GenomeNet

Database: PDB
Entry: 6RVD
LinkDB: 6RVD
Original site: 6RVD 
HEADER    MEMBRANE PROTEIN                        31-MAY-19   6RVD              
TITLE     REVISED CRYO-EM STRUCTURE OF THE HUMAN 2:1 PTCH1-SHH COMPLEX          
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: PROTEIN PATCHED HOMOLOG 1;                                 
COMPND   3 CHAIN: A, B;                                                         
COMPND   4 SYNONYM: PTC1;                                                       
COMPND   5 ENGINEERED: YES;                                                     
COMPND   6 MOL_ID: 2;                                                           
COMPND   7 MOLECULE: SONIC HEDGEHOG PROTEIN;                                    
COMPND   8 CHAIN: C;                                                            
COMPND   9 SYNONYM: SHH,HHG-1,SHH UNPROCESSED N-TERMINAL SIGNALING AND C-       
COMPND  10 TERMINAL AUTOPROCESSING DOMAINS,SHHNC;                               
COMPND  11 ENGINEERED: YES;                                                     
COMPND  12 OTHER_DETAILS: HUMAN SHH N-TERMINAL SIGNALLING DOMAIN, N-TERMINALLY  
COMPND  13 PALMITOYLATED AND C-TERMINALLY CHOLESTEROLYLATED.                    
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   3 ORGANISM_COMMON: HUMAN;                                              
SOURCE   4 ORGANISM_TAXID: 9606;                                                
SOURCE   5 GENE: PTCH1, PTCH;                                                   
SOURCE   6 EXPRESSION_SYSTEM: HOMO SAPIENS;                                     
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 9606;                                       
SOURCE   8 MOL_ID: 2;                                                           
SOURCE   9 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  10 ORGANISM_COMMON: HUMAN;                                              
SOURCE  11 ORGANISM_TAXID: 9606;                                                
SOURCE  12 GENE: SHH;                                                           
SOURCE  13 EXPRESSION_SYSTEM: HOMO SAPIENS;                                     
SOURCE  14 EXPRESSION_SYSTEM_TAXID: 9606                                        
KEYWDS    ---- HEDGEHOG MORPHOGEN RECEPTOR, RECEPTOR-NANOBODY COMPLEX,          
KEYWDS   2 CHOLESTEROL, PALMITATE, LIPID-PROTEIN-MODIFICATION, MEMBRANE PROTEIN 
EXPDTA    ELECTRON MICROSCOPY                                                   
AUTHOR    K.EL OMARI,A.F.RUDOLF,C.KOWATSCH,T.MALINAUSKAS,M.KINNEBREW,           
AUTHOR   2 T.B.ANSELL,B.BISHOP,E.PARDON,R.A.SCHWAB,M.QIAN,R.DUMAN,D.F.COVEY,    
AUTHOR   3 J.STEYAERT,A.WAGNER,M.S.P.SANSOM,R.ROHATGI,C.SIEBOLD                 
REVDAT   4   29-JUL-20 6RVD    1       COMPND REMARK HETNAM LINK                
REVDAT   4 2                   1       SITE   ATOM                              
REVDAT   3   18-DEC-19 6RVD    1       CRYST1 SCALE                             
REVDAT   2   09-OCT-19 6RVD    1       JRNL                                     
REVDAT   1   02-OCT-19 6RVD    0                                                
JRNL        AUTH   A.F.RUDOLF,M.KINNEBREW,C.KOWATSCH,T.B.ANSELL,K.EL OMARI,     
JRNL        AUTH 2 B.BISHOP,E.PARDON,R.A.SCHWAB,T.MALINAUSKAS,M.QIAN,R.DUMAN,   
JRNL        AUTH 3 D.F.COVEY,J.STEYAERT,A.WAGNER,M.S.P.SANSOM,R.ROHATGI,        
JRNL        AUTH 4 C.SIEBOLD                                                    
JRNL        TITL   THE MORPHOGEN SONIC HEDGEHOG INHIBITS ITS RECEPTOR PATCHED   
JRNL        TITL 2 BY A PINCER GRASP MECHANISM.                                 
JRNL        REF    NAT.CHEM.BIOL.                V.  15   975 2019              
JRNL        REFN                   ESSN 1552-4469                               
JRNL        PMID   31548691                                                     
JRNL        DOI    10.1038/S41589-019-0370-Y                                    
REMARK   2                                                                      
REMARK   2 RESOLUTION.    3.50 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   SOFTWARE PACKAGES      : RELION, CTFFIND, COOT, PHENIX             
REMARK   3   RECONSTRUCTION SCHEMA  : NULL                                      
REMARK   3                                                                      
REMARK   3 EM MAP-MODEL FITTING AND REFINEMENT                                  
REMARK   3   PDB ENTRY                    : 6E1H                                
REMARK   3   REFINEMENT SPACE             : REAL                                
REMARK   3   REFINEMENT PROTOCOL          : AB INITIO MODEL                     
REMARK   3   REFINEMENT TARGET            : NULL                                
REMARK   3   OVERALL ANISOTROPIC B VALUE  : NULL                                
REMARK   3                                                                      
REMARK   3 FITTING PROCEDURE : THIS IS A RE-REFINEMENT OF PDB ENTRY 6E1H,       
REMARK   3  ALSO USING THE HIGH-RESOLUTION CRYSTAL STRUCTURES OF THE            
REMARK   3  ISOLATED PTCH1-ECD1 (PDB 6RTW) AND PTCH1-ECD2 (PDB 6RVC).           
REMARK   3                                                                      
REMARK   3 EM IMAGE RECONSTRUCTION STATISTICS                                   
REMARK   3   NOMINAL PIXEL SIZE (ANGSTROMS)    : NULL                           
REMARK   3   ACTUAL PIXEL SIZE  (ANGSTROMS)    : NULL                           
REMARK   3   EFFECTIVE RESOLUTION (ANGSTROMS)  : 3.500                          
REMARK   3   NUMBER OF PARTICLES               : 77712                          
REMARK   3   CTF CORRECTION METHOD             : NONE                           
REMARK   3                                                                      
REMARK   3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL                    
REMARK   3                                                                      
REMARK   3 OTHER DETAILS: NULL                                                  
REMARK   4                                                                      
REMARK   4 6RVD COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 31-MAY-19.                  
REMARK 100 THE DEPOSITION ID IS D_1292102581.                                   
REMARK 245                                                                      
REMARK 245 EXPERIMENTAL DETAILS                                                 
REMARK 245   RECONSTRUCTION METHOD          : SINGLE PARTICLE                   
REMARK 245   SPECIMEN TYPE                  : NULL                              
REMARK 245                                                                      
REMARK 245 ELECTRON MICROSCOPE SAMPLE                                           
REMARK 245   SAMPLE TYPE                    : PARTICLE                          
REMARK 245   PARTICLE TYPE                  : POINT                             
REMARK 245   NAME OF SAMPLE                 : 2:1 PTCH1:SHH COMPLEX             
REMARK 245   SAMPLE CONCENTRATION (MG ML-1) : 5.00                              
REMARK 245   SAMPLE SUPPORT DETAILS         : NULL                              
REMARK 245   SAMPLE VITRIFICATION DETAILS   : NULL                              
REMARK 245   SAMPLE BUFFER                  : NULL                              
REMARK 245   PH                             : 7.50                              
REMARK 245   SAMPLE DETAILS                 : 2:1 PATCHED-1 (PTCH1):SHH         
REMARK 245  COMPLEX                                                             
REMARK 245                                                                      
REMARK 245 DATA ACQUISITION                                                     
REMARK 245   DATE OF EXPERIMENT                : NULL                           
REMARK 245   NUMBER OF MICROGRAPHS-IMAGES      : NULL                           
REMARK 245   TEMPERATURE (KELVIN)              : NULL                           
REMARK 245   MICROSCOPE MODEL                  : FEI TITAN KRIOS                
REMARK 245   DETECTOR TYPE                     : GATAN K2 BASE (4K X 4K)        
REMARK 245   MINIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MAXIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MINIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   MAXIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   NOMINAL CS                        : NULL                           
REMARK 245   IMAGING MODE                      : DARK FIELD                     
REMARK 245   ELECTRON DOSE (ELECTRONS NM**-2)  : 1.60                           
REMARK 245   ILLUMINATION MODE                 : OTHER                          
REMARK 245   NOMINAL MAGNIFICATION             : NULL                           
REMARK 245   CALIBRATED MAGNIFICATION          : NULL                           
REMARK 245   SOURCE                            : FIELD EMISSION GUN             
REMARK 245   ACCELERATION VOLTAGE (KV)         : 300                            
REMARK 245   IMAGING DETAILS                   : NULL                           
REMARK 247                                                                      
REMARK 247 ELECTRON MICROSCOPY                                                  
REMARK 247  THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON          
REMARK 247  MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE              
REMARK 247  THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES           
REMARK 247  ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION         
REMARK 247  OF THE STRUCTURE FACTORS.                                           
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: TRIMERIC                          
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: TRIMERIC                   
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 12940 ANGSTROM**2                         
REMARK 350 SURFACE AREA OF THE COMPLEX: 89810 ANGSTROM**2                       
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -47.0 KCAL/MOL                        
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D                            
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     MET A     1                                                      
REMARK 465     ALA A     2                                                      
REMARK 465     SER A     3                                                      
REMARK 465     ALA A     4                                                      
REMARK 465     GLY A     5                                                      
REMARK 465     ASN A     6                                                      
REMARK 465     ALA A     7                                                      
REMARK 465     ALA A     8                                                      
REMARK 465     GLU A     9                                                      
REMARK 465     PRO A    10                                                      
REMARK 465     GLN A    11                                                      
REMARK 465     ASP A    12                                                      
REMARK 465     ARG A    13                                                      
REMARK 465     GLY A    14                                                      
REMARK 465     GLY A    15                                                      
REMARK 465     GLY A    16                                                      
REMARK 465     GLY A    17                                                      
REMARK 465     SER A    18                                                      
REMARK 465     GLY A    19                                                      
REMARK 465     CYS A    20                                                      
REMARK 465     ILE A    21                                                      
REMARK 465     GLY A    22                                                      
REMARK 465     ALA A    23                                                      
REMARK 465     PRO A    24                                                      
REMARK 465     GLY A    25                                                      
REMARK 465     ARG A    26                                                      
REMARK 465     PRO A    27                                                      
REMARK 465     ALA A    28                                                      
REMARK 465     GLY A    29                                                      
REMARK 465     GLY A    30                                                      
REMARK 465     GLY A    31                                                      
REMARK 465     ARG A    32                                                      
REMARK 465     ARG A    33                                                      
REMARK 465     ARG A    34                                                      
REMARK 465     ARG A    35                                                      
REMARK 465     THR A    36                                                      
REMARK 465     GLY A    37                                                      
REMARK 465     GLY A    38                                                      
REMARK 465     LEU A    39                                                      
REMARK 465     ARG A    40                                                      
REMARK 465     ARG A    41                                                      
REMARK 465     ALA A    42                                                      
REMARK 465     ALA A    43                                                      
REMARK 465     ALA A    44                                                      
REMARK 465     PRO A    45                                                      
REMARK 465     ASP A    46                                                      
REMARK 465     ARG A    47                                                      
REMARK 465     ASP A    48                                                      
REMARK 465     TYR A    49                                                      
REMARK 465     LEU A    50                                                      
REMARK 465     HIS A    51                                                      
REMARK 465     ARG A    52                                                      
REMARK 465     PRO A    53                                                      
REMARK 465     SER A    54                                                      
REMARK 465     TYR A    55                                                      
REMARK 465     CYS A    56                                                      
REMARK 465     ASP A    57                                                      
REMARK 465     ALA A    58                                                      
REMARK 465     ALA A    59                                                      
REMARK 465     PHE A    60                                                      
REMARK 465     ALA A    61                                                      
REMARK 465     LEU A    62                                                      
REMARK 465     GLU A    63                                                      
REMARK 465     GLN A    64                                                      
REMARK 465     ILE A    65                                                      
REMARK 465     SER A    66                                                      
REMARK 465     LYS A    67                                                      
REMARK 465     GLY A    68                                                      
REMARK 465     LYS A    69                                                      
REMARK 465     ALA A    70                                                      
REMARK 465     THR A    71                                                      
REMARK 465     ASP A   609                                                      
REMARK 465     ILE A   610                                                      
REMARK 465     PHE A   611                                                      
REMARK 465     CYS A   612                                                      
REMARK 465     CYS A   613                                                      
REMARK 465     PHE A   614                                                      
REMARK 465     THR A   615                                                      
REMARK 465     SER A   616                                                      
REMARK 465     PRO A   617                                                      
REMARK 465     CYS A   618                                                      
REMARK 465     VAL A   619                                                      
REMARK 465     SER A   620                                                      
REMARK 465     ARG A   621                                                      
REMARK 465     VAL A   622                                                      
REMARK 465     ILE A   623                                                      
REMARK 465     GLN A   624                                                      
REMARK 465     VAL A   625                                                      
REMARK 465     GLU A   626                                                      
REMARK 465     PRO A   627                                                      
REMARK 465     GLN A   628                                                      
REMARK 465     ALA A   629                                                      
REMARK 465     TYR A   630                                                      
REMARK 465     THR A   631                                                      
REMARK 465     ASP A   632                                                      
REMARK 465     THR A   633                                                      
REMARK 465     HIS A   634                                                      
REMARK 465     ASP A   635                                                      
REMARK 465     ASN A   636                                                      
REMARK 465     THR A   637                                                      
REMARK 465     ARG A   638                                                      
REMARK 465     TYR A   639                                                      
REMARK 465     SER A   640                                                      
REMARK 465     PRO A   641                                                      
REMARK 465     PRO A   642                                                      
REMARK 465     PRO A   643                                                      
REMARK 465     PRO A   644                                                      
REMARK 465     TYR A   645                                                      
REMARK 465     SER A   646                                                      
REMARK 465     SER A   647                                                      
REMARK 465     HIS A   648                                                      
REMARK 465     SER A   649                                                      
REMARK 465     PHE A   650                                                      
REMARK 465     ALA A   651                                                      
REMARK 465     HIS A   652                                                      
REMARK 465     GLU A   653                                                      
REMARK 465     THR A   654                                                      
REMARK 465     GLN A   655                                                      
REMARK 465     ILE A   656                                                      
REMARK 465     THR A   657                                                      
REMARK 465     MET A   658                                                      
REMARK 465     GLN A   659                                                      
REMARK 465     SER A   660                                                      
REMARK 465     THR A   661                                                      
REMARK 465     VAL A   662                                                      
REMARK 465     GLN A   663                                                      
REMARK 465     LEU A   664                                                      
REMARK 465     ARG A   665                                                      
REMARK 465     THR A   666                                                      
REMARK 465     GLU A   667                                                      
REMARK 465     TYR A   668                                                      
REMARK 465     ASP A   669                                                      
REMARK 465     PRO A   670                                                      
REMARK 465     HIS A   671                                                      
REMARK 465     THR A   672                                                      
REMARK 465     HIS A   673                                                      
REMARK 465     VAL A   674                                                      
REMARK 465     TYR A   675                                                      
REMARK 465     TYR A   676                                                      
REMARK 465     THR A   677                                                      
REMARK 465     THR A   678                                                      
REMARK 465     ALA A   679                                                      
REMARK 465     GLU A   680                                                      
REMARK 465     PRO A   681                                                      
REMARK 465     ARG A   682                                                      
REMARK 465     SER A   683                                                      
REMARK 465     GLU A   684                                                      
REMARK 465     ILE A   685                                                      
