HEADER ISOMERASE 30-APR-19 6RKU
TITLE E. COLI DNA GYRASE - DNA BINDING AND CLEAVAGE DOMAIN IN STATE 1
COMPND MOL_ID: 1;
COMPND 2 MOLECULE: DNA GYRASE SUBUNIT A;
COMPND 3 CHAIN: A, C;
COMPND 4 EC: 5.6.2.3;
COMPND 5 ENGINEERED: YES;
COMPND 6 OTHER_DETAILS: GYRA SUBUNIT DNA BINDING AND CLEAVAGE DOMAIN;
COMPND 7 MOL_ID: 2;
COMPND 8 MOLECULE: DNA GYRASE SUBUNIT B;
COMPND 9 CHAIN: B, D;
COMPND 10 SYNONYM: TYPE IIA TOPOISOMERASE SUBUNIT GYRB;
COMPND 11 EC: 5.6.2.3;
COMPND 12 ENGINEERED: YES;
COMPND 13 OTHER_DETAILS: GYRB SUBUNIT DNA BINDING AND CLEAVAGE DOMAIN;
COMPND 14 MOL_ID: 3;
COMPND 15 MOLECULE: DNA STRAND 1;
COMPND 16 CHAIN: F, E;
COMPND 17 ENGINEERED: YES;
COMPND 18 MOL_ID: 4;
COMPND 19 MOLECULE: DNA STRAND 2;
COMPND 20 CHAIN: G, H;
COMPND 21 ENGINEERED: YES
SOURCE MOL_ID: 1;
SOURCE 2 ORGANISM_SCIENTIFIC: ESCHERICHIA COLI (STRAIN K12);
SOURCE 3 ORGANISM_TAXID: 83333;
SOURCE 4 GENE: GYRA, HISW, NALA, PARD, B2231, JW2225;
SOURCE 5 EXPRESSION_SYSTEM: ESCHERICHIA COLI BL21(DE3);
SOURCE 6 EXPRESSION_SYSTEM_TAXID: 469008;
SOURCE 7 MOL_ID: 2;
SOURCE 8 ORGANISM_SCIENTIFIC: ESCHERICHIA COLI (STRAIN K12);
SOURCE 9 ORGANISM_TAXID: 83333;
SOURCE 10 GENE: GYRB, ACRB, COU, HIMB, HISU, NALC, PARA, PCBA, B3699, JW5625;
SOURCE 11 EXPRESSION_SYSTEM: ESCHERICHIA COLI BL21(DE3);
SOURCE 12 EXPRESSION_SYSTEM_TAXID: 469008;
SOURCE 13 MOL_ID: 3;
SOURCE 14 SYNTHETIC: YES;
SOURCE 15 ORGANISM_SCIENTIFIC: ESCHERICHIA COLI;
SOURCE 16 ORGANISM_TAXID: 562;
SOURCE 17 MOL_ID: 4;
SOURCE 18 SYNTHETIC: YES;
SOURCE 19 ORGANISM_SCIENTIFIC: ESCHERICHIA COLI;
SOURCE 20 ORGANISM_TAXID: 562
KEYWDS ISOMERASE, COMPLEX, DNA GYRASE, INHIBITOR, DNA BINDING PROTEIN
EXPDTA ELECTRON MICROSCOPY
AUTHOR A.VANDEN BROECK,V.LAMOUR
REVDAT 3 18-NOV-20 6RKU 1 REMARK
REVDAT 2 13-NOV-19 6RKU 1 JRNL
REVDAT 1 06-NOV-19 6RKU 0
JRNL AUTH A.VANDEN BROECK,C.LOTZ,J.ORTIZ,V.LAMOUR
JRNL TITL CRYO-EM STRUCTURE OF THE COMPLETE E. COLI DNA GYRASE
JRNL TITL 2 NUCLEOPROTEIN COMPLEX.
JRNL REF NAT COMMUN V. 10 4935 2019
JRNL REFN ESSN 2041-1723
JRNL PMID 31666516
JRNL DOI 10.1038/S41467-019-12914-Y
REMARK 2
REMARK 2 RESOLUTION. 4.00 ANGSTROMS.
REMARK 3
REMARK 3 REFINEMENT.
REMARK 3 SOFTWARE PACKAGES : SERIALEM, RELION, UCSF CHIMERA, PHENIX,
REMARK 3 CRYOSPARC, RELION, RELION
REMARK 3 RECONSTRUCTION SCHEMA : NULL
REMARK 3
REMARK 3 EM MAP-MODEL FITTING AND REFINEMENT
REMARK 3 PDB ENTRY : 3NUH
REMARK 3 REFINEMENT SPACE : REAL
REMARK 3 REFINEMENT PROTOCOL : NULL
REMARK 3 REFINEMENT TARGET : NULL
REMARK 3 OVERALL ANISOTROPIC B VALUE : NULL
REMARK 3
REMARK 3 FITTING PROCEDURE : NULL
REMARK 3
REMARK 3 EM IMAGE RECONSTRUCTION STATISTICS
REMARK 3 NOMINAL PIXEL SIZE (ANGSTROMS) : NULL
REMARK 3 ACTUAL PIXEL SIZE (ANGSTROMS) : NULL
REMARK 3 EFFECTIVE RESOLUTION (ANGSTROMS) : 4.000
REMARK 3 NUMBER OF PARTICLES : 60548
REMARK 3 CTF CORRECTION METHOD : PHASE FLIPPING AND AMPLITUDE
REMARK 3 CORRECTION
REMARK 3
REMARK 3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL
REMARK 3
REMARK 3 OTHER DETAILS: NULL
REMARK 4
REMARK 4 6RKU COMPLIES WITH FORMAT V. 3.30, 13-JUL-11
REMARK 100
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 30-APR-19.
REMARK 100 THE DEPOSITION ID IS D_1292101902.
REMARK 245
REMARK 245 EXPERIMENTAL DETAILS
REMARK 245 RECONSTRUCTION METHOD : SINGLE PARTICLE
REMARK 245 SPECIMEN TYPE : NULL
REMARK 245
REMARK 245 ELECTRON MICROSCOPE SAMPLE
REMARK 245 SAMPLE TYPE : PARTICLE
REMARK 245 PARTICLE TYPE : POINT
REMARK 245 NAME OF SAMPLE : DNA BINDING AND CLEAVAGE DOMAIN
REMARK 245 OF THE E. COLI DNA GYRASE IN
REMARK 245 STATE 1; DNA GYRASE; DNA
REMARK 245 SAMPLE CONCENTRATION (MG ML-1) : NULL
REMARK 245 SAMPLE SUPPORT DETAILS : NULL
REMARK 245 SAMPLE VITRIFICATION DETAILS : NULL
REMARK 245 SAMPLE BUFFER : NULL
REMARK 245 PH : 8.00
REMARK 245 SAMPLE DETAILS : NULL
REMARK 245
REMARK 245 DATA ACQUISITION
REMARK 245 DATE OF EXPERIMENT : NULL
REMARK 245 NUMBER OF MICROGRAPHS-IMAGES : NULL
REMARK 245 TEMPERATURE (KELVIN) : NULL
REMARK 245 MICROSCOPE MODEL : FEI TITAN KRIOS
REMARK 245 DETECTOR TYPE : GATAN K2 SUMMIT (4K X 4K)
REMARK 245 MINIMUM DEFOCUS (NM) : 300.00
REMARK 245 MAXIMUM DEFOCUS (NM) : 800.00
REMARK 245 MINIMUM TILT ANGLE (DEGREES) : NULL
REMARK 245 MAXIMUM TILT ANGLE (DEGREES) : NULL
REMARK 245 NOMINAL CS : 0.01
REMARK 245 IMAGING MODE : BRIGHT FIELD
REMARK 245 ELECTRON DOSE (ELECTRONS NM**-2) : 50.00
REMARK 245 ILLUMINATION MODE : FLOOD BEAM
REMARK 245 NOMINAL MAGNIFICATION : 130000
REMARK 245 CALIBRATED MAGNIFICATION : NULL
REMARK 245 SOURCE : FIELD EMISSION GUN
REMARK 245 ACCELERATION VOLTAGE (KV) : 300
REMARK 245 IMAGING DETAILS : NULL
REMARK 247
REMARK 247 ELECTRON MICROSCOPY
REMARK 247 THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON
REMARK 247 MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE
REMARK 247 THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES
REMARK 247 ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION
REMARK 247 OF THE STRUCTURE FACTORS.
REMARK 300
REMARK 300 BIOMOLECULE: 1
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON
REMARK 300 BURIED SURFACE AREA.
REMARK 350
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS
REMARK 350 GIVEN BELOW. BOTH NON-CRYSTALLOGRAPHIC AND
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.
REMARK 350
REMARK 350 BIOMOLECULE: 1
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: OCTAMERIC
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: OCTAMERIC
REMARK 350 SOFTWARE USED: PISA
REMARK 350 TOTAL BURIED SURFACE AREA: 22000 ANGSTROM**2
REMARK 350 SURFACE AREA OF THE COMPLEX: 103300 ANGSTROM**2
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -82.0 KCAL/MOL
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, F, E, G, H
REMARK 350 BIOMT1 1 1.000000 0.000000 0.000000 0.00000
REMARK 350 BIOMT2 1 0.000000 1.000000 0.000000 0.00000
REMARK 350 BIOMT3 1 0.000000 0.000000 1.000000 0.00000
REMARK 465
REMARK 465 MISSING RESIDUES
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)
REMARK 465
REMARK 465 M RES C SSSEQI
REMARK 465 MET A 1
REMARK 465 SER A 2
REMARK 465 ASP A 3
REMARK 465 LEU A 4
REMARK 465 ALA A 5
REMARK 465 ARG A 6
REMARK 465 GLU A 7
REMARK 465 MET A 423
REMARK 465 LEU A 424
REMARK 465 GLU A 425
REMARK 465 ARG A 426
REMARK 465 ARG A 444
REMARK 465 ASP A 445
REMARK 465 SER A 525
REMARK 465 ALA A 526
REMARK 465 ASP A 527
REMARK 465 ILE A 528
REMARK 465 ASN A 529
REMARK 465 LEU A 530
REMARK 465 GLU A 531
REMARK 465 ASP A 532
REMARK 465 LEU A 533
REMARK 465 ILE A 534
REMARK 465 THR A 535
REMARK 465 GLN A 536
REMARK 465 GLU A 537
REMARK 465 ASP A 538
REMARK 465 VAL A 539
REMARK 465 VAL A 540
REMARK 465 VAL A 541
REMARK 465 THR A 542
REMARK 465 LEU A 543
REMARK 465 SER A 544
REMARK 465 HIS A 545
REMARK 465 GLN A 546
REMARK 465 GLY A 547
REMARK 465 TYR A 548
REMARK 465 VAL A 549
REMARK 465 LYS A 550
REMARK 465 TYR A 551
REMARK 465 GLN A 552
REMARK 465 PRO A 553
REMARK 465 LEU A 554
REMARK 465 SER A 555
REMARK 465 GLU A 556
REMARK 465 TYR A 557
REMARK 465 GLU A 558
REMARK 465 ALA A 559
REMARK 465 GLN A 560
REMARK 465 ARG A 561
REMARK 465 ARG A 562
REMARK 465 GLY A 563
REMARK 465 GLY A 564
REMARK 465 LYS A 565
REMARK 465 GLY A 566
REMARK 465 LYS A 567
REMARK 465 SER A 568
REMARK 465 ALA A 569
REMARK 465 ALA A 570
REMARK 465 ARG A 571
REMARK 465 ILE A 572
REMARK 465 LYS A 573
REMARK 465 GLU A 574
REMARK 465 GLU A 575
REMARK 465 ASP A 576
REMARK 465 PHE A 577
REMARK 465 ILE A 578
REMARK 465 ASP A 579
REMARK 465 ARG A 580
REMARK 465 LEU A 581
REMARK 465 LEU A 582
REMARK 465 VAL A 583
REMARK 465 ALA A 584
REMARK 465 ASN A 585
REMARK 465 THR A 586
REMARK 465 HIS A 587
REMARK 465 ASP A 588
REMARK 465 HIS A 589
REMARK 465 ILE A 590
REMARK 465 LEU A 591
REMARK 465 CYS A 592
REMARK 465 PHE A 593
REMARK 465 SER A 594
REMARK 465 SER A 595
REMARK 465 ARG A 596
REMARK 465 GLY A 597
REMARK 465 ARG A 598
REMARK 465 VAL A 599
REMARK 465 TYR A 600
REMARK 465 SER A 601
REMARK 465 MET A 602
REMARK 465 LYS A 603
REMARK 465 VAL A 604
REMARK 465 TYR A 605
REMARK 465 GLN A 606
REMARK 465 LEU A 607
REMARK 465 PRO A 608
REMARK 465 GLU A 609
REMARK 465 ALA A 610
REMARK 465 THR A 611
REMARK 465 ARG A 612
REMARK 465 GLY A 613
REMARK 465 ALA A 614
REMARK 465 ARG A 615
