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Database: PDB
Entry: 6TM5
LinkDB: 6TM5
Original site: 6TM5 
HEADER    CELL CYCLE                              03-DEC-19   6TM5              
TITLE     CRYO-EM STRUCTURE OF THE ANAPHASE-PROMOTING COMPLEX/CYCLOSOME, IN     
TITLE    2 COMPLEX WITH THE NEK2A SUBSTRATE AT 3.9 ANGSTROM RESOLUTION          
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT 1;                      
COMPND   3 CHAIN: A;                                                            
COMPND   4 SYNONYM: APC1,CYCLOSOME SUBUNIT 1,MITOTIC CHECKPOINT REGULATOR,      
COMPND   5 TESTIS-SPECIFIC GENE 24 PROTEIN;                                     
COMPND   6 ENGINEERED: YES;                                                     
COMPND   7 MOL_ID: 2;                                                           
COMPND   8 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT 11;                     
COMPND   9 CHAIN: B;                                                            
COMPND  10 SYNONYM: APC11,CYCLOSOME SUBUNIT 11,HEPATOCELLULAR CARCINOMA-        
COMPND  11 ASSOCIATED RING FINGER PROTEIN;                                      
COMPND  12 ENGINEERED: YES;                                                     
COMPND  13 MOL_ID: 3;                                                           
COMPND  14 MOLECULE: CELL DIVISION CYCLE PROTEIN 23 HOMOLOG;                    
COMPND  15 CHAIN: C, P;                                                         
COMPND  16 SYNONYM: ANAPHASE-PROMOTING COMPLEX SUBUNIT 8,APC8,CYCLOSOME SUBUNIT 
COMPND  17 8;                                                                   
COMPND  18 ENGINEERED: YES;                                                     
COMPND  19 MOL_ID: 4;                                                           
COMPND  20 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT 15;                     
COMPND  21 CHAIN: D;                                                            
COMPND  22 SYNONYM: APC15;                                                      
COMPND  23 ENGINEERED: YES;                                                     
COMPND  24 MOL_ID: 5;                                                           
COMPND  25 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT 16;                     
COMPND  26 CHAIN: E;                                                            
COMPND  27 SYNONYM: APC16,CYCLOSOME SUBUNIT 16;                                 
COMPND  28 ENGINEERED: YES;                                                     
COMPND  29 MOL_ID: 6;                                                           
COMPND  30 MOLECULE: CELL DIVISION CYCLE PROTEIN 27 HOMOLOG;                    
COMPND  31 CHAIN: F, H;                                                         
COMPND  32 SYNONYM: ANAPHASE-PROMOTING COMPLEX SUBUNIT 3,APC3,CDC27 HOMOLOG,    
COMPND  33 CDC27HS,H-NUC;                                                       
COMPND  34 ENGINEERED: YES;                                                     
COMPND  35 MOL_ID: 7;                                                           
COMPND  36 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT CDC26;                  
COMPND  37 CHAIN: G, W;                                                         
COMPND  38 SYNONYM: ANAPHASE-PROMOTING COMPLEX SUBUNIT 12,APC12,CELL DIVISION   
COMPND  39 CYCLE PROTEIN 26 HOMOLOG;                                            
COMPND  40 ENGINEERED: YES;                                                     
COMPND  41 MOL_ID: 8;                                                           
COMPND  42 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT 4;                      
COMPND  43 CHAIN: I;                                                            
COMPND  44 SYNONYM: APC4,CYCLOSOME SUBUNIT 4;                                   
COMPND  45 ENGINEERED: YES;                                                     
COMPND  46 MOL_ID: 9;                                                           
COMPND  47 MOLECULE: CELL DIVISION CYCLE PROTEIN 16 HOMOLOG;                    
COMPND  48 CHAIN: J, K;                                                         
COMPND  49 SYNONYM: ANAPHASE-PROMOTING COMPLEX SUBUNIT 6,APC6,CDC16 HOMOLOG,    
COMPND  50 CDC16HS,CYCLOSOME SUBUNIT 6;                                         
COMPND  51 ENGINEERED: YES;                                                     
COMPND  52 MOL_ID: 10;                                                          
COMPND  53 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT 10;                     
COMPND  54 CHAIN: L;                                                            
COMPND  55 SYNONYM: APC10,CYCLOSOME SUBUNIT 10;                                 
COMPND  56 ENGINEERED: YES;                                                     
COMPND  57 MOL_ID: 11;                                                          
COMPND  58 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT 13;                     
COMPND  59 CHAIN: M;                                                            
COMPND  60 SYNONYM: APC13,CYCLOSOME SUBUNIT 13;                                 
COMPND  61 ENGINEERED: YES;                                                     
COMPND  62 MOL_ID: 12;                                                          
COMPND  63 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT 2;                      
COMPND  64 CHAIN: N;                                                            
COMPND  65 SYNONYM: APC2,CYCLOSOME SUBUNIT 2;                                   
COMPND  66 ENGINEERED: YES;                                                     
COMPND  67 MOL_ID: 13;                                                          
COMPND  68 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT 5;                      
COMPND  69 CHAIN: O;                                                            
COMPND  70 SYNONYM: APC5,CYCLOSOME SUBUNIT 5;                                   
COMPND  71 ENGINEERED: YES;                                                     
COMPND  72 MOL_ID: 14;                                                          
COMPND  73 MOLECULE: APC1 LOOP;                                                 
COMPND  74 CHAIN: T;                                                            
COMPND  75 ENGINEERED: YES;                                                     
COMPND  76 MOL_ID: 15;                                                          
COMPND  77 MOLECULE: ANAPHASE-PROMOTING COMPLEX SUBUNIT 7;                      
COMPND  78 CHAIN: X, Y;                                                         
COMPND  79 SYNONYM: APC7,CYCLOSOME SUBUNIT 7;                                   
COMPND  80 ENGINEERED: YES;                                                     
COMPND  81 MOL_ID: 16;                                                          
COMPND  82 MOLECULE: SERINE/THREONINE-PROTEIN KINASE NEK2;                      
COMPND  83 CHAIN: S;                                                            
COMPND  84 SYNONYM: HSPK 21,NEVER IN MITOSIS A-RELATED KINASE 2,NIMA-RELATED    
COMPND  85 PROTEIN KINASE 2,NIMA-LIKE PROTEIN KINASE 1;                         
COMPND  86 EC: 2.7.11.1;                                                        
COMPND  87 ENGINEERED: YES;                                                     
COMPND  88 MOL_ID: 17;                                                          
COMPND  89 MOLECULE: SERINE/THREONINE-PROTEIN KINASE NEK2;                      
COMPND  90 CHAIN: Q;                                                            
COMPND  91 SYNONYM: HSPK 21,NEVER IN MITOSIS A-RELATED KINASE 2,NIMA-RELATED    
COMPND  92 PROTEIN KINASE 2,NIMA-LIKE PROTEIN KINASE 1;                         
COMPND  93 EC: 2.7.11.1;                                                        
COMPND  94 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE   3 ORGANISM_COMMON: HUMAN;                                              
SOURCE   4 ORGANISM_TAXID: 9606;                                                
SOURCE   5 GENE: ANAPC1, TSG24;                                                 
SOURCE   6 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;                                  
SOURCE   7 EXPRESSION_SYSTEM_COMMON: CABBAGE LOOPER;                            
SOURCE   8 EXPRESSION_SYSTEM_TAXID: 7111;                                       
SOURCE   9 MOL_ID: 2;                                                           
SOURCE  10 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  11 ORGANISM_COMMON: HUMAN;                                              
SOURCE  12 ORGANISM_TAXID: 9606;                                                
SOURCE  13 GENE: ANAPC11, HSPC214;                                              
SOURCE  14 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;                                  
SOURCE  15 EXPRESSION_SYSTEM_COMMON: CABBAGE LOOPER;                            
SOURCE  16 EXPRESSION_SYSTEM_TAXID: 7111;                                       
SOURCE  17 MOL_ID: 3;                                                           
SOURCE  18 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  19 ORGANISM_COMMON: HUMAN;                                              
SOURCE  20 ORGANISM_TAXID: 9606;                                                
SOURCE  21 GENE: CDC23, ANAPC8;                                                 
SOURCE  22 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;                                  
SOURCE  23 EXPRESSION_SYSTEM_COMMON: CABBAGE LOOPER;                            
SOURCE  24 EXPRESSION_SYSTEM_TAXID: 7111;                                       
SOURCE  25 MOL_ID: 4;                                                           
SOURCE  26 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  27 ORGANISM_COMMON: HUMAN;                                              
SOURCE  28 ORGANISM_TAXID: 9606;                                                
SOURCE  29 GENE: ANAPC15, C11ORF51, HSPC020;                                    
SOURCE  30 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;                                  
SOURCE  31 EXPRESSION_SYSTEM_COMMON: CABBAGE LOOPER;                            
SOURCE  32 EXPRESSION_SYSTEM_TAXID: 7111;                                       
SOURCE  33 MOL_ID: 5;                                                           
SOURCE  34 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  35 ORGANISM_COMMON: HUMAN;                                              
SOURCE  36 ORGANISM_TAXID: 9606;                                                
SOURCE  37 GENE: ANAPC16, C10ORF104, CENP-27;                                   
SOURCE  38 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;                                  
SOURCE  39 EXPRESSION_SYSTEM_COMMON: CABBAGE LOOPER;                            
SOURCE  40 EXPRESSION_SYSTEM_TAXID: 7111;                                       
SOURCE  41 MOL_ID: 6;                                                           
SOURCE  42 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  43 ORGANISM_COMMON: HUMAN;                                              
SOURCE  44 ORGANISM_TAXID: 9606;                                                
SOURCE  45 GENE: CDC27, ANAPC3, D0S1430E, D17S978E;                             
SOURCE  46 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;                                  
SOURCE  47 EXPRESSION_SYSTEM_COMMON: CABBAGE LOOPER;                            
SOURCE  48 EXPRESSION_SYSTEM_TAXID: 7111;                                       
SOURCE  49 MOL_ID: 7;                                                           
SOURCE  50 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  51 ORGANISM_COMMON: HUMAN;                                              
SOURCE  52 ORGANISM_TAXID: 9606;                                                
SOURCE  53 GENE: CDC26, ANAPC12, C9ORF17;                                       
SOURCE  54 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;                                  
SOURCE  55 EXPRESSION_SYSTEM_COMMON: CABBAGE LOOPER;                            
SOURCE  56 EXPRESSION_SYSTEM_TAXID: 7111;                                       
SOURCE  57 MOL_ID: 8;                                                           
SOURCE  58 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  59 ORGANISM_COMMON: HUMAN;                                              
SOURCE  60 ORGANISM_TAXID: 9606;                                                
SOURCE  61 GENE: ANAPC4, APC4;                                                  
SOURCE  62 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;                                  
SOURCE  63 EXPRESSION_SYSTEM_COMMON: CABBAGE LOOPER;                            
SOURCE  64 EXPRESSION_SYSTEM_TAXID: 7111;                                       
SOURCE  65 MOL_ID: 9;                                                           
SOURCE  66 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  67 ORGANISM_COMMON: HUMAN;                                              
SOURCE  68 ORGANISM_TAXID: 9606;                                                
SOURCE  69 GENE: CDC16, ANAPC6;                                                 
SOURCE  70 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;                                  
SOURCE  71 EXPRESSION_SYSTEM_COMMON: CABBAGE LOOPER;                            
SOURCE  72 EXPRESSION_SYSTEM_TAXID: 7111;                                       
SOURCE  73 MOL_ID: 10;                                                          
SOURCE  74 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  75 ORGANISM_COMMON: HUMAN;                                              
SOURCE  76 ORGANISM_TAXID: 9606;                                                
SOURCE  77 GENE: ANAPC10, APC10;                                                
SOURCE  78 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;                                  
SOURCE  79 EXPRESSION_SYSTEM_COMMON: CABBAGE LOOPER;                            
SOURCE  80 EXPRESSION_SYSTEM_TAXID: 7111;                                       
SOURCE  81 MOL_ID: 11;                                                          
SOURCE  82 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  83 ORGANISM_COMMON: HUMAN;                                              
SOURCE  84 ORGANISM_TAXID: 9606;                                                
SOURCE  85 GENE: ANAPC13;                                                       
SOURCE  86 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;                                  
SOURCE  87 EXPRESSION_SYSTEM_COMMON: CABBAGE LOOPER;                            
SOURCE  88 EXPRESSION_SYSTEM_TAXID: 7111;                                       
SOURCE  89 MOL_ID: 12;                                                          
SOURCE  90 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  91 ORGANISM_COMMON: HUMAN;                                              
SOURCE  92 ORGANISM_TAXID: 9606;                                                
SOURCE  93 GENE: ANAPC2, APC2, KIAA1406;                                        
SOURCE  94 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;                                  
SOURCE  95 EXPRESSION_SYSTEM_COMMON: CABBAGE LOOPER;                            
SOURCE  96 EXPRESSION_SYSTEM_TAXID: 7111;                                       
SOURCE  97 MOL_ID: 13;                                                          
SOURCE  98 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE  99 ORGANISM_COMMON: HUMAN;                                              
SOURCE 100 ORGANISM_TAXID: 9606;                                                
SOURCE 101 GENE: ANAPC5, APC5;                                                  
SOURCE 102 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;                                  
SOURCE 103 EXPRESSION_SYSTEM_COMMON: CABBAGE LOOPER;                            
SOURCE 104 EXPRESSION_SYSTEM_TAXID: 7111;                                       
SOURCE 105 MOL_ID: 14;                                                          
SOURCE 106 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE 107 ORGANISM_COMMON: HUMAN;                                              
SOURCE 108 ORGANISM_TAXID: 9606;                                                
SOURCE 109 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;                                  
SOURCE 110 EXPRESSION_SYSTEM_COMMON: CABBAGE LOOPER;                            
SOURCE 111 EXPRESSION_SYSTEM_TAXID: 7111;                                       
SOURCE 112 MOL_ID: 15;                                                          
SOURCE 113 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE 114 ORGANISM_COMMON: HUMAN;                                              
SOURCE 115 ORGANISM_TAXID: 9606;                                                
SOURCE 116 GENE: ANAPC7, APC7;                                                  
SOURCE 117 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;                                  
SOURCE 118 EXPRESSION_SYSTEM_COMMON: CABBAGE LOOPER;                            
SOURCE 119 EXPRESSION_SYSTEM_TAXID: 7111;                                       
SOURCE 120 MOL_ID: 16;                                                          
SOURCE 121 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE 122 ORGANISM_COMMON: HUMAN;                                              
SOURCE 123 ORGANISM_TAXID: 9606;                                                
SOURCE 124 GENE: NEK2, NEK2A, NLK1;                                             
SOURCE 125 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;                                  
SOURCE 126 EXPRESSION_SYSTEM_COMMON: CABBAGE LOOPER;                            
SOURCE 127 EXPRESSION_SYSTEM_TAXID: 7111;                                       
SOURCE 128 MOL_ID: 17;                                                          
SOURCE 129 ORGANISM_SCIENTIFIC: HOMO SAPIENS;                                   
SOURCE 130 ORGANISM_COMMON: HUMAN;                                              
SOURCE 131 ORGANISM_TAXID: 9606;                                                
SOURCE 132 GENE: NEK2, NEK2A, NLK1;                                             
SOURCE 133 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;                                  
SOURCE 134 EXPRESSION_SYSTEM_COMMON: CABBAGE LOOPER;                            
SOURCE 135 EXPRESSION_SYSTEM_TAXID: 7111                                        
KEYWDS    E3 UBIQUITIN LIGASE, COMPLEX, CELL CYCLE                              
EXPDTA    ELECTRON MICROSCOPY                                                   
AUTHOR    C.ALFIERI,D.BARFORD                                                   
REVDAT   3   17-JUN-20 6TM5    1       JRNL                                     
REVDAT   2   29-APR-20 6TM5    1       JRNL                                     
REVDAT   1   19-FEB-20 6TM5    0                                                
JRNL        AUTH   C.ALFIERI,T.TISCHER,D.BARFORD                                
JRNL        TITL   A UNIQUE BINDING MODE OF NEK2A TO THE APC/C ALLOWS ITS       
JRNL        TITL 2 UBIQUITINATION DURING PROMETAPHASE.                          
JRNL        REF    EMBO REP.                     V.  21 49831 2020              
JRNL        REFN                   ESSN 1469-3178                               
JRNL        PMID   32307883                                                     
JRNL        DOI    10.15252/EMBR.201949831                                      
REMARK   2                                                                      
REMARK   2 RESOLUTION.    3.90 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   SOFTWARE PACKAGES      : NULL                                      
REMARK   3   RECONSTRUCTION SCHEMA  : NULL                                      
REMARK   3                                                                      
REMARK   3 EM MAP-MODEL FITTING AND REFINEMENT                                  
REMARK   3   PDB ENTRY                    : NULL                                
REMARK   3   REFINEMENT SPACE             : NULL                                
REMARK   3   REFINEMENT PROTOCOL          : NULL                                
REMARK   3   REFINEMENT TARGET            : NULL                                
REMARK   3   OVERALL ANISOTROPIC B VALUE  : NULL                                
REMARK   3                                                                      
REMARK   3 FITTING PROCEDURE : NULL                                             
REMARK   3                                                                      
REMARK   3 EM IMAGE RECONSTRUCTION STATISTICS                                   
REMARK   3   NOMINAL PIXEL SIZE (ANGSTROMS)    : NULL                           
REMARK   3   ACTUAL PIXEL SIZE  (ANGSTROMS)    : NULL                           
REMARK   3   EFFECTIVE RESOLUTION (ANGSTROMS)  : 3.900                          
REMARK   3   NUMBER OF PARTICLES               : 233840                         
REMARK   3   CTF CORRECTION METHOD             : PHASE FLIPPING AND AMPLITUDE   
REMARK   3                                       CORRECTION                     
REMARK   3                                                                      
REMARK   3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL                    
REMARK   3                                                                      
REMARK   3 OTHER DETAILS: NULL                                                  
REMARK   4                                                                      
REMARK   4 6TM5 COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 04-DEC-19.                  
REMARK 100 THE DEPOSITION ID IS D_1292105666.                                   