REMARK 465     SER A   686                                                      
REMARK 465     VAL A   687                                                      
REMARK 465     GLN A   688                                                      
REMARK 465     PRO A   689                                                      
REMARK 465     VAL A   690                                                      
REMARK 465     THR A   691                                                      
REMARK 465     VAL A   692                                                      
REMARK 465     THR A   693                                                      
REMARK 465     GLN A   694                                                      
REMARK 465     ASP A   695                                                      
REMARK 465     THR A   696                                                      
REMARK 465     LEU A   697                                                      
REMARK 465     SER A   698                                                      
REMARK 465     CYS A   699                                                      
REMARK 465     GLN A   700                                                      
REMARK 465     SER A   701                                                      
REMARK 465     PRO A   702                                                      
REMARK 465     GLU A   703                                                      
REMARK 465     SER A   704                                                      
REMARK 465     THR A   705                                                      
REMARK 465     SER A   706                                                      
REMARK 465     SER A   707                                                      
REMARK 465     THR A   708                                                      
REMARK 465     ARG A   709                                                      
REMARK 465     ASP A   710                                                      
REMARK 465     LEU A   711                                                      
REMARK 465     LEU A   712                                                      
REMARK 465     SER A   713                                                      
REMARK 465     GLN A   714                                                      
REMARK 465     PHE A   715                                                      
REMARK 465     SER A   716                                                      
REMARK 465     ASP A   717                                                      
REMARK 465     SER A   718                                                      
REMARK 465     SER A   719                                                      
REMARK 465     LEU A   720                                                      
REMARK 465     HIS A   721                                                      
REMARK 465     CYS A   722                                                      
REMARK 465     LEU A   723                                                      
REMARK 465     GLU A   724                                                      
REMARK 465     PRO A   725                                                      
REMARK 465     PRO A   726                                                      
REMARK 465     CYS A   727                                                      
REMARK 465     THR A   728                                                      
REMARK 465     LYS A   729                                                      
REMARK 465     TRP A   730                                                      
REMARK 465     THR A   731                                                      
REMARK 465     TYR A  1181                                                      
REMARK 465     PRO A  1182                                                      
REMARK 465     GLU A  1183                                                      
REMARK 465     VAL A  1184                                                      
REMARK 465     SER A  1185                                                      
REMARK 465     PRO A  1186                                                      
REMARK 465     ALA A  1187                                                      
REMARK 465     ASN A  1188                                                      
REMARK 465     GLY A  1189                                                      
REMARK 465     LEU A  1190                                                      
REMARK 465     ASN A  1191                                                      
REMARK 465     ARG A  1192                                                      
REMARK 465     LEU A  1193                                                      
REMARK 465     PRO A  1194                                                      
REMARK 465     THR A  1195                                                      
REMARK 465     PRO A  1196                                                      
REMARK 465     SER A  1197                                                      
REMARK 465     PRO A  1198                                                      
REMARK 465     GLU A  1199                                                      
REMARK 465     PRO A  1200                                                      
REMARK 465     PRO A  1201                                                      
REMARK 465     PRO A  1202                                                      
REMARK 465     SER A  1203                                                      
REMARK 465     VAL A  1204                                                      
REMARK 465     VAL A  1205                                                      
REMARK 465     ARG A  1206                                                      
REMARK 465     PHE A  1207                                                      
REMARK 465     ALA A  1208                                                      
REMARK 465     MET A  1209                                                      
REMARK 465     PRO A  1210                                                      
REMARK 465     PRO A  1211                                                      
REMARK 465     GLY A  1212                                                      
REMARK 465     HIS A  1213                                                      
REMARK 465     THR A  1214                                                      
REMARK 465     HIS A  1215                                                      
REMARK 465     SER A  1216                                                      
REMARK 465     GLY A  1217                                                      
REMARK 465     SER A  1218                                                      
REMARK 465     ASP A  1219                                                      
REMARK 465     SER A  1220                                                      
REMARK 465     SER A  1221                                                      
REMARK 465     ASP A  1222                                                      
REMARK 465     SER A  1223                                                      
REMARK 465     GLU A  1224                                                      
REMARK 465     TYR A  1225                                                      
REMARK 465     SER A  1226                                                      
REMARK 465     SER A  1227                                                      
REMARK 465     GLN A  1228                                                      
REMARK 465     THR A  1229                                                      
REMARK 465     THR A  1230                                                      
REMARK 465     VAL A  1231                                                      
REMARK 465     SER A  1232                                                      
REMARK 465     GLY A  1233                                                      
REMARK 465     LEU A  1234                                                      
REMARK 465     SER A  1235                                                      
REMARK 465     GLU A  1236                                                      
REMARK 465     GLU A  1237                                                      
REMARK 465     LEU A  1238                                                      
REMARK 465     ARG A  1239                                                      
REMARK 465     HIS A  1240                                                      
REMARK 465     TYR A  1241                                                      
REMARK 465     GLU A  1242                                                      
REMARK 465     ALA A  1243                                                      
REMARK 465     GLN A  1244                                                      
REMARK 465     GLN A  1245                                                      
REMARK 465     GLY A  1246                                                      
REMARK 465     ALA A  1247                                                      
REMARK 465     GLY A  1248                                                      
REMARK 465     GLY A  1249                                                      
REMARK 465     PRO A  1250                                                      
REMARK 465     ALA A  1251                                                      
REMARK 465     HIS A  1252                                                      
REMARK 465     GLN A  1253                                                      
REMARK 465     VAL A  1254                                                      
REMARK 465     ILE A  1255                                                      
REMARK 465     VAL A  1256                                                      
REMARK 465     GLU A  1257                                                      
REMARK 465     ALA A  1258                                                      
REMARK 465     THR A  1259                                                      
REMARK 465     GLU A  1260                                                      
REMARK 465     ASN A  1261                                                      
REMARK 465     PRO A  1262                                                      
REMARK 465     VAL A  1263                                                      
REMARK 465     PHE A  1264                                                      
REMARK 465     ALA A  1265                                                      
REMARK 465     HIS A  1266                                                      
REMARK 465     SER A  1267                                                      
REMARK 465     THR A  1268                                                      
REMARK 465     VAL A  1269                                                      
REMARK 465     VAL A  1270                                                      
REMARK 465     HIS A  1271                                                      
REMARK 465     PRO A  1272                                                      
REMARK 465     GLU A  1273                                                      
REMARK 465     SER A  1274                                                      
REMARK 465     ARG A  1275                                                      
REMARK 465     HIS A  1276                                                      
REMARK 465     HIS A  1277                                                      
REMARK 465     PRO A  1278                                                      
REMARK 465     PRO A  1279                                                      
REMARK 465     SER A  1280                                                      
REMARK 465     ASN A  1281                                                      
REMARK 465     PRO A  1282                                                      
REMARK 465     ARG A  1283                                                      
REMARK 465     GLN A  1284                                                      
REMARK 465     GLN A  1285                                                      
REMARK 465     PRO A  1286                                                      
REMARK 465     HIS A  1287                                                      
REMARK 465     LEU A  1288                                                      
REMARK 465     ASP A  1289                                                      
REMARK 465     SER A  1290                                                      
REMARK 465     GLY A  1291                                                      
REMARK 465     SER A  1292                                                      
REMARK 465     LEU A  1293                                                      
REMARK 465     PRO A  1294                                                      
REMARK 465     PRO A  1295                                                      
REMARK 465     GLY A  1296                                                      
REMARK 465     ARG A  1297                                                      
REMARK 465     GLN A  1298                                                      
REMARK 465     GLY A  1299                                                      
REMARK 465     GLN A  1300                                                      
REMARK 465     GLN A  1301                                                      
REMARK 465     PRO A  1302                                                      
REMARK 465     ARG A  1303                                                      
REMARK 465     ARG A  1304                                                      
REMARK 465     ASP A  1305                                                      
REMARK 465     PRO A  1306                                                      
REMARK 465     PRO A  1307                                                      
REMARK 465     ARG A  1308                                                      
REMARK 465     GLU A  1309                                                      
REMARK 465     GLY A  1310                                                      
REMARK 465     LEU A  1311                                                      
REMARK 465     TRP A  1312                                                      
REMARK 465     PRO A  1313                                                      
REMARK 465     PRO A  1314                                                      
REMARK 465     PRO A  1315                                                      
REMARK 465     TYR A  1316                                                      
REMARK 465     ARG A  1317                                                      
REMARK 465     PRO A  1318                                                      
REMARK 465     ARG A  1319                                                      
REMARK 465     ARG A  1320                                                      
REMARK 465     ASP A  1321                                                      
REMARK 465     ALA A  1322                                                      
REMARK 465     PHE A  1323                                                      
REMARK 465     GLU A  1324                                                      
REMARK 465     ILE A  1325                                                      
REMARK 465     SER A  1326                                                      
REMARK 465     THR A  1327                                                      
REMARK 465     GLU A  1328                                                      
REMARK 465     GLY A  1329                                                      
REMARK 465     HIS A  1330                                                      
REMARK 465     SER A  1331                                                      
REMARK 465     GLY A  1332                                                      
REMARK 465     PRO A  1333                                                      
REMARK 465     SER A  1334                                                      
REMARK 465     ASN A  1335                                                      
REMARK 465     ARG A  1336                                                      
REMARK 465     ALA A  1337                                                      
REMARK 465     ARG A  1338                                                      
REMARK 465     TRP A  1339                                                      
REMARK 465     GLY A  1340                                                      
REMARK 465     PRO A  1341                                                      
REMARK 465     ARG A  1342                                                      
REMARK 465     GLY A  1343                                                      
REMARK 465     ALA A  1344                                                      
REMARK 465     ARG A  1345                                                      
REMARK 465     SER A  1346                                                      
REMARK 465     HIS A  1347                                                      
REMARK 465     ASN A  1348                                                      
REMARK 465     PRO A  1349                                                      
REMARK 465     ARG A  1350                                                      
REMARK 465     ASN A  1351                                                      
REMARK 465     PRO A  1352                                                      
REMARK 465     ALA A  1353                                                      
REMARK 465     SER A  1354                                                      
REMARK 465     THR A  1355                                                      
REMARK 465     ALA A  1356                                                      
REMARK 465     MET A  1357                                                      
REMARK 465     GLY A  1358                                                      
REMARK 465     SER A  1359                                                      
REMARK 465     SER A  1360                                                      
REMARK 465     VAL A  1361                                                      
REMARK 465     PRO A  1362                                                      
REMARK 465     GLY A  1363                                                      
REMARK 465     TYR A  1364                                                      
REMARK 465     CYS A  1365                                                      
REMARK 465     GLN A  1366                                                      
REMARK 465     PRO A  1367                                                      
REMARK 465     ILE A  1368                                                      
REMARK 465     THR A  1369                                                      
REMARK 465     THR A  1370                                                      
REMARK 465     VAL A  1371                                                      
REMARK 465     THR A  1372                                                      
REMARK 465     ALA A  1373                                                      
REMARK 465     SER A  1374                                                      
REMARK 465     ALA A  1375                                                      
REMARK 465     SER A  1376                                                      
REMARK 465     VAL A  1377                                                      
REMARK 465     THR A  1378                                                      
REMARK 465     VAL A  1379                                                      
REMARK 465     ALA A  1380                                                      
REMARK 465     VAL A  1381                                                      
REMARK 465     HIS A  1382                                                      
REMARK 465     PRO A  1383                                                      
REMARK 465     PRO A  1384                                                      
REMARK 465     PRO A  1385                                                      
REMARK 465     VAL A  1386                                                      
REMARK 465     PRO A  1387                                                      
REMARK 465     GLY A  1388                                                      
REMARK 465     PRO A  1389                                                      
REMARK 465     GLY A  1390                                                      
REMARK 465     ARG A  1391                                                      
REMARK 465     ASN A  1392                                                      
REMARK 465     PRO A  1393                                                      
REMARK 465     ARG A  1394                                                      
REMARK 465     GLY A  1395                                                      
REMARK 465     GLY A  1396                                                      
REMARK 465     LEU A  1397                                                      
REMARK 465     CYS A  1398                                                      
REMARK 465     PRO A  1399                                                      
REMARK 465     GLY A  1400                                                      
REMARK 465     TYR A  1401                                                      
REMARK 465     PRO A  1402                                                      
REMARK 465     GLU A  1403                                                      
REMARK 465     THR A  1404                                                      
REMARK 465     ASP A  1405                                                      
REMARK 465     HIS A  1406                                                      
REMARK 465     GLY A  1407                                                      
REMARK 465     LEU A  1408                                                      
REMARK 465     PHE A  1409                                                      
