     SER N    41                                                      
REMARK 465     SER N    42                                                      
REMARK 465     ARG N    43                                                      
REMARK 465     THR N    44                                                      
REMARK 465     SER N    45                                                      
REMARK 465     GLY N    46                                                      
REMARK 465     ALA N    47                                                      
REMARK 465     VAL N    48                                                      
REMARK 465     PRO N    49                                                      
REMARK 465     PRO N    50                                                      
REMARK 465     LEU N   199                                                      
REMARK 465     GLU N   200                                                      
REMARK 465     GLY N   201                                                      
REMARK 465     GLU N   202                                                      
REMARK 465     LEU N   203                                                      
REMARK 465     ASP N   204                                                      
REMARK 465     SER N   205                                                      
REMARK 465     CYS N   221                                                      
REMARK 465     ALA N   222                                                      
REMARK 465     GLY N   223                                                      
REMARK 465     CYS N   224                                                      
REMARK 465     SER N   225                                                      
REMARK 465     SER N   226                                                      
REMARK 465     ASP N   227                                                      
REMARK 465     LYS N   228                                                      
REMARK 465     GLN N   229                                                      
REMARK 465     GLN N   230                                                      
REMARK 465     CYS N   231                                                      
REMARK 465     ASP N   307                                                      
REMARK 465     GLY N   308                                                      
REMARK 465     PRO N   309                                                      
REMARK 465     ALA N   310                                                      
REMARK 465     ARG N   311                                                      
REMARK 465     PRO N   312                                                      
REMARK 465     ALA N   313                                                      
REMARK 465     SER N   457                                                      
REMARK 465     LYS N   458                                                      
REMARK 465     THR N   459                                                      
REMARK 465     ASP N   460                                                      
REMARK 465     PRO N   461                                                      
REMARK 465     ALA N   462                                                      
REMARK 465     SER N   463                                                      
REMARK 465     LEU N   464                                                      
REMARK 465     GLU N   465                                                      
REMARK 465     THR N   466                                                      
REMARK 465     GLY N   467                                                      
REMARK 465     GLN N   468                                                      
REMARK 465     ASP N   469                                                      
REMARK 465     SER N   470                                                      
REMARK 465     GLU N   471                                                      
REMARK 465     ASP N   472                                                      
REMARK 465     LYS N   491                                                      
REMARK 465     SER N   492                                                      
REMARK 465     SER N   493                                                      
REMARK 465     SER N   494                                                      
REMARK 465     LYS N   495                                                      
REMARK 465     ASP N   731                                                      
REMARK 465     SER N   732                                                      
REMARK 465     ASP N   733                                                      
REMARK 465     ASP N   734                                                      
REMARK 465     GLU N   735                                                      
REMARK 465     SER N   736                                                      
REMARK 465     ASP N   737                                                      
REMARK 465     SER N   738                                                      
REMARK 465     GLY N   739                                                      
REMARK 465     MET N   740                                                      
REMARK 465     ALA N   741                                                      
REMARK 465     SER N   742                                                      
REMARK 465     GLN N   743                                                      
REMARK 465     ALA N   744                                                      
REMARK 465     ASP N   745                                                      
REMARK 465     GLN N   746                                                      
REMARK 465     LYS N   747                                                      
REMARK 465     GLU N   748                                                      
REMARK 465     GLU N   749                                                      
REMARK 465     GLU N   750                                                      
REMARK 465     LEU N   751                                                      
REMARK 465     LEU N   752                                                      
REMARK 465     LEU N   753                                                      
REMARK 465     PHE N   754                                                      
REMARK 465     TRP N   755                                                      
REMARK 465     THR N   756                                                      
REMARK 465     TYR N   757                                                      
REMARK 465     ILE N   758                                                      
REMARK 465     GLN N   759                                                      
REMARK 465     ALA N   760                                                      
REMARK 465     MET N   761                                                      
REMARK 465     LEU N   762                                                      
REMARK 465     THR N   763                                                      
REMARK 465     ASN N   764                                                      
REMARK 465     LEU N   765                                                      
REMARK 465     GLU N   766                                                      
REMARK 465     SER N   767                                                      
REMARK 465     LEU N   768                                                      
REMARK 465     SER N   769                                                      
REMARK 465     LEU N   770                                                      
REMARK 465     ASP N   771                                                      
REMARK 465     ARG N   772                                                      
REMARK 465     ILE N   773                                                      
REMARK 465     TYR N   774                                                      
REMARK 465     ASN N   775                                                      
REMARK 465     MET N   776                                                      
REMARK 465     LEU N   777                                                      
REMARK 465     ARG N   778                                                      
REMARK 465     MET N   779                                                      
REMARK 465     PHE N   780                                                      
REMARK 465     VAL N   781                                                      
REMARK 465     VAL N   782                                                      
REMARK 465     THR N   783                                                      
REMARK 465     GLY N   784                                                      
REMARK 465     PRO N   785                                                      
REMARK 465     ALA N   786                                                      
REMARK 465     LEU N   787                                                      
REMARK 465     ALA N   788                                                      
REMARK 465     GLU N   789                                                      
REMARK 465     ILE N   790                                                      
REMARK 465     ASP N   791                                                      
REMARK 465     LEU N   792                                                      
REMARK 465     GLN N   793                                                      
REMARK 465     GLU N   794                                                      
REMARK 465     LEU N   795                                                      
REMARK 465     GLN N   796                                                      
REMARK 465     GLY N   797                                                      
REMARK 465     TYR N   798                                                      
REMARK 465     LEU N   799                                                      
REMARK 465     GLN N   800                                                      
REMARK 465     LYS N   801                                                      
REMARK 465     LYS N   802                                                      
REMARK 465     VAL N   803                                                      
REMARK 465     ARG N   804                                                      
REMARK 465     ASP N   805                                                      
REMARK 465     GLN N   806                                                      
REMARK 465     GLN N   807                                                      
REMARK 465     LEU N   808                                                      
REMARK 465     VAL N   809                                                      
REMARK 465     TYR N   810                                                      
REMARK 465     SER N   811                                                      
REMARK 465     ALA N   812                                                      
REMARK 465     GLY N   813                                                      
REMARK 465     VAL N   814                                                      
REMARK 465     TYR N   815                                                      
REMARK 465     ARG N   816                                                      
REMARK 465     LEU N   817                                                      
REMARK 465     PRO N   818                                                      
REMARK 465     LYS N   819                                                      
REMARK 465     ASN N   820                                                      
REMARK 465     CYS N   821                                                      
REMARK 465     SER N   822                                                      
REMARK 465     MET I     1                                                      
REMARK 465     LEU I     2                                                      
REMARK 465     ARG I     3                                                      
REMARK 465     PHE I     4                                                      
REMARK 465     PRO I     5                                                      
REMARK 465     ASN I   130                                                      
REMARK 465     ALA I   131                                                      
REMARK 465     GLU I   132                                                      
REMARK 465     ASP I   133                                                      
REMARK 465     ASP I   431                                                      
REMARK 465     HIS I   432                                                      
REMARK 465     VAL I   433                                                      
REMARK 465     LEU I   434                                                      
REMARK 465     PRO I   435                                                      
REMARK 465     GLU I   436                                                      
REMARK 465     LEU I   437                                                      
REMARK 465     ASN I   438                                                      
REMARK 465     GLU I   458                                                      
REMARK 465     ALA I   459                                                      
REMARK 465     PRO I   460                                                      
REMARK 465     ASP I   461                                                      
REMARK 465     LEU I   462                                                      
REMARK 465     TYR I   463                                                      
REMARK 465     ASN I   464                                                      
REMARK 465     ARG I   465                                                      
REMARK 465     LYS I   466                                                      
REMARK 465     GLY I   467                                                      
REMARK 465     LYS I   468                                                      
REMARK 465     SER I   758                                                      
REMARK 465     ASP I   759                                                      
REMARK 465     GLU I   760                                                      
REMARK 465     GLU I   761                                                      
REMARK 465     GLU I   762                                                      
REMARK 465     GLU I   763                                                      
REMARK 465     ALA I   764                                                      
REMARK 465     SER I   765                                                      
REMARK 465     ASN I   766                                                      
REMARK 465     LYS I   767                                                      
REMARK 465     PRO I   768                                                      
REMARK 465     VAL I   769                                                      
REMARK 465     LYS I   770                                                      
REMARK 465     ILE I   771                                                      
REMARK 465     LYS I   772                                                      
REMARK 465     GLU I   773                                                      
REMARK 465     GLU I   774                                                      
REMARK 465     VAL I   775                                                      
REMARK 465     LEU I   776                                                      
REMARK 465     SER I   777                                                      
REMARK 465     GLU I   778                                                      
REMARK 465     SER I   779                                                      
REMARK 465     GLU I   780                                                      
REMARK 465     ALA I   781                                                      
REMARK 465     GLU I   782                                                      
REMARK 465     ASN I   783                                                      
REMARK 465     GLN I   784                                                      
REMARK 465     GLN I   785                                                      
REMARK 465     ALA I   786                                                      
REMARK 465     GLY I   787                                                      
REMARK 465     ALA I   788                                                      
REMARK 465     ALA I   789                                                      
REMARK 465     ALA I   790                                                      
REMARK 465     LEU I   791                                                      
REMARK 465     ALA I   792                                                      
REMARK 465     PRO I   793                                                      
REMARK 465     GLU I   794                                                      
REMARK 465     ILE I   795                                                      
REMARK 465     VAL I   796                                                      
REMARK 465     ILE I   797                                                      
REMARK 465     LYS I   798                                                      
REMARK 465     VAL I   799                                                      
REMARK 465     GLU I   800                                                      
REMARK 465     LYS I   801                                                      
REMARK 465     LEU I   802                                                      
REMARK 465     ASP I   803                                                      
REMARK 465     PRO I   804                                                      
REMARK 465     GLU I   805                                                      
REMARK 465     LEU I   806                                                      
REMARK 465     ASP I   807                                                      
REMARK 465     SER I   808                                                      
REMARK 465     MET O     1                                                      
REMARK 465     ALA O     2                                                      
REMARK 465     SER O     3                                                      
REMARK 465     VAL O     4                                                      
REMARK 465     HIS O     5                                                      
REMARK 465     GLU O     6                                                      
REMARK 465     SER O     7                                                      
REMARK 465     LEU O     8                                                      
REMARK 465     ALA O    21                                                      
REMARK 465     ASN O    22                                                      
REMARK 465     VAL O    23                                                      
REMARK 465     PHE O    24                                                      
REMARK 465     VAL O   170                                                      
REMARK 465     GLU O   171                                                      
REMARK 465     ASP O   172                                                      
REMARK 465     ALA O   173                                                      
REMARK 465     ASP O   174                                                      
REMARK 465     MET O   175                                                      
REMARK 465     GLU O   176                                                      
REMARK 465     LEU O   177                                                      
REMARK 465     THR O   178                                                      
REMARK 465     SER O   179                                                      
REMARK 465     ARG O   180                                                      
REMARK 465     ASP O   181                                                      
REMARK 465     GLU O   182                                                      
REMARK 465     GLY O   183                                                      
REMARK 465     GLU O   184                                                      
REMARK 465     ARG O   185                                                      
REMARK 465     LYS O   186                                                      
REMARK 465     MET O   187                                                      
REMARK 465     GLU O   188                                                      
REMARK 465     LYS O   189                                                      
REMARK 465     GLU O   190                                                      
REMARK 465     GLU O   191                                                      
REMARK 465     LEU O   192                                                      
REMARK 465     ASP O   193                                                      
REMARK 465     VAL O   194                                                      
REMARK 465     SER O   195                                                      
REMARK 465     VAL O   196                                                      
REMARK 465     ARG O   197                                                      
REMARK 465     GLU O   198                                                      
REMARK 465     GLU O   199                                                      
REMARK 465     GLU O   200                                                      
REMARK 465     VAL O   201                                                      
REMARK 465     SER O   202                                                      
REMARK 465     CYS O   203                                                      
REMARK 465     SER O   204                                                      
REMARK 465     GLY O   205                                                      
REMARK 465     VAL O   454                                                      
REMARK 465     ASN O   455                                                      
REMARK 465     ALA O   456                                                      
REMARK 465     GLY O   457                                                      
REMARK 465     MET K     1                                                      
REMARK 465     MET K    95                                                      
REMARK 465     GLU K    96                                                      
REMARK 465     GLU K    97                                                      
REMARK 465     PRO K    98                                                      
REMARK 465     ILE K    99                                                      
REMARK 465     ASN K   100                                                      
REMARK 465     LYS K   101                                                      
REMARK 465     ARG K   102                                                      
REMARK 465     LEU K   103                                                      
REMARK 465     PHE K   104                                                      
REMARK 465     GLU K   105                                                      
REMARK 465     LYS K   106                                                      
REMARK 465     TYR K   107                                                      
REMARK 465     LEU K   108                                                      
REMARK 465     LYS K   109                                                      
REMARK 465     ASP K   110                                                      
REMARK 465     GLU K   111                                                      
REMARK 465     SER K   112                                                      
REMARK 465     GLY K   113                                                      
REMARK 465     PHE K   114                                                      
REMARK 465     LYS K   115                                                      
REMARK 465     ASP K   116                                                      
REMARK 465     PRO K   117                                                      
REMARK 465     SER K   118                                                      
REMARK 465     SER K   119                                                      
REMARK 465     ASP K   120                                                      
REMARK 465     TRP K   121                                                      
REMARK 465     GLU K   122                                                      
REMARK 465     MET K   123                                                      
REMARK 465     SER K   124                                                      
REMARK 465     GLN K   125                                                      
REMARK 465     SER K   126                                                      
REMARK 465     ASP K   529                                                      
REMARK 465     SER K   530                                                      
REMARK 465     GLU K   531                                                      
REMARK 465     ALA K   532                                                      
REMARK 465     TYR K   533                                                      
REMARK 465     ILE K   534                                                      
REMARK 465     GLY K   535                                                      
REMARK 465     ALA K   536                                                      
REMARK 465     ASP K   537                                                      
REMARK 465     ILE K   538                                                      
REMARK 465     LYS K   539                                                      
REMARK 465     ASP K   540                                                      
REMARK 465     LYS K   541                                                      
REMARK 465     LEU K   542                                                      
REMARK 465     LYS K   543                                                      
REMARK 465     GLU K   567                                                      
REMARK 465     PHE K   568                                                      
REMARK 465     GLU K   569                                                      
REMARK 465     VAL K   570                                                      
REMARK 465     GLU K   571                                                      
REMARK 465     LYS K   572                                                      
REMARK 465     GLN K   573                                                      
REMARK 465     THR K   574                                                      
REMARK 465     ALA K   575                                                      
REMARK 465     GLU K   576                                                      
REMARK 465     GLU K   577                                                      
REMARK 465     THR K   578                                                      
REMARK 465     GLY K   579                                                      
REMARK 465     LEU K   580                                                      
REMARK 465     THR K   581                                                      
REMARK 465     PRO K   582                                                      
REMARK 465     LEU K   583                                                      
REMARK 465     GLU K   584                                                      
REMARK 465     THR K   585                                                      
REMARK 465     SER K   586                                                      
REMARK 465     ARG K   587                                                      
REMARK 465     LYS K   588                                                      
REMARK 465     THR K   589                                                      
REMARK 465     PRO K   590                                                      
REMARK 465     ASP K   591                                                      
REMARK 465     SER K   592                                                      
REMARK 465     ARG K   593                                                      
REMARK 465     PRO K   594                                                      
REMARK 465     SER K   595                                                      
REMARK 465     LEU K   596                                                      
REMARK 465     GLU K   597                                                      
REMARK 465     GLU K   598                                                      
REMARK 465     THR K   599                                                      
REMARK 465     PHE K   600                                                      
REMARK 465     GLU K   601                                                      
REMARK 465     ILE K   602                                                      
REMARK 465     GLU K   603                                                      
REMARK 465     MET K   604                                                      
REMARK 465     ASN K   605                                                      
REMARK 465     GLU K   606                                                      
REMARK 465     SER K   607                                                      
REMARK 465     ASP K   608                                                      
REMARK 465     MET K   609                                                      
REMARK 465     MET K   610                                                      
REMARK 465     LEU K   611                                                      
REMARK 465     GLU K   612                                                      
REMARK 465     THR K   613                                                      
REMARK 465     SER K   614                                                      
REMARK 465     MET K   615                                                      
REMARK 465     SER K   616                                                      
REMARK 465     ASP K   617                                                      
REMARK 465     HIS K   618                                                      
REMARK 465     SER K   619                                                      
REMARK 465     THR K   620                                                      
REMARK 465     THR G    28                                                      
REMARK 465     ARG G    29                                                      
REMARK 465     LYS G    30                                                      
REMARK 465     LYS G    31                                                      
REMARK 465     GLN G    32                                                      
REMARK 465     LYS G    33                                                      
REMARK 465     GLU G    34                                                      
REMARK 465     ASP G    35                                                      
REMARK 465     VAL G    36                                                      
REMARK 465     GLU G    37                                                      
REMARK 465     VAL G    38                                                      
REMARK 465     VAL G    39                                                      
REMARK 465     GLY G    40                                                      
REMARK 465     GLY G    41                                                      
REMARK 465     SER G    42                                                      
REMARK 465     ASP G    43                                                      
REMARK 465     GLY G    44                                                      
REMARK 465     GLU G    45                                                      
REMARK 465     GLY G    46                                                      
REMARK 465     ALA G    47                                                      
REMARK 465     ILE G    48                                                      
REMARK 465     GLY G    49                                                      
REMARK 465     LEU G    50                                                      
REMARK 465     SER G    51                                                      
REMARK 465     SER G    52                                                      
REMARK 465     ASP G    53                                                      
REMARK 465     PRO G    54                                                      
REMARK 465     LYS G    55                                                      
REMARK 465     SER G    56                                                      
REMARK 465     ARG G    57                                                      
REMARK 465     GLU G    58                                                      
REMARK 465     GLN G    59                                                      
REMARK 465     MET G    60                                                      
REMARK 465     ILE G    61                                                      
REMARK 465     ASN G    62                                                      
REMARK 465     ASP G    63                                                      
REMARK 465     ARG G    64                                                      
REMARK 465     ILE G    65                                                      
REMARK 465     GLY G    66                                                      
REMARK 465     TYR G    67                                                      
REMARK 465     LYS G    68                                                      
REMARK 465     PRO G    69                                                      
REMARK 465     GLN G    70                                                      
REMARK 465     PRO G    71                                                      
REMARK 465     LYS G    72                                                      
REMARK 465     PRO G    73                                                      
REMARK 465     ASN G    74                                                      
REMARK 465     ASN G    75                                                      
REMARK 465     ARG G    76                                                      
REMARK 465     SER G    77                                                      
REMARK 465     SER G    78                                                      
REMARK 465     GLN G    79                                                      
REMARK 465     PHE G    80                                                      
REMARK 465     GLY G    81                                                      
REMARK 465     SER G    82                                                      
REMARK 465     LEU G    83                                                      
REMARK 465     GLU G    84                                                      
REMARK 465     PHE G    85                                                      
REMARK 465     GLU W    27                                                      
REMARK 465     THR W    28                                                      
REMARK 465     ARG W    29                                                      
REMARK 465     LYS W    30                                                      
REMARK 465     LYS W    31                                                      
REMARK 465     GLN W    32                                                      
REMARK 465     LYS W    33                                                      
REMARK 465     GLU W    34                                                      
REMARK 465     ASP W    35                                                      
REMARK 465     VAL W    36                                                      
REMARK 465     GLU W    37                                                      
REMARK 465     VAL W    38                                                      
REMARK 465     VAL W    39                                                      
REMARK 465     GLY W    40                                                      
REMARK 465     GLY W    41                                                      
REMARK 465     SER W    42                                                      
REMARK 465     ASP W    43                                                      
REMARK 465     GLY W    44                                                      
REMARK 465     GLU W    45                                                      
REMARK 465     GLY W    46                                                      
REMARK 465     ALA W    47                                                      
REMARK 465     ILE W    48                                                      
REMARK 465     GLY W    49                                                      
REMARK 465     LEU W    50                                                      
REMARK 465     SER W    51                                                      
REMARK 465     SER W    52                                                      
REMARK 465     ASP W    53                                                      
REMARK 465     PRO W    54                                                      
REMARK 465     LYS W    55                                                      
REMARK 465     SER W    56                                                      
REMARK 465     ARG W    57                                                      
REMARK 465     GLU W    58                                                      
REMARK 465     GLN W    59                                                      
REMARK 465     MET W    60                                                      
REMARK 465     ILE W    61                                                      
REMARK 465     ASN W    62                                                      
REMARK 465     ASP W    63                                                      
REMARK 465     ARG W    64                                                      
REMARK 465     ILE W    65                                                      
REMARK 465     GLY W    66                                                      
REMARK 465     TYR W    67                                                      
REMARK 465     LYS W    68                                                      
REMARK 465     PRO W    69                                                      
REMARK 465     GLN W    70                                                      
REMARK 465     PRO W    71                                                      
REMARK 465     LYS W    72                                                      
REMARK 465     PRO W    73                                                      
REMARK 465     ASN W    74                                                      
REMARK 465     ASN W    75                                                      
REMARK 465     ARG W    76                                                      
REMARK 465     SER W    77                                                      
REMARK 465     SER W    78                                                      
REMARK 465     GLN W    79                                                      
REMARK 465     PHE W    80                                                      
REMARK 465     GLY W    81                                                      
REMARK 465     SER W    82                                                      
REMARK 465     LEU W    83                                                      
REMARK 465     GLU W    84                                                      