REMARK 465 GLY A 616
REMARK 465 ARG A 617
REMARK 465 PRO A 618
REMARK 465 ILE A 619
REMARK 465 VAL A 620
REMARK 465 ASN A 621
REMARK 465 LEU A 622
REMARK 465 LEU A 623
REMARK 465 PRO A 624
REMARK 465 LEU A 625
REMARK 465 GLU A 626
REMARK 465 GLN A 627
REMARK 465 ASP A 628
REMARK 465 GLU A 629
REMARK 465 ARG A 630
REMARK 465 ILE A 631
REMARK 465 THR A 632
REMARK 465 ALA A 633
REMARK 465 ILE A 634
REMARK 465 LEU A 635
REMARK 465 PRO A 636
REMARK 465 VAL A 637
REMARK 465 THR A 638
REMARK 465 GLU A 639
REMARK 465 PHE A 640
REMARK 465 GLU A 641
REMARK 465 GLU A 642
REMARK 465 GLY A 643
REMARK 465 VAL A 644
REMARK 465 LYS A 645
REMARK 465 VAL A 646
REMARK 465 PHE A 647
REMARK 465 MET A 648
REMARK 465 ALA A 649
REMARK 465 THR A 650
REMARK 465 ALA A 651
REMARK 465 ASN A 652
REMARK 465 GLY A 653
REMARK 465 THR A 654
REMARK 465 VAL A 655
REMARK 465 LYS A 656
REMARK 465 LYS A 657
REMARK 465 THR A 658
REMARK 465 VAL A 659
REMARK 465 LEU A 660
REMARK 465 THR A 661
REMARK 465 GLU A 662
REMARK 465 PHE A 663
REMARK 465 ASN A 664
REMARK 465 ARG A 665
REMARK 465 LEU A 666
REMARK 465 ARG A 667
REMARK 465 THR A 668
REMARK 465 ALA A 669
REMARK 465 GLY A 670
REMARK 465 LYS A 671
REMARK 465 VAL A 672
REMARK 465 ALA A 673
REMARK 465 ILE A 674
REMARK 465 LYS A 675
REMARK 465 LEU A 676
REMARK 465 VAL A 677
REMARK 465 ASP A 678
REMARK 465 GLY A 679
REMARK 465 ASP A 680
REMARK 465 GLU A 681
REMARK 465 LEU A 682
REMARK 465 ILE A 683
REMARK 465 GLY A 684
REMARK 465 VAL A 685
REMARK 465 ASP A 686
REMARK 465 LEU A 687
REMARK 465 THR A 688
REMARK 465 SER A 689
REMARK 465 GLY A 690
REMARK 465 GLU A 691
REMARK 465 ASP A 692
REMARK 465 GLU A 693
REMARK 465 VAL A 694
REMARK 465 MET A 695
REMARK 465 LEU A 696
REMARK 465 PHE A 697
REMARK 465 SER A 698
REMARK 465 ALA A 699
REMARK 465 GLU A 700
REMARK 465 GLY A 701
REMARK 465 LYS A 702
REMARK 465 VAL A 703
REMARK 465 VAL A 704
REMARK 465 ARG A 705
REMARK 465 PHE A 706
REMARK 465 LYS A 707
REMARK 465 GLU A 708
REMARK 465 SER A 709
REMARK 465 SER A 710
REMARK 465 VAL A 711
REMARK 465 ARG A 712
REMARK 465 ALA A 713
REMARK 465 MET A 714
REMARK 465 GLY A 715
REMARK 465 CYS A 716
REMARK 465 ASN A 717
REMARK 465 THR A 718
REMARK 465 THR A 719
REMARK 465 GLY A 720
REMARK 465 VAL A 721
REMARK 465 ARG A 722
REMARK 465 GLY A 723
REMARK 465 ILE A 724
REMARK 465 ARG A 725
REMARK 465 LEU A 726
REMARK 465 GLY A 727
REMARK 465 GLU A 728
REMARK 465 GLY A 729
REMARK 465 ASP A 730
REMARK 465 LYS A 731
REMARK 465 VAL A 732
REMARK 465 VAL A 733
REMARK 465 SER A 734
REMARK 465 LEU A 735
REMARK 465 ILE A 736
REMARK 465 VAL A 737
REMARK 465 PRO A 738
REMARK 465 ARG A 739
REMARK 465 GLY A 740
REMARK 465 ASP A 741
REMARK 465 GLY A 742
REMARK 465 ALA A 743
REMARK 465 ILE A 744
REMARK 465 LEU A 745
REMARK 465 THR A 746
REMARK 465 ALA A 747
REMARK 465 THR A 748
REMARK 465 GLN A 749
REMARK 465 ASN A 750
REMARK 465 GLY A 751
REMARK 465 TYR A 752
REMARK 465 GLY A 753
REMARK 465 LYS A 754
REMARK 465 ARG A 755
REMARK 465 THR A 756
REMARK 465 ALA A 757
REMARK 465 VAL A 758
REMARK 465 ALA A 759
REMARK 465 GLU A 760
REMARK 465 TYR A 761
REMARK 465 PRO A 762
REMARK 465 THR A 763
REMARK 465 LYS A 764
REMARK 465 SER A 765
REMARK 465 ARG A 766
REMARK 465 ALA A 767
REMARK 465 THR A 768
REMARK 465 LYS A 769
REMARK 465 GLY A 770
REMARK 465 VAL A 771
REMARK 465 ILE A 772
REMARK 465 SER A 773
REMARK 465 ILE A 774
REMARK 465 LYS A 775
REMARK 465 VAL A 776
REMARK 465 THR A 777
REMARK 465 GLU A 778
REMARK 465 ARG A 779
REMARK 465 ASN A 780
REMARK 465 GLY A 781
REMARK 465 LEU A 782
REMARK 465 VAL A 783
REMARK 465 VAL A 784
REMARK 465 GLY A 785
REMARK 465 ALA A 786
REMARK 465 VAL A 787
REMARK 465 GLN A 788
REMARK 465 VAL A 789
REMARK 465 ASP A 790
REMARK 465 ASP A 791
REMARK 465 CYS A 792
REMARK 465 ASP A 793
REMARK 465 GLN A 794
REMARK 465 ILE A 795
REMARK 465 MET A 796
REMARK 465 MET A 797
REMARK 465 ILE A 798
REMARK 465 THR A 799
REMARK 465 ASP A 800
REMARK 465 ALA A 801
REMARK 465 GLY A 802
REMARK 465 THR A 803
REMARK 465 LEU A 804
REMARK 465 VAL A 805
REMARK 465 ARG A 806
REMARK 465 THR A 807
REMARK 465 ARG A 808
REMARK 465 VAL A 809
REMARK 465 SER A 810
REMARK 465 GLU A 811
REMARK 465 ILE A 812
REMARK 465 SER A 813
REMARK 465 ILE A 814
REMARK 465 VAL A 815
REMARK 465 GLY A 816
REMARK 465 ARG A 817
REMARK 465 ASN A 818
REMARK 465 THR A 819
REMARK 465 GLN A 820
REMARK 465 GLY A 821
REMARK 465 VAL A 822
REMARK 465 ILE A 823
REMARK 465 LEU A 824
REMARK 465 ILE A 825
REMARK 465 ARG A 826
REMARK 465 THR A 827
REMARK 465 ALA A 828
REMARK 465 GLU A 829
REMARK 465 ASP A 830
REMARK 465 GLU A 831
REMARK 465 ASN A 832
REMARK 465 VAL A 833
REMARK 465 VAL A 834
REMARK 465 GLY A 835
REMARK 465 LEU A 836
REMARK 465 GLN A 837
REMARK 465 ARG A 838
REMARK 465 VAL A 839
REMARK 465 ALA A 840
REMARK 465 GLU A 841
REMARK 465 PRO A 842
REMARK 465 VAL A 843
REMARK 465 ASP A 844
REMARK 465 GLU A 845
REMARK 465 GLU A 846
REMARK 465 ASP A 847
REMARK 465 LEU A 848
REMARK 465 ASP A 849
REMARK 465 THR A 850
REMARK 465 ILE A 851
REMARK 465 ASP A 852
REMARK 465 GLY A 853
REMARK 465 SER A 854
REMARK 465 ALA A 855
REMARK 465 ALA A 856
REMARK 465 GLU A 857
REMARK 465 GLY A 858
REMARK 465 ASP A 859
REMARK 465 ASP A 860
REMARK 465 GLU A 861
REMARK 465 ILE A 862
REMARK 465 ALA A 863
REMARK 465 PRO A 864
REMARK 465 GLU A 865
REMARK 465 VAL A 866
REMARK 465 ASP A 867
REMARK 465 VAL A 868
REMARK 465 ASP A 869
REMARK 465 ASP A 870
REMARK 465 GLU A 871
REMARK 465 PRO A 872
REMARK 465 GLU A 873
REMARK 465 GLU A 874
REMARK 465 GLU A 875
REMARK 465 MET B 1
REMARK 465 SER B 2
REMARK 465 ASN B 3
REMARK 465 SER B 4
REMARK 465 TYR B 5
REMARK 465 ASP B 6
REMARK 465 SER B 7
REMARK 465 SER B 8
REMARK 465 SER B 9
REMARK 465 ILE B 10
REMARK 465 LYS B 11
REMARK 465 VAL B 12
REMARK 465 LEU B 13
REMARK 465 LYS B 14
REMARK 465 GLY B 15
REMARK 465 LEU B 16
REMARK 465 ASP B 17
REMARK 465 ALA B 18
REMARK 465 VAL B 19
REMARK 465 ARG B 20
REMARK 465 LYS B 21
REMARK 465 ARG B 22
REMARK 465 PRO B 23
REMARK 465 GLY B 24
REMARK 465 MET B 25
REMARK 465 TYR B 26
REMARK 465 ILE B 27
REMARK 465 GLY B 28
REMARK 465 ASP B 29
REMARK 465 THR B 30
REMARK 465 ASP B 31
REMARK 465 ASP B 32
REMARK 465 GLY B 33
REMARK 465 THR B 34
REMARK 465 GLY B 35
REMARK 465 LEU B 36
REMARK 465 HIS B 37
REMARK 465 HIS B 38
REMARK 465 MET B 39
REMARK 465 VAL B 40
REMARK 465 PHE B 41
REMARK 465 GLU B 42
REMARK 465 VAL B 43
REMARK 465 VAL B 44
REMARK 465 ASP B 45
REMARK 465 ASN B 46
REMARK 465 ALA B 47
REMARK 465 ILE B 48
REMARK 465 ASP B 49
REMARK 465 GLU B 50
REMARK 465 ALA B 51
REMARK 465 LEU B 52
REMARK 465 ALA B 53
REMARK 465 GLY B 54
REMARK 465 HIS B 55
REMARK 465 CYS B 56
REMARK 465 LYS B 57
REMARK 465 GLU B 58
REMARK 465 ILE B 59
REMARK 465 ILE B 60
REMARK 465 VAL B 61
REMARK 465 THR B 62
REMARK 465 ILE B 63
REMARK 465 HIS B 64
REMARK 465 ALA B 65
REMARK 465 ASP B 66
REMARK 465 ASN B 67
REMARK 465 SER B 68
REMARK 465 VAL B 69
REMARK 465 SER B 70
REMARK 465 VAL B 71
REMARK 465 GLN B 72
REMARK 465 ASP B 73
REMARK 465 ASP B 74
REMARK 465 GLY B 75
REMARK 465 ARG B 76
REMARK 465 GLY B 77
REMARK 465 ILE B 78
REMARK 465 PRO B 79
REMARK 465 THR B 80
REMARK 465 GLY B 81
REMARK 465 ILE B 82
REMARK 465 HIS B 83
REMARK 465 PRO B 84
REMARK 465 GLU B 85
REMARK 465 GLU B 86
REMARK 465 GLY B 87
REMARK 465 VAL B 88
REMARK 465 SER B 89
REMARK 465 ALA B 90
REMARK 465 ALA B 91
REMARK 465 GLU B 92
REMARK 465 VAL B 93
REMARK 465 ILE B 94
REMARK 465 MET B 95
REMARK 465 THR B 96
REMARK 465 VAL B 97
REMARK 465 LEU B 98
REMARK 465 HIS B 99
REMARK 465 ALA B 100
REMARK 465 GLY B 101
REMARK 465 GLY B 102
REMARK 465 LYS B 103
REMARK 465 PHE B 104
REMARK 465 ASP B 105
REMARK 465 ASP B 106
REMARK 465 ASN B 107
REMARK 465 SER B 108
REMARK 465 TYR B 109
REMARK 465 LYS B 110
REMARK 465 VAL B 111
REMARK 465 SER B 112
REMARK 465 GLY B 113
REMARK 465 GLY B 114
REMARK 465 LEU B 115
REMARK 465 HIS B 116
REMARK 465 GLY B 117
REMARK 465 VAL B 118
REMARK 465 GLY B 119
REMARK 465 VAL B 120
REMARK 465 SER B 121
REMARK 465 VAL B 122
REMARK 465 VAL B 123
REMARK 465 ASN B 124
REMARK 465 ALA B 125
REMARK 465 LEU B 126
REMARK 465 SER B 127
REMARK 465 GLN B 128
REMARK 465 LYS B 129
REMARK 465 LEU B 130
REMARK 465 GLU B 131
REMARK 465 LEU B 132