REMARK 465     GLU A  1410                                                      
REMARK 465     ASP A  1411                                                      
REMARK 465     PRO A  1412                                                      
REMARK 465     HIS A  1413                                                      
REMARK 465     VAL A  1414                                                      
REMARK 465     PRO A  1415                                                      
REMARK 465     PHE A  1416                                                      
REMARK 465     HIS A  1417                                                      
REMARK 465     VAL A  1418                                                      
REMARK 465     ARG A  1419                                                      
REMARK 465     CYS A  1420                                                      
REMARK 465     GLU A  1421                                                      
REMARK 465     ARG A  1422                                                      
REMARK 465     ARG A  1423                                                      
REMARK 465     ASP A  1424                                                      
REMARK 465     SER A  1425                                                      
REMARK 465     LYS A  1426                                                      
REMARK 465     VAL A  1427                                                      
REMARK 465     GLU A  1428                                                      
REMARK 465     VAL A  1429                                                      
REMARK 465     ILE A  1430                                                      
REMARK 465     GLU A  1431                                                      
REMARK 465     LEU A  1432                                                      
REMARK 465     GLN A  1433                                                      
REMARK 465     ASP A  1434                                                      
REMARK 465     VAL A  1435                                                      
REMARK 465     GLU A  1436                                                      
REMARK 465     CYS A  1437                                                      
REMARK 465     GLU A  1438                                                      
REMARK 465     GLU A  1439                                                      
REMARK 465     ARG A  1440                                                      
REMARK 465     PRO A  1441                                                      
REMARK 465     ARG A  1442                                                      
REMARK 465     GLY A  1443                                                      
REMARK 465     SER A  1444                                                      
REMARK 465     SER A  1445                                                      
REMARK 465     SER A  1446                                                      
REMARK 465     ASN A  1447                                                      
REMARK 465     MET B     1                                                      
REMARK 465     ALA B     2                                                      
REMARK 465     SER B     3                                                      
REMARK 465     ALA B     4                                                      
REMARK 465     GLY B     5                                                      
REMARK 465     ASN B     6                                                      
REMARK 465     ALA B     7                                                      
REMARK 465     ALA B     8                                                      
REMARK 465     GLU B     9                                                      
REMARK 465     PRO B    10                                                      
REMARK 465     GLN B    11                                                      
REMARK 465     ASP B    12                                                      
REMARK 465     ARG B    13                                                      
REMARK 465     GLY B    14                                                      
REMARK 465     GLY B    15                                                      
REMARK 465     GLY B    16                                                      
REMARK 465     GLY B    17                                                      
REMARK 465     SER B    18                                                      
REMARK 465     GLY B    19                                                      
REMARK 465     CYS B    20                                                      
REMARK 465     ILE B    21                                                      
REMARK 465     GLY B    22                                                      
REMARK 465     ALA B    23                                                      
REMARK 465     PRO B    24                                                      
REMARK 465     GLY B    25                                                      
REMARK 465     ARG B    26                                                      
REMARK 465     PRO B    27                                                      
REMARK 465     ALA B    28                                                      
REMARK 465     GLY B    29                                                      
REMARK 465     GLY B    30                                                      
REMARK 465     GLY B    31                                                      
REMARK 465     ARG B    32                                                      
REMARK 465     ARG B    33                                                      
REMARK 465     ARG B    34                                                      
REMARK 465     ARG B    35                                                      
REMARK 465     THR B    36                                                      
REMARK 465     GLY B    37                                                      
REMARK 465     GLY B    38                                                      
REMARK 465     LEU B    39                                                      
REMARK 465     ARG B    40                                                      
REMARK 465     ARG B    41                                                      
REMARK 465     ALA B    42                                                      
REMARK 465     ALA B    43                                                      
REMARK 465     ALA B    44                                                      
REMARK 465     PRO B    45                                                      
REMARK 465     ASP B    46                                                      
REMARK 465     ARG B    47                                                      
REMARK 465     ASP B    48                                                      
REMARK 465     TYR B    49                                                      
REMARK 465     LEU B    50                                                      
REMARK 465     HIS B    51                                                      
REMARK 465     ARG B    52                                                      
REMARK 465     PRO B    53                                                      
REMARK 465     SER B    54                                                      
REMARK 465     TYR B    55                                                      
REMARK 465     CYS B    56                                                      
REMARK 465     ASP B    57                                                      
REMARK 465     ALA B    58                                                      
REMARK 465     ALA B    59                                                      
REMARK 465     PHE B    60                                                      
REMARK 465     ALA B    61                                                      
REMARK 465     LEU B    62                                                      
REMARK 465     GLU B    63                                                      
REMARK 465     GLN B    64                                                      
REMARK 465     ILE B    65                                                      
REMARK 465     SER B    66                                                      
REMARK 465     LYS B    67                                                      
REMARK 465     GLY B    68                                                      
REMARK 465     LYS B    69                                                      
REMARK 465     ALA B    70                                                      
REMARK 465     THR B    71                                                      
REMARK 465     GLY B    72                                                      
REMARK 465     ARG B    73                                                      
REMARK 465     LYS B    74                                                      
REMARK 465     ALA B    75                                                      
REMARK 465     ARG B   606                                                      
REMARK 465     ARG B   607                                                      
REMARK 465     LEU B   608                                                      
REMARK 465     ASP B   609                                                      
REMARK 465     ILE B   610                                                      
REMARK 465     PHE B   611                                                      
REMARK 465     CYS B   612                                                      
REMARK 465     CYS B   613                                                      
REMARK 465     PHE B   614                                                      
REMARK 465     THR B   615                                                      
REMARK 465     SER B   616                                                      
REMARK 465     PRO B   617                                                      
REMARK 465     CYS B   618                                                      
REMARK 465     VAL B   619                                                      
REMARK 465     SER B   620                                                      
REMARK 465     ARG B   621                                                      
REMARK 465     VAL B   622                                                      
REMARK 465     ILE B   623                                                      
REMARK 465     GLN B   624                                                      
REMARK 465     VAL B   625                                                      
REMARK 465     GLU B   626                                                      
REMARK 465     PRO B   627                                                      
REMARK 465     GLN B   628                                                      
REMARK 465     ALA B   629                                                      
REMARK 465     TYR B   630                                                      
REMARK 465     THR B   631                                                      
REMARK 465     ASP B   632                                                      
REMARK 465     THR B   633                                                      
REMARK 465     HIS B   634                                                      
REMARK 465     ASP B   635                                                      
REMARK 465     ASN B   636                                                      
REMARK 465     THR B   637                                                      
REMARK 465     ARG B   638                                                      
REMARK 465     TYR B   639                                                      
REMARK 465     SER B   640                                                      
REMARK 465     PRO B   641                                                      
REMARK 465     PRO B   642                                                      
REMARK 465     PRO B   643                                                      
REMARK 465     PRO B   644                                                      
REMARK 465     TYR B   645                                                      
REMARK 465     SER B   646                                                      
REMARK 465     SER B   647                                                      
REMARK 465     HIS B   648                                                      
REMARK 465     SER B   649                                                      
REMARK 465     PHE B   650                                                      
REMARK 465     ALA B   651                                                      
REMARK 465     HIS B   652                                                      
REMARK 465     GLU B   653                                                      
REMARK 465     THR B   654                                                      
REMARK 465     GLN B   655                                                      
REMARK 465     ILE B   656                                                      
REMARK 465     THR B   657                                                      
REMARK 465     MET B   658                                                      
REMARK 465     GLN B   659                                                      
REMARK 465     SER B   660                                                      
REMARK 465     THR B   661                                                      
REMARK 465     VAL B   662                                                      
REMARK 465     GLN B   663                                                      
REMARK 465     LEU B   664                                                      
REMARK 465     ARG B   665                                                      
REMARK 465     THR B   666                                                      
REMARK 465     GLU B   667                                                      
REMARK 465     TYR B   668                                                      
REMARK 465     ASP B   669                                                      
REMARK 465     PRO B   670                                                      
REMARK 465     HIS B   671                                                      
REMARK 465     THR B   672                                                      
REMARK 465     HIS B   673                                                      
REMARK 465     VAL B   674                                                      
REMARK 465     TYR B   675                                                      
REMARK 465     TYR B   676                                                      
REMARK 465     THR B   677                                                      
REMARK 465     THR B   678                                                      
REMARK 465     ALA B   679                                                      
REMARK 465     GLU B   680                                                      
REMARK 465     PRO B   681                                                      
REMARK 465     ARG B   682                                                      
REMARK 465     SER B   683                                                      
REMARK 465     GLU B   684                                                      
REMARK 465     ILE B   685                                                      
REMARK 465     SER B   686                                                      
REMARK 465     VAL B   687                                                      
REMARK 465     GLN B   688                                                      
REMARK 465     PRO B   689                                                      
REMARK 465     VAL B   690                                                      
REMARK 465     THR B   691                                                      
REMARK 465     VAL B   692                                                      
REMARK 465     THR B   693                                                      
REMARK 465     GLN B   694                                                      
REMARK 465     ASP B   695                                                      
REMARK 465     THR B   696                                                      
REMARK 465     LEU B   697                                                      
REMARK 465     SER B   698                                                      
REMARK 465     CYS B   699                                                      
REMARK 465     GLN B   700                                                      
REMARK 465     SER B   701                                                      
REMARK 465     PRO B   702                                                      
REMARK 465     GLU B   703                                                      
REMARK 465     SER B   704                                                      
REMARK 465     THR B   705                                                      
REMARK 465     SER B   706                                                      
REMARK 465     SER B   707                                                      
REMARK 465     THR B   708                                                      
REMARK 465     ARG B   709                                                      
REMARK 465     ASP B   710                                                      
REMARK 465     LEU B   711                                                      
REMARK 465     LEU B   712                                                      
REMARK 465     SER B   713                                                      
REMARK 465     GLN B   714                                                      
REMARK 465     PHE B   715                                                      
REMARK 465     SER B   716                                                      
REMARK 465     ASP B   717                                                      
REMARK 465     SER B   718                                                      
REMARK 465     SER B   719                                                      
REMARK 465     LEU B   720                                                      
REMARK 465     HIS B   721                                                      
REMARK 465     CYS B   722                                                      
REMARK 465     LEU B   723                                                      
REMARK 465     GLU B   724                                                      
REMARK 465     PRO B   725                                                      
REMARK 465     PRO B   726                                                      
REMARK 465     CYS B   727                                                      
REMARK 465     THR B   728                                                      
REMARK 465     LYS B   729                                                      
REMARK 465     TRP B   730                                                      
REMARK 465     THR B   731                                                      
REMARK 465     LEU B   732                                                      
REMARK 465     TYR B  1181                                                      
REMARK 465     PRO B  1182                                                      
REMARK 465     GLU B  1183                                                      
REMARK 465     VAL B  1184                                                      
REMARK 465     SER B  1185                                                      
REMARK 465     PRO B  1186                                                      
REMARK 465     ALA B  1187                                                      
REMARK 465     ASN B  1188                                                      
REMARK 465     GLY B  1189                                                      
REMARK 465     LEU B  1190                                                      
REMARK 465     ASN B  1191                                                      
REMARK 465     ARG B  1192                                                      
REMARK 465     LEU B  1193                                                      
REMARK 465     PRO B  1194                                                      
REMARK 465     THR B  1195                                                      
REMARK 465     PRO B  1196                                                      
REMARK 465     SER B  1197                                                      
REMARK 465     PRO B  1198                                                      
REMARK 465     GLU B  1199                                                      
REMARK 465     PRO B  1200                                                      
REMARK 465     PRO B  1201                                                      
REMARK 465     PRO B  1202                                                      
REMARK 465     SER B  1203                                                      
REMARK 465     VAL B  1204                                                      
REMARK 465     VAL B  1205                                                      
REMARK 465     ARG B  1206                                                      
REMARK 465     PHE B  1207                                                      
REMARK 465     ALA B  1208                                                      
REMARK 465     MET B  1209                                                      
REMARK 465     PRO B  1210                                                      
REMARK 465     PRO B  1211                                                      
REMARK 465     GLY B  1212                                                      
REMARK 465     HIS B  1213                                                      
REMARK 465     THR B  1214                                                      
REMARK 465     HIS B  1215                                                      