REMARK 465     PHE W    85                                                      
REMARK 465     GLU M    40                                                      
REMARK 465     GLN M    41                                                      
REMARK 465     ASP M    42                                                      
REMARK 465     ASN M    43                                                      
REMARK 465     GLY M    44                                                      
REMARK 465     GLY M    45                                                      
REMARK 465     ASN M    68                                                      
REMARK 465     VAL M    69                                                      
REMARK 465     PRO M    70                                                      
REMARK 465     PRO M    71                                                      
REMARK 465     ILE M    72                                                      
REMARK 465     GLY M    73                                                      
REMARK 465     ASN M    74                                                      
REMARK 465     MET H     1                                                      
REMARK 465     ALA H     2                                                      
REMARK 465     ALA H     3                                                      
REMARK 465     SER H     4                                                      
REMARK 465     SER H     5                                                      
REMARK 465     SER H     6                                                      
REMARK 465     SER H     7                                                      
REMARK 465     SER H     8                                                      
REMARK 465     SER H     9                                                      
REMARK 465     ALA H    10                                                      
REMARK 465     GLY H    11                                                      
REMARK 465     GLY H    12                                                      
REMARK 465     VAL H    13                                                      
REMARK 465     SER H    14                                                      
REMARK 465     GLY H    15                                                      
REMARK 465     SER H    16                                                      
REMARK 465     SER H    17                                                      
REMARK 465     VAL H    18                                                      
REMARK 465     THR H    19                                                      
REMARK 465     GLY H    20                                                      
REMARK 465     SER H    21                                                      
REMARK 465     GLY H    22                                                      
REMARK 465     PHE H    23                                                      
REMARK 465     SER H    24                                                      
REMARK 465     VAL H    25                                                      
REMARK 465     SER H    26                                                      
REMARK 465     ASP H    27                                                      
REMARK 465     LEU H    28                                                      
REMARK 465     ALA H    29                                                      
REMARK 465     PRO H    30                                                      
REMARK 465     PRO H    31                                                      
REMARK 465     ARG H    32                                                      
REMARK 465     LYS H    33                                                      
REMARK 465     ALA H    34                                                      
REMARK 465     LEU H    35                                                      
REMARK 465     PHE H    36                                                      
REMARK 465     THR H    37                                                      
REMARK 465     TYR H    38                                                      
REMARK 465     PRO H    39                                                      
REMARK 465     LYS H    40                                                      
REMARK 465     GLY H    41                                                      
REMARK 465     ALA H    42                                                      
REMARK 465     GLY H    43                                                      
REMARK 465     GLU H    44                                                      
REMARK 465     MET H    45                                                      
REMARK 465     LEU H    46                                                      
REMARK 465     GLU H    47                                                      
REMARK 465     ASP H    48                                                      
REMARK 465     GLY H    49                                                      
REMARK 465     SER H    50                                                      
REMARK 465     SER H   108                                                      
REMARK 465     SER H   109                                                      
REMARK 465     GLY H   110                                                      
REMARK 465     MET J     1                                                      
REMARK 465     THR J     2                                                      
REMARK 465     VAL J     3                                                      
REMARK 465     LEU J     4                                                      
REMARK 465     THR J   171                                                      
REMARK 465     SER J   172                                                      
REMARK 465     LEU J   173                                                      
REMARK 465     GLN J   174                                                      
REMARK 465     ASN J   175                                                      
REMARK 465     PHE J   176                                                      
REMARK 465     SER J   177                                                      
REMARK 465     ASN J   178                                                      
REMARK 465     CYS J   179                                                      
REMARK 465     LEU J   180                                                      
REMARK 465     PRO J   181                                                      
REMARK 465     ASN J   182                                                      
REMARK 465     SER J   183                                                      
REMARK 465     CYS J   184                                                      
REMARK 465     THR J   185                                                      
REMARK 465     THR J   186                                                      
REMARK 465     GLN J   187                                                      
REMARK 465     VAL J   188                                                      
REMARK 465     PRO J   189                                                      
REMARK 465     ASN J   190                                                      
REMARK 465     HIS J   191                                                      
REMARK 465     SER J   192                                                      
REMARK 465     LEU J   193                                                      
REMARK 465     SER J   194                                                      
REMARK 465     HIS J   195                                                      
REMARK 465     ARG J   196                                                      
REMARK 465     GLN J   197                                                      
REMARK 465     PRO J   198                                                      
REMARK 465     GLU J   199                                                      
REMARK 465     THR J   200                                                      
REMARK 465     VAL J   201                                                      
REMARK 465     LEU J   202                                                      
REMARK 465     THR J   203                                                      
REMARK 465     GLU J   204                                                      
REMARK 465     THR J   205                                                      
REMARK 465     PRO J   206                                                      
REMARK 465     GLN J   207                                                      
REMARK 465     ASP J   208                                                      
REMARK 465     THR J   209                                                      
REMARK 465     ILE J   210                                                      
REMARK 465     GLU J   211                                                      
REMARK 465     LEU J   212                                                      
REMARK 465     ASN J   213                                                      
REMARK 465     ARG J   214                                                      
REMARK 465     LEU J   215                                                      
REMARK 465     ASN J   216                                                      
REMARK 465     LEU J   217                                                      
REMARK 465     GLU J   218                                                      
REMARK 465     SER J   219                                                      
REMARK 465     SER J   220                                                      
REMARK 465     ASN J   221                                                      
REMARK 465     SER J   222                                                      
REMARK 465     LYS J   223                                                      
REMARK 465     TYR J   224                                                      
REMARK 465     SER J   225                                                      
REMARK 465     LEU J   226                                                      
REMARK 465     ASN J   227                                                      
REMARK 465     THR J   228                                                      
REMARK 465     ASP J   229                                                      
REMARK 465     SER J   230                                                      
REMARK 465     SER J   231                                                      
REMARK 465     VAL J   232                                                      
REMARK 465     SER J   233                                                      
REMARK 465     TYR J   234                                                      
REMARK 465     ILE J   235                                                      
REMARK 465     ASP J   236                                                      
REMARK 465     SER J   237                                                      
REMARK 465     ALA J   238                                                      
REMARK 465     VAL J   239                                                      
REMARK 465     ILE J   240                                                      
REMARK 465     SER J   241                                                      
REMARK 465     PRO J   242                                                      
REMARK 465     ASP J   243                                                      
REMARK 465     THR J   244                                                      
REMARK 465     VAL J   245                                                      
REMARK 465     PRO J   246                                                      
REMARK 465     LEU J   247                                                      
REMARK 465     GLY J   248                                                      
REMARK 465     THR J   249                                                      
REMARK 465     GLY J   250                                                      
REMARK 465     THR J   251                                                      
REMARK 465     SER J   252                                                      
REMARK 465     ILE J   253                                                      
REMARK 465     LEU J   254                                                      
REMARK 465     SER J   255                                                      
REMARK 465     LYS J   256                                                      
REMARK 465     GLN J   257                                                      
REMARK 465     VAL J   258                                                      
REMARK 465     GLN J   259                                                      
REMARK 465     ASN J   260                                                      
REMARK 465     LYS J   261                                                      
REMARK 465     PRO J   262                                                      
REMARK 465     LYS J   263                                                      
REMARK 465     THR J   264                                                      
REMARK 465     GLY J   265                                                      
REMARK 465     ARG J   266                                                      
REMARK 465     SER J   267                                                      
REMARK 465     LEU J   268                                                      
REMARK 465     LEU J   269                                                      
REMARK 465     GLY J   270                                                      
REMARK 465     GLY J   271                                                      
REMARK 465     PRO J   272                                                      
REMARK 465     ALA J   273                                                      
REMARK 465     ALA J   274                                                      
REMARK 465     LEU J   275                                                      
REMARK 465     SER J   276                                                      
REMARK 465     PRO J   277                                                      
REMARK 465     LEU J   278                                                      
REMARK 465     THR J   279                                                      
REMARK 465     PRO J   280                                                      
REMARK 465     SER J   281                                                      
REMARK 465     PHE J   282                                                      
REMARK 465     GLY J   283                                                      
REMARK 465     ILE J   284                                                      
REMARK 465     LEU J   285                                                      
REMARK 465     PRO J   286                                                      
REMARK 465     LEU J   287                                                      
REMARK 465     GLU J   288                                                      
REMARK 465     THR J   289                                                      
REMARK 465     PRO J   290                                                      
REMARK 465     SER J   291                                                      
REMARK 465     PRO J   292                                                      
REMARK 465     GLY J   293                                                      
REMARK 465     ASP J   294                                                      
REMARK 465     GLY J   295                                                      
REMARK 465     SER J   296                                                      
REMARK 465     TYR J   297                                                      
REMARK 465     LEU J   298                                                      
REMARK 465     GLN J   299                                                      
REMARK 465     ASN J   300                                                      
REMARK 465     TYR J   301                                                      
REMARK 465     THR J   302                                                      
REMARK 465     ASN J   303                                                      
REMARK 465     THR J   304                                                      
REMARK 465     PRO J   305                                                      
REMARK 465     PRO J   306                                                      
REMARK 465     VAL J   307                                                      
REMARK 465     ILE J   308                                                      
REMARK 465     ASP J   309                                                      
REMARK 465     VAL J   310                                                      
REMARK 465     PRO J   311                                                      
REMARK 465     SER J   312                                                      
REMARK 465     THR J   313                                                      
REMARK 465     GLY J   314                                                      
REMARK 465     ALA J   315                                                      
REMARK 465     PRO J   316                                                      
REMARK 465     SER J   317                                                      
REMARK 465     LYS J   318                                                      
REMARK 465     LYS J   319                                                      
REMARK 465     SER J   320                                                      
REMARK 465     VAL J   321                                                      
REMARK 465     ALA J   322                                                      
REMARK 465     ARG J   323                                                      
REMARK 465     ILE J   324                                                      
REMARK 465     GLY J   325                                                      
REMARK 465     GLN J   326                                                      
REMARK 465     THR J   327                                                      
REMARK 465     GLY J   328                                                      
REMARK 465     THR J   329                                                      
REMARK 465     LYS J   330                                                      
REMARK 465     SER J   331                                                      
REMARK 465     VAL J   332                                                      
REMARK 465     PHE J   333                                                      
REMARK 465     SER J   334                                                      
REMARK 465     GLN J   335                                                      
REMARK 465     SER J   336                                                      
REMARK 465     GLY J   337                                                      
REMARK 465     ASN J   338                                                      
REMARK 465     SER J   339                                                      
REMARK 465     ARG J   340                                                      
REMARK 465     GLU J   341                                                      
REMARK 465     VAL J   342                                                      
REMARK 465     THR J   343                                                      
REMARK 465     PRO J   344                                                      
REMARK 465     ILE J   345                                                      
REMARK 465     LEU J   346                                                      
REMARK 465     ALA J   347                                                      
REMARK 465     GLN J   348                                                      
REMARK 465     THR J   349                                                      
REMARK 465     GLN J   350                                                      
REMARK 465     SER J   351                                                      
REMARK 465     SER J   352                                                      
REMARK 465     GLY J   353                                                      
REMARK 465     PRO J   354                                                      
REMARK 465     GLN J   355                                                      
REMARK 465     THR J   356                                                      
REMARK 465     SER J   357                                                      
REMARK 465     THR J   358                                                      
REMARK 465     THR J   359                                                      
REMARK 465     PRO J   360                                                      
REMARK 465     GLN J   361                                                      
REMARK 465     VAL J   362                                                      
REMARK 465     LEU J   363                                                      
REMARK 465     SER J   364                                                      
REMARK 465     PRO J   365                                                      
REMARK 465     THR J   366                                                      
REMARK 465     ILE J   367                                                      
REMARK 465     THR J   368                                                      
REMARK 465     SER J   369                                                      
REMARK 465     PRO J   370                                                      
REMARK 465     PRO J   371                                                      
REMARK 465     ASN J   372                                                      
REMARK 465     ALA J   373                                                      
REMARK 465     LEU J   374                                                      
REMARK 465     PRO J   375                                                      
REMARK 465     ARG J   376                                                      
REMARK 465     ARG J   377                                                      
REMARK 465     SER J   378                                                      
REMARK 465     SER J   379                                                      
REMARK 465     ARG J   380                                                      
REMARK 465     LEU J   381                                                      
REMARK 465     PHE J   382                                                      
REMARK 465     THR J   383                                                      
REMARK 465     SER J   384                                                      
REMARK 465     ASP J   385                                                      
REMARK 465     SER J   386                                                      
REMARK 465     SER J   387                                                      
REMARK 465     THR J   388                                                      
REMARK 465     THR J   389                                                      
REMARK 465     LYS J   390                                                      
REMARK 465     GLU J   391                                                      
REMARK 465     ASN J   392                                                      
REMARK 465     SER J   393                                                      
REMARK 465     LYS J   394                                                      
REMARK 465     LYS J   395                                                      
REMARK 465     LEU J   396                                                      
REMARK 465     LYS J   397                                                      
REMARK 465     MET J   398                                                      
REMARK 465     LYS J   399                                                      
REMARK 465     PHE J   400                                                      
REMARK 465     PRO J   401                                                      
REMARK 465     PRO J   402                                                      
REMARK 465     LYS J   403                                                      
REMARK 465     ILE J   404                                                      
REMARK 465     PRO J   405                                                      
REMARK 465     ASN J   406                                                      
REMARK 465     ARG J   407                                                      
REMARK 465     LYS J   408                                                      
REMARK 465     THR J   409                                                      
REMARK 465     LYS J   410                                                      
REMARK 465     SER J   411                                                      
REMARK 465     LYS J   412                                                      
REMARK 465     THR J   413                                                      
REMARK 465     ASN J   414                                                      
REMARK 465     LYS J   415                                                      
REMARK 465     GLY J   416                                                      
REMARK 465     GLY J   417                                                      
REMARK 465     ILE J   418                                                      
REMARK 465     THR J   419                                                      
REMARK 465     GLN J   420                                                      
REMARK 465     PRO J   421                                                      
REMARK 465     ASN J   422                                                      
REMARK 465     ILE J   423                                                      
REMARK 465     ASN J   424                                                      
REMARK 465     ASP J   425                                                      
REMARK 465     SER J   426                                                      
REMARK 465     LEU J   427                                                      
REMARK 465     GLU J   428                                                      
REMARK 465     ILE J   429                                                      
REMARK 465     THR J   430                                                      
REMARK 465     LYS J   431                                                      
REMARK 465     LEU J   432                                                      
REMARK 465     ASP J   433                                                      
REMARK 465     SER J   434                                                      
REMARK 465     SER J   435                                                      
REMARK 465     ILE J   436                                                      
REMARK 465     ILE J   437                                                      
REMARK 465     SER J   438                                                      
REMARK 465     GLU J   439                                                      
REMARK 465     GLY J   440                                                      
REMARK 465     LYS J   441                                                      
REMARK 465     ILE J   442                                                      
REMARK 465     SER J   443                                                      
REMARK 465     THR J   444                                                      
REMARK 465     ILE J   445                                                      
REMARK 465     THR J   446                                                      
REMARK 465     PRO J   447                                                      
REMARK 465     GLN J   448                                                      
REMARK 465     ILE J   449                                                      
REMARK 465     GLN J   450                                                      
REMARK 465     LYS J   781                                                      
REMARK 465     ARG J   782                                                      
REMARK 465     TYR J   783                                                      
REMARK 465     LEU J   784                                                      
REMARK 465     PRO J   785                                                      
REMARK 465     ASP J   786                                                      
REMARK 465     ASP J   787                                                      
REMARK 465     GLU J   788                                                      
REMARK 465     GLU J   789                                                      
REMARK 465     PRO J   790                                                      
REMARK 465     ILE J   791                                                      
REMARK 465     THR J   792                                                      
REMARK 465     GLN J   793                                                      
REMARK 465     GLU J   794                                                      
REMARK 465     GLU J   795                                                      
REMARK 465     GLN J   796                                                      
REMARK 465     ILE J   797                                                      
REMARK 465     MET J   798                                                      
REMARK 465     GLY J   799                                                      
REMARK 465     THR J   800                                                      
REMARK 465     ASP J   801                                                      
REMARK 465     GLU J   802                                                      
REMARK 465     SER J   803                                                      
REMARK 465     GLN J   804                                                      
REMARK 465     GLU J   805                                                      
REMARK 465     SER J   806                                                      
REMARK 465     SER J   807                                                      
REMARK 465     MET J   808                                                      
REMARK 465     THR J   809                                                      
REMARK 465     ASP J   810                                                      
REMARK 465     ALA J   811                                                      
REMARK 465     ASP J   812                                                      
REMARK 465     ASP J   813                                                      
REMARK 465     THR J   814                                                      
REMARK 465     GLN J   815                                                      
REMARK 465     LEU J   816                                                      
REMARK 465     HIS J   817                                                      
REMARK 465     ALA J   818                                                      
REMARK 465     ALA J   819                                                      
REMARK 465     GLU J   820                                                      
REMARK 465     SER J   821                                                      
REMARK 465     ASP J   822                                                      
REMARK 465     GLU J   823                                                      
REMARK 465     PHE J   824                                                      
REMARK 465     MET P     1                                                      
REMARK 465     THR P     2                                                      
REMARK 465     VAL P     3                                                      
REMARK 465     LEU P     4                                                      
REMARK 465     SER P   172                                                      
REMARK 465     LEU P   173                                                      
REMARK 465     GLN P   174                                                      
REMARK 465     ASN P   175                                                      
REMARK 465     PHE P   176                                                      
REMARK 465     SER P   177                                                      
REMARK 465     ASN P   178                                                      
REMARK 465     CYS P   179                                                      
REMARK 465     LEU P   180                                                      
REMARK 465     PRO P   181                                                      
REMARK 465     ASN P   182                                                      
REMARK 465     SER P   183                                                      
REMARK 465     CYS P   184                                                      
REMARK 465     THR P   185                                                      
REMARK 465     THR P   186                                                      
REMARK 465     GLN P   187                                                      
REMARK 465     VAL P   188                                                      
REMARK 465     PRO P   189                                                      
REMARK 465     ASN P   190                                                      
REMARK 465     HIS P   191                                                      
REMARK 465     SER P   192                                                      
REMARK 465     LEU P   193                                                      
REMARK 465     SER P   194                                                      
REMARK 465     HIS P   195                                                      
REMARK 465     ARG P   196                                                      
REMARK 465     GLN P   197                                                      
REMARK 465     PRO P   198                                                      
REMARK 465     GLU P   199                                                      
REMARK 465     THR P   200                                                      
REMARK 465     VAL P   201                                                      
REMARK 465     LEU P   202                                                      
REMARK 465     THR P   203                                                      
REMARK 465     GLU P   204                                                      
REMARK 465     THR P   205                                                      
REMARK 465     PRO P   206                                                      
REMARK 465     GLN P   207                                                      
REMARK 465     ASP P   208                                                      
REMARK 465     THR P   209                                                      
REMARK 465     ILE P   210                                                      
REMARK 465     GLU P   211                                                      
REMARK 465     LEU P   212                                                      
REMARK 465     ASN P   213                                                      
REMARK 465     ARG P   214                                                      
REMARK 465     LEU P   215                                                      
REMARK 465     ASN P   216                                                      
REMARK 465     LEU P   217                                                      
REMARK 465     GLU P   218                                                      
REMARK 465     SER P   219                                                      
REMARK 465     SER P   220                                                      
REMARK 465     ASN P   221                                                      
REMARK 465     SER P   222                                                      
REMARK 465     LYS P   223                                                      
REMARK 465     TYR P   224                                                      
REMARK 465     SER P   225                                                      
REMARK 465     LEU P   226                                                      
REMARK 465     ASN P   227                                                      
REMARK 465     THR P   228                                                      
REMARK 465     ASP P   229                                                      
REMARK 465     SER P   230                                                      
REMARK 465     SER P   231                                                      
REMARK 465     VAL P   232                                                      
REMARK 465     SER P   233                                                      
REMARK 465     TYR P   234                                                      
REMARK 465     ILE P   235                                                      
REMARK 465     ASP P   236                                                      
REMARK 465     SER P   237                                                      
REMARK 465     ALA P   238                                                      
REMARK 465     VAL P   239                                                      
REMARK 465     ILE P   240                                                      
REMARK 465     SER P   241                                                      
REMARK 465     PRO P   242                                                      
REMARK 465     ASP P   243                                                      
REMARK 465     THR P   244                                                      
REMARK 465     VAL P   245                                                      
REMARK 465     PRO P   246                                                      
REMARK 465     LEU P   247                                                      
REMARK 465     GLY P   248                                                      
REMARK 465     THR P   249                                                      
REMARK 465     GLY P   250                                                      
REMARK 465     THR P   251                                                      
REMARK 465     SER P   252                                                      
REMARK 465     ILE P   253                                                      
REMARK 465     LEU P   254                                                      
REMARK 465     SER P   255                                                      
REMARK 465     LYS P   256                                                      
REMARK 465     GLN P   257                                                      
REMARK 465     VAL P   258                                                      
REMARK 465     GLN P   259                                                      
REMARK 465     ASN P   260                                                      
REMARK 465     LYS P   261                                                      
REMARK 465     PRO P   262                                                      
REMARK 465     LYS P   263                                                      
REMARK 465     THR P   264                                                      
REMARK 465     GLY P   265                                                      
REMARK 465     ARG P   266                                                      
REMARK 465     SER P   267                                                      
REMARK 465     LEU P   268                                                      
REMARK 465     LEU P   269                                                      