REMARK 245                                                                      
REMARK 245 EXPERIMENTAL DETAILS                                                 
REMARK 245   RECONSTRUCTION METHOD          : SINGLE PARTICLE                   
REMARK 245   SPECIMEN TYPE                  : NULL                              
REMARK 245                                                                      
REMARK 245 ELECTRON MICROSCOPE SAMPLE                                           
REMARK 245   SAMPLE TYPE                    : PARTICLE                          
REMARK 245   PARTICLE TYPE                  : POINT                             
REMARK 245   NAME OF SAMPLE                 : CRYO-EM STRUCTURE OF THE          
REMARK 245                                    ANAPHASE-PROMOTING COMPLEX/       
REMARK 245                                    CYCLOSOME, IN COMPLEX WITH THE    
REMARK 245                                    NEK2A SUBSTRATE AT 3.9 ANGSTROM   
REMARK 245                                    RESOLUTION                        
REMARK 245   SAMPLE CONCENTRATION (MG ML-1) : NULL                              
REMARK 245   SAMPLE SUPPORT DETAILS         : NULL                              
REMARK 245   SAMPLE VITRIFICATION DETAILS   : NULL                              
REMARK 245   SAMPLE BUFFER                  : NULL                              
REMARK 245   PH                             : 8.00                              
REMARK 245   SAMPLE DETAILS                 : NULL                              
REMARK 245                                                                      
REMARK 245 DATA ACQUISITION                                                     
REMARK 245   DATE OF EXPERIMENT                : NULL                           
REMARK 245   NUMBER OF MICROGRAPHS-IMAGES      : NULL                           
REMARK 245   TEMPERATURE (KELVIN)              : NULL                           
REMARK 245   MICROSCOPE MODEL                  : FEI TITAN KRIOS                
REMARK 245   DETECTOR TYPE                     : GATAN K2 SUMMIT (4K X 4K)      
REMARK 245   MINIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MAXIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MINIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   MAXIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   NOMINAL CS                        : NULL                           
REMARK 245   IMAGING MODE                      : BRIGHT FIELD                   
REMARK 245   ELECTRON DOSE (ELECTRONS NM**-2)  : 29.00                          
REMARK 245   ILLUMINATION MODE                 : FLOOD BEAM                     
REMARK 245   NOMINAL MAGNIFICATION             : NULL                           
REMARK 245   CALIBRATED MAGNIFICATION          : NULL                           
REMARK 245   SOURCE                            : FIELD EMISSION GUN             
REMARK 245   ACCELERATION VOLTAGE (KV)         : 300                            
REMARK 245   IMAGING DETAILS                   : NULL                           
REMARK 247                                                                      
REMARK 247 ELECTRON MICROSCOPY                                                  
REMARK 247  THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON          
REMARK 247  MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE              
REMARK 247  THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES           
REMARK 247  ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION         
REMARK 247  OF THE STRUCTURE FACTORS.                                           
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: 22-MERIC                          
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E, F, G, H, I, J,         
REMARK 350                    AND CHAINS: K, L, M, N, O, P, T, W, X,            
REMARK 350                    AND CHAINS: Y, S, Q                               
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     MET A     1                                                      
REMARK 465     SER A     2                                                      
REMARK 465     ASN A     3                                                      
REMARK 465     PHE A     4                                                      
REMARK 465     TYR A     5                                                      
REMARK 465     GLU A     6                                                      
REMARK 465     GLU A     7                                                      
REMARK 465     ARG A     8                                                      
REMARK 465     THR A     9                                                      
REMARK 465     THR A    10                                                      
REMARK 465     LEU A    35                                                      
REMARK 465     ASN A    36                                                      
REMARK 465     LEU A    37                                                      
REMARK 465     GLN A    38                                                      
REMARK 465     LEU A    39                                                      
REMARK 465     ARG A    40                                                      
REMARK 465     GLN A    41                                                      
REMARK 465     LEU A    42                                                      
REMARK 465     GLN A    43                                                      
REMARK 465     PRO A    44                                                      
REMARK 465     ALA A    45                                                      
REMARK 465     SER A    46                                                      
REMARK 465     GLU A    47                                                      
REMARK 465     LEU A    48                                                      
REMARK 465     TRP A    49                                                      
REMARK 465     SER A    50                                                      
REMARK 465     SER A    51                                                      
REMARK 465     ASP A    52                                                      
REMARK 465     GLY A    53                                                      
REMARK 465     ALA A    54                                                      
REMARK 465     ALA A    55                                                      
REMARK 465     GLY A    56                                                      
REMARK 465     LEU A    57                                                      
REMARK 465     VAL A    58                                                      
REMARK 465     GLY A    59                                                      
REMARK 465     SER A    60                                                      
REMARK 465     LEU A    61                                                      
REMARK 465     GLN A    62                                                      
REMARK 465     GLU A    63                                                      
REMARK 465     VAL A    64                                                      
REMARK 465     THR A    65                                                      
REMARK 465     ILE A    66                                                      
REMARK 465     HIS A    67                                                      
REMARK 465     GLU A    68                                                      
REMARK 465     LYS A    69                                                      
REMARK 465     GLN A    70                                                      
REMARK 465     SER A   194                                                      
REMARK 465     SER A   195                                                      
REMARK 465     HIS A   196                                                      
REMARK 465     GLU A   197                                                      
REMARK 465     VAL A   198                                                      
REMARK 465     PRO A   199                                                      
REMARK 465     PRO A   200                                                      
REMARK 465     GLY A   201                                                      
REMARK 465     SER A   202                                                      
REMARK 465     PRO A   203                                                      
REMARK 465     ARG A   204                                                      
REMARK 465     GLU A   205                                                      
REMARK 465     SER A   227                                                      
REMARK 465     GLY A   228                                                      
REMARK 465     SER A   229                                                      
REMARK 465     LEU A   230                                                      
REMARK 465     PHE A   231                                                      
REMARK 465     GLY A   232                                                      
REMARK 465     SER A   233                                                      
REMARK 465     VAL A   282                                                      
REMARK 465     LEU A   283                                                      
REMARK 465     LYS A   284                                                      
REMARK 465     PHE A   285                                                      
REMARK 465     SER A   286                                                      
REMARK 465     GLU A   287                                                      
REMARK 465     GLN A   288                                                      
REMARK 465     GLY A   289                                                      
REMARK 465     GLY A   290                                                      
REMARK 465     THR A   291                                                      
REMARK 465     PRO A   292                                                      
REMARK 465     GLN A   293                                                      
REMARK 465     ASN A   294                                                      
REMARK 465     VAL A   295                                                      
REMARK 465     ALA A   296                                                      
REMARK 465     THR A   297                                                      
REMARK 465     SER A   298                                                      
REMARK 465     SER A   299                                                      
REMARK 465     SER A   300                                                      
REMARK 465     LEU A   301                                                      
REMARK 465     THR A   302                                                      
REMARK 465     ALA A   303                                                      
REMARK 465     HIS A   304                                                      
REMARK 465     LEU A   305                                                      
REMARK 465     ARG A   306                                                      
REMARK 465     SER A   307                                                      
REMARK 465     LEU A   308                                                      
REMARK 465     SER A   309                                                      
REMARK 465     LYS A   310                                                      
REMARK 465     GLY A   311                                                      
REMARK 465     ASP A   312                                                      
REMARK 465     SER A   313                                                      
REMARK 465     PRO A   314                                                      
REMARK 465     VAL A   315                                                      
REMARK 465     THR A   316                                                      
REMARK 465     SER A   317                                                      
REMARK 465     PRO A   318                                                      
REMARK 465     PHE A   319                                                      
REMARK 465     GLN A   320                                                      
REMARK 465     ASN A   321                                                      
REMARK 465     TYR A   322                                                      
REMARK 465     SER A   323                                                      
REMARK 465     SER A   324                                                      
REMARK 465     ILE A   325                                                      
REMARK 465     HIS A   326                                                      
REMARK 465     SER A   327                                                      
REMARK 465     GLN A   328                                                      
REMARK 465     SER A   329                                                      
REMARK 465     ARG A   330                                                      
REMARK 465     SER A   331                                                      
REMARK 465     THR A   332                                                      
REMARK 465     SER A   333                                                      
REMARK 465     SER A   334                                                      
REMARK 465     PRO A   335                                                      
REMARK 465     SER A   336                                                      
REMARK 465     LEU A   337                                                      
REMARK 465     HIS A   338                                                      
REMARK 465     SER A   339                                                      
REMARK 465     ARG A   340                                                      
REMARK 465     SER A   341                                                      
REMARK 465     PRO A   342                                                      
REMARK 465     SER A   343                                                      
REMARK 465     ILE A   344                                                      
REMARK 465     SER A   345                                                      
REMARK 465     ASN A   346                                                      
REMARK 465     MET A   347                                                      
REMARK 465     ALA A   348                                                      
REMARK 465     ALA A   349                                                      
REMARK 465     LEU A   350                                                      
REMARK 465     SER A   351                                                      
REMARK 465     ARG A   352                                                      
REMARK 465     ALA A   353                                                      
REMARK 465     HIS A   354                                                      
REMARK 465     SER A   355                                                      
REMARK 465     PHE A   356                                                      
REMARK 465     ALA A   357                                                      
REMARK 465     LEU A   358                                                      
REMARK 465     GLY A   359                                                      
REMARK 465     VAL A   360                                                      
REMARK 465     HIS A   361                                                      
REMARK 465     SER A   362                                                      
REMARK 465     PHE A   363                                                      
REMARK 465     SER A   364                                                      
REMARK 465     GLY A   365                                                      
REMARK 465     VAL A   366                                                      
REMARK 465     GLN A   367                                                      
REMARK 465     ARG A   368                                                      
REMARK 465     PHE A   369                                                      
REMARK 465     ASN A   370                                                      
REMARK 465     ILE A   371                                                      
REMARK 465     SER A   372                                                      
REMARK 465     SER A   373                                                      
REMARK 465     HIS A   374                                                      
REMARK 465     ASN A   375                                                      
REMARK 465     GLN A   376                                                      
REMARK 465     SER A   377                                                      
REMARK 465     PRO A   378                                                      
REMARK 465     LYS A   379                                                      
REMARK 465     ARG A   380                                                      
REMARK 465     HIS A   381                                                      
REMARK 465     SER A   382                                                      
REMARK 465     ILE A   383                                                      
REMARK 465     SER A   384                                                      
REMARK 465     HIS A   385                                                      
REMARK 465     SER A   386                                                      
REMARK 465     PRO A   387                                                      
REMARK 465     ASN A   388                                                      
REMARK 465     SER A   389                                                      
REMARK 465     ASN A   390                                                      
REMARK 465     SER A   391                                                      
REMARK 465     ASN A   392                                                      
REMARK 465     GLY A   393                                                      
REMARK 465     SER A   394                                                      
REMARK 465     PHE A   395                                                      
REMARK 465     LEU A   396                                                      
REMARK 465     ALA A   397                                                      
REMARK 465     PRO A   398                                                      
REMARK 465     GLU A   399                                                      
REMARK 465     THR A   400                                                      
REMARK 465     GLU A   401                                                      
REMARK 465     PRO A   402                                                      
REMARK 465     ILE A   417                                                      
REMARK 465     THR A   418                                                      
REMARK 465     ASN A   419                                                      
REMARK 465     ILE A   420                                                      
REMARK 465     ARG A   421                                                      
REMARK 465     ALA A   516                                                      
REMARK 465     PRO A   517                                                      
REMARK 465     SER A   518                                                      
REMARK 465     LEU A   519                                                      
REMARK 465     THR A   520                                                      
REMARK 465     MET A   521                                                      
REMARK 465     SER A   522                                                      
REMARK 465     ASN A   523                                                      
REMARK 465     THR A   524                                                      
REMARK 465     MET A   525                                                      
REMARK 465     PRO A   526                                                      
REMARK 465     ARG A   527                                                      
REMARK 465     PRO A   528                                                      
REMARK 465     SER A   529                                                      
REMARK 465     THR A   530                                                      
REMARK 465     PRO A   531                                                      
REMARK 465     LEU A   532                                                      
REMARK 465     ASP A   533                                                      
REMARK 465     GLY A   534                                                      
REMARK 465     VAL A   535                                                      
REMARK 465     SER A   536                                                      
REMARK 465     THR A   537                                                      
REMARK 465     PRO A   538                                                      
REMARK 465     LYS A   539                                                      
REMARK 465     PRO A   540                                                      
REMARK 465     LEU A   541                                                      
REMARK 465     SER A   542                                                      
REMARK 465     LYS A   543                                                      
REMARK 465     LEU A   544                                                      
REMARK 465     LEU A   545                                                      
REMARK 465     GLY A   546                                                      
REMARK 465     SER A   547                                                      
REMARK 465     LEU A   548                                                      
REMARK 465     ASP A   549                                                      
REMARK 465     GLU A   550                                                      
REMARK 465     VAL A   551                                                      
REMARK 465     VAL A   552                                                      
REMARK 465     LEU A   553                                                      
REMARK 465     LEU A   554                                                      
REMARK 465     SER A   555                                                      
REMARK 465     PRO A   556                                                      
REMARK 465     VAL A   557                                                      
REMARK 465     PRO A   558                                                      
REMARK 465     GLU A   559                                                      
REMARK 465     LEU A   560                                                      
REMARK 465     ARG A   561                                                      
REMARK 465     ASP A   562                                                      
REMARK 465     SER A   563                                                      
REMARK 465     SER A   564                                                      
REMARK 465     LYS A   565                                                      
REMARK 465     LEU A   566                                                      
REMARK 465     HIS A   567                                                      
REMARK 465     ASP A   568                                                      
REMARK 465     SER A   569                                                      
REMARK 465     LEU A   570                                                      
REMARK 465     TYR A   571                                                      
REMARK 465     ASN A   572                                                      
REMARK 465     GLU A   573                                                      
REMARK 465     ASP A   574                                                      
REMARK 465     CYS A   575                                                      
REMARK 465     THR A   576                                                      
REMARK 465     PHE A   577                                                      
REMARK 465     GLN A   578                                                      
REMARK 465     ARG A   679                                                      
REMARK 465     ASN A   680                                                      
REMARK 465     PHE A   681                                                      
REMARK 465     ASP A   682                                                      
REMARK 465     PHE A   683                                                      
REMARK 465     GLU A   684                                                      
REMARK 465     GLY A   685                                                      
REMARK 465     SER A   686                                                      
REMARK 465     LEU A   687                                                      
REMARK 465     SER A   688                                                      
REMARK 465     PRO A   689                                                      
REMARK 465     VAL A   690                                                      
REMARK 465     ILE A   691                                                      
REMARK 465     ALA A   692                                                      
REMARK 465     PRO A   693                                                      
REMARK 465     LYS A   694                                                      
REMARK 465     LYS A   695                                                      
REMARK 465     ALA A   696                                                      
REMARK 465     ARG A   697                                                      
REMARK 465     PRO A   698                                                      
REMARK 465     SER A   699                                                      
REMARK 465     GLU A   700                                                      
REMARK 465     THR A   701                                                      
REMARK 465     GLY A   702                                                      
REMARK 465     SER A   703                                                      
REMARK 465     PRO A   732                                                      
REMARK 465     SER A   733                                                      
REMARK 465     GLU A   734                                                      
REMARK 465     ALA A   735                                                      
REMARK 465     SER A   736                                                      
REMARK 465     GLN A   737                                                      
REMARK 465     MET A   738                                                      
REMARK 465     LYS A   739                                                      
REMARK 465     ASP A   740                                                      
REMARK 465     GLU A   741                                                      
REMARK 465     ASP A   742                                                      
REMARK 465     PHE A   743                                                      
REMARK 465     SER A   744                                                      
REMARK 465     GLN A   745                                                      
REMARK 465     ASN A   746                                                      
REMARK 465     VAL A   888                                                      
REMARK 465     SER A   889                                                      
REMARK 465     ASP A   890                                                      
REMARK 465     GLU A   891                                                      
REMARK 465     ILE A   901                                                      
REMARK 465     ALA A   902                                                      
REMARK 465     PRO A   903                                                      
REMARK 465     GLN A   904                                                      
REMARK 465     LYS A   905                                                      
REMARK 465     LEU A   906                                                      
REMARK 465     GLN A   907                                                      
REMARK 465     VAL A   908                                                      
REMARK 465     GLU A   909                                                      
REMARK 465     GLN A   910                                                      
REMARK 465     GLU A   911                                                      
REMARK 465     GLU A   912                                                      
REMARK 465     ASN A   913                                                      
REMARK 465     ARG A   914                                                      
REMARK 465     PHE A   915                                                      
REMARK 465     SER A   916                                                      
REMARK 465     PHE A   917                                                      
REMARK 465     ARG A   918                                                      
REMARK 465     HIS A   919                                                      
REMARK 465     SER A   920                                                      
REMARK 465     THR A   921                                                      
REMARK 465     SER A   922                                                      
REMARK 465     LYS A   994                                                      
REMARK 465     GLY A   995                                                      
REMARK 465     LYS A   996                                                      
REMARK 465     SER A   997                                                      
REMARK 465     VAL A   998                                                      
REMARK 465     LEU A   999                                                      
REMARK 465     SER A  1000                                                      
REMARK 465     SER A  1001                                                      
REMARK 465     ASP A  1002                                                      
REMARK 465     VAL A  1003                                                      
REMARK 465     PRO A  1004                                                      
REMARK 465     SER A  1005                                                      
REMARK 465     GLY A  1006                                                      
REMARK 465     THR A  1007                                                      
REMARK 465     GLU A  1008                                                      
REMARK 465     THR A  1009                                                      
REMARK 465     GLU A  1010                                                      
REMARK 465     ARG A  1334                                                      
REMARK 465     ARG A  1335                                                      
REMARK 465     PHE A  1336                                                      
REMARK 465     GLN A  1337                                                      
REMARK 465     THR A  1338                                                      
REMARK 465     GLY A  1339                                                      
REMARK 465     MET A  1340                                                      
REMARK 465     HIS A  1341                                                      
REMARK 465     ARG A  1342                                                      
REMARK 465     GLU A  1343                                                      
REMARK 465     LYS A  1344                                                      
REMARK 465     HIS A  1345                                                      
REMARK 465     LYS A  1346                                                      
REMARK 465     SER A  1440                                                      
REMARK 465     LEU A  1441                                                      
REMARK 465     SER A  1442                                                      
REMARK 465     GLU A  1443                                                      
REMARK 465     ILE A  1444                                                      
REMARK 465     GLU A  1445                                                      
REMARK 465     LEU A  1446                                                      
REMARK 465     PRO A  1447                                                      
REMARK 465     CYS A  1448                                                      
REMARK 465     SER A  1449                                                      
REMARK 465     GLU A  1450                                                      
REMARK 465     ASP A  1451                                                      
REMARK 465     ILE A  1903                                                      
REMARK 465     GLY A  1904                                                      
REMARK 465     LEU A  1905                                                      
REMARK 465     GLU A  1906                                                      
REMARK 465     GLY A  1907                                                      
REMARK 465     GLY A  1937                                                      
REMARK 465     ASN A  1938                                                      
REMARK 465     PRO A  1939                                                      
REMARK 465     GLN A  1940                                                      
REMARK 465     PRO A  1941                                                      
REMARK 465     MET A  1942                                                      
REMARK 465     VAL A  1943                                                      
REMARK 465     MET A  1944                                                      
REMARK 465     MET C     1                                                      
REMARK 465     ALA C     2                                                      
REMARK 465     ALA C     3                                                      
REMARK 465     SER C     4                                                      
REMARK 465     THR C     5                                                      
REMARK 465     SER C     6                                                      
REMARK 465     MET C     7                                                      
REMARK 465     VAL C     8                                                      
REMARK 465     PRO C     9                                                      
REMARK 465     VAL C    10                                                      