REMARK 465     SER B  1216                                                      
REMARK 465     GLY B  1217                                                      
REMARK 465     SER B  1218                                                      
REMARK 465     ASP B  1219                                                      
REMARK 465     SER B  1220                                                      
REMARK 465     SER B  1221                                                      
REMARK 465     ASP B  1222                                                      
REMARK 465     SER B  1223                                                      
REMARK 465     GLU B  1224                                                      
REMARK 465     TYR B  1225                                                      
REMARK 465     SER B  1226                                                      
REMARK 465     SER B  1227                                                      
REMARK 465     GLN B  1228                                                      
REMARK 465     THR B  1229                                                      
REMARK 465     THR B  1230                                                      
REMARK 465     VAL B  1231                                                      
REMARK 465     SER B  1232                                                      
REMARK 465     GLY B  1233                                                      
REMARK 465     LEU B  1234                                                      
REMARK 465     SER B  1235                                                      
REMARK 465     GLU B  1236                                                      
REMARK 465     GLU B  1237                                                      
REMARK 465     LEU B  1238                                                      
REMARK 465     ARG B  1239                                                      
REMARK 465     HIS B  1240                                                      
REMARK 465     TYR B  1241                                                      
REMARK 465     GLU B  1242                                                      
REMARK 465     ALA B  1243                                                      
REMARK 465     GLN B  1244                                                      
REMARK 465     GLN B  1245                                                      
REMARK 465     GLY B  1246                                                      
REMARK 465     ALA B  1247                                                      
REMARK 465     GLY B  1248                                                      
REMARK 465     GLY B  1249                                                      
REMARK 465     PRO B  1250                                                      
REMARK 465     ALA B  1251                                                      
REMARK 465     HIS B  1252                                                      
REMARK 465     GLN B  1253                                                      
REMARK 465     VAL B  1254                                                      
REMARK 465     ILE B  1255                                                      
REMARK 465     VAL B  1256                                                      
REMARK 465     GLU B  1257                                                      
REMARK 465     ALA B  1258                                                      
REMARK 465     THR B  1259                                                      
REMARK 465     GLU B  1260                                                      
REMARK 465     ASN B  1261                                                      
REMARK 465     PRO B  1262                                                      
REMARK 465     VAL B  1263                                                      
REMARK 465     PHE B  1264                                                      
REMARK 465     ALA B  1265                                                      
REMARK 465     HIS B  1266                                                      
REMARK 465     SER B  1267                                                      
REMARK 465     THR B  1268                                                      
REMARK 465     VAL B  1269                                                      
REMARK 465     VAL B  1270                                                      
REMARK 465     HIS B  1271                                                      
REMARK 465     PRO B  1272                                                      
REMARK 465     GLU B  1273                                                      
REMARK 465     SER B  1274                                                      
REMARK 465     ARG B  1275                                                      
REMARK 465     HIS B  1276                                                      
REMARK 465     HIS B  1277                                                      
REMARK 465     PRO B  1278                                                      
REMARK 465     PRO B  1279                                                      
REMARK 465     SER B  1280                                                      
REMARK 465     ASN B  1281                                                      
REMARK 465     PRO B  1282                                                      
REMARK 465     ARG B  1283                                                      
REMARK 465     GLN B  1284                                                      
REMARK 465     GLN B  1285                                                      
REMARK 465     PRO B  1286                                                      
REMARK 465     HIS B  1287                                                      
REMARK 465     LEU B  1288                                                      
REMARK 465     ASP B  1289                                                      
REMARK 465     SER B  1290                                                      
REMARK 465     GLY B  1291                                                      
REMARK 465     SER B  1292                                                      
REMARK 465     LEU B  1293                                                      
REMARK 465     PRO B  1294                                                      
REMARK 465     PRO B  1295                                                      
REMARK 465     GLY B  1296                                                      
REMARK 465     ARG B  1297                                                      
REMARK 465     GLN B  1298                                                      
REMARK 465     GLY B  1299                                                      
REMARK 465     GLN B  1300                                                      
REMARK 465     GLN B  1301                                                      
REMARK 465     PRO B  1302                                                      
REMARK 465     ARG B  1303                                                      
REMARK 465     ARG B  1304                                                      
REMARK 465     ASP B  1305                                                      
REMARK 465     PRO B  1306                                                      
REMARK 465     PRO B  1307                                                      
REMARK 465     ARG B  1308                                                      
REMARK 465     GLU B  1309                                                      
REMARK 465     GLY B  1310                                                      
REMARK 465     LEU B  1311                                                      
REMARK 465     TRP B  1312                                                      
REMARK 465     PRO B  1313                                                      
REMARK 465     PRO B  1314                                                      
REMARK 465     PRO B  1315                                                      
REMARK 465     TYR B  1316                                                      
REMARK 465     ARG B  1317                                                      
REMARK 465     PRO B  1318                                                      
REMARK 465     ARG B  1319                                                      
REMARK 465     ARG B  1320                                                      
REMARK 465     ASP B  1321                                                      
REMARK 465     ALA B  1322                                                      
REMARK 465     PHE B  1323                                                      
REMARK 465     GLU B  1324                                                      
REMARK 465     ILE B  1325                                                      
REMARK 465     SER B  1326                                                      
REMARK 465     THR B  1327                                                      
REMARK 465     GLU B  1328                                                      
REMARK 465     GLY B  1329                                                      
REMARK 465     HIS B  1330                                                      
REMARK 465     SER B  1331                                                      
REMARK 465     GLY B  1332                                                      
REMARK 465     PRO B  1333                                                      
REMARK 465     SER B  1334                                                      
REMARK 465     ASN B  1335                                                      
REMARK 465     ARG B  1336                                                      
REMARK 465     ALA B  1337                                                      
REMARK 465     ARG B  1338                                                      
REMARK 465     TRP B  1339                                                      
REMARK 465     GLY B  1340                                                      
REMARK 465     PRO B  1341                                                      
REMARK 465     ARG B  1342                                                      
REMARK 465     GLY B  1343                                                      
REMARK 465     ALA B  1344                                                      
REMARK 465     ARG B  1345                                                      
REMARK 465     SER B  1346                                                      
REMARK 465     HIS B  1347                                                      
REMARK 465     ASN B  1348                                                      
REMARK 465     PRO B  1349                                                      
REMARK 465     ARG B  1350                                                      
REMARK 465     ASN B  1351                                                      
REMARK 465     PRO B  1352                                                      
REMARK 465     ALA B  1353                                                      
REMARK 465     SER B  1354                                                      
REMARK 465     THR B  1355                                                      
REMARK 465     ALA B  1356                                                      
REMARK 465     MET B  1357                                                      
REMARK 465     GLY B  1358                                                      
REMARK 465     SER B  1359                                                      
REMARK 465     SER B  1360                                                      
REMARK 465     VAL B  1361                                                      
REMARK 465     PRO B  1362                                                      
REMARK 465     GLY B  1363                                                      
REMARK 465     TYR B  1364                                                      
REMARK 465     CYS B  1365                                                      
REMARK 465     GLN B  1366                                                      
REMARK 465     PRO B  1367                                                      
REMARK 465     ILE B  1368                                                      
REMARK 465     THR B  1369                                                      
REMARK 465     THR B  1370                                                      
REMARK 465     VAL B  1371                                                      
REMARK 465     THR B  1372                                                      
REMARK 465     ALA B  1373                                                      
REMARK 465     SER B  1374                                                      
REMARK 465     ALA B  1375                                                      
REMARK 465     SER B  1376                                                      
REMARK 465     VAL B  1377                                                      
REMARK 465     THR B  1378                                                      
REMARK 465     VAL B  1379                                                      
REMARK 465     ALA B  1380                                                      
REMARK 465     VAL B  1381                                                      
REMARK 465     HIS B  1382                                                      
REMARK 465     PRO B  1383                                                      
REMARK 465     PRO B  1384                                                      
REMARK 465     PRO B  1385                                                      
REMARK 465     VAL B  1386                                                      
REMARK 465     PRO B  1387                                                      
REMARK 465     GLY B  1388                                                      
REMARK 465     PRO B  1389                                                      
REMARK 465     GLY B  1390                                                      
REMARK 465     ARG B  1391                                                      
REMARK 465     ASN B  1392                                                      
REMARK 465     PRO B  1393                                                      
REMARK 465     ARG B  1394                                                      
REMARK 465     GLY B  1395                                                      
REMARK 465     GLY B  1396                                                      
REMARK 465     LEU B  1397                                                      
REMARK 465     CYS B  1398                                                      
REMARK 465     PRO B  1399                                                      
REMARK 465     GLY B  1400                                                      
REMARK 465     TYR B  1401                                                      
REMARK 465     PRO B  1402                                                      
REMARK 465     GLU B  1403                                                      
REMARK 465     THR B  1404                                                      
REMARK 465     ASP B  1405                                                      
REMARK 465     HIS B  1406                                                      
REMARK 465     GLY B  1407                                                      
REMARK 465     LEU B  1408                                                      
REMARK 465     PHE B  1409                                                      
REMARK 465     GLU B  1410                                                      
REMARK 465     ASP B  1411                                                      
REMARK 465     PRO B  1412                                                      
REMARK 465     HIS B  1413                                                      
REMARK 465     VAL B  1414                                                      
REMARK 465     PRO B  1415                                                      
REMARK 465     PHE B  1416                                                      
REMARK 465     HIS B  1417                                                      
REMARK 465     VAL B  1418                                                      
REMARK 465     ARG B  1419                                                      
REMARK 465     CYS B  1420                                                      
REMARK 465     GLU B  1421                                                      
REMARK 465     ARG B  1422                                                      
REMARK 465     ARG B  1423                                                      
REMARK 465     ASP B  1424                                                      
REMARK 465     SER B  1425                                                      
REMARK 465     LYS B  1426                                                      
REMARK 465     VAL B  1427                                                      
REMARK 465     GLU B  1428                                                      
REMARK 465     VAL B  1429                                                      
REMARK 465     ILE B  1430                                                      
REMARK 465     GLU B  1431                                                      
REMARK 465     LEU B  1432                                                      
REMARK 465     GLN B  1433                                                      
REMARK 465     ASP B  1434                                                      
REMARK 465     VAL B  1435                                                      
REMARK 465     GLU B  1436                                                      
REMARK 465     CYS B  1437                                                      
REMARK 465     GLU B  1438                                                      
REMARK 465     GLU B  1439                                                      
REMARK 465     ARG B  1440                                                      
REMARK 465     PRO B  1441                                                      
REMARK 465     ARG B  1442                                                      
REMARK 465     GLY B  1443                                                      
REMARK 465     SER B  1444                                                      
REMARK 465     SER B  1445                                                      
REMARK 465     SER B  1446                                                      
REMARK 465     ASN B  1447                                                      
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   N    CYS C    24     O2   PLM C   201              2.18            
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS                                      
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,2(A3,1X,A1,I4,A1,1X,A4,3X),1X,F6.3)               
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   RES CSSEQI ATM2   DEVIATION                     
REMARK 500    CYS B 203   CB    CYS B 203   SG     -0.108                       
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    ASN A  97       52.84    -92.27                                   
REMARK 500    GLU A 150        1.48    -69.40                                   
REMARK 500    LEU A 170       21.08   -142.29                                   
REMARK 500    SER A 243       34.60    -96.02                                   
REMARK 500    PHE A 376       36.27    -97.01                                   
REMARK 500    SER A 435       56.11   -100.29                                   
REMARK 500    VAL A 502      -51.94   -126.71                                   
REMARK 500    LYS A 838      -55.12   -120.90                                   
REMARK 500    ARG A 906      -36.17     79.59                                   
REMARK 500    LEU A 907      -31.25   -156.27                                   
REMARK 500    MET A 956       75.92     52.38                                   
REMARK 500    ASN B  97       53.90    -95.93                                   
REMARK 500    MET B 152      -48.53     66.43                                   
REMARK 500    LEU B 170       14.89   -144.12                                   
REMARK 500    LYS B 205       71.61     58.19                                   
REMARK 500    GLU B 212       47.83    -92.28                                   
REMARK 500    CYS B 226       76.56     59.84                                   
REMARK 500    GLU B 286       19.78     57.35                                   
REMARK 500    MET B 319       -1.94     65.48                                   
REMARK 500    MET B 335       49.19    -84.95                                   
REMARK 500    GLU B 534       -3.35     81.05                                   
REMARK 500    ASP B 535       44.88   -141.11                                   
REMARK 500    ASN B 837       16.30     56.46                                   
REMARK 500    LYS B 838      -55.91   -123.09                                   
REMARK 500    LEU B 902      -32.11   -130.79                                   
REMARK 500    ARG B 906      -36.49     83.44                                   
REMARK 500    LEU B 907      -29.73   -150.18                                   
REMARK 500    ASP B 954       96.06    -69.00                                   
REMARK 500    MET B 956       73.32     48.50                                   
REMARK 500    SER B1008      109.91   -160.20                                   
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS                                         
REMARK 500                                                                      
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH          
REMARK 500 CIS AND TRANS CONFORMATION.  CIS BONDS, IF ANY, ARE LISTED           
REMARK 500 ON CISPEP RECORDS.  TRANS IS DEFINED AS 180 +/- 30 AND               
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.                                  