REMARK 465     GLY P   270                                                      
REMARK 465     GLY P   271                                                      
REMARK 465     PRO P   272                                                      
REMARK 465     ALA P   273                                                      
REMARK 465     ALA P   274                                                      
REMARK 465     LEU P   275                                                      
REMARK 465     SER P   276                                                      
REMARK 465     PRO P   277                                                      
REMARK 465     LEU P   278                                                      
REMARK 465     THR P   279                                                      
REMARK 465     PRO P   280                                                      
REMARK 465     SER P   281                                                      
REMARK 465     PHE P   282                                                      
REMARK 465     GLY P   283                                                      
REMARK 465     ILE P   284                                                      
REMARK 465     LEU P   285                                                      
REMARK 465     PRO P   286                                                      
REMARK 465     LEU P   287                                                      
REMARK 465     GLU P   288                                                      
REMARK 465     THR P   289                                                      
REMARK 465     PRO P   290                                                      
REMARK 465     SER P   291                                                      
REMARK 465     PRO P   292                                                      
REMARK 465     GLY P   293                                                      
REMARK 465     ASP P   294                                                      
REMARK 465     GLY P   295                                                      
REMARK 465     SER P   296                                                      
REMARK 465     TYR P   297                                                      
REMARK 465     LEU P   298                                                      
REMARK 465     GLN P   299                                                      
REMARK 465     ASN P   300                                                      
REMARK 465     TYR P   301                                                      
REMARK 465     THR P   302                                                      
REMARK 465     ASN P   303                                                      
REMARK 465     THR P   304                                                      
REMARK 465     PRO P   305                                                      
REMARK 465     PRO P   306                                                      
REMARK 465     VAL P   307                                                      
REMARK 465     ILE P   308                                                      
REMARK 465     ASP P   309                                                      
REMARK 465     VAL P   310                                                      
REMARK 465     PRO P   311                                                      
REMARK 465     SER P   312                                                      
REMARK 465     THR P   313                                                      
REMARK 465     GLY P   314                                                      
REMARK 465     ALA P   315                                                      
REMARK 465     PRO P   316                                                      
REMARK 465     SER P   317                                                      
REMARK 465     LYS P   318                                                      
REMARK 465     LYS P   319                                                      
REMARK 465     SER P   320                                                      
REMARK 465     VAL P   321                                                      
REMARK 465     ALA P   322                                                      
REMARK 465     ARG P   323                                                      
REMARK 465     ILE P   324                                                      
REMARK 465     GLY P   325                                                      
REMARK 465     GLN P   326                                                      
REMARK 465     THR P   327                                                      
REMARK 465     GLY P   328                                                      
REMARK 465     THR P   329                                                      
REMARK 465     LYS P   330                                                      
REMARK 465     SER P   331                                                      
REMARK 465     VAL P   332                                                      
REMARK 465     PHE P   333                                                      
REMARK 465     SER P   334                                                      
REMARK 465     GLN P   335                                                      
REMARK 465     SER P   336                                                      
REMARK 465     GLY P   337                                                      
REMARK 465     ASN P   338                                                      
REMARK 465     SER P   339                                                      
REMARK 465     ARG P   340                                                      
REMARK 465     GLU P   341                                                      
REMARK 465     VAL P   342                                                      
REMARK 465     THR P   343                                                      
REMARK 465     PRO P   344                                                      
REMARK 465     ILE P   345                                                      
REMARK 465     LEU P   346                                                      
REMARK 465     ALA P   347                                                      
REMARK 465     GLN P   348                                                      
REMARK 465     THR P   349                                                      
REMARK 465     GLN P   350                                                      
REMARK 465     SER P   351                                                      
REMARK 465     SER P   352                                                      
REMARK 465     GLY P   353                                                      
REMARK 465     PRO P   354                                                      
REMARK 465     GLN P   355                                                      
REMARK 465     THR P   356                                                      
REMARK 465     SER P   357                                                      
REMARK 465     THR P   358                                                      
REMARK 465     THR P   359                                                      
REMARK 465     PRO P   360                                                      
REMARK 465     GLN P   361                                                      
REMARK 465     VAL P   362                                                      
REMARK 465     LEU P   363                                                      
REMARK 465     SER P   364                                                      
REMARK 465     PRO P   365                                                      
REMARK 465     THR P   366                                                      
REMARK 465     ILE P   367                                                      
REMARK 465     THR P   368                                                      
REMARK 465     SER P   369                                                      
REMARK 465     PRO P   370                                                      
REMARK 465     PRO P   371                                                      
REMARK 465     ASN P   372                                                      
REMARK 465     ALA P   373                                                      
REMARK 465     LEU P   374                                                      
REMARK 465     PRO P   375                                                      
REMARK 465     ARG P   376                                                      
REMARK 465     ARG P   377                                                      
REMARK 465     SER P   378                                                      
REMARK 465     SER P   379                                                      
REMARK 465     ARG P   380                                                      
REMARK 465     LEU P   381                                                      
REMARK 465     PHE P   382                                                      
REMARK 465     THR P   383                                                      
REMARK 465     SER P   384                                                      
REMARK 465     ASP P   385                                                      
REMARK 465     SER P   386                                                      
REMARK 465     SER P   387                                                      
REMARK 465     THR P   388                                                      
REMARK 465     THR P   389                                                      
REMARK 465     LYS P   390                                                      
REMARK 465     GLU P   391                                                      
REMARK 465     ASN P   392                                                      
REMARK 465     SER P   393                                                      
REMARK 465     LYS P   394                                                      
REMARK 465     LYS P   395                                                      
REMARK 465     LEU P   396                                                      
REMARK 465     LYS P   397                                                      
REMARK 465     MET P   398                                                      
REMARK 465     LYS P   399                                                      
REMARK 465     PHE P   400                                                      
REMARK 465     PRO P   401                                                      
REMARK 465     PRO P   402                                                      
REMARK 465     LYS P   403                                                      
REMARK 465     ILE P   404                                                      
REMARK 465     PRO P   405                                                      
REMARK 465     ASN P   406                                                      
REMARK 465     ARG P   407                                                      
REMARK 465     LYS P   408                                                      
REMARK 465     THR P   409                                                      
REMARK 465     LYS P   410                                                      
REMARK 465     SER P   411                                                      
REMARK 465     LYS P   412                                                      
REMARK 465     THR P   413                                                      
REMARK 465     ASN P   414                                                      
REMARK 465     LYS P   415                                                      
REMARK 465     GLY P   416                                                      
REMARK 465     GLY P   417                                                      
REMARK 465     ILE P   418                                                      
REMARK 465     THR P   419                                                      
REMARK 465     GLN P   420                                                      
REMARK 465     PRO P   421                                                      
REMARK 465     ASN P   422                                                      
REMARK 465     ILE P   423                                                      
REMARK 465     ASN P   424                                                      
REMARK 465     ASP P   425                                                      
REMARK 465     SER P   426                                                      
REMARK 465     LEU P   427                                                      
REMARK 465     GLU P   428                                                      
REMARK 465     ILE P   429                                                      
REMARK 465     THR P   430                                                      
REMARK 465     LYS P   431                                                      
REMARK 465     LEU P   432                                                      
REMARK 465     ASP P   433                                                      
REMARK 465     SER P   434                                                      
REMARK 465     SER P   435                                                      
REMARK 465     ILE P   436                                                      
REMARK 465     ILE P   437                                                      
REMARK 465     SER P   438                                                      
REMARK 465     GLU P   439                                                      
REMARK 465     GLY P   440                                                      
REMARK 465     LYS P   441                                                      
REMARK 465     ILE P   442                                                      
REMARK 465     SER P   443                                                      
REMARK 465     THR P   444                                                      
REMARK 465     ILE P   445                                                      
REMARK 465     THR P   446                                                      
REMARK 465     PRO P   447                                                      
REMARK 465     GLN P   448                                                      
REMARK 465     ILE P   449                                                      
REMARK 465     GLN P   450                                                      
REMARK 465     ALA P   451                                                      
REMARK 465     LYS P   769                                                      
REMARK 465     GLY P   770                                                      
REMARK 465     ALA P   771                                                      
REMARK 465     ASN P   772                                                      
REMARK 465     ASN P   773                                                      
REMARK 465     GLN P   774                                                      
REMARK 465     ILE P   775                                                      
REMARK 465     LYS P   776                                                      
REMARK 465     GLU P   777                                                      
REMARK 465     ALA P   778                                                      
REMARK 465     ILE P   779                                                      
REMARK 465     ASP P   780                                                      
REMARK 465     LYS P   781                                                      
REMARK 465     ARG P   782                                                      
REMARK 465     TYR P   783                                                      
REMARK 465     LEU P   784                                                      
REMARK 465     PRO P   785                                                      
REMARK 465     ASP P   786                                                      
REMARK 465     ASP P   787                                                      
REMARK 465     GLU P   788                                                      
REMARK 465     GLU P   789                                                      
REMARK 465     PRO P   790                                                      
REMARK 465     ILE P   791                                                      
REMARK 465     THR P   792                                                      
REMARK 465     GLN P   793                                                      
REMARK 465     GLU P   794                                                      
REMARK 465     GLU P   795                                                      
REMARK 465     GLN P   796                                                      
REMARK 465     ILE P   797                                                      
REMARK 465     MET P   798                                                      
REMARK 465     GLY P   799                                                      
REMARK 465     THR P   800                                                      
REMARK 465     ASP P   801                                                      
REMARK 465     GLU P   802                                                      
REMARK 465     SER P   803                                                      
REMARK 465     GLN P   804                                                      
REMARK 465     GLU P   805                                                      
REMARK 465     SER P   806                                                      
REMARK 465     SER P   807                                                      
REMARK 465     MET P   808                                                      
REMARK 465     THR P   809                                                      
REMARK 465     ASP P   810                                                      
REMARK 465     ALA P   811                                                      
REMARK 465     ASP P   812                                                      
REMARK 465     ASP P   813                                                      
REMARK 465     THR P   814                                                      
REMARK 465     GLN P   815                                                      
REMARK 465     LEU P   816                                                      
REMARK 465     HIS P   817                                                      
REMARK 465     ALA P   818                                                      
REMARK 465     ALA P   819                                                      
REMARK 465     GLU P   820                                                      
REMARK 465     SER P   821                                                      
REMARK 465     ASP P   822                                                      
REMARK 465     GLU P   823                                                      
REMARK 465     PHE P   824                                                      
REMARK 465     MET Q     1                                                      
REMARK 465     GLU Q    96                                                      
REMARK 465     GLU Q    97                                                      
REMARK 465     PRO Q    98                                                      
REMARK 465     ILE Q    99                                                      
REMARK 465     ASN Q   100                                                      
REMARK 465     LYS Q   101                                                      
REMARK 465     ARG Q   102                                                      
REMARK 465     LEU Q   103                                                      
REMARK 465     PHE Q   104                                                      
REMARK 465     GLU Q   105                                                      
REMARK 465     LYS Q   106                                                      
REMARK 465     TYR Q   107                                                      
REMARK 465     LEU Q   108                                                      
REMARK 465     LYS Q   109                                                      
REMARK 465     ASP Q   110                                                      
REMARK 465     GLU Q   111                                                      
REMARK 465     SER Q   112                                                      
REMARK 465     GLY Q   113                                                      
REMARK 465     PHE Q   114                                                      
REMARK 465     LYS Q   115                                                      
REMARK 465     ASP Q   116                                                      
REMARK 465     PRO Q   117                                                      
REMARK 465     SER Q   118                                                      
REMARK 465     SER Q   119                                                      
REMARK 465     ASP Q   120                                                      
REMARK 465     TRP Q   121                                                      
REMARK 465     GLU Q   122                                                      
REMARK 465     MET Q   123                                                      
REMARK 465     ILE Q   534                                                      
REMARK 465     GLY Q   535                                                      
REMARK 465     ALA Q   536                                                      
REMARK 465     ASP Q   537                                                      
REMARK 465     ILE Q   538                                                      
REMARK 465     LYS Q   539                                                      
REMARK 465     ASP Q   540                                                      
REMARK 465     LYS Q   541                                                      
REMARK 465     LEU Q   542                                                      
REMARK 465     LYS Q   543                                                      
REMARK 465     CYS Q   544                                                      
REMARK 465     TYR Q   545                                                      
REMARK 465     ASP Q   546                                                      
REMARK 465     PHE Q   547                                                      
REMARK 465     ASP Q   548                                                      
REMARK 465     VAL Q   549                                                      
REMARK 465     HIS Q   550                                                      
REMARK 465     THR Q   551                                                      
REMARK 465     MET Q   552                                                      
REMARK 465     LYS Q   553                                                      
REMARK 465     THR Q   554                                                      
REMARK 465     LEU Q   555                                                      
REMARK 465     LYS Q   556                                                      
REMARK 465     ASN Q   557                                                      
REMARK 465     ILE Q   558                                                      
REMARK 465     ILE Q   559                                                      
REMARK 465     SER Q   560                                                      
REMARK 465     PRO Q   561                                                      
REMARK 465     PRO Q   562                                                      
REMARK 465     TRP Q   563                                                      
REMARK 465     ASP Q   564                                                      
REMARK 465     PHE Q   565                                                      
REMARK 465     ARG Q   566                                                      
REMARK 465     GLU Q   567                                                      
REMARK 465     PHE Q   568                                                      
REMARK 465     GLU Q   569                                                      
REMARK 465     VAL Q   570                                                      
REMARK 465     GLU Q   571                                                      
REMARK 465     LYS Q   572                                                      
REMARK 465     GLN Q   573                                                      
REMARK 465     THR Q   574                                                      
REMARK 465     ALA Q   575                                                      
REMARK 465     GLU Q   576                                                      
REMARK 465     GLU Q   577                                                      
REMARK 465     THR Q   578                                                      
REMARK 465     GLY Q   579                                                      
REMARK 465     LEU Q   580                                                      
REMARK 465     THR Q   581                                                      
REMARK 465     PRO Q   582                                                      
REMARK 465     LEU Q   583                                                      
REMARK 465     GLU Q   584                                                      
REMARK 465     THR Q   585                                                      
REMARK 465     SER Q   586                                                      
REMARK 465     ARG Q   587                                                      
REMARK 465     LYS Q   588                                                      
REMARK 465     THR Q   589                                                      
REMARK 465     PRO Q   590                                                      
REMARK 465     ASP Q   591                                                      
REMARK 465     SER Q   592                                                      
REMARK 465     ARG Q   593                                                      
REMARK 465     PRO Q   594                                                      
REMARK 465     SER Q   595                                                      
REMARK 465     LEU Q   596                                                      
REMARK 465     GLU Q   597                                                      
REMARK 465     GLU Q   598                                                      
REMARK 465     THR Q   599                                                      
REMARK 465     PHE Q   600                                                      
REMARK 465     GLU Q   601                                                      
REMARK 465     ILE Q   602                                                      
REMARK 465     GLU Q   603                                                      
REMARK 465     MET Q   604                                                      
REMARK 465     ASN Q   605                                                      
REMARK 465     GLU Q   606                                                      
REMARK 465     SER Q   607                                                      
REMARK 465     ASP Q   608                                                      
REMARK 465     MET Q   609                                                      
REMARK 465     MET Q   610                                                      
REMARK 465     LEU Q   611                                                      
REMARK 465     GLU Q   612                                                      
REMARK 465     THR Q   613                                                      
REMARK 465     SER Q   614                                                      
REMARK 465     MET Q   615                                                      
REMARK 465     SER Q   616                                                      
REMARK 465     ASP Q   617                                                      
REMARK 465     HIS Q   618                                                      
REMARK 465     SER Q   619                                                      
REMARK 465     THR Q   620                                                      
REMARK 465     MET Y     1                                                      
REMARK 465     ASP Y     2                                                      
REMARK 465     PRO Y     3                                                      
REMARK 465     GLY Y     4                                                      
REMARK 465     ASP Y     5                                                      
REMARK 465     ALA Y     6                                                      
REMARK 465     ALA Y     7                                                      
REMARK 465     ILE Y     8                                                      
REMARK 465     LEU Y     9                                                      
REMARK 465     GLU Y    10                                                      
REMARK 465     SER Y    11                                                      
REMARK 465     SER Y    12                                                      
REMARK 465     LEU Y    13                                                      
REMARK 465     ARG Y    14                                                      
REMARK 465     ILE Y    15                                                      
REMARK 465     LEU Y    16                                                      
REMARK 465     TYR Y    17                                                      
REMARK 465     ARG Y    18                                                      
REMARK 465     LEU Y    19                                                      
REMARK 465     PHE Y    20                                                      
REMARK 465     GLU Y    21                                                      
REMARK 465     SER Y    22                                                      
REMARK 465     VAL Y    23                                                      
REMARK 465     LEU Y    24                                                      
REMARK 465     PRO Y    25                                                      
REMARK 465     PRO Y    26                                                      
REMARK 465     LEU Y    27                                                      
REMARK 465     PRO Y    28                                                      
REMARK 465     ALA Y    29                                                      
REMARK 465     ALA Y    30                                                      
REMARK 465     LEU Y    31                                                      
REMARK 465     GLN Y    32                                                      
REMARK 465     SER Y    33                                                      
REMARK 465     ARG Y    34                                                      
REMARK 465     MET Y    35                                                      
REMARK 465     SER Y   111                                                      
REMARK 465     LYS Y   112                                                      
REMARK 465     THR Y   113                                                      
REMARK 465     SER Y   114                                                      
REMARK 465     LYS Y   115                                                      
REMARK 465     VAL Y   116                                                      
REMARK 465     ARG Y   117                                                      
REMARK 465     PRO Y   118                                                      
REMARK 465     SER Y   119                                                      
REMARK 465     THR Y   120                                                      
REMARK 465     GLY Y   121                                                      
REMARK 465     ASN Y   122                                                      
REMARK 465     SER Y   123                                                      
REMARK 465     ALA Y   124                                                      
REMARK 465     SER Y   125                                                      
REMARK 465     THR Y   126                                                      
REMARK 465     PRO Y   127                                                      
REMARK 465     GLN Y   128                                                      
REMARK 465     SER Y   129                                                      
REMARK 465     GLN Y   130                                                      
REMARK 465     CYS Y   131                                                      
REMARK 465     GLU Y   556                                                      
REMARK 465     SER Y   557                                                      
REMARK 465     PRO Y   558                                                      
REMARK 465     THR Y   559                                                      
REMARK 465     ASP Y   560                                                      
REMARK 465     ALA Y   561                                                      
REMARK 465     THR Y   562                                                      
REMARK 465     GLN Y   563                                                      
REMARK 465     GLU Y   564                                                      
REMARK 465     GLU Y   565                                                      
REMARK 465     ASP Y   566                                                      
REMARK 465     VAL Y   567                                                      
REMARK 465     ASP Y   568                                                      
REMARK 465     ASP Y   569                                                      
REMARK 465     MET Y   570                                                      
REMARK 465     GLU Y   571                                                      
REMARK 465     GLY Y   572                                                      
REMARK 465     SER Y   573                                                      
REMARK 465     GLY Y   574                                                      
REMARK 465     GLU Y   575                                                      
REMARK 465     GLU Y   576                                                      
REMARK 465     GLY Y   577                                                      
REMARK 465     ASP Y   578                                                      
REMARK 465     LEU Y   579                                                      
REMARK 465     GLU Y   580                                                      
REMARK 465     GLY Y   581                                                      
REMARK 465     SER Y   582                                                      
REMARK 465     ASP Y   583                                                      
REMARK 465     SER Y   584                                                      
REMARK 465     GLU Y   585                                                      
REMARK 465     ALA Y   586                                                      
REMARK 465     ALA Y   587                                                      
REMARK 465     GLN Y   588                                                      
REMARK 465     TRP Y   589                                                      
REMARK 465     ALA Y   590                                                      
REMARK 465     ASP Y   591                                                      
REMARK 465     GLN Y   592                                                      
REMARK 465     GLU Y   593                                                      
REMARK 465     GLN Y   594                                                      
REMARK 465     TRP Y   595                                                      
REMARK 465     PHE Y   596                                                      
REMARK 465     GLY Y   597                                                      
REMARK 465     MET Y   598                                                      
REMARK 465     GLN Y   599                                                      
REMARK 465     MET U     1                                                      
REMARK 465     ALA U     2                                                      
REMARK 465     ALA U     3                                                      
REMARK 465     SER U     4                                                      
REMARK 465     THR U     5                                                      
REMARK 465     SER U     6                                                      
REMARK 465     MET U     7                                                      
REMARK 465     VAL U     8                                                      
REMARK 465     PRO U     9                                                      
REMARK 465     VAL U    10                                                      
REMARK 465     ALA U    11                                                      
REMARK 465     VAL U    12                                                      
REMARK 465     THR U    13                                                      
REMARK 465     ALA U    14                                                      
REMARK 465     ALA U    15                                                      
REMARK 465     VAL U    16                                                      
REMARK 465     ALA U    17                                                      
REMARK 465     PRO U    18                                                      
REMARK 465     VAL U    19                                                      
REMARK 465     LEU U    20                                                      
REMARK 465     SER U    21                                                      
REMARK 465     ILE U    22                                                      
REMARK 465     ASN U    23                                                      
REMARK 465     SER U    24                                                      
REMARK 465     ASP U    25                                                      
REMARK 465     VAL U   135                                                      
REMARK 465     ASP U   136                                                      
REMARK 465     SER U   137                                                      
REMARK 465     LEU U   138                                                      
REMARK 465     GLY U   139                                                      
REMARK 465     PRO U   140                                                      
REMARK 465     LEU U   141                                                      
REMARK 465     GLU U   142                                                      
REMARK 465     LYS U   143                                                      
REMARK 465     GLY U   144                                                      
REMARK 465     GLN U   145                                                      
REMARK 465     GLU U   502                                                      
REMARK 465     ILE U   503                                                      
REMARK 465     VAL U   504                                                      
REMARK 465     GLN U   555                                                      
REMARK 465     LEU U   556                                                      
REMARK 465     ARG U   557                                                      