REMARK 465     ALA C    11                                                      
REMARK 465     VAL C    12                                                      
REMARK 465     THR C    13                                                      
REMARK 465     ALA C    14                                                      
REMARK 465     ALA C    15                                                      
REMARK 465     VAL C    16                                                      
REMARK 465     ALA C    17                                                      
REMARK 465     PRO C    18                                                      
REMARK 465     VAL C    19                                                      
REMARK 465     LEU C    20                                                      
REMARK 465     SER C    21                                                      
REMARK 465     ILE C    22                                                      
REMARK 465     ASN C    23                                                      
REMARK 465     SER C    24                                                      
REMARK 465     ASP C    25                                                      
REMARK 465     GLY C   501                                                      
REMARK 465     GLU C   502                                                      
REMARK 465     ILE C   503                                                      
REMARK 465     VAL C   504                                                      
REMARK 465     GLU C   505                                                      
REMARK 465     HIS C   506                                                      
REMARK 465     LEU C   507                                                      
REMARK 465     GLU C   508                                                      
REMARK 465     ASN C   558                                                      
REMARK 465     GLN C   559                                                      
REMARK 465     GLY C   560                                                      
REMARK 465     GLU C   561                                                      
REMARK 465     THR C   562                                                      
REMARK 465     PRO C   563                                                      
REMARK 465     THR C   564                                                      
REMARK 465     THR C   565                                                      
REMARK 465     GLU C   566                                                      
REMARK 465     VAL C   567                                                      
REMARK 465     PRO C   568                                                      
REMARK 465     ALA C   569                                                      
REMARK 465     PRO C   570                                                      
REMARK 465     PHE C   571                                                      
REMARK 465     PHE C   572                                                      
REMARK 465     LEU C   573                                                      
REMARK 465     PRO C   574                                                      
REMARK 465     ALA C   575                                                      
REMARK 465     SER C   576                                                      
REMARK 465     LEU C   577                                                      
REMARK 465     SER C   578                                                      
REMARK 465     ALA C   579                                                      
REMARK 465     ASN C   580                                                      
REMARK 465     ASN C   581                                                      
REMARK 465     THR C   582                                                      
REMARK 465     PRO C   583                                                      
REMARK 465     THR C   584                                                      
REMARK 465     ARG C   585                                                      
REMARK 465     ARG C   586                                                      
REMARK 465     VAL C   587                                                      
REMARK 465     SER C   588                                                      
REMARK 465     PRO C   589                                                      
REMARK 465     LEU C   590                                                      
REMARK 465     ASN C   591                                                      
REMARK 465     LEU C   592                                                      
REMARK 465     SER C   593                                                      
REMARK 465     SER C   594                                                      
REMARK 465     VAL C   595                                                      
REMARK 465     THR C   596                                                      
REMARK 465     PRO C   597                                                      
REMARK 465     MET D     1                                                      
REMARK 465     PRO D    57                                                      
REMARK 465     ALA D    58                                                      
REMARK 465     SER D    59                                                      
REMARK 465     GLU D    60                                                      
REMARK 465     HIS D    61                                                      
REMARK 465     TYR D    62                                                      
REMARK 465     ASP D    63                                                      
REMARK 465     ASP D    64                                                      
REMARK 465     GLU D    65                                                      
REMARK 465     GLU D    66                                                      
REMARK 465     GLU D    67                                                      
REMARK 465     GLU D    68                                                      
REMARK 465     ASP D    69                                                      
REMARK 465     ASP D    70                                                      
REMARK 465     GLU D    71                                                      
REMARK 465     ASP D    72                                                      
REMARK 465     ASP D    73                                                      
REMARK 465     GLU D    74                                                      
REMARK 465     ASP D    75                                                      
REMARK 465     SER D    76                                                      
REMARK 465     GLU D    77                                                      
REMARK 465     GLU D    78                                                      
REMARK 465     ASP D    79                                                      
REMARK 465     SER D    80                                                      
REMARK 465     GLU D    81                                                      
REMARK 465     ASP D    82                                                      
REMARK 465     ASP D    83                                                      
REMARK 465     GLU D    84                                                      
REMARK 465     ASP D    85                                                      
REMARK 465     MET D    86                                                      
REMARK 465     GLN D    87                                                      
REMARK 465     ASP D    88                                                      
REMARK 465     MET D    89                                                      
REMARK 465     ASP D    90                                                      
REMARK 465     GLU D    91                                                      
REMARK 465     MET D    92                                                      
REMARK 465     ASN D    93                                                      
REMARK 465     ASP D    94                                                      
REMARK 465     TYR D    95                                                      
REMARK 465     ASN D    96                                                      
REMARK 465     GLU D    97                                                      
REMARK 465     SER D    98                                                      
REMARK 465     PRO D    99                                                      
REMARK 465     ASP D   100                                                      
REMARK 465     ASP D   101                                                      
REMARK 465     GLY D   102                                                      
REMARK 465     GLU D   103                                                      
REMARK 465     VAL D   104                                                      
REMARK 465     ASN D   105                                                      
REMARK 465     GLU D   106                                                      
REMARK 465     VAL D   107                                                      
REMARK 465     ASP D   108                                                      
REMARK 465     MET D   109                                                      
REMARK 465     GLU D   110                                                      
REMARK 465     GLY D   111                                                      
REMARK 465     ASN D   112                                                      
REMARK 465     GLU D   113                                                      
REMARK 465     GLN D   114                                                      
REMARK 465     ASP D   115                                                      
REMARK 465     GLN D   116                                                      
REMARK 465     ASP D   117                                                      
REMARK 465     GLN D   118                                                      
REMARK 465     TRP D   119                                                      
REMARK 465     MET D   120                                                      
REMARK 465     ILE D   121                                                      
REMARK 465     MET E     1                                                      
REMARK 465     ALA E     2                                                      
REMARK 465     ALA E     3                                                      
REMARK 465     SER E     4                                                      
REMARK 465     SER E     5                                                      
REMARK 465     SER E     6                                                      
REMARK 465     SER E     7                                                      
REMARK 465     SER E     8                                                      
REMARK 465     SER E     9                                                      
REMARK 465     ALA E    10                                                      
REMARK 465     GLY E    11                                                      
REMARK 465     GLY E    12                                                      
REMARK 465     VAL E    13                                                      
REMARK 465     SER E    14                                                      
REMARK 465     GLY E    15                                                      
REMARK 465     SER E    16                                                      
REMARK 465     SER E    17                                                      
REMARK 465     VAL E    18                                                      
REMARK 465     THR E    19                                                      
REMARK 465     GLY E    20                                                      
REMARK 465     SER E    21                                                      
REMARK 465     GLY E    22                                                      
REMARK 465     PHE E    23                                                      
REMARK 465     SER E    24                                                      
REMARK 465     VAL E    25                                                      
REMARK 465     SER E    26                                                      
REMARK 465     ASP E    27                                                      
REMARK 465     LEU E    28                                                      
REMARK 465     ALA E    29                                                      
REMARK 465     PRO E    30                                                      
REMARK 465     PRO E    31                                                      
REMARK 465     ARG E    32                                                      
REMARK 465     LYS E    33                                                      
REMARK 465     ALA E    34                                                      
REMARK 465     LEU E    35                                                      
REMARK 465     PHE E    36                                                      
REMARK 465     THR E    37                                                      
REMARK 465     TYR E    38                                                      
REMARK 465     PRO E    39                                                      
REMARK 465     LYS E    40                                                      
REMARK 465     GLY E    41                                                      
REMARK 465     ALA E    42                                                      
REMARK 465     GLY E    43                                                      
REMARK 465     GLU E    44                                                      
REMARK 465     MET E    45                                                      
REMARK 465     LEU E    46                                                      
REMARK 465     GLU E    47                                                      
REMARK 465     ASP E    48                                                      
REMARK 465     GLY E    49                                                      
REMARK 465     SER E    50                                                      
REMARK 465     GLU E    51                                                      
REMARK 465     SER E   108                                                      
REMARK 465     SER E   109                                                      
REMARK 465     GLY E   110                                                      
REMARK 465     MET F     1                                                      
REMARK 465     THR F     2                                                      
REMARK 465     VAL F     3                                                      
REMARK 465     LEU F     4                                                      
REMARK 465     SER F   172                                                      
REMARK 465     LEU F   173                                                      
REMARK 465     GLN F   174                                                      
REMARK 465     ASN F   175                                                      
REMARK 465     PHE F   176                                                      
REMARK 465     SER F   177                                                      
REMARK 465     ASN F   178                                                      
REMARK 465     CYS F   179                                                      
REMARK 465     LEU F   180                                                      
REMARK 465     PRO F   181                                                      
REMARK 465     ASN F   182                                                      
REMARK 465     SER F   183                                                      
REMARK 465     CYS F   184                                                      
REMARK 465     THR F   185                                                      
REMARK 465     THR F   186                                                      
REMARK 465     GLN F   187                                                      
REMARK 465     VAL F   188                                                      
REMARK 465     PRO F   189                                                      
REMARK 465     ASN F   190                                                      
REMARK 465     HIS F   191                                                      
REMARK 465     SER F   192                                                      
REMARK 465     LEU F   193                                                      
REMARK 465     SER F   194                                                      
REMARK 465     HIS F   195                                                      
REMARK 465     ARG F   196                                                      
REMARK 465     GLN F   197                                                      
REMARK 465     PRO F   198                                                      
REMARK 465     GLU F   199                                                      
REMARK 465     THR F   200                                                      
REMARK 465     VAL F   201                                                      
REMARK 465     LEU F   202                                                      
REMARK 465     THR F   203                                                      
REMARK 465     GLU F   204                                                      
REMARK 465     THR F   205                                                      
REMARK 465     PRO F   206                                                      
REMARK 465     GLN F   207                                                      
REMARK 465     ASP F   208                                                      
REMARK 465     THR F   209                                                      
REMARK 465     ILE F   210                                                      
REMARK 465     GLU F   211                                                      
REMARK 465     LEU F   212                                                      
REMARK 465     ASN F   213                                                      
REMARK 465     ARG F   214                                                      
REMARK 465     LEU F   215                                                      
REMARK 465     ASN F   216                                                      
REMARK 465     LEU F   217                                                      
REMARK 465     GLU F   218                                                      
REMARK 465     SER F   219                                                      
REMARK 465     SER F   220                                                      
REMARK 465     ASN F   221                                                      
REMARK 465     SER F   222                                                      
REMARK 465     LYS F   223                                                      
REMARK 465     TYR F   224                                                      
REMARK 465     SER F   225                                                      
REMARK 465     LEU F   226                                                      
REMARK 465     ASN F   227                                                      
REMARK 465     THR F   228                                                      
REMARK 465     ASP F   229                                                      
REMARK 465     SER F   230                                                      
REMARK 465     SER F   231                                                      
REMARK 465     VAL F   232                                                      
REMARK 465     SER F   233                                                      
REMARK 465     TYR F   234                                                      
REMARK 465     ILE F   235                                                      
REMARK 465     ASP F   236                                                      
REMARK 465     SER F   237                                                      
REMARK 465     ALA F   238                                                      
REMARK 465     VAL F   239                                                      
REMARK 465     ILE F   240                                                      
REMARK 465     SER F   241                                                      
REMARK 465     PRO F   242                                                      
REMARK 465     ASP F   243                                                      
REMARK 465     THR F   244                                                      
REMARK 465     VAL F   245                                                      
REMARK 465     PRO F   246                                                      
REMARK 465     LEU F   247                                                      
REMARK 465     GLY F   248                                                      
REMARK 465     THR F   249                                                      
REMARK 465     GLY F   250                                                      
REMARK 465     THR F   251                                                      
REMARK 465     SER F   252                                                      
REMARK 465     ILE F   253                                                      
REMARK 465     LEU F   254                                                      
REMARK 465     SER F   255                                                      
REMARK 465     LYS F   256                                                      
REMARK 465     GLN F   257                                                      
REMARK 465     VAL F   258                                                      
REMARK 465     GLN F   259                                                      
REMARK 465     ASN F   260                                                      
REMARK 465     LYS F   261                                                      
REMARK 465     PRO F   262                                                      
REMARK 465     LYS F   263                                                      
REMARK 465     THR F   264                                                      
REMARK 465     GLY F   265                                                      
REMARK 465     ARG F   266                                                      
REMARK 465     SER F   267                                                      
REMARK 465     LEU F   268                                                      
REMARK 465     LEU F   269                                                      
REMARK 465     GLY F   270                                                      
REMARK 465     GLY F   271                                                      
REMARK 465     PRO F   272                                                      
REMARK 465     ALA F   273                                                      
REMARK 465     ALA F   274                                                      
REMARK 465     LEU F   275                                                      
REMARK 465     SER F   276                                                      
REMARK 465     PRO F   277                                                      
REMARK 465     LEU F   278                                                      
REMARK 465     THR F   279                                                      
REMARK 465     PRO F   280                                                      
REMARK 465     SER F   281                                                      
REMARK 465     PHE F   282                                                      
REMARK 465     GLY F   283                                                      
REMARK 465     ILE F   284                                                      
REMARK 465     LEU F   285                                                      
REMARK 465     PRO F   286                                                      
REMARK 465     LEU F   287                                                      
REMARK 465     GLU F   288                                                      
REMARK 465     THR F   289                                                      
REMARK 465     PRO F   290                                                      
REMARK 465     SER F   291                                                      
REMARK 465     PRO F   292                                                      
REMARK 465     GLY F   293                                                      
REMARK 465     ASP F   294                                                      
REMARK 465     GLY F   295                                                      
REMARK 465     SER F   296                                                      
REMARK 465     TYR F   297                                                      
REMARK 465     LEU F   298                                                      
REMARK 465     GLN F   299                                                      
REMARK 465     ASN F   300                                                      
REMARK 465     TYR F   301                                                      
REMARK 465     THR F   302                                                      
REMARK 465     ASN F   303                                                      
REMARK 465     THR F   304                                                      
REMARK 465     PRO F   305                                                      
REMARK 465     PRO F   306                                                      
REMARK 465     VAL F   307                                                      
REMARK 465     ILE F   308                                                      
REMARK 465     ASP F   309                                                      
REMARK 465     VAL F   310                                                      
REMARK 465     PRO F   311                                                      
REMARK 465     SER F   312                                                      
REMARK 465     THR F   313                                                      
REMARK 465     GLY F   314                                                      
REMARK 465     ALA F   315                                                      
REMARK 465     PRO F   316                                                      
REMARK 465     SER F   317                                                      
REMARK 465     LYS F   318                                                      
REMARK 465     LYS F   319                                                      
REMARK 465     SER F   320                                                      
REMARK 465     VAL F   321                                                      
REMARK 465     ALA F   322                                                      
REMARK 465     ARG F   323                                                      
REMARK 465     ILE F   324                                                      
REMARK 465     GLY F   325                                                      
REMARK 465     GLN F   326                                                      
REMARK 465     THR F   327                                                      
REMARK 465     GLY F   328                                                      
REMARK 465     THR F   329                                                      
REMARK 465     LYS F   330                                                      
REMARK 465     SER F   331                                                      
REMARK 465     VAL F   332                                                      
REMARK 465     PHE F   333                                                      
REMARK 465     SER F   334                                                      
REMARK 465     GLN F   335                                                      
REMARK 465     SER F   336                                                      
REMARK 465     GLY F   337                                                      
REMARK 465     ASN F   338                                                      
REMARK 465     SER F   339                                                      
REMARK 465     ARG F   340                                                      
REMARK 465     GLU F   341                                                      
REMARK 465     VAL F   342                                                      
REMARK 465     THR F   343                                                      
REMARK 465     PRO F   344                                                      
REMARK 465     ILE F   345                                                      
REMARK 465     LEU F   346                                                      
REMARK 465     ALA F   347                                                      
REMARK 465     GLN F   348                                                      
REMARK 465     THR F   349                                                      
REMARK 465     GLN F   350                                                      
REMARK 465     SER F   351                                                      
REMARK 465     SER F   352                                                      
REMARK 465     GLY F   353                                                      
REMARK 465     PRO F   354                                                      
REMARK 465     GLN F   355                                                      
REMARK 465     THR F   356                                                      
REMARK 465     SER F   357                                                      
REMARK 465     THR F   358                                                      
REMARK 465     THR F   359                                                      
REMARK 465     PRO F   360                                                      
REMARK 465     GLN F   361                                                      
REMARK 465     VAL F   362                                                      
REMARK 465     LEU F   363                                                      
REMARK 465     SER F   364                                                      
REMARK 465     PRO F   365                                                      
REMARK 465     THR F   366                                                      
REMARK 465     ILE F   367                                                      
REMARK 465     THR F   368                                                      
REMARK 465     SER F   369                                                      
REMARK 465     PRO F   370                                                      
REMARK 465     PRO F   371                                                      
REMARK 465     ASN F   372                                                      
REMARK 465     ALA F   373                                                      
REMARK 465     LEU F   374                                                      
REMARK 465     PRO F   375                                                      
REMARK 465     ARG F   376                                                      
REMARK 465     ARG F   377                                                      
REMARK 465     SER F   378                                                      
REMARK 465     SER F   379                                                      
REMARK 465     ARG F   380                                                      
REMARK 465     LEU F   381                                                      
REMARK 465     PHE F   382                                                      
REMARK 465     THR F   383                                                      
REMARK 465     SER F   384                                                      
REMARK 465     ASP F   385                                                      
REMARK 465     SER F   386                                                      
REMARK 465     SER F   387                                                      
REMARK 465     THR F   388                                                      
REMARK 465     THR F   389                                                      
REMARK 465     LYS F   390                                                      
REMARK 465     GLU F   391                                                      
REMARK 465     ASN F   392                                                      
REMARK 465     SER F   393                                                      
REMARK 465     LYS F   394                                                      
REMARK 465     LYS F   395                                                      
REMARK 465     LEU F   396                                                      
REMARK 465     LYS F   397                                                      
REMARK 465     MET F   398                                                      
REMARK 465     LYS F   399                                                      
REMARK 465     PHE F   400                                                      
REMARK 465     PRO F   401                                                      
REMARK 465     PRO F   402                                                      
REMARK 465     LYS F   403                                                      
REMARK 465     ILE F   404                                                      
REMARK 465     PRO F   405                                                      
REMARK 465     ASN F   406                                                      
REMARK 465     ARG F   407                                                      
REMARK 465     LYS F   408                                                      
REMARK 465     THR F   409                                                      
REMARK 465     LYS F   410                                                      
REMARK 465     SER F   411                                                      
REMARK 465     LYS F   412                                                      
REMARK 465     THR F   413                                                      
REMARK 465     ASN F   414                                                      
REMARK 465     LYS F   415                                                      
REMARK 465     GLY F   416                                                      
REMARK 465     GLY F   417                                                      
REMARK 465     ILE F   418                                                      
REMARK 465     THR F   419                                                      