REMARK 500                                 MODEL     OMEGA                      
REMARK 500 ARG A  906     LEU A  907                  148.89                    
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 620                                                                      
REMARK 620 METAL COORDINATION                                                   
REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE):                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              CA C 205  CA                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 GLU C  89   OE1                                                    
REMARK 620 2 GLU C  89   OE2  58.5                                              
REMARK 620 3 GLU C  90   OE1  79.3  78.3                                        
REMARK 620 4 GLU C  90   OE2 108.9  66.9  46.8                                  
REMARK 620 5 ASP C  95   OD1 143.7 157.5  99.7  95.1                            
REMARK 620 6 ASP C  95   OD2  85.4 142.9  87.8 125.0  58.4                      
REMARK 620 7 THR C 125   O    84.5  99.9 162.0 148.9  88.7  83.0                
REMARK 620 8 GLU C 126   OE2 121.2  67.9 112.9  66.6  93.0 148.0  82.3          
REMARK 620 N                    1     2     3     4     5     6     7           
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              CA C 204  CA                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 GLU C  90   OE2                                                    
REMARK 620 2 GLU C 126   OE1 118.3                                              
REMARK 620 3 GLU C 126   OE2  68.9  49.6                                        
REMARK 620 4 ASP C 129   OD1 144.1  95.3 144.3                                  
REMARK 620 5 ASP C 131   OD2  75.4 140.9 130.9  70.1                            
REMARK 620 N                    1     2     3     4                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              ZN C 203  ZN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 HIS C 140   NE2                                                    
REMARK 620 2 ASP C 147   OD1  91.8                                              
REMARK 620 3 ASP C 147   OD2  83.0  64.2                                        
REMARK 620 4 GLU C 176   OE1 170.1  98.0 101.3                                  
REMARK 620 5 HIS C 182   ND1  81.0  83.6 143.4 100.0                            
REMARK 620 N                    1     2     3     4                             
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: EMD-8955   RELATED DB: EMDB                              
REMARK 900 RELATED ID: 6E1H   RELATED DB: PDB                                   
REMARK 900 6E1H WAS THE STARTING MODEL FOR THE EXTENDED MODEL OF THE 1:2 SHH:   
REMARK 900 PTCH1 COMPLEX DEPOSITED HERE                                         
REMARK 900 RELATED ID: 6RTW   RELATED DB: PDB                                   
REMARK 900 6RTW WAS USED TO OBTAIN THE EXTENDED MODEL OF THE 1:2 SHH:PTCH1      
REMARK 900 COMPLEX                                                              
REMARK 900 RELATED ID: 6RVC   RELATED DB: PDB                                   
REMARK 900 6RTW WAS USED TO OBTAIN THE EXTENDED MODEL OF THE 1:2 SHH:PTCH1      
REMARK 900 COMPLEX                                                              
DBREF  6RVD A    1  1447  UNP    Q13635   PTC1_HUMAN       1   1447             
DBREF  6RVD B    1  1447  UNP    Q13635   PTC1_HUMAN       1   1447             
DBREF  6RVD C   24   197  UNP    Q15465   SHH_HUMAN       24    197             
SEQRES   1 A 1447  MET ALA SER ALA GLY ASN ALA ALA GLU PRO GLN ASP ARG          
SEQRES   2 A 1447  GLY GLY GLY GLY SER GLY CYS ILE GLY ALA PRO GLY ARG          
SEQRES   3 A 1447  PRO ALA GLY GLY GLY ARG ARG ARG ARG THR GLY GLY LEU          
SEQRES   4 A 1447  ARG ARG ALA ALA ALA PRO ASP ARG ASP TYR LEU HIS ARG          
SEQRES   5 A 1447  PRO SER TYR CYS ASP ALA ALA PHE ALA LEU GLU GLN ILE          
SEQRES   6 A 1447  SER LYS GLY LYS ALA THR GLY ARG LYS ALA PRO LEU TRP          
SEQRES   7 A 1447  LEU ARG ALA LYS PHE GLN ARG LEU LEU PHE LYS LEU GLY          
SEQRES   8 A 1447  CYS TYR ILE GLN LYS ASN CYS GLY LYS PHE LEU VAL VAL          
SEQRES   9 A 1447  GLY LEU LEU ILE PHE GLY ALA PHE ALA VAL GLY LEU LYS          
SEQRES  10 A 1447  ALA ALA ASN LEU GLU THR ASN VAL GLU GLU LEU TRP VAL          
SEQRES  11 A 1447  GLU VAL GLY GLY ARG VAL SER ARG GLU LEU ASN TYR THR          
SEQRES  12 A 1447  ARG GLN LYS ILE GLY GLU GLU ALA MET PHE ASN PRO GLN          
SEQRES  13 A 1447  LEU MET ILE GLN THR PRO LYS GLU GLU GLY ALA ASN VAL          
SEQRES  14 A 1447  LEU THR THR GLU ALA LEU LEU GLN HIS LEU ASP SER ALA          
SEQRES  15 A 1447  LEU GLN ALA SER ARG VAL HIS VAL TYR MET TYR ASN ARG          
SEQRES  16 A 1447  GLN TRP LYS LEU GLU HIS LEU CYS TYR LYS SER GLY GLU          
SEQRES  17 A 1447  LEU ILE THR GLU THR GLY TYR MET ASP GLN ILE ILE GLU          
SEQRES  18 A 1447  TYR LEU TYR PRO CYS LEU ILE ILE THR PRO LEU ASP CYS          
SEQRES  19 A 1447  PHE TRP GLU GLY ALA LYS LEU GLN SER GLY THR ALA TYR          
SEQRES  20 A 1447  LEU LEU GLY LYS PRO PRO LEU ARG TRP THR ASN PHE ASP          
SEQRES  21 A 1447  PRO LEU GLU PHE LEU GLU GLU LEU LYS LYS ILE ASN TYR          
SEQRES  22 A 1447  GLN VAL ASP SER TRP GLU GLU MET LEU ASN LYS ALA GLU          
SEQRES  23 A 1447  VAL GLY HIS GLY TYR MET ASP ARG PRO CYS LEU ASN PRO          
SEQRES  24 A 1447  ALA ASP PRO ASP CYS PRO ALA THR ALA PRO ASN LYS ASN          
SEQRES  25 A 1447  SER THR LYS PRO LEU ASP MET ALA LEU VAL LEU ASN GLY          
SEQRES  26 A 1447  GLY CYS HIS GLY LEU SER ARG LYS TYR MET HIS TRP GLN          
SEQRES  27 A 1447  GLU GLU LEU ILE VAL GLY GLY THR VAL LYS ASN SER THR          
SEQRES  28 A 1447  GLY LYS LEU VAL SER ALA HIS ALA LEU GLN THR MET PHE          
SEQRES  29 A 1447  GLN LEU MET THR PRO LYS GLN MET TYR GLU HIS PHE LYS          
SEQRES  30 A 1447  GLY TYR GLU TYR VAL SER HIS ILE ASN TRP ASN GLU ASP          
SEQRES  31 A 1447  LYS ALA ALA ALA ILE LEU GLU ALA TRP GLN ARG THR TYR          
SEQRES  32 A 1447  VAL GLU VAL VAL HIS GLN SER VAL ALA GLN ASN SER THR          
SEQRES  33 A 1447  GLN LYS VAL LEU SER PHE THR THR THR THR LEU ASP ASP          
SEQRES  34 A 1447  ILE LEU LYS SER PHE SER ASP VAL SER VAL ILE ARG VAL          
SEQRES  35 A 1447  ALA SER GLY TYR LEU LEU MET LEU ALA TYR ALA CYS LEU          
SEQRES  36 A 1447  THR MET LEU ARG TRP ASP CYS SER LYS SER GLN GLY ALA          
SEQRES  37 A 1447  VAL GLY LEU ALA GLY VAL LEU LEU VAL ALA LEU SER VAL          
SEQRES  38 A 1447  ALA ALA GLY LEU GLY LEU CYS SER LEU ILE GLY ILE SER          
SEQRES  39 A 1447  PHE ASN ALA ALA THR THR GLN VAL LEU PRO PHE LEU ALA          
SEQRES  40 A 1447  LEU GLY VAL GLY VAL ASP ASP VAL PHE LEU LEU ALA HIS          
SEQRES  41 A 1447  ALA PHE SER GLU THR GLY GLN ASN LYS ARG ILE PRO PHE          
SEQRES  42 A 1447  GLU ASP ARG THR GLY GLU CYS LEU LYS ARG THR GLY ALA          
SEQRES  43 A 1447  SER VAL ALA LEU THR SER ILE SER ASN VAL THR ALA PHE          
SEQRES  44 A 1447  PHE MET ALA ALA LEU ILE PRO ILE PRO ALA LEU ARG ALA          
SEQRES  45 A 1447  PHE SER LEU GLN ALA ALA VAL VAL VAL VAL PHE ASN PHE          
SEQRES  46 A 1447  ALA MET VAL LEU LEU ILE PHE PRO ALA ILE LEU SER MET          
SEQRES  47 A 1447  ASP LEU TYR ARG ARG GLU ASP ARG ARG LEU ASP ILE PHE          
SEQRES  48 A 1447  CYS CYS PHE THR SER PRO CYS VAL SER ARG VAL ILE GLN          
SEQRES  49 A 1447  VAL GLU PRO GLN ALA TYR THR ASP THR HIS ASP ASN THR          
SEQRES  50 A 1447  ARG TYR SER PRO PRO PRO PRO TYR SER SER HIS SER PHE          
SEQRES  51 A 1447  ALA HIS GLU THR GLN ILE THR MET GLN SER THR VAL GLN          
SEQRES  52 A 1447  LEU ARG THR GLU TYR ASP PRO HIS THR HIS VAL TYR TYR          
SEQRES  53 A 1447  THR THR ALA GLU PRO ARG SER GLU ILE SER VAL GLN PRO          
SEQRES  54 A 1447  VAL THR VAL THR GLN ASP THR LEU SER CYS GLN SER PRO          
SEQRES  55 A 1447  GLU SER THR SER SER THR ARG ASP LEU LEU SER GLN PHE          
SEQRES  56 A 1447  SER ASP SER SER LEU HIS CYS LEU GLU PRO PRO CYS THR          
SEQRES  57 A 1447  LYS TRP THR LEU SER SER PHE ALA GLU LYS HIS TYR ALA          
SEQRES  58 A 1447  PRO PHE LEU LEU LYS PRO LYS ALA LYS VAL VAL VAL ILE          
SEQRES  59 A 1447  PHE LEU PHE LEU GLY LEU LEU GLY VAL SER LEU TYR GLY          
SEQRES  60 A 1447  THR THR ARG VAL ARG ASP GLY LEU ASP LEU THR ASP ILE          
SEQRES  61 A 1447  VAL PRO ARG GLU THR ARG GLU TYR ASP PHE ILE ALA ALA          
SEQRES  62 A 1447  GLN PHE LYS TYR PHE SER PHE TYR ASN MET TYR ILE VAL          
SEQRES  63 A 1447  THR GLN LYS ALA ASP TYR PRO ASN ILE GLN HIS LEU LEU          
SEQRES  64 A 1447  TYR ASP LEU HIS ARG SER PHE SER ASN VAL LYS TYR VAL          
SEQRES  65 A 1447  MET LEU GLU GLU ASN LYS GLN LEU PRO LYS MET TRP LEU          
SEQRES  66 A 1447  HIS TYR PHE ARG ASP TRP LEU GLN GLY LEU GLN ASP ALA          
SEQRES  67 A 1447  PHE ASP SER ASP TRP GLU THR GLY LYS ILE MET PRO ASN          
SEQRES  68 A 1447  ASN TYR LYS ASN GLY SER ASP ASP GLY VAL LEU ALA TYR          
SEQRES  69 A 1447  LYS LEU LEU VAL GLN THR GLY SER ARG ASP LYS PRO ILE          
SEQRES  70 A 1447  ASP ILE SER GLN LEU THR LYS GLN ARG LEU VAL ASP ALA          
SEQRES  71 A 1447  ASP GLY ILE ILE ASN PRO SER ALA PHE TYR ILE TYR LEU          
SEQRES  72 A 1447  THR ALA TRP VAL SER ASN ASP PRO VAL ALA TYR ALA ALA          
SEQRES  73 A 1447  SER GLN ALA ASN ILE ARG PRO HIS ARG PRO GLU TRP VAL          
SEQRES  74 A 1447  HIS ASP LYS ALA ASP TYR MET PRO GLU THR ARG LEU ARG          
SEQRES  75 A 1447  ILE PRO ALA ALA GLU PRO ILE GLU TYR ALA GLN PHE PRO          