REMARK 465     ASN U   558                                                      
REMARK 465     GLN U   559                                                      
REMARK 465     GLY U   560                                                      
REMARK 465     GLU U   561                                                      
REMARK 465     THR U   562                                                      
REMARK 465     PRO U   563                                                      
REMARK 465     THR U   564                                                      
REMARK 465     THR U   565                                                      
REMARK 465     GLU U   566                                                      
REMARK 465     VAL U   567                                                      
REMARK 465     PRO U   568                                                      
REMARK 465     ALA U   569                                                      
REMARK 465     PRO U   570                                                      
REMARK 465     PHE U   571                                                      
REMARK 465     PHE U   572                                                      
REMARK 465     LEU U   573                                                      
REMARK 465     PRO U   574                                                      
REMARK 465     ALA U   575                                                      
REMARK 465     SER U   576                                                      
REMARK 465     LEU U   577                                                      
REMARK 465     SER U   578                                                      
REMARK 465     ALA U   579                                                      
REMARK 465     ASN U   580                                                      
REMARK 465     ASN U   581                                                      
REMARK 465     THR U   582                                                      
REMARK 465     PRO U   583                                                      
REMARK 465     THR U   584                                                      
REMARK 465     ARG U   585                                                      
REMARK 465     ARG U   586                                                      
REMARK 465     VAL U   587                                                      
REMARK 465     SER U   588                                                      
REMARK 465     PRO U   589                                                      
REMARK 465     LEU U   590                                                      
REMARK 465     ASN U   591                                                      
REMARK 465     LEU U   592                                                      
REMARK 465     SER U   593                                                      
REMARK 465     SER U   594                                                      
REMARK 465     VAL U   595                                                      
REMARK 465     THR U   596                                                      
REMARK 465     PRO U   597                                                      
REMARK 465     MET V     1                                                      
REMARK 465     ALA V     2                                                      
REMARK 465     ALA V     3                                                      
REMARK 465     SER V     4                                                      
REMARK 465     THR V     5                                                      
REMARK 465     SER V     6                                                      
REMARK 465     MET V     7                                                      
REMARK 465     VAL V     8                                                      
REMARK 465     PRO V     9                                                      
REMARK 465     VAL V    10                                                      
REMARK 465     ALA V    11                                                      
REMARK 465     VAL V    12                                                      
REMARK 465     THR V    13                                                      
REMARK 465     ALA V    14                                                      
REMARK 465     ALA V    15                                                      
REMARK 465     VAL V    16                                                      
REMARK 465     ALA V    17                                                      
REMARK 465     PRO V    18                                                      
REMARK 465     VAL V    19                                                      
REMARK 465     LEU V    20                                                      
REMARK 465     SER V    21                                                      
REMARK 465     ILE V    22                                                      
REMARK 465     ASN V    23                                                      
REMARK 465     SER V    24                                                      
REMARK 465     GLU V   502                                                      
REMARK 465     ILE V   503                                                      
REMARK 465     VAL V   504                                                      
REMARK 465     ASN V   558                                                      
REMARK 465     GLN V   559                                                      
REMARK 465     GLY V   560                                                      
REMARK 465     GLU V   561                                                      
REMARK 465     THR V   562                                                      
REMARK 465     PRO V   563                                                      
REMARK 465     THR V   564                                                      
REMARK 465     THR V   565                                                      
REMARK 465     GLU V   566                                                      
REMARK 465     VAL V   567                                                      
REMARK 465     PRO V   568                                                      
REMARK 465     ALA V   569                                                      
REMARK 465     PRO V   570                                                      
REMARK 465     PHE V   571                                                      
REMARK 465     PHE V   572                                                      
REMARK 465     LEU V   573                                                      
REMARK 465     PRO V   574                                                      
REMARK 465     ALA V   575                                                      
REMARK 465     SER V   576                                                      
REMARK 465     LEU V   577                                                      
REMARK 465     SER V   578                                                      
REMARK 465     ALA V   579                                                      
REMARK 465     ASN V   580                                                      
REMARK 465     ASN V   581                                                      
REMARK 465     THR V   582                                                      
REMARK 465     PRO V   583                                                      
REMARK 465     THR V   584                                                      
REMARK 465     ARG V   585                                                      
REMARK 465     ARG V   586                                                      
REMARK 465     VAL V   587                                                      
REMARK 465     SER V   588                                                      
REMARK 465     PRO V   589                                                      
REMARK 465     LEU V   590                                                      
REMARK 465     ASN V   591                                                      
REMARK 465     LEU V   592                                                      
REMARK 465     SER V   593                                                      
REMARK 465     SER V   594                                                      
REMARK 465     VAL V   595                                                      
REMARK 465     THR V   596                                                      
REMARK 465     PRO V   597                                                      
REMARK 465     MET Z     1                                                      
REMARK 465     ASP Z     2                                                      
REMARK 465     PRO Z     3                                                      
REMARK 465     GLY Z     4                                                      
REMARK 465     ASP Z     5                                                      
REMARK 465     ALA Z     6                                                      
REMARK 465     ALA Z     7                                                      
REMARK 465     ILE Z     8                                                      
REMARK 465     LEU Z     9                                                      
REMARK 465     GLU Z    10                                                      
REMARK 465     SER Z    11                                                      
REMARK 465     SER Z    12                                                      
REMARK 465     LEU Z    13                                                      
REMARK 465     ARG Z    14                                                      
REMARK 465     ILE Z    15                                                      
REMARK 465     LEU Z    16                                                      
REMARK 465     TYR Z    17                                                      
REMARK 465     ARG Z    18                                                      
REMARK 465     LEU Z    19                                                      
REMARK 465     PHE Z    20                                                      
REMARK 465     GLU Z    21                                                      
REMARK 465     SER Z    22                                                      
REMARK 465     VAL Z    23                                                      
REMARK 465     LEU Z    24                                                      
REMARK 465     PRO Z    25                                                      
REMARK 465     PRO Z    26                                                      
REMARK 465     LEU Z    27                                                      
REMARK 465     PRO Z    28                                                      
REMARK 465     ALA Z    29                                                      
REMARK 465     ALA Z    30                                                      
REMARK 465     LEU Z    31                                                      
REMARK 465     GLN Z    32                                                      
REMARK 465     SER Z    33                                                      
REMARK 465     ARG Z    34                                                      
REMARK 465     MET Z    35                                                      
REMARK 465     LYS Z   112                                                      
REMARK 465     THR Z   113                                                      
REMARK 465     SER Z   114                                                      
REMARK 465     LYS Z   115                                                      
REMARK 465     VAL Z   116                                                      
REMARK 465     ARG Z   117                                                      
REMARK 465     PRO Z   118                                                      
REMARK 465     SER Z   119                                                      
REMARK 465     THR Z   120                                                      
REMARK 465     GLY Z   121                                                      
REMARK 465     ASN Z   122                                                      
REMARK 465     SER Z   123                                                      
REMARK 465     ALA Z   124                                                      
REMARK 465     SER Z   125                                                      
REMARK 465     THR Z   126                                                      
REMARK 465     PRO Z   127                                                      
REMARK 465     GLN Z   128                                                      
REMARK 465     SER Z   129                                                      
REMARK 465     GLN Z   130                                                      
REMARK 465     ASN Z   541                                                      
REMARK 465     ASP Z   542                                                      
REMARK 465     GLN Z   543                                                      
REMARK 465     LYS Z   544                                                      
REMARK 465     SER Z   545                                                      
REMARK 465     LEU Z   546                                                      
REMARK 465     GLU Z   547                                                      
REMARK 465     GLY Z   548                                                      
REMARK 465     MET Z   549                                                      
REMARK 465     GLN Z   550                                                      
REMARK 465     LYS Z   551                                                      
REMARK 465     MET Z   552                                                      
REMARK 465     GLU Z   553                                                      
REMARK 465     LYS Z   554                                                      
REMARK 465     GLU Z   555                                                      
REMARK 465     GLU Z   556                                                      
REMARK 465     SER Z   557                                                      
REMARK 465     PRO Z   558                                                      
REMARK 465     THR Z   559                                                      
REMARK 465     ASP Z   560                                                      
REMARK 465     ALA Z   561                                                      
REMARK 465     THR Z   562                                                      
REMARK 465     GLN Z   563                                                      
REMARK 465     GLU Z   564                                                      
REMARK 465     GLU Z   565                                                      
REMARK 465     ASP Z   566                                                      
REMARK 465     VAL Z   567                                                      
REMARK 465     ASP Z   568                                                      
REMARK 465     ASP Z   569                                                      
REMARK 465     MET Z   570                                                      
REMARK 465     GLU Z   571                                                      
REMARK 465     GLY Z   572                                                      
REMARK 465     SER Z   573                                                      
REMARK 465     GLY Z   574                                                      
REMARK 465     GLU Z   575                                                      
REMARK 465     GLU Z   576                                                      
REMARK 465     GLY Z   577                                                      
REMARK 465     ASP Z   578                                                      
REMARK 465     LEU Z   579                                                      
REMARK 465     GLU Z   580                                                      
REMARK 465     GLY Z   581                                                      
REMARK 465     SER Z   582                                                      
REMARK 465     ASP Z   583                                                      
REMARK 465     SER Z   584                                                      
REMARK 465     GLU Z   585                                                      
REMARK 465     ALA Z   586                                                      
REMARK 465     ALA Z   587                                                      
REMARK 465     GLN Z   588                                                      
REMARK 465     TRP Z   589                                                      
REMARK 465     ALA Z   590                                                      
REMARK 465     ASP Z   591                                                      
REMARK 465     GLN Z   592                                                      
REMARK 465     GLU Z   593                                                      
REMARK 465     GLN Z   594                                                      
REMARK 465     TRP Z   595                                                      
REMARK 465     PHE Z   596                                                      
REMARK 465     GLY Z   597                                                      
REMARK 465     MET Z   598                                                      
REMARK 465     GLN Z   599                                                      
REMARK 465     MET R     1                                                      
REMARK 465     ALA R     2                                                      
REMARK 465     GLN R     3                                                      
REMARK 465     PHE R     4                                                      
REMARK 465     ALA R     5                                                      
REMARK 465     PHE R     6                                                      
REMARK 465     GLU R     7                                                      
REMARK 465     SER R     8                                                      
REMARK 465     ASP R     9                                                      
REMARK 465     LEU R    10                                                      
REMARK 465     HIS R    11                                                      
REMARK 465     SER R    12                                                      
REMARK 465     LEU R    13                                                      
REMARK 465     LEU R    14                                                      
REMARK 465     GLN R    15                                                      
REMARK 465     LEU R    16                                                      
REMARK 465     ASP R    17                                                      
REMARK 465     ALA R    18                                                      
REMARK 465     PRO R    19                                                      
REMARK 465     ILE R    20                                                      
REMARK 465     PRO R    21                                                      
REMARK 465     ASN R    22                                                      
REMARK 465     ALA R    23                                                      
REMARK 465     PRO R    24                                                      
REMARK 465     PRO R    25                                                      
REMARK 465     ALA R    26                                                      
REMARK 465     ARG R    27                                                      
REMARK 465     TRP R    28                                                      
REMARK 465     GLN R    29                                                      
REMARK 465     ARG R    30                                                      
REMARK 465     LYS R    31                                                      
REMARK 465     ALA R    32                                                      
REMARK 465     LYS R    33                                                      
REMARK 465     GLU R    34                                                      
REMARK 465     ALA R    35                                                      
REMARK 465     ALA R    36                                                      
REMARK 465     GLY R    37                                                      
REMARK 465     PRO R    38                                                      
REMARK 465     ALA R    39                                                      
REMARK 465     PRO R    40                                                      
REMARK 465     SER R    41                                                      
REMARK 465     PRO R    42                                                      
REMARK 465     MET R    43                                                      
REMARK 465     ARG R    44                                                      
REMARK 465     ALA R    45                                                      
REMARK 465     ALA R    46                                                      
REMARK 465     ASN R    47                                                      
REMARK 465     ARG R    48                                                      
REMARK 465     SER R    49                                                      
REMARK 465     HIS R    50                                                      
REMARK 465     SER R    51                                                      
REMARK 465     ALA R    52                                                      
REMARK 465     GLY R    53                                                      
REMARK 465     ARG R    54                                                      
REMARK 465     THR R    55                                                      
REMARK 465     PRO R    56                                                      
REMARK 465     GLY R    57                                                      
REMARK 465     ARG R    58                                                      
REMARK 465     THR R    59                                                      
REMARK 465     PRO R    60                                                      
REMARK 465     GLY R    61                                                      
REMARK 465     LYS R    62                                                      
REMARK 465     SER R    63                                                      
REMARK 465     SER R    64                                                      
REMARK 465     SER R    65                                                      
REMARK 465     LYS R    66                                                      
REMARK 465     VAL R    67                                                      
REMARK 465     GLN R    68                                                      
REMARK 465     THR R    69                                                      
REMARK 465     THR R    70                                                      
REMARK 465     PRO R    71                                                      
REMARK 465     SER R    72                                                      
REMARK 465     LYS R   136                                                      
REMARK 465     PRO R   137                                                      
REMARK 465     GLN R   138                                                      
REMARK 465     ASN R   139                                                      
REMARK 465     ALA R   140                                                      
REMARK 465     PRO R   141                                                      
REMARK 465     GLU R   142                                                      
REMARK 465     GLY R   143                                                      
REMARK 465     TYR R   144                                                      
REMARK 465     GLN R   145                                                      
REMARK 465     ASN R   146                                                      
REMARK 465     ARG R   147                                                      
REMARK 465     LEU R   148                                                      
REMARK 465     LYS R   149                                                      
REMARK 465     VAL R   150                                                      
REMARK 465     LEU R   151                                                      
REMARK 465     TYR R   152                                                      
REMARK 465     SER R   153                                                      
REMARK 465     GLN R   154                                                      
REMARK 465     LYS R   155                                                      
REMARK 465     ALA R   156                                                      
REMARK 465     THR R   157                                                      
REMARK 465     PRO R   158                                                      
REMARK 465     GLY R   159                                                      
REMARK 465     SER R   160                                                      
REMARK 465     SER R   161                                                      
REMARK 465     ARG R   162                                                      
REMARK 465     LYS R   163                                                      
REMARK 465     THR R   164                                                      
REMARK 465     CYS R   165                                                      
REMARK 465     ARG R   166                                                      
REMARK 465     TYR R   167                                                      
REMARK 465     CYS R   472                                                      
REMARK 465     PHE R   473                                                      
REMARK 465     GLU R   474                                                      
REMARK 465     LEU R   475                                                      
REMARK 465     ASP R   476                                                      
REMARK 465     PRO R   477                                                      
REMARK 465     ALA R   478                                                      
REMARK 465     ARG R   479                                                      
REMARK 465     ARG R   480                                                      
REMARK 465     ARG R   481                                                      
REMARK 465     GLU R   482                                                      
REMARK 465     ARG R   483                                                      
REMARK 465     GLU R   484                                                      
REMARK 465     LYS R   485                                                      
REMARK 465     ALA R   486                                                      
REMARK 465     SER R   487                                                      
REMARK 465     ALA R   488                                                      
REMARK 465     ALA R   489                                                      
REMARK 465     LYS R   490                                                      
REMARK 465     SER R   491                                                      
REMARK 465     MET S     1                                                      
REMARK 465     LEU S     2                                                      
REMARK 465     GLY S     3                                                      
REMARK 465     ASN S     4                                                      
REMARK 465     SER S     5                                                      
REMARK 465     ALA S     6                                                      
REMARK 465     PRO S     7                                                      
REMARK 465     GLY S     8                                                      
REMARK 465     PRO S     9                                                      
REMARK 465     ALA S    10                                                      
REMARK 465     THR S    11                                                      
REMARK 465     ARG S    12                                                      
REMARK 465     GLU S    13                                                      
REMARK 465     ALA S    14                                                      
REMARK 465     GLY S    15                                                      
REMARK 465     SER S    16                                                      
REMARK 465     ALA S    17                                                      
REMARK 465     LEU S    18                                                      
REMARK 465     LEU S    19                                                      
REMARK 465     ALA S    20                                                      
REMARK 465     LEU S    21                                                      
REMARK 465     GLN S    22                                                      
REMARK 465     GLN S    23                                                      
REMARK 465     THR S    24                                                      
REMARK 465     ALA S    25                                                      
REMARK 465     LEU S    26                                                      
REMARK 465     ASP S    82                                                      
REMARK 465     GLU S    83                                                      
REMARK 465     HIS S    84                                                      
REMARK 465     VAL S    85                                                      
REMARK 465     THR S    86                                                      
REMARK 465     VAL S    87                                                      
REMARK 465     PRO S    88                                                      
REMARK 465     PRO S    89                                                      
REMARK 465     TRP S    90                                                      
REMARK 465     LYS S    91                                                      
REMARK 465     ALA S    92                                                      
REMARK 465     ASN S    93                                                      
REMARK 465     SER S    94                                                      
REMARK 465     LYS S    95                                                      
REMARK 465     GLN S    96                                                      
REMARK 465     PRO S    97                                                      
REMARK 465     ALA S    98                                                      
REMARK 465     PHE S    99                                                      
REMARK 465     THR S   100                                                      
REMARK 465     ILE S   101                                                      
REMARK 465     HIS S   102                                                      
REMARK 465     VAL S   103                                                      
REMARK 465     ASP S   104                                                      
REMARK 465     GLU S   105                                                      
REMARK 465     ALA S   106                                                      
REMARK 465     GLU S   107                                                      
REMARK 465     LYS S   108                                                      
REMARK 465     GLU S   109                                                      
REMARK 465     ALA S   110                                                      
REMARK 465     GLN S   111                                                      
REMARK 465     LYS S   112                                                      
REMARK 465     LYS S   113                                                      
REMARK 465     PRO S   114                                                      
REMARK 465     ALA S   115                                                      
REMARK 465     GLU S   116                                                      
REMARK 465     SER S   117                                                      
REMARK 465     GLN S   118                                                      
REMARK 465     LYS S   119                                                      
REMARK 465     ILE S   120                                                      
REMARK 465     GLU S   121                                                      
REMARK 465     ARG S   122                                                      
REMARK 465     GLU S   123                                                      
REMARK 465     ASP S   124                                                      
REMARK 465     ALA S   125                                                      
REMARK 465     LEU S   126                                                      
REMARK 465     ALA S   127                                                      
REMARK 465     PHE S   128                                                      
REMARK 465     ASN S   129                                                      
REMARK 465     SER S   130                                                      
REMARK 465     ALA S   131                                                      
REMARK 465     ILE S   132                                                      
REMARK 465     SER S   133                                                      
REMARK 465     LEU S   134                                                      
REMARK 465     PRO S   135                                                      
REMARK 465     GLY S   136                                                      
REMARK 465     PRO S   137                                                      
REMARK 465     ARG S   138                                                      
REMARK 465     LYS S   139                                                      
REMARK 465     PRO S   140                                                      
REMARK 465     LEU S   141                                                      
REMARK 465     VAL S   142                                                      
REMARK 465     PRO S   143                                                      
REMARK 465     LEU S   144                                                      
REMARK 465     ASP S   145                                                      
REMARK 465     TYR S   146                                                      
REMARK 465     PRO S   147                                                      
REMARK 465     MET S   148                                                      
REMARK 465     ASP S   149                                                      
REMARK 465     GLY S   150                                                      
REMARK 465     SER S   151                                                      
REMARK 465     PHE S   152                                                      
REMARK 465     GLU S   153                                                      
REMARK 465     SER S   154                                                      
REMARK 465     PRO S   155                                                      
REMARK 465     HIS S   156                                                      
REMARK 465     THR S   157                                                      
REMARK 465     MET S   158                                                      
REMARK 465     ASP S   159                                                      
REMARK 465     MET S   160                                                      
REMARK 465     SER S   161                                                      
REMARK 465     ILE S   162                                                      
REMARK 465     ILE S   163                                                      
REMARK 465     LEU S   164                                                      
REMARK 465     GLU S   165                                                      
REMARK 465     ASP S   166                                                      
REMARK 465     GLU S   167                                                      
REMARK 465     LYS S   168                                                      
REMARK 465     PRO S   169                                                      
REMARK 465     VAL S   170                                                      
REMARK 465     SER S   171                                                      
REMARK 465     VAL S   172                                                      
REMARK 465     ASN S   173                                                      
REMARK 465     GLU S   174                                                      
REMARK 465     VAL S   175                                                      
REMARK 465     PRO S   176                                                      
REMARK 465     ASP S   177                                                      
REMARK 465     TYR S   178                                                      
REMARK 465     HIS S   179                                                      
REMARK 465     GLU S   180                                                      
REMARK 465     ASP S   181                                                      
REMARK 465     ILE S   182                                                      
REMARK 465     HIS S   183                                                      
REMARK 465     THR S   184                                                      
REMARK 465     TYR S   185                                                      
REMARK 465     LEU S   186                                                      
REMARK 465     ARG S   187                                                      
REMARK 465     GLU S   188                                                      
REMARK 465     MET S   189                                                      
REMARK 465     GLU S   190                                                      
REMARK 465     VAL S   191                                                      
REMARK 465     LYS S   192                                                      
REMARK 465     CYS S   193                                                      
REMARK 465     LYS S   194                                                      
REMARK 465     PRO S   195                                                      
REMARK 465     LYS S   196                                                      
REMARK 465     VAL S   197                                                      
REMARK 465     GLY S   198                                                      
REMARK 465     TYR S   199                                                      
REMARK 465     MET S   200                                                      
REMARK 465     LYS S   201                                                      
REMARK 465     LYS S   202                                                      
REMARK 465     GLN S   203                                                      
REMARK 465     PRO S   204                                                      
REMARK 465     ASP S   205                                                      
REMARK 465     ILE S   206                                                      
REMARK 465     THR S   207                                                      
REMARK 465     ASN S   208                                                      