REMARK 465     GLN F   420                                                      
REMARK 465     PRO F   421                                                      
REMARK 465     ASN F   422                                                      
REMARK 465     ILE F   423                                                      
REMARK 465     ASN F   424                                                      
REMARK 465     ASP F   425                                                      
REMARK 465     SER F   426                                                      
REMARK 465     LEU F   427                                                      
REMARK 465     GLU F   428                                                      
REMARK 465     ILE F   429                                                      
REMARK 465     THR F   430                                                      
REMARK 465     LYS F   431                                                      
REMARK 465     LEU F   432                                                      
REMARK 465     ASP F   433                                                      
REMARK 465     SER F   434                                                      
REMARK 465     SER F   435                                                      
REMARK 465     ILE F   436                                                      
REMARK 465     ILE F   437                                                      
REMARK 465     SER F   438                                                      
REMARK 465     GLU F   439                                                      
REMARK 465     GLY F   440                                                      
REMARK 465     LYS F   441                                                      
REMARK 465     ILE F   442                                                      
REMARK 465     SER F   443                                                      
REMARK 465     THR F   444                                                      
REMARK 465     ILE F   445                                                      
REMARK 465     THR F   446                                                      
REMARK 465     PRO F   447                                                      
REMARK 465     GLN F   448                                                      
REMARK 465     ILE F   449                                                      
REMARK 465     GLN F   450                                                      
REMARK 465     ALA F   451                                                      
REMARK 465     PHE F   452                                                      
REMARK 465     ASN F   453                                                      
REMARK 465     LEU F   454                                                      
REMARK 465     LYS F   683                                                      
REMARK 465     LYS F   684                                                      
REMARK 465     SER F   685                                                      
REMARK 465     GLU F   686                                                      
REMARK 465     LYS F   687                                                      
REMARK 465     ALA F   688                                                      
REMARK 465     LEU F   689                                                      
REMARK 465     ASP F   690                                                      
REMARK 465     ALA F   756                                                      
REMARK 465     LEU F   757                                                      
REMARK 465     MET F   758                                                      
REMARK 465     ASN F   759                                                      
REMARK 465     PHE F   760                                                      
REMARK 465     SER F   761                                                      
REMARK 465     TRP F   762                                                      
REMARK 465     ALA F   763                                                      
REMARK 465     MET F   764                                                      
REMARK 465     ASP F   765                                                      
REMARK 465     LEU F   766                                                      
REMARK 465     ASP F   767                                                      
REMARK 465     PRO F   768                                                      
REMARK 465     LYS F   769                                                      
REMARK 465     GLY F   770                                                      
REMARK 465     ALA F   771                                                      
REMARK 465     ASN F   772                                                      
REMARK 465     ASN F   773                                                      
REMARK 465     GLN F   774                                                      
REMARK 465     ILE F   775                                                      
REMARK 465     LYS F   776                                                      
REMARK 465     GLU F   777                                                      
REMARK 465     ALA F   778                                                      
REMARK 465     ILE F   779                                                      
REMARK 465     ASP F   780                                                      
REMARK 465     LYS F   781                                                      
REMARK 465     ARG F   782                                                      
REMARK 465     TYR F   783                                                      
REMARK 465     LEU F   784                                                      
REMARK 465     PRO F   785                                                      
REMARK 465     ASP F   786                                                      
REMARK 465     ASP F   787                                                      
REMARK 465     GLU F   788                                                      
REMARK 465     GLU F   789                                                      
REMARK 465     PRO F   790                                                      
REMARK 465     ILE F   791                                                      
REMARK 465     THR F   792                                                      
REMARK 465     GLN F   793                                                      
REMARK 465     GLU F   794                                                      
REMARK 465     GLU F   795                                                      
REMARK 465     GLN F   796                                                      
REMARK 465     ILE F   797                                                      
REMARK 465     MET F   798                                                      
REMARK 465     GLY F   799                                                      
REMARK 465     THR F   800                                                      
REMARK 465     ASP F   801                                                      
REMARK 465     GLU F   802                                                      
REMARK 465     SER F   803                                                      
REMARK 465     GLN F   804                                                      
REMARK 465     GLU F   805                                                      
REMARK 465     SER F   806                                                      
REMARK 465     SER F   807                                                      
REMARK 465     MET F   808                                                      
REMARK 465     THR F   809                                                      
REMARK 465     ASP F   810                                                      
REMARK 465     ALA F   811                                                      
REMARK 465     ASP F   812                                                      
REMARK 465     ASP F   813                                                      
REMARK 465     THR F   814                                                      
REMARK 465     GLN F   815                                                      
REMARK 465     LEU F   816                                                      
REMARK 465     HIS F   817                                                      
REMARK 465     ALA F   818                                                      
REMARK 465     ALA F   819                                                      
REMARK 465     GLU F   820                                                      
REMARK 465     SER F   821                                                      
REMARK 465     ASP F   822                                                      
REMARK 465     GLU F   823                                                      
REMARK 465     PHE F   824                                                      
REMARK 465     LEU G    26                                                      
REMARK 465     GLU G    27                                                      
REMARK 465     THR G    28                                                      
REMARK 465     ARG G    29                                                      
REMARK 465     LYS G    30                                                      
REMARK 465     LYS G    31                                                      
REMARK 465     GLN G    32                                                      
REMARK 465     LYS G    33                                                      
REMARK 465     GLU G    34                                                      
REMARK 465     ASP G    35                                                      
REMARK 465     VAL G    36                                                      
REMARK 465     GLU G    37                                                      
REMARK 465     VAL G    38                                                      
REMARK 465     VAL G    39                                                      
REMARK 465     GLY G    40                                                      
REMARK 465     GLY G    41                                                      
REMARK 465     SER G    42                                                      
REMARK 465     ASP G    43                                                      
REMARK 465     GLY G    44                                                      
REMARK 465     GLU G    45                                                      
REMARK 465     GLY G    46                                                      
REMARK 465     ALA G    47                                                      
REMARK 465     ILE G    48                                                      
REMARK 465     GLY G    49                                                      
REMARK 465     LEU G    50                                                      
REMARK 465     SER G    51                                                      
REMARK 465     SER G    52                                                      
REMARK 465     ASP G    53                                                      
REMARK 465     PRO G    54                                                      
REMARK 465     LYS G    55                                                      
REMARK 465     SER G    56                                                      
REMARK 465     ARG G    57                                                      
REMARK 465     GLU G    58                                                      
REMARK 465     GLN G    59                                                      
REMARK 465     MET G    60                                                      
REMARK 465     ILE G    61                                                      
REMARK 465     ASN G    62                                                      
REMARK 465     ASP G    63                                                      
REMARK 465     ARG G    64                                                      
REMARK 465     ILE G    65                                                      
REMARK 465     GLY G    66                                                      
REMARK 465     TYR G    67                                                      
REMARK 465     LYS G    68                                                      
REMARK 465     PRO G    69                                                      
REMARK 465     GLN G    70                                                      
REMARK 465     PRO G    71                                                      
REMARK 465     LYS G    72                                                      
REMARK 465     PRO G    73                                                      
REMARK 465     ASN G    74                                                      
REMARK 465     ASN G    75                                                      
REMARK 465     ARG G    76                                                      
REMARK 465     SER G    77                                                      
REMARK 465     SER G    78                                                      
REMARK 465     GLN G    79                                                      
REMARK 465     PHE G    80                                                      
REMARK 465     GLY G    81                                                      
REMARK 465     SER G    82                                                      
REMARK 465     LEU G    83                                                      
REMARK 465     GLU G    84                                                      
REMARK 465     PHE G    85                                                      
REMARK 465     MET H     1                                                      
REMARK 465     THR H     2                                                      
REMARK 465     VAL H     3                                                      
REMARK 465     LEU H     4                                                      
REMARK 465     PHE H   176                                                      
REMARK 465     SER H   177                                                      
REMARK 465     ASN H   178                                                      
REMARK 465     CYS H   179                                                      
REMARK 465     LEU H   180                                                      
REMARK 465     PRO H   181                                                      
REMARK 465     ASN H   182                                                      
REMARK 465     SER H   183                                                      
REMARK 465     CYS H   184                                                      
REMARK 465     THR H   185                                                      
REMARK 465     THR H   186                                                      
REMARK 465     GLN H   187                                                      
REMARK 465     VAL H   188                                                      
REMARK 465     PRO H   189                                                      
REMARK 465     ASN H   190                                                      
REMARK 465     HIS H   191                                                      
REMARK 465     SER H   192                                                      
REMARK 465     LEU H   193                                                      
REMARK 465     SER H   194                                                      
REMARK 465     HIS H   195                                                      
REMARK 465     ARG H   196                                                      
REMARK 465     GLN H   197                                                      
REMARK 465     PRO H   198                                                      
REMARK 465     GLU H   199                                                      
REMARK 465     THR H   200                                                      
REMARK 465     VAL H   201                                                      
REMARK 465     LEU H   202                                                      
REMARK 465     THR H   203                                                      
REMARK 465     GLU H   204                                                      
REMARK 465     THR H   205                                                      
REMARK 465     PRO H   206                                                      
REMARK 465     GLN H   207                                                      
REMARK 465     ASP H   208                                                      
REMARK 465     THR H   209                                                      
REMARK 465     ILE H   210                                                      
REMARK 465     GLU H   211                                                      
REMARK 465     LEU H   212                                                      
REMARK 465     ASN H   213                                                      
REMARK 465     ARG H   214                                                      
REMARK 465     LEU H   215                                                      
REMARK 465     ASN H   216                                                      
REMARK 465     LEU H   217                                                      
REMARK 465     GLU H   218                                                      
REMARK 465     SER H   219                                                      
REMARK 465     SER H   220                                                      
REMARK 465     ASN H   221                                                      
REMARK 465     SER H   222                                                      
REMARK 465     LYS H   223                                                      
REMARK 465     TYR H   224                                                      
REMARK 465     SER H   225                                                      
REMARK 465     LEU H   226                                                      
REMARK 465     ASN H   227                                                      
REMARK 465     THR H   228                                                      
REMARK 465     ASP H   229                                                      
REMARK 465     SER H   230                                                      
REMARK 465     SER H   231                                                      
REMARK 465     VAL H   232                                                      
REMARK 465     SER H   233                                                      
REMARK 465     TYR H   234                                                      
REMARK 465     ILE H   235                                                      
REMARK 465     ASP H   236                                                      
REMARK 465     SER H   237                                                      
REMARK 465     ALA H   238                                                      
REMARK 465     VAL H   239                                                      
REMARK 465     ILE H   240                                                      
REMARK 465     SER H   241                                                      
REMARK 465     PRO H   242                                                      
REMARK 465     ASP H   243                                                      
REMARK 465     THR H   244                                                      
REMARK 465     VAL H   245                                                      
REMARK 465     PRO H   246                                                      
REMARK 465     LEU H   247                                                      
REMARK 465     GLY H   248                                                      
REMARK 465     THR H   249                                                      
REMARK 465     GLY H   250                                                      
REMARK 465     THR H   251                                                      
REMARK 465     SER H   252                                                      
REMARK 465     ILE H   253                                                      
REMARK 465     LEU H   254                                                      
REMARK 465     SER H   255                                                      
REMARK 465     LYS H   256                                                      
REMARK 465     GLN H   257                                                      
REMARK 465     VAL H   258                                                      
REMARK 465     GLN H   259                                                      
REMARK 465     ASN H   260                                                      
REMARK 465     LYS H   261                                                      
REMARK 465     PRO H   262                                                      
REMARK 465     LYS H   263                                                      
REMARK 465     THR H   264                                                      
REMARK 465     GLY H   265                                                      
REMARK 465     ARG H   266                                                      
REMARK 465     SER H   267                                                      
REMARK 465     LEU H   268                                                      
REMARK 465     LEU H   269                                                      
REMARK 465     GLY H   270                                                      
REMARK 465     GLY H   271                                                      
REMARK 465     PRO H   272                                                      
REMARK 465     ALA H   273                                                      
REMARK 465     ALA H   274                                                      
REMARK 465     LEU H   275                                                      
REMARK 465     SER H   276                                                      
REMARK 465     PRO H   277                                                      
REMARK 465     LEU H   278                                                      
REMARK 465     THR H   279                                                      
REMARK 465     PRO H   280                                                      
REMARK 465     SER H   281                                                      
REMARK 465     PHE H   282                                                      
REMARK 465     GLY H   283                                                      
REMARK 465     ILE H   284                                                      
REMARK 465     LEU H   285                                                      
REMARK 465     PRO H   286                                                      
REMARK 465     LEU H   287                                                      
REMARK 465     GLU H   288                                                      
REMARK 465     THR H   289                                                      
REMARK 465     PRO H   290                                                      
REMARK 465     SER H   291                                                      
REMARK 465     PRO H   292                                                      
REMARK 465     GLY H   293                                                      
REMARK 465     ASP H   294                                                      
REMARK 465     GLY H   295                                                      
REMARK 465     SER H   296                                                      
REMARK 465     TYR H   297                                                      
REMARK 465     LEU H   298                                                      
REMARK 465     GLN H   299                                                      
REMARK 465     ASN H   300                                                      
REMARK 465     TYR H   301                                                      
REMARK 465     THR H   302                                                      
REMARK 465     ASN H   303                                                      
REMARK 465     THR H   304                                                      
REMARK 465     PRO H   305                                                      
REMARK 465     PRO H   306                                                      
REMARK 465     VAL H   307                                                      
REMARK 465     ILE H   308                                                      
REMARK 465     ASP H   309                                                      
REMARK 465     VAL H   310                                                      
REMARK 465     PRO H   311                                                      
REMARK 465     SER H   312                                                      
REMARK 465     THR H   313                                                      
REMARK 465     GLY H   314                                                      
REMARK 465     ALA H   315                                                      
REMARK 465     PRO H   316                                                      
REMARK 465     SER H   317                                                      
REMARK 465     LYS H   318                                                      
REMARK 465     LYS H   319                                                      
REMARK 465     SER H   320                                                      
REMARK 465     VAL H   321                                                      
REMARK 465     ALA H   322                                                      
REMARK 465     ARG H   323                                                      
REMARK 465     ILE H   324                                                      
REMARK 465     GLY H   325                                                      
REMARK 465     GLN H   326                                                      
REMARK 465     THR H   327                                                      
REMARK 465     GLY H   328                                                      
REMARK 465     THR H   329                                                      
REMARK 465     LYS H   330                                                      
REMARK 465     SER H   331                                                      
REMARK 465     VAL H   332                                                      
REMARK 465     PHE H   333                                                      
REMARK 465     SER H   334                                                      
REMARK 465     GLN H   335                                                      
REMARK 465     SER H   336                                                      
REMARK 465     GLY H   337                                                      
REMARK 465     ASN H   338                                                      
REMARK 465     SER H   339                                                      
REMARK 465     ARG H   340                                                      
REMARK 465     GLU H   341                                                      
REMARK 465     VAL H   342                                                      
REMARK 465     THR H   343                                                      
REMARK 465     PRO H   344                                                      
REMARK 465     ILE H   345                                                      
REMARK 465     LEU H   346                                                      
REMARK 465     ALA H   347                                                      
REMARK 465     GLN H   348                                                      
REMARK 465     THR H   349                                                      
REMARK 465     GLN H   350                                                      
REMARK 465     SER H   351                                                      
REMARK 465     SER H   352                                                      
REMARK 465     GLY H   353                                                      
REMARK 465     PRO H   354                                                      
REMARK 465     GLN H   355                                                      
REMARK 465     THR H   356                                                      
REMARK 465     SER H   357                                                      
REMARK 465     THR H   358                                                      
REMARK 465     THR H   359                                                      
REMARK 465     PRO H   360                                                      
REMARK 465     GLN H   361                                                      
REMARK 465     VAL H   362                                                      
REMARK 465     LEU H   363                                                      
REMARK 465     SER H   364                                                      
REMARK 465     PRO H   365                                                      
REMARK 465     THR H   366                                                      
REMARK 465     ILE H   367                                                      
REMARK 465     THR H   368                                                      
REMARK 465     SER H   369                                                      
REMARK 465     PRO H   370                                                      
REMARK 465     PRO H   371                                                      
REMARK 465     ASN H   372                                                      
REMARK 465     ALA H   373                                                      
REMARK 465     LEU H   374                                                      
REMARK 465     PRO H   375                                                      
REMARK 465     ARG H   376                                                      
REMARK 465     ARG H   377                                                      
REMARK 465     SER H   378                                                      
REMARK 465     SER H   379                                                      
REMARK 465     ARG H   380                                                      
REMARK 465     LEU H   381                                                      
REMARK 465     PHE H   382                                                      
REMARK 465     THR H   383                                                      
REMARK 465     SER H   384                                                      
REMARK 465     ASP H   385                                                      
REMARK 465     SER H   386                                                      
REMARK 465     SER H   387                                                      
REMARK 465     THR H   388                                                      
REMARK 465     THR H   389                                                      
REMARK 465     LYS H   390                                                      
REMARK 465     GLU H   391                                                      
REMARK 465     ASN H   392                                                      
REMARK 465     SER H   393                                                      
REMARK 465     LYS H   394                                                      
REMARK 465     LYS H   395                                                      
REMARK 465     LEU H   396                                                      
REMARK 465     LYS H   397                                                      
REMARK 465     MET H   398                                                      
REMARK 465     LYS H   399                                                      
REMARK 465     PHE H   400                                                      
REMARK 465     PRO H   401                                                      
REMARK 465     PRO H   402                                                      
REMARK 465     LYS H   403                                                      
REMARK 465     ILE H   404                                                      
REMARK 465     PRO H   405                                                      
REMARK 465     ASN H   406                                                      
REMARK 465     ARG H   407                                                      
REMARK 465     LYS H   408                                                      
REMARK 465     THR H   409                                                      
REMARK 465     LYS H   410                                                      
REMARK 465     SER H   411                                                      
REMARK 465     LYS H   412                                                      
REMARK 465     THR H   413                                                      
REMARK 465     ASN H   414                                                      
REMARK 465     LYS H   415                                                      
REMARK 465     GLY H   416                                                      
REMARK 465     GLY H   417                                                      
REMARK 465     ILE H   418                                                      
REMARK 465     THR H   419                                                      
REMARK 465     GLN H   420                                                      
REMARK 465     PRO H   421                                                      
REMARK 465     ASN H   422                                                      
REMARK 465     ILE H   423                                                      
REMARK 465     ASN H   424                                                      
REMARK 465     ASP H   425                                                      
REMARK 465     SER H   426                                                      
REMARK 465     LEU H   427                                                      
REMARK 465     GLU H   428                                                      
REMARK 465     ILE H   429                                                      
REMARK 465     THR H   430                                                      
REMARK 465     LYS H   431                                                      
REMARK 465     LEU H   432                                                      
REMARK 465     ASP H   433                                                      