SEQRES  76 A 1447  PHE TYR LEU ASN GLY LEU ARG ASP THR SER ASP PHE VAL          
SEQRES  77 A 1447  GLU ALA ILE GLU LYS VAL ARG THR ILE CYS SER ASN TYR          
SEQRES  78 A 1447  THR SER LEU GLY LEU SER SER TYR PRO ASN GLY TYR PRO          
SEQRES  79 A 1447  PHE LEU PHE TRP GLU GLN TYR ILE GLY LEU ARG HIS TRP          
SEQRES  80 A 1447  LEU LEU LEU PHE ILE SER VAL VAL LEU ALA CYS THR PHE          
SEQRES  81 A 1447  LEU VAL CYS ALA VAL PHE LEU LEU ASN PRO TRP THR ALA          
SEQRES  82 A 1447  GLY ILE ILE VAL MET VAL LEU ALA LEU MET THR VAL GLU          
SEQRES  83 A 1447  LEU PHE GLY MET MET GLY LEU ILE GLY ILE LYS LEU SER          
SEQRES  84 A 1447  ALA VAL PRO VAL VAL ILE LEU ILE ALA SER VAL GLY ILE          
SEQRES  85 A 1447  GLY VAL GLU PHE THR VAL HIS VAL ALA LEU ALA PHE LEU          
SEQRES  86 A 1447  THR ALA ILE GLY ASP LYS ASN ARG ARG ALA VAL LEU ALA          
SEQRES  87 A 1447  LEU GLU HIS MET PHE ALA PRO VAL LEU ASP GLY ALA VAL          
SEQRES  88 A 1447  SER THR LEU LEU GLY VAL LEU MET LEU ALA GLY SER GLU          
SEQRES  89 A 1447  PHE ASP PHE ILE VAL ARG TYR PHE PHE ALA VAL LEU ALA          
SEQRES  90 A 1447  ILE LEU THR ILE LEU GLY VAL LEU ASN GLY LEU VAL LEU          
SEQRES  91 A 1447  LEU PRO VAL LEU LEU SER PHE PHE GLY PRO TYR PRO GLU          
SEQRES  92 A 1447  VAL SER PRO ALA ASN GLY LEU ASN ARG LEU PRO THR PRO          
SEQRES  93 A 1447  SER PRO GLU PRO PRO PRO SER VAL VAL ARG PHE ALA MET          
SEQRES  94 A 1447  PRO PRO GLY HIS THR HIS SER GLY SER ASP SER SER ASP          
SEQRES  95 A 1447  SER GLU TYR SER SER GLN THR THR VAL SER GLY LEU SER          
SEQRES  96 A 1447  GLU GLU LEU ARG HIS TYR GLU ALA GLN GLN GLY ALA GLY          
SEQRES  97 A 1447  GLY PRO ALA HIS GLN VAL ILE VAL GLU ALA THR GLU ASN          
SEQRES  98 A 1447  PRO VAL PHE ALA HIS SER THR VAL VAL HIS PRO GLU SER          
SEQRES  99 A 1447  ARG HIS HIS PRO PRO SER ASN PRO ARG GLN GLN PRO HIS          
SEQRES 100 A 1447  LEU ASP SER GLY SER LEU PRO PRO GLY ARG GLN GLY GLN          
SEQRES 101 A 1447  GLN PRO ARG ARG ASP PRO PRO ARG GLU GLY LEU TRP PRO          
SEQRES 102 A 1447  PRO PRO TYR ARG PRO ARG ARG ASP ALA PHE GLU ILE SER          
SEQRES 103 A 1447  THR GLU GLY HIS SER GLY PRO SER ASN ARG ALA ARG TRP          
SEQRES 104 A 1447  GLY PRO ARG GLY ALA ARG SER HIS ASN PRO ARG ASN PRO          
SEQRES 105 A 1447  ALA SER THR ALA MET GLY SER SER VAL PRO GLY TYR CYS          
SEQRES 106 A 1447  GLN PRO ILE THR THR VAL THR ALA SER ALA SER VAL THR          
SEQRES 107 A 1447  VAL ALA VAL HIS PRO PRO PRO VAL PRO GLY PRO GLY ARG          
SEQRES 108 A 1447  ASN PRO ARG GLY GLY LEU CYS PRO GLY TYR PRO GLU THR          
SEQRES 109 A 1447  ASP HIS GLY LEU PHE GLU ASP PRO HIS VAL PRO PHE HIS          
SEQRES 110 A 1447  VAL ARG CYS GLU ARG ARG ASP SER LYS VAL GLU VAL ILE          
SEQRES 111 A 1447  GLU LEU GLN ASP VAL GLU CYS GLU GLU ARG PRO ARG GLY          
SEQRES 112 A 1447  SER SER SER ASN                                              
SEQRES   1 B 1447  MET ALA SER ALA GLY ASN ALA ALA GLU PRO GLN ASP ARG          
SEQRES   2 B 1447  GLY GLY GLY GLY SER GLY CYS ILE GLY ALA PRO GLY ARG          
SEQRES   3 B 1447  PRO ALA GLY GLY GLY ARG ARG ARG ARG THR GLY GLY LEU          
SEQRES   4 B 1447  ARG ARG ALA ALA ALA PRO ASP ARG ASP TYR LEU HIS ARG          
SEQRES   5 B 1447  PRO SER TYR CYS ASP ALA ALA PHE ALA LEU GLU GLN ILE          
SEQRES   6 B 1447  SER LYS GLY LYS ALA THR GLY ARG LYS ALA PRO LEU TRP          
SEQRES   7 B 1447  LEU ARG ALA LYS PHE GLN ARG LEU LEU PHE LYS LEU GLY          
SEQRES   8 B 1447  CYS TYR ILE GLN LYS ASN CYS GLY LYS PHE LEU VAL VAL          
SEQRES   9 B 1447  GLY LEU LEU ILE PHE GLY ALA PHE ALA VAL GLY LEU LYS          
SEQRES  10 B 1447  ALA ALA ASN LEU GLU THR ASN VAL GLU GLU LEU TRP VAL          
SEQRES  11 B 1447  GLU VAL GLY GLY ARG VAL SER ARG GLU LEU ASN TYR THR          
SEQRES  12 B 1447  ARG GLN LYS ILE GLY GLU GLU ALA MET PHE ASN PRO GLN          
SEQRES  13 B 1447  LEU MET ILE GLN THR PRO LYS GLU GLU GLY ALA ASN VAL          
SEQRES  14 B 1447  LEU THR THR GLU ALA LEU LEU GLN HIS LEU ASP SER ALA          
SEQRES  15 B 1447  LEU GLN ALA SER ARG VAL HIS VAL TYR MET TYR ASN ARG          
SEQRES  16 B 1447  GLN TRP LYS LEU GLU HIS LEU CYS TYR LYS SER GLY GLU          
SEQRES  17 B 1447  LEU ILE THR GLU THR GLY TYR MET ASP GLN ILE ILE GLU          
SEQRES  18 B 1447  TYR LEU TYR PRO CYS LEU ILE ILE THR PRO LEU ASP CYS          
SEQRES  19 B 1447  PHE TRP GLU GLY ALA LYS LEU GLN SER GLY THR ALA TYR          
SEQRES  20 B 1447  LEU LEU GLY LYS PRO PRO LEU ARG TRP THR ASN PHE ASP          
SEQRES  21 B 1447  PRO LEU GLU PHE LEU GLU GLU LEU LYS LYS ILE ASN TYR          
SEQRES  22 B 1447  GLN VAL ASP SER TRP GLU GLU MET LEU ASN LYS ALA GLU          
SEQRES  23 B 1447  VAL GLY HIS GLY TYR MET ASP ARG PRO CYS LEU ASN PRO          
SEQRES  24 B 1447  ALA ASP PRO ASP CYS PRO ALA THR ALA PRO ASN LYS ASN          
SEQRES  25 B 1447  SER THR LYS PRO LEU ASP MET ALA LEU VAL LEU ASN GLY          
SEQRES  26 B 1447  GLY CYS HIS GLY LEU SER ARG LYS TYR MET HIS TRP GLN          
SEQRES  27 B 1447  GLU GLU LEU ILE VAL GLY GLY THR VAL LYS ASN SER THR          
SEQRES  28 B 1447  GLY LYS LEU VAL SER ALA HIS ALA LEU GLN THR MET PHE          
SEQRES  29 B 1447  GLN LEU MET THR PRO LYS GLN MET TYR GLU HIS PHE LYS          
SEQRES  30 B 1447  GLY TYR GLU TYR VAL SER HIS ILE ASN TRP ASN GLU ASP          
SEQRES  31 B 1447  LYS ALA ALA ALA ILE LEU GLU ALA TRP GLN ARG THR TYR          
SEQRES  32 B 1447  VAL GLU VAL VAL HIS GLN SER VAL ALA GLN ASN SER THR          
SEQRES  33 B 1447  GLN LYS VAL LEU SER PHE THR THR THR THR LEU ASP ASP          
SEQRES  34 B 1447  ILE LEU LYS SER PHE SER ASP VAL SER VAL ILE ARG VAL          
SEQRES  35 B 1447  ALA SER GLY TYR LEU LEU MET LEU ALA TYR ALA CYS LEU          
SEQRES  36 B 1447  THR MET LEU ARG TRP ASP CYS SER LYS SER GLN GLY ALA          
SEQRES  37 B 1447  VAL GLY LEU ALA GLY VAL LEU LEU VAL ALA LEU SER VAL          
SEQRES  38 B 1447  ALA ALA GLY LEU GLY LEU CYS SER LEU ILE GLY ILE SER          
SEQRES  39 B 1447  PHE ASN ALA ALA THR THR GLN VAL LEU PRO PHE LEU ALA          
SEQRES  40 B 1447  LEU GLY VAL GLY VAL ASP ASP VAL PHE LEU LEU ALA HIS          
SEQRES  41 B 1447  ALA PHE SER GLU THR GLY GLN ASN LYS ARG ILE PRO PHE          
SEQRES  42 B 1447  GLU ASP ARG THR GLY GLU CYS LEU LYS ARG THR GLY ALA          
SEQRES  43 B 1447  SER VAL ALA LEU THR SER ILE SER ASN VAL THR ALA PHE          
SEQRES  44 B 1447  PHE MET ALA ALA LEU ILE PRO ILE PRO ALA LEU ARG ALA          
SEQRES  45 B 1447  PHE SER LEU GLN ALA ALA VAL VAL VAL VAL PHE ASN PHE          
SEQRES  46 B 1447  ALA MET VAL LEU LEU ILE PHE PRO ALA ILE LEU SER MET          
SEQRES  47 B 1447  ASP LEU TYR ARG ARG GLU ASP ARG ARG LEU ASP ILE PHE          
SEQRES  48 B 1447  CYS CYS PHE THR SER PRO CYS VAL SER ARG VAL ILE GLN          
SEQRES  49 B 1447  VAL GLU PRO GLN ALA TYR THR ASP THR HIS ASP ASN THR          
SEQRES  50 B 1447  ARG TYR SER PRO PRO PRO PRO TYR SER SER HIS SER PHE          
SEQRES  51 B 1447  ALA HIS GLU THR GLN ILE THR MET GLN SER THR VAL GLN          
SEQRES  52 B 1447  LEU ARG THR GLU TYR ASP PRO HIS THR HIS VAL TYR TYR          
SEQRES  53 B 1447  THR THR ALA GLU PRO ARG SER GLU ILE SER VAL GLN PRO          
SEQRES  54 B 1447  VAL THR VAL THR GLN ASP THR LEU SER CYS GLN SER PRO          
SEQRES  55 B 1447  GLU SER THR SER SER THR ARG ASP LEU LEU SER GLN PHE          
SEQRES  56 B 1447  SER ASP SER SER LEU HIS CYS LEU GLU PRO PRO CYS THR          
SEQRES  57 B 1447  LYS TRP THR LEU SER SER PHE ALA GLU LYS HIS TYR ALA          
SEQRES  58 B 1447  PRO PHE LEU LEU LYS PRO LYS ALA LYS VAL VAL VAL ILE          
SEQRES  59 B 1447  PHE LEU PHE LEU GLY LEU LEU GLY VAL SER LEU TYR GLY          
SEQRES  60 B 1447  THR THR ARG VAL ARG ASP GLY LEU ASP LEU THR ASP ILE          
SEQRES  61 B 1447  VAL PRO ARG GLU THR ARG GLU TYR ASP PHE ILE ALA ALA          
SEQRES  62 B 1447  GLN PHE LYS TYR PHE SER PHE TYR ASN MET TYR ILE VAL          
SEQRES  63 B 1447  THR GLN LYS ALA ASP TYR PRO ASN ILE GLN HIS LEU LEU          
SEQRES  64 B 1447  TYR ASP LEU HIS ARG SER PHE SER ASN VAL LYS TYR VAL          
SEQRES  65 B 1447  MET LEU GLU GLU ASN LYS GLN LEU PRO LYS MET TRP LEU          
SEQRES  66 B 1447  HIS TYR PHE ARG ASP TRP LEU GLN GLY LEU GLN ASP ALA          
SEQRES  67 B 1447  PHE ASP SER ASP TRP GLU THR GLY LYS ILE MET PRO ASN          
SEQRES  68 B 1447  ASN TYR LYS ASN GLY SER ASP ASP GLY VAL LEU ALA TYR          
SEQRES  69 B 1447  LYS LEU LEU VAL GLN THR GLY SER ARG ASP LYS PRO ILE          
SEQRES  70 B 1447  ASP ILE SER GLN LEU THR LYS GLN ARG LEU VAL ASP ALA          
SEQRES  71 B 1447  ASP GLY ILE ILE ASN PRO SER ALA PHE TYR ILE TYR LEU          
SEQRES  72 B 1447  THR ALA TRP VAL SER ASN ASP PRO VAL ALA TYR ALA ALA          
SEQRES  73 B 1447  SER GLN ALA ASN ILE ARG PRO HIS ARG PRO GLU TRP VAL          
SEQRES  74 B 1447  HIS ASP LYS ALA ASP TYR MET PRO GLU THR ARG LEU ARG          
SEQRES  75 B 1447  ILE PRO ALA ALA GLU PRO ILE GLU TYR ALA GLN PHE PRO          
SEQRES  76 B 1447  PHE TYR LEU ASN GLY LEU ARG ASP THR SER ASP PHE VAL          
SEQRES  77 B 1447  GLU ALA ILE GLU LYS VAL ARG THR ILE CYS SER ASN TYR          
SEQRES  78 B 1447  THR SER LEU GLY LEU SER SER TYR PRO ASN GLY TYR PRO          
SEQRES  79 B 1447  PHE LEU PHE TRP GLU GLN TYR ILE GLY LEU ARG HIS TRP          
SEQRES  80 B 1447  LEU LEU LEU PHE ILE SER VAL VAL LEU ALA CYS THR PHE          
SEQRES  81 B 1447  LEU VAL CYS ALA VAL PHE LEU LEU ASN PRO TRP THR ALA          
SEQRES  82 B 1447  GLY ILE ILE VAL MET VAL LEU ALA LEU MET THR VAL GLU          