REMARK 465     SER S   209                                                      
REMARK 465     MET S   210                                                      
REMARK 465     ARG S   211                                                      
REMARK 465     ALA S   212                                                      
REMARK 465     ILE S   213                                                      
REMARK 465     LEU S   214                                                      
REMARK 465     VAL S   215                                                      
REMARK 465     ASP S   216                                                      
REMARK 465     TRP S   217                                                      
REMARK 465     LEU S   218                                                      
REMARK 465     VAL S   219                                                      
REMARK 465     GLU S   220                                                      
REMARK 465     VAL S   221                                                      
REMARK 465     GLY S   222                                                      
REMARK 465     GLU S   223                                                      
REMARK 465     GLU S   224                                                      
REMARK 465     TYR S   225                                                      
REMARK 465     LYS S   226                                                      
REMARK 465     LEU S   227                                                      
REMARK 465     GLN S   228                                                      
REMARK 465     ASN S   229                                                      
REMARK 465     GLU S   230                                                      
REMARK 465     THR S   231                                                      
REMARK 465     LEU S   232                                                      
REMARK 465     HIS S   233                                                      
REMARK 465     LEU S   234                                                      
REMARK 465     ALA S   235                                                      
REMARK 465     VAL S   236                                                      
REMARK 465     ASN S   237                                                      
REMARK 465     TYR S   238                                                      
REMARK 465     ILE S   239                                                      
REMARK 465     ASP S   240                                                      
REMARK 465     ARG S   241                                                      
REMARK 465     PHE S   242                                                      
REMARK 465     LEU S   243                                                      
REMARK 465     SER S   244                                                      
REMARK 465     SER S   245                                                      
REMARK 465     MET S   246                                                      
REMARK 465     SER S   247                                                      
REMARK 465     VAL S   248                                                      
REMARK 465     LEU S   249                                                      
REMARK 465     ARG S   250                                                      
REMARK 465     GLY S   251                                                      
REMARK 465     LYS S   252                                                      
REMARK 465     LEU S   253                                                      
REMARK 465     GLN S   254                                                      
REMARK 465     LEU S   255                                                      
REMARK 465     VAL S   256                                                      
REMARK 465     GLY S   257                                                      
REMARK 465     THR S   258                                                      
REMARK 465     ALA S   259                                                      
REMARK 465     ALA S   260                                                      
REMARK 465     MET S   261                                                      
REMARK 465     LEU S   262                                                      
REMARK 465     LEU S   263                                                      
REMARK 465     ALA S   264                                                      
REMARK 465     SER S   265                                                      
REMARK 465     LYS S   266                                                      
REMARK 465     PHE S   267                                                      
REMARK 465     GLU S   268                                                      
REMARK 465     GLU S   269                                                      
REMARK 465     ILE S   270                                                      
REMARK 465     TYR S   271                                                      
REMARK 465     PRO S   272                                                      
REMARK 465     PRO S   273                                                      
REMARK 465     GLU S   274                                                      
REMARK 465     VAL S   275                                                      
REMARK 465     ALA S   276                                                      
REMARK 465     GLU S   277                                                      
REMARK 465     PHE S   278                                                      
REMARK 465     VAL S   279                                                      
REMARK 465     TYR S   280                                                      
REMARK 465     ILE S   281                                                      
REMARK 465     THR S   282                                                      
REMARK 465     ASP S   283                                                      
REMARK 465     ASP S   284                                                      
REMARK 465     THR S   285                                                      
REMARK 465     TYR S   286                                                      
REMARK 465     THR S   287                                                      
REMARK 465     LYS S   288                                                      
REMARK 465     LYS S   289                                                      
REMARK 465     GLN S   290                                                      
REMARK 465     VAL S   291                                                      
REMARK 465     LEU S   292                                                      
REMARK 465     ARG S   293                                                      
REMARK 465     MET S   294                                                      
REMARK 465     GLU S   295                                                      
REMARK 465     HIS S   296                                                      
REMARK 465     LEU S   297                                                      
REMARK 465     VAL S   298                                                      
REMARK 465     LEU S   299                                                      
REMARK 465     LYS S   300                                                      
REMARK 465     VAL S   301                                                      
REMARK 465     LEU S   302                                                      
REMARK 465     THR S   303                                                      
REMARK 465     PHE S   304                                                      
REMARK 465     ASP S   305                                                      
REMARK 465     LEU S   306                                                      
REMARK 465     ALA S   307                                                      
REMARK 465     ALA S   308                                                      
REMARK 465     PRO S   309                                                      
REMARK 465     THR S   310                                                      
REMARK 465     VAL S   311                                                      
REMARK 465     ASN S   312                                                      
REMARK 465     GLN S   313                                                      
REMARK 465     PHE S   314                                                      
REMARK 465     LEU S   315                                                      
REMARK 465     THR S   316                                                      
REMARK 465     GLN S   317                                                      
REMARK 465     TYR S   318                                                      
REMARK 465     PHE S   319                                                      
REMARK 465     LEU S   320                                                      
REMARK 465     HIS S   321                                                      
REMARK 465     GLN S   322                                                      
REMARK 465     GLN S   323                                                      
REMARK 465     PRO S   324                                                      
REMARK 465     ALA S   325                                                      
REMARK 465     ASN S   326                                                      
REMARK 465     CYS S   327                                                      
REMARK 465     LYS S   328                                                      
REMARK 465     VAL S   329                                                      
REMARK 465     GLU S   330                                                      
REMARK 465     SER S   331                                                      
REMARK 465     LEU S   332                                                      
REMARK 465     ALA S   333                                                      
REMARK 465     MET S   334                                                      
REMARK 465     PHE S   335                                                      
REMARK 465     LEU S   336                                                      
REMARK 465     GLY S   337                                                      
REMARK 465     GLU S   338                                                      
REMARK 465     LEU S   339                                                      
REMARK 465     SER S   340                                                      
REMARK 465     LEU S   341                                                      
REMARK 465     ILE S   342                                                      
REMARK 465     ASP S   343                                                      
REMARK 465     ALA S   344                                                      
REMARK 465     ASP S   345                                                      
REMARK 465     PRO S   346                                                      
REMARK 465     TYR S   347                                                      
REMARK 465     LEU S   348                                                      
REMARK 465     LYS S   349                                                      
REMARK 465     TYR S   350                                                      
REMARK 465     LEU S   351                                                      
REMARK 465     PRO S   352                                                      
REMARK 465     SER S   353                                                      
REMARK 465     VAL S   354                                                      
REMARK 465     ILE S   355                                                      
REMARK 465     ALA S   356                                                      
REMARK 465     GLY S   357                                                      
REMARK 465     ALA S   358                                                      
REMARK 465     ALA S   359                                                      
REMARK 465     PHE S   360                                                      
REMARK 465     HIS S   361                                                      
REMARK 465     LEU S   362                                                      
REMARK 465     ALA S   363                                                      
REMARK 465     LEU S   364                                                      
REMARK 465     TYR S   365                                                      
REMARK 465     THR S   366                                                      
REMARK 465     VAL S   367                                                      
REMARK 465     THR S   368                                                      
REMARK 465     GLY S   369                                                      
REMARK 465     GLN S   370                                                      
REMARK 465     SER S   371                                                      
REMARK 465     TRP S   372                                                      
REMARK 465     PRO S   373                                                      
REMARK 465     GLU S   374                                                      
REMARK 465     SER S   375                                                      
REMARK 465     LEU S   376                                                      
REMARK 465     ILE S   377                                                      
REMARK 465     ARG S   378                                                      
REMARK 465     LYS S   379                                                      
REMARK 465     THR S   380                                                      
REMARK 465     GLY S   381                                                      
REMARK 465     TYR S   382                                                      
REMARK 465     THR S   383                                                      
REMARK 465     LEU S   384                                                      
REMARK 465     GLU S   385                                                      
REMARK 465     SER S   386                                                      
REMARK 465     LEU S   387                                                      
REMARK 465     LYS S   388                                                      
REMARK 465     PRO S   389                                                      
REMARK 465     CYS S   390                                                      
REMARK 465     LEU S   391                                                      
REMARK 465     MET S   392                                                      
REMARK 465     ASP S   393                                                      
REMARK 465     LEU S   394                                                      
REMARK 465     HIS S   395                                                      
REMARK 465     GLN S   396                                                      
REMARK 465     THR S   397                                                      
REMARK 465     TYR S   398                                                      
REMARK 465     LEU S   399                                                      
REMARK 465     LYS S   400                                                      
REMARK 465     ALA S   401                                                      
REMARK 465     PRO S   402                                                      
REMARK 465     GLN S   403                                                      
REMARK 465     HIS S   404                                                      
REMARK 465     ALA S   405                                                      
REMARK 465     GLN S   406                                                      
REMARK 465     GLN S   407                                                      
REMARK 465     SER S   408                                                      
REMARK 465     ILE S   409                                                      
REMARK 465     ARG S   410                                                      
REMARK 465     GLU S   411                                                      
REMARK 465     LYS S   412                                                      
REMARK 465     TYR S   413                                                      
REMARK 465     LYS S   414                                                      
REMARK 465     ASN S   415                                                      
REMARK 465     SER S   416                                                      
REMARK 465     LYS S   417                                                      
REMARK 465     TYR S   418                                                      
REMARK 465     HIS S   419                                                      
REMARK 465     GLY S   420                                                      
REMARK 465     VAL S   421                                                      
REMARK 465     SER S   422                                                      
REMARK 465     LEU S   423                                                      
REMARK 465     LEU S   424                                                      
REMARK 465     ASN S   425                                                      
REMARK 465     PRO S   426                                                      
REMARK 465     PRO S   427                                                      
REMARK 465     GLU S   428                                                      
REMARK 465     THR S   429                                                      
REMARK 465     LEU S   430                                                      
REMARK 465     ASN S   431                                                      
REMARK 465     LEU S   432                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     LYS L 169    CG   CD   CE   NZ                                   
REMARK 470     GLU A  82    CG   CD   OE1  OE2                                  
REMARK 470     LYS A 137    CG   CD   CE   NZ                                   
REMARK 470     LYS A 140    CG   CD   CE   NZ                                   
REMARK 470     ASN A 145    CG   OD1  ND2                                       
REMARK 470     GLU A 146    CG   CD   OE1  OE2                                  
REMARK 470     GLU A 205    CG   CD   OE1  OE2                                  
REMARK 470     ASP A 241    CG   OD1  OD2                                       
REMARK 470     ASN A 264    CG   OD1  ND2                                       
REMARK 470     GLU A 401    CG   CD   OE1  OE2                                  
REMARK 470     ASN A 461    CG   OD1  ND2                                       
REMARK 470     ASP A 462    CG   OD1  OD2                                       
REMARK 470     THR A 582    OG1  CG2                                            
REMARK 470     ASP A 673    CG   OD1  OD2                                       
REMARK 470     ARG A 674    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG A 815    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     THR A 816    OG1  CG2                                            
REMARK 470     THR A 817    OG1  CG2                                            
REMARK 470     ASP A 824    CG   OD1  OD2                                       
REMARK 470     SER A 892    OG                                                  
REMARK 470     GLU A1010    CG   CD   OE1  OE2                                  
REMARK 470     GLU A1056    CG   CD   OE1  OE2                                  
REMARK 470     ASP A1126    CG   OD1  OD2                                       
REMARK 470     ASP A1318    CG   OD1  OD2                                       
REMARK 470     ARG A1335    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU A1402    CG   CD   OE1  OE2                                  
REMARK 470     GLU A1549    CG   CD   OE1  OE2                                  
REMARK 470     MET A1713    CG   SD   CE                                        
REMARK 470     GLU A1828    CG   CD   OE1  OE2                                  
REMARK 470     GLU A1843    CG   CD   OE1  OE2                                  
REMARK 470     VAL A1862    CG1  CG2                                            
REMARK 470     PRO N  16    CG   CD                                             
REMARK 470     LYS N  51    CG   CD   CE   NZ                                   
REMARK 470     GLU N  52    CG   CD   OE1  OE2                                  
REMARK 470     GLU N  53    CG   CD   OE1  OE2                                  
REMARK 470     GLU N  54    CG   CD   OE1  OE2                                  
REMARK 470     GLU N  60    CG   CD   OE1  OE2                                  
REMARK 470     GLU N  77    CG   CD   OE1  OE2                                  
REMARK 470     ASP N  82    CG   OD1  OD2                                       
REMARK 470     GLU N  99    CG   CD   OE1  OE2                                  
REMARK 470     GLU N 104    CG   CD   OE1  OE2                                  
REMARK 470     ASP N 113    CG   OD1  OD2                                       
REMARK 470     GLU N 119    CG   CD   OE1  OE2                                  
REMARK 470     ASP N 123    CG   OD1  OD2                                       
REMARK 470     ARG N 127    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU N 130    CG   CD   OE1  OE2                                  
REMARK 470     GLU N 133    CG   CD   OE1  OE2                                  
REMARK 470     ARG N 137    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     SER N 314    OG                                                  
REMARK 470     GLU N 316    CG   CD   OE1  OE2                                  
REMARK 470     GLU N 455    CG   CD   OE1  OE2                                  
REMARK 470     ASP N 473    CG   OD1  OD2                                       
REMARK 470     ARG N 496    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU N 610    CG   CD   OE1  OE2                                  
REMARK 470     PHE I 128    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     TYR I 129    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     GLU I 134    CG   CD   OE1  OE2                                  
REMARK 470     LYS I 147    CG   CD   CE   NZ                                   
REMARK 470     ASN I 148    CG   OD1  ND2                                       
REMARK 470     TYR I 149    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     ASN I 151    CG   OD1  ND2                                       
REMARK 470     THR I 152    OG1  CG2                                            
REMARK 470     LYS I 154    CG   CD   CE   NZ                                   
REMARK 470     GLU I 159    CG   CD   OE1  OE2                                  
REMARK 470     ASN I 160    CG   OD1  ND2                                       
REMARK 470     GLU I 293    CG   CD   OE1  OE2                                  
REMARK 470     LYS I 294    CG   CD   CE   NZ                                   
REMARK 470     ASN I 295    CG   OD1  ND2                                       
REMARK 470     THR I 297    OG1  CG2                                            
REMARK 470     LYS I 312    CG   CD   CE   NZ                                   
REMARK 470     GLU I 430    CG   CD   OE1  OE2                                  
REMARK 470     LYS I 439    CG   CD   CE   NZ                                   
REMARK 470     TYR I 469    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     LYS I 480    CG   CD   CE   NZ                                   
REMARK 470     ASP I 484    CG   OD1  OD2                                       
REMARK 470     ASP I 564    CG   OD1  OD2                                       
REMARK 470     SER I 565    OG                                                  
REMARK 470     ARG I 659    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU I 660    CG   CD   OE1  OE2                                  
REMARK 470     ARG I 662    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU I 756    CG   CD   OE1  OE2                                  
REMARK 470     TYR O   9    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     ASN O  11    CG   OD1  ND2                                       
REMARK 470     HIS O  20    CG   ND1  CD2  CE1  NE2                             
REMARK 470     GLU O  49    CG   CD   OE1  OE2                                  
REMARK 470     VAL O  52    CG1  CG2                                            
REMARK 470     MET O  55    CG   SD   CE                                        
REMARK 470     THR O 122    OG1  CG2                                            
REMARK 470     GLU O 123    CG   CD   OE1  OE2                                  
REMARK 470     GLU O 125    CG   CD   OE1  OE2                                  
REMARK 470     LYS O 168    CG   CD   CE   NZ                                   
REMARK 470     THR O 169    OG1  CG2                                            
REMARK 470     SER O 345    OG                                                  
REMARK 470     LYS O 353    CG   CD   CE   NZ                                   
REMARK 470     GLU O 452    CG   CD   OE1  OE2                                  
REMARK 470     GLU K   4    CG   CD   OE1  OE2                                  
REMARK 470     ARG K   5    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASN K 437    CG   OD1  ND2                                       
REMARK 470     GLU K 438    CG   CD   OE1  OE2                                  
REMARK 470     CYS K 544    SG                                                  
REMARK 470     TYR K 545    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     ARG K 566    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASN C  19    CG   OD1  ND2                                       
REMARK 470     ASP C  20    CG   OD1  OD2                                       
REMARK 470     GLU C  21    CG   CD   OE1  OE2                                  
REMARK 470     GLN C  68    CG   CD   OE1  NE2                                  
REMARK 470     VAL C  69    CG1  CG2                                            
REMARK 470     LYS C  83    CG   CD   CE   NZ                                   
REMARK 470     GLU C  84    CG   CD   OE1  OE2                                  
REMARK 470     LYS G  24    CG   CD   CE   NZ                                   
REMARK 470     ASP G  25    CG   OD1  OD2                                       
REMARK 470     GLU G  27    CG   CD   OE1  OE2                                  
REMARK 470     ASP W  25    CG   OD1  OD2                                       
REMARK 470     THR M  46    OG1  CG2                                            
REMARK 470     THR M  47    OG1  CG2                                            
REMARK 470     GLU M  67    CG   CD   OE1  OE2                                  
REMARK 470     GLU H  51    CG   CD   OE1  OE2                                  
REMARK 470     ARG H  52    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLN J   5    CG   CD   OE1  NE2                                  
REMARK 470     LYS J 769    CG   CD   CE   NZ                                   
REMARK 470     LYS J 776    CG   CD   CE   NZ                                   
REMARK 470     GLU J 777    CG   CD   OE1  OE2                                  
REMARK 470     ILE J 779    CG1  CG2  CD1                                       
REMARK 470     ASP J 780    CG   OD1  OD2                                       
REMARK 470     GLN P   5    CG   CD   OE1  NE2                                  
REMARK 470     PHE P 452    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ASP P 767    CG   OD1  OD2                                       
REMARK 470     PRO P 768    CG   CD                                             
REMARK 470     ASN Q   2    CG   OD1  ND2                                       
REMARK 470     GLU Q   4    CG   CD   OE1  OE2                                  
REMARK 470     ARG Q   5    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     MET Q  95    CG   SD   CE                                        
REMARK 470     SER Q 124    OG                                                  
REMARK 470     GLN Q 125    CG   CD   OE1  NE2                                  
REMARK 470     SER Q 126    OG                                                  
REMARK 470     GLU Q 222    CG   CD   OE1  OE2                                  
REMARK 470     ASP Q 529    CG   OD1  OD2                                       
REMARK 470     SER Q 530    OG                                                  
REMARK 470     GLU Q 531    CG   CD   OE1  OE2                                  
REMARK 470     GLU Y 218    CG   CD   OE1  OE2                                  
REMARK 470     LYS Y 264    CG   CD   CE   NZ                                   
REMARK 470     GLU Y 453    CG   CD   OE1  OE2                                  
REMARK 470     ASP Y 454    CG   OD1  OD2                                       
REMARK 470     GLU Y 459    CG   CD   OE1  OE2                                  
REMARK 470     GLU Y 555    CG   CD   OE1  OE2                                  
REMARK 470     LYS U 147    CG   CD   CE   NZ                                   
REMARK 470     LYS U 281    CG   CD   CE   NZ                                   
REMARK 470     ASP U 496    CG   OD1  OD2                                       
REMARK 470     ILE U 497    CD1                                                 
REMARK 470     SER U 499    OG                                                  
REMARK 470     CYS U 500    SG                                                  
REMARK 470     GLU U 505    CG   CD   OE1  OE2                                  
REMARK 470     HIS U 506    CG   ND1  CD2  CE1  NE2                             
REMARK 470     LEU U 507    CG   CD1  CD2                                       
REMARK 470     GLU U 509    CG   CD   OE1  OE2                                  
REMARK 470     LYS U 522    CG   CD   CE   NZ                                   
REMARK 470     LYS U 524    CG   CD   CE   NZ                                   
REMARK 470     CYS U 537    SG                                                  
REMARK 470     PHE U 539    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ASN U 540    CG   OD1  ND2                                       
REMARK 470     ASP U 541    CG   OD1  OD2                                       
REMARK 470     THR U 542    OG1  CG2                                            
REMARK 470     ARG U 543    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU U 544    CG   CD   OE1  OE2                                  
REMARK 470     GLU U 545    CG   CD   OE1  OE2                                  
REMARK 470     LYS U 547    CG   CD   CE   NZ                                   
REMARK 470     LEU U 549    CG   CD1  CD2                                       
REMARK 470     LEU U 550    CG   CD1  CD2                                       
REMARK 470     ARG U 551    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLN U 552    CG   CD   OE1  NE2                                  
REMARK 470     ILE U 553    CG1  CG2  CD1                                       
REMARK 470     LEU U 554    CG   CD1  CD2                                       
REMARK 470     ASP V  25    CG   OD1  OD2                                       
REMARK 470     CYS V 109    SG                                                  
REMARK 470     ASP V 496    CG   OD1  OD2                                       
REMARK 470     SER V 499    OG                                                  
REMARK 470     CYS V 500    SG                                                  
REMARK 470     GLU V 505    CG   CD   OE1  OE2                                  
REMARK 470     HIS V 506    CG   ND1  CD2  CE1  NE2                             
REMARK 470     LEU V 507    CG   CD1  CD2                                       
REMARK 470     GLU V 508    CG   CD   OE1  OE2                                  
REMARK 470     ARG V 514    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS V 522    CG   CD   CE   NZ                                   
REMARK 470     LYS V 524    CG   CD   CE   NZ                                   
REMARK 470     ARG V 543    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG V 551    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG V 557    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     SER Z 111    OG                                                  
REMARK 470     CYS Z 131    SG                                                  
REMARK 470     GLU Z 218    CG   CD   OE1  OE2                                  
REMARK 470     GLU Z 453    CG   CD   OE1  OE2                                  
REMARK 470     ASP Z 454    CG   OD1  OD2                                       
REMARK 470     GLU Z 459    CG   CD   OE1  OE2                                  
REMARK 470     GLN R 100    CG   CD   OE1  NE2                                  
REMARK 470     GLU R 102    CG   CD   OE1  OE2                                  
REMARK 470     ASN R 103    CG   OD1  ND2                                       
REMARK 470     SER R 104    OG                                                  
REMARK 470     GLN R 105    CG   CD   OE1  NE2                                  
REMARK 470     THR R 106    OG1  CG2                                            
REMARK 470     SER R 492    OG                                                  
REMARK 470     LEU R 493    CG   CD1  CD2                                       
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500    ASP A 120   CB  -  CG  -  OD1 ANGL. DEV. =   7.3 DEGREES          
REMARK 500    LEU A 724   CA  -  CB  -  CG  ANGL. DEV. =  15.3 DEGREES          
REMARK 500    LEU A 728   CA  -  CB  -  CG  ANGL. DEV. =  18.0 DEGREES          
REMARK 500    ASP A1356   CB  -  CG  -  OD1 ANGL. DEV. =   6.1 DEGREES          
REMARK 500    ASP A1694   CB  -  CG  -  OD1 ANGL. DEV. =   6.3 DEGREES          
REMARK 500    LEU I 325   CA  -  CB  -  CG  ANGL. DEV. =  16.0 DEGREES          
REMARK 500    ASP Q 442   CB  -  CG  -  OD1 ANGL. DEV. =   9.1 DEGREES          
REMARK 500    LEU Q 451   CA  -  CB  -  CG  ANGL. DEV. =  15.4 DEGREES          
REMARK 500    ASP Y 204   CB  -  CG  -  OD2 ANGL. DEV. =   6.0 DEGREES          
REMARK 500    ILE Z 334   CG1 -  CB  -  CG2 ANGL. DEV. = -15.5 DEGREES          
REMARK 500    CYS Z 405   CA  -  CB  -  SG  ANGL. DEV. =   6.9 DEGREES          
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    PHE L  40       47.27   -140.11                                   
REMARK 500    TYR L  89       32.87    -94.81                                   
REMARK 500    HIS L 103       54.08    -93.71                                   
REMARK 500    GLU L 115       73.77     50.75                                   
REMARK 500    GLN L 146       44.94     38.42                                   
REMARK 500    ASN A  33       -9.24     71.41                                   
REMARK 500    GLU A  85        3.59     57.18                                   
REMARK 500    ALA A 110       30.83   -142.65                                   
REMARK 500    THR A 501      -69.05    -90.63                                   
REMARK 500    LEU A 514       74.89     54.24                                   
REMARK 500    ASN A 593       11.56     58.89                                   
REMARK 500    THR A 817       -0.77     65.90                                   
REMARK 500    ILE A 866      -55.63   -126.77                                   
REMARK 500    LEU A 882      -62.99    -94.55                                   
REMARK 500    SER A 968      -70.26    -83.08                                   
REMARK 500    ASP A 969      -40.05   -136.74                                   
REMARK 500    TRP A 970      -74.15    -54.49                                   
REMARK 500    MET A1016       16.40     59.24                                   
REMARK 500    ASP A1018       48.85    -91.67                                   
REMARK 500    GLU A1030       -0.86     61.11                                   
REMARK 500    ASN A1130       35.17    -98.69                                   
REMARK 500    HIS A1201       75.51     57.02                                   
REMARK 500    TYR A1261       30.97    -95.24                                   
REMARK 500    ASN A1312       57.17    -92.80                                   
REMARK 500    ASN A1320       60.48     62.50                                   
REMARK 500    ASP A1356       12.51     51.43                                   
REMARK 500    ALA A1384        8.29    -69.72                                   
REMARK 500    ASP A1391       -2.17     65.79                                   
REMARK 500    MET A1527       56.69    -98.82                                   
REMARK 500    THR A1546       43.70     37.34                                   
REMARK 500    ASN A1551     -164.19   -123.48                                   
REMARK 500    THR A1597       -5.47     83.09                                   
REMARK 500    ALA A1732       31.47    -94.84                                   
REMARK 500    SER A1743       57.27    -95.83                                   
REMARK 500    GLU A1782       49.70    -86.35                                   
REMARK 500    SER A1806       24.03   -141.48                                   
REMARK 500    THR A1808       10.92     57.69                                   
REMARK 500    ASN A1841       37.06    -98.20                                   
REMARK 500    LYS A1922       45.78     39.35                                   
REMARK 500    SER N 354       51.03    -94.68                                   
REMARK 500    ASP N 486       49.47    -93.49                                   
REMARK 500    LYS N 605      -72.11    -65.46                                   
REMARK 500    THR N 712       53.27    -92.64                                   
REMARK 500    LYS I  66      -61.10    -94.48                                   
REMARK 500    THR I  69      -35.21   -130.45                                   
REMARK 500    LYS I 154       57.65    -94.85                                   
REMARK 500    LEU I 168      -30.43   -131.96                                   
REMARK 500    TYR I 190       17.05     58.89                                   
REMARK 500    ALA I 275       38.08    -98.29                                   
REMARK 500    GLU I 278      -72.60    -65.83                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     120 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS                                         
REMARK 500                                                                      
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH          
REMARK 500 CIS AND TRANS CONFORMATION.  CIS BONDS, IF ANY, ARE LISTED           
REMARK 500 ON CISPEP RECORDS.  TRANS IS DEFINED AS 180 +/- 30 AND               
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.                                  
REMARK 500                                 MODEL     OMEGA                      
REMARK 500 ASP A  969     TRP A  970                 -121.27                    
REMARK 500 TRP A  970     PRO A  971                  143.43                    
REMARK 500 LYS N  630     ALA N  631                  146.91                    
REMARK 500 GLU O  123     PRO O  124                 -141.07                    
REMARK 500 LEU R  202     ASP R  203                 -143.34                    
REMARK 500 LYS S   76     ASP S   77                 -149.33                    