REMARK 465     SER H   434                                                      
REMARK 465     SER H   435                                                      
REMARK 465     ILE H   436                                                      
REMARK 465     ILE H   437                                                      
REMARK 465     SER H   438                                                      
REMARK 465     GLU H   439                                                      
REMARK 465     GLY H   440                                                      
REMARK 465     LYS H   441                                                      
REMARK 465     ILE H   442                                                      
REMARK 465     SER H   443                                                      
REMARK 465     THR H   444                                                      
REMARK 465     ILE H   445                                                      
REMARK 465     THR H   446                                                      
REMARK 465     PRO H   447                                                      
REMARK 465     GLN H   448                                                      
REMARK 465     ILE H   449                                                      
REMARK 465     GLN H   450                                                      
REMARK 465     PRO H   768                                                      
REMARK 465     LYS H   769                                                      
REMARK 465     GLY H   770                                                      
REMARK 465     ALA H   771                                                      
REMARK 465     ASN H   772                                                      
REMARK 465     ASN H   773                                                      
REMARK 465     GLN H   774                                                      
REMARK 465     ILE H   775                                                      
REMARK 465     LYS H   776                                                      
REMARK 465     GLU H   777                                                      
REMARK 465     ALA H   778                                                      
REMARK 465     ILE H   779                                                      
REMARK 465     ASP H   780                                                      
REMARK 465     LYS H   781                                                      
REMARK 465     ARG H   782                                                      
REMARK 465     TYR H   783                                                      
REMARK 465     LEU H   784                                                      
REMARK 465     PRO H   785                                                      
REMARK 465     ASP H   786                                                      
REMARK 465     ASP H   787                                                      
REMARK 465     GLU H   788                                                      
REMARK 465     GLU H   789                                                      
REMARK 465     PRO H   790                                                      
REMARK 465     ILE H   791                                                      
REMARK 465     THR H   792                                                      
REMARK 465     GLN H   793                                                      
REMARK 465     GLU H   794                                                      
REMARK 465     GLU H   795                                                      
REMARK 465     GLN H   796                                                      
REMARK 465     ILE H   797                                                      
REMARK 465     MET H   798                                                      
REMARK 465     GLY H   799                                                      
REMARK 465     THR H   800                                                      
REMARK 465     ASP H   801                                                      
REMARK 465     GLU H   802                                                      
REMARK 465     SER H   803                                                      
REMARK 465     GLN H   804                                                      
REMARK 465     GLU H   805                                                      
REMARK 465     SER H   806                                                      
REMARK 465     SER H   807                                                      
REMARK 465     MET H   808                                                      
REMARK 465     THR H   809                                                      
REMARK 465     ASP H   810                                                      
REMARK 465     ALA H   811                                                      
REMARK 465     ASP H   812                                                      
REMARK 465     ASP H   813                                                      
REMARK 465     THR H   814                                                      
REMARK 465     GLN H   815                                                      
REMARK 465     LEU H   816                                                      
REMARK 465     HIS H   817                                                      
REMARK 465     ALA H   818                                                      
REMARK 465     ALA H   819                                                      
REMARK 465     GLU H   820                                                      
REMARK 465     SER H   821                                                      
REMARK 465     ASP H   822                                                      
REMARK 465     GLU H   823                                                      
REMARK 465     PHE H   824                                                      
REMARK 465     MET I     1                                                      
REMARK 465     LEU I     2                                                      
REMARK 465     ARG I     3                                                      
REMARK 465     PHE I     4                                                      
REMARK 465     PRO I     5                                                      
REMARK 465     LEU I   434                                                      
REMARK 465     GLU I   458                                                      
REMARK 465     ALA I   459                                                      
REMARK 465     PRO I   460                                                      
REMARK 465     ASP I   461                                                      
REMARK 465     LEU I   462                                                      
REMARK 465     TYR I   463                                                      
REMARK 465     ASN I   464                                                      
REMARK 465     ARG I   465                                                      
REMARK 465     LYS I   466                                                      
REMARK 465     GLY I   467                                                      
REMARK 465     LYS I   468                                                      
REMARK 465     TYR I   469                                                      
REMARK 465     PHE I   470                                                      
REMARK 465     ASN I   471                                                      
REMARK 465     VAL I   472                                                      
REMARK 465     SER I   758                                                      
REMARK 465     ASP I   759                                                      
REMARK 465     GLU I   760                                                      
REMARK 465     GLU I   761                                                      
REMARK 465     GLU I   762                                                      
REMARK 465     GLU I   763                                                      
REMARK 465     ALA I   764                                                      
REMARK 465     SER I   765                                                      
REMARK 465     ASN I   766                                                      
REMARK 465     LYS I   767                                                      
REMARK 465     PRO I   768                                                      
REMARK 465     VAL I   769                                                      
REMARK 465     LYS I   770                                                      
REMARK 465     ILE I   771                                                      
REMARK 465     LYS I   772                                                      
REMARK 465     GLU I   773                                                      
REMARK 465     GLU I   774                                                      
REMARK 465     VAL I   775                                                      
REMARK 465     LEU I   776                                                      
REMARK 465     SER I   777                                                      
REMARK 465     GLU I   778                                                      
REMARK 465     SER I   779                                                      
REMARK 465     GLU I   780                                                      
REMARK 465     ALA I   781                                                      
REMARK 465     GLU I   782                                                      
REMARK 465     ASN I   783                                                      
REMARK 465     GLN I   784                                                      
REMARK 465     GLN I   785                                                      
REMARK 465     ALA I   786                                                      
REMARK 465     GLY I   787                                                      
REMARK 465     ALA I   788                                                      
REMARK 465     ALA I   789                                                      
REMARK 465     ALA I   790                                                      
REMARK 465     LEU I   791                                                      
REMARK 465     ALA I   792                                                      
REMARK 465     PRO I   793                                                      
REMARK 465     GLU I   794                                                      
REMARK 465     ILE I   795                                                      
REMARK 465     VAL I   796                                                      
REMARK 465     ILE I   797                                                      
REMARK 465     LYS I   798                                                      
REMARK 465     VAL I   799                                                      
REMARK 465     GLU I   800                                                      
REMARK 465     LYS I   801                                                      
REMARK 465     LEU I   802                                                      
REMARK 465     ASP I   803                                                      
REMARK 465     PRO I   804                                                      
REMARK 465     GLU I   805                                                      
REMARK 465     LEU I   806                                                      
REMARK 465     ASP I   807                                                      
REMARK 465     SER I   808                                                      
REMARK 465     MET J     1                                                      
REMARK 465     GLU J    96                                                      
REMARK 465     GLU J    97                                                      
REMARK 465     PRO J    98                                                      
REMARK 465     ILE J    99                                                      
REMARK 465     ASN J   100                                                      
REMARK 465     LYS J   101                                                      
REMARK 465     ARG J   102                                                      
REMARK 465     LEU J   103                                                      
REMARK 465     PHE J   104                                                      
REMARK 465     GLU J   105                                                      
REMARK 465     LYS J   106                                                      
REMARK 465     TYR J   107                                                      
REMARK 465     LEU J   108                                                      
REMARK 465     LYS J   109                                                      
REMARK 465     ASP J   110                                                      
REMARK 465     GLU J   111                                                      
REMARK 465     SER J   112                                                      
REMARK 465     GLY J   113                                                      
REMARK 465     PHE J   114                                                      
REMARK 465     LYS J   115                                                      
REMARK 465     ASP J   116                                                      
REMARK 465     PRO J   117                                                      
REMARK 465     SER J   118                                                      
REMARK 465     SER J   119                                                      
REMARK 465     ASP J   120                                                      
REMARK 465     TRP J   121                                                      
REMARK 465     GLU J   122                                                      
REMARK 465     MET J   123                                                      
REMARK 465     ILE J   534                                                      
REMARK 465     GLY J   535                                                      
REMARK 465     ALA J   536                                                      
REMARK 465     ASP J   537                                                      
REMARK 465     ILE J   538                                                      
REMARK 465     LYS J   539                                                      
REMARK 465     ASP J   540                                                      
REMARK 465     LYS J   541                                                      
REMARK 465     LEU J   542                                                      
REMARK 465     LYS J   543                                                      
REMARK 465     CYS J   544                                                      
REMARK 465     TYR J   545                                                      
REMARK 465     ASP J   546                                                      
REMARK 465     PHE J   547                                                      
REMARK 465     ASP J   548                                                      
REMARK 465     VAL J   549                                                      
REMARK 465     HIS J   550                                                      
REMARK 465     THR J   551                                                      
REMARK 465     MET J   552                                                      
REMARK 465     LYS J   553                                                      
REMARK 465     THR J   554                                                      
REMARK 465     LEU J   555                                                      
REMARK 465     LYS J   556                                                      
REMARK 465     ASN J   557                                                      
REMARK 465     ILE J   558                                                      
REMARK 465     ILE J   559                                                      
REMARK 465     SER J   560                                                      
REMARK 465     PRO J   561                                                      
REMARK 465     PRO J   562                                                      
REMARK 465     TRP J   563                                                      
REMARK 465     ASP J   564                                                      
REMARK 465     PHE J   565                                                      
REMARK 465     ARG J   566                                                      
REMARK 465     GLU J   567                                                      
REMARK 465     PHE J   568                                                      
REMARK 465     GLU J   569                                                      
REMARK 465     VAL J   570                                                      
REMARK 465     GLU J   571                                                      
REMARK 465     LYS J   572                                                      
REMARK 465     GLN J   573                                                      
REMARK 465     THR J   574                                                      
REMARK 465     ALA J   575                                                      
REMARK 465     GLU J   576                                                      
REMARK 465     GLU J   577                                                      
REMARK 465     THR J   578                                                      
REMARK 465     GLY J   579                                                      
REMARK 465     LEU J   580                                                      
REMARK 465     THR J   581                                                      
REMARK 465     PRO J   582                                                      
REMARK 465     LEU J   583                                                      
REMARK 465     GLU J   584                                                      
REMARK 465     THR J   585                                                      
REMARK 465     SER J   586                                                      
REMARK 465     ARG J   587                                                      
REMARK 465     LYS J   588                                                      
REMARK 465     THR J   589                                                      
REMARK 465     PRO J   590                                                      
REMARK 465     ASP J   591                                                      
REMARK 465     SER J   592                                                      
REMARK 465     ARG J   593                                                      
REMARK 465     PRO J   594                                                      
REMARK 465     SER J   595                                                      
REMARK 465     LEU J   596                                                      
REMARK 465     GLU J   597                                                      
REMARK 465     GLU J   598                                                      
REMARK 465     THR J   599                                                      
REMARK 465     PHE J   600                                                      
REMARK 465     GLU J   601                                                      
REMARK 465     ILE J   602                                                      
REMARK 465     GLU J   603                                                      
REMARK 465     MET J   604                                                      
REMARK 465     ASN J   605                                                      
REMARK 465     GLU J   606                                                      
REMARK 465     SER J   607                                                      
REMARK 465     ASP J   608                                                      
REMARK 465     MET J   609                                                      
REMARK 465     MET J   610                                                      
REMARK 465     LEU J   611                                                      
REMARK 465     GLU J   612                                                      
REMARK 465     THR J   613                                                      
REMARK 465     SER J   614                                                      
REMARK 465     MET J   615                                                      
REMARK 465     SER J   616                                                      
REMARK 465     ASP J   617                                                      
REMARK 465     HIS J   618                                                      
REMARK 465     SER J   619                                                      
REMARK 465     THR J   620                                                      
REMARK 465     MET K     1                                                      
REMARK 465     ASP K    94                                                      
REMARK 465     MET K    95                                                      
REMARK 465     GLU K    96                                                      
REMARK 465     GLU K    97                                                      
REMARK 465     PRO K    98                                                      
REMARK 465     ILE K    99                                                      
REMARK 465     ASN K   100                                                      
REMARK 465     LYS K   101                                                      
REMARK 465     ARG K   102                                                      
REMARK 465     LEU K   103                                                      
REMARK 465     PHE K   104                                                      
REMARK 465     GLU K   105                                                      
REMARK 465     LYS K   106                                                      
REMARK 465     TYR K   107                                                      
REMARK 465     LEU K   108                                                      
REMARK 465     LYS K   109                                                      
REMARK 465     ASP K   110                                                      
REMARK 465     GLU K   111                                                      
REMARK 465     SER K   112                                                      
REMARK 465     GLY K   113                                                      
REMARK 465     PHE K   114                                                      
REMARK 465     LYS K   115                                                      
REMARK 465     ASP K   116                                                      
REMARK 465     PRO K   117                                                      
REMARK 465     SER K   118                                                      
REMARK 465     SER K   119                                                      
REMARK 465     ASP K   120                                                      
REMARK 465     TRP K   121                                                      
REMARK 465     GLU K   122                                                      
REMARK 465     MET K   123                                                      
REMARK 465     SER K   124                                                      
REMARK 465     GLN K   125                                                      
REMARK 465     SER K   126                                                      
REMARK 465     GLY K   528                                                      
REMARK 465     ASP K   529                                                      
REMARK 465     SER K   530                                                      
REMARK 465     GLU K   531                                                      
REMARK 465     ALA K   532                                                      
REMARK 465     TYR K   533                                                      
REMARK 465     ILE K   534                                                      
REMARK 465     GLY K   535                                                      
REMARK 465     ALA K   536                                                      
REMARK 465     ASP K   537                                                      
REMARK 465     ILE K   538                                                      
REMARK 465     LYS K   539                                                      
REMARK 465     ASP K   540                                                      
REMARK 465     LYS K   541                                                      
REMARK 465     LEU K   542                                                      
REMARK 465     LYS K   543                                                      
REMARK 465     CYS K   544                                                      
REMARK 465     TYR K   545                                                      
REMARK 465     ASP K   546                                                      
REMARK 465     PHE K   547                                                      
REMARK 465     ASP K   548                                                      
REMARK 465     VAL K   549                                                      
REMARK 465     HIS K   550                                                      
REMARK 465     THR K   551                                                      
REMARK 465     MET K   552                                                      
REMARK 465     LYS K   553                                                      
REMARK 465     THR K   554                                                      
REMARK 465     LEU K   555                                                      
REMARK 465     LYS K   556                                                      
REMARK 465     ASN K   557                                                      
REMARK 465     ILE K   558                                                      
REMARK 465     ILE K   559                                                      
REMARK 465     SER K   560                                                      
REMARK 465     PRO K   561                                                      
REMARK 465     PRO K   562                                                      
REMARK 465     TRP K   563                                                      
REMARK 465     ASP K   564                                                      
REMARK 465     PHE K   565                                                      
REMARK 465     ARG K   566                                                      
REMARK 465     GLU K   567                                                      
REMARK 465     PHE K   568                                                      
REMARK 465     GLU K   569                                                      
REMARK 465     VAL K   570                                                      
REMARK 465     GLU K   571                                                      
REMARK 465     LYS K   572                                                      
REMARK 465     GLN K   573                                                      
REMARK 465     THR K   574                                                      
REMARK 465     ALA K   575                                                      
REMARK 465     GLU K   576                                                      
REMARK 465     GLU K   577                                                      
REMARK 465     THR K   578                                                      
REMARK 465     GLY K   579                                                      
REMARK 465     LEU K   580                                                      
REMARK 465     THR K   581                                                      
REMARK 465     PRO K   582                                                      
REMARK 465     LEU K   583                                                      
REMARK 465     GLU K   584                                                      
REMARK 465     THR K   585                                                      
REMARK 465     SER K   586                                                      
REMARK 465     ARG K   587                                                      
REMARK 465     LYS K   588                                                      
REMARK 465     THR K   589                                                      
REMARK 465     PRO K   590                                                      
REMARK 465     ASP K   591                                                      
REMARK 465     SER K   592                                                      
REMARK 465     ARG K   593                                                      
REMARK 465     PRO K   594                                                      
REMARK 465     SER K   595                                                      
REMARK 465     LEU K   596                                                      
REMARK 465     GLU K   597                                                      
REMARK 465     GLU K   598                                                      
REMARK 465     THR K   599                                                      
REMARK 465     PHE K   600                                                      
REMARK 465     GLU K   601                                                      
REMARK 465     ILE K   602                                                      
REMARK 465     GLU K   603                                                      
REMARK 465     MET K   604                                                      
REMARK 465     ASN K   605                                                      
REMARK 465     GLU K   606                                                      
REMARK 465     SER K   607                                                      
REMARK 465     ASP K   608                                                      
REMARK 465     MET K   609                                                      
REMARK 465     MET K   610                                                      
REMARK 465     LEU K   611                                                      
REMARK 465     GLU K   612                                                      
REMARK 465     THR K   613                                                      
REMARK 465     SER K   614                                                      
REMARK 465     MET K   615                                                      
REMARK 465     SER K   616                                                      
REMARK 465     ASP K   617                                                      
REMARK 465     HIS K   618                                                      
REMARK 465     SER K   619                                                      
REMARK 465     THR K   620                                                      
REMARK 465     MET L     1                                                      
REMARK 465     THR L     2                                                      
REMARK 465     ARG L   171A                                                     
REMARK 465     GLU M    40                                                      
REMARK 465     GLN M    41                                                      
REMARK 465     ASP M    42                                                      
REMARK 465     ASN M    43                                                      
REMARK 465     GLY M    44                                                      
REMARK 465     GLY M    45                                                      
REMARK 465     THR M    46                                                      
REMARK 465     THR M    47                                                      
REMARK 465     ASN M    68                                                      
REMARK 465     VAL M    69                                                      
REMARK 465     PRO M    70                                                      
REMARK 465     PRO M    71                                                      
REMARK 465     ILE M    72                                                      
REMARK 465     GLY M    73                                                      
REMARK 465     ASN M    74                                                      
REMARK 465     MET N     1                                                      
REMARK 465     ALA N     2                                                      
REMARK 465     ALA N     3                                                      
REMARK 465     ALA N     4                                                      
REMARK 465     VAL N     5                                                      
REMARK 465     VAL N     6                                                      
REMARK 465     VAL N     7                                                      
REMARK 465     ALA N     8                                                      
REMARK 465     GLU N     9                                                      
REMARK 465     GLY N    10                                                      
REMARK 465     ASP N    11                                                      
REMARK 465     SER N    12                                                      
REMARK 465     ASP N    13                                                      
REMARK 465     SER N    14                                                      
REMARK 465     PRO N    34                                                      
REMARK 465     ALA N    35                                                      
REMARK 465     ALA N    36                                                      
REMARK 465     LEU N    37                                                      
REMARK 465     GLY N    38                                                      
REMARK 465     LEU N    39                                                      
REMARK 465     VAL N    40                                                      
REMARK 465     SER N    41                                                      
REMARK 465     SER N    42                                                      
REMARK 465     ARG N    43                                                      
REMARK 465     THR N    44                                                      
REMARK 465     SER N    45                                                      
REMARK 465     GLY N    46                                                      
REMARK 465     ALA N    47                                                      