SEQRES  83 B 1447  LEU PHE GLY MET MET GLY LEU ILE GLY ILE LYS LEU SER          
SEQRES  84 B 1447  ALA VAL PRO VAL VAL ILE LEU ILE ALA SER VAL GLY ILE          
SEQRES  85 B 1447  GLY VAL GLU PHE THR VAL HIS VAL ALA LEU ALA PHE LEU          
SEQRES  86 B 1447  THR ALA ILE GLY ASP LYS ASN ARG ARG ALA VAL LEU ALA          
SEQRES  87 B 1447  LEU GLU HIS MET PHE ALA PRO VAL LEU ASP GLY ALA VAL          
SEQRES  88 B 1447  SER THR LEU LEU GLY VAL LEU MET LEU ALA GLY SER GLU          
SEQRES  89 B 1447  PHE ASP PHE ILE VAL ARG TYR PHE PHE ALA VAL LEU ALA          
SEQRES  90 B 1447  ILE LEU THR ILE LEU GLY VAL LEU ASN GLY LEU VAL LEU          
SEQRES  91 B 1447  LEU PRO VAL LEU LEU SER PHE PHE GLY PRO TYR PRO GLU          
SEQRES  92 B 1447  VAL SER PRO ALA ASN GLY LEU ASN ARG LEU PRO THR PRO          
SEQRES  93 B 1447  SER PRO GLU PRO PRO PRO SER VAL VAL ARG PHE ALA MET          
SEQRES  94 B 1447  PRO PRO GLY HIS THR HIS SER GLY SER ASP SER SER ASP          
SEQRES  95 B 1447  SER GLU TYR SER SER GLN THR THR VAL SER GLY LEU SER          
SEQRES  96 B 1447  GLU GLU LEU ARG HIS TYR GLU ALA GLN GLN GLY ALA GLY          
SEQRES  97 B 1447  GLY PRO ALA HIS GLN VAL ILE VAL GLU ALA THR GLU ASN          
SEQRES  98 B 1447  PRO VAL PHE ALA HIS SER THR VAL VAL HIS PRO GLU SER          
SEQRES  99 B 1447  ARG HIS HIS PRO PRO SER ASN PRO ARG GLN GLN PRO HIS          
SEQRES 100 B 1447  LEU ASP SER GLY SER LEU PRO PRO GLY ARG GLN GLY GLN          
SEQRES 101 B 1447  GLN PRO ARG ARG ASP PRO PRO ARG GLU GLY LEU TRP PRO          
SEQRES 102 B 1447  PRO PRO TYR ARG PRO ARG ARG ASP ALA PHE GLU ILE SER          
SEQRES 103 B 1447  THR GLU GLY HIS SER GLY PRO SER ASN ARG ALA ARG TRP          
SEQRES 104 B 1447  GLY PRO ARG GLY ALA ARG SER HIS ASN PRO ARG ASN PRO          
SEQRES 105 B 1447  ALA SER THR ALA MET GLY SER SER VAL PRO GLY TYR CYS          
SEQRES 106 B 1447  GLN PRO ILE THR THR VAL THR ALA SER ALA SER VAL THR          
SEQRES 107 B 1447  VAL ALA VAL HIS PRO PRO PRO VAL PRO GLY PRO GLY ARG          
SEQRES 108 B 1447  ASN PRO ARG GLY GLY LEU CYS PRO GLY TYR PRO GLU THR          
SEQRES 109 B 1447  ASP HIS GLY LEU PHE GLU ASP PRO HIS VAL PRO PHE HIS          
SEQRES 110 B 1447  VAL ARG CYS GLU ARG ARG ASP SER LYS VAL GLU VAL ILE          
SEQRES 111 B 1447  GLU LEU GLN ASP VAL GLU CYS GLU GLU ARG PRO ARG GLY          
SEQRES 112 B 1447  SER SER SER ASN                                              
SEQRES   1 C  174  CYS GLY PRO GLY ARG GLY PHE GLY LYS ARG ARG HIS PRO          
SEQRES   2 C  174  LYS LYS LEU THR PRO LEU ALA TYR LYS GLN PHE ILE PRO          
SEQRES   3 C  174  ASN VAL ALA GLU LYS THR LEU GLY ALA SER GLY ARG TYR          
SEQRES   4 C  174  GLU GLY LYS ILE SER ARG ASN SER GLU ARG PHE LYS GLU          
SEQRES   5 C  174  LEU THR PRO ASN TYR ASN PRO ASP ILE ILE PHE LYS ASP          
SEQRES   6 C  174  GLU GLU ASN THR GLY ALA ASP ARG LEU MET THR GLN ARG          
SEQRES   7 C  174  CYS LYS ASP LYS LEU ASN ALA LEU ALA ILE SER VAL MET          
SEQRES   8 C  174  ASN GLN TRP PRO GLY VAL LYS LEU ARG VAL THR GLU GLY          
SEQRES   9 C  174  TRP ASP GLU ASP GLY HIS HIS SER GLU GLU SER LEU HIS          
SEQRES  10 C  174  TYR GLU GLY ARG ALA VAL ASP ILE THR THR SER ASP ARG          
SEQRES  11 C  174  ASP ARG SER LYS TYR GLY MET LEU ALA ARG LEU ALA VAL          
SEQRES  12 C  174  GLU ALA GLY PHE ASP TRP VAL TYR TYR GLU SER LYS ALA          
SEQRES  13 C  174  HIS ILE HIS CYS SER VAL LYS ALA GLU ASN SER VAL ALA          
SEQRES  14 C  174  ALA LYS SER GLY GLY                                          
HET    NAG  D   1      14                                                       
HET    NAG  D   2      14                                                       
HET    CLR  A1501      28                                                       
HET    NAG  A1502      14                                                       
HET    NAG  A1503      14                                                       
HET    NAG  A1504      14                                                       
HET    NAG  A1505      14                                                       
HET    NAG  A1508      14                                                       
HET    CLR  B1501      28                                                       
HET    CLR  B1502      28                                                       
HET    NAG  B1503      14                                                       
HET    NAG  B1504      14                                                       
HET    PLM  C 201      17                                                       
HET    CLR  C 202      28                                                       
HET     ZN  C 203       1                                                       
HET     CA  C 204       1                                                       
HET     CA  C 205       1                                                       
HETNAM     NAG 2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSE                         
HETNAM     CLR CHOLESTEROL                                                      
HETNAM     PLM PALMITIC ACID                                                    
HETNAM      ZN ZINC ION                                                         
HETNAM      CA CALCIUM ION                                                      
FORMUL   4  NAG    9(C8 H15 N O6)                                               
FORMUL   5  CLR    4(C27 H46 O)                                                 
FORMUL  15  PLM    C16 H32 O2                                                   
FORMUL  17   ZN    ZN 2+                                                        
FORMUL  18   CA    2(CA 2+)                                                     
HELIX    1 AA1 LYS A   74  ASN A   97  1                                  24    
HELIX    2 AA2 GLY A   99  GLY A  115  1                                  17    
HELIX    3 AA3 LEU A  116  ALA A  118  5                                   3    
HELIX    4 AA4 ASN A  124  LEU A  128  5                                   5    
HELIX    5 AA5 GLY A  133  LYS A  146  1                                  14    
HELIX    6 AA6 GLY A  148  GLU A  150  5                                   3    
HELIX    7 AA7 THR A  171  ARG A  187  1                                  17    
HELIX    8 AA8 LYS A  198  LEU A  202  5                                   5    
HELIX    9 AA9 TYR A  215  TYR A  222  1                                   8    
HELIX   10 AB1 PHE A  235  ALA A  239  5                                   5    
HELIX   11 AB2 ASP A  260  ILE A  271  1                                  12    
HELIX   12 AB3 VAL A  275  ALA A  285  1                                  11    
HELIX   13 AB4 ASP A  318  ASN A  324  1                                   7    
HELIX   14 AB5 THR A  368  PHE A  376  1                                   9    
HELIX   15 AB6 ASN A  388  GLN A  409  1                                  22    
HELIX   16 AB7 THR A  423  SER A  435  1                                  13    
HELIX   17 AB8 SER A  438  MET A  457  1                                  20    
HELIX   18 AB9 GLN A  466  ILE A  491  1                                  26    
HELIX   19 AC1 ASN A  496  VAL A  502  1                                   7    
HELIX   20 AC2 VAL A  502  LYS A  529  1                                  28    
HELIX   21 AC3 ARG A  536  ALA A  563  1                                  28    
HELIX   22 AC4 ILE A  567  ILE A  591  1                                  25    
HELIX   23 AC5 ILE A  591  ARG A  606  1                                  16    
HELIX   24 AC6 SER A  733  ALA A  741  1                                   9    
HELIX   25 AC7 LYS A  746  ARG A  770  1                                  25    
HELIX   26 AC8 ASP A  776  VAL A  781  1                                   6    
HELIX   27 AC9 THR A  785  PHE A  798  1                                  14    
HELIX   28 AD1 GLN A  816  SER A  825  1                                  10    
HELIX   29 AD2 MET A  843  GLY A  866  1                                  24    
HELIX   30 AD3 SER A  877  VAL A  888  1                                  12    
HELIX   31 AD4 ILE A  897  LEU A  902  5                                   6    
HELIX   32 AD5 ALA A  918  ASP A  930  1                                  13    
HELIX   33 AD6 ASP A  930  SER A  937  1                                   8    
HELIX   34 AD7 ASP A  983  GLY A 1005  1                                  23    
HELIX   35 AD8 TYR A 1013  TRP A 1018  1                                   6    
HELIX   36 AD9 GLY A 1023  LEU A 1047  1                                  25    
HELIX   37 AE1 ASN A 1049  GLY A 1075  1                                  27    
HELIX   38 AE2 SER A 1079  GLY A 1093  1                                  15    
HELIX   39 AE3 GLY A 1093  THR A 1106  1                                  14    
HELIX   40 AE4 ASP A 1110  PHE A 1123  1                                  14    
HELIX   41 AE5 PHE A 1123  MET A 1139  1                                  17    
HELIX   42 AE6 PHE A 1145  PHE A 1152  1                                   8    
HELIX   43 AE7 PHE A 1152  LEU A 1168  1                                  17    
HELIX   44 AE8 VAL A 1169  PHE A 1178  1                                  10    
HELIX   45 AE9 LEU B   77  ASN B   97  1                                  21    
HELIX   46 AF1 ASN B   97  GLY B  115  1                                  19    
HELIX   47 AF2 LEU B  116  ALA B  118  5                                   3    
HELIX   48 AF3 ASN B  124  TRP B  129  1                                   6    
HELIX   49 AF4 ARG B  135  ILE B  147  1                                  13    