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: EMD-4467   RELATED DB: EMDB                              
REMARK 900 RELATED ID: EMD-4465   RELATED DB: EMDB                              
REMARK 900 RELATED ID: EMD-4464   RELATED DB: EMDB                              
REMARK 900 RELATED ID: EMD-4463   RELATED DB: EMDB                              
REMARK 900 RELATED ID: EMD-4466   RELATED DB: EMDB                              
REMARK 900 CRYO-EM STRUCTURE OF THE APC/C-CDC20-CDK2-CYCLINA2-CKS2 COMPLEX,     
REMARK 900 THE D2 BOX CLASS                                                     
DBREF  6Q6H L    1   185  UNP    Q9UM13   APC10_HUMAN      1    185             
DBREF  6Q6H D    1   121  UNP    P60006   APC15_HUMAN      1    121             
DBREF  6Q6H A    1  1944  PDB    6Q6H     6Q6H             1   1944             
DBREF  6Q6H N    1   822  UNP    Q9UJX6   ANC2_HUMAN       1    822             
DBREF  6Q6H I    1   808  UNP    Q9UJX5   APC4_HUMAN       1    808             
DBREF  6Q6H O    1   755  UNP    Q9UJX4   APC5_HUMAN       1    755             
DBREF  6Q6H K    1   620  UNP    Q13042   CDC16_HUMAN      1    620             
DBREF  6Q6H C    1    84  UNP    Q9NYG5   APC11_HUMAN      1     84             
DBREF  6Q6H G    1    85  UNP    Q8NHZ8   CDC26_HUMAN      1     85             
DBREF  6Q6H W    1    85  UNP    Q8NHZ8   CDC26_HUMAN      1     85             
DBREF  6Q6H M    1    74  UNP    Q9BS18   APC13_HUMAN      1     74             
DBREF  6Q6H H    1   110  UNP    Q96DE5   APC16_HUMAN      1    110             
DBREF  6Q6H J    1   824  UNP    P30260   CDC27_HUMAN      1    824             
DBREF  6Q6H P    1   824  UNP    P30260   CDC27_HUMAN      1    824             
DBREF  6Q6H Q    1   620  UNP    Q13042   CDC16_HUMAN      1    620             
DBREF  6Q6H Y    1   599  UNP    Q9UJX3   APC7_HUMAN       1    599             
DBREF  6Q6H U    1   597  UNP    Q9UJX2   CDC23_HUMAN      1    597             
DBREF  6Q6H V    1   597  UNP    Q9UJX2   CDC23_HUMAN      1    597             
DBREF  6Q6H Z    1   599  UNP    Q9UJX3   APC7_HUMAN       1    599             
DBREF  6Q6H R    1   499  UNP    Q12834   CDC20_HUMAN      1    499             
DBREF  6Q6H S    1   432  UNP    P20248   CCNA2_HUMAN      1    432             
SEQADV 6Q6H     S       UNP  P20248    ASN    34 DELETION                       
SEQADV 6Q6H     S       UNP  P20248    PRO    35 DELETION                       
SEQADV 6Q6H     S       UNP  P20248    GLU    36 DELETION                       
SEQADV 6Q6H     S       UNP  P20248    LYS    37 DELETION                       
SEQADV 6Q6H     S       UNP  P20248    ALA    38 DELETION                       
SEQADV 6Q6H     S       UNP  P20248    ALA    39 DELETION                       
SEQADV 6Q6H     S       UNP  P20248    PRO    40 DELETION                       
SEQADV 6Q6H     S       UNP  P20248    VAL    41 DELETION                       
SEQADV 6Q6H     S       UNP  P20248    GLN    42 DELETION                       
SEQADV 6Q6H     S       UNP  P20248    GLN    43 DELETION                       
SEQADV 6Q6H     S       UNP  P20248    PRO    44 DELETION                       
SEQADV 6Q6H     S       UNP  P20248    ARG    45 DELETION                       
SEQADV 6Q6H     S       UNP  P20248    THR    46 DELETION                       
SEQADV 6Q6H     S       UNP  P20248    ARG    47 DELETION                       
SEQADV 6Q6H     S       UNP  P20248    ALA    48 DELETION                       
SEQADV 6Q6H     S       UNP  P20248    ALA    49 DELETION                       
SEQADV 6Q6H     S       UNP  P20248    LEU    50 DELETION                       
SEQADV 6Q6H     S       UNP  P20248    ALA    51 DELETION                       
SEQADV 6Q6H     S       UNP  P20248    VAL    52 DELETION                       
SEQADV 6Q6H     S       UNP  P20248    LEU    53 DELETION                       
SEQADV 6Q6H     S       UNP  P20248    LYS    54 DELETION                       
SEQADV 6Q6H     S       UNP  P20248    SER    55 DELETION                       
SEQADV 6Q6H     S       UNP  P20248    GLY    56 DELETION                       
SEQADV 6Q6H     S       UNP  P20248    ASN    57 DELETION                       
SEQADV 6Q6H     S       UNP  P20248    PRO    58 DELETION                       
SEQADV 6Q6H     S       UNP  P20248    ARG    59 DELETION                       
SEQADV 6Q6H     S       UNP  P20248    GLY    60 DELETION                       
SEQADV 6Q6H     S       UNP  P20248    LEU    61 DELETION                       
SEQADV 6Q6H     S       UNP  P20248    ALA    62 DELETION                       
SEQADV 6Q6H     S       UNP  P20248    GLN    63 DELETION                       
SEQADV 6Q6H     S       UNP  P20248    GLN    64 DELETION                       
SEQADV 6Q6H     S       UNP  P20248    GLN    65 DELETION                       
SEQADV 6Q6H     S       UNP  P20248    ARG    66 DELETION                       
SEQADV 6Q6H     S       UNP  P20248    PRO    67 DELETION                       
SEQADV 6Q6H     S       UNP  P20248    LYS    68 DELETION                       
SEQADV 6Q6H     S       UNP  P20248    THR    69 DELETION                       
SEQADV 6Q6H     S       UNP  P20248    ARG    70 DELETION                       
SEQADV 6Q6H     S       UNP  P20248    ARG    71 DELETION                       
SEQRES   1 L  185  MET THR THR PRO ASN LYS THR PRO PRO GLY ALA ASP PRO          
SEQRES   2 L  185  LYS GLN LEU GLU ARG THR GLY THR VAL ARG GLU ILE GLY          
SEQRES   3 L  185  SER GLN ALA VAL TRP SER LEU SER SER CYS LYS PRO GLY          
SEQRES   4 L  185  PHE GLY VAL ASP GLN LEU ARG ASP ASP ASN LEU GLU THR          
SEQRES   5 L  185  TYR TRP GLN SER ASP GLY SER GLN PRO HIS LEU VAL ASN          
SEQRES   6 L  185  ILE GLN PHE ARG ARG LYS THR THR VAL LYS THR LEU CYS          
SEQRES   7 L  185  ILE TYR ALA ASP TYR LYS SER ASP GLU SER TYR THR PRO          
SEQRES   8 L  185  SER LYS ILE SER VAL ARG VAL GLY ASN ASN PHE HIS ASN          
SEQRES   9 L  185  LEU GLN GLU ILE ARG GLN LEU GLU LEU VAL GLU PRO SER          
SEQRES  10 L  185  GLY TRP ILE HIS VAL PRO LEU THR ASP ASN HIS LYS LYS          
SEQRES  11 L  185  PRO THR ARG THR PHE MET ILE GLN ILE ALA VAL LEU ALA          
SEQRES  12 L  185  ASN HIS GLN ASN GLY ARG ASP THR HIS MET ARG GLN ILE          
SEQRES  13 L  185  LYS ILE TYR THR PRO VAL GLU GLU SER SER ILE GLY LYS          
SEQRES  14 L  185  PHE PRO ARG CYS THR THR ILE ASP PHE MET MET TYR ARG          
SEQRES  15 L  185  SER ILE ARG                                                  
SEQRES   1 D  121  MET SER THR LEU PHE PRO SER LEU PHE PRO ARG VAL THR          
SEQRES   2 D  121  GLU THR LEU TRP PHE ASN LEU ASP ARG PRO CYS VAL GLU          
SEQRES   3 D  121  GLU THR GLU LEU GLN GLN GLN GLU GLN GLN HIS GLN ALA          
SEQRES   4 D  121  TRP LEU GLN SER ILE ALA GLU LYS ASP ASN ASN LEU VAL          
SEQRES   5 D  121  PRO ILE GLY LYS PRO ALA SER GLU HIS TYR ASP ASP GLU          
SEQRES   6 D  121  GLU GLU GLU ASP ASP GLU ASP ASP GLU ASP SER GLU GLU          
SEQRES   7 D  121  ASP SER GLU ASP ASP GLU ASP MET GLN ASP MET ASP GLU          
SEQRES   8 D  121  MET ASN ASP TYR ASN GLU SER PRO ASP ASP GLY GLU VAL          
SEQRES   9 D  121  ASN GLU VAL ASP MET GLU GLY ASN GLU GLN ASP GLN ASP          
SEQRES  10 D  121  GLN TRP MET ILE                                              
SEQRES   1 A 1855  MET SER ASN PHE TYR GLU GLU ARG THR THR MET ILE ALA          
SEQRES   2 A 1855  ALA ARG ASP LEU GLN GLU PHE VAL PRO PHE GLY ARG ASP          
SEQRES   3 A 1855  HIS CYS LYS HIS HIS PRO ASN ALA LEU ASN LEU GLN LEU          
SEQRES   4 A 1855  ARG GLN LEU GLN PRO ALA SER GLU LEU TRP SER SER ASP          
SEQRES   5 A 1855  GLY ALA ALA GLY LEU VAL GLY SER LEU GLN GLU VAL THR          
SEQRES   6 A 1855  ILE HIS GLU LYS GLN LYS GLU SER TRP GLN LEU ARG LYS          
SEQRES   7 A 1855  GLY VAL SER GLU ILE GLY GLU ASP VAL ASP TYR ASP GLU          
SEQRES   8 A 1855  GLU LEU TYR VAL ALA GLY ASN MET VAL ILE TRP SER LYS          
SEQRES   9 A 1855  GLY SER LYS SER GLN ALA LEU ALA VAL TYR LYS ALA PHE          
SEQRES  10 A 1855  THR VAL ASP SER PRO VAL GLN GLN ALA LEU TRP CYS ASP          
SEQRES  11 A 1855  PHE ILE ILE SER GLN ASP LYS SER GLU LYS ALA TYR SER          
SEQRES  12 A 1855  SER ASN GLU VAL GLU LYS CYS ILE CYS ILE LEU GLN SER          
SEQRES  13 A 1855  SER CYS ILE ASN MET HIS SER ILE GLU GLY LYS ASP TYR          
SEQRES  14 A 1855  ILE ALA SER LEU PRO PHE GLN VAL ALA ASN VAL TRP PRO          
SEQRES  15 A 1855  THR LYS TYR GLY LEU LEU PHE GLU ARG SER ALA SER SER          
SEQRES  16 A 1855  HIS GLU VAL PRO PRO GLY SER PRO ARG GLU PRO LEU PRO          
SEQRES  17 A 1855  THR MET PHE SER MET LEU HIS PRO LEU ASP GLU ILE THR          
SEQRES  18 A 1855  PRO LEU VAL CYS LYS SER GLY SER LEU PHE GLY SER SER          
SEQRES  19 A 1855  ARG VAL GLN TYR VAL VAL ASP HIS ALA MET LYS ILE VAL          
SEQRES  20 A 1855  PHE LEU ASN THR ASP PRO SER ILE VAL MET THR TYR ASP          
SEQRES  21 A 1855  ALA VAL GLN ASN VAL HIS SER VAL TRP THR LEU ARG ARG          
SEQRES  22 A 1855  VAL LYS SER GLU GLU GLU ASN VAL VAL LEU LYS PHE SER          
SEQRES  23 A 1855  GLU GLN GLY GLY THR PRO GLN ASN VAL ALA THR SER SER          
SEQRES  24 A 1855  SER LEU THR ALA HIS LEU ARG LEU ALA PRO GLU THR GLU          
SEQRES  25 A 1855  PRO ILE VAL PRO GLU LEU CYS ILE ASP HIS LEU TRP THR          
SEQRES  26 A 1855  GLU THR ILE THR ASN ILE ARG GLU SER ASN SER GLN ALA          
SEQRES  27 A 1855  SER LYS VAL PHE ILE THR SER ASP LEU CYS GLY GLN LYS          
SEQRES  28 A 1855  PHE LEU CYS PHE LEU VAL GLU SER GLN LEU GLN LEU ARG          
SEQRES  29 A 1855  CYS VAL LYS PHE GLN GLU SER ASN ASP LYS THR GLN LEU          
SEQRES  30 A 1855  ILE PHE GLY SER VAL THR ASN ILE PRO ALA LYS ASP ALA          
SEQRES  31 A 1855  ALA PRO VAL GLU LYS ILE ASP THR MET LEU VAL LEU GLU          
SEQRES  32 A 1855  GLY SER GLY ASN LEU VAL LEU TYR THR GLY VAL VAL ARG          
SEQRES  33 A 1855  VAL GLY LYS VAL PHE ILE PRO GLY LEU PRO ALA PRO SER          
SEQRES  34 A 1855  LEU THR MET SER ASN THR MET PRO ARG PRO SER THR PRO          
SEQRES  35 A 1855  LEU ASP GLY VAL SER THR PRO LYS PRO LEU SER LYS LEU          
SEQRES  36 A 1855  LEU GLY SER LEU ASP GLU VAL VAL LEU LEU SER PRO VAL          
SEQRES  37 A 1855  PRO GLU LEU ARG ASP SER SER LYS LEU HIS ASP SER LEU          
SEQRES  38 A 1855  TYR ASN GLU ASP CYS THR PHE GLN GLN LEU GLY THR TYR          
SEQRES  39 A 1855  ILE HIS SER ILE ARG ASP PRO VAL HIS ASN ARG VAL THR          
SEQRES  40 A 1855  LEU GLU LEU SER ASN GLY SER MET VAL ARG ILE THR ILE          
SEQRES  41 A 1855  PRO GLU ILE ALA THR SER GLU LEU VAL GLN THR CYS LEU          
SEQRES  42 A 1855  GLN ALA ILE LYS PHE ILE LEU PRO LYS GLU ILE ALA VAL          
SEQRES  43 A 1855  GLN MET LEU VAL LYS TRP TYR ASN VAL HIS SER ALA PRO          
SEQRES  44 A 1855  GLY GLY PRO SER TYR HIS SER GLU TRP ASN LEU PHE VAL          
SEQRES  45 A 1855  THR CYS LEU MET ASN MET MET GLY TYR ASN THR ASP ARG          
SEQRES  46 A 1855  LEU ALA TRP THR ARG ASN PHE ASP PHE GLU GLY SER LEU          
SEQRES  47 A 1855  SER PRO VAL ILE ALA PRO LYS LYS ALA ARG PRO SER GLU          
SEQRES  48 A 1855  THR GLY SER ASP ASP ASP TRP GLU TYR LEU LEU ASN SER          
SEQRES  49 A 1855  ASP TYR HIS GLN ASN VAL GLU SER HIS LEU LEU ASN ARG          
SEQRES  50 A 1855  SER LEU CYS LEU SER PRO SER GLU ALA SER GLN MET LYS          
SEQRES  51 A 1855  ASP GLU ASP PHE SER GLN ASN LEU SER LEU ASP SER SER          
SEQRES  52 A 1855  THR LEU LEU PHE THR HIS ILE PRO ALA ILE PHE PHE VAL          
SEQRES  53 A 1855  LEU HIS LEU VAL TYR GLU GLU LEU LYS LEU ASN THR LEU          
SEQRES  54 A 1855  MET GLY GLU GLY ILE CYS SER LEU VAL GLU LEU LEU VAL          
SEQRES  55 A 1855  GLN LEU ALA ARG ASP LEU LYS LEU GLY PRO TYR VAL ASP          
SEQRES  56 A 1855  HIS TYR TYR ARG ASP TYR PRO THR LEU VAL ARG THR THR          
SEQRES  57 A 1855  GLY GLN VAL CYS THR ILE ASP PRO GLY GLN THR GLY PHE          
SEQRES  58 A 1855  MET HIS HIS PRO SER PHE PHE THR SER GLU PRO PRO SER          
SEQRES  59 A 1855  ILE TYR GLN TRP VAL SER SER CYS LEU LYS GLY GLU GLY          
SEQRES  60 A 1855  MET PRO PRO TYR PRO TYR LEU PRO GLY ILE CYS GLU ARG          
SEQRES  61 A 1855  SER ARG LEU VAL VAL LEU SER ILE ALA LEU TYR ILE LEU          
SEQRES  62 A 1855  GLY ASP GLU SER LEU VAL SER ASP GLU SER SER GLN TYR          
SEQRES  63 A 1855  LEU THR ARG ILE THR ILE ALA PRO GLN LYS LEU GLN VAL          
SEQRES  64 A 1855  GLU GLN GLU GLU ASN ARG PHE SER PHE ARG HIS SER THR          
SEQRES  65 A 1855  SER VAL SER SER LEU ALA GLU ARG LEU VAL VAL TRP MET          
SEQRES  66 A 1855  THR ASN VAL GLY PHE THR LEU ARG ASP LEU GLU THR LEU          
SEQRES  67 A 1855  PRO PHE GLY ILE ALA LEU PRO ILE ARG ASP ALA ILE TYR          
SEQRES  68 A 1855  HIS CYS ARG GLU GLN PRO ALA SER ASP TRP PRO GLU ALA          
SEQRES  69 A 1855  VAL CYS LEU LEU ILE GLY ARG GLN ASP LEU SER LYS GLN          
SEQRES  70 A 1855  ALA CYS GLU GLY ASN LEU PRO LYS GLY LYS SER VAL LEU          
SEQRES  71 A 1855  SER SER ASP VAL PRO SER GLY THR GLU THR GLU GLU GLU          
SEQRES  72 A 1855  ASP ASP GLY MET ASN ASP MET ASN HIS GLU VAL MET SER          
SEQRES  73 A 1855  LEU ILE TRP SER GLU ASP LEU ARG VAL GLN ASP VAL ARG          
SEQRES  74 A 1855  ARG LEU LEU GLN SER ALA HIS PRO VAL ARG VAL ASN VAL          
SEQRES  75 A 1855  VAL GLN TYR PRO GLU LEU SER ASP HIS GLU PHE ILE GLU          
SEQRES  76 A 1855  GLU LYS GLU ASN ARG LEU LEU GLN LEU CYS GLN ARG THR          
SEQRES  77 A 1855  MET ALA LEU PRO VAL GLY ARG GLY MET PHE THR LEU PHE          
SEQRES  78 A 1855  SER TYR HIS PRO VAL PRO THR GLU PRO LEU PRO ILE PRO          
SEQRES  79 A 1855  LYS LEU ASN LEU THR GLY ARG ALA PRO PRO ARG ASN THR          
SEQRES  80 A 1855  THR VAL ASP LEU ASN SER GLY ASN ILE ASP VAL PRO PRO          
SEQRES  81 A 1855  ASN MET THR SER TRP ALA SER PHE HIS ASN GLY VAL ALA          
SEQRES  82 A 1855  ALA GLY LEU LYS ILE ALA PRO ALA SER GLN ILE ASP SER          
SEQRES  83 A 1855  ALA TRP ILE VAL TYR ASN LYS PRO LYS HIS ALA GLU LEU          
SEQRES  84 A 1855  ALA ASN GLU TYR ALA GLY PHE LEU MET ALA LEU GLY LEU          
SEQRES  85 A 1855  ASN GLY HIS LEU THR LYS LEU ALA THR LEU ASN ILE HIS          
SEQRES  86 A 1855  ASP TYR LEU THR LYS GLY HIS GLU MET THR SER ILE GLY          
SEQRES  87 A 1855  LEU LEU LEU GLY VAL SER ALA ALA LYS LEU GLY THR MET          
SEQRES  88 A 1855  ASP MET SER ILE THR ARG LEU LEU SER ILE HIS ILE PRO          
SEQRES  89 A 1855  ALA LEU LEU PRO PRO THR SER THR GLU LEU ASP VAL PRO          
SEQRES  90 A 1855  HIS ASN VAL GLN VAL ALA ALA VAL VAL GLY ILE GLY LEU          
SEQRES  91 A 1855  VAL TYR GLN GLY THR ALA HIS ARG HIS THR ALA GLU VAL          
SEQRES  92 A 1855  LEU LEU ALA GLU ILE GLY ARG PRO PRO GLY PRO GLU MET          
SEQRES  93 A 1855  GLU TYR CYS THR ASP ARG GLU SER TYR SER LEU ALA ALA          
SEQRES  94 A 1855  GLY LEU ALA LEU GLY MET VAL CYS LEU GLY HIS GLY SER          
SEQRES  95 A 1855  ASN LEU ILE GLY MET SER ASP LEU ASN VAL PRO GLU GLN          
SEQRES  96 A 1855  LEU TYR GLN TYR MET VAL GLY GLY HIS ARG ARG PHE GLN          
SEQRES  97 A 1855  THR GLY MET HIS ARG GLU LYS HIS LYS SER PRO SER TYR          
SEQRES  98 A 1855  GLN ILE LYS GLU GLY ASP THR ILE ASN VAL ASP VAL THR          
SEQRES  99 A 1855  CYS PRO GLY ALA THR LEU ALA LEU ALA MET ILE TYR LEU          
SEQRES 100 A 1855  LYS THR ASN ASN ARG SER ILE ALA ASP TRP LEU ARG ALA          
SEQRES 101 A 1855  PRO ASP THR MET TYR LEU LEU ASP PHE VAL LYS PRO GLU          
SEQRES 102 A 1855  PHE LEU LEU LEU ARG THR LEU ALA ARG CYS LEU ILE LEU          
SEQRES 103 A 1855  TRP ASP ASP ILE LEU PRO ASN SER LYS TRP VAL ASP SER          
SEQRES 104 A 1855  ASN VAL PRO GLN ILE ILE ARG GLU ASN SER ILE SER LEU          
SEQRES 105 A 1855  SER GLU ILE GLU LEU PRO CYS SER GLU ASP LEU ASN LEU          
SEQRES 106 A 1855  GLU THR LEU SER GLN ALA HIS VAL TYR ILE ILE ALA GLY          
SEQRES 107 A 1855  ALA CYS LEU SER LEU GLY PHE ARG PHE ALA GLY SER GLU          
SEQRES 108 A 1855  ASN LEU SER ALA PHE ASN CYS LEU HIS LYS PHE ALA LYS          
SEQRES 109 A 1855  ASP PHE MET THR TYR LEU SER ALA PRO ASN ALA SER VAL          
SEQRES 110 A 1855  THR GLY PRO HIS ASN LEU GLU THR CYS LEU SER VAL VAL          
SEQRES 111 A 1855  LEU LEU SER LEU ALA MET VAL MET ALA GLY SER GLY ASN          
SEQRES 112 A 1855  LEU LYS VAL LEU GLN LEU CYS ARG PHE LEU HIS MET LYS          
SEQRES 113 A 1855  THR GLY GLY GLU MET ASN TYR GLY PHE HIS LEU ALA HIS          
SEQRES 114 A 1855  HIS MET ALA LEU GLY LEU LEU PHE LEU GLY GLY GLY ARG          
SEQRES 115 A 1855  TYR SER LEU SER THR SER ASN SER SER ILE ALA ALA LEU          
SEQRES 116 A 1855  LEU CYS ALA LEU TYR PRO HIS PHE PRO ALA HIS SER THR          
SEQRES 117 A 1855  ASP ASN ARG TYR HIS LEU GLN ALA LEU ARG HIS LEU TYR          
SEQRES 118 A 1855  VAL LEU ALA ALA GLU PRO ARG LEU LEU VAL PRO VAL ASP          
SEQRES 119 A 1855  VAL ASP THR ASN THR PRO CYS TYR ALA LEU LEU GLU VAL          
SEQRES 120 A 1855  THR TYR LYS GLY THR GLN TRP TYR GLU GLN THR LYS GLU          
SEQRES 121 A 1855  GLU LEU MET ALA PRO THR LEU LEU PRO GLU LEU HIS LEU          
SEQRES 122 A 1855  LEU LYS GLN ILE LYS VAL LYS GLY PRO ARG TYR TRP GLU          
SEQRES 123 A 1855  LEU LEU ILE ASP LEU SER LYS GLY THR GLN HIS LEU LYS          
SEQRES 124 A 1855  SER ILE LEU SER LYS ASP GLY VAL LEU TYR VAL LYS LEU          
SEQRES 125 A 1855  ARG ALA GLY GLN LEU SER TYR LYS GLU ASP PRO MET GLY          
SEQRES 126 A 1855  TRP GLN SER LEU LEU ALA GLN THR VAL ALA ASN ARG ASN          
SEQRES 127 A 1855  SER GLU ALA ARG ALA PHE LYS PRO GLU THR ILE SER ALA          
SEQRES 128 A 1855  PHE THR SER ASP PRO ALA LEU LEU SER PHE ALA GLU TYR          
SEQRES 129 A 1855  PHE CYS LYS PRO THR VAL ASN MET GLY GLN LYS GLN GLU          
SEQRES 130 A 1855  ILE LEU ASP LEU PHE SER SER VAL LEU TYR GLU CYS VAL          
SEQRES 131 A 1855  THR GLN GLU THR PRO GLU MET LEU PRO ALA TYR ILE ALA          
SEQRES 132 A 1855  MET ASP GLN ALA ILE ARG ARG LEU GLY ARG ARG GLU MET          
SEQRES 133 A 1855  SER GLU THR SER GLU LEU TRP GLN ILE LYS LEU VAL LEU          
SEQRES 134 A 1855  GLU PHE PHE SER SER ARG SER HIS GLN GLU ARG LEU GLN          
SEQRES 135 A 1855  ASN HIS PRO LYS ARG GLY LEU PHE MET ASN SER GLU PHE          
SEQRES 136 A 1855  LEU PRO VAL VAL LYS CYS THR ILE ASP ASN THR LEU ASP          
SEQRES 137 A 1855  GLN TRP LEU GLN VAL GLY GLY ASP MET CYS VAL HIS ALA          
SEQRES 138 A 1855  TYR LEU SER GLY GLN PRO LEU GLU GLU SER GLN LEU SER          
SEQRES 139 A 1855  MET LEU ALA CYS PHE LEU VAL TYR HIS SER VAL PRO ALA          
SEQRES 140 A 1855  PRO GLN HIS LEU PRO PRO ILE GLY LEU GLU GLY SER THR          
SEQRES 141 A 1855  SER PHE ALA GLU LEU LEU PHE LYS PHE LYS GLN LEU LYS          
SEQRES 142 A 1855  MET PRO VAL ARG ALA LEU LEU ARG LEU ALA PRO LEU LEU          
SEQRES 143 A 1855  LEU GLY ASN PRO GLN PRO MET VAL MET                          
SEQRES   1 N  822  MET ALA ALA ALA VAL VAL VAL ALA GLU GLY ASP SER ASP          
SEQRES   2 N  822  SER ARG PRO GLY GLN GLU LEU LEU VAL ALA TRP ASN THR          
SEQRES   3 N  822  VAL SER THR GLY LEU VAL PRO PRO ALA ALA LEU GLY LEU          
SEQRES   4 N  822  VAL SER SER ARG THR SER GLY ALA VAL PRO PRO LYS GLU          
SEQRES   5 N  822  GLU GLU LEU ARG ALA ALA VAL GLU VAL LEU ARG GLY HIS          
SEQRES   6 N  822  GLY LEU HIS SER VAL LEU GLU GLU TRP PHE VAL GLU VAL          
SEQRES   7 N  822  LEU GLN ASN ASP LEU GLN ALA ASN ILE SER PRO GLU PHE          
SEQRES   8 N  822  TRP ASN ALA ILE SER GLN CYS GLU ASN SER ALA ASP GLU          
SEQRES   9 N  822  PRO GLN CYS LEU LEU LEU LEU LEU ASP ALA PHE GLY LEU          
SEQRES  10 N  822  LEU GLU SER ARG LEU ASP PRO TYR LEU ARG SER LEU GLU          
SEQRES  11 N  822  LEU LEU GLU LYS TRP THR ARG LEU GLY LEU LEU MET GLY          
SEQRES  12 N  822  THR GLY ALA GLN GLY LEU ARG GLU GLU VAL HIS THR MET          
SEQRES  13 N  822  LEU ARG GLY VAL LEU PHE PHE SER THR PRO ARG THR PHE          
SEQRES  14 N  822  GLN GLU MET ILE GLN ARG LEU TYR GLY CYS PHE LEU ARG          
SEQRES  15 N  822  VAL TYR MET GLN SER LYS ARG LYS GLY GLU GLY GLY THR          
SEQRES  16 N  822  ASP PRO GLU LEU GLU GLY GLU LEU ASP SER ARG TYR ALA          
SEQRES  17 N  822  ARG ARG ARG TYR TYR ARG LEU LEU GLN SER PRO LEU CYS          
SEQRES  18 N  822  ALA GLY CYS SER SER ASP LYS GLN GLN CYS TRP CYS ARG          
SEQRES  19 N  822  GLN ALA LEU GLU GLN PHE HIS GLN LEU SER GLN VAL LEU          
SEQRES  20 N  822  HIS ARG LEU SER LEU LEU GLU ARG VAL SER ALA GLU ALA          
SEQRES  21 N  822  VAL THR THR THR LEU HIS GLN VAL THR ARG GLU ARG MET          
SEQRES  22 N  822  GLU ASP ARG CYS ARG GLY GLU TYR GLU ARG SER PHE LEU          
SEQRES  23 N  822  ARG GLU PHE HIS LYS TRP ILE GLU ARG VAL VAL GLY TRP          
SEQRES  24 N  822  LEU GLY LYS VAL PHE LEU GLN ASP GLY PRO ALA ARG PRO          
SEQRES  25 N  822  ALA SER PRO GLU ALA GLY ASN THR LEU ARG ARG TRP ARG          
SEQRES  26 N  822  CYS HIS VAL GLN ARG PHE PHE TYR ARG ILE TYR ALA SER          
SEQRES  27 N  822  LEU ARG ILE GLU GLU LEU PHE SER ILE VAL ARG ASP PHE          
SEQRES  28 N  822  PRO ASP SER ARG PRO ALA ILE GLU ASP LEU LYS TYR CYS          
SEQRES  29 N  822  LEU GLU ARG THR ASP GLN ARG GLN GLN LEU LEU VAL SER          
SEQRES  30 N  822  LEU LYS ALA ALA LEU GLU THR ARG LEU LEU HIS PRO GLY          
SEQRES  31 N  822  VAL ASN THR CYS ASP ILE ILE THR LEU TYR ILE SER ALA          
SEQRES  32 N  822  ILE LYS ALA LEU ARG VAL LEU ASP PRO SER MET VAL ILE          
SEQRES  33 N  822  LEU GLU VAL ALA CYS GLU PRO ILE ARG ARG TYR LEU ARG          
SEQRES  34 N  822  THR ARG GLU ASP THR VAL ARG GLN ILE VAL ALA GLY LEU          
SEQRES  35 N  822  THR GLY ASP SER ASP GLY THR GLY ASP LEU ALA VAL GLU          
SEQRES  36 N  822  LEU SER LYS THR ASP PRO ALA SER LEU GLU THR GLY GLN          
SEQRES  37 N  822  ASP SER GLU ASP ASP SER GLY GLU PRO GLU ASP TRP VAL          
SEQRES  38 N  822  PRO ASP PRO VAL ASP ALA ASP PRO GLY LYS SER SER SER          
SEQRES  39 N  822  LYS ARG ARG SER SER ASP ILE ILE SER LEU LEU VAL SER          
SEQRES  40 N  822  ILE TYR GLY SER LYS ASP LEU PHE ILE ASN GLU TYR ARG          
SEQRES  41 N  822  SER LEU LEU ALA ASP ARG LEU LEU HIS GLN PHE SER PHE          
SEQRES  42 N  822  SER PRO GLU ARG GLU ILE ARG ASN VAL GLU LEU LEU LYS          
SEQRES  43 N  822  LEU ARG PHE GLY GLU ALA PRO MET HIS PHE CYS GLU VAL          
SEQRES  44 N  822  MET LEU LYS ASP MET ALA ASP SER ARG ARG ILE ASN ALA          
SEQRES  45 N  822  ASN ILE ARG GLU GLU ASP GLU LYS ARG PRO ALA GLU GLU          
SEQRES  46 N  822  GLN PRO PRO PHE GLY VAL TYR ALA VAL ILE LEU SER SER          
SEQRES  47 N  822  GLU PHE TRP PRO PRO PHE LYS ASP GLU LYS LEU GLU VAL          
SEQRES  48 N  822  PRO GLU ASP ILE ARG ALA ALA LEU GLU ALA TYR CYS LYS          
SEQRES  49 N  822  LYS TYR GLU GLN LEU LYS ALA MET ARG THR LEU SER TRP          
SEQRES  50 N  822  LYS HIS THR LEU GLY LEU VAL THR MET ASP VAL GLU LEU          
SEQRES  51 N  822  ALA ASP ARG THR LEU SER VAL ALA VAL THR PRO VAL GLN          
SEQRES  52 N  822  ALA VAL ILE LEU LEU TYR PHE GLN ASP GLN ALA SER TRP          
SEQRES  53 N  822  THR LEU GLU GLU LEU SER LYS ALA VAL LYS MET PRO VAL          
SEQRES  54 N  822  ALA LEU LEU ARG ARG ARG MET SER VAL TRP LEU GLN GLN          
SEQRES  55 N  822  GLY VAL LEU ARG GLU GLU PRO PRO GLY THR PHE SER VAL          
SEQRES  56 N  822  ILE GLU GLU GLU ARG PRO GLN ASP ARG ASP ASN MET VAL          
SEQRES  57 N  822  LEU ILE ASP SER ASP ASP GLU SER ASP SER GLY MET ALA          
SEQRES  58 N  822  SER GLN ALA ASP GLN LYS GLU GLU GLU LEU LEU LEU PHE          
SEQRES  59 N  822  TRP THR TYR ILE GLN ALA MET LEU THR ASN LEU GLU SER          
SEQRES  60 N  822  LEU SER LEU ASP ARG ILE TYR ASN MET LEU ARG MET PHE          
SEQRES  61 N  822  VAL VAL THR GLY PRO ALA LEU ALA GLU ILE ASP LEU GLN          
SEQRES  62 N  822  GLU LEU GLN GLY TYR LEU GLN LYS LYS VAL ARG ASP GLN          
SEQRES  63 N  822  GLN LEU VAL TYR SER ALA GLY VAL TYR ARG LEU PRO LYS          
SEQRES  64 N  822  ASN CYS SER                                                  
SEQRES   1 I  808  MET LEU ARG PHE PRO THR CYS PHE PRO SER PHE ARG VAL          
SEQRES   2 I  808  VAL GLY GLU LYS GLN LEU PRO GLN GLU ILE ILE PHE LEU          
SEQRES   3 I  808  VAL TRP SER PRO LYS ARG ASP LEU ILE ALA LEU ALA ASN          
SEQRES   4 I  808  THR ALA GLY GLU VAL LEU LEU HIS ARG LEU ALA SER PHE          
SEQRES   5 I  808  HIS ARG VAL TRP SER PHE PRO PRO ASN GLU ASN THR GLY          
SEQRES   6 I  808  LYS GLU VAL THR CYS LEU ALA TRP ARG PRO ASP GLY LYS          
SEQRES   7 I  808  LEU LEU ALA PHE ALA LEU ALA ASP THR LYS LYS ILE VAL          
SEQRES   8 I  808  LEU CYS ASP VAL GLU LYS PRO GLU SER LEU HIS SER PHE          
SEQRES   9 I  808  SER VAL GLU ALA PRO VAL SER CYS MET HIS TRP MET GLU          
SEQRES  10 I  808  VAL THR VAL GLU SER SER VAL LEU THR SER PHE TYR ASN          
SEQRES  11 I  808  ALA GLU ASP GLU SER ASN LEU LEU LEU PRO LYS LEU PRO          
SEQRES  12 I  808  THR LEU PRO LYS ASN TYR SER ASN THR SER LYS ILE PHE          
SEQRES  13 I  808  SER GLU GLU ASN SER ASP GLU ILE ILE LYS LEU LEU GLY          
SEQRES  14 I  808  ASP VAL ARG LEU ASN ILE LEU VAL LEU GLY GLY SER SER          
SEQRES  15 I  808  GLY PHE ILE GLU LEU TYR ALA TYR GLY MET PHE LYS ILE          
SEQRES  16 I  808  ALA ARG VAL THR GLY ILE ALA GLY THR CYS LEU ALA LEU          
SEQRES  17 I  808  CYS LEU SER SER ASP LEU LYS SER LEU SER VAL VAL THR          
SEQRES  18 I  808  GLU VAL SER THR ASN GLY ALA SER GLU VAL SER TYR PHE          
SEQRES  19 I  808  GLN LEU GLU THR ASN LEU LEU TYR SER PHE LEU PRO GLU          
SEQRES  20 I  808  VAL THR ARG MET ALA ARG LYS PHE THR HIS ILE SER ALA          
SEQRES  21 I  808  LEU LEU GLN TYR ILE ASN LEU SER LEU THR CYS MET CYS          
SEQRES  22 I  808  GLU ALA TRP GLU GLU ILE LEU MET GLN MET ASP SER ARG          
SEQRES  23 I  808  LEU THR LYS PHE VAL GLN GLU LYS ASN THR THR THR SER          
SEQRES  24 I  808  VAL GLN ASP GLU PHE MET HIS LEU LEU LEU TRP GLY LYS          
SEQRES  25 I  808  ALA SER ALA GLU LEU GLN THR LEU LEU MET ASN GLN LEU          
SEQRES  26 I  808  THR VAL LYS GLY LEU LYS LYS LEU GLY GLN SER ILE GLU          
SEQRES  27 I  808  SER SER TYR SER SER ILE GLN LYS LEU VAL ILE SER HIS          
SEQRES  28 I  808  LEU GLN SER GLY SER GLU SER LEU LEU TYR HIS LEU SER          
SEQRES  29 I  808  GLU LEU LYS GLY MET ALA SER TRP LYS GLN LYS TYR GLU          
SEQRES  30 I  808  PRO LEU GLY LEU ASP ALA ALA GLY ILE GLU GLU ALA ILE          
SEQRES  31 I  808  THR ALA VAL GLY SER PHE ILE LEU LYS ALA ASN GLU LEU          
SEQRES  32 I  808  LEU GLN VAL ILE ASP SER SER MET LYS ASN PHE LYS ALA          
SEQRES  33 I  808  PHE PHE ARG TRP LEU TYR VAL ALA MET LEU ARG MET THR          
SEQRES  34 I  808  GLU ASP HIS VAL LEU PRO GLU LEU ASN LYS MET THR GLN          
SEQRES  35 I  808  LYS ASP ILE THR PHE VAL ALA GLU PHE LEU THR GLU HIS          
SEQRES  36 I  808  PHE ASN GLU ALA PRO ASP LEU TYR ASN ARG LYS GLY LYS          
SEQRES  37 I  808  TYR PHE ASN VAL GLU ARG VAL GLY GLN TYR LEU LYS ASP          
SEQRES  38 I  808  GLU ASP ASP ASP LEU VAL SER PRO PRO ASN THR GLU GLY          
SEQRES  39 I  808  ASN GLN TRP TYR ASP PHE LEU GLN ASN SER SER HIS LEU          
SEQRES  40 I  808  LYS GLU SER PRO LEU LEU PHE PRO TYR TYR PRO ARG LYS          
SEQRES  41 I  808  SER LEU HIS PHE VAL LYS ARG ARG MET GLU ASN ILE ILE          
SEQRES  42 I  808  ASP GLN CYS LEU GLN LYS PRO ALA ASP VAL ILE GLY LYS          
SEQRES  43 I  808  SER MET ASN GLN ALA ILE CYS ILE PRO LEU TYR ARG ASP          
SEQRES  44 I  808  THR ARG SER GLU ASP SER THR ARG ARG LEU PHE LYS PHE          
SEQRES  45 I  808  PRO PHE LEU TRP ASN ASN LYS THR SER ASN LEU HIS TYR          
SEQRES  46 I  808  LEU LEU PHE THR ILE LEU GLU ASP SER LEU TYR LYS MET          
SEQRES  47 I  808  CYS ILE LEU ARG ARG HIS THR ASP ILE SER GLN SER VAL          
SEQRES  48 I  808  SER ASN GLY LEU ILE ALA ILE LYS PHE GLY SER PHE THR          
SEQRES  49 I  808  TYR ALA THR THR GLU LYS VAL ARG ARG SER ILE TYR SER          
SEQRES  50 I  808  CYS LEU ASP ALA GLN PHE TYR ASP ASP GLU THR VAL THR          
SEQRES  51 I  808  VAL VAL LEU LYS ASP THR VAL GLY ARG GLU GLY ARG ASP          
SEQRES  52 I  808  ARG LEU LEU VAL GLN LEU PRO LEU SER LEU VAL TYR ASN          
SEQRES  53 I  808  SER GLU ASP SER ALA GLU TYR GLN PHE THR GLY THR TYR          
SEQRES  54 I  808  SER THR ARG LEU ASP GLU GLN CYS SER ALA ILE PRO THR          
SEQRES  55 I  808  ARG THR MET HIS PHE GLU LYS HIS TRP ARG LEU LEU GLU          
SEQRES  56 I  808  SER MET LYS ALA GLN TYR VAL ALA GLY ASN GLY PHE ARG          
SEQRES  57 I  808  LYS VAL SER CYS VAL LEU SER SER ASN LEU ARG HIS VAL          
SEQRES  58 I  808  ARG VAL PHE GLU MET ASP ILE ASP ASP GLU TRP GLU LEU          
SEQRES  59 I  808  ASP GLU SER SER ASP GLU GLU GLU GLU ALA SER ASN LYS          
SEQRES  60 I  808  PRO VAL LYS ILE LYS GLU GLU VAL LEU SER GLU SER GLU          
SEQRES  61 I  808  ALA GLU ASN GLN GLN ALA GLY ALA ALA ALA LEU ALA PRO          
SEQRES  62 I  808  GLU ILE VAL ILE LYS VAL GLU LYS LEU ASP PRO GLU LEU          
SEQRES  63 I  808  ASP SER                                                      
SEQRES   1 O  755  MET ALA SER VAL HIS GLU SER LEU TYR PHE ASN PRO MET          
SEQRES   2 O  755  MET THR ASN GLY VAL VAL HIS ALA ASN VAL PHE GLY ILE          
SEQRES   3 O  755  LYS ASP TRP VAL THR PRO TYR LYS ILE ALA VAL LEU VAL          
SEQRES   4 O  755  LEU LEU ASN GLU MET SER ARG THR GLY GLU GLY ALA VAL          
SEQRES   5 O  755  SER LEU MET GLU ARG ARG ARG LEU ASN GLN LEU LEU LEU          
SEQRES   6 O  755  PRO LEU LEU GLN GLY PRO ASP ILE THR LEU SER LYS LEU          
SEQRES   7 O  755  TYR LYS LEU ILE GLU GLU SER CYS PRO GLN LEU ALA ASN          
SEQRES   8 O  755  SER VAL GLN ILE ARG ILE LYS LEU MET ALA GLU GLY GLU          
SEQRES   9 O  755  LEU LYS ASP MET GLU GLN PHE PHE ASP ASP LEU SER ASP          
SEQRES  10 O  755  SER PHE SER GLY THR GLU PRO GLU VAL HIS LYS THR SER          
SEQRES  11 O  755  VAL VAL GLY LEU PHE LEU ARG HIS MET ILE LEU ALA TYR          
SEQRES  12 O  755  SER LYS LEU SER PHE SER GLN VAL PHE LYS LEU TYR THR          
SEQRES  13 O  755  ALA LEU GLN GLN TYR PHE GLN ASN GLY GLU LYS LYS THR          
SEQRES  14 O  755  VAL GLU ASP ALA ASP MET GLU LEU THR SER ARG ASP GLU          
SEQRES  15 O  755  GLY GLU ARG LYS MET GLU LYS GLU GLU LEU ASP VAL SER          
SEQRES  16 O  755  VAL ARG GLU GLU GLU VAL SER CYS SER GLY PRO LEU SER          
SEQRES  17 O  755  GLN LYS GLN ALA GLU PHE PHE LEU SER GLN GLN ALA SER          
SEQRES  18 O  755  LEU LEU LYS ASN ASP GLU THR LYS ALA LEU THR PRO ALA          
SEQRES  19 O  755  SER LEU GLN LYS GLU LEU ASN ASN LEU LEU LYS PHE ASN          
SEQRES  20 O  755  PRO ASP PHE ALA GLU ALA HIS TYR LEU SER TYR LEU ASN          
SEQRES  21 O  755  ASN LEU ARG VAL GLN ASP VAL PHE SER SER THR HIS SER          
SEQRES  22 O  755  LEU LEU HIS TYR PHE ASP ARG LEU ILE LEU THR GLY ALA          
SEQRES  23 O  755  GLU SER LYS SER ASN GLY GLU GLU GLY TYR GLY ARG SER          
SEQRES  24 O  755  LEU ARG TYR ALA ALA LEU ASN LEU ALA ALA LEU HIS CYS          
SEQRES  25 O  755  ARG PHE GLY HIS TYR GLN GLN ALA GLU LEU ALA LEU GLN          
SEQRES  26 O  755  GLU ALA ILE ARG ILE ALA GLN GLU SER ASN ASP HIS VAL          
SEQRES  27 O  755  CYS LEU GLN HIS CYS LEU SER TRP LEU TYR VAL LEU GLY          
SEQRES  28 O  755  GLN LYS ARG SER ASP SER TYR VAL LEU LEU GLU HIS SER          
SEQRES  29 O  755  VAL LYS LYS ALA VAL HIS PHE GLY LEU PRO TYR LEU ALA          
SEQRES  30 O  755  SER LEU GLY ILE GLN SER LEU VAL GLN GLN ARG ALA PHE          
SEQRES  31 O  755  ALA GLY LYS THR ALA ASN LYS LEU MET ASP ALA LEU LYS          
SEQRES  32 O  755  ASP SER ASP LEU LEU HIS TRP LYS HIS SER LEU SER GLU          
SEQRES  33 O  755  LEU ILE ASP ILE SER ILE ALA GLN LYS THR ALA ILE TRP          
SEQRES  34 O  755  ARG LEU TYR GLY ARG SER THR MET ALA LEU GLN GLN ALA          
SEQRES  35 O  755  GLN MET LEU LEU SER MET ASN SER LEU GLU ALA VAL ASN          
SEQRES  36 O  755  ALA GLY VAL GLN GLN ASN ASN THR GLU SER PHE ALA VAL          
SEQRES  37 O  755  ALA LEU CYS HIS LEU ALA GLU LEU HIS ALA GLU GLN GLY          
SEQRES  38 O  755  CYS PHE ALA ALA ALA SER GLU VAL LEU LYS HIS LEU LYS          
SEQRES  39 O  755  GLU ARG PHE PRO PRO ASN SER GLN HIS ALA GLN LEU TRP          
SEQRES  40 O  755  MET LEU CYS ASP GLN LYS ILE GLN PHE ASP ARG ALA MET          
SEQRES  41 O  755  ASN ASP GLY LYS TYR HIS LEU ALA ASP SER LEU VAL THR          
SEQRES  42 O  755  GLY ILE THR ALA LEU ASN SER ILE GLU GLY VAL TYR ARG          
SEQRES  43 O  755  LYS ALA VAL VAL LEU GLN ALA GLN ASN GLN MET SER GLU          
SEQRES  44 O  755  ALA HIS LYS LEU LEU GLN LYS LEU LEU VAL HIS CYS GLN          
SEQRES  45 O  755  LYS LEU LYS ASN THR GLU MET VAL ILE SER VAL LEU LEU          
SEQRES  46 O  755  SER VAL ALA GLU LEU TYR TRP ARG SER SER SER PRO THR          
SEQRES  47 O  755  ILE ALA LEU PRO MET LEU LEU GLN ALA LEU ALA LEU SER          
SEQRES  48 O  755  LYS GLU TYR ARG LEU GLN TYR LEU ALA SER GLU THR VAL          
SEQRES  49 O  755  LEU ASN LEU ALA PHE ALA GLN LEU ILE LEU GLY ILE PRO          
SEQRES  50 O  755  GLU GLN ALA LEU SER LEU LEU HIS MET ALA ILE GLU PRO          
SEQRES  51 O  755  ILE LEU ALA ASP GLY ALA ILE LEU ASP LYS GLY ARG ALA          
SEQRES  52 O  755  MET PHE LEU VAL ALA LYS CYS GLN VAL ALA SER ALA ALA          
SEQRES  53 O  755  SER TYR ASP GLN PRO LYS LYS ALA GLU ALA LEU GLU ALA          
SEQRES  54 O  755  ALA ILE GLU ASN LEU ASN GLU ALA LYS ASN TYR PHE ALA          
SEQRES  55 O  755  LYS VAL ASP CYS LYS GLU ARG ILE ARG ASP VAL VAL TYR          
SEQRES  56 O  755  PHE GLN ALA ARG LEU TYR HIS THR LEU GLY LYS THR GLN          
SEQRES  57 O  755  GLU ARG ASN ARG CYS ALA MET LEU PHE ARG GLN LEU HIS          
SEQRES  58 O  755  GLN GLU LEU PRO SER HIS GLY VAL PRO LEU ILE ASN HIS          
SEQRES  59 O  755  LEU                                                          
SEQRES   1 K  620  MET ASN LEU GLU ARG LEU ARG LYS ARG VAL ARG GLN TYR          
SEQRES   2 K  620  LEU ASP GLN GLN GLN TYR GLN SER ALA LEU PHE TRP ALA          
SEQRES   3 K  620  ASP LYS VAL ALA SER LEU SER ARG GLU GLU PRO GLN ASP          
SEQRES   4 K  620  ILE TYR TRP LEU ALA GLN CYS LEU TYR LEU THR ALA GLN          
SEQRES   5 K  620  TYR HIS ARG ALA ALA HIS ALA LEU ARG SER ARG LYS LEU          
SEQRES   6 K  620  ASP LYS LEU TYR GLU ALA CYS ARG TYR LEU ALA ALA ARG          
SEQRES   7 K  620  CYS HIS TYR ALA ALA LYS GLU HIS GLN GLN ALA LEU ASP          
SEQRES   8 K  620  VAL LEU ASP MET GLU GLU PRO ILE ASN LYS ARG LEU PHE          
SEQRES   9 K  620  GLU LYS TYR LEU LYS ASP GLU SER GLY PHE LYS ASP PRO          
SEQRES  10 K  620  SER SER ASP TRP GLU MET SER GLN SER SER ILE LYS SER          
SEQRES  11 K  620  SER ILE CYS LEU LEU ARG GLY LYS ILE TYR ASP ALA LEU          
SEQRES  12 K  620  ASP ASN ARG THR LEU ALA THR TYR SER TYR LYS GLU ALA          
SEQRES  13 K  620  LEU LYS LEU ASP VAL TYR CYS PHE GLU ALA PHE ASP LEU          
SEQRES  14 K  620  LEU THR SER HIS HIS MET LEU THR ALA GLN GLU GLU LYS          
SEQRES  15 K  620  GLU LEU LEU GLU SER LEU PRO LEU SER LYS LEU CYS ASN          
SEQRES  16 K  620  GLU GLU GLN GLU LEU LEU ARG PHE LEU PHE GLU ASN LYS          
SEQRES  17 K  620  LEU LYS LYS TYR ASN LYS PRO SER GLU THR VAL ILE PRO          
SEQRES  18 K  620  GLU SER VAL ASP GLY LEU GLN GLU ASN LEU ASP VAL VAL          
SEQRES  19 K  620  VAL SER LEU ALA GLU ARG HIS TYR TYR ASN CYS ASP PHE          
SEQRES  20 K  620  LYS MET CYS TYR LYS LEU THR SER VAL VAL MET GLU LYS          
SEQRES  21 K  620  ASP PRO PHE HIS ALA SER CYS LEU PRO VAL HIS ILE GLY          
SEQRES  22 K  620  THR LEU VAL GLU LEU ASN LYS ALA ASN GLU LEU PHE TYR          
SEQRES  23 K  620  LEU SER HIS LYS LEU VAL ASP LEU TYR PRO SER ASN PRO          
SEQRES  24 K  620  VAL SER TRP PHE ALA VAL GLY CYS TYR TYR LEU MET VAL          
SEQRES  25 K  620  GLY HIS LYS ASN GLU HIS ALA ARG ARG TYR LEU SER LYS          
SEQRES  26 K  620  ALA THR THR LEU GLU LYS THR TYR GLY PRO ALA TRP ILE          
SEQRES  27 K  620  ALA TYR GLY HIS SER PHE ALA VAL GLU SER GLU HIS ASP          
SEQRES  28 K  620  GLN ALA MET ALA ALA TYR PHE THR ALA ALA GLN LEU MET          
SEQRES  29 K  620  LYS GLY CYS HIS LEU PRO MET LEU TYR ILE GLY LEU GLU          
SEQRES  30 K  620  TYR GLY LEU THR ASN ASN SER LYS LEU ALA GLU ARG PHE          
SEQRES  31 K  620  PHE SER GLN ALA LEU SER ILE ALA PRO GLU ASP PRO PHE          
SEQRES  32 K  620  VAL MET HIS GLU VAL GLY VAL VAL ALA PHE GLN ASN GLY          
SEQRES  33 K  620  GLU TRP LYS THR ALA GLU LYS TRP PHE LEU ASP ALA LEU          
SEQRES  34 K  620  GLU LYS ILE LYS ALA ILE GLY ASN GLU VAL THR VAL ASP          
SEQRES  35 K  620  LYS TRP GLU PRO LEU LEU ASN ASN LEU GLY HIS VAL CYS          
SEQRES  36 K  620  ARG LYS LEU LYS LYS TYR ALA GLU ALA LEU ASP TYR HIS          
SEQRES  37 K  620  ARG GLN ALA LEU VAL LEU ILE PRO GLN ASN ALA SER THR          
SEQRES  38 K  620  TYR SER ALA ILE GLY TYR ILE HIS SER LEU MET GLY ASN          
SEQRES  39 K  620  PHE GLU ASN ALA VAL ASP TYR PHE HIS THR ALA LEU GLY          
SEQRES  40 K  620  LEU ARG ARG ASP ASP THR PHE SER VAL THR MET LEU GLY          
SEQRES  41 K  620  HIS CYS ILE GLU MET TYR ILE GLY ASP SER GLU ALA TYR          
SEQRES  42 K  620  ILE GLY ALA ASP ILE LYS ASP LYS LEU LYS CYS TYR ASP          
SEQRES  43 K  620  PHE ASP VAL HIS THR MET LYS THR LEU LYS ASN ILE ILE          
SEQRES  44 K  620  SER PRO PRO TRP ASP PHE ARG GLU PHE GLU VAL GLU LYS          
SEQRES  45 K  620  GLN THR ALA GLU GLU THR GLY LEU THR PRO LEU GLU THR          
SEQRES  46 K  620  SER ARG LYS THR PRO ASP SER ARG PRO SER LEU GLU GLU          
SEQRES  47 K  620  THR PHE GLU ILE GLU MET ASN GLU SER ASP MET MET LEU          
SEQRES  48 K  620  GLU THR SER MET SER ASP HIS SER THR                          
SEQRES   1 C   84  MET LYS VAL LYS ILE LYS CYS TRP ASN GLY VAL ALA THR          
SEQRES   2 C   84  TRP LEU TRP VAL ALA ASN ASP GLU ASN CYS GLY ILE CYS          
SEQRES   3 C   84  ARG MET ALA PHE ASN GLY CYS CYS PRO ASP CYS LYS VAL          
SEQRES   4 C   84  PRO GLY ASP ASP CYS PRO LEU VAL TRP GLY GLN CYS SER          
SEQRES   5 C   84  HIS CYS PHE HIS MET HIS CYS ILE LEU LYS TRP LEU HIS          
SEQRES   6 C   84  ALA GLN GLN VAL GLN GLN HIS CYS PRO MET CYS ARG GLN          
SEQRES   7 C   84  GLU TRP LYS PHE LYS GLU                                      
SEQRES   1 G   85  MET LEU ARG ARG LYS PRO THR ARG LEU GLU LEU LYS LEU          
SEQRES   2 G   85  ASP ASP ILE GLU GLU PHE GLU ASN ILE ARG LYS ASP LEU          
SEQRES   3 G   85  GLU THR ARG LYS LYS GLN LYS GLU ASP VAL GLU VAL VAL          
SEQRES   4 G   85  GLY GLY SER ASP GLY GLU GLY ALA ILE GLY LEU SER SER          
SEQRES   5 G   85  ASP PRO LYS SER ARG GLU GLN MET ILE ASN ASP ARG ILE          
SEQRES   6 G   85  GLY TYR LYS PRO GLN PRO LYS PRO ASN ASN ARG SER SER          
SEQRES   7 G   85  GLN PHE GLY SER LEU GLU PHE                                  
SEQRES   1 W   85  MET LEU ARG ARG LYS PRO THR ARG LEU GLU LEU LYS LEU          
SEQRES   2 W   85  ASP ASP ILE GLU GLU PHE GLU ASN ILE ARG LYS ASP LEU          
SEQRES   3 W   85  GLU THR ARG LYS LYS GLN LYS GLU ASP VAL GLU VAL VAL          
SEQRES   4 W   85  GLY GLY SER ASP GLY GLU GLY ALA ILE GLY LEU SER SER          
SEQRES   5 W   85  ASP PRO LYS SER ARG GLU GLN MET ILE ASN ASP ARG ILE          
SEQRES   6 W   85  GLY TYR LYS PRO GLN PRO LYS PRO ASN ASN ARG SER SER          
SEQRES   7 W   85  GLN PHE GLY SER LEU GLU PHE                                  
SEQRES   1 M   74  MET ASP SER GLU VAL GLN ARG ASP GLY ARG ILE LEU ASP          
SEQRES   2 M   74  LEU ILE ASP ASP ALA TRP ARG GLU ASP LYS LEU PRO TYR          
SEQRES   3 M   74  GLU ASP VAL ALA ILE PRO LEU ASN GLU LEU PRO GLU PRO          
SEQRES   4 M   74  GLU GLN ASP ASN GLY GLY THR THR GLU SER VAL LYS GLU          
SEQRES   5 M   74  GLN GLU MET LYS TRP THR ASP LEU ALA LEU GLN TYR LEU          
SEQRES   6 M   74  HIS GLU ASN VAL PRO PRO ILE GLY ASN                          
SEQRES   1 H  110  MET ALA ALA SER SER SER SER SER SER ALA GLY GLY VAL          
SEQRES   2 H  110  SER GLY SER SER VAL THR GLY SER GLY PHE SER VAL SER          