REMARK 465 VAL B 133
REMARK 465 ILE B 134
REMARK 465 GLN B 135
REMARK 465 ARG B 136
REMARK 465 GLU B 137
REMARK 465 GLY B 138
REMARK 465 LYS B 139
REMARK 465 ILE B 140
REMARK 465 HIS B 141
REMARK 465 ARG B 142
REMARK 465 GLN B 143
REMARK 465 ILE B 144
REMARK 465 TYR B 145
REMARK 465 GLU B 146
REMARK 465 HIS B 147
REMARK 465 GLY B 148
REMARK 465 VAL B 149
REMARK 465 PRO B 150
REMARK 465 GLN B 151
REMARK 465 ALA B 152
REMARK 465 PRO B 153
REMARK 465 LEU B 154
REMARK 465 ALA B 155
REMARK 465 VAL B 156
REMARK 465 THR B 157
REMARK 465 GLY B 158
REMARK 465 GLU B 159
REMARK 465 THR B 160
REMARK 465 GLU B 161
REMARK 465 LYS B 162
REMARK 465 THR B 163
REMARK 465 GLY B 164
REMARK 465 THR B 165
REMARK 465 MET B 166
REMARK 465 VAL B 167
REMARK 465 ARG B 168
REMARK 465 PHE B 169
REMARK 465 TRP B 170
REMARK 465 PRO B 171
REMARK 465 SER B 172
REMARK 465 LEU B 173
REMARK 465 GLU B 174
REMARK 465 THR B 175
REMARK 465 PHE B 176
REMARK 465 THR B 177
REMARK 465 ASN B 178
REMARK 465 VAL B 179
REMARK 465 THR B 180
REMARK 465 GLU B 181
REMARK 465 PHE B 182
REMARK 465 GLU B 183
REMARK 465 TYR B 184
REMARK 465 GLU B 185
REMARK 465 ILE B 186
REMARK 465 LEU B 187
REMARK 465 ALA B 188
REMARK 465 LYS B 189
REMARK 465 ARG B 190
REMARK 465 LEU B 191
REMARK 465 ARG B 192
REMARK 465 GLU B 193
REMARK 465 LEU B 194
REMARK 465 SER B 195
REMARK 465 PHE B 196
REMARK 465 LEU B 197
REMARK 465 ASN B 198
REMARK 465 SER B 199
REMARK 465 GLY B 200
REMARK 465 VAL B 201
REMARK 465 SER B 202
REMARK 465 ILE B 203
REMARK 465 ARG B 204
REMARK 465 LEU B 205
REMARK 465 ARG B 206
REMARK 465 ASP B 207
REMARK 465 LYS B 208
REMARK 465 ARG B 209
REMARK 465 ASP B 210
REMARK 465 GLY B 211
REMARK 465 LYS B 212
REMARK 465 GLU B 213
REMARK 465 ASP B 214
REMARK 465 HIS B 215
REMARK 465 PHE B 216
REMARK 465 HIS B 217
REMARK 465 TYR B 218
REMARK 465 GLU B 219
REMARK 465 GLY B 220
REMARK 465 GLY B 221
REMARK 465 ILE B 222
REMARK 465 LYS B 223
REMARK 465 ALA B 224
REMARK 465 PHE B 225
REMARK 465 VAL B 226
REMARK 465 GLU B 227
REMARK 465 TYR B 228
REMARK 465 LEU B 229
REMARK 465 ASN B 230
REMARK 465 LYS B 231
REMARK 465 ASN B 232
REMARK 465 LYS B 233
REMARK 465 THR B 234
REMARK 465 PRO B 235
REMARK 465 ILE B 236
REMARK 465 HIS B 237
REMARK 465 PRO B 238
REMARK 465 ASN B 239
REMARK 465 ILE B 240
REMARK 465 PHE B 241
REMARK 465 TYR B 242
REMARK 465 PHE B 243
REMARK 465 SER B 244
REMARK 465 THR B 245
REMARK 465 GLU B 246
REMARK 465 LYS B 247
REMARK 465 ASP B 248
REMARK 465 GLY B 249
REMARK 465 ILE B 250
REMARK 465 GLY B 251
REMARK 465 VAL B 252
REMARK 465 GLU B 253
REMARK 465 VAL B 254
REMARK 465 ALA B 255
REMARK 465 LEU B 256
REMARK 465 GLN B 257
REMARK 465 TRP B 258
REMARK 465 ASN B 259
REMARK 465 ASP B 260
REMARK 465 GLY B 261
REMARK 465 PHE B 262
REMARK 465 GLN B 263
REMARK 465 GLU B 264
REMARK 465 ASN B 265
REMARK 465 ILE B 266
REMARK 465 TYR B 267
REMARK 465 CYS B 268
REMARK 465 PHE B 269
REMARK 465 THR B 270
REMARK 465 ASN B 271
REMARK 465 ASN B 272
REMARK 465 ILE B 273
REMARK 465 PRO B 274
REMARK 465 GLN B 275
REMARK 465 ARG B 276
REMARK 465 ASP B 277
REMARK 465 GLY B 278
REMARK 465 GLY B 279
REMARK 465 THR B 280
REMARK 465 HIS B 281
REMARK 465 LEU B 282
REMARK 465 ALA B 283
REMARK 465 GLY B 284
REMARK 465 PHE B 285
REMARK 465 ARG B 286
REMARK 465 ALA B 287
REMARK 465 ALA B 288
REMARK 465 MET B 289
REMARK 465 THR B 290
REMARK 465 ARG B 291
REMARK 465 THR B 292
REMARK 465 LEU B 293
REMARK 465 ASN B 294
REMARK 465 ALA B 295
REMARK 465 TYR B 296
REMARK 465 MET B 297
REMARK 465 ASP B 298
REMARK 465 LYS B 299
REMARK 465 GLU B 300
REMARK 465 GLY B 301
REMARK 465 TYR B 302
REMARK 465 SER B 303
REMARK 465 LYS B 304
REMARK 465 LYS B 305
REMARK 465 ALA B 306
REMARK 465 LYS B 307
REMARK 465 VAL B 308
REMARK 465 SER B 309
REMARK 465 ALA B 310
REMARK 465 THR B 311
REMARK 465 GLY B 312
REMARK 465 ASP B 313
REMARK 465 ASP B 314
REMARK 465 ALA B 315
REMARK 465 ARG B 316
REMARK 465 GLU B 317
REMARK 465 GLY B 318
REMARK 465 LEU B 319
REMARK 465 ILE B 320
REMARK 465 ALA B 321
REMARK 465 VAL B 322
REMARK 465 VAL B 323
REMARK 465 SER B 324
REMARK 465 VAL B 325
REMARK 465 LYS B 326
REMARK 465 VAL B 327
REMARK 465 PRO B 328
REMARK 465 ASP B 329
REMARK 465 PRO B 330
REMARK 465 LYS B 331
REMARK 465 PHE B 332
REMARK 465 SER B 333
REMARK 465 SER B 334
REMARK 465 GLN B 335
REMARK 465 THR B 336
REMARK 465 LYS B 337
REMARK 465 ASP B 338
REMARK 465 LYS B 339
REMARK 465 LEU B 340
REMARK 465 VAL B 341
REMARK 465 SER B 342
REMARK 465 SER B 343
REMARK 465 GLU B 344
REMARK 465 VAL B 345
REMARK 465 LYS B 346
REMARK 465 SER B 347
REMARK 465 ALA B 348
REMARK 465 VAL B 349
REMARK 465 GLU B 350
REMARK 465 GLN B 351
REMARK 465 GLN B 352
REMARK 465 MET B 353
REMARK 465 ASN B 354
REMARK 465 GLU B 355
REMARK 465 LEU B 356
REMARK 465 LEU B 357
REMARK 465 ALA B 358
REMARK 465 GLU B 359
REMARK 465 TYR B 360
REMARK 465 LEU B 361
REMARK 465 LEU B 362
REMARK 465 GLU B 363
REMARK 465 ASN B 364
REMARK 465 PRO B 365
REMARK 465 THR B 366
REMARK 465 ASP B 367
REMARK 465 ALA B 368
REMARK 465 LYS B 369
REMARK 465 ILE B 370
REMARK 465 VAL B 371
REMARK 465 VAL B 372
REMARK 465 GLY B 373
REMARK 465 LYS B 374
REMARK 465 ILE B 375
REMARK 465 ILE B 376
REMARK 465 ASP B 377
REMARK 465 ALA B 378
REMARK 465 ALA B 379
REMARK 465 ARG B 380
REMARK 465 ALA B 381
REMARK 465 ARG B 382
REMARK 465 GLU B 383
REMARK 465 ALA B 384
REMARK 465 ALA B 385
REMARK 465 ARG B 386
REMARK 465 ARG B 387
REMARK 465 ALA B 388
REMARK 465 ARG B 389
REMARK 465 GLU B 390
REMARK 465 MET B 391
REMARK 465 THR B 392
REMARK 465 ARG B 393
REMARK 465 ARG B 394
REMARK 465 LYS B 395
REMARK 465 GLY B 396
REMARK 465 ALA B 397
REMARK 465 LEU B 398
REMARK 465 ASP B 399
REMARK 465 LEU B 400
REMARK 465 ALA B 401
REMARK 465 GLY B 475
REMARK 465 CYS B 476
REMARK 465 GLY B 477
REMARK 465 ILE B 478
REMARK 465 GLY B 479
REMARK 465 ARG B 480
REMARK 465 ASP B 481
REMARK 465 GLU B 482
REMARK 465 PHE B 791
REMARK 465 ILE B 792
REMARK 465 GLU B 793
REMARK 465 GLU B 794
REMARK 465 ASN B 795
REMARK 465 ALA B 796
REMARK 465 LEU B 797
REMARK 465 LYS B 798
REMARK 465 ALA B 799
REMARK 465 ALA B 800
REMARK 465 ASN B 801
REMARK 465 ILE B 802
REMARK 465 ASP B 803
REMARK 465 ILE B 804
REMARK 465 MET C 1
REMARK 465 SER C 2
REMARK 465 ASP C 3
REMARK 465 LEU C 4
REMARK 465 ALA C 5
REMARK 465 ARG C 6
REMARK 465 GLU C 7
REMARK 465 MET C 423
REMARK 465 LEU C 424
REMARK 465 GLU C 425
REMARK 465 ARG C 426
REMARK 465 ARG C 444
REMARK 465 ASP C 445
REMARK 465 SER C 525
REMARK 465 ALA C 526
REMARK 465 ASP C 527
REMARK 465 ILE C 528
REMARK 465 ASN C 529
REMARK 465 LEU C 530
REMARK 465 GLU C 531
REMARK 465 ASP C 532
REMARK 465 LEU C 533
REMARK 465 ILE C 534
REMARK 465 THR C 535
REMARK 465 GLN C 536
REMARK 465 GLU C 537
REMARK 465 ASP C 538
REMARK 465 VAL C 539
REMARK 465 VAL C 540
REMARK 465 VAL C 541
REMARK 465 THR C 542
REMARK 465 LEU C 543
REMARK 465 SER C 544
REMARK 465 HIS C 545
REMARK 465 GLN C 546
REMARK 465 GLY C 547
REMARK 465 TYR C 548
REMARK 465 VAL C 549
REMARK 465 LYS C 550
REMARK 465 TYR C 551
REMARK 465 GLN C 552
REMARK 465 PRO C 553
REMARK 465 LEU C 554
REMARK 465 SER C 555
REMARK 465 GLU C 556
REMARK 465 TYR C 557
REMARK 465 GLU C 558
REMARK 465 ALA C 559
REMARK 465 GLN C 560
REMARK 465 ARG C 561
REMARK 465 ARG C 562
REMARK 465 GLY C 563
REMARK 465 GLY C 564
REMARK 465 LYS C 565
REMARK 465 GLY C 566
REMARK 465 LYS C 567
REMARK 465 SER C 568
REMARK 465 ALA C 569
REMARK 465 ALA C 570
REMARK 465 ARG C 571
REMARK 465 ILE C 572
REMARK 465 LYS C 573
REMARK 465 GLU C 574
REMARK 465 GLU C 575
REMARK 465 ASP C 576
REMARK 465 PHE C 577
REMARK 465 ILE C 578
REMARK 465 ASP C 579
REMARK 465 ARG C 580
REMARK 465 LEU C 581
REMARK 465 LEU C 582
REMARK 465 VAL C 583
REMARK 465 ALA C 584
REMARK 465 ASN C 585
REMARK 465 THR C 586
REMARK 465 HIS C 587
REMARK 465 ASP C 588
REMARK 465 HIS C 589
REMARK 465 ILE C 590
REMARK 465 LEU C 591
REMARK 465 CYS C 592
REMARK 465 PHE C 593
REMARK 465 SER C 594
REMARK 465 SER C 595
REMARK 465 ARG C 596
REMARK 465 GLY C 597
REMARK 465 ARG C 598
REMARK 465 VAL C 599
REMARK 465 TYR C 600
REMARK 465 SER C 601
REMARK 465 MET C 602
REMARK 465 LYS C 603
REMARK 465 VAL C 604
REMARK 465 TYR C 605
REMARK 465 GLN C 606
REMARK 465 LEU C 607