HELIX   50 AF5 THR B  171  ARG B  187  1                                  17    
HELIX   51 AF6 THR B  213  GLU B  221  1                                   9    
HELIX   52 AF7 THR B  230  GLN B  242  5                                  13    
HELIX   53 AF8 ASP B  260  ILE B  271  1                                  12    
HELIX   54 AF9 VAL B  275  ALA B  285  1                                  11    
HELIX   55 AG1 THR B  368  PHE B  376  1                                   9    
HELIX   56 AG2 ASN B  388  GLN B  409  1                                  22    
HELIX   57 AG3 THR B  423  SER B  435  1                                  13    
HELIX   58 AG4 SER B  438  MET B  457  1                                  20    
HELIX   59 AG5 GLN B  466  ILE B  491  1                                  26    
HELIX   60 AG6 ASN B  496  LYS B  529  1                                  34    
HELIX   61 AG7 ARG B  536  MET B  561  1                                  26    
HELIX   62 AG8 ILE B  567  ILE B  591  1                                  25    
HELIX   63 AG9 ILE B  591  ASP B  605  1                                  15    
HELIX   64 AH1 ALA B  736  ALA B  741  1                                   6    
HELIX   65 AH2 PRO B  742  LEU B  744  5                                   3    
HELIX   66 AH3 LYS B  746  ARG B  770  1                                  25    
HELIX   67 AH4 THR B  785  PHE B  798  1                                  14    
HELIX   68 AH5 ILE B  815  PHE B  826  1                                  12    
HELIX   69 AH6 MET B  843  GLY B  866  1                                  24    
HELIX   70 AH7 SER B  877  GLN B  889  1                                  13    
HELIX   71 AH8 ASP B  898  LEU B  902  5                                   5    
HELIX   72 AH9 ALA B  918  ASP B  930  1                                  13    
HELIX   73 AI1 ASP B  930  SER B  937  1                                   8    
HELIX   74 AI2 ASP B  983  GLY B 1005  1                                  23    
HELIX   75 AI3 TYR B 1013  TRP B 1018  1                                   6    
HELIX   76 AI4 GLU B 1019  ILE B 1022  5                                   4    
HELIX   77 AI5 GLY B 1023  LEU B 1048  1                                  26    
HELIX   78 AI6 ASN B 1049  GLY B 1075  1                                  27    
HELIX   79 AI7 SER B 1079  ALA B 1107  1                                  29    
HELIX   80 AI8 ASP B 1110  LEU B 1138  1                                  29    
HELIX   81 AI9 MET B 1139  ALA B 1141  5                                   3    
HELIX   82 AJ1 PHE B 1145  PHE B 1152  1                                   8    
HELIX   83 AJ2 PHE B 1152  LEU B 1168  1                                  17    
HELIX   84 AJ3 VAL B 1169  PHE B 1178  1                                  10    
HELIX   85 AJ4 SER C   70  LEU C   76  5                                   7    
HELIX   86 AJ5 GLY C   93  ASP C   95  5                                   3    
HELIX   87 AJ6 THR C   99  TRP C  117  1                                  19    
HELIX   88 AJ7 SER C  138  GLY C  143  5                                   6    
HELIX   89 AJ8 ASP C  154  SER C  156  5                                   3    
HELIX   90 AJ9 LYS C  157  GLU C  167  1                                  11    
SHEET    1 AA1 2 MET A 152  PHE A 153  0                                        
SHEET    2 AA1 2 GLY C  29  PHE C  30 -1  O  GLY C  29   N  PHE A 153           
SHEET    1 AA2 3 ILE A 228  ILE A 229  0                                        
SHEET    2 AA2 3 LEU A 354  GLN A 365 -1  O  MET A 363   N  ILE A 229           
SHEET    3 AA2 3 VAL A 343  LYS A 348 -1  N  VAL A 347   O  SER A 356           
SHEET    1 AA3 4 ILE A 228  ILE A 229  0                                        
SHEET    2 AA3 4 LEU A 354  GLN A 365 -1  O  MET A 363   N  ILE A 229           
SHEET    3 AA3 4 PRO A 155  PRO A 162 -1  N  MET A 158   O  THR A 362           
SHEET    4 AA3 4 GLN A 417  PHE A 422 -1  O  LYS A 418   N  THR A 161           
SHEET    1 AA4 2 VAL A 190  MET A 192  0                                        
SHEET    2 AA4 2 ARG A 195  TRP A 197 -1  O  TRP A 197   N  VAL A 190           
SHEET    1 AA5 3 ALA A 972  LEU A 978  0                                        
SHEET    2 AA5 3 TYR A 801  THR A 807 -1  N  TYR A 801   O  LEU A 978           
SHEET    3 AA5 3 SER A1008  GLY A1012 -1  O  ASN A1011   N  TYR A 804           
SHEET    1 AA6 3 ILE B 228  ILE B 229  0                                        
SHEET    2 AA6 3 ALA B 359  MET B 367 -1  O  MET B 363   N  ILE B 229           
SHEET    3 AA6 3 VAL B 343  GLY B 344 -1  N  GLY B 344   O  ALA B 359           
SHEET    1 AA7 4 ILE B 228  ILE B 229  0                                        
SHEET    2 AA7 4 ALA B 359  MET B 367 -1  O  MET B 363   N  ILE B 229           
SHEET    3 AA7 4 PHE B 153  PRO B 162 -1  N  GLN B 156   O  PHE B 364           
SHEET    4 AA7 4 GLN B 417  PHE B 422 -1  O  LEU B 420   N  ILE B 159           
SHEET    1 AA8 2 VAL B 190  MET B 192  0                                        
SHEET    2 AA8 2 ARG B 195  TRP B 197 -1  O  TRP B 197   N  VAL B 190           
SHEET    1 AA9 2 VAL B 347  LYS B 348  0                                        
SHEET    2 AA9 2 LEU B 354  SER B 356 -1  O  SER B 356   N  VAL B 347           
SHEET    1 AB1 3 PHE B 974  LEU B 978  0                                        
SHEET    2 AB1 3 TYR B 801  ILE B 805 -1  N  TYR B 801   O  LEU B 978           
SHEET    3 AB1 3 PRO B1010  GLY B1012 -1  O  ASN B1011   N  TYR B 804           
SHEET    1 AB2 6 PHE C  47  ILE C  48  0                                        
SHEET    2 AB2 6 TRP C 172  TYR C 174 -1  O  VAL C 173   N  ILE C  48           
SHEET    3 AB2 6 ILE C 181  SER C 184 -1  O  HIS C 182   N  TYR C 174           
SHEET    4 AB2 6 ALA C 145  THR C 150 -1  N  VAL C 146   O  CYS C 183           
SHEET    5 AB2 6 LEU C 122  GLU C 126 -1  N  ARG C 123   O  THR C 149           
SHEET    6 AB2 6 ILE C  84  PHE C  86  1  N  ILE C  85   O  LEU C 122           
SHEET    1 AB3 2 THR C  77  PRO C  78  0                                        
SHEET    2 AB3 2 LEU C  97  MET C  98 -1  O  MET C  98   N  THR C  77           
SSBOND   1 CYS A  234    CYS A  327                          1555   1555  2.02  
SSBOND   2 CYS A  296    CYS A  304                          1555   1555  2.03  
SSBOND   3 CYS B  203    CYS B  226                          1555   1555  2.02  
SSBOND   4 CYS B  234    CYS B  327                          1555   1555  2.02  
SSBOND   5 CYS B  296    CYS B  304                          1555   1555  2.05  
LINK         ND2 ASN A 141                 C1  NAG A1508     1555   1555  1.44  
LINK         ND2 ASN A 312                 C1  NAG A1502     1555   1555  1.46  
LINK         ND2 ASN A 349                 C1  NAG A1503     1555   1555  1.43  
LINK         ND2 ASN A 414                 C1  NAG A1504     1555   1555  1.44  
LINK         ND2 ASN A 875                 C1  NAG A1505     1555   1555  1.46  
LINK         ND2 ASN A1000                 C1  NAG D   1     1555   1555  1.43  
LINK         ND2 ASN B 414                 C1  NAG B1503     1555   1555  1.45  
LINK         ND2 ASN B1000                 C1  NAG B1504     1555   1555  1.43  
LINK         N   CYS C  24                 C1  PLM C 201     1555   1555  1.51  
LINK         C   GLY C 197                 O1  CLR C 202     1555   1555  1.37  
LINK         O4  NAG D   1                 C1  NAG D   2     1555   1555  1.45  
LINK         OE1 GLU C  89                CA    CA C 205     1555   1555  2.25  
LINK         OE2 GLU C  89                CA    CA C 205     1555   1555  2.23  
LINK         OE2 GLU C  90                CA    CA C 204     1555   1555  2.17  
LINK         OE1 GLU C  90                CA    CA C 205     1555   1555  2.52  
LINK         OE2 GLU C  90                CA    CA C 205     1555   1555  2.90  
LINK         OD1 ASP C  95                CA    CA C 205     1555   1555  2.36  
LINK         OD2 ASP C  95                CA    CA C 205     1555   1555  2.11  
LINK         O   THR C 125                CA    CA C 205     1555   1555  2.55  
LINK         OE1 GLU C 126                CA    CA C 204     1555   1555  2.34  
LINK         OE2 GLU C 126                CA    CA C 204     1555   1555  2.79  
LINK         OE2 GLU C 126                CA    CA C 205     1555   1555  2.17  
LINK         OD1 ASP C 129                CA    CA C 204     1555   1555  2.15  
LINK         OD2 ASP C 131                CA    CA C 204     1555   1555  2.48  
LINK         NE2 HIS C 140                ZN    ZN C 203     1555   1555  2.19  
LINK         OD1 ASP C 147                ZN    ZN C 203     1555   1555  1.97  
LINK         OD2 ASP C 147                ZN    ZN C 203     1555   1555  2.09  
LINK         OE1 GLU C 176                ZN    ZN C 203     1555   1555  2.21  
LINK         ND1 HIS C 182                ZN    ZN C 203     1555   1555  2.11  
CISPEP   1 ARG A  942    PRO A  943          0         1.82                     
CISPEP   2 ARG B  942    PRO B  943          0         2.61                     
CISPEP   3 ILE C   48    PRO C   49          0        -3.59                     
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1           1          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      1.000000  0.000000  0.000000        0.00000                         
SCALE2      0.000000  1.000000  0.000000        0.00000                         
SCALE3      0.000000  0.000000  1.000000        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
DBGET integrated database retrieval system