REMARK 465     VAL N    48                                                      
REMARK 465     PRO N    49                                                      
REMARK 465     GLU N   192                                                      
REMARK 465     GLY N   193                                                      
REMARK 465     GLY N   194                                                      
REMARK 465     THR N   195                                                      
REMARK 465     ASP N   196                                                      
REMARK 465     PRO N   197                                                      
REMARK 465     GLU N   198                                                      
REMARK 465     LEU N   199                                                      
REMARK 465     GLU N   200                                                      
REMARK 465     GLY N   201                                                      
REMARK 465     GLU N   202                                                      
REMARK 465     LEU N   203                                                      
REMARK 465     ASP N   204                                                      
REMARK 465     SER N   205                                                      
REMARK 465     ARG N   206                                                      
REMARK 465     TYR N   207                                                      
REMARK 465     ALA N   208                                                      
REMARK 465     ARG N   209                                                      
REMARK 465     ARG N   210                                                      
REMARK 465     ARG N   211                                                      
REMARK 465     TYR N   212                                                      
REMARK 465     TYR N   213                                                      
REMARK 465     ARG N   214                                                      
REMARK 465     LEU N   215                                                      
REMARK 465     LEU N   216                                                      
REMARK 465     GLN N   217                                                      
REMARK 465     SER N   218                                                      
REMARK 465     PRO N   219                                                      
REMARK 465     LEU N   220                                                      
REMARK 465     CYS N   221                                                      
REMARK 465     ALA N   222                                                      
REMARK 465     GLY N   223                                                      
REMARK 465     CYS N   224                                                      
REMARK 465     SER N   225                                                      
REMARK 465     SER N   226                                                      
REMARK 465     ASP N   227                                                      
REMARK 465     LYS N   228                                                      
REMARK 465     GLN N   229                                                      
REMARK 465     GLN N   230                                                      
REMARK 465     CYS N   231                                                      
REMARK 465     LEU N   305                                                      
REMARK 465     GLN N   306                                                      
REMARK 465     ASP N   307                                                      
REMARK 465     GLY N   308                                                      
REMARK 465     PRO N   309                                                      
REMARK 465     ALA N   310                                                      
REMARK 465     ARG N   311                                                      
REMARK 465     PRO N   312                                                      
REMARK 465     ALA N   313                                                      
REMARK 465     SER N   314                                                      
REMARK 465     PRO N   315                                                      
REMARK 465     GLU N   316                                                      
REMARK 465     ALA N   317                                                      
REMARK 465     GLY N   318                                                      
REMARK 465     GLY N   444                                                      
REMARK 465     ASP N   445                                                      
REMARK 465     SER N   446                                                      
REMARK 465     ASP N   447                                                      
REMARK 465     GLY N   448                                                      
REMARK 465     THR N   449                                                      
REMARK 465     GLY N   450                                                      
REMARK 465     ASP N   451                                                      
REMARK 465     LEU N   452                                                      
REMARK 465     ALA N   453                                                      
REMARK 465     VAL N   454                                                      
REMARK 465     GLU N   455                                                      
REMARK 465     LEU N   456                                                      
REMARK 465     SER N   457                                                      
REMARK 465     LYS N   458                                                      
REMARK 465     THR N   459                                                      
REMARK 465     ASP N   460                                                      
REMARK 465     PRO N   461                                                      
REMARK 465     ALA N   462                                                      
REMARK 465     SER N   463                                                      
REMARK 465     LEU N   464                                                      
REMARK 465     GLU N   465                                                      
REMARK 465     THR N   466                                                      
REMARK 465     GLY N   467                                                      
REMARK 465     GLN N   468                                                      
REMARK 465     ASP N   469                                                      
REMARK 465     SER N   470                                                      
REMARK 465     GLU N   471                                                      
REMARK 465     ASP N   472                                                      
REMARK 465     ASP N   473                                                      
REMARK 465     ALA N   487                                                      
REMARK 465     ASP N   488                                                      
REMARK 465     PRO N   489                                                      
REMARK 465     GLY N   490                                                      
REMARK 465     LYS N   491                                                      
REMARK 465     SER N   492                                                      
REMARK 465     SER N   493                                                      
REMARK 465     SER N   494                                                      
REMARK 465     LYS N   495                                                      
REMARK 465     ARG N   496                                                      
REMARK 465     ARG N   497                                                      
REMARK 465     SER N   498                                                      
REMARK 465     ASP N   731                                                      
REMARK 465     SER N   732                                                      
REMARK 465     ASP N   733                                                      
REMARK 465     ASP N   734                                                      
REMARK 465     GLU N   735                                                      
REMARK 465     SER N   736                                                      
REMARK 465     ASP N   737                                                      
REMARK 465     SER N   738                                                      
REMARK 465     GLY N   739                                                      
REMARK 465     MET N   740                                                      
REMARK 465     ALA N   741                                                      
REMARK 465     SER N   742                                                      
REMARK 465     GLN N   743                                                      
REMARK 465     ALA N   744                                                      
REMARK 465     ASP N   745                                                      
REMARK 465     GLN N   746                                                      
REMARK 465     LYS N   819                                                      
REMARK 465     ASN N   820                                                      
REMARK 465     CYS N   821                                                      
REMARK 465     SER N   822                                                      
REMARK 465     MET O     1                                                      
REMARK 465     ALA O     2                                                      
REMARK 465     SER O     3                                                      
REMARK 465     VAL O     4                                                      
REMARK 465     HIS O     5                                                      
REMARK 465     GLU O     6                                                      
REMARK 465     SER O     7                                                      
REMARK 465     LEU O     8                                                      
REMARK 465     TYR O     9                                                      
REMARK 465     PHE O    10                                                      
REMARK 465     ASN O    11                                                      
REMARK 465     PRO O    12                                                      
REMARK 465     MET O    13                                                      
REMARK 465     MET O    14                                                      
REMARK 465     THR O    15                                                      
REMARK 465     ASN O    16                                                      
REMARK 465     GLY O    17                                                      
REMARK 465     VAL O    18                                                      
REMARK 465     VAL O    19                                                      
REMARK 465     HIS O    20                                                      
REMARK 465     ALA O    21                                                      
REMARK 465     ASN O    22                                                      
REMARK 465     VAL O    23                                                      
REMARK 465     PHE O    24                                                      
REMARK 465     LYS O   168                                                      
REMARK 465     THR O   169                                                      
REMARK 465     VAL O   170                                                      
REMARK 465     GLU O   171                                                      
REMARK 465     ASP O   172                                                      
REMARK 465     ALA O   173                                                      
REMARK 465     ASP O   174                                                      
REMARK 465     MET O   175                                                      
REMARK 465     GLU O   176                                                      
REMARK 465     LEU O   177                                                      
REMARK 465     THR O   178                                                      
REMARK 465     SER O   179                                                      
REMARK 465     ARG O   180                                                      
REMARK 465     ASP O   181                                                      
REMARK 465     GLU O   182                                                      
REMARK 465     GLY O   183                                                      
REMARK 465     GLU O   184                                                      
REMARK 465     ARG O   185                                                      
REMARK 465     LYS O   186                                                      
REMARK 465     MET O   187                                                      
REMARK 465     GLU O   188                                                      
REMARK 465     LYS O   189                                                      
REMARK 465     GLU O   190                                                      
REMARK 465     GLU O   191                                                      
REMARK 465     LEU O   192                                                      
REMARK 465     ASP O   193                                                      
REMARK 465     VAL O   194                                                      
REMARK 465     SER O   195                                                      
REMARK 465     VAL O   196                                                      
REMARK 465     ARG O   197                                                      
REMARK 465     GLU O   198                                                      
REMARK 465     GLU O   199                                                      
REMARK 465     GLU O   200                                                      
REMARK 465     VAL O   201                                                      
REMARK 465     SER O   202                                                      
REMARK 465     CYS O   203                                                      
REMARK 465     SER O   204                                                      
REMARK 465     GLY O   205                                                      
REMARK 465     ALA O   453                                                      
REMARK 465     VAL O   454                                                      
REMARK 465     ASN O   455                                                      
REMARK 465     ALA O   456                                                      
REMARK 465     GLY O   457                                                      
REMARK 465     MET P     1                                                      
REMARK 465     ALA P     2                                                      
REMARK 465     ALA P     3                                                      
REMARK 465     SER P     4                                                      
REMARK 465     THR P     5                                                      
REMARK 465     SER P     6                                                      
REMARK 465     MET P     7                                                      
REMARK 465     VAL P     8                                                      
REMARK 465     PRO P     9                                                      
REMARK 465     VAL P    10                                                      
REMARK 465     ALA P    11                                                      
REMARK 465     VAL P    12                                                      
REMARK 465     THR P    13                                                      
REMARK 465     ALA P    14                                                      
REMARK 465     ALA P    15                                                      
REMARK 465     VAL P    16                                                      
REMARK 465     ALA P    17                                                      
REMARK 465     PRO P    18                                                      
REMARK 465     VAL P    19                                                      
REMARK 465     LEU P    20                                                      
REMARK 465     SER P    21                                                      
REMARK 465     ILE P    22                                                      
REMARK 465     ASN P    23                                                      
REMARK 465     SER P    24                                                      
REMARK 465     ASP P    25                                                      
REMARK 465     VAL P   135                                                      
REMARK 465     ASP P   136                                                      
REMARK 465     SER P   137                                                      
REMARK 465     LEU P   138                                                      
REMARK 465     GLY P   139                                                      
REMARK 465     PRO P   140                                                      
REMARK 465     LEU P   141                                                      
REMARK 465     GLU P   142                                                      
REMARK 465     LYS P   143                                                      
REMARK 465     GLY P   144                                                      
REMARK 465     GLN P   145                                                      
REMARK 465     GLY P   501                                                      
REMARK 465     GLU P   502                                                      
REMARK 465     ILE P   503                                                      
REMARK 465     VAL P   504                                                      
REMARK 465     GLU P   505                                                      
REMARK 465     HIS P   506                                                      
REMARK 465     LEU P   507                                                      
REMARK 465     GLU P   508                                                      
REMARK 465     GLU P   509                                                      
REMARK 465     SER P   510                                                      
REMARK 465     PHE P   539                                                      
REMARK 465     ASN P   540                                                      
REMARK 465     ASP P   541                                                      
REMARK 465     THR P   542                                                      
REMARK 465     ARG P   543                                                      
REMARK 465     GLU P   544                                                      
REMARK 465     GLU P   545                                                      
REMARK 465     GLY P   546                                                      
REMARK 465     LYS P   547                                                      
REMARK 465     ALA P   548                                                      
REMARK 465     LEU P   549                                                      
REMARK 465     LEU P   550                                                      
REMARK 465     ARG P   551                                                      
REMARK 465     GLN P   552                                                      
REMARK 465     ILE P   553                                                      
REMARK 465     LEU P   554                                                      
REMARK 465     GLN P   555                                                      
REMARK 465     LEU P   556                                                      
REMARK 465     ARG P   557                                                      
REMARK 465     ASN P   558                                                      
REMARK 465     GLN P   559                                                      
REMARK 465     GLY P   560                                                      
REMARK 465     GLU P   561                                                      
REMARK 465     THR P   562                                                      
REMARK 465     PRO P   563                                                      
REMARK 465     THR P   564                                                      
REMARK 465     THR P   565                                                      
REMARK 465     GLU P   566                                                      
REMARK 465     VAL P   567                                                      
REMARK 465     PRO P   568                                                      
REMARK 465     ALA P   569                                                      
REMARK 465     PRO P   570                                                      
REMARK 465     PHE P   571                                                      
REMARK 465     PHE P   572                                                      
REMARK 465     LEU P   573                                                      
REMARK 465     PRO P   574                                                      
REMARK 465     ALA P   575                                                      
REMARK 465     SER P   576                                                      
REMARK 465     LEU P   577                                                      
REMARK 465     SER P   578                                                      
REMARK 465     ALA P   579                                                      
REMARK 465     ASN P   580                                                      
REMARK 465     ASN P   581                                                      
REMARK 465     THR P   582                                                      
REMARK 465     PRO P   583                                                      
REMARK 465     THR P   584                                                      
REMARK 465     ARG P   585                                                      
REMARK 465     ARG P   586                                                      
REMARK 465     VAL P   587                                                      
REMARK 465     SER P   588                                                      
REMARK 465     PRO P   589                                                      
REMARK 465     LEU P   590                                                      
REMARK 465     ASN P   591                                                      
REMARK 465     LEU P   592                                                      
REMARK 465     SER P   593                                                      
REMARK 465     SER P   594                                                      
REMARK 465     VAL P   595                                                      
REMARK 465     THR P   596                                                      
REMARK 465     PRO P   597                                                      
REMARK 465     GLU W    27                                                      
REMARK 465     THR W    28                                                      
REMARK 465     ARG W    29                                                      
REMARK 465     LYS W    30                                                      
REMARK 465     LYS W    31                                                      
REMARK 465     GLN W    32                                                      
REMARK 465     LYS W    33                                                      
REMARK 465     GLU W    34                                                      
REMARK 465     ASP W    35                                                      
REMARK 465     VAL W    36                                                      
REMARK 465     GLU W    37                                                      
REMARK 465     VAL W    38                                                      
REMARK 465     VAL W    39                                                      
REMARK 465     GLY W    40                                                      
REMARK 465     GLY W    41                                                      
REMARK 465     SER W    42                                                      
REMARK 465     ASP W    43                                                      
REMARK 465     GLY W    44                                                      
REMARK 465     GLU W    45                                                      
REMARK 465     GLY W    46                                                      
REMARK 465     ALA W    47                                                      
REMARK 465     ILE W    48                                                      
REMARK 465     GLY W    49                                                      
REMARK 465     LEU W    50                                                      
REMARK 465     SER W    51                                                      
REMARK 465     SER W    52                                                      
REMARK 465     ASP W    53                                                      
REMARK 465     PRO W    54                                                      
REMARK 465     LYS W    55                                                      
REMARK 465     SER W    56                                                      
REMARK 465     ARG W    57                                                      
REMARK 465     GLU W    58                                                      
REMARK 465     GLN W    59                                                      
REMARK 465     MET W    60                                                      
REMARK 465     ILE W    61                                                      
REMARK 465     ASN W    62                                                      
REMARK 465     ASP W    63                                                      
REMARK 465     ARG W    64                                                      
REMARK 465     ILE W    65                                                      
REMARK 465     GLY W    66                                                      
REMARK 465     TYR W    67                                                      
REMARK 465     LYS W    68                                                      
REMARK 465     PRO W    69                                                      
REMARK 465     GLN W    70                                                      
REMARK 465     PRO W    71                                                      
REMARK 465     LYS W    72                                                      
REMARK 465     PRO W    73                                                      
REMARK 465     ASN W    74                                                      
REMARK 465     ASN W    75                                                      
REMARK 465     ARG W    76                                                      
REMARK 465     SER W    77                                                      
REMARK 465     SER W    78                                                      
REMARK 465     GLN W    79                                                      
REMARK 465     PHE W    80                                                      
REMARK 465     GLY W    81                                                      
REMARK 465     SER W    82                                                      
REMARK 465     LEU W    83                                                      
REMARK 465     GLU W    84                                                      
REMARK 465     PHE W    85                                                      
REMARK 465     MET X     1                                                      
REMARK 465     ASP X     2                                                      
REMARK 465     PRO X     3                                                      
REMARK 465     GLY X     4                                                      
REMARK 465     ASP X     5                                                      
REMARK 465     ALA X     6                                                      
REMARK 465     ALA X     7                                                      
REMARK 465     ILE X     8                                                      
REMARK 465     LEU X     9                                                      
REMARK 465     GLU X    10                                                      
REMARK 465     SER X    11                                                      
REMARK 465     SER X    12                                                      
REMARK 465     LEU X    13                                                      
REMARK 465     ARG X    14                                                      
REMARK 465     ILE X    15                                                      
REMARK 465     LEU X    16                                                      
REMARK 465     TYR X    17                                                      
REMARK 465     ARG X    18                                                      
REMARK 465     LEU X    19                                                      
REMARK 465     PHE X    20                                                      
REMARK 465     GLU X    21                                                      
REMARK 465     SER X    22                                                      
REMARK 465     VAL X    23                                                      
REMARK 465     LEU X    24                                                      
REMARK 465     PRO X    25                                                      
REMARK 465     PRO X    26                                                      
REMARK 465     LEU X    27                                                      
REMARK 465     PRO X    28                                                      
REMARK 465     ALA X    29                                                      
REMARK 465     ALA X    30                                                      
REMARK 465     LEU X    31                                                      
REMARK 465     GLN X    32                                                      
REMARK 465     SER X    33                                                      
REMARK 465     ARG X    34                                                      
REMARK 465     MET X    35                                                      
REMARK 465     SER X   111                                                      
REMARK 465     LYS X   112                                                      
REMARK 465     THR X   113                                                      
REMARK 465     SER X   114                                                      
REMARK 465     LYS X   115                                                      
REMARK 465     VAL X   116                                                      
REMARK 465     ARG X   117                                                      
REMARK 465     PRO X   118                                                      
REMARK 465     SER X   119                                                      
REMARK 465     THR X   120                                                      
REMARK 465     GLY X   121                                                      
REMARK 465     ASN X   122                                                      
REMARK 465     SER X   123                                                      
REMARK 465     ALA X   124                                                      
REMARK 465     SER X   125                                                      
REMARK 465     THR X   126                                                      
REMARK 465     PRO X   127                                                      
REMARK 465     GLN X   128                                                      
REMARK 465     SER X   129                                                      
REMARK 465     GLN X   130                                                      
REMARK 465     CYS X   131                                                      
REMARK 465     ASN X   541                                                      
REMARK 465     ASP X   542                                                      
REMARK 465     GLN X   543                                                      
REMARK 465     LYS X   544                                                      
REMARK 465     SER X   545                                                      
REMARK 465     LEU X   546                                                      
REMARK 465     GLU X   547                                                      
REMARK 465     GLY X   548                                                      
REMARK 465     MET X   549                                                      
REMARK 465     GLN X   550                                                      
REMARK 465     LYS X   551                                                      
REMARK 465     MET X   552                                                      
REMARK 465     GLU X   553                                                      
REMARK 465     LYS X   554                                                      
REMARK 465     GLU X   555                                                      
REMARK 465     GLU X   556                                                      
REMARK 465     SER X   557                                                      
REMARK 465     PRO X   558                                                      
REMARK 465     THR X   559                                                      
REMARK 465     ASP X   560                                                      
REMARK 465     ALA X   561                                                      
REMARK 465     THR X   562                                                      
REMARK 465     GLN X   563                                                      
REMARK 465     GLU X   564                                                      
REMARK 465     GLU X   565                                                      
REMARK 465     ASP X   566                                                      
REMARK 465     VAL X   567                                                      
REMARK 465     ASP X   568                                                      
REMARK 465     ASP X   569                                                      