SEQRES   3 H  110  ASP LEU ALA PRO PRO ARG LYS ALA LEU PHE THR TYR PRO          
SEQRES   4 H  110  LYS GLY ALA GLY GLU MET LEU GLU ASP GLY SER GLU ARG          
SEQRES   5 H  110  PHE LEU CYS GLU SER VAL PHE SER TYR GLN VAL ALA SER          
SEQRES   6 H  110  THR LEU LYS GLN VAL LYS HIS ASP GLN GLN VAL ALA ARG          
SEQRES   7 H  110  MET GLU LYS LEU ALA GLY LEU VAL GLU GLU LEU GLU ALA          
SEQRES   8 H  110  ASP GLU TRP ARG PHE LYS PRO ILE GLU GLN LEU LEU GLY          
SEQRES   9 H  110  PHE THR PRO SER SER GLY                                      
SEQRES   1 J  824  MET THR VAL LEU GLN GLU PRO VAL GLN ALA ALA ILE TRP          
SEQRES   2 J  824  GLN ALA LEU ASN HIS TYR ALA TYR ARG ASP ALA VAL PHE          
SEQRES   3 J  824  LEU ALA GLU ARG LEU TYR ALA GLU VAL HIS SER GLU GLU          
SEQRES   4 J  824  ALA LEU PHE LEU LEU ALA THR CYS TYR TYR ARG SER GLY          
SEQRES   5 J  824  LYS ALA TYR LYS ALA TYR ARG LEU LEU LYS GLY HIS SER          
SEQRES   6 J  824  CYS THR THR PRO GLN CYS LYS TYR LEU LEU ALA LYS CYS          
SEQRES   7 J  824  CYS VAL ASP LEU SER LYS LEU ALA GLU GLY GLU GLN ILE          
SEQRES   8 J  824  LEU SER GLY GLY VAL PHE ASN LYS GLN LYS SER HIS ASP          
SEQRES   9 J  824  ASP ILE VAL THR GLU PHE GLY ASP SER ALA CYS PHE THR          
SEQRES  10 J  824  LEU SER LEU LEU GLY HIS VAL TYR CYS LYS THR ASP ARG          
SEQRES  11 J  824  LEU ALA LYS GLY SER GLU CYS TYR GLN LYS SER LEU SER          
SEQRES  12 J  824  LEU ASN PRO PHE LEU TRP SER PRO PHE GLU SER LEU CYS          
SEQRES  13 J  824  GLU ILE GLY GLU LYS PRO ASP PRO ASP GLN THR PHE LYS          
SEQRES  14 J  824  PHE THR SER LEU GLN ASN PHE SER ASN CYS LEU PRO ASN          
SEQRES  15 J  824  SER CYS THR THR GLN VAL PRO ASN HIS SER LEU SER HIS          
SEQRES  16 J  824  ARG GLN PRO GLU THR VAL LEU THR GLU THR PRO GLN ASP          
SEQRES  17 J  824  THR ILE GLU LEU ASN ARG LEU ASN LEU GLU SER SER ASN          
SEQRES  18 J  824  SER LYS TYR SER LEU ASN THR ASP SER SER VAL SER TYR          
SEQRES  19 J  824  ILE ASP SER ALA VAL ILE SER PRO ASP THR VAL PRO LEU          
SEQRES  20 J  824  GLY THR GLY THR SER ILE LEU SER LYS GLN VAL GLN ASN          
SEQRES  21 J  824  LYS PRO LYS THR GLY ARG SER LEU LEU GLY GLY PRO ALA          
SEQRES  22 J  824  ALA LEU SER PRO LEU THR PRO SER PHE GLY ILE LEU PRO          
SEQRES  23 J  824  LEU GLU THR PRO SER PRO GLY ASP GLY SER TYR LEU GLN          
SEQRES  24 J  824  ASN TYR THR ASN THR PRO PRO VAL ILE ASP VAL PRO SER          
SEQRES  25 J  824  THR GLY ALA PRO SER LYS LYS SER VAL ALA ARG ILE GLY          
SEQRES  26 J  824  GLN THR GLY THR LYS SER VAL PHE SER GLN SER GLY ASN          
SEQRES  27 J  824  SER ARG GLU VAL THR PRO ILE LEU ALA GLN THR GLN SER          
SEQRES  28 J  824  SER GLY PRO GLN THR SER THR THR PRO GLN VAL LEU SER          
SEQRES  29 J  824  PRO THR ILE THR SER PRO PRO ASN ALA LEU PRO ARG ARG          
SEQRES  30 J  824  SER SER ARG LEU PHE THR SER ASP SER SER THR THR LYS          
SEQRES  31 J  824  GLU ASN SER LYS LYS LEU LYS MET LYS PHE PRO PRO LYS          
SEQRES  32 J  824  ILE PRO ASN ARG LYS THR LYS SER LYS THR ASN LYS GLY          
SEQRES  33 J  824  GLY ILE THR GLN PRO ASN ILE ASN ASP SER LEU GLU ILE          
SEQRES  34 J  824  THR LYS LEU ASP SER SER ILE ILE SER GLU GLY LYS ILE          
SEQRES  35 J  824  SER THR ILE THR PRO GLN ILE GLN ALA PHE ASN LEU GLN          
SEQRES  36 J  824  LYS ALA ALA ALA GLU GLY LEU MET SER LEU LEU ARG GLU          
SEQRES  37 J  824  MET GLY LYS GLY TYR LEU ALA LEU CYS SER TYR ASN CYS          
SEQRES  38 J  824  LYS GLU ALA ILE ASN ILE LEU SER HIS LEU PRO SER HIS          
SEQRES  39 J  824  HIS TYR ASN THR GLY TRP VAL LEU CYS GLN ILE GLY ARG          
SEQRES  40 J  824  ALA TYR PHE GLU LEU SER GLU TYR MET GLN ALA GLU ARG          
SEQRES  41 J  824  ILE PHE SER GLU VAL ARG ARG ILE GLU ASN TYR ARG VAL          
SEQRES  42 J  824  GLU GLY MET GLU ILE TYR SER THR THR LEU TRP HIS LEU          
SEQRES  43 J  824  GLN LYS ASP VAL ALA LEU SER VAL LEU SER LYS ASP LEU          
SEQRES  44 J  824  THR ASP MET ASP LYS ASN SER PRO GLU ALA TRP CYS ALA          
SEQRES  45 J  824  ALA GLY ASN CYS PHE SER LEU GLN ARG GLU HIS ASP ILE          
SEQRES  46 J  824  ALA ILE LYS PHE PHE GLN ARG ALA ILE GLN VAL ASP PRO          
SEQRES  47 J  824  ASN TYR ALA TYR ALA TYR THR LEU LEU GLY HIS GLU PHE          
SEQRES  48 J  824  VAL LEU THR GLU GLU LEU ASP LYS ALA LEU ALA CYS PHE          
SEQRES  49 J  824  ARG ASN ALA ILE ARG VAL ASN PRO ARG HIS TYR ASN ALA          
SEQRES  50 J  824  TRP TYR GLY LEU GLY MET ILE TYR TYR LYS GLN GLU LYS          
SEQRES  51 J  824  PHE SER LEU ALA GLU MET HIS PHE GLN LYS ALA LEU ASP          
SEQRES  52 J  824  ILE ASN PRO GLN SER SER VAL LEU LEU CYS HIS ILE GLY          
SEQRES  53 J  824  VAL VAL GLN HIS ALA LEU LYS LYS SER GLU LYS ALA LEU          
SEQRES  54 J  824  ASP THR LEU ASN LYS ALA ILE VAL ILE ASP PRO LYS ASN          
SEQRES  55 J  824  PRO LEU CYS LYS PHE HIS ARG ALA SER VAL LEU PHE ALA          
SEQRES  56 J  824  ASN GLU LYS TYR LYS SER ALA LEU GLN GLU LEU GLU GLU          
SEQRES  57 J  824  LEU LYS GLN ILE VAL PRO LYS GLU SER LEU VAL TYR PHE          
SEQRES  58 J  824  LEU ILE GLY LYS VAL TYR LYS LYS LEU GLY GLN THR HIS          
SEQRES  59 J  824  LEU ALA LEU MET ASN PHE SER TRP ALA MET ASP LEU ASP          
SEQRES  60 J  824  PRO LYS GLY ALA ASN ASN GLN ILE LYS GLU ALA ILE ASP          
SEQRES  61 J  824  LYS ARG TYR LEU PRO ASP ASP GLU GLU PRO ILE THR GLN          
SEQRES  62 J  824  GLU GLU GLN ILE MET GLY THR ASP GLU SER GLN GLU SER          
SEQRES  63 J  824  SER MET THR ASP ALA ASP ASP THR GLN LEU HIS ALA ALA          
SEQRES  64 J  824  GLU SER ASP GLU PHE                                          
SEQRES   1 P  824  MET THR VAL LEU GLN GLU PRO VAL GLN ALA ALA ILE TRP          
SEQRES   2 P  824  GLN ALA LEU ASN HIS TYR ALA TYR ARG ASP ALA VAL PHE          
SEQRES   3 P  824  LEU ALA GLU ARG LEU TYR ALA GLU VAL HIS SER GLU GLU          
SEQRES   4 P  824  ALA LEU PHE LEU LEU ALA THR CYS TYR TYR ARG SER GLY          
SEQRES   5 P  824  LYS ALA TYR LYS ALA TYR ARG LEU LEU LYS GLY HIS SER          
SEQRES   6 P  824  CYS THR THR PRO GLN CYS LYS TYR LEU LEU ALA LYS CYS          
SEQRES   7 P  824  CYS VAL ASP LEU SER LYS LEU ALA GLU GLY GLU GLN ILE          
SEQRES   8 P  824  LEU SER GLY GLY VAL PHE ASN LYS GLN LYS SER HIS ASP          
SEQRES   9 P  824  ASP ILE VAL THR GLU PHE GLY ASP SER ALA CYS PHE THR          
SEQRES  10 P  824  LEU SER LEU LEU GLY HIS VAL TYR CYS LYS THR ASP ARG          
SEQRES  11 P  824  LEU ALA LYS GLY SER GLU CYS TYR GLN LYS SER LEU SER          
SEQRES  12 P  824  LEU ASN PRO PHE LEU TRP SER PRO PHE GLU SER LEU CYS          
SEQRES  13 P  824  GLU ILE GLY GLU LYS PRO ASP PRO ASP GLN THR PHE LYS          
SEQRES  14 P  824  PHE THR SER LEU GLN ASN PHE SER ASN CYS LEU PRO ASN          
SEQRES  15 P  824  SER CYS THR THR GLN VAL PRO ASN HIS SER LEU SER HIS          
SEQRES  16 P  824  ARG GLN PRO GLU THR VAL LEU THR GLU THR PRO GLN ASP          
SEQRES  17 P  824  THR ILE GLU LEU ASN ARG LEU ASN LEU GLU SER SER ASN          
SEQRES  18 P  824  SER LYS TYR SER LEU ASN THR ASP SER SER VAL SER TYR          
SEQRES  19 P  824  ILE ASP SER ALA VAL ILE SER PRO ASP THR VAL PRO LEU          
SEQRES  20 P  824  GLY THR GLY THR SER ILE LEU SER LYS GLN VAL GLN ASN          
SEQRES  21 P  824  LYS PRO LYS THR GLY ARG SER LEU LEU GLY GLY PRO ALA          
SEQRES  22 P  824  ALA LEU SER PRO LEU THR PRO SER PHE GLY ILE LEU PRO          
SEQRES  23 P  824  LEU GLU THR PRO SER PRO GLY ASP GLY SER TYR LEU GLN          
SEQRES  24 P  824  ASN TYR THR ASN THR PRO PRO VAL ILE ASP VAL PRO SER          
SEQRES  25 P  824  THR GLY ALA PRO SER LYS LYS SER VAL ALA ARG ILE GLY          
SEQRES  26 P  824  GLN THR GLY THR LYS SER VAL PHE SER GLN SER GLY ASN          
SEQRES  27 P  824  SER ARG GLU VAL THR PRO ILE LEU ALA GLN THR GLN SER          
SEQRES  28 P  824  SER GLY PRO GLN THR SER THR THR PRO GLN VAL LEU SER          
SEQRES  29 P  824  PRO THR ILE THR SER PRO PRO ASN ALA LEU PRO ARG ARG          
SEQRES  30 P  824  SER SER ARG LEU PHE THR SER ASP SER SER THR THR LYS          
SEQRES  31 P  824  GLU ASN SER LYS LYS LEU LYS MET LYS PHE PRO PRO LYS          
SEQRES  32 P  824  ILE PRO ASN ARG LYS THR LYS SER LYS THR ASN LYS GLY          
SEQRES  33 P  824  GLY ILE THR GLN PRO ASN ILE ASN ASP SER LEU GLU ILE          
SEQRES  34 P  824  THR LYS LEU ASP SER SER ILE ILE SER GLU GLY LYS ILE          
SEQRES  35 P  824  SER THR ILE THR PRO GLN ILE GLN ALA PHE ASN LEU GLN          
SEQRES  36 P  824  LYS ALA ALA ALA GLU GLY LEU MET SER LEU LEU ARG GLU          
SEQRES  37 P  824  MET GLY LYS GLY TYR LEU ALA LEU CYS SER TYR ASN CYS          
SEQRES  38 P  824  LYS GLU ALA ILE ASN ILE LEU SER HIS LEU PRO SER HIS          
SEQRES  39 P  824  HIS TYR ASN THR GLY TRP VAL LEU CYS GLN ILE GLY ARG          
SEQRES  40 P  824  ALA TYR PHE GLU LEU SER GLU TYR MET GLN ALA GLU ARG          
SEQRES  41 P  824  ILE PHE SER GLU VAL ARG ARG ILE GLU ASN TYR ARG VAL          
SEQRES  42 P  824  GLU GLY MET GLU ILE TYR SER THR THR LEU TRP HIS LEU          
SEQRES  43 P  824  GLN LYS ASP VAL ALA LEU SER VAL LEU SER LYS ASP LEU          
SEQRES  44 P  824  THR ASP MET ASP LYS ASN SER PRO GLU ALA TRP CYS ALA          
SEQRES  45 P  824  ALA GLY ASN CYS PHE SER LEU GLN ARG GLU HIS ASP ILE          
SEQRES  46 P  824  ALA ILE LYS PHE PHE GLN ARG ALA ILE GLN VAL ASP PRO          
SEQRES  47 P  824  ASN TYR ALA TYR ALA TYR THR LEU LEU GLY HIS GLU PHE          
SEQRES  48 P  824  VAL LEU THR GLU GLU LEU ASP LYS ALA LEU ALA CYS PHE          
SEQRES  49 P  824  ARG ASN ALA ILE ARG VAL ASN PRO ARG HIS TYR ASN ALA          
SEQRES  50 P  824  TRP TYR GLY LEU GLY MET ILE TYR TYR LYS GLN GLU LYS          
SEQRES  51 P  824  PHE SER LEU ALA GLU MET HIS PHE GLN LYS ALA LEU ASP          
SEQRES  52 P  824  ILE ASN PRO GLN SER SER VAL LEU LEU CYS HIS ILE GLY          
SEQRES  53 P  824  VAL VAL GLN HIS ALA LEU LYS LYS SER GLU LYS ALA LEU          
SEQRES  54 P  824  ASP THR LEU ASN LYS ALA ILE VAL ILE ASP PRO LYS ASN          
SEQRES  55 P  824  PRO LEU CYS LYS PHE HIS ARG ALA SER VAL LEU PHE ALA          
SEQRES  56 P  824  ASN GLU LYS TYR LYS SER ALA LEU GLN GLU LEU GLU GLU          
SEQRES  57 P  824  LEU LYS GLN ILE VAL PRO LYS GLU SER LEU VAL TYR PHE          
SEQRES  58 P  824  LEU ILE GLY LYS VAL TYR LYS LYS LEU GLY GLN THR HIS          
SEQRES  59 P  824  LEU ALA LEU MET ASN PHE SER TRP ALA MET ASP LEU ASP          
SEQRES  60 P  824  PRO LYS GLY ALA ASN ASN GLN ILE LYS GLU ALA ILE ASP          
SEQRES  61 P  824  LYS ARG TYR LEU PRO ASP ASP GLU GLU PRO ILE THR GLN          
SEQRES  62 P  824  GLU GLU GLN ILE MET GLY THR ASP GLU SER GLN GLU SER          
SEQRES  63 P  824  SER MET THR ASP ALA ASP ASP THR GLN LEU HIS ALA ALA          
SEQRES  64 P  824  GLU SER ASP GLU PHE                                          
SEQRES   1 Q  620  MET ASN LEU GLU ARG LEU ARG LYS ARG VAL ARG GLN TYR          
SEQRES   2 Q  620  LEU ASP GLN GLN GLN TYR GLN SER ALA LEU PHE TRP ALA          
SEQRES   3 Q  620  ASP LYS VAL ALA SER LEU SER ARG GLU GLU PRO GLN ASP          
SEQRES   4 Q  620  ILE TYR TRP LEU ALA GLN CYS LEU TYR LEU THR ALA GLN          
SEQRES   5 Q  620  TYR HIS ARG ALA ALA HIS ALA LEU ARG SER ARG LYS LEU          
SEQRES   6 Q  620  ASP LYS LEU TYR GLU ALA CYS ARG TYR LEU ALA ALA ARG          
SEQRES   7 Q  620  CYS HIS TYR ALA ALA LYS GLU HIS GLN GLN ALA LEU ASP          
SEQRES   8 Q  620  VAL LEU ASP MET GLU GLU PRO ILE ASN LYS ARG LEU PHE          
SEQRES   9 Q  620  GLU LYS TYR LEU LYS ASP GLU SER GLY PHE LYS ASP PRO          
SEQRES  10 Q  620  SER SER ASP TRP GLU MET SER GLN SER SER ILE LYS SER          
SEQRES  11 Q  620  SER ILE CYS LEU LEU ARG GLY LYS ILE TYR ASP ALA LEU          
SEQRES  12 Q  620  ASP ASN ARG THR LEU ALA THR TYR SER TYR LYS GLU ALA          
SEQRES  13 Q  620  LEU LYS LEU ASP VAL TYR CYS PHE GLU ALA PHE ASP LEU          
SEQRES  14 Q  620  LEU THR SER HIS HIS MET LEU THR ALA GLN GLU GLU LYS          
SEQRES  15 Q  620  GLU LEU LEU GLU SER LEU PRO LEU SER LYS LEU CYS ASN          
SEQRES  16 Q  620  GLU GLU GLN GLU LEU LEU ARG PHE LEU PHE GLU ASN LYS          
SEQRES  17 Q  620  LEU LYS LYS TYR ASN LYS PRO SER GLU THR VAL ILE PRO          
SEQRES  18 Q  620  GLU SER VAL ASP GLY LEU GLN GLU ASN LEU ASP VAL VAL          
SEQRES  19 Q  620  VAL SER LEU ALA GLU ARG HIS TYR TYR ASN CYS ASP PHE          
SEQRES  20 Q  620  LYS MET CYS TYR LYS LEU THR SER VAL VAL MET GLU LYS          
SEQRES  21 Q  620  ASP PRO PHE HIS ALA SER CYS LEU PRO VAL HIS ILE GLY          
SEQRES  22 Q  620  THR LEU VAL GLU LEU ASN LYS ALA ASN GLU LEU PHE TYR          
SEQRES  23 Q  620  LEU SER HIS LYS LEU VAL ASP LEU TYR PRO SER ASN PRO          
SEQRES  24 Q  620  VAL SER TRP PHE ALA VAL GLY CYS TYR TYR LEU MET VAL          
SEQRES  25 Q  620  GLY HIS LYS ASN GLU HIS ALA ARG ARG TYR LEU SER LYS          
SEQRES  26 Q  620  ALA THR THR LEU GLU LYS THR TYR GLY PRO ALA TRP ILE          
SEQRES  27 Q  620  ALA TYR GLY HIS SER PHE ALA VAL GLU SER GLU HIS ASP          
SEQRES  28 Q  620  GLN ALA MET ALA ALA TYR PHE THR ALA ALA GLN LEU MET          
SEQRES  29 Q  620  LYS GLY CYS HIS LEU PRO MET LEU TYR ILE GLY LEU GLU          
SEQRES  30 Q  620  TYR GLY LEU THR ASN ASN SER LYS LEU ALA GLU ARG PHE          
SEQRES  31 Q  620  PHE SER GLN ALA LEU SER ILE ALA PRO GLU ASP PRO PHE          
SEQRES  32 Q  620  VAL MET HIS GLU VAL GLY VAL VAL ALA PHE GLN ASN GLY          
SEQRES  33 Q  620  GLU TRP LYS THR ALA GLU LYS TRP PHE LEU ASP ALA LEU          
SEQRES  34 Q  620  GLU LYS ILE LYS ALA ILE GLY ASN GLU VAL THR VAL ASP          
SEQRES  35 Q  620  LYS TRP GLU PRO LEU LEU ASN ASN LEU GLY HIS VAL CYS          
SEQRES  36 Q  620  ARG LYS LEU LYS LYS TYR ALA GLU ALA LEU ASP TYR HIS          
SEQRES  37 Q  620  ARG GLN ALA LEU VAL LEU ILE PRO GLN ASN ALA SER THR          
SEQRES  38 Q  620  TYR SER ALA ILE GLY TYR ILE HIS SER LEU MET GLY ASN          
SEQRES  39 Q  620  PHE GLU ASN ALA VAL ASP TYR PHE HIS THR ALA LEU GLY          
SEQRES  40 Q  620  LEU ARG ARG ASP ASP THR PHE SER VAL THR MET LEU GLY          
SEQRES  41 Q  620  HIS CYS ILE GLU MET TYR ILE GLY ASP SER GLU ALA TYR          
SEQRES  42 Q  620  ILE GLY ALA ASP ILE LYS ASP LYS LEU LYS CYS TYR ASP          
SEQRES  43 Q  620  PHE ASP VAL HIS THR MET LYS THR LEU LYS ASN ILE ILE          
SEQRES  44 Q  620  SER PRO PRO TRP ASP PHE ARG GLU PHE GLU VAL GLU LYS          
SEQRES  45 Q  620  GLN THR ALA GLU GLU THR GLY LEU THR PRO LEU GLU THR          
SEQRES  46 Q  620  SER ARG LYS THR PRO ASP SER ARG PRO SER LEU GLU GLU          
SEQRES  47 Q  620  THR PHE GLU ILE GLU MET ASN GLU SER ASP MET MET LEU          
SEQRES  48 Q  620  GLU THR SER MET SER ASP HIS SER THR                          
SEQRES   1 Y  599  MET ASP PRO GLY ASP ALA ALA ILE LEU GLU SER SER LEU          
SEQRES   2 Y  599  ARG ILE LEU TYR ARG LEU PHE GLU SER VAL LEU PRO PRO          
SEQRES   3 Y  599  LEU PRO ALA ALA LEU GLN SER ARG MET ASN VAL ILE ASP          
SEQRES   4 Y  599  HIS VAL ARG ASP MET ALA ALA ALA GLY LEU HIS SER ASN          
SEQRES   5 Y  599  VAL ARG LEU LEU SER SER LEU LEU LEU THR MET SER ASN          
SEQRES   6 Y  599  ASN ASN PRO GLU LEU PHE SER PRO PRO GLN LYS TYR GLN          
SEQRES   7 Y  599  LEU LEU VAL TYR HIS ALA ASP SER LEU PHE HIS ASP LYS          
SEQRES   8 Y  599  GLU TYR ARG ASN ALA VAL SER LYS TYR THR MET ALA LEU          
SEQRES   9 Y  599  GLN GLN LYS LYS ALA LEU SER LYS THR SER LYS VAL ARG          
SEQRES  10 Y  599  PRO SER THR GLY ASN SER ALA SER THR PRO GLN SER GLN          
SEQRES  11 Y  599  CYS LEU PRO SER GLU ILE GLU VAL LYS TYR LYS MET ALA          
SEQRES  12 Y  599  GLU CYS TYR THR MET LEU LYS GLN ASP LYS ASP ALA ILE          
SEQRES  13 Y  599  ALA ILE LEU ASP GLY ILE PRO SER ARG GLN ARG THR PRO          
SEQRES  14 Y  599  LYS ILE ASN MET MET LEU ALA ASN LEU TYR LYS LYS ALA          
SEQRES  15 Y  599  GLY GLN GLU ARG PRO SER VAL THR SER TYR LYS GLU VAL          
SEQRES  16 Y  599  LEU ARG GLN CYS PRO LEU ALA LEU ASP ALA ILE LEU GLY          
SEQRES  17 Y  599  LEU LEU SER LEU SER VAL LYS GLY ALA GLU VAL ALA SER          
SEQRES  18 Y  599  MET THR MET ASN VAL ILE GLN THR VAL PRO ASN LEU ASP          
SEQRES  19 Y  599  TRP LEU SER VAL TRP ILE LYS ALA TYR ALA PHE VAL HIS          
SEQRES  20 Y  599  THR GLY ASP ASN SER ARG ALA ILE SER THR ILE CYS SER          
SEQRES  21 Y  599  LEU GLU LYS LYS SER LEU LEU ARG ASP ASN VAL ASP LEU          
SEQRES  22 Y  599  LEU GLY SER LEU ALA ASP LEU TYR PHE ARG ALA GLY ASP          
SEQRES  23 Y  599  ASN LYS ASN SER VAL LEU LYS PHE GLU GLN ALA GLN MET          
SEQRES  24 Y  599  LEU ASP PRO TYR LEU ILE LYS GLY MET ASP VAL TYR GLY          
SEQRES  25 Y  599  TYR LEU LEU ALA ARG GLU GLY ARG LEU GLU ASP VAL GLU          
SEQRES  26 Y  599  ASN LEU GLY CYS ARG LEU PHE ASN ILE SER ASP GLN HIS          
SEQRES  27 Y  599  ALA GLU PRO TRP VAL VAL SER GLY CYS HIS SER PHE TYR          
SEQRES  28 Y  599  SER LYS ARG TYR SER ARG ALA LEU TYR LEU GLY ALA LYS          
SEQRES  29 Y  599  ALA ILE GLN LEU ASN SER ASN SER VAL GLN ALA LEU LEU          
SEQRES  30 Y  599  LEU LYS GLY ALA ALA LEU ARG ASN MET GLY ARG VAL GLN          
SEQRES  31 Y  599  GLU ALA ILE ILE HIS PHE ARG GLU ALA ILE ARG LEU ALA          
SEQRES  32 Y  599  PRO CYS ARG LEU ASP CYS TYR GLU GLY LEU ILE GLU CYS          
SEQRES  33 Y  599  TYR LEU ALA SER ASN SER ILE ARG GLU ALA MET VAL MET          
SEQRES  34 Y  599  ALA ASN ASN VAL TYR LYS THR LEU GLY ALA ASN ALA GLN          
SEQRES  35 Y  599  THR LEU THR LEU LEU ALA THR VAL CYS LEU GLU ASP PRO          
SEQRES  36 Y  599  VAL THR GLN GLU LYS ALA LYS THR LEU LEU ASP LYS ALA          
SEQRES  37 Y  599  LEU THR GLN ARG PRO ASP TYR ILE LYS ALA VAL VAL LYS          
SEQRES  38 Y  599  LYS ALA GLU LEU LEU SER ARG GLU GLN LYS TYR GLU ASP          
SEQRES  39 Y  599  GLY ILE ALA LEU LEU ARG ASN ALA LEU ALA ASN GLN SER          
SEQRES  40 Y  599  ASP CYS VAL LEU HIS ARG ILE LEU GLY ASP PHE LEU VAL          
SEQRES  41 Y  599  ALA VAL ASN GLU TYR GLN GLU ALA MET ASP GLN TYR SER          
SEQRES  42 Y  599  ILE ALA LEU SER LEU ASP PRO ASN ASP GLN LYS SER LEU          
SEQRES  43 Y  599  GLU GLY MET GLN LYS MET GLU LYS GLU GLU SER PRO THR          
SEQRES  44 Y  599  ASP ALA THR GLN GLU GLU ASP VAL ASP ASP MET GLU GLY          
SEQRES  45 Y  599  SER GLY GLU GLU GLY ASP LEU GLU GLY SER ASP SER GLU          
SEQRES  46 Y  599  ALA ALA GLN TRP ALA ASP GLN GLU GLN TRP PHE GLY MET          
SEQRES  47 Y  599  GLN                                                          
SEQRES   1 U  597  MET ALA ALA SER THR SER MET VAL PRO VAL ALA VAL THR          
SEQRES   2 U  597  ALA ALA VAL ALA PRO VAL LEU SER ILE ASN SER ASP PHE          
SEQRES   3 U  597  SER ASP LEU ARG GLU ILE LYS LYS GLN LEU LEU LEU ILE          
SEQRES   4 U  597  ALA GLY LEU THR ARG GLU ARG GLY LEU LEU HIS SER SER          
SEQRES   5 U  597  LYS TRP SER ALA GLU LEU ALA PHE SER LEU PRO ALA LEU          
SEQRES   6 U  597  PRO LEU ALA GLU LEU GLN PRO PRO PRO PRO ILE THR GLU          
SEQRES   7 U  597  GLU ASP ALA GLN ASP MET ASP ALA TYR THR LEU ALA LYS          
SEQRES   8 U  597  ALA TYR PHE ASP VAL LYS GLU TYR ASP ARG ALA ALA HIS          
SEQRES   9 U  597  PHE LEU HIS GLY CYS ASN SER LYS LYS ALA TYR PHE LEU          
SEQRES  10 U  597  TYR MET TYR SER ARG TYR LEU SER GLY GLU LYS LYS LYS          
SEQRES  11 U  597  ASP ASP GLU THR VAL ASP SER LEU GLY PRO LEU GLU LYS          
SEQRES  12 U  597  GLY GLN VAL LYS ASN GLU ALA LEU ARG GLU LEU ARG VAL          
SEQRES  13 U  597  GLU LEU SER LYS LYS HIS GLN ALA ARG GLU LEU ASP GLY          
SEQRES  14 U  597  PHE GLY LEU TYR LEU TYR GLY VAL VAL LEU ARG LYS LEU          
SEQRES  15 U  597  ASP LEU VAL LYS GLU ALA ILE ASP VAL PHE VAL GLU ALA          
SEQRES  16 U  597  THR HIS VAL LEU PRO LEU HIS TRP GLY ALA TRP LEU GLU          
SEQRES  17 U  597  LEU CYS ASN LEU ILE THR ASP LYS GLU MET LEU LYS PHE          
SEQRES  18 U  597  LEU SER LEU PRO ASP THR TRP MET LYS GLU PHE PHE LEU          
SEQRES  19 U  597  ALA HIS ILE TYR THR GLU LEU GLN LEU ILE GLU GLU ALA          
SEQRES  20 U  597  LEU GLN LYS TYR GLN ASN LEU ILE ASP VAL GLY PHE SER          
SEQRES  21 U  597  LYS SER SER TYR ILE VAL SER GLN ILE ALA VAL ALA TYR          
SEQRES  22 U  597  HIS ASN ILE ARG ASP ILE ASP LYS ALA LEU SER ILE PHE          
SEQRES  23 U  597  ASN GLU LEU ARG LYS GLN ASP PRO TYR ARG ILE GLU ASN          
SEQRES  24 U  597  MET ASP THR PHE SER ASN LEU LEU TYR VAL ARG SER MET          
SEQRES  25 U  597  LYS SER GLU LEU SER TYR LEU ALA HIS ASN LEU CYS GLU          
SEQRES  26 U  597  ILE ASP LYS TYR ARG VAL GLU THR CYS CYS VAL ILE GLY          
SEQRES  27 U  597  ASN TYR TYR SER LEU ARG SER GLN HIS GLU LYS ALA ALA          
SEQRES  28 U  597  LEU TYR PHE GLN ARG ALA LEU LYS LEU ASN PRO ARG TYR          
SEQRES  29 U  597  LEU GLY ALA TRP THR LEU MET GLY HIS GLU TYR MET GLU          
SEQRES  30 U  597  MET LYS ASN THR SER ALA ALA ILE GLN ALA TYR ARG HIS          
SEQRES  31 U  597  ALA ILE GLU VAL ASN LYS ARG ASP TYR ARG ALA TRP TYR          
SEQRES  32 U  597  GLY LEU GLY GLN THR TYR GLU ILE LEU LYS MET PRO PHE          
SEQRES  33 U  597  TYR CYS LEU TYR TYR TYR ARG ARG ALA HIS GLN LEU ARG          
SEQRES  34 U  597  PRO ASN ASP SER ARG MET LEU VAL ALA LEU GLY GLU CYS          
SEQRES  35 U  597  TYR GLU LYS LEU ASN GLN LEU VAL GLU ALA LYS LYS CYS          
SEQRES  36 U  597  TYR TRP ARG ALA TYR ALA VAL GLY ASP VAL GLU LYS MET          
SEQRES  37 U  597  ALA LEU VAL LYS LEU ALA LYS LEU HIS GLU GLN LEU THR          
SEQRES  38 U  597  GLU SER GLU GLN ALA ALA GLN CYS TYR ILE LYS TYR ILE          
SEQRES  39 U  597  GLN ASP ILE TYR SER CYS GLY GLU ILE VAL GLU HIS LEU          
SEQRES  40 U  597  GLU GLU SER THR ALA PHE ARG TYR LEU ALA GLN TYR TYR          
SEQRES  41 U  597  PHE LYS CYS LYS LEU TRP ASP GLU ALA SER THR CYS ALA          
SEQRES  42 U  597  GLN LYS CYS CYS ALA PHE ASN ASP THR ARG GLU GLU GLY          
SEQRES  43 U  597  LYS ALA LEU LEU ARG GLN ILE LEU GLN LEU ARG ASN GLN          
SEQRES  44 U  597  GLY GLU THR PRO THR THR GLU VAL PRO ALA PRO PHE PHE          
SEQRES  45 U  597  LEU PRO ALA SER LEU SER ALA ASN ASN THR PRO THR ARG          
SEQRES  46 U  597  ARG VAL SER PRO LEU ASN LEU SER SER VAL THR PRO              
SEQRES   1 V  597  MET ALA ALA SER THR SER MET VAL PRO VAL ALA VAL THR          
SEQRES   2 V  597  ALA ALA VAL ALA PRO VAL LEU SER ILE ASN SER ASP PHE          
SEQRES   3 V  597  SER ASP LEU ARG GLU ILE LYS LYS GLN LEU LEU LEU ILE          
SEQRES   4 V  597  ALA GLY LEU THR ARG GLU ARG GLY LEU LEU HIS SER SER          
SEQRES   5 V  597  LYS TRP SER ALA GLU LEU ALA PHE SER LEU PRO ALA LEU          
SEQRES   6 V  597  PRO LEU ALA GLU LEU GLN PRO PRO PRO PRO ILE THR GLU          
SEQRES   7 V  597  GLU ASP ALA GLN ASP MET ASP ALA TYR THR LEU ALA LYS          
SEQRES   8 V  597  ALA TYR PHE ASP VAL LYS GLU TYR ASP ARG ALA ALA HIS          
SEQRES   9 V  597  PHE LEU HIS GLY CYS ASN SER LYS LYS ALA TYR PHE LEU          
SEQRES  10 V  597  TYR MET TYR SER ARG TYR LEU SER GLY GLU LYS LYS LYS          
SEQRES  11 V  597  ASP ASP GLU THR VAL ASP SER LEU GLY PRO LEU GLU LYS          
SEQRES  12 V  597  GLY GLN VAL LYS ASN GLU ALA LEU ARG GLU LEU ARG VAL          
SEQRES  13 V  597  GLU LEU SER LYS LYS HIS GLN ALA ARG GLU LEU ASP GLY          
SEQRES  14 V  597  PHE GLY LEU TYR LEU TYR GLY VAL VAL LEU ARG LYS LEU          
SEQRES  15 V  597  ASP LEU VAL LYS GLU ALA ILE ASP VAL PHE VAL GLU ALA          
SEQRES  16 V  597  THR HIS VAL LEU PRO LEU HIS TRP GLY ALA TRP LEU GLU          
SEQRES  17 V  597  LEU CYS ASN LEU ILE THR ASP LYS GLU MET LEU LYS PHE          
SEQRES  18 V  597  LEU SER LEU PRO ASP THR TRP MET LYS GLU PHE PHE LEU          
SEQRES  19 V  597  ALA HIS ILE TYR THR GLU LEU GLN LEU ILE GLU GLU ALA          
SEQRES  20 V  597  LEU GLN LYS TYR GLN ASN LEU ILE ASP VAL GLY PHE SER          
SEQRES  21 V  597  LYS SER SER TYR ILE VAL SER GLN ILE ALA VAL ALA TYR          
SEQRES  22 V  597  HIS ASN ILE ARG ASP ILE ASP LYS ALA LEU SER ILE PHE          
SEQRES  23 V  597  ASN GLU LEU ARG LYS GLN ASP PRO TYR ARG ILE GLU ASN          
SEQRES  24 V  597  MET ASP THR PHE SER ASN LEU LEU TYR VAL ARG SER MET          
SEQRES  25 V  597  LYS SER GLU LEU SER TYR LEU ALA HIS ASN LEU CYS GLU          
SEQRES  26 V  597  ILE ASP LYS TYR ARG VAL GLU THR CYS CYS VAL ILE GLY          
SEQRES  27 V  597  ASN TYR TYR SER LEU ARG SER GLN HIS GLU LYS ALA ALA          
SEQRES  28 V  597  LEU TYR PHE GLN ARG ALA LEU LYS LEU ASN PRO ARG TYR          
SEQRES  29 V  597  LEU GLY ALA TRP THR LEU MET GLY HIS GLU TYR MET GLU          
SEQRES  30 V  597  MET LYS ASN THR SER ALA ALA ILE GLN ALA TYR ARG HIS          
SEQRES  31 V  597  ALA ILE GLU VAL ASN LYS ARG ASP TYR ARG ALA TRP TYR          
SEQRES  32 V  597  GLY LEU GLY GLN THR TYR GLU ILE LEU LYS MET PRO PHE          
SEQRES  33 V  597  TYR CYS LEU TYR TYR TYR ARG ARG ALA HIS GLN LEU ARG          
SEQRES  34 V  597  PRO ASN ASP SER ARG MET LEU VAL ALA LEU GLY GLU CYS          
SEQRES  35 V  597  TYR GLU LYS LEU ASN GLN LEU VAL GLU ALA LYS LYS CYS          
SEQRES  36 V  597  TYR TRP ARG ALA TYR ALA VAL GLY ASP VAL GLU LYS MET          
SEQRES  37 V  597  ALA LEU VAL LYS LEU ALA LYS LEU HIS GLU GLN LEU THR          
SEQRES  38 V  597  GLU SER GLU GLN ALA ALA GLN CYS TYR ILE LYS TYR ILE          
SEQRES  39 V  597  GLN ASP ILE TYR SER CYS GLY GLU ILE VAL GLU HIS LEU          
SEQRES  40 V  597  GLU GLU SER THR ALA PHE ARG TYR LEU ALA GLN TYR TYR          
SEQRES  41 V  597  PHE LYS CYS LYS LEU TRP ASP GLU ALA SER THR CYS ALA          
SEQRES  42 V  597  GLN LYS CYS CYS ALA PHE ASN ASP THR ARG GLU GLU GLY          
SEQRES  43 V  597  LYS ALA LEU LEU ARG GLN ILE LEU GLN LEU ARG ASN GLN          
SEQRES  44 V  597  GLY GLU THR PRO THR THR GLU VAL PRO ALA PRO PHE PHE          
SEQRES  45 V  597  LEU PRO ALA SER LEU SER ALA ASN ASN THR PRO THR ARG          
SEQRES  46 V  597  ARG VAL SER PRO LEU ASN LEU SER SER VAL THR PRO              
SEQRES   1 Z  599  MET ASP PRO GLY ASP ALA ALA ILE LEU GLU SER SER LEU          
SEQRES   2 Z  599  ARG ILE LEU TYR ARG LEU PHE GLU SER VAL LEU PRO PRO          
SEQRES   3 Z  599  LEU PRO ALA ALA LEU GLN SER ARG MET ASN VAL ILE ASP          
SEQRES   4 Z  599  HIS VAL ARG ASP MET ALA ALA ALA GLY LEU HIS SER ASN          
SEQRES   5 Z  599  VAL ARG LEU LEU SER SER LEU LEU LEU THR MET SER ASN          
SEQRES   6 Z  599  ASN ASN PRO GLU LEU PHE SER PRO PRO GLN LYS TYR GLN          
SEQRES   7 Z  599  LEU LEU VAL TYR HIS ALA ASP SER LEU PHE HIS ASP LYS          
SEQRES   8 Z  599  GLU TYR ARG ASN ALA VAL SER LYS TYR THR MET ALA LEU          
SEQRES   9 Z  599  GLN GLN LYS LYS ALA LEU SER LYS THR SER LYS VAL ARG          
SEQRES  10 Z  599  PRO SER THR GLY ASN SER ALA SER THR PRO GLN SER GLN          
SEQRES  11 Z  599  CYS LEU PRO SER GLU ILE GLU VAL LYS TYR LYS MET ALA          
SEQRES  12 Z  599  GLU CYS TYR THR MET LEU LYS GLN ASP LYS ASP ALA ILE          
SEQRES  13 Z  599  ALA ILE LEU ASP GLY ILE PRO SER ARG GLN ARG THR PRO          
SEQRES  14 Z  599  LYS ILE ASN MET MET LEU ALA ASN LEU TYR LYS LYS ALA          
SEQRES  15 Z  599  GLY GLN GLU ARG PRO SER VAL THR SER TYR LYS GLU VAL          
SEQRES  16 Z  599  LEU ARG GLN CYS PRO LEU ALA LEU ASP ALA ILE LEU GLY          
SEQRES  17 Z  599  LEU LEU SER LEU SER VAL LYS GLY ALA GLU VAL ALA SER          
SEQRES  18 Z  599  MET THR MET ASN VAL ILE GLN THR VAL PRO ASN LEU ASP          
SEQRES  19 Z  599  TRP LEU SER VAL TRP ILE LYS ALA TYR ALA PHE VAL HIS          
SEQRES  20 Z  599  THR GLY ASP ASN SER ARG ALA ILE SER THR ILE CYS SER          
SEQRES  21 Z  599  LEU GLU LYS LYS SER LEU LEU ARG ASP ASN VAL ASP LEU          
SEQRES  22 Z  599  LEU GLY SER LEU ALA ASP LEU TYR PHE ARG ALA GLY ASP          
SEQRES  23 Z  599  ASN LYS ASN SER VAL LEU LYS PHE GLU GLN ALA GLN MET          
SEQRES  24 Z  599  LEU ASP PRO TYR LEU ILE LYS GLY MET ASP VAL TYR GLY          
SEQRES  25 Z  599  TYR LEU LEU ALA ARG GLU GLY ARG LEU GLU ASP VAL GLU          
SEQRES  26 Z  599  ASN LEU GLY CYS ARG LEU PHE ASN ILE SER ASP GLN HIS          
SEQRES  27 Z  599  ALA GLU PRO TRP VAL VAL SER GLY CYS HIS SER PHE TYR          
SEQRES  28 Z  599  SER LYS ARG TYR SER ARG ALA LEU TYR LEU GLY ALA LYS          
SEQRES  29 Z  599  ALA ILE GLN LEU ASN SER ASN SER VAL GLN ALA LEU LEU          
SEQRES  30 Z  599  LEU LYS GLY ALA ALA LEU ARG ASN MET GLY ARG VAL GLN          
SEQRES  31 Z  599  GLU ALA ILE ILE HIS PHE ARG GLU ALA ILE ARG LEU ALA          
SEQRES  32 Z  599  PRO CYS ARG LEU ASP CYS TYR GLU GLY LEU ILE GLU CYS          
SEQRES  33 Z  599  TYR LEU ALA SER ASN SER ILE ARG GLU ALA MET VAL MET          
SEQRES  34 Z  599  ALA ASN ASN VAL TYR LYS THR LEU GLY ALA ASN ALA GLN          
SEQRES  35 Z  599  THR LEU THR LEU LEU ALA THR VAL CYS LEU GLU ASP PRO          
SEQRES  36 Z  599  VAL THR GLN GLU LYS ALA LYS THR LEU LEU ASP LYS ALA          
SEQRES  37 Z  599  LEU THR GLN ARG PRO ASP TYR ILE LYS ALA VAL VAL LYS          
SEQRES  38 Z  599  LYS ALA GLU LEU LEU SER ARG GLU GLN LYS TYR GLU ASP          
SEQRES  39 Z  599  GLY ILE ALA LEU LEU ARG ASN ALA LEU ALA ASN GLN SER          
SEQRES  40 Z  599  ASP CYS VAL LEU HIS ARG ILE LEU GLY ASP PHE LEU VAL          
SEQRES  41 Z  599  ALA VAL ASN GLU TYR GLN GLU ALA MET ASP GLN TYR SER          
SEQRES  42 Z  599  ILE ALA LEU SER LEU ASP PRO ASN ASP GLN LYS SER LEU          
SEQRES  43 Z  599  GLU GLY MET GLN LYS MET GLU LYS GLU GLU SER PRO THR          
SEQRES  44 Z  599  ASP ALA THR GLN GLU GLU ASP VAL ASP ASP MET GLU GLY          
SEQRES  45 Z  599  SER GLY GLU GLU GLY ASP LEU GLU GLY SER ASP SER GLU          
SEQRES  46 Z  599  ALA ALA GLN TRP ALA ASP GLN GLU GLN TRP PHE GLY MET          
SEQRES  47 Z  599  GLN                                                          
SEQRES   1 R  499  MET ALA GLN PHE ALA PHE GLU SER ASP LEU HIS SER LEU          
SEQRES   2 R  499  LEU GLN LEU ASP ALA PRO ILE PRO ASN ALA PRO PRO ALA          
SEQRES   3 R  499  ARG TRP GLN ARG LYS ALA LYS GLU ALA ALA GLY PRO ALA          
SEQRES   4 R  499  PRO SER PRO MET ARG ALA ALA ASN ARG SER HIS SER ALA          
SEQRES   5 R  499  GLY ARG THR PRO GLY ARG THR PRO GLY LYS SER SER SER          
SEQRES   6 R  499  LYS VAL GLN THR THR PRO SER LYS PRO GLY GLY ASP ARG          
SEQRES   7 R  499  TYR ILE PRO HIS ARG SER ALA ALA GLN MET GLU VAL ALA          
SEQRES   8 R  499  SER PHE LEU LEU SER LYS GLU ASN GLN PRO GLU ASN SER          
SEQRES   9 R  499  GLN THR PRO THR LYS LYS GLU HIS GLN LYS ALA TRP ALA          
SEQRES  10 R  499  LEU ASN LEU ASN GLY PHE ASP VAL GLU GLU ALA LYS ILE          
SEQRES  11 R  499  LEU ARG LEU SER GLY LYS PRO GLN ASN ALA PRO GLU GLY          
SEQRES  12 R  499  TYR GLN ASN ARG LEU LYS VAL LEU TYR SER GLN LYS ALA          
SEQRES  13 R  499  THR PRO GLY SER SER ARG LYS THR CYS ARG TYR ILE PRO          
SEQRES  14 R  499  SER LEU PRO ASP ARG ILE LEU ASP ALA PRO GLU ILE ARG          
SEQRES  15 R  499  ASN ASP TYR TYR LEU ASN LEU VAL ASP TRP SER SER GLY          
SEQRES  16 R  499  ASN VAL LEU ALA VAL ALA LEU ASP ASN SER VAL TYR LEU          
SEQRES  17 R  499  TRP SER ALA SER SER GLY ASP ILE LEU GLN LEU LEU GLN          
SEQRES  18 R  499  MET GLU GLN PRO GLY GLU TYR ILE SER SER VAL ALA TRP          
SEQRES  19 R  499  ILE LYS GLU GLY ASN TYR LEU ALA VAL GLY THR SER SER          
SEQRES  20 R  499  ALA GLU VAL GLN LEU TRP ASP VAL GLN GLN GLN LYS ARG          
SEQRES  21 R  499  LEU ARG ASN MET THR SER HIS SER ALA ARG VAL GLY SER          
SEQRES  22 R  499  LEU SER TRP ASN SER TYR ILE LEU SER SER GLY SER ARG          
SEQRES  23 R  499  SER GLY HIS ILE HIS HIS HIS ASP VAL ARG VAL ALA GLU          
SEQRES  24 R  499  HIS HIS VAL ALA THR LEU SER GLY HIS SER GLN GLU VAL          
SEQRES  25 R  499  CYS GLY LEU ARG TRP ALA PRO ASP GLY ARG HIS LEU ALA          
SEQRES  26 R  499  SER GLY GLY ASN ASP ASN LEU VAL ASN VAL TRP PRO SER          
SEQRES  27 R  499  ALA PRO GLY GLU GLY GLY TRP VAL PRO LEU GLN THR PHE          
SEQRES  28 R  499  THR GLN HIS GLN GLY ALA VAL LYS ALA VAL ALA TRP CYS          
SEQRES  29 R  499  PRO TRP GLN SER ASN VAL LEU ALA THR GLY GLY GLY THR          
SEQRES  30 R  499  SER ASP ARG HIS ILE ARG ILE TRP ASN VAL CYS SER GLY          
SEQRES  31 R  499  ALA CYS LEU SER ALA VAL ASP ALA HIS SER GLN VAL CYS          
SEQRES  32 R  499  SER ILE LEU TRP SER PRO HIS TYR LYS GLU LEU ILE SER          
SEQRES  33 R  499  GLY HIS GLY PHE ALA GLN ASN GLN LEU VAL ILE TRP LYS          
SEQRES  34 R  499  TYR PRO THR MET ALA LYS VAL ALA GLU LEU LYS GLY HIS          
SEQRES  35 R  499  THR SER ARG VAL LEU SER LEU THR MET SER PRO ASP GLY          
SEQRES  36 R  499  ALA THR VAL ALA SER ALA ALA ALA ASP GLU THR LEU ARG          
SEQRES  37 R  499  LEU TRP ARG CYS PHE GLU LEU ASP PRO ALA ARG ARG ARG          
SEQRES  38 R  499  GLU ARG GLU LYS ALA SER ALA ALA LYS SER SER LEU ILE          
SEQRES  39 R  499  HIS GLN GLY ILE ARG                                          
SEQRES   1 S  394  MET LEU GLY ASN SER ALA PRO GLY PRO ALA THR ARG GLU          
SEQRES   2 S  394  ALA GLY SER ALA LEU LEU ALA LEU GLN GLN THR ALA LEU          
SEQRES   3 S  394  GLN GLU ASP GLN GLU ASN ILE VAL ALA PRO LEU LYS ASP          
SEQRES   4 S  394  LEU PRO VAL ASN ASP GLU HIS VAL THR VAL PRO PRO TRP          
SEQRES   5 S  394  LYS ALA ASN SER LYS GLN PRO ALA PHE THR ILE HIS VAL          
SEQRES   6 S  394  ASP GLU ALA GLU LYS GLU ALA GLN LYS LYS PRO ALA GLU          
SEQRES   7 S  394  SER GLN LYS ILE GLU ARG GLU ASP ALA LEU ALA PHE ASN          
SEQRES   8 S  394  SER ALA ILE SER LEU PRO GLY PRO ARG LYS PRO LEU VAL          
SEQRES   9 S  394  PRO LEU ASP TYR PRO MET ASP GLY SER PHE GLU SER PRO          
SEQRES  10 S  394  HIS THR MET ASP MET SER ILE ILE LEU GLU ASP GLU LYS          
SEQRES  11 S  394  PRO VAL SER VAL ASN GLU VAL PRO ASP TYR HIS GLU ASP          
SEQRES  12 S  394  ILE HIS THR TYR LEU ARG GLU MET GLU VAL LYS CYS LYS          
SEQRES  13 S  394  PRO LYS VAL GLY TYR MET LYS LYS GLN PRO ASP ILE THR          
SEQRES  14 S  394  ASN SER MET ARG ALA ILE LEU VAL ASP TRP LEU VAL GLU          
SEQRES  15 S  394  VAL GLY GLU GLU TYR LYS LEU GLN ASN GLU THR LEU HIS          
SEQRES  16 S  394  LEU ALA VAL ASN TYR ILE ASP ARG PHE LEU SER SER MET          
SEQRES  17 S  394  SER VAL LEU ARG GLY LYS LEU GLN LEU VAL GLY THR ALA          
SEQRES  18 S  394  ALA MET LEU LEU ALA SER LYS PHE GLU GLU ILE TYR PRO          
SEQRES  19 S  394  PRO GLU VAL ALA GLU PHE VAL TYR ILE THR ASP ASP THR          
SEQRES  20 S  394  TYR THR LYS LYS GLN VAL LEU ARG MET GLU HIS LEU VAL          
SEQRES  21 S  394  LEU LYS VAL LEU THR PHE ASP LEU ALA ALA PRO THR VAL          
SEQRES  22 S  394  ASN GLN PHE LEU THR GLN TYR PHE LEU HIS GLN GLN PRO          
SEQRES  23 S  394  ALA ASN CYS LYS VAL GLU SER LEU ALA MET PHE LEU GLY          
SEQRES  24 S  394  GLU LEU SER LEU ILE ASP ALA ASP PRO TYR LEU LYS TYR          
SEQRES  25 S  394  LEU PRO SER VAL ILE ALA GLY ALA ALA PHE HIS LEU ALA          
SEQRES  26 S  394  LEU TYR THR VAL THR GLY GLN SER TRP PRO GLU SER LEU          
SEQRES  27 S  394  ILE ARG LYS THR GLY TYR THR LEU GLU SER LEU LYS PRO          
SEQRES  28 S  394  CYS LEU MET ASP LEU HIS GLN THR TYR LEU LYS ALA PRO          
SEQRES  29 S  394  GLN HIS ALA GLN GLN SER ILE ARG GLU LYS TYR LYS ASN          
SEQRES  30 S  394  SER LYS TYR HIS GLY VAL SER LEU LEU ASN PRO PRO GLU          
SEQRES  31 S  394  THR LEU ASN LEU                                              
HELIX    1 AA1 ASP L   12  THR L   19  1                                   8    
HELIX    2 AA2 GLY L   41  ARG L   46  5                                   6    
HELIX    3 AA3 ASN L  101  LEU L  105  5                                   5    
HELIX    4 AA4 GLN L  146  GLY L  148  5                                   3    
HELIX    5 AA5 THR L  175  MET L  180  1                                   6    
HELIX    6 AA6 VAL D   25  GLU D   46  1                                  22    
HELIX    7 AA7 GLY A   24  LYS A   29  1                                   6    
HELIX    8 AA8 SER A  143  ASN A  145  5                                   3    
HELIX    9 AA9 GLU A  616  LEU A  629  1                                  14    
HELIX   10 AB1 PRO A  630  SER A  646  1                                  17    
HELIX   11 AB2 SER A  655  MET A  668  1                                  14    
HELIX   12 AB3 ASP A  704  ASN A  712  1                                   9    
HELIX   13 AB4 SER A  713  HIS A  722  1                                  10    
HELIX   14 AB5 LEU A  755  THR A  757  5                                   3    
HELIX   15 AB6 HIS A  758  LYS A  774  1                                  17    
HELIX   16 AB7 ASN A  776  GLY A  780  5                                   5    
HELIX   17 AB8 GLY A  782  ARG A  795  1                                  14    
HELIX   18 AB9 LEU A  799  ARG A  808  1                                  10    
HELIX   19 AC1 SER A  843  SER A  850  1                                   8    
HELIX   20 AC2 CYS A  867  ILE A  881  1                                  15    
HELIX   21 AC3 LEU A  926  GLY A  938  1                                  13    
HELIX   22 AC4 THR A  940  GLU A  945  1                                   6    
HELIX   23 AC5 PRO A  948  GLU A  964  1                                  17    
HELIX   24 AC6 VAL A  974  GLY A  979  1                                   6    
HELIX   25 AC7 ARG A  980  SER A  984  5                                   5    
HELIX   26 AC8 ASN A 1020  TRP A 1028  1                                   9    
HELIX   27 AC9 LEU A 1032  LEU A 1041  1                                  10    
HELIX   28 AD1 SER A 1058  MET A 1078  1                                  21    
HELIX   29 AD2 ALA A 1079  THR A 1088  1                                  10    
HELIX   30 AD3 THR A 1132  LEU A 1145  1                                  14    
HELIX   31 AD4 ASP A 1154  TYR A 1160  1                                   7    
HELIX   32 AD5 LEU A 1168  ASN A 1182  1                                  15    
HELIX   33 AD6 HIS A 1184  LEU A 1188  5                                   5    
HELIX   34 AD7 ALA A 1189  THR A 1198  1                                  10    
HELIX   35 AD8 HIS A 1201  ALA A 1215  1                                  15    
HELIX   36 AD9 ASP A 1221  ILE A 1230  1                                  10    
HELIX   37 AE1 PRO A 1246  TYR A 1261  1                                  16    
HELIX   38 AE2 HIS A 1266  GLY A 1278  1                                  13    
HELIX   39 AE3 ASP A 1290  LEU A 1307  1                                  18    
HELIX   40 AE4 ASN A 1320  GLY A 1331  1                                  12    
HELIX   41 AE5 ASN A 1359  TYR A 1375  1                                  17    
HELIX   42 AE6 THR A 1392  ASP A 1397  1                                   6    
HELIX   43 AE7 LYS A 1400  LEU A 1415  1                                  16    
HELIX   44 AE8 ASN A 1422  SER A 1428  1                                   7    
HELIX   45 AE9 PRO A 1431  ASN A 1437  1                                   7    
HELIX   46 AF1 LEU A 1454  PHE A 1476  1                                  23    
HELIX   47 AF2 ASN A 1481  SER A 1500  1                                  20    
HELIX   48 AF3 ASN A 1503  GLY A 1508  1                                   6    
HELIX   49 AF4 GLY A 1508  MET A 1527  1                                  20    
HELIX   50 AF5 ASN A 1532  MET A 1544  1                                  13    
HELIX   51 AF6 ASN A 1551  PHE A 1566  1                                  16    
HELIX   52 AF7 LEU A 1567  GLY A 1570  5                                   4    
HELIX   53 AF8 SER A 1577  LEU A 1588  1                                  12    
HELIX   54 AF9 LEU A 1603  LEU A 1612  5                                  10    
HELIX   55 AG1 GLY A 1683  LYS A 1693  1                                  11    
HELIX   56 AG2 ARG A 1726  ALA A 1732  1                                   7    
HELIX   57 AG3 GLU A 1736  PHE A 1741  5                                   6    
HELIX   58 AG4 ASP A 1744  PHE A 1754  1                                  11    