REMARK 465 PRO C 608
REMARK 465 GLU C 609
REMARK 465 ALA C 610
REMARK 465 THR C 611
REMARK 465 ARG C 612
REMARK 465 GLY C 613
REMARK 465 ALA C 614
REMARK 465 ARG C 615
REMARK 465 GLY C 616
REMARK 465 ARG C 617
REMARK 465 PRO C 618
REMARK 465 ILE C 619
REMARK 465 VAL C 620
REMARK 465 ASN C 621
REMARK 465 LEU C 622
REMARK 465 LEU C 623
REMARK 465 PRO C 624
REMARK 465 LEU C 625
REMARK 465 GLU C 626
REMARK 465 GLN C 627
REMARK 465 ASP C 628
REMARK 465 GLU C 629
REMARK 465 ARG C 630
REMARK 465 ILE C 631
REMARK 465 THR C 632
REMARK 465 ALA C 633
REMARK 465 ILE C 634
REMARK 465 LEU C 635
REMARK 465 PRO C 636
REMARK 465 VAL C 637
REMARK 465 THR C 638
REMARK 465 GLU C 639
REMARK 465 PHE C 640
REMARK 465 GLU C 641
REMARK 465 GLU C 642
REMARK 465 GLY C 643
REMARK 465 VAL C 644
REMARK 465 LYS C 645
REMARK 465 VAL C 646
REMARK 465 PHE C 647
REMARK 465 MET C 648
REMARK 465 ALA C 649
REMARK 465 THR C 650
REMARK 465 ALA C 651
REMARK 465 ASN C 652
REMARK 465 GLY C 653
REMARK 465 THR C 654
REMARK 465 VAL C 655
REMARK 465 LYS C 656
REMARK 465 LYS C 657
REMARK 465 THR C 658
REMARK 465 VAL C 659
REMARK 465 LEU C 660
REMARK 465 THR C 661
REMARK 465 GLU C 662
REMARK 465 PHE C 663
REMARK 465 ASN C 664
REMARK 465 ARG C 665
REMARK 465 LEU C 666
REMARK 465 ARG C 667
REMARK 465 THR C 668
REMARK 465 ALA C 669
REMARK 465 GLY C 670
REMARK 465 LYS C 671
REMARK 465 VAL C 672
REMARK 465 ALA C 673
REMARK 465 ILE C 674
REMARK 465 LYS C 675
REMARK 465 LEU C 676
REMARK 465 VAL C 677
REMARK 465 ASP C 678
REMARK 465 GLY C 679
REMARK 465 ASP C 680
REMARK 465 GLU C 681
REMARK 465 LEU C 682
REMARK 465 ILE C 683
REMARK 465 GLY C 684
REMARK 465 VAL C 685
REMARK 465 ASP C 686
REMARK 465 LEU C 687
REMARK 465 THR C 688
REMARK 465 SER C 689
REMARK 465 GLY C 690
REMARK 465 GLU C 691
REMARK 465 ASP C 692
REMARK 465 GLU C 693
REMARK 465 VAL C 694
REMARK 465 MET C 695
REMARK 465 LEU C 696
REMARK 465 PHE C 697
REMARK 465 SER C 698
REMARK 465 ALA C 699
REMARK 465 GLU C 700
REMARK 465 GLY C 701
REMARK 465 LYS C 702
REMARK 465 VAL C 703
REMARK 465 VAL C 704
REMARK 465 ARG C 705
REMARK 465 PHE C 706
REMARK 465 LYS C 707
REMARK 465 GLU C 708
REMARK 465 SER C 709
REMARK 465 SER C 710
REMARK 465 VAL C 711
REMARK 465 ARG C 712
REMARK 465 ALA C 713
REMARK 465 MET C 714
REMARK 465 GLY C 715
REMARK 465 CYS C 716
REMARK 465 ASN C 717
REMARK 465 THR C 718
REMARK 465 THR C 719
REMARK 465 GLY C 720
REMARK 465 VAL C 721
REMARK 465 ARG C 722
REMARK 465 GLY C 723
REMARK 465 ILE C 724
REMARK 465 ARG C 725
REMARK 465 LEU C 726
REMARK 465 GLY C 727
REMARK 465 GLU C 728
REMARK 465 GLY C 729
REMARK 465 ASP C 730
REMARK 465 LYS C 731
REMARK 465 VAL C 732
REMARK 465 VAL C 733
REMARK 465 SER C 734
REMARK 465 LEU C 735
REMARK 465 ILE C 736
REMARK 465 VAL C 737
REMARK 465 PRO C 738
REMARK 465 ARG C 739
REMARK 465 GLY C 740
REMARK 465 ASP C 741
REMARK 465 GLY C 742
REMARK 465 ALA C 743
REMARK 465 ILE C 744
REMARK 465 LEU C 745
REMARK 465 THR C 746
REMARK 465 ALA C 747
REMARK 465 THR C 748
REMARK 465 GLN C 749
REMARK 465 ASN C 750
REMARK 465 GLY C 751
REMARK 465 TYR C 752
REMARK 465 GLY C 753
REMARK 465 LYS C 754
REMARK 465 ARG C 755
REMARK 465 THR C 756
REMARK 465 ALA C 757
REMARK 465 VAL C 758
REMARK 465 ALA C 759
REMARK 465 GLU C 760
REMARK 465 TYR C 761
REMARK 465 PRO C 762
REMARK 465 THR C 763
REMARK 465 LYS C 764
REMARK 465 SER C 765
REMARK 465 ARG C 766
REMARK 465 ALA C 767
REMARK 465 THR C 768
REMARK 465 LYS C 769
REMARK 465 GLY C 770
REMARK 465 VAL C 771
REMARK 465 ILE C 772
REMARK 465 SER C 773
REMARK 465 ILE C 774
REMARK 465 LYS C 775
REMARK 465 VAL C 776
REMARK 465 THR C 777
REMARK 465 GLU C 778
REMARK 465 ARG C 779
REMARK 465 ASN C 780
REMARK 465 GLY C 781
REMARK 465 LEU C 782
REMARK 465 VAL C 783
REMARK 465 VAL C 784
REMARK 465 GLY C 785
REMARK 465 ALA C 786
REMARK 465 VAL C 787
REMARK 465 GLN C 788
REMARK 465 VAL C 789
REMARK 465 ASP C 790
REMARK 465 ASP C 791
REMARK 465 CYS C 792
REMARK 465 ASP C 793
REMARK 465 GLN C 794
REMARK 465 ILE C 795
REMARK 465 MET C 796
REMARK 465 MET C 797
REMARK 465 ILE C 798
REMARK 465 THR C 799
REMARK 465 ASP C 800
REMARK 465 ALA C 801
REMARK 465 GLY C 802
REMARK 465 THR C 803
REMARK 465 LEU C 804
REMARK 465 VAL C 805
REMARK 465 ARG C 806
REMARK 465 THR C 807
REMARK 465 ARG C 808
REMARK 465 VAL C 809
REMARK 465 SER C 810
REMARK 465 GLU C 811
REMARK 465 ILE C 812
REMARK 465 SER C 813
REMARK 465 ILE C 814
REMARK 465 VAL C 815
REMARK 465 GLY C 816
REMARK 465 ARG C 817
REMARK 465 ASN C 818
REMARK 465 THR C 819
REMARK 465 GLN C 820
REMARK 465 GLY C 821
REMARK 465 VAL C 822
REMARK 465 ILE C 823
REMARK 465 LEU C 824
REMARK 465 ILE C 825
REMARK 465 ARG C 826
REMARK 465 THR C 827
REMARK 465 ALA C 828
REMARK 465 GLU C 829
REMARK 465 ASP C 830
REMARK 465 GLU C 831
REMARK 465 ASN C 832
REMARK 465 VAL C 833
REMARK 465 VAL C 834
REMARK 465 GLY C 835
REMARK 465 LEU C 836
REMARK 465 GLN C 837
REMARK 465 ARG C 838
REMARK 465 VAL C 839
REMARK 465 ALA C 840
REMARK 465 GLU C 841
REMARK 465 PRO C 842
REMARK 465 VAL C 843
REMARK 465 ASP C 844
REMARK 465 GLU C 845
REMARK 465 GLU C 846
REMARK 465 ASP C 847
REMARK 465 LEU C 848
REMARK 465 ASP C 849
REMARK 465 THR C 850
REMARK 465 ILE C 851
REMARK 465 ASP C 852
REMARK 465 GLY C 853
REMARK 465 SER C 854
REMARK 465 ALA C 855
REMARK 465 ALA C 856
REMARK 465 GLU C 857
REMARK 465 GLY C 858
REMARK 465 ASP C 859
REMARK 465 ASP C 860
REMARK 465 GLU C 861
REMARK 465 ILE C 862
REMARK 465 ALA C 863
REMARK 465 PRO C 864
REMARK 465 GLU C 865
REMARK 465 VAL C 866
REMARK 465 ASP C 867
REMARK 465 VAL C 868
REMARK 465 ASP C 869
REMARK 465 ASP C 870
REMARK 465 GLU C 871
REMARK 465 PRO C 872
REMARK 465 GLU C 873
REMARK 465 GLU C 874
REMARK 465 GLU C 875
REMARK 465 MET D 1
REMARK 465 SER D 2
REMARK 465 ASN D 3
REMARK 465 SER D 4
REMARK 465 TYR D 5
REMARK 465 ASP D 6
REMARK 465 SER D 7
REMARK 465 SER D 8
REMARK 465 SER D 9
REMARK 465 ILE D 10
REMARK 465 LYS D 11
REMARK 465 VAL D 12
REMARK 465 LEU D 13
REMARK 465 LYS D 14
REMARK 465 GLY D 15
REMARK 465 LEU D 16
REMARK 465 ASP D 17
REMARK 465 ALA D 18
REMARK 465 VAL D 19
REMARK 465 ARG D 20
REMARK 465 LYS D 21
REMARK 465 ARG D 22
REMARK 465 PRO D 23
REMARK 465 GLY D 24
REMARK 465 MET D 25
REMARK 465 TYR D 26
REMARK 465 ILE D 27
REMARK 465 GLY D 28
REMARK 465 ASP D 29
REMARK 465 THR D 30
REMARK 465 ASP D 31
REMARK 465 ASP D 32
REMARK 465 GLY D 33
REMARK 465 THR D 34
REMARK 465 GLY D 35
REMARK 465 LEU D 36
REMARK 465 HIS D 37
REMARK 465 HIS D 38
REMARK 465 MET D 39
REMARK 465 VAL D 40
REMARK 465 PHE D 41
REMARK 465 GLU D 42
REMARK 465 VAL D 43
REMARK 465 VAL D 44
REMARK 465 ASP D 45
REMARK 465 ASN D 46
REMARK 465 ALA D 47
REMARK 465 ILE D 48
REMARK 465 ASP D 49
REMARK 465 GLU D 50
REMARK 465 ALA D 51
REMARK 465 LEU D 52
REMARK 465 ALA D 53
REMARK 465 GLY D 54
REMARK 465 HIS D 55
REMARK 465 CYS D 56
REMARK 465 LYS D 57
REMARK 465 GLU D 58
REMARK 465 ILE D 59
REMARK 465 ILE D 60
REMARK 465 VAL D 61
REMARK 465 THR D 62
REMARK 465 ILE D 63
REMARK 465 HIS D 64
REMARK 465 ALA D 65
REMARK 465 ASP D 66
REMARK 465 ASN D 67
REMARK 465 SER D 68
REMARK 465 VAL D 69
REMARK 465 SER D 70
REMARK 465 VAL D 71
REMARK 465 GLN D 72
REMARK 465 ASP D 73
REMARK 465 ASP D 74
REMARK 465 GLY D 75
REMARK 465 ARG D 76
REMARK 465 GLY D 77
REMARK 465 ILE D 78
REMARK 465 PRO D 79
REMARK 465 THR D 80
REMARK 465 GLY D 81
REMARK 465 ILE D 82
REMARK 465 HIS D 83
REMARK 465 PRO D 84
REMARK 465 GLU D 85
REMARK 465 GLU D 86
REMARK 465 GLY D 87
REMARK 465 VAL D 88
REMARK 465 SER D 89
REMARK 465 ALA D 90
REMARK 465 ALA D 91
REMARK 465 GLU D 92
REMARK 465 VAL D 93
REMARK 465 ILE D 94
REMARK 465 MET D 95
REMARK 465 THR D 96
REMARK 465 VAL D 97
REMARK 465 LEU D 98
REMARK 465 HIS D 99
REMARK 465 ALA D 100
REMARK 465 GLY D 101
REMARK 465 GLY D 102
REMARK 465 LYS D 103
REMARK 465 PHE D 104
REMARK 465 ASP D 105
REMARK 465 ASP D 106
REMARK 465 ASN D 107
REMARK 465 SER D 108
REMARK 465 TYR D 109
REMARK 465 LYS D 110
REMARK 465 VAL D 111
REMARK 465 SER D 112
REMARK 465 GLY D 113
REMARK 465 GLY D 114
REMARK 465 LEU D 115
REMARK 465 HIS D 116
REMARK 465 GLY D 117
REMARK 465 VAL D 118
REMARK 465 GLY D 119
REMARK 465 VAL D 120
REMARK 465 SER D 121
REMARK 465 VAL D 122
REMARK 465 VAL D 123
REMARK 465 ASN D 124