REMARK 465     MET X   570                                                      
REMARK 465     GLU X   571                                                      
REMARK 465     GLY X   572                                                      
REMARK 465     SER X   573                                                      
REMARK 465     GLY X   574                                                      
REMARK 465     GLU X   575                                                      
REMARK 465     GLU X   576                                                      
REMARK 465     GLY X   577                                                      
REMARK 465     ASP X   578                                                      
REMARK 465     LEU X   579                                                      
REMARK 465     GLU X   580                                                      
REMARK 465     GLY X   581                                                      
REMARK 465     SER X   582                                                      
REMARK 465     ASP X   583                                                      
REMARK 465     SER X   584                                                      
REMARK 465     GLU X   585                                                      
REMARK 465     ALA X   586                                                      
REMARK 465     ALA X   587                                                      
REMARK 465     GLN X   588                                                      
REMARK 465     TRP X   589                                                      
REMARK 465     ALA X   590                                                      
REMARK 465     ASP X   591                                                      
REMARK 465     GLN X   592                                                      
REMARK 465     GLU X   593                                                      
REMARK 465     GLN X   594                                                      
REMARK 465     TRP X   595                                                      
REMARK 465     PHE X   596                                                      
REMARK 465     GLY X   597                                                      
REMARK 465     MET X   598                                                      
REMARK 465     GLN X   599                                                      
REMARK 465     MET Y     1                                                      
REMARK 465     ASP Y     2                                                      
REMARK 465     PRO Y     3                                                      
REMARK 465     GLY Y     4                                                      
REMARK 465     ASP Y     5                                                      
REMARK 465     ALA Y     6                                                      
REMARK 465     ALA Y     7                                                      
REMARK 465     ILE Y     8                                                      
REMARK 465     LEU Y     9                                                      
REMARK 465     GLU Y    10                                                      
REMARK 465     SER Y    11                                                      
REMARK 465     SER Y    12                                                      
REMARK 465     LEU Y    13                                                      
REMARK 465     ARG Y    14                                                      
REMARK 465     ILE Y    15                                                      
REMARK 465     LEU Y    16                                                      
REMARK 465     TYR Y    17                                                      
REMARK 465     ARG Y    18                                                      
REMARK 465     LEU Y    19                                                      
REMARK 465     PHE Y    20                                                      
REMARK 465     GLU Y    21                                                      
REMARK 465     SER Y    22                                                      
REMARK 465     VAL Y    23                                                      
REMARK 465     LEU Y    24                                                      
REMARK 465     PRO Y    25                                                      
REMARK 465     PRO Y    26                                                      
REMARK 465     LEU Y    27                                                      
REMARK 465     PRO Y    28                                                      
REMARK 465     ALA Y    29                                                      
REMARK 465     ALA Y    30                                                      
REMARK 465     LEU Y    31                                                      
REMARK 465     GLN Y    32                                                      
REMARK 465     SER Y    33                                                      
REMARK 465     ARG Y    34                                                      
REMARK 465     MET Y    35                                                      
REMARK 465     SER Y   111                                                      
REMARK 465     LYS Y   112                                                      
REMARK 465     THR Y   113                                                      
REMARK 465     SER Y   114                                                      
REMARK 465     LYS Y   115                                                      
REMARK 465     VAL Y   116                                                      
REMARK 465     ARG Y   117                                                      
REMARK 465     PRO Y   118                                                      
REMARK 465     SER Y   119                                                      
REMARK 465     THR Y   120                                                      
REMARK 465     GLY Y   121                                                      
REMARK 465     ASN Y   122                                                      
REMARK 465     SER Y   123                                                      
REMARK 465     ALA Y   124                                                      
REMARK 465     SER Y   125                                                      
REMARK 465     THR Y   126                                                      
REMARK 465     PRO Y   127                                                      
REMARK 465     GLN Y   128                                                      
REMARK 465     SER Y   129                                                      
REMARK 465     GLN Y   130                                                      
REMARK 465     CYS Y   131                                                      
REMARK 465     GLU Y   553                                                      
REMARK 465     LYS Y   554                                                      
REMARK 465     GLU Y   555                                                      
REMARK 465     GLU Y   556                                                      
REMARK 465     SER Y   557                                                      
REMARK 465     PRO Y   558                                                      
REMARK 465     THR Y   559                                                      
REMARK 465     ASP Y   560                                                      
REMARK 465     ALA Y   561                                                      
REMARK 465     THR Y   562                                                      
REMARK 465     GLN Y   563                                                      
REMARK 465     GLU Y   564                                                      
REMARK 465     GLU Y   565                                                      
REMARK 465     ASP Y   566                                                      
REMARK 465     VAL Y   567                                                      
REMARK 465     ASP Y   568                                                      
REMARK 465     ASP Y   569                                                      
REMARK 465     MET Y   570                                                      
REMARK 465     GLU Y   571                                                      
REMARK 465     GLY Y   572                                                      
REMARK 465     SER Y   573                                                      
REMARK 465     GLY Y   574                                                      
REMARK 465     GLU Y   575                                                      
REMARK 465     GLU Y   576                                                      
REMARK 465     GLY Y   577                                                      
REMARK 465     ASP Y   578                                                      
REMARK 465     LEU Y   579                                                      
REMARK 465     GLU Y   580                                                      
REMARK 465     GLY Y   581                                                      
REMARK 465     SER Y   582                                                      
REMARK 465     ASP Y   583                                                      
REMARK 465     SER Y   584                                                      
REMARK 465     GLU Y   585                                                      
REMARK 465     ALA Y   586                                                      
REMARK 465     ALA Y   587                                                      
REMARK 465     GLN Y   588                                                      
REMARK 465     TRP Y   589                                                      
REMARK 465     ALA Y   590                                                      
REMARK 465     ASP Y   591                                                      
REMARK 465     GLN Y   592                                                      
REMARK 465     GLU Y   593                                                      
REMARK 465     GLN Y   594                                                      
REMARK 465     TRP Y   595                                                      
REMARK 465     PHE Y   596                                                      
REMARK 465     GLY Y   597                                                      
REMARK 465     MET Y   598                                                      
REMARK 465     GLN Y   599                                                      
REMARK 465     MET S    55                                                      
REMARK 465     PRO S    56                                                      
REMARK 465     SER S    57                                                      
REMARK 465     ARG S    58                                                      
REMARK 465     ALA S    59                                                      
REMARK 465     GLU S    60                                                      
REMARK 465     ASP S    61                                                      
REMARK 465     TYR S    62                                                      
REMARK 465     GLU S    63                                                      
REMARK 465     VAL S    64                                                      
REMARK 465     LEU S    65                                                      
REMARK 465     TYR S    66                                                      
REMARK 465     THR S    67                                                      
REMARK 465     ILE S    68                                                      
REMARK 465     GLY S    69                                                      
REMARK 465     THR S    70                                                      
REMARK 465     GLY S    71                                                      
REMARK 465     SER S    72                                                      
REMARK 465     TYR S    73                                                      
REMARK 465     GLY S    74                                                      
REMARK 465     ARG S    75                                                      
REMARK 465     CYS S    76                                                      
REMARK 465     GLN S    77                                                      
REMARK 465     LYS S    78                                                      
REMARK 465     ILE S    79                                                      
REMARK 465     ARG S    80                                                      
REMARK 465     ARG S    81                                                      
REMARK 465     LYS S    82                                                      
REMARK 465     SER S    83                                                      
REMARK 465     ASP S    84                                                      
REMARK 465     GLY S    85                                                      
REMARK 465     LYS S    86                                                      
REMARK 465     ILE S    87                                                      
REMARK 465     LEU S    88                                                      
REMARK 465     VAL S    89                                                      
REMARK 465     TRP S    90                                                      
REMARK 465     LYS S    91                                                      
REMARK 465     GLU S    92                                                      
REMARK 465     LEU S    93                                                      
REMARK 465     ASP S    94                                                      
REMARK 465     TYR S    95                                                      
REMARK 465     GLY S    96                                                      
REMARK 465     SER S    97                                                      
REMARK 465     MET S    98                                                      
REMARK 465     THR S    99                                                      
REMARK 465     GLU S   100                                                      
REMARK 465     ALA S   101                                                      
REMARK 465     GLU S   102                                                      
REMARK 465     LYS S   103                                                      
REMARK 465     GLN S   104                                                      
REMARK 465     MET S   105                                                      
REMARK 465     LEU S   106                                                      
REMARK 465     VAL S   107                                                      
REMARK 465     SER S   108                                                      
REMARK 465     GLU S   109                                                      
REMARK 465     VAL S   110                                                      
REMARK 465     ASN S   111                                                      
REMARK 465     LEU S   112                                                      
REMARK 465     LEU S   113                                                      
REMARK 465     ARG S   114                                                      
REMARK 465     GLU S   115                                                      
REMARK 465     LEU S   116                                                      
REMARK 465     LYS S   117                                                      
REMARK 465     HIS S   118                                                      
REMARK 465     PRO S   119                                                      
REMARK 465     ASN S   120                                                      
REMARK 465     ILE S   121                                                      
REMARK 465     VAL S   122                                                      
REMARK 465     ARG S   123                                                      
REMARK 465     TYR S   124                                                      
REMARK 465     TYR S   125                                                      
REMARK 465     ASP S   126                                                      
REMARK 465     ARG S   127                                                      
REMARK 465     ILE S   128                                                      
REMARK 465     ILE S   129                                                      
REMARK 465     ASP S   130                                                      
REMARK 465     ARG S   131                                                      
REMARK 465     THR S   132                                                      
REMARK 465     ASN S   133                                                      
REMARK 465     THR S   134                                                      
REMARK 465     THR S   135                                                      
REMARK 465     LEU S   136                                                      
REMARK 465     TYR S   137                                                      
REMARK 465     ILE S   138                                                      
REMARK 465     VAL S   139                                                      
REMARK 465     MET S   140                                                      
REMARK 465     GLU S   141                                                      
REMARK 465     TYR S   142                                                      
REMARK 465     CYS S   143                                                      
REMARK 465     GLU S   144                                                      
REMARK 465     GLY S   145                                                      
REMARK 465     GLY S   146                                                      
REMARK 465     ASP S   147                                                      
REMARK 465     LEU S   148                                                      
REMARK 465     ALA S   149                                                      
REMARK 465     SER S   150                                                      
REMARK 465     VAL S   151                                                      
REMARK 465     ILE S   152                                                      
REMARK 465     THR S   153                                                      
REMARK 465     LYS S   154                                                      
REMARK 465     GLY S   155                                                      
REMARK 465     THR S   156                                                      
REMARK 465     LYS S   157                                                      
REMARK 465     GLU S   158                                                      
REMARK 465     ARG S   159                                                      
REMARK 465     GLN S   160                                                      
REMARK 465     TYR S   161                                                      
REMARK 465     LEU S   162                                                      
REMARK 465     ASP S   163                                                      
REMARK 465     GLU S   164                                                      
REMARK 465     GLU S   165                                                      
REMARK 465     PHE S   166                                                      
REMARK 465     VAL S   167                                                      
REMARK 465     LEU S   168                                                      
REMARK 465     ARG S   169                                                      
REMARK 465     VAL S   170                                                      
REMARK 465     MET S   171                                                      
REMARK 465     THR S   172                                                      
REMARK 465     GLN S   173                                                      
REMARK 465     LEU S   174                                                      
REMARK 465     THR S   175                                                      
REMARK 465     LEU S   176                                                      
REMARK 465     ALA S   177                                                      
REMARK 465     LEU S   178                                                      
REMARK 465     LYS S   179                                                      
REMARK 465     GLU S   180                                                      
REMARK 465     CYS S   181                                                      
REMARK 465     HIS S   182                                                      
REMARK 465     ARG S   183                                                      
REMARK 465     ARG S   184                                                      
REMARK 465     SER S   185                                                      
REMARK 465     ASP S   186                                                      
REMARK 465     GLY S   187                                                      
REMARK 465     GLY S   188                                                      
REMARK 465     HIS S   189                                                      
REMARK 465     THR S   190                                                      
REMARK 465     VAL S   191                                                      
REMARK 465     LEU S   192                                                      
REMARK 465     HIS S   193                                                      
REMARK 465     ARG S   194                                                      
REMARK 465     ASP S   195                                                      
REMARK 465     LEU S   196                                                      
REMARK 465     LYS S   197                                                      
REMARK 465     PRO S   198                                                      
REMARK 465     ALA S   199                                                      
REMARK 465     ASN S   200                                                      
REMARK 465     VAL S   201                                                      
REMARK 465     PHE S   202                                                      
REMARK 465     LEU S   203                                                      
REMARK 465     ASP S   204                                                      
REMARK 465     GLY S   205                                                      
REMARK 465     LYS S   206                                                      
REMARK 465     GLN S   207                                                      
REMARK 465     ASN S   208                                                      
REMARK 465     VAL S   209                                                      
REMARK 465     LYS S   210                                                      
REMARK 465     LEU S   211                                                      
REMARK 465     GLY S   212                                                      
REMARK 465     ASP S   213                                                      
REMARK 465     PHE S   214                                                      
REMARK 465     GLY S   215                                                      
REMARK 465     LEU S   216                                                      
REMARK 465     ALA S   217                                                      
REMARK 465     ARG S   218                                                      
REMARK 465     ILE S   219                                                      
REMARK 465     LEU S   220                                                      
REMARK 465     ASN S   221                                                      
REMARK 465     HIS S   222                                                      
REMARK 465     ASP S   223                                                      
REMARK 465     THR S   224                                                      
REMARK 465     SER S   225                                                      
REMARK 465     PHE S   226                                                      
REMARK 465     ALA S   227                                                      
REMARK 465     LYS S   228                                                      
REMARK 465     THR S   229                                                      
REMARK 465     PHE S   230                                                      
REMARK 465     VAL S   231                                                      
REMARK 465     GLY S   232                                                      
REMARK 465     THR S   233                                                      
REMARK 465     PRO S   234                                                      
REMARK 465     TYR S   235                                                      
REMARK 465     TYR S   236                                                      
REMARK 465     MET S   237                                                      
REMARK 465     SER S   238                                                      
REMARK 465     PRO S   239                                                      
REMARK 465     GLU S   240                                                      
REMARK 465     GLN S   241                                                      
REMARK 465     MET S   242                                                      
REMARK 465     ASN S   243                                                      
REMARK 465     ARG S   244                                                      
REMARK 465     MET S   245                                                      
REMARK 465     SER S   246                                                      
REMARK 465     TYR S   247                                                      
REMARK 465     ASN S   248                                                      
REMARK 465     GLU S   249                                                      
REMARK 465     LYS S   250                                                      
REMARK 465     SER S   251                                                      
REMARK 465     ASP S   252                                                      
REMARK 465     ILE S   253                                                      
REMARK 465     TRP S   254                                                      
REMARK 465     SER S   255                                                      
REMARK 465     LEU S   256                                                      
REMARK 465     GLY S   257                                                      
REMARK 465     CYS S   258                                                      
REMARK 465     LEU S   259                                                      
REMARK 465     LEU S   260                                                      
REMARK 465     TYR S   261                                                      
REMARK 465     GLU S   262                                                      
REMARK 465     LEU S   263                                                      
REMARK 465     CYS S   264                                                      
REMARK 465     ALA S   265                                                      
REMARK 465     LEU S   266                                                      
REMARK 465     MET S   267                                                      
REMARK 465     PRO S   268                                                      
REMARK 465     PRO S   269                                                      
REMARK 465     PHE S   270                                                      
REMARK 465     THR S   271                                                      
REMARK 465     ALA S   272                                                      
REMARK 465     PHE S   273                                                      
REMARK 465     SER S   274                                                      
REMARK 465     GLN S   275                                                      
REMARK 465     LYS S   276                                                      
REMARK 465     GLU S   277                                                      
REMARK 465     LEU S   278                                                      
REMARK 465     ALA S   279                                                      
REMARK 465     GLY S   280                                                      
REMARK 465     LYS S   281                                                      
REMARK 465     ILE S   282                                                      
REMARK 465     ARG S   283                                                      
REMARK 465     GLU S   284                                                      
REMARK 465     GLY S   285                                                      
REMARK 465     LYS S   286                                                      
REMARK 465     PHE S   287                                                      
REMARK 465     ARG S   288                                                      
REMARK 465     ARG S   289                                                      
REMARK 465     ILE S   290                                                      
REMARK 465     PRO S   291                                                      
REMARK 465     TYR S   292                                                      
REMARK 465     ARG S   293                                                      
REMARK 465     TYR S   294                                                      
REMARK 465     SER S   295                                                      
REMARK 465     ASP S   296                                                      
REMARK 465     GLU S   297                                                      
REMARK 465     LEU S   298                                                      
REMARK 465     ASN S   299                                                      
REMARK 465     GLU S   300                                                      
REMARK 465     ILE S   301                                                      
REMARK 465     ILE S   302                                                      
REMARK 465     THR S   303                                                      
REMARK 465     ARG S   304                                                      
REMARK 465     MET S   305                                                      
REMARK 465     LEU S   306                                                      
REMARK 465     ASN S   307                                                      
REMARK 465     LEU S   308                                                      
REMARK 465     LYS S   309                                                      
REMARK 465     ASP S   310                                                      
REMARK 465     TYR S   311                                                      
REMARK 465     HIS S   312                                                      
REMARK 465     ARG S   313                                                      
REMARK 465     PRO S   314                                                      
REMARK 465     SER S   315                                                      
REMARK 465     VAL S   316                                                      
REMARK 465     GLU S   317                                                      
REMARK 465     GLU S   318                                                      
REMARK 465     ILE S   319                                                      
REMARK 465     LEU S   320                                                      
REMARK 465     GLU S   321                                                      
REMARK 465     ASN S   322                                                      
REMARK 465     PRO S   323                                                      
REMARK 465     LEU S   324                                                      
REMARK 465     ILE S   325                                                      
REMARK 465     ALA S   326                                                      
REMARK 465     ASP S   327                                                      
REMARK 465     LEU S   328                                                      
REMARK 465     VAL S   329                                                      
REMARK 465     ALA S   330                                                      
REMARK 465     ASP S   331                                                      
REMARK 465     GLU S   332                                                      
REMARK 465     GLN S   333                                                      
REMARK 465     ARG S   334                                                      
REMARK 465     ARG S   335                                                      
REMARK 465     ASN S   336                                                      
REMARK 465     LEU S   337                                                      
REMARK 465     GLU S   338                                                      
REMARK 465     ARG S   339                                                      
REMARK 465     ARG S   340                                                      
REMARK 465     GLY S   341                                                      
REMARK 465     ARG S   342                                                      
REMARK 465     GLN S   343                                                      
REMARK 465     LEU S   344                                                      
REMARK 465     GLY S   345                                                      
REMARK 465     GLU S   346                                                      
REMARK 465     PRO S   347                                                      
REMARK 465     GLU S   348                                                      
REMARK 465     LYS S   349                                                      
REMARK 465     SER S   350                                                      
REMARK 465     GLN S   351                                                      
REMARK 465     ASP S   352                                                      
REMARK 465     SER S   353                                                      
REMARK 465     SER S   354                                                      
REMARK 465     PRO S   355                                                      