HELIX   59 AG5 LYS A 1764  GLN A 1781  1                                  18    
HELIX   60 AG6 MET A 1786  LEU A 1800  1                                  15    
HELIX   61 AG7 THR A 1808  GLU A 1819  1                                  12    
HELIX   62 AG8 SER A 1823  ARG A 1829  5                                   7    
HELIX   63 AG9 PHE A 1844  GLY A 1863  1                                  20    
HELIX   64 AH1 GLY A 1864  GLY A 1874  1                                  11    
HELIX   65 AH2 GLN A 1881  HIS A 1892  1                                  12    
HELIX   66 AH3 PHE A 1911  GLN A 1920  1                                  10    
HELIX   67 AH4 PRO A 1924  ALA A 1932  1                                   9    
HELIX   68 AH5 GLY N   17  THR N   29  1                                  13    
HELIX   69 AH6 GLU N   52  HIS N   65  1                                  14    
HELIX   70 AH7 SER N   69  ASN N   86  1                                  18    
HELIX   71 AH8 ASN N   86  SER N  101  1                                  16    
HELIX   72 AH9 ASP N  103  LEU N  138  1                                  36    
HELIX   73 AI1 GLY N  148  PHE N  162  1                                  15    
HELIX   74 AI2 PRO N  166  GLY N  193  1                                  28    
HELIX   75 AI3 TYR N  207  LEU N  215  1                                   9    
HELIX   76 AI4 LEU N  216  SER N  218  5                                   3    
HELIX   77 AI5 GLN N  235  LEU N  250  1                                  16    
HELIX   78 AI6 LEU N  252  SER N  257  1                                   6    
HELIX   79 AI7 GLU N  259  ARG N  278  1                                  20    
HELIX   80 AI8 PHE N  285  PHE N  304  1                                  20    
HELIX   81 AI9 PRO N  315  GLU N  343  1                                  29    
HELIX   82 AJ1 GLU N  343  ARG N  349  1                                   7    
HELIX   83 AJ2 ARG N  355  GLU N  366  1                                  12    
HELIX   84 AJ3 GLN N  370  LEU N  386  1                                  17    
HELIX   85 AJ4 ASN N  392  ASP N  411  1                                  20    
HELIX   86 AJ5 MET N  414  CYS N  421  1                                   8    
HELIX   87 AJ6 CYS N  421  THR N  430  1                                  10    
HELIX   88 AJ7 ASP N  433  ASP N  445  1                                  13    
HELIX   89 AJ8 ASP N  500  SER N  507  1                                   8    
HELIX   90 AJ9 LYS N  512  LEU N  528  1                                  17    
HELIX   91 AK1 ARG N  537  LEU N  544  1                                   8    
HELIX   92 AK2 LEU N  545  GLY N  550  1                                   6    
HELIX   93 AK3 GLU N  551  PRO N  553  5                                   3    
HELIX   94 AK4 MET N  554  ARG N  575  1                                  22    
HELIX   95 AK5 PRO N  612  LYS N  630  1                                  19    
HELIX   96 AK6 THR N  660  TYR N  669  1                                  10    
HELIX   97 AK7 THR N  677  VAL N  685  1                                   9    
HELIX   98 AK8 ARG N  693  GLN N  701  5                                   9    
HELIX   99 AK9 THR I  119  VAL I  124  5                                   6    
HELIX  100 AL1 ASP I  162  ASP I  170  1                                   9    
HELIX  101 AL2 ASN I  239  PHE I  244  1                                   6    
HELIX  102 AL3 PHE I  244  ALA I  275  1                                  32    
HELIX  103 AL4 MET I  281  GLU I  293  1                                  13    
HELIX  104 AL5 SER I  299  GLY I  311  1                                  13    
HELIX  105 AL6 SER I  314  ASN I  323  1                                  10    
HELIX  106 AL7 LYS I  328  SER I  350  1                                  23    
HELIX  107 AL8 HIS I  351  TRP I  372  1                                  22    
HELIX  108 AL9 ASP I  382  ARG I  427  1                                  46    
HELIX  109 AM1 THR I  441  PHE I  456  1                                  16    
HELIX  110 AM2 VAL I  475  LYS I  480  1                                   6    
HELIX  111 AM3 ASN I  495  ASN I  503  1                                   9    
HELIX  112 AM4 SER I  521  LYS I  546  1                                  26    
HELIX  113 AM5 THR I  560  ASP I  564  5                                   5    
HELIX  114 AM6 LEU I  671  TYR I  675  1                                   5    
HELIX  115 AM7 ASN I  676  ALA I  681  1                                   6    
HELIX  116 AM8 THR O   31  SER O   45  1                                  15    
HELIX  117 AM9 SER O   53  GLY O   70  1                                  18    
HELIX  118 AN1 THR O   74  CYS O   86  1                                  13    
HELIX  119 AN2 PRO O   87  GLY O  103  1                                  17    
HELIX  120 AN3 GLU O  104  SER O  116  1                                  13    
HELIX  121 AN4 ASP O  117  PHE O  119  5                                   3    
HELIX  122 AN5 SER O  130  LYS O  145  1                                  16    
HELIX  123 AN6 SER O  147  THR O  169  1                                  23    
HELIX  124 AN7 GLN O  209  ASP O  226  1                                  18    
HELIX  125 AN8 THR O  232  ASN O  247  1                                  16    
HELIX  126 AN9 ALA O  251  ARG O  263  1                                  13    
HELIX  127 AO1 ASP O  266  LEU O  281  1                                  16    
HELIX  128 AO2 SER O  299  GLY O  315  1                                  17    
HELIX  129 AO3 HIS O  316  SER O  334  1                                  19    
HELIX  130 AO4 HIS O  337  GLY O  351  1                                  15    
HELIX  131 AO5 ASP O  356  HIS O  370  1                                  15    
HELIX  132 AO6 LEU O  373  ALA O  391  1                                  19    
HELIX  133 AO7 THR O  394  SER O  413  1                                  20    
HELIX  134 AO8 SER O  415  TYR O  432  1                                  18    
HELIX  135 AO9 ARG O  434  SER O  447  1                                  14    
HELIX  136 AP1 THR O  463  GLN O  480  1                                  18    
HELIX  137 AP2 CYS O  482  PHE O  497  1                                  16    
HELIX  138 AP3 ALA O  504  GLY O  523  1                                  20    
HELIX  139 AP4 LYS O  524  ASN O  539  1                                  16    
HELIX  140 AP5 ASN O  539  GLN O  554  1                                  16    
HELIX  141 AP6 GLN O  556  LYS O  575  1                                  20    
HELIX  142 AP7 ASN O  576  TRP O  592  1                                  17    
HELIX  143 AP8 SER O  596  ILE O  599  5                                   4    
HELIX  144 AP9 ALA O  600  TYR O  614  1                                  15    
HELIX  145 AQ1 LEU O  616  LEU O  634  1                                  19    
HELIX  146 AQ2 ILE O  636  ALA O  647  1                                  12    
HELIX  147 AQ3 ILE O  648  ASP O  654  1                                   7    
HELIX  148 AQ4 ALA O  656  SER O  674  1                                  19    
HELIX  149 AQ5 ASP O  679  ASP O  705  1                                  27    
HELIX  150 AQ6 CYS O  706  GLY O  725  1                                  20    
HELIX  151 AQ7 LYS O  726  GLN O  742  1                                  17    
HELIX  152 AQ8 LEU K    3  GLN K   16  1                                  14    
HELIX  153 AQ9 GLN K   18  SER K   33  1                                  16    
HELIX  154 AR1 GLU K   36  THR K   50  1                                  15    
HELIX  155 AR2 GLN K   52  SER K   62  1                                  11    
HELIX  156 AR3 TYR K   69  ALA K   83  1                                  15    
HELIX  157 AR4 GLU K   85  ASP K   94  1                                  10    
HELIX  158 AR5 ILE K  128  LEU K  143  1                                  16    
HELIX  159 AR6 ASN K  145  ASP K  160  1                                  16    
HELIX  160 AR7 CYS K  163  THR K  171  1                                   9    
HELIX  161 AR8 THR K  177  LEU K  188  1                                  12    
HELIX  162 AR9 CYS K  194  LYS K  210  1                                  17    
HELIX  163 AS1 ASP K  225  ASN K  230  5                                   6    
HELIX  164 AS2 VAL K  233  ASN K  244  1                                  12    
HELIX  165 AS3 ASP K  246  ASP K  261  1                                  16    
HELIX  166 AS4 SER K  266  VAL K  276  1                                  11    
HELIX  167 AS5 LYS K  280  TYR K  295  1                                  16    
HELIX  168 AS6 ASN K  298  GLY K  313  1                                  16    
HELIX  169 AS7 LYS K  315  GLU K  330  1                                  16    
HELIX  170 AS8 TYR K  333  VAL K  346  1                                  14    
HELIX  171 AS9 GLU K  349  MET K  364  1                                  16    
HELIX  172 AT1 HIS K  368  LEU K  380  1                                  13    
HELIX  173 AT2 ASN K  383  ALA K  398  1                                  16    
HELIX  174 AT3 ASP K  401  GLN K  414  1                                  14    
HELIX  175 AT4 GLU K  417  GLY K  436  1                                  20    
HELIX  176 AT5 TRP K  444  LEU K  458  1                                  15    
HELIX  177 AT6 LYS K  460  ILE K  475  1                                  16    
HELIX  178 AT7 ASN K  478  MET K  492  1                                  15    
HELIX  179 AT8 ASN K  494  ARG K  509  1                                  16    
HELIX  180 AT9 ASP K  512  GLY K  528  1                                  17    
HELIX  181 AU1 THR K  554  SER K  560  1                                   7    
HELIX  182 AU2 CYS C   34  LYS C   38  5                                   5    
HELIX  183 AU3 MET C   57  ALA C   66  1                                  10    
HELIX  184 AU4 LYS G   12  ASP G   14  5                                   3    
HELIX  185 AU5 ASP G   15  GLU G   27  1                                  13    
HELIX  186 AU6 LYS W   12  ASP W   14  5                                   3    
HELIX  187 AU7 ASP W   15  ASP W   25  1                                  11    
HELIX  188 AU8 ARG M   10  ILE M   15  1                                   6    
HELIX  189 AU9 ASP M   16  GLU M   21  1                                   6    
HELIX  190 AV1 LYS M   51  LYS M   56  5                                   6    
HELIX  191 AV2 ARG H   52  ASP H   92  1                                  41    
HELIX  192 AV3 GLU H   93  PHE H   96  5                                   4    
HELIX  193 AV4 PRO H   98  LEU H  103  1                                   6    
HELIX  194 AV5 GLU J    6  HIS J   18  1                                  13    
HELIX  195 AV6 ALA J   20  VAL J   35  1                                  16    
HELIX  196 AV7 SER J   37  SER J   51  1                                  15    
HELIX  197 AV8 LYS J   53  GLY J   63  1                                  11    
HELIX  198 AV9 THR J   68  LEU J   82  1                                  15    
HELIX  199 AW1 LYS J   84  SER J   93  1                                  10    
HELIX  200 AW2 SER J  102  GLY J  111  1                                  10    
HELIX  201 AW3 SER J  113  THR J  128  1                                  16    
HELIX  202 AW4 ARG J  130  ASN J  145  1                                  16    
HELIX  203 AW5 LEU J  148  ILE J  158  1                                  11    
HELIX  204 AW6 ASP J  163  PHE J  168  1                                   6    
HELIX  205 AW7 PHE J  452  SER J  478  1                                  27    
HELIX  206 AW8 ASN J  480  HIS J  490  1                                  11    
HELIX  207 AW9 PRO J  492  ASN J  497  1                                   6    
HELIX  208 AX1 THR J  498  LEU J  512  1                                  15    
HELIX  209 AX2 GLU J  514  GLU J  529  1                                  16    
HELIX  210 AX3 GLY J  535  GLN J  547  1                                  13    
HELIX  211 AX4 LYS J  548  ASP J  563  1                                  16    
HELIX  212 AX5 SER J  566  GLN J  580  1                                  15    
HELIX  213 AX6 GLU J  582  ASP J  597  1                                  16    
HELIX  214 AX7 TYR J  600  THR J  614  1                                  15    
HELIX  215 AX8 GLU J  616  ASN J  631  1                                  16    
HELIX  216 AX9 HIS J  634  GLN J  648  1                                  15    
HELIX  217 AY1 LYS J  650  ASN J  665  1                                  16    
HELIX  218 AY2 SER J  668  LEU J  682  1                                  15    
HELIX  219 AY3 LYS J  684  ASP J  699  1                                  16    
HELIX  220 AY4 ASN J  702  ASN J  716  1                                  15    
HELIX  221 AY5 LYS J  718  GLN J  731  1                                  14    
HELIX  222 AY6 GLU J  736  LEU J  750  1                                  15    
HELIX  223 AY7 GLN J  752  LEU J  766  1                                  15    
HELIX  224 AY8 ALA J  771  ASP J  780  1                                  10    
HELIX  225 AY9 GLU P    6  HIS P   18  1                                  13    
HELIX  226 AZ1 ALA P   20  VAL P   35  1                                  16    
HELIX  227 AZ2 SER P   37  SER P   51  1                                  15    
HELIX  228 AZ3 LYS P   53  GLY P   63  1                                  11    
HELIX  229 AZ4 THR P   68  LEU P   82  1                                  15    
HELIX  230 AZ5 LYS P   84  SER P   93  1                                  10    
HELIX  231 AZ6 SER P  102  GLY P  111  1                                  10    
HELIX  232 AZ7 SER P  113  THR P  128  1                                  16    
HELIX  233 AZ8 ARG P  130  ASN P  145  1                                  16    
HELIX  234 AZ9 TRP P  149  GLY P  159  1                                  11    
HELIX  235 BA1 ASP P  163  PHE P  168  1                                   6    
HELIX  236 BA2 ASN P  453  SER P  478  1                                  26    
HELIX  237 BA3 ASN P  480  SER P  489  1                                  10    
HELIX  238 BA4 PRO P  492  ASN P  497  1                                   6    
HELIX  239 BA5 THR P  498  LEU P  512  1                                  15    
HELIX  240 BA6 GLU P  514  GLU P  529  1                                  16    
HELIX  241 BA7 GLY P  535  LEU P  546  1                                  12    
HELIX  242 BA8 LYS P  548  ASP P  561  1                                  14    
HELIX  243 BA9 SER P  566  GLN P  580  1                                  15    
HELIX  244 BB1 GLU P  582  ASP P  597  1                                  16    
HELIX  245 BB2 TYR P  600  THR P  614  1                                  15    
HELIX  246 BB3 GLU P  616  ASN P  631  1                                  16    
HELIX  247 BB4 HIS P  634  GLN P  648  1                                  15    
HELIX  248 BB5 LYS P  650  ASN P  665  1                                  16    
HELIX  249 BB6 SER P  668  LEU P  682  1                                  15    
HELIX  250 BB7 LYS P  684  ASP P  699  1                                  16    
HELIX  251 BB8 ASN P  702  ASN P  716  1                                  15    
HELIX  252 BB9 LYS P  718  GLN P  731  1                                  14    
HELIX  253 BC1 SER P  737  LEU P  750  1                                  14    
HELIX  254 BC2 GLN P  752  ASP P  767  1                                  16    
HELIX  255 BC3 LEU Q    3  GLN Q   16  1                                  14    
HELIX  256 BC4 GLN Q   18  SER Q   33  1                                  16    
HELIX  257 BC5 GLU Q   36  THR Q   50  1                                  15    
HELIX  258 BC6 GLN Q   52  SER Q   62  1                                  11    
HELIX  259 BC7 LYS Q   64  TYR Q   69  1                                   6    
HELIX  260 BC8 TYR Q   69  ALA Q   83  1                                  15    
HELIX  261 BC9 GLU Q   85  ASP Q   94  1                                  10    
HELIX  262 BD1 GLN Q  125  LEU Q  143  1                                  19    
HELIX  263 BD2 ASN Q  145  ASP Q  160  1                                  16    
HELIX  264 BD3 CYS Q  163  SER Q  172  1                                  10    
HELIX  265 BD4 THR Q  177  LEU Q  188  1                                  12    
HELIX  266 BD5 ASN Q  195  ASN Q  207  1                                  13    
HELIX  267 BD6 ASN Q  230  ASN Q  244  1                                  15    
HELIX  268 BD7 ASP Q  246  LYS Q  252  1                                   7    
HELIX  269 BD8 VAL Q  256  ASP Q  261  1                                   6    
HELIX  270 BD9 SER Q  266  LEU Q  278  1                                  13    
HELIX  271 BE1 LYS Q  280  TYR Q  295  1                                  16    
HELIX  272 BE2 ASN Q  298  GLY Q  313  1                                  16    
HELIX  273 BE3 LYS Q  315  GLU Q  330  1                                  16    
HELIX  274 BE4 TYR Q  333  VAL Q  346  1                                  14    
HELIX  275 BE5 GLU Q  349  MET Q  364  1                                  16    
HELIX  276 BE6 HIS Q  368  THR Q  381  1                                  14    
HELIX  277 BE7 ASN Q  383  ALA Q  398  1                                  16    
HELIX  278 BE8 ASP Q  401  GLY Q  416  1                                  16    
HELIX  279 BE9 GLU Q  417  LYS Q  433  1                                  17    
HELIX  280 BF1 TRP Q  444  LEU Q  458  1                                  15    
HELIX  281 BF2 LYS Q  460  ILE Q  475  1                                  16    
HELIX  282 BF3 ASN Q  478  GLY Q  493  1                                  16    
HELIX  283 BF4 ASN Q  494  ARG Q  510  1                                  17    
HELIX  284 BF5 THR Q  513  GLY Q  528  1                                  16    
HELIX  285 BF6 VAL Y   37  GLY Y   48  1                                  12    
HELIX  286 BF7 SER Y   51  ASN Y   67  1                                  17    
HELIX  287 BF8 SER Y   72  HIS Y   89  1                                  18    
HELIX  288 BF9 GLU Y   92  ALA Y  109  1                                  18    
HELIX  289 BG1 SER Y  134  LEU Y  149  1                                  16    
HELIX  290 BG2 GLN Y  151  ILE Y  162  1                                  12    
HELIX  291 BG3 PRO Y  163  ARG Y  167  5                                   5    
HELIX  292 BG4 THR Y  168  ALA Y  182  1                                  15    
HELIX  293 BG5 GLN Y  184  CYS Y  199  1                                  16    
HELIX  294 BG6 ALA Y  202  LEU Y  212  1                                  11    
HELIX  295 BG7 LYS Y  215  THR Y  223  1                                   9    
HELIX  296 BG8 THR Y  223  GLN Y  228  1                                   6    
HELIX  297 BG9 TRP Y  235  HIS Y  247  1                                  13    
HELIX  298 BH1 ASP Y  250  SER Y  265  1                                  16    
HELIX  299 BH2 ASN Y  270  GLY Y  285  1                                  16    
HELIX  300 BH3 SER Y  290  ASP Y  301  1                                  12    
HELIX  301 BH4 GLY Y  307  GLU Y  318  1                                  12    
HELIX  302 BH5 ARG Y  320  ASN Y  333  1                                  14    
HELIX  303 BH6 ALA Y  339  SER Y  352  1                                  14    
HELIX  304 BH7 ARG Y  354  ASN Y  369  1                                  16    
HELIX  305 BH8 SER Y  372  GLY Y  387  1                                  16    
HELIX  306 BH9 ARG Y  388  ALA Y  403  1                                  16    
HELIX  307 BI1 ARG Y  406  SER Y  420  1                                  15    
HELIX  308 BI2 SER Y  422  LEU Y  437  1                                  16    
HELIX  309 BI3 ASN Y  440  VAL Y  450  1                                  11    
HELIX  310 BI4 CYS Y  451  GLU Y  453  5                                   3    
HELIX  311 BI5 ASP Y  454  VAL Y  456  5                                   3    
HELIX  312 BI6 THR Y  457  ARG Y  472  1                                  16    
HELIX  313 BI7 TYR Y  475  GLN Y  490  1                                  16    
HELIX  314 BI8 LYS Y  491  ALA Y  504  1                                  14    
HELIX  315 BI9 ASP Y  508  ASN Y  523  1                                  16    
HELIX  316 BJ1 GLU Y  524  ASP Y  539  1                                  16    
HELIX  317 BJ2 ASP Y  542  LYS Y  554  1                                  13    
HELIX  318 BJ3 LEU U   29  ARG U   46  1                                  18    
HELIX  319 BJ4 LEU U   48  LEU U   62  1                                  15    
HELIX  320 BJ5 THR U   77  GLN U   82  1                                   6    
HELIX  321 BJ6 ASP U   83  VAL U   96  1                                  14    
HELIX  322 BJ7 GLU U   98  LEU U  106  1                                   9    
HELIX  323 BJ8 SER U  111  THR U  134  1                                  24    
HELIX  324 BJ9 ASN U  148  ALA U  164  1                                  17    
HELIX  325 BK1 GLY U  169  LEU U  182  1                                  14    
HELIX  326 BK2 LEU U  184  LEU U  199  1                                  16    
HELIX  327 BK3 HIS U  202  ASN U  211  1                                  10    
HELIX  328 BK4 ASP U  215  LEU U  222  1                                   8    
HELIX  329 BK5 TRP U  228  LEU U  241  1                                  14    
HELIX  330 BK6 LEU U  243  GLY U  258  1                                  16    
HELIX  331 BK7 SER U  262  ILE U  276  1                                  15    
HELIX  332 BK8 ASP U  278  ASP U  293  1                                  16    
HELIX  333 BK9 ASN U  299  VAL U  309  1                                  11    
HELIX  334 BL1 MET U  312  ASP U  327  1                                  16    
HELIX  335 BL2 ARG U  330  ARG U  344  1                                  15    
HELIX  336 BL3 GLN U  346  ASN U  361  1                                  16    
HELIX  337 BL4 ALA U  367  MET U  378  1                                  12    
HELIX  338 BL5 ASN U  380  ASN U  395  1                                  16    
HELIX  339 BL6 ASP U  398  LEU U  412  1                                  15    
HELIX  340 BL7 MET U  414  ARG U  429  1                                  16    
HELIX  341 BL8 ASP U  432  LEU U  446  1                                  15    
HELIX  342 BL9 GLN U  448  VAL U  462  1                                  15    
HELIX  343 BM1 MET U  468  LEU U  480  1                                  13    
HELIX  344 BM2 SER U  483  CYS U  500  1                                  18    
HELIX  345 BM3 SER U  510  ALA U  517  1                                   8    
HELIX  346 BM4 GLN U  518  CYS U  523  1                                   6    
HELIX  347 BM5 TRP U  526  CYS U  536  1                                  11    
HELIX  348 BM6 THR U  542  ILE U  553  1                                  12    
HELIX  349 BM7 ASP V   28  ARG V   46  1                                  19    
HELIX  350 BM8 LEU V   48  LEU V   62  1                                  15    
HELIX  351 BM9 THR V   77  ASP V   83  1                                   7    
HELIX  352 BN1 ASP V   83  VAL V   96  1                                  14    
HELIX  353 BN2 GLU V   98  PHE V  105  1                                   8    
HELIX  354 BN3 SER V  111  VAL V  135  1                                  25    
HELIX  355 BN4 LEU V  151  ALA V  164  1                                  14    
HELIX  356 BN5 ASP V  168  LEU V  182  1                                  15    
HELIX  357 BN6 LEU V  184  LEU V  199  1                                  16    
HELIX  358 BN7 HIS V  202  CYS V  210  1                                   9    
HELIX  359 BN8 ASP V  215  LEU V  222  1                                   8    
HELIX  360 BN9 TRP V  228  THR V  239  1                                  12    
HELIX  361 BO1 LEU V  243  VAL V  257  1                                  15    
HELIX  362 BO2 SER V  262  ILE V  276  1                                  15    
HELIX  363 BO3 ASP V  278  ASP V  293  1                                  16    
HELIX  364 BO4 ASN V  299  SER V  311  1                                  13    
HELIX  365 BO5 MET V  312  GLU V  325  1                                  14    
HELIX  366 BO6 ARG V  330  ARG V  344  1                                  15    
HELIX  367 BO7 GLN V  346  ASN V  361  1                                  16    
HELIX  368 BO8 LEU V  365  MET V  378  1                                  14    
HELIX  369 BO9 ASN V  380  ASN V  395  1                                  16    
HELIX  370 BP1 ASP V  398  LEU V  412  1                                  15    
HELIX  371 BP2 CYS V  418  ARG V  429  1                                  12    
HELIX  372 BP3 ASP V  432  LYS V  445  1                                  14    
HELIX  373 BP4 GLN V  448  VAL V  462  1                                  15    
HELIX  374 BP5 MET V  468  LEU V  480  1                                  13    
HELIX  375 BP6 GLU V  482  CYS V  500  1                                  19    
HELIX  376 BP7 GLU V  508  CYS V  523  1                                  16    
HELIX  377 BP8 LEU V  525  GLN V  534  1                                  10    
HELIX  378 BP9 LYS V  535  PHE V  539  5                                   5    
HELIX  379 BQ1 THR V  542  LEU V  556  1                                  15    
HELIX  380 BQ2 VAL Z   37  ALA Z   47  1                                  11    
HELIX  381 BQ3 HIS Z   50  ASN Z   67  1                                  18    
HELIX  382 BQ4 SER Z   72  ASP Z   90  1                                  19    
HELIX  383 BQ5 GLU Z   92  SER Z  111  1                                  20    
HELIX  384 BQ6 SER Z  134  LEU Z  149  1                                  16    
HELIX  385 BQ7 GLN Z  151  ASP Z  160  1                                  10    
HELIX  386 BQ8 THR Z  168  GLY Z  183  1                                  16    
HELIX  387 BQ9 GLN Z  184  CYS Z  199  1                                  16    
HELIX  388 BR1 ALA Z  202  LEU Z  212  1                                  11    
HELIX  389 BR2 LYS Z  215  THR Z  223  1                                   9    
HELIX  390 BR3 ASN Z  225  THR Z  229  5                                   5    
HELIX  391 BR4 TRP Z  235  GLY Z  249  1                                  15    
HELIX  392 BR5 ASP Z  250  LYS Z  263  1                                  14    
HELIX  393 BR6 ASN Z  270  ALA Z  284  1                                  15    
HELIX  394 BR7 ASP Z  286  ASP Z  301  1                                  16    
HELIX  395 BR8 GLY Z  307  GLY Z  319  1                                  13    
HELIX  396 BR9 ARG Z  320  ILE Z  334  1                                  15    
HELIX  397 BS1 HIS Z  338  TYR Z  351  1                                  14    
HELIX  398 BS2 ARG Z  354  ASN Z  369  1                                  16    
HELIX  399 BS3 SER Z  372  MET Z  386  1                                  15    
HELIX  400 BS4 ALA Z  392  ALA Z  403  1                                  12    
HELIX  401 BS5 ARG Z  406  SER Z  420  1                                  15    
HELIX  402 BS6 ILE Z  423  GLY Z  438  1                                  16    
HELIX  403 BS7 ASN Z  440  GLU Z  453  1                                  14    
HELIX  404 BS8 ASP Z  454  GLN Z  458  5                                   5    
HELIX  405 BS9 GLU Z  459  ARG Z  472  1                                  14    
HELIX  406 BT1 TYR Z  475  GLU Z  489  1                                  15    
HELIX  407 BT2 TYR Z  492  SER Z  507  1                                  16    
HELIX  408 BT3 ARG Z  513  VAL Z  522  1                                  10    
HELIX  409 BT4 GLU Z  527  ASP Z  539  1                                  13    
HELIX  410 BT5 SER R   84  GLN R  100  1                                  17    
HELIX  411 BT6 THR R  106  ASN R  121  1                                  16    
SHEET    1 AA1 4 VAL L  22  GLU L  24  0                                        
SHEET    2 AA1 4 ILE L 156  PRO L 161 -1  O  THR L 160   N  ARG L  23           
SHEET    3 AA1 4 THR L  76  ASP L  82 -1  N  CYS L  78   O  LYS L 157           
SHEET    4 AA1 4 SER L 117  PRO L 123 -1  O  VAL L 122   N  LEU L  77           
SHEET    1 AA2 6 GLN L 106  GLU L 112  0                                        
SHEET    2 AA2 6 PRO L  91  GLY L  99 -1  N  ILE L  94   O  LEU L 111           
SHEET    3 AA2 6 THR L 132  ASN L 144 -1  O  GLN L 138   N  ARG L  97           
SHEET    4 AA2 6 HIS L  62  VAL L  74 -1  N  ILE L  66   O  ILE L 137           
SHEET    5 AA2 6 ALA L  29  LEU L  33 -1  N  SER L  32   O  ASN L  65           
SHEET    6 AA2 6 ILE A1352  LYS A1353 -1  O  LYS A1353   N  TRP L  31           
SHEET    1 AA3 2 TRP L  54  GLN L  55  0                                        
SHEET    2 AA3 2 HIS L 152  MET L 153 -1  O  MET L 153   N  TRP L  54           
SHEET    1 AA4 5 ILE A  12  ALA A  13  0                                        
SHEET    2 AA4 5 ARG A 505  PHE A 510  1  O  LYS A 508   N  ILE A  12           
SHEET    3 AA4 5 LEU A 497  TYR A 500 -1  N  LEU A 499   O  GLY A 507           
SHEET    4 AA4 5 THR A 487  LEU A 491 -1  N  MET A 488   O  TYR A 500           
SHEET    5 AA4 5 ASP A 478  VAL A 482 -1  N  VAL A 482   O  THR A 487           
SHEET    1 AA5 4 GLN A  18  GLU A  19  0                                        
SHEET    2 AA5 4 MET A 604  THR A 608 -1  O  ARG A 606   N  GLN A  18           
SHEET    3 AA5 4 ARG A 594  LEU A 599 -1  N  VAL A 595   O  ILE A 607           
SHEET    4 AA5 4 ILE A 584  VAL A 591 -1  N  HIS A 585   O  GLU A 598           
SHEET    1 AA6 4 LEU A  76  LYS A  78  0                                        
SHEET    2 AA6 4 ASP A  90  ALA A  96 -1  O  GLU A  91   N  ARG A  77           
SHEET    3 AA6 4 MET A  99  SER A 103 -1  O  SER A 103   N  GLU A  92           
SHEET    4 AA6 4 VAL A 113  THR A 118 -1  O  LYS A 115   N  TRP A 102           
SHEET    1 AA7 4 GLN A 125  ILE A 132  0                                        
SHEET    2 AA7 4 VAL A 147  LEU A 154 -1  O  LEU A 154   N  GLN A 125           
SHEET    3 AA7 4 CYS A 158  SER A 163 -1  O  ASN A 160   N  ILE A 153           
SHEET    4 AA7 4 ASP A 168  SER A 172 -1  O  ALA A 171   N  ILE A 159           
SHEET    1 AA8 4 VAL A 177  PRO A 182  0                                        
SHEET    2 AA8 4 LEU A 187  ARG A 191 -1  O  GLU A 190   N  ASN A 179           
SHEET    3 AA8 4 MET A 210  MET A 213 -1  O  MET A 213   N  LEU A 187           
SHEET    4 AA8 4 THR A 221  PRO A 222 -1  O  THR A 221   N  SER A 212           
SHEET    1 AA9 6 GLN A 237  TYR A 238  0                                        
SHEET    2 AA9 6 VAL A 224  LYS A 226 -1  N  CYS A 225   O  GLN A 237           
SHEET    3 AA9 6 LEU A 407  THR A 414  1  O  ILE A 409   N  VAL A 224           
SHEET    4 AA9 6 VAL A 265  ARG A 273 -1  N  ARG A 272   O  CYS A 408           
SHEET    5 AA9 6 ILE A 255  ASP A 260 -1  N  VAL A 256   O  TRP A 269           
SHEET    6 AA9 6 MET A 244  LEU A 249 -1  N  VAL A 247   O  MET A 257           
SHEET    1 AB1 4 VAL A 430  SER A 434  0                                        
SHEET    2 AB1 4 LYS A 440  VAL A 446 -1  O  CYS A 443   N  PHE A 431           
SHEET    3 AB1 4 GLN A 451  GLU A 459 -1  O  VAL A 455   N  LEU A 442           
SHEET    4 AB1 4 LEU A 466  PHE A 468 -1  O  ILE A 467   N  GLN A 458           
SHEET    1 AB2 4 VAL A 430  SER A 434  0                                        
SHEET    2 AB2 4 LYS A 440  VAL A 446 -1  O  CYS A 443   N  PHE A 431           
SHEET    3 AB2 4 GLN A 451  GLU A 459 -1  O  VAL A 455   N  LEU A 442           
SHEET    4 AB2 4 ASN A 473  ILE A 474 -1  O  ILE A 474   N  LEU A 452           
SHEET    1 AB3 2 TYR A 860  TYR A 862  0                                        
SHEET    2 AB3 2 LEU A 896  ARG A 898  1  O  THR A 897   N  TYR A 860           
SHEET    1 AB4 3 VAL A1047  ARG A1048  0                                        
SHEET    2 AB4 3 GLY A1109  ALA A1111  1  O  ARG A1110   N  VAL A1047           
SHEET    3 AB4 3 THR A1116  VAL A1118 -1  O  THR A1116   N  ALA A1111           
SHEET    1 AB5 2 TYR A1572  LEU A1574  0                                        
SHEET    2 AB5 2 ALA A1614  PRO A1616 -1  O  GLU A1615   N  SER A1573           
SHEET    1 AB6 3 THR A1655  LEU A1656  0                                        
SHEET    2 AB6 3 LEU A1618  ASP A1623 -1  N  LEU A1619   O  THR A1655           
SHEET    3 AB6 3 VAL A1696  VAL A1699  1  O  LEU A1697   N  VAL A1622           
SHEET    1 AB7 4 THR A1647  MET A1652  0                                        
SHEET    2 AB7 4 LEU A1633  TYR A1638 -1  N  LEU A1634   O  LEU A1651           
SHEET    3 AB7 4 LEU A1663  LYS A1669 -1  O  LYS A1664   N  THR A1637           
SHEET    4 AB7 4 LEU A1676  ASP A1679 -1  O  LEU A1676   N  VAL A1668           
SHEET    1 AB8 2 GLY N 590  VAL N 591  0                                        
SHEET    2 AB8 2 CYS C   7  TRP C   8  1  O  TRP C   8   N  GLY N 590           
SHEET    1 AB9 2 LEU N 635  SER N 636  0                                        
SHEET    2 AB9 2 THR C  13  TRP C  14 -1  O  THR C  13   N  SER N 636           
SHEET    1 AC1 3 LEU N 655  SER N 656  0                                        
SHEET    2 AC1 3 ASP N 647  VAL N 648 -1  N  VAL N 648   O  LEU N 655           
SHEET    3 AC1 3 VAL C   3  LYS C   4 -1  O  LYS C   4   N  ASP N 647           
SHEET    1 AC2 4 ARG I  12  GLY I  15  0                                        
SHEET    2 AC2 4 VAL I 741  GLU I 745 -1  O  VAL I 743   N  GLY I  15           
SHEET    3 AC2 4 VAL I 730  SER I 735 -1  N  SER I 731   O  PHE I 744           
SHEET    4 AC2 4 ALA I 719  ASN I 725 -1  N  TYR I 721   O  LEU I 734           
SHEET    1 AC3 4 ILE I  23  TRP I  28  0                                        
SHEET    2 AC3 4 ILE I  35  ASN I  39 -1  O  ALA I  38   N  ILE I  24           
SHEET    3 AC3 4 VAL I  44  HIS I  47 -1  O  HIS I  47   N  ILE I  35           
SHEET    4 AC3 4 ARG I  54  PHE I  58 -1  O  PHE I  58   N  VAL I  44           
SHEET    1 AC4 4 VAL I  68  TRP I  73  0                                        
SHEET    2 AC4 4 LEU I  79  LEU I  84 -1  O  ALA I  81   N  ALA I  72           
SHEET    3 AC4 4 LYS I  89  ASP I  94 -1  O  VAL I  91   N  PHE I  82           
SHEET    4 AC4 4 HIS I 102  SER I 105 -1  O  HIS I 102   N  LEU I  92           
SHEET    1 AC5 4 VAL I 110  GLU I 117  0                                        
SHEET    2 AC5 4 ASN I 174  GLY I 180 -1  O  GLY I 179   N  SER I 111           
SHEET    3 AC5 4 ILE I 185  ALA I 189 -1  O  TYR I 188   N  LEU I 176           
SHEET    4 AC5 4 PHE I 193  VAL I 198 -1  O  PHE I 193   N  ALA I 189           
SHEET    1 AC6 4 THR I 204  LEU I 210  0                                        
SHEET    2 AC6 4 SER I 216  VAL I 223 -1  O  VAL I 220   N  ALA I 207           
SHEET    3 AC6 4 SER I 229  GLU I 237 -1  O  GLU I 230   N  VAL I 223           
SHEET    4 AC6 4 ILE I 554  ASP I 559 -1  O  ILE I 554   N  TYR I 233           
SHEET    1 AC7 5 PHE I 574  ASN I 578  0                                        
SHEET    2 AC7 5 LEU I 583  GLU I 592 -1  O  LEU I 587   N  PHE I 574           
SHEET    3 AC7 5 LEU I 595  HIS I 604 -1  O  ARG I 603   N  HIS I 584           
SHEET    4 AC7 5 LEU I 615  PHE I 623 -1  O  ILE I 616   N  ILE I 600           
SHEET    5 AC7 5 ARG I 632  ARG I 633 -1  O  ARG I 632   N  PHE I 623           
SHEET    1 AC8 5 PHE I 574  ASN I 578  0                                        
SHEET    2 AC8 5 LEU I 583  GLU I 592 -1  O  LEU I 587   N  PHE I 574           
SHEET    3 AC8 5 LEU I 595  HIS I 604 -1  O  ARG I 603   N  HIS I 584           
SHEET    4 AC8 5 LEU I 615  PHE I 623 -1  O  ILE I 616   N  ILE I 600           
SHEET    5 AC8 5 THR I 702  PHE I 707  1  O  ARG I 703   N  ALA I 617           
SHEET    1 AC9 4 TYR I 636  ASP I 645  0                                        
SHEET    2 AC9 4 THR I 648  ASP I 655 -1  O  LYS I 654   N  SER I 637           
SHEET    3 AC9 4 ARG I 664  PRO I 670 -1  O  LEU I 669   N  VAL I 649           
SHEET    4 AC9 4 TRP I 711  LEU I 713 -1  O  ARG I 712   N  LEU I 666           
SHEET    1 AD1 2 MET O  13  MET O  14  0                                        
SHEET    2 AD1 2 LEU V 138  GLY V 139 -1  N  GLY V 139   O  MET O  13           
SHEET    1 AD2 4 ARG R 174  ASP R 177  0                                        
SHEET    2 AD2 4 THR R 466  TRP R 470 -1  O  LEU R 467   N  LEU R 176           
SHEET    3 AD2 4 VAL R 458  ALA R 462 -1  N  SER R 460   O  ARG R 468           
SHEET    4 AD2 4 VAL R 446  MET R 451 -1  N  LEU R 447   O  ALA R 461           
SHEET    1 AD3 4 ASP R 191  TRP R 192  0                                        
SHEET    2 AD3 4 VAL R 197  LEU R 202 -1  O  ALA R 199   N  ASP R 191           
SHEET    3 AD3 4 SER R 205  SER R 210 -1  O  SER R 205   N  LEU R 202           
SHEET    4 AD3 4 ILE R 216  GLN R 221 -1  O  LEU R 217   N  LEU R 208           
SHEET    1 AD4 4 ILE R 229  TRP R 234  0                                        
SHEET    2 AD4 4 TYR R 240  THR R 245 -1  O  GLY R 244   N  SER R 231           
SHEET    3 AD4 4 VAL R 250  ASP R 254 -1  O  GLN R 251   N  VAL R 243           
SHEET    4 AD4 4 LYS R 259  MET R 264 -1  O  LYS R 259   N  ASP R 254           
SHEET    1 AD5 4 LEU R 274  TRP R 276  0                                        
SHEET    2 AD5 4 ILE R 280  GLY R 284 -1  O  SER R 282   N  SER R 275           
SHEET    3 AD5 4 HIS R 289  ASP R 294 -1  O  HIS R 291   N  SER R 283           
SHEET    4 AD5 4 LEU R 305  SER R 306 -1  O  LEU R 305   N  ILE R 290           
SHEET    1 AD6 4 VAL R 312  TRP R 317  0                                        
SHEET    2 AD6 4 HIS R 323  GLY R 328 -1  O  GLY R 327   N  GLY R 314           
SHEET    3 AD6 4 VAL R 333  PRO R 337 -1  O  TRP R 336   N  LEU R 324           
SHEET    4 AD6 4 GLN R 349  PHE R 351 -1  O  PHE R 351   N  VAL R 333           
SHEET    1 AD7 4 ALA R 360  TRP R 363  0                                        
SHEET    2 AD7 4 VAL R 370  GLY R 374 -1  O  ALA R 372   N  ALA R 362           
SHEET    3 AD7 4 HIS R 381  ASN R 386 -1  O  ARG R 383   N  THR R 373           
SHEET    4 AD7 4 CYS R 392  ASP R 397 -1  O  LEU R 393   N  ILE R 384           
SHEET    1 AD8 4 VAL R 402  SER R 408  0                                        
SHEET    2 AD8 4 GLU R 413  HIS R 418 -1  O  ILE R 415   N  LEU R 406           
SHEET    3 AD8 4 GLN R 424  TRP R 428 -1  O  GLN R 424   N  HIS R 418           
SHEET    4 AD8 4 ALA R 437  LYS R 440 -1  O  LEU R 439   N  LEU R 425           
CISPEP   1 GLN L   60    PRO L   61          0        -3.86                     
CISPEP   2 PRO A 1112    PRO A 1113          0        -1.27                     
CISPEP   3 PRO N  709    PRO N  710          0        -5.15                     
CISPEP   4 PHE I  572    PRO I  573          0         0.35                     
CISPEP   5 PHE R  420    ALA R  421          0        -0.24                     
CISPEP   6 TYR R  430    PRO R  431          0        -1.44                     
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1                      
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      1.000000  0.000000  0.000000        0.00000                         
SCALE2      0.000000  1.000000  0.000000        0.00000                         
SCALE3      0.000000  0.000000  1.000000        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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