REMARK 465 ALA D 125
REMARK 465 LEU D 126
REMARK 465 SER D 127
REMARK 465 GLN D 128
REMARK 465 LYS D 129
REMARK 465 LEU D 130
REMARK 465 GLU D 131
REMARK 465 LEU D 132
REMARK 465 VAL D 133
REMARK 465 ILE D 134
REMARK 465 GLN D 135
REMARK 465 ARG D 136
REMARK 465 GLU D 137
REMARK 465 GLY D 138
REMARK 465 LYS D 139
REMARK 465 ILE D 140
REMARK 465 HIS D 141
REMARK 465 ARG D 142
REMARK 465 GLN D 143
REMARK 465 ILE D 144
REMARK 465 TYR D 145
REMARK 465 GLU D 146
REMARK 465 HIS D 147
REMARK 465 GLY D 148
REMARK 465 VAL D 149
REMARK 465 PRO D 150
REMARK 465 GLN D 151
REMARK 465 ALA D 152
REMARK 465 PRO D 153
REMARK 465 LEU D 154
REMARK 465 ALA D 155
REMARK 465 VAL D 156
REMARK 465 THR D 157
REMARK 465 GLY D 158
REMARK 465 GLU D 159
REMARK 465 THR D 160
REMARK 465 GLU D 161
REMARK 465 LYS D 162
REMARK 465 THR D 163
REMARK 465 GLY D 164
REMARK 465 THR D 165
REMARK 465 MET D 166
REMARK 465 VAL D 167
REMARK 465 ARG D 168
REMARK 465 PHE D 169
REMARK 465 TRP D 170
REMARK 465 PRO D 171
REMARK 465 SER D 172
REMARK 465 LEU D 173
REMARK 465 GLU D 174
REMARK 465 THR D 175
REMARK 465 PHE D 176
REMARK 465 THR D 177
REMARK 465 ASN D 178
REMARK 465 VAL D 179
REMARK 465 THR D 180
REMARK 465 GLU D 181
REMARK 465 PHE D 182
REMARK 465 GLU D 183
REMARK 465 TYR D 184
REMARK 465 GLU D 185
REMARK 465 ILE D 186
REMARK 465 LEU D 187
REMARK 465 ALA D 188
REMARK 465 LYS D 189
REMARK 465 ARG D 190
REMARK 465 LEU D 191
REMARK 465 ARG D 192
REMARK 465 GLU D 193
REMARK 465 LEU D 194
REMARK 465 SER D 195
REMARK 465 PHE D 196
REMARK 465 LEU D 197
REMARK 465 ASN D 198
REMARK 465 SER D 199
REMARK 465 GLY D 200
REMARK 465 VAL D 201
REMARK 465 SER D 202
REMARK 465 ILE D 203
REMARK 465 ARG D 204
REMARK 465 LEU D 205
REMARK 465 ARG D 206
REMARK 465 ASP D 207
REMARK 465 LYS D 208
REMARK 465 ARG D 209
REMARK 465 ASP D 210
REMARK 465 GLY D 211
REMARK 465 LYS D 212
REMARK 465 GLU D 213
REMARK 465 ASP D 214
REMARK 465 HIS D 215
REMARK 465 PHE D 216
REMARK 465 HIS D 217
REMARK 465 TYR D 218
REMARK 465 GLU D 219
REMARK 465 GLY D 220
REMARK 465 GLY D 221
REMARK 465 ILE D 222
REMARK 465 LYS D 223
REMARK 465 ALA D 224
REMARK 465 PHE D 225
REMARK 465 VAL D 226
REMARK 465 GLU D 227
REMARK 465 TYR D 228
REMARK 465 LEU D 229
REMARK 465 ASN D 230
REMARK 465 LYS D 231
REMARK 465 ASN D 232
REMARK 465 LYS D 233
REMARK 465 THR D 234
REMARK 465 PRO D 235
REMARK 465 ILE D 236
REMARK 465 HIS D 237
REMARK 465 PRO D 238
REMARK 465 ASN D 239
REMARK 465 ILE D 240
REMARK 465 PHE D 241
REMARK 465 TYR D 242
REMARK 465 PHE D 243
REMARK 465 SER D 244
REMARK 465 THR D 245
REMARK 465 GLU D 246
REMARK 465 LYS D 247
REMARK 465 ASP D 248
REMARK 465 GLY D 249
REMARK 465 ILE D 250
REMARK 465 GLY D 251
REMARK 465 VAL D 252
REMARK 465 GLU D 253
REMARK 465 VAL D 254
REMARK 465 ALA D 255
REMARK 465 LEU D 256
REMARK 465 GLN D 257
REMARK 465 TRP D 258
REMARK 465 ASN D 259
REMARK 465 ASP D 260
REMARK 465 GLY D 261
REMARK 465 PHE D 262
REMARK 465 GLN D 263
REMARK 465 GLU D 264
REMARK 465 ASN D 265
REMARK 465 ILE D 266
REMARK 465 TYR D 267
REMARK 465 CYS D 268
REMARK 465 PHE D 269
REMARK 465 THR D 270
REMARK 465 ASN D 271
REMARK 465 ASN D 272
REMARK 465 ILE D 273
REMARK 465 PRO D 274
REMARK 465 GLN D 275
REMARK 465 ARG D 276
REMARK 465 ASP D 277
REMARK 465 GLY D 278
REMARK 465 GLY D 279
REMARK 465 THR D 280
REMARK 465 HIS D 281
REMARK 465 LEU D 282
REMARK 465 ALA D 283
REMARK 465 GLY D 284
REMARK 465 PHE D 285
REMARK 465 ARG D 286
REMARK 465 ALA D 287
REMARK 465 ALA D 288
REMARK 465 MET D 289
REMARK 465 THR D 290
REMARK 465 ARG D 291
REMARK 465 THR D 292
REMARK 465 LEU D 293
REMARK 465 ASN D 294
REMARK 465 ALA D 295
REMARK 465 TYR D 296
REMARK 465 MET D 297
REMARK 465 ASP D 298
REMARK 465 LYS D 299
REMARK 465 GLU D 300
REMARK 465 GLY D 301
REMARK 465 TYR D 302
REMARK 465 SER D 303
REMARK 465 LYS D 304
REMARK 465 LYS D 305
REMARK 465 ALA D 306
REMARK 465 LYS D 307
REMARK 465 VAL D 308
REMARK 465 SER D 309
REMARK 465 ALA D 310
REMARK 465 THR D 311
REMARK 465 GLY D 312
REMARK 465 ASP D 313
REMARK 465 ASP D 314
REMARK 465 ALA D 315
REMARK 465 ARG D 316
REMARK 465 GLU D 317
REMARK 465 GLY D 318
REMARK 465 LEU D 319
REMARK 465 ILE D 320
REMARK 465 ALA D 321
REMARK 465 VAL D 322
REMARK 465 VAL D 323
REMARK 465 SER D 324
REMARK 465 VAL D 325
REMARK 465 LYS D 326
REMARK 465 VAL D 327
REMARK 465 PRO D 328
REMARK 465 ASP D 329
REMARK 465 PRO D 330
REMARK 465 LYS D 331
REMARK 465 PHE D 332
REMARK 465 SER D 333
REMARK 465 SER D 334
REMARK 465 GLN D 335
REMARK 465 THR D 336
REMARK 465 LYS D 337
REMARK 465 ASP D 338
REMARK 465 LYS D 339
REMARK 465 LEU D 340
REMARK 465 VAL D 341
REMARK 465 SER D 342
REMARK 465 SER D 343
REMARK 465 GLU D 344
REMARK 465 VAL D 345
REMARK 465 LYS D 346
REMARK 465 SER D 347
REMARK 465 ALA D 348
REMARK 465 VAL D 349
REMARK 465 GLU D 350
REMARK 465 GLN D 351
REMARK 465 GLN D 352
REMARK 465 MET D 353
REMARK 465 ASN D 354
REMARK 465 GLU D 355
REMARK 465 LEU D 356
REMARK 465 LEU D 357
REMARK 465 ALA D 358
REMARK 465 GLU D 359
REMARK 465 TYR D 360
REMARK 465 LEU D 361
REMARK 465 LEU D 362
REMARK 465 GLU D 363
REMARK 465 ASN D 364
REMARK 465 PRO D 365
REMARK 465 THR D 366
REMARK 465 ASP D 367
REMARK 465 ALA D 368
REMARK 465 LYS D 369
REMARK 465 ILE D 370
REMARK 465 VAL D 371
REMARK 465 VAL D 372
REMARK 465 GLY D 373
REMARK 465 LYS D 374
REMARK 465 ILE D 375
REMARK 465 ILE D 376
REMARK 465 ASP D 377
REMARK 465 ALA D 378
REMARK 465 ALA D 379
REMARK 465 ARG D 380
REMARK 465 ALA D 381
REMARK 465 ARG D 382
REMARK 465 GLU D 383
REMARK 465 ALA D 384
REMARK 465 ALA D 385
REMARK 465 ARG D 386
REMARK 465 ARG D 387
REMARK 465 ALA D 388
REMARK 465 ARG D 389
REMARK 465 GLU D 390
REMARK 465 MET D 391
REMARK 465 THR D 392
REMARK 465 ARG D 393
REMARK 465 ARG D 394
REMARK 465 LYS D 395
REMARK 465 GLY D 396
REMARK 465 ALA D 397
REMARK 465 LEU D 398
REMARK 465 ASP D 399
REMARK 465 LEU D 400
REMARK 465 ALA D 401
REMARK 465 GLY D 475
REMARK 465 CYS D 476
REMARK 465 GLY D 477
REMARK 465 ILE D 478
REMARK 465 GLY D 479
REMARK 465 ARG D 480
REMARK 465 ASP D 481
REMARK 465 GLU D 482
REMARK 465 PHE D 791
REMARK 465 ILE D 792
REMARK 465 GLU D 793
REMARK 465 GLU D 794
REMARK 465 ASN D 795
REMARK 465 ALA D 796
REMARK 465 LEU D 797
REMARK 465 LYS D 798
REMARK 465 ALA D 799
REMARK 465 ALA D 800
REMARK 465 ASN D 801
REMARK 465 ILE D 802
REMARK 465 ASP D 803
REMARK 465 ILE D 804
REMARK 500
REMARK 500 GEOMETRY AND STEREOCHEMISTRY
REMARK 500 SUBTOPIC: TORSION ANGLES
REMARK 500
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).
REMARK 500
REMARK 500 STANDARD TABLE:
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)
REMARK 500
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400
REMARK 500
REMARK 500 M RES CSSEQI PSI PHI
REMARK 500 PRO A 215 -178.12 -69.67
REMARK 500 ALA A 221 -167.48 -163.03
REMARK 500 PRO A 265 -179.59 -66.01
REMARK 500 GLN A 325 -6.80 -59.72
REMARK 500 PRO A 414 -177.02 -69.84
REMARK 500 PRO A 439 0.71 -67.52
REMARK 500 ASP A 515 -168.97 -161.85
REMARK 500 SER B 464 -62.57 -93.77
REMARK 500 LEU B 561 41.36 -103.32
REMARK 500 ALA B 655 -169.72 -167.45
REMARK 500 ASN B 658 -67.53 -125.35
REMARK 500 LEU B 659 57.52 32.24
REMARK 500 LEU B 780 -17.35 72.62
REMARK 500 PRO B 787 77.42 -67.10
REMARK 500 PRO C 215 -178.13 -69.81
REMARK 500 ALA C 221 -167.47 -163.05
REMARK 500 PRO C 265 -179.55 -65.95
REMARK 500 GLN C 325 -6.71 -59.79
REMARK 500 PRO C 414 -177.04 -69.82
REMARK 500 PRO C 439 0.68 -67.58
REMARK 500 ASP C 515 -168.99 -161.89
REMARK 500 SER D 464 -62.51 -93.80
REMARK 500 LEU D 561 41.31 -103.30
REMARK 500 ALA D 655 -169.74 -167.50
REMARK 500 ASN D 658 -67.55 -125.36
REMARK 500 LEU D 659 57.40 32.36
REMARK 500 LEU D 780 -17.40 72.67
REMARK 500 PRO D 787 77.46 -67.11
REMARK 500
REMARK 500 REMARK: NULL
REMARK 800
REMARK 800 SITE
REMARK 800 SITE_IDENTIFIER: AC1
REMARK 800 EVIDENCE_CODE: SOFTWARE
REMARK 800 SITE_DESCRIPTION: binding site for residue JHN G 101
REMARK 900
REMARK 900 RELATED ENTRIES
REMARK 900 RELATED ID: EMD-4910 RELATED DB: EMDB
REMARK 900 E. COLI DNA GYRASE - DNA BINDING AND CLEAVAGE DOMAIN IN STATE 1
DBREF 6RKU A 1 875 UNP P0AES4 GYRA_ECOLI 1 875
DBREF 6RKU B 1 804 UNP P0AES6 GYRB_ECOLI 1 804
DBREF 6RKU C 1 875 UNP P0AES4 GYRA_ECOLI 1 875
DBREF 6RKU D 1 804 UNP P0AES6 GYRB_ECOLI 1 804
DBREF 6RKU F 1 14 PDB 6RKU 6RKU 1 14
DBREF 6RKU E 1 14 PDB 6RKU 6RKU 1 14
DBREF 6RKU G 15 32 PDB 6RKU 6RKU 15 32
DBREF 6RKU H 15 32 PDB 6RKU 6RKU 15 32
SEQRES 1 A 875 MET SER ASP LEU ALA ARG GLU ILE THR PRO VAL ASN ILE
SEQRES 2 A 875 GLU GLU GLU LEU LYS SER SER TYR LEU ASP TYR ALA MET
SEQRES 3 A 875 SER VAL ILE VAL GLY ARG ALA LEU PRO ASP VAL ARG ASP
SEQRES 4 A 875 GLY LEU LYS PRO VAL HIS ARG ARG VAL LEU TYR ALA MET
SEQRES 5 A 875 ASN VAL LEU GLY ASN ASP TRP ASN LYS ALA TYR LYS LYS
SEQRES 6 A 875 SER ALA ARG VAL VAL GLY ASP VAL ILE GLY LYS TYR HIS
SEQRES 7 A 875 PRO HIS GLY ASP SER ALA VAL TYR ASP THR ILE VAL ARG
SEQRES 8 A 875 MET ALA GLN PRO PHE SER LEU ARG TYR MET LEU VAL ASP
SEQRES 9 A 875 GLY GLN GLY ASN PHE GLY SER ILE ASP GLY ASP SER ALA
SEQRES 10 A 875 ALA ALA MET ARG TYR THR GLU ILE ARG LEU ALA LYS ILE
SEQRES 11 A 875 ALA HIS GLU LEU MET ALA ASP LEU GLU LYS GLU THR VAL
SEQRES 12 A 875 ASP PHE VAL ASP ASN TYR ASP GLY THR GLU LYS ILE PRO
SEQRES 13 A 875 ASP VAL MET PRO THR LYS ILE PRO ASN LEU LEU VAL ASN
SEQRES 14 A 875 GLY SER SER GLY ILE ALA VAL GLY MET ALA THR ASN ILE
SEQRES 15 A 875 PRO PRO HIS ASN LEU THR GLU VAL ILE ASN GLY CYS LEU
SEQRES 16 A 875 ALA TYR ILE ASP ASP GLU ASP ILE SER ILE GLU GLY LEU
SEQRES 17 A 875 MET GLU HIS ILE PRO GLY PRO ASP PHE PRO THR ALA ALA
SEQRES 18 A 875 ILE ILE ASN GLY ARG ARG GLY ILE GLU GLU ALA TYR ARG
SEQRES 19 A 875 THR GLY ARG GLY LYS VAL TYR ILE ARG ALA ARG ALA GLU
SEQRES 20 A 875 VAL GLU VAL ASP ALA LYS THR GLY ARG GLU THR ILE ILE
SEQRES 21 A 875 VAL HIS GLU ILE PRO TYR GLN VAL ASN LYS ALA ARG LEU
SEQRES 22 A 875 ILE GLU LYS ILE ALA GLU LEU VAL LYS GLU LYS ARG VAL
SEQRES 23 A 875 GLU GLY ILE SER ALA LEU ARG ASP GLU SER ASP LYS ASP
SEQRES 24 A 875 GLY MET ARG ILE VAL ILE GLU VAL LYS ARG ASP ALA VAL
SEQRES 25 A 875 GLY GLU VAL VAL LEU ASN ASN LEU TYR SER GLN THR GLN
SEQRES 26 A 875 LEU GLN VAL SER PHE GLY ILE ASN MET VAL ALA LEU HIS
SEQRES 27 A 875 HIS GLY GLN PRO LYS ILE MET ASN LEU LYS ASP ILE ILE
SEQRES 28 A 875 ALA ALA PHE VAL ARG HIS ARG ARG GLU VAL VAL THR ARG
SEQRES 29 A 875 ARG THR ILE PHE GLU LEU ARG LYS ALA ARG ASP ARG ALA
SEQRES 30 A 875 HIS ILE LEU GLU ALA LEU ALA VAL ALA LEU ALA ASN ILE
SEQRES 31 A 875 ASP PRO ILE ILE GLU LEU ILE ARG HIS ALA PRO THR PRO
SEQRES 32 A 875 ALA GLU ALA LYS THR ALA LEU VAL ALA ASN PRO TRP GLN
SEQRES 33 A 875 LEU GLY ASN VAL ALA ALA MET LEU GLU ARG ALA GLY ASP
SEQRES 34 A 875 ASP ALA ALA ARG PRO GLU TRP LEU GLU PRO GLU PHE GLY
SEQRES 35 A 875 VAL ARG ASP GLY LEU TYR TYR LEU THR GLU GLN GLN ALA
SEQRES 36 A 875 GLN ALA ILE LEU ASP LEU ARG LEU GLN LYS LEU THR GLY
SEQRES 37 A 875 LEU GLU HIS GLU LYS LEU LEU ASP GLU TYR LYS GLU LEU
SEQRES 38 A 875 LEU ASP GLN ILE ALA GLU LEU LEU ARG ILE LEU GLY SER
SEQRES 39 A 875 ALA ASP ARG LEU MET GLU VAL ILE ARG GLU GLU LEU GLU
SEQRES 40 A 875 LEU VAL ARG GLU GLN PHE GLY ASP LYS ARG ARG THR GLU
SEQRES 41 A 875 ILE THR ALA ASN SER ALA ASP ILE ASN LEU GLU ASP LEU
SEQRES 42 A 875 ILE THR GLN GLU ASP VAL VAL VAL THR LEU SER HIS GLN
SEQRES 43 A 875 GLY TYR VAL LYS TYR GLN PRO LEU SER GLU TYR GLU ALA
SEQRES 44 A 875 GLN ARG ARG GLY GLY LYS GLY LYS SER ALA ALA ARG ILE
SEQRES 45 A 875 LYS GLU GLU ASP PHE ILE ASP ARG LEU LEU VAL ALA ASN
SEQRES 46 A 875 THR HIS ASP HIS ILE LEU CYS PHE SER SER ARG GLY ARG
SEQRES 47 A 875 VAL TYR SER MET LYS VAL TYR GLN LEU PRO GLU ALA THR
SEQRES 48 A 875 ARG GLY ALA ARG GLY ARG PRO ILE VAL ASN LEU LEU PRO
SEQRES 49 A 875 LEU GLU GLN ASP GLU ARG ILE THR ALA ILE LEU PRO VAL
SEQRES 50 A 875 THR GLU PHE GLU GLU GLY VAL LYS VAL PHE MET ALA THR
SEQRES 51 A 875 ALA ASN GLY THR VAL LYS LYS THR VAL LEU THR GLU PHE
SEQRES 52 A 875 ASN ARG LEU ARG THR ALA GLY LYS VAL ALA ILE LYS LEU
SEQRES 53 A 875 VAL ASP GLY ASP GLU LEU ILE GLY VAL ASP LEU THR SER
SEQRES 54 A 875 GLY GLU ASP GLU VAL MET LEU PHE SER ALA GLU GLY LYS
SEQRES 55 A 875 VAL VAL ARG PHE LYS GLU SER SER VAL ARG ALA MET GLY
SEQRES 56 A 875 CYS ASN THR THR GLY VAL ARG GLY ILE ARG LEU GLY GLU
SEQRES 57 A 875 GLY ASP LYS VAL VAL SER LEU ILE VAL PRO ARG GLY ASP
SEQRES 58 A 875 GLY ALA ILE LEU THR ALA THR GLN ASN GLY TYR GLY LYS
SEQRES 59 A 875 ARG THR ALA VAL ALA GLU TYR PRO THR LYS SER ARG ALA
SEQRES 60 A 875 THR LYS GLY VAL ILE SER ILE LYS VAL THR GLU ARG ASN
SEQRES 61 A 875 GLY LEU VAL VAL GLY ALA VAL GLN VAL ASP ASP CYS ASP
SEQRES 62 A 875 GLN ILE MET MET ILE THR ASP ALA GLY THR LEU VAL ARG
SEQRES 63 A 875 THR ARG VAL SER GLU ILE SER ILE VAL GLY ARG ASN THR
SEQRES 64 A 875 GLN GLY VAL ILE LEU ILE ARG THR ALA GLU ASP GLU ASN
SEQRES 65 A 875 VAL VAL GLY LEU GLN ARG VAL ALA GLU PRO VAL ASP GLU
SEQRES 66 A 875 GLU ASP LEU ASP THR ILE ASP GLY SER ALA ALA GLU GLY
SEQRES 67 A 875 ASP ASP GLU ILE ALA PRO GLU VAL ASP VAL ASP ASP GLU
SEQRES 68 A 875 PRO GLU GLU GLU
SEQRES 1 B 804 MET SER ASN SER TYR ASP SER SER SER ILE LYS VAL LEU
SEQRES 2 B 804 LYS GLY LEU ASP ALA VAL ARG LYS ARG PRO GLY MET TYR
SEQRES 3 B 804 ILE GLY ASP THR ASP ASP GLY THR GLY LEU HIS HIS MET
SEQRES 4 B 804 VAL PHE GLU VAL VAL ASP ASN ALA ILE ASP GLU ALA LEU
SEQRES 5 B 804 ALA GLY HIS CYS LYS GLU ILE ILE VAL THR ILE HIS ALA
SEQRES 6 B 804 ASP ASN SER VAL SER VAL GLN ASP ASP GLY ARG GLY ILE
SEQRES 7 B 804 PRO THR GLY ILE HIS PRO GLU GLU GLY VAL SER ALA ALA
SEQRES 8 B 804 GLU VAL ILE MET THR VAL LEU HIS ALA GLY GLY LYS PHE
SEQRES 9 B 804 ASP ASP ASN SER TYR LYS VAL SER GLY GLY LEU HIS GLY
SEQRES 10 B 804 VAL GLY VAL SER VAL VAL ASN ALA LEU SER GLN LYS LEU
SEQRES 11 B 804 GLU LEU VAL ILE GLN ARG GLU GLY LYS ILE HIS ARG GLN
SEQRES 12 B 804 ILE TYR GLU HIS GLY VAL PRO GLN ALA PRO LEU ALA VAL
SEQRES 13 B 804 THR GLY GLU THR GLU LYS THR GLY THR MET VAL ARG PHE
SEQRES 14 B 804 TRP PRO SER LEU GLU THR PHE THR ASN VAL THR GLU PHE
SEQRES 15 B 804 GLU TYR GLU ILE LEU ALA LYS ARG LEU ARG GLU LEU SER
SEQRES 16 B 804 PHE LEU ASN SER GLY VAL SER ILE ARG LEU ARG ASP LYS
SEQRES 17 B 804 ARG ASP GLY LYS GLU ASP HIS PHE HIS TYR GLU GLY GLY
SEQRES 18 B 804 ILE LYS ALA PHE VAL GLU TYR LEU ASN LYS ASN LYS THR
SEQRES 19 B 804 PRO ILE HIS PRO ASN ILE PHE TYR PHE SER THR GLU LYS
SEQRES 20 B 804 ASP GLY ILE GLY VAL GLU VAL ALA LEU GLN TRP ASN ASP
SEQRES 21 B 804 GLY PHE GLN GLU ASN ILE TYR CYS PHE THR ASN ASN ILE
SEQRES 22 B 804 PRO GLN ARG ASP GLY GLY THR HIS LEU ALA GLY PHE ARG
SEQRES 23 B 804 ALA ALA MET THR ARG THR LEU ASN ALA TYR MET ASP LYS
SEQRES 24 B 804 GLU GLY TYR SER LYS LYS ALA LYS VAL SER ALA THR GLY
SEQRES 25 B 804 ASP ASP ALA ARG GLU GLY LEU ILE ALA VAL VAL SER VAL
SEQRES 26 B 804 LYS VAL PRO ASP PRO LYS PHE SER SER GLN THR LYS ASP
SEQRES 27 B 804 LYS LEU VAL SER SER GLU VAL LYS SER ALA VAL GLU GLN
SEQRES 28 B 804 GLN MET ASN GLU LEU LEU ALA GLU TYR LEU LEU GLU ASN
SEQRES 29 B 804 PRO THR ASP ALA LYS ILE VAL VAL GLY LYS ILE ILE ASP
SEQRES 30 B 804 ALA ALA ARG ALA ARG GLU ALA ALA ARG ARG ALA ARG GLU
SEQRES 31 B 804 MET THR ARG ARG LYS GLY ALA LEU ASP LEU ALA GLY LEU
SEQRES 32 B 804 PRO GLY LYS LEU ALA ASP CYS GLN GLU ARG ASP PRO ALA
SEQRES 33 B 804 LEU SER GLU LEU TYR LEU VAL GLU GLY ASP SER ALA GLY
SEQRES 34 B 804 GLY SER ALA LYS GLN GLY ARG ASN ARG LYS ASN GLN ALA
SEQRES 35 B 804 ILE LEU PRO LEU LYS GLY LYS ILE LEU ASN VAL GLU LYS
SEQRES 36 B 804 ALA ARG PHE ASP LYS MET LEU SER SER GLN GLU VAL ALA
SEQRES 37 B 804 THR LEU ILE THR ALA LEU GLY CYS GLY ILE GLY ARG ASP
SEQRES 38 B 804 GLU TYR ASN PRO ASP LYS LEU ARG TYR HIS SER ILE ILE
SEQRES 39 B 804 ILE MET THR ASP ALA ASP VAL ASP GLY SER HIS ILE ARG
SEQRES 40 B 804 THR LEU LEU LEU THR PHE PHE TYR ARG GLN MET PRO GLU
SEQRES 41 B 804 ILE VAL GLU ARG GLY HIS VAL TYR ILE ALA GLN PRO PRO
SEQRES 42 B 804 LEU TYR LYS VAL LYS LYS GLY LYS GLN GLU GLN TYR ILE
SEQRES 43 B 804 LYS ASP ASP GLU ALA MET ASP GLN TYR GLN ILE SER ILE
SEQRES 44 B 804 ALA LEU ASP GLY ALA THR LEU HIS THR ASN ALA SER ALA
SEQRES 45 B 804 PRO ALA LEU ALA GLY GLU ALA LEU GLU LYS LEU VAL SER
SEQRES 46 B 804 GLU TYR ASN ALA THR GLN LYS MET ILE ASN ARG MET GLU
SEQRES 47 B 804 ARG ARG TYR PRO LYS ALA MET LEU LYS GLU LEU ILE TYR
SEQRES 48 B 804 GLN PRO THR LEU THR GLU ALA ASP LEU SER ASP GLU GLN
SEQRES 49 B 804 THR VAL THR ARG TRP VAL ASN ALA LEU VAL SER GLU LEU
SEQRES 50 B 804 ASN ASP LYS GLU GLN HIS GLY SER GLN TRP LYS PHE ASP
SEQRES 51 B 804 VAL HIS THR ASN ALA GLU GLN ASN LEU PHE GLU PRO ILE
SEQRES 52 B 804 VAL ARG VAL ARG THR HIS GLY VAL ASP THR ASP TYR PRO
SEQRES 53 B 804 LEU ASP HIS GLU PHE ILE THR GLY GLY GLU TYR ARG ARG
SEQRES 54 B 804 ILE CYS THR LEU GLY GLU LYS LEU ARG GLY LEU LEU GLU
SEQRES 55 B 804 GLU ASP ALA PHE ILE GLU ARG GLY GLU ARG ARG GLN PRO
SEQRES 56 B 804 VAL ALA SER PHE GLU GLN ALA LEU ASP TRP LEU VAL LYS
SEQRES 57 B 804 GLU SER ARG ARG GLY LEU SER ILE GLN ARG TYR LYS GLY
SEQRES 58 B 804 LEU GLY GLU MET ASN PRO GLU GLN LEU TRP GLU THR THR
SEQRES 59 B 804 MET ASP PRO GLU SER ARG ARG MET LEU ARG VAL THR VAL
SEQRES 60 B 804 LYS ASP ALA ILE ALA ALA ASP GLN LEU PHE THR THR LEU
SEQRES 61 B 804 MET GLY ASP ALA VAL GLU PRO ARG ARG ALA PHE ILE GLU
SEQRES 62 B 804 GLU ASN ALA LEU LYS ALA ALA ASN ILE ASP ILE
SEQRES 1 C 875 MET SER ASP LEU ALA ARG GLU ILE THR PRO VAL ASN ILE
SEQRES 2 C 875 GLU GLU GLU LEU LYS SER SER TYR LEU ASP TYR ALA MET
SEQRES 3 C 875 SER VAL ILE VAL GLY ARG ALA LEU PRO ASP VAL ARG ASP
SEQRES 4 C 875 GLY LEU LYS PRO VAL HIS ARG ARG VAL LEU TYR ALA MET
SEQRES 5 C 875 ASN VAL LEU GLY ASN ASP TRP ASN LYS ALA TYR LYS LYS
SEQRES 6 C 875 SER ALA ARG VAL VAL GLY ASP VAL ILE GLY LYS TYR HIS
SEQRES 7 C 875 PRO HIS GLY ASP SER ALA VAL TYR ASP THR ILE VAL ARG
SEQRES 8 C 875 MET ALA GLN PRO PHE SER LEU ARG TYR MET LEU VAL ASP
SEQRES 9 C 875 GLY GLN GLY ASN PHE GLY SER ILE ASP GLY ASP SER ALA
SEQRES 10 C 875 ALA ALA MET ARG TYR THR GLU ILE ARG LEU ALA LYS ILE
SEQRES 11 C 875 ALA HIS GLU LEU MET ALA ASP LEU GLU LYS GLU THR VAL
SEQRES 12 C 875 ASP PHE VAL ASP ASN TYR ASP GLY THR GLU LYS ILE PRO
SEQRES 13 C 875 ASP VAL MET PRO THR LYS ILE PRO ASN LEU LEU VAL ASN
SEQRES 14 C 875 GLY SER SER GLY ILE ALA VAL GLY MET ALA THR ASN ILE
SEQRES 15 C 875 PRO PRO HIS ASN LEU THR GLU VAL ILE ASN GLY CYS LEU
SEQRES 16 C 875 ALA TYR ILE ASP ASP GLU ASP ILE SER ILE GLU GLY LEU
SEQRES 17 C 875 MET GLU HIS ILE PRO GLY PRO ASP PHE PRO THR ALA ALA
SEQRES 18 C 875 ILE ILE ASN GLY ARG ARG GLY ILE GLU GLU ALA TYR ARG
SEQRES 19 C 875 THR GLY ARG GLY LYS VAL TYR ILE ARG ALA ARG ALA GLU
SEQRES 20 C 875 VAL GLU VAL ASP ALA LYS THR GLY ARG GLU THR ILE ILE
SEQRES 21 C 875 VAL HIS GLU ILE PRO TYR GLN VAL ASN LYS ALA ARG LEU
SEQRES 22 C 875 ILE GLU LYS ILE ALA GLU LEU VAL LYS GLU LYS ARG VAL
SEQRES 23 C 875 GLU GLY ILE SER ALA LEU ARG ASP GLU SER ASP LYS ASP
SEQRES 24 C 875 GLY MET ARG ILE VAL ILE GLU VAL LYS ARG ASP ALA VAL
SEQRES 25 C 875 GLY GLU VAL VAL LEU ASN ASN LEU TYR SER GLN THR GLN
SEQRES 26 C 875 LEU GLN VAL SER PHE GLY ILE ASN MET VAL ALA LEU HIS
SEQRES 27 C 875 HIS GLY GLN PRO LYS ILE MET ASN LEU LYS ASP ILE ILE
SEQRES 28 C 875 ALA ALA PHE VAL ARG HIS ARG ARG GLU VAL VAL THR ARG
SEQRES 29 C 875 ARG THR ILE PHE GLU LEU ARG LYS ALA ARG ASP ARG ALA
SEQRES 30 C 875 HIS ILE LEU GLU ALA LEU ALA VAL ALA LEU ALA ASN ILE
SEQRES 31 C 875 ASP PRO ILE ILE GLU LEU ILE ARG HIS ALA PRO THR PRO
SEQRES 32 C 875 ALA GLU ALA LYS THR ALA LEU VAL ALA ASN PRO TRP GLN
SEQRES 33 C 875 LEU GLY ASN VAL ALA ALA MET LEU GLU ARG ALA GLY ASP
SEQRES 34 C 875 ASP ALA ALA ARG PRO GLU TRP LEU GLU PRO GLU PHE GLY
SEQRES 35 C 875 VAL ARG ASP GLY LEU TYR TYR LEU THR GLU GLN GLN ALA
SEQRES 36 C 875 GLN ALA ILE LEU ASP LEU ARG LEU GLN LYS LEU THR GLY
SEQRES 37 C 875 LEU GLU HIS GLU LYS LEU LEU ASP GLU TYR LYS GLU LEU
SEQRES 38 C 875 LEU ASP GLN ILE ALA GLU LEU LEU ARG ILE LEU GLY SER
SEQRES 39 C 875 ALA ASP ARG LEU MET GLU VAL ILE ARG GLU GLU LEU GLU
SEQRES 40 C 875 LEU VAL ARG GLU GLN PHE GLY ASP LYS ARG ARG THR GLU
SEQRES 41 C 875 ILE THR ALA ASN SER ALA ASP ILE ASN LEU GLU ASP LEU
SEQRES 42 C 875 ILE THR GLN GLU ASP VAL VAL VAL THR LEU SER HIS GLN
SEQRES 43 C 875 GLY TYR VAL LYS TYR GLN PRO LEU SER GLU TYR GLU ALA
SEQRES 44 C 875 GLN ARG ARG GLY GLY LYS GLY LYS SER ALA ALA ARG ILE
SEQRES 45 C 875 LYS GLU GLU ASP PHE ILE ASP ARG LEU LEU VAL ALA ASN
SEQRES 46 C 875 THR HIS ASP HIS ILE LEU CYS PHE SER SER ARG GLY ARG
SEQRES 47 C 875 VAL TYR SER MET LYS VAL TYR GLN LEU PRO GLU ALA THR
SEQRES 48 C 875 ARG GLY ALA ARG GLY ARG PRO ILE VAL ASN LEU LEU PRO
SEQRES 49 C 875 LEU GLU GLN ASP GLU ARG ILE THR ALA ILE LEU PRO VAL
SEQRES 50 C 875 THR GLU PHE GLU GLU GLY VAL LYS VAL PHE MET ALA THR
SEQRES 51 C 875 ALA ASN GLY THR VAL LYS LYS THR VAL LEU THR GLU PHE
SEQRES 52 C 875 ASN ARG LEU ARG THR ALA GLY LYS VAL ALA ILE LYS LEU
SEQRES 53 C 875 VAL ASP GLY ASP GLU LEU ILE GLY VAL ASP LEU THR SER
SEQRES 54 C 875 GLY GLU ASP GLU VAL MET LEU PHE SER ALA GLU GLY LYS
SEQRES 55 C 875 VAL VAL ARG PHE LYS GLU SER SER VAL ARG ALA MET GLY
SEQRES 56 C 875 CYS ASN THR THR GLY VAL ARG GLY ILE ARG LEU GLY GLU
SEQRES 57 C 875 GLY ASP LYS VAL VAL SER LEU ILE VAL PRO ARG GLY ASP
SEQRES 58 C 875 GLY ALA ILE LEU THR ALA THR GLN ASN GLY TYR GLY LYS
SEQRES 59 C 875 ARG THR ALA VAL ALA GLU TYR PRO THR LYS SER ARG ALA
SEQRES 60 C 875 THR LYS GLY VAL ILE SER ILE LYS VAL THR GLU ARG ASN
SEQRES 61 C 875 GLY LEU VAL VAL GLY ALA VAL GLN VAL ASP ASP CYS ASP
SEQRES 62 C 875 GLN ILE MET MET ILE THR ASP ALA GLY THR LEU VAL ARG
SEQRES 63 C 875 THR ARG VAL SER GLU ILE SER ILE VAL GLY ARG ASN THR
SEQRES 64 C 875 GLN GLY VAL ILE LEU ILE ARG THR ALA GLU ASP GLU ASN
SEQRES 65 C 875 VAL VAL GLY LEU GLN ARG VAL ALA GLU PRO VAL ASP GLU
SEQRES 66 C 875 GLU ASP LEU ASP THR ILE ASP GLY SER ALA ALA GLU GLY
SEQRES 67 C 875 ASP ASP GLU ILE ALA PRO GLU VAL ASP VAL ASP ASP GLU
SEQRES 68 C 875 PRO GLU GLU GLU
SEQRES 1 D 804 MET SER ASN SER TYR ASP SER SER SER ILE LYS VAL LEU
SEQRES 2 D 804 LYS GLY LEU ASP ALA VAL ARG LYS ARG PRO GLY MET TYR
SEQRES 3 D 804 ILE GLY ASP THR ASP ASP GLY THR GLY LEU HIS HIS MET
SEQRES 4 D 804 VAL PHE GLU VAL VAL ASP ASN ALA ILE ASP GLU ALA LEU
SEQRES 5 D 804 ALA GLY HIS CYS LYS GLU ILE ILE VAL THR ILE HIS ALA
SEQRES 6 D 804 ASP ASN SER VAL SER VAL GLN ASP ASP GLY ARG GLY ILE
SEQRES 7 D 804 PRO THR GLY ILE HIS PRO GLU GLU GLY VAL SER ALA ALA
SEQRES 8 D 804 GLU VAL ILE MET THR VAL LEU HIS ALA GLY GLY LYS PHE
SEQRES 9 D 804 ASP ASP ASN SER TYR LYS VAL SER GLY GLY LEU HIS GLY
SEQRES 10 D 804 VAL GLY VAL SER VAL VAL ASN ALA LEU SER GLN LYS LEU
SEQRES 11 D 804 GLU LEU VAL ILE GLN ARG GLU GLY LYS ILE HIS ARG GLN
SEQRES 12 D 804 ILE TYR GLU HIS GLY VAL PRO GLN ALA PRO LEU ALA VAL
SEQRES 13 D 804 THR GLY GLU THR GLU LYS THR GLY THR MET VAL ARG PHE
SEQRES 14 D 804 TRP PRO SER LEU GLU THR PHE THR ASN VAL THR GLU PHE
SEQRES 15 D 804 GLU TYR GLU ILE LEU ALA LYS ARG LEU ARG GLU LEU SER
SEQRES 16 D 804 PHE LEU ASN SER GLY VAL SER ILE ARG LEU ARG ASP LYS
SEQRES 17 D 804 ARG ASP GLY LYS GLU ASP HIS PHE HIS TYR GLU GLY GLY
SEQRES 18 D 804 ILE LYS ALA PHE VAL GLU TYR LEU ASN LYS ASN LYS THR
SEQRES 19 D 804 PRO ILE HIS PRO ASN ILE PHE TYR PHE SER THR GLU LYS
SEQRES 20 D 804 ASP GLY ILE GLY VAL GLU VAL ALA LEU GLN TRP ASN ASP
SEQRES 21 D 804 GLY PHE GLN GLU ASN ILE TYR CYS PHE THR ASN ASN ILE
SEQRES 22 D 804 PRO GLN ARG ASP GLY GLY THR HIS LEU ALA GLY PHE ARG
SEQRES 23 D 804 ALA ALA MET THR ARG THR LEU ASN ALA TYR MET ASP LYS
SEQRES 24 D 804 GLU GLY TYR SER LYS LYS ALA LYS VAL SER ALA THR GLY
SEQRES 25 D 804 ASP ASP ALA ARG GLU GLY LEU ILE ALA VAL VAL SER VAL
SEQRES 26 D 804 LYS VAL PRO ASP PRO LYS PHE SER SER GLN THR LYS ASP
SEQRES 27 D 804 LYS LEU VAL SER SER GLU VAL LYS SER ALA VAL GLU GLN
SEQRES 28 D 804 GLN MET ASN GLU LEU LEU ALA GLU TYR LEU LEU GLU ASN
SEQRES 29 D 804 PRO THR ASP ALA LYS ILE VAL VAL GLY LYS ILE ILE ASP
SEQRES 30 D 804 ALA ALA ARG ALA ARG GLU ALA ALA ARG ARG ALA ARG GLU
SEQRES 31 D 804 MET THR ARG ARG LYS GLY ALA LEU ASP LEU ALA GLY LEU
SEQRES 32 D 804 PRO GLY LYS LEU ALA ASP CYS GLN GLU ARG ASP PRO ALA
SEQRES 33 D 804 LEU SER GLU LEU TYR LEU VAL GLU GLY ASP SER ALA GLY
SEQRES 34 D 804 GLY SER ALA LYS GLN GLY ARG ASN ARG LYS ASN GLN ALA
SEQRES 35 D 804 ILE LEU PRO LEU LYS GLY LYS ILE LEU ASN VAL GLU LYS
SEQRES 36 D 804 ALA ARG PHE ASP LYS MET LEU SER SER GLN GLU VAL ALA
SEQRES 37 D 804 THR LEU ILE THR ALA LEU GLY CYS GLY ILE GLY ARG ASP
SEQRES 38 D 804 GLU TYR ASN PRO ASP LYS LEU ARG TYR HIS SER ILE ILE
SEQRES 39 D 804 ILE MET THR ASP ALA ASP VAL ASP GLY SER HIS ILE ARG
SEQRES 40 D 804 THR LEU LEU LEU THR PHE PHE TYR ARG GLN MET PRO GLU
SEQRES 41 D 804 ILE VAL GLU ARG GLY HIS VAL TYR ILE ALA GLN PRO PRO
SEQRES 42 D 804 LEU TYR LYS VAL LYS LYS GLY LYS GLN GLU GLN TYR ILE
SEQRES 43 D 804 LYS ASP ASP GLU ALA MET ASP GLN TYR GLN ILE SER ILE
SEQRES 44 D 804 ALA LEU ASP GLY ALA THR LEU HIS THR ASN ALA SER ALA
SEQRES 45 D 804 PRO ALA LEU ALA GLY GLU ALA LEU GLU LYS LEU VAL SER
SEQRES 46 D 804 GLU TYR ASN ALA THR GLN LYS MET ILE ASN ARG MET GLU
SEQRES 47 D 804 ARG ARG TYR PRO LYS ALA MET LEU LYS GLU LEU ILE TYR
SEQRES 48 D 804 GLN PRO THR LEU THR GLU ALA ASP LEU SER ASP GLU GLN
SEQRES 49 D 804 THR VAL THR ARG TRP VAL ASN ALA LEU VAL SER GLU LEU
SEQRES 50 D 804 ASN ASP LYS GLU GLN HIS GLY SER GLN TRP LYS PHE ASP
SEQRES 51 D 804 VAL HIS THR ASN ALA GLU GLN ASN LEU PHE GLU PRO ILE
SEQRES 52 D 804 VAL ARG VAL ARG THR HIS GLY VAL ASP THR ASP TYR PRO
SEQRES 53 D 804 LEU ASP HIS GLU PHE ILE THR GLY GLY GLU TYR ARG ARG
SEQRES 54 D 804 ILE CYS THR LEU GLY GLU LYS LEU ARG GLY LEU LEU GLU
SEQRES 55 D 804 GLU ASP ALA PHE ILE GLU ARG GLY GLU ARG ARG GLN PRO
SEQRES 56 D 804 VAL ALA SER PHE GLU GLN ALA LEU ASP TRP LEU VAL LYS
SEQRES 57 D 804 GLU SER ARG ARG GLY LEU SER ILE GLN ARG TYR LYS GLY
SEQRES 58 D 804 LEU GLY GLU MET ASN PRO GLU GLN LEU TRP GLU THR THR
SEQRES 59 D 804 MET ASP PRO GLU SER ARG ARG MET LEU ARG VAL THR VAL
SEQRES 60 D 804 LYS ASP ALA ILE ALA ALA ASP GLN LEU PHE THR THR LEU
SEQRES 61 D 804 MET GLY ASP ALA VAL GLU PRO ARG ARG ALA PHE ILE GLU
SEQRES 62 D 804 GLU ASN ALA LEU LYS ALA ALA ASN ILE ASP ILE
SEQRES 1 F 14 DA DT DC DA DT DA DA DG DC DC DG DT DA
SEQRES 2 F 14 DG
SEQRES 1 E 14 DA DT DC DA DT DA DA DG DC DC DG DT DA
SEQRES 2 E 14 DG
SEQRES 1 G 18 DG DT DA DC DC DT DA DC DG DG DC DT DT
SEQRES 2 G 18 DA DT DG DA DT
SEQRES 1 H 18 DG DT DA DC DC DT DA DC DG DG DC DT DT
SEQRES 2 H 18 DA DT DG DA DT
HET JHN G 101 66
HETNAM JHN (3~{R})-3-[[4-(3,4-DIHYDRO-2~{H}-PYRANO[2,3-C]PYRIDIN-
HETNAM 2 JHN 6-YLMETHYLAMINO)PIPERIDIN-1-YL]METHYL]-1,4,7-
HETNAM 3 JHN TRIAZATRICYCLO[6.3.1.0^{4,12}]DODECA-6,8(12),9-TRIENE-
HETNAM 4 JHN 5,11-DIONE
FORMUL 9 JHN C24 H28 N6 O3
HELIX 1 AA1 GLU A 15 ARG A 32 1 18
HELIX 2 AA2 LYS A 42 GLY A 56 1 15
HELIX 3 AA3 SER A 66 TYR A 77 1 12
HELIX 4 AA4 ASP A 82 GLN A 94 1 13
HELIX 5 AA5 PRO A 95 LEU A 98 5 4
HELIX 6 AA6 ILE A 130 MET A 135 1 6
HELIX 7 AA7 PRO A 164 ASN A 169 1 6
HELIX 8 AA8 ASN A 186 ASP A 200 1 15
HELIX 9 AA9 SER A 204 ILE A 212 1 9
HELIX 10 AB1 GLY A 225 THR A 235 1 11
HELIX 11 AB2 ASN A 269 GLU A 283 1 15
HELIX 12 AB3 GLY A 313 THR A 324 1 12
HELIX 13 AB4 ASN A 346 ASN A 389 1 44
HELIX 14 AB5 ILE A 390 ALA A 400 1 11
HELIX 15 AB6 THR A 402 ASN A 413 1 12
HELIX 16 AB7 GLY A 418 ALA A 422 5 5
HELIX 17 AB8 THR A 451 ASP A 460 1 10
HELIX 18 AB9 LEU A 469 SER A 494 1 26
HELIX 19 AC1 SER A 494 GLY A 514 1 21
HELIX 20 AC2 GLY B 425 ARG B 436 1 12
HELIX 21 AC3 GLN B 465 THR B 472 1 8
HELIX 22 AC4 ASP B 500 MET B 518 1 19
HELIX 23 AC5 MET B 518 ARG B 524 1 7
HELIX 24 AC6 ASP B 548 LEU B 561 1 14
HELIX 25 AC7 GLY B 577 GLU B 598 1 22
HELIX 26 AC8 PRO B 602 LEU B 609 1 8
HELIX 27 AC9 THR B 616 SER B 621 5 6
HELIX 28 AD1 ASP B 622 GLU B 641 1 20
HELIX 29 AD2 ASP B 678 GLY B 684 1 7
HELIX 30 AD3 GLY B 684 GLY B 699 1 16
HELIX 31 AD4 SER B 718 ARG B 732 1 15
HELIX 32 AD5 GLY B 741 MET B 745 5 5
HELIX 33 AD6 ASN B 746 MET B 755 1 10
HELIX 34 AD7 ALA B 772 PHE B 777 1 6
HELIX 35 AD8 LEU B 780 GLU B 786 1 7
HELIX 36 AD9 GLU C 15 ARG C 32 1 18
HELIX 37 AE1 LYS C 42 GLY C 56 1 15
HELIX 38 AE2 SER C 66 TYR C 77 1 12
HELIX 39 AE3 ASP C 82 GLN C 94 1 13
HELIX 40 AE4 PRO C 95 LEU C 98 5 4
HELIX 41 AE5 ILE C 130 MET C 135 1 6
HELIX 42 AE6 PRO C 164 ASN C 169 1 6
HELIX 43 AE7 ASN C 186 ASP C 200 1 15
HELIX 44 AE8 SER C 204 ILE C 212 1 9
HELIX 45 AE9 GLY C 225 THR C 235 1 11
HELIX 46 AF1 ASN C 269 GLU C 283 1 15
HELIX 47 AF2 GLY C 313 THR C 324 1 12
HELIX 48 AF3 ASN C 346 ASN C 389 1 44
HELIX 49 AF4 ILE C 390 ALA C 400 1 11
HELIX 50 AF5 THR C 402 ASN C 413 1 12
HELIX 51 AF6 GLY C 418 ALA C 422 5 5
HELIX 52 AF7 THR C 451 ASP C 460 1 10
HELIX 53 AF8 LEU C 469 SER C 494 1 26
HELIX 54 AF9 SER C 494 GLY C 514 1 21
HELIX 55 AG1 GLY D 425 ARG D 436 1 12
HELIX 56 AG2 GLN D 465 THR D 472 1 8
HELIX 57 AG3 ASP D 500 MET D 518 1 19
HELIX 58 AG4 MET D 518 ARG D 524 1 7
HELIX 59 AG5 ASP D 548 LEU D 561 1 14
HELIX 60 AG6 GLY D 577 GLU D 598 1 22
HELIX 61 AG7 PRO D 602 LEU D 609 1 8
HELIX 62 AG8 THR D 616 SER D 621 5 6
HELIX 63 AG9 ASP D 622 GLU D 641 1 20
HELIX 64 AH1 ASP D 678 GLY D 684 1 7
HELIX 65 AH2 GLY D 684 GLY D 699 1 16
HELIX 66 AH3 SER D 718 ARG D 732 1 15
HELIX 67 AH4 GLY D 741 MET D 745 5 5
HELIX 68 AH5 ASN D 746 MET D 755 1 10
HELIX 69 AH6 ALA D 772 PHE D 777 1 6
HELIX 70 AH7 LEU D 780 GLU D 786 1 7
SHEET 1 AA1 3 LYS A 64 LYS A 65 0
SHEET 2 AA1 3 GLU A 124 LEU A 127 -1 O ILE A 125 N LYS A 64
SHEET 3 AA1 3 VAL A 103 GLN A 106 -1 N GLN A 106 O GLU A 124
SHEET 1 AA2 2 PHE A 145 ASP A 147 0
SHEET 2 AA2 2 LYS A 154 PRO A 156 -1 O ILE A 155 N VAL A 146
SHEET 1 AA3 4 GLN A 327 ASN A 333 0
SHEET 2 AA3 4 ARG A 237 ARG A 243 -1 N ILE A 242 O VAL A 328
SHEET 3 AA3 4 ILE A 222 ILE A 223 -1 N ILE A 222 O ARG A 243
SHEET 4 AA3 4 GLU A 520 ILE A 521 1 O GLU A 520 N ILE A 223
SHEET 1 AA4 4 ARG A 245 VAL A 250 0
SHEET 2 AA4 4 GLU A 257 GLU A 263 -1 O THR A 258 N GLU A 249
SHEET 3 AA4 4 ILE A 303 VAL A 307 -1 O ILE A 305 N ILE A 259
SHEET 4 AA4 4 ILE A 289 ASP A 294 -1 N SER A 290 O GLU A 306
SHEET 1 AA5 2 VAL A 335 LEU A 337 0
SHEET 2 AA5 2 PRO A 342 ILE A 344 -1 O LYS A 343 N ALA A 336
SHEET 1 AA6 4 GLN B 441 LEU B 446 0
SHEET 2 AA6 4 GLU B 419 GLU B 424 1 N TYR B 421 O LEU B 444
SHEET 3 AA6 4 ILE B 493 ILE B 495 1 O ILE B 494 N LEU B 420
SHEET 4 AA6 4 VAL B 527 ILE B 529 1 O TYR B 528 N ILE B 495
SHEET 1 AA7 3 GLN B 542 ILE B 546 0
SHEET 2 AA7 3 TYR B 535 LYS B 539 -1 N TYR B 535 O ILE B 546
SHEET 3 AA7 3 SER B 735 ARG B 738 -1 O GLN B 737 N LYS B 536
SHEET 1 AA8 3 LEU B 575 ALA B 576 0
SHEET 2 AA8 3 THR B 565 LEU B 566 -1 N LEU B 566 O LEU B 575
SHEET 3 AA8 3 ILE B 707 GLU B 708 -1 O GLU B 708 N THR B 565
SHEET 1 AA9 3 GLN B 646 THR B 653 0
SHEET 2 AA9 3 PHE B 660 ARG B 667 -1 O ARG B 665 N LYS B 648
SHEET 3 AA9 3 ASP B 672 PRO B 676 -1 O THR B 673 N VAL B 666
SHEET 1 AB1 3 LYS C 64 LYS C 65 0
SHEET 2 AB1 3 GLU C 124 LEU C 127 -1 O ILE C 125 N LYS C 64
SHEET 3 AB1 3 VAL C 103 GLN C 106 -1 N GLN C 106 O GLU C 124
SHEET 1 AB2 2 PHE C 145 ASP C 147 0
SHEET 2 AB2 2 LYS C 154 PRO C 156 -1 O ILE C 155 N VAL C 146
SHEET 1 AB3 4 GLN C 327 ASN C 333 0
SHEET 2 AB3 4 ARG C 237 ARG C 243 -1 N ILE C 242 O VAL C 328
SHEET 3 AB3 4 ILE C 222 ILE C 223 -1 N ILE C 222 O ARG C 243
SHEET 4 AB3 4 GLU C 520 ILE C 521 1 O GLU C 520 N ILE C 223
SHEET 1 AB4 4 ARG C 245 VAL C 250 0
SHEET 2 AB4 4 GLU C 257 GLU C 263 -1 O THR C 258 N GLU C 249
SHEET 3 AB4 4 ILE C 303 VAL C 307 -1 O ILE C 305 N ILE C 259
SHEET 4 AB4 4 ILE C 289 ASP C 294 -1 N SER C 290 O GLU C 306
SHEET 1 AB5 2 VAL C 335 LEU C 337 0
SHEET 2 AB5 2 PRO C 342 ILE C 344 -1 O LYS C 343 N ALA C 336
SHEET 1 AB6 4 GLN D 441 LEU D 446 0
SHEET 2 AB6 4 GLU D 419 GLU D 424 1 N TYR D 421 O LEU D 444
SHEET 3 AB6 4 ILE D 493 ILE D 495 1 O ILE D 494 N LEU D 420
SHEET 4 AB6 4 VAL D 527 ILE D 529 1 O TYR D 528 N ILE D 495
SHEET 1 AB7 3 GLN D 542 ILE D 546 0
SHEET 2 AB7 3 TYR D 535 LYS D 539 -1 N TYR D 535 O ILE D 546
SHEET 3 AB7 3 SER D 735 ARG D 738 -1 O GLN D 737 N LYS D 536
SHEET 1 AB8 3 LEU D 575 ALA D 576 0
SHEET 2 AB8 3 THR D 565 LEU D 566 -1 N LEU D 566 O LEU D 575
SHEET 3 AB8 3 ILE D 707 GLU D 708 -1 O GLU D 708 N THR D 565
SHEET 1 AB9 3 GLN D 646 THR D 653 0
SHEET 2 AB9 3 PHE D 660 ARG D 667 -1 O ARG D 665 N LYS D 648
SHEET 3 AB9 3 ASP D 672 PRO D 676 -1 O THR D 673 N VAL D 666
CISPEP 1 ARG B 709 GLY B 710 0 -7.54
CISPEP 2 ARG D 709 GLY D 710 0 -7.62
SITE 1 AC1 8 ASP A 82 MET A 120 ASP C 82 MET C 120
SITE 2 AC1 8 DT G 16 DA G 17 DT H 16 DA H 17
CRYST1 1.000 1.000 1.000 90.00 90.00 90.00 P 1 1
ORIGX1 1.000000 0.000000 0.000000 0.00000
ORIGX2 0.000000 1.000000 0.000000 0.00000
ORIGX3 0.000000 0.000000 1.000000 0.00000
SCALE1 1.000000 0.000000 0.000000 0.00000
SCALE2 0.000000 1.000000 0.000000 0.00000
SCALE3 0.000000 0.000000 1.000000 0.00000
(ATOM LINES ARE NOT SHOWN.)
END