REMARK 465     VAL S   356                                                      
REMARK 465     LEU S   357                                                      
REMARK 465     SER S   358                                                      
REMARK 465     GLU S   359                                                      
REMARK 465     LEU S   360                                                      
REMARK 465     LYS S   361                                                      
REMARK 465     LEU S   362                                                      
REMARK 465     LYS S   363                                                      
REMARK 465     GLU S   364                                                      
REMARK 465     ILE S   365                                                      
REMARK 465     GLN S   366                                                      
REMARK 465     LEU S   367                                                      
REMARK 465     GLN S   368                                                      
REMARK 465     GLU S   369                                                      
REMARK 465     ARG S   370                                                      
REMARK 465     GLU S   371                                                      
REMARK 465     ARG S   372                                                      
REMARK 465     ALA S   373                                                      
REMARK 465     LEU S   374                                                      
REMARK 465     LYS S   375                                                      
REMARK 465     ALA S   376                                                      
REMARK 465     ARG S   377                                                      
REMARK 465     GLU S   378                                                      
REMARK 465     GLU S   379                                                      
REMARK 465     ARG S   380                                                      
REMARK 465     LEU S   381                                                      
REMARK 465     GLU S   382                                                      
REMARK 465     GLN S   383                                                      
REMARK 465     LYS S   384                                                      
REMARK 465     GLU S   385                                                      
REMARK 465     GLN S   386                                                      
REMARK 465     GLU S   387                                                      
REMARK 465     LEU S   388                                                      
REMARK 465     CYS S   389                                                      
REMARK 465     VAL S   390                                                      
REMARK 465     ARG S   391                                                      
REMARK 465     GLU S   392                                                      
REMARK 465     ARG S   393                                                      
REMARK 465     LEU S   394                                                      
REMARK 465     ALA S   395                                                      
REMARK 465     GLU S   396                                                      
REMARK 465     ASP S   397                                                      
REMARK 465     LYS S   398                                                      
REMARK 465     LEU S   399                                                      
REMARK 465     ALA S   400                                                      
REMARK 465     ARG S   401                                                      
REMARK 465     ALA S   402                                                      
REMARK 465     GLU S   403                                                      
REMARK 465     ASN S   404                                                      
REMARK 465     LEU S   405                                                      
REMARK 465     LEU S   406                                                      
REMARK 465     LYS S   407                                                      
REMARK 465     ASN S   408                                                      
REMARK 465     TYR S   409                                                      
REMARK 465     SER S   410                                                      
REMARK 465     LEU S   411                                                      
REMARK 465     LEU S   412                                                      
REMARK 465     LYS S   413                                                      
REMARK 465     GLU S   414                                                      
REMARK 465     ARG S   415                                                      
REMARK 465     LYS S   416                                                      
REMARK 465     PHE S   417                                                      
REMARK 465     LEU S   418                                                      
REMARK 465     SER S   419                                                      
REMARK 465     LEU S   420                                                      
REMARK 465     ALA S   421                                                      
REMARK 465     SER S   422                                                      
REMARK 465     ASN S   423                                                      
REMARK 465     PRO S   424                                                      
REMARK 465     GLU S   425                                                      
REMARK 465     LEU S   426                                                      
REMARK 465     LEU S   427                                                      
REMARK 465     ASN S   428                                                      
REMARK 465     LEU S   429                                                      
REMARK 465     PRO S   430                                                      
REMARK 465     SER S   431                                                      
REMARK 465     SER S   432                                                      
REMARK 465     VAL S   433                                                      
REMARK 465     ILE S   434                                                      
REMARK 465     LYS S   435                                                      
REMARK 465     LYS S   436                                                      
REMARK 465     LYS S   437                                                      
REMARK 465     VAL S   438                                                      
REMARK 465     HIS S   439                                                      
REMARK 465     PHE S   440                                                      
REMARK 465     SER S   441                                                      
REMARK 465     GLY S   442                                                      
REMARK 465     GLU S   443                                                      
REMARK 465     SER S   444                                                      
REMARK 465     LYS S   445                                                      
REMARK 465     GLU S   446                                                      
REMARK 465     ASN S   447                                                      
REMARK 465     ILE S   448                                                      
REMARK 465     ALA S   449                                                      
REMARK 465     ARG S   450                                                      
REMARK 465     SER S   451                                                      
REMARK 465     GLU S   452                                                      
REMARK 465     ASN S   453                                                      
REMARK 465     SER S   454                                                      
REMARK 465     GLU S   455                                                      
REMARK 465     SER S   456                                                      
REMARK 465     GLN S   457                                                      
REMARK 465     LEU S   458                                                      
REMARK 465     THR S   459                                                      
REMARK 465     SER S   460                                                      
REMARK 465     LYS S   461                                                      
REMARK 465     SER S   462                                                      
REMARK 465     LYS S   463                                                      
REMARK 465     CYS S   464                                                      
REMARK 465     LYS S   465                                                      
REMARK 465     ASP S   466                                                      
REMARK 465     LEU S   467                                                      
REMARK 465     LYS S   468                                                      
REMARK 465     LYS S   469                                                      
REMARK 465     ARG S   470                                                      
REMARK 465     LEU S   471                                                      
REMARK 465     HIS S   472                                                      
REMARK 465     ALA S   473                                                      
REMARK 465     ALA S   474                                                      
REMARK 465     GLN S   475                                                      
REMARK 465     LEU S   476                                                      
REMARK 465     ARG S   477                                                      
REMARK 465     ALA S   478                                                      
REMARK 465     GLN S   479                                                      
REMARK 465     ALA S   480                                                      
REMARK 465     LEU S   481                                                      
REMARK 465     SER S   482                                                      
REMARK 465     ASP S   483                                                      
REMARK 465     ILE S   484                                                      
REMARK 465     GLU S   485                                                      
REMARK 465     LYS S   486                                                      
REMARK 465     ASN S   487                                                      
REMARK 465     TYR S   488                                                      
REMARK 465     GLN S   489                                                      
REMARK 465     LEU S   490                                                      
REMARK 465     LYS S   491                                                      
REMARK 465     SER S   492                                                      
REMARK 465     ARG S   493                                                      
REMARK 465     GLN S   494                                                      
REMARK 465     ILE S   495                                                      
REMARK 465     LEU S   496                                                      
REMARK 465     GLY S   497                                                      
REMARK 465     MET Q    55                                                      
REMARK 465     PRO Q    56                                                      
REMARK 465     SER Q    57                                                      
REMARK 465     ARG Q    58                                                      
REMARK 465     ALA Q    59                                                      
REMARK 465     GLU Q    60                                                      
REMARK 465     ASP Q    61                                                      
REMARK 465     TYR Q    62                                                      
REMARK 465     GLU Q    63                                                      
REMARK 465     VAL Q    64                                                      
REMARK 465     LEU Q    65                                                      
REMARK 465     TYR Q    66                                                      
REMARK 465     THR Q    67                                                      
REMARK 465     ILE Q    68                                                      
REMARK 465     GLY Q    69                                                      
REMARK 465     THR Q    70                                                      
REMARK 465     GLY Q    71                                                      
REMARK 465     SER Q    72                                                      
REMARK 465     TYR Q    73                                                      
REMARK 465     GLY Q    74                                                      
REMARK 465     ARG Q    75                                                      
REMARK 465     CYS Q    76                                                      
REMARK 465     GLN Q    77                                                      
REMARK 465     LYS Q    78                                                      
REMARK 465     ILE Q    79                                                      
REMARK 465     ARG Q    80                                                      
REMARK 465     ARG Q    81                                                      
REMARK 465     LYS Q    82                                                      
REMARK 465     SER Q    83                                                      
REMARK 465     ASP Q    84                                                      
REMARK 465     GLY Q    85                                                      
REMARK 465     LYS Q    86                                                      
REMARK 465     ILE Q    87                                                      
REMARK 465     LEU Q    88                                                      
REMARK 465     VAL Q    89                                                      
REMARK 465     TRP Q    90                                                      
REMARK 465     LYS Q    91                                                      
REMARK 465     GLU Q    92                                                      
REMARK 465     LEU Q    93                                                      
REMARK 465     ASP Q    94                                                      
REMARK 465     TYR Q    95                                                      
REMARK 465     GLY Q    96                                                      
REMARK 465     SER Q    97                                                      
REMARK 465     MET Q    98                                                      
REMARK 465     THR Q    99                                                      
REMARK 465     GLU Q   100                                                      
REMARK 465     ALA Q   101                                                      
REMARK 465     GLU Q   102                                                      
REMARK 465     LYS Q   103                                                      
REMARK 465     GLN Q   104                                                      
REMARK 465     MET Q   105                                                      
REMARK 465     LEU Q   106                                                      
REMARK 465     VAL Q   107                                                      
REMARK 465     SER Q   108                                                      
REMARK 465     GLU Q   109                                                      
REMARK 465     VAL Q   110                                                      
REMARK 465     ASN Q   111                                                      
REMARK 465     LEU Q   112                                                      
REMARK 465     LEU Q   113                                                      
REMARK 465     ARG Q   114                                                      
REMARK 465     GLU Q   115                                                      
REMARK 465     LEU Q   116                                                      
REMARK 465     LYS Q   117                                                      
REMARK 465     HIS Q   118                                                      
REMARK 465     PRO Q   119                                                      
REMARK 465     ASN Q   120                                                      
REMARK 465     ILE Q   121                                                      
REMARK 465     VAL Q   122                                                      
REMARK 465     ARG Q   123                                                      
REMARK 465     TYR Q   124                                                      
REMARK 465     TYR Q   125                                                      
REMARK 465     ASP Q   126                                                      
REMARK 465     ARG Q   127                                                      
REMARK 465     ILE Q   128                                                      
REMARK 465     ILE Q   129                                                      
REMARK 465     ASP Q   130                                                      
REMARK 465     ARG Q   131                                                      
REMARK 465     THR Q   132                                                      
REMARK 465     ASN Q   133                                                      
REMARK 465     THR Q   134                                                      
REMARK 465     THR Q   135                                                      
REMARK 465     LEU Q   136                                                      
REMARK 465     TYR Q   137                                                      
REMARK 465     ILE Q   138                                                      
REMARK 465     VAL Q   139                                                      
REMARK 465     MET Q   140                                                      
REMARK 465     GLU Q   141                                                      
REMARK 465     TYR Q   142                                                      
REMARK 465     CYS Q   143                                                      
REMARK 465     GLU Q   144                                                      
REMARK 465     GLY Q   145                                                      
REMARK 465     GLY Q   146                                                      
REMARK 465     ASP Q   147                                                      
REMARK 465     LEU Q   148                                                      
REMARK 465     ALA Q   149                                                      
REMARK 465     SER Q   150                                                      
REMARK 465     VAL Q   151                                                      
REMARK 465     ILE Q   152                                                      
REMARK 465     THR Q   153                                                      
REMARK 465     LYS Q   154                                                      
REMARK 465     GLY Q   155                                                      
REMARK 465     THR Q   156                                                      
REMARK 465     LYS Q   157                                                      
REMARK 465     GLU Q   158                                                      
REMARK 465     ARG Q   159                                                      
REMARK 465     GLN Q   160                                                      
REMARK 465     TYR Q   161                                                      
REMARK 465     LEU Q   162                                                      
REMARK 465     ASP Q   163                                                      
REMARK 465     GLU Q   164                                                      
REMARK 465     GLU Q   165                                                      
REMARK 465     PHE Q   166                                                      
REMARK 465     VAL Q   167                                                      
REMARK 465     LEU Q   168                                                      
REMARK 465     ARG Q   169                                                      
REMARK 465     VAL Q   170                                                      
REMARK 465     MET Q   171                                                      
REMARK 465     THR Q   172                                                      
REMARK 465     GLN Q   173                                                      
REMARK 465     LEU Q   174                                                      
REMARK 465     THR Q   175                                                      
REMARK 465     LEU Q   176                                                      
REMARK 465     ALA Q   177                                                      
REMARK 465     LEU Q   178                                                      
REMARK 465     LYS Q   179                                                      
REMARK 465     GLU Q   180                                                      
REMARK 465     CYS Q   181                                                      
REMARK 465     HIS Q   182                                                      
REMARK 465     ARG Q   183                                                      
REMARK 465     ARG Q   184                                                      
REMARK 465     SER Q   185                                                      
REMARK 465     ASP Q   186                                                      
REMARK 465     GLY Q   187                                                      
REMARK 465     GLY Q   188                                                      
REMARK 465     HIS Q   189                                                      
REMARK 465     THR Q   190                                                      
REMARK 465     VAL Q   191                                                      
REMARK 465     LEU Q   192                                                      
REMARK 465     HIS Q   193                                                      
REMARK 465     ARG Q   194                                                      
REMARK 465     ASP Q   195                                                      
REMARK 465     LEU Q   196                                                      
REMARK 465     LYS Q   197                                                      
REMARK 465     PRO Q   198                                                      
REMARK 465     ALA Q   199                                                      
REMARK 465     ASN Q   200                                                      
REMARK 465     VAL Q   201                                                      
REMARK 465     PHE Q   202                                                      
REMARK 465     LEU Q   203                                                      
REMARK 465     ASP Q   204                                                      
REMARK 465     GLY Q   205                                                      
REMARK 465     LYS Q   206                                                      
REMARK 465     GLN Q   207                                                      
REMARK 465     ASN Q   208                                                      
REMARK 465     VAL Q   209                                                      
REMARK 465     LYS Q   210                                                      
REMARK 465     LEU Q   211                                                      
REMARK 465     GLY Q   212                                                      
REMARK 465     ASP Q   213                                                      
REMARK 465     PHE Q   214                                                      
REMARK 465     GLY Q   215                                                      
REMARK 465     LEU Q   216                                                      
REMARK 465     ALA Q   217                                                      
REMARK 465     ARG Q   218                                                      
REMARK 465     ILE Q   219                                                      
REMARK 465     LEU Q   220                                                      
REMARK 465     ASN Q   221                                                      
REMARK 465     HIS Q   222                                                      
REMARK 465     ASP Q   223                                                      
REMARK 465     THR Q   224                                                      
REMARK 465     SER Q   225                                                      
REMARK 465     PHE Q   226                                                      
REMARK 465     ALA Q   227                                                      
REMARK 465     LYS Q   228                                                      
REMARK 465     THR Q   229                                                      
REMARK 465     PHE Q   230                                                      
REMARK 465     VAL Q   231                                                      
REMARK 465     GLY Q   232                                                      
REMARK 465     THR Q   233                                                      
REMARK 465     PRO Q   234                                                      
REMARK 465     TYR Q   235                                                      
REMARK 465     TYR Q   236                                                      
REMARK 465     MET Q   237                                                      
REMARK 465     SER Q   238                                                      
REMARK 465     PRO Q   239                                                      
REMARK 465     GLU Q   240                                                      
REMARK 465     GLN Q   241                                                      
REMARK 465     MET Q   242                                                      
REMARK 465     ASN Q   243                                                      
REMARK 465     ARG Q   244                                                      
REMARK 465     MET Q   245                                                      
REMARK 465     SER Q   246                                                      
REMARK 465     TYR Q   247                                                      
REMARK 465     ASN Q   248                                                      
REMARK 465     GLU Q   249                                                      
REMARK 465     LYS Q   250                                                      
REMARK 465     SER Q   251                                                      
REMARK 465     ASP Q   252                                                      
REMARK 465     ILE Q   253                                                      
REMARK 465     TRP Q   254                                                      
REMARK 465     SER Q   255                                                      
REMARK 465     LEU Q   256                                                      
REMARK 465     GLY Q   257                                                      
REMARK 465     CYS Q   258                                                      
REMARK 465     LEU Q   259                                                      
REMARK 465     LEU Q   260                                                      
REMARK 465     TYR Q   261                                                      
REMARK 465     GLU Q   262                                                      
REMARK 465     LEU Q   263                                                      
REMARK 465     CYS Q   264                                                      
REMARK 465     ALA Q   265                                                      
REMARK 465     LEU Q   266                                                      
REMARK 465     MET Q   267                                                      
REMARK 465     PRO Q   268                                                      
REMARK 465     PRO Q   269                                                      
REMARK 465     PHE Q   270                                                      
REMARK 465     THR Q   271                                                      
REMARK 465     ALA Q   272                                                      
REMARK 465     PHE Q   273                                                      
REMARK 465     SER Q   274                                                      
REMARK 465     GLN Q   275                                                      
REMARK 465     LYS Q   276                                                      
REMARK 465     GLU Q   277                                                      
REMARK 465     LEU Q   278                                                      
REMARK 465     ALA Q   279                                                      
REMARK 465     GLY Q   280                                                      
REMARK 465     LYS Q   281                                                      
REMARK 465     ILE Q   282                                                      
REMARK 465     ARG Q   283                                                      
REMARK 465     GLU Q   284                                                      
REMARK 465     GLY Q   285                                                      
REMARK 465     LYS Q   286                                                      
REMARK 465     PHE Q   287                                                      
REMARK 465     ARG Q   288                                                      
REMARK 465     ARG Q   289                                                      
REMARK 465     ILE Q   290                                                      
REMARK 465     PRO Q   291                                                      
REMARK 465     TYR Q   292                                                      
REMARK 465     ARG Q   293                                                      
REMARK 465     TYR Q   294                                                      
REMARK 465     SER Q   295                                                      
REMARK 465     ASP Q   296                                                      
REMARK 465     GLU Q   297                                                      
REMARK 465     LEU Q   298                                                      
REMARK 465     ASN Q   299                                                      
REMARK 465     GLU Q   300                                                      
REMARK 465     ILE Q   301                                                      
REMARK 465     ILE Q   302                                                      
REMARK 465     THR Q   303                                                      
REMARK 465     ARG Q   304                                                      
REMARK 465     MET Q   305                                                      
REMARK 465     LEU Q   306                                                      
REMARK 465     ASN Q   307                                                      
REMARK 465     LEU Q   308                                                      
REMARK 465     LYS Q   309                                                      
REMARK 465     ASP Q   310                                                      
REMARK 465     TYR Q   311                                                      
REMARK 465     HIS Q   312                                                      
REMARK 465     ARG Q   313                                                      
REMARK 465     PRO Q   314                                                      
REMARK 465     SER Q   315                                                      
REMARK 465     VAL Q   316                                                      
REMARK 465     GLU Q   317                                                      
REMARK 465     GLU Q   318                                                      
REMARK 465     ILE Q   319                                                      
REMARK 465     LEU Q   320                                                      
REMARK 465     GLU Q   321                                                      
REMARK 465     ASN Q   322                                                      
REMARK 465     PRO Q   323                                                      
REMARK 465     LEU Q   324                                                      
REMARK 465     ILE Q   325                                                      
REMARK 465     ALA Q   326                                                      
REMARK 465     ASP Q   327                                                      
REMARK 465     LEU Q   328                                                      
REMARK 465     VAL Q   329                                                      
REMARK 465     ALA Q   330                                                      
REMARK 465     ASP Q   331                                                      
REMARK 465     GLU Q   332                                                      
REMARK 465     GLN Q   333                                                      
REMARK 465     ARG Q   334                                                      
REMARK 465     ARG Q   335                                                      
REMARK 465     ASN Q   336                                                      
REMARK 465     LEU Q   337                                                      
REMARK 465     GLU Q   338                                                      
REMARK 465     ARG Q   339                                                      
REMARK 465     ARG Q   340                                                      
REMARK 465     GLY Q   341                                                      
REMARK 465     ARG Q   342                                                      
REMARK 465     GLN Q   343                                                      
REMARK 465     LEU Q   344                                                      
REMARK 465     GLY Q   345                                                      
REMARK 465     GLU Q   346                                                      
REMARK 465     PRO Q   347                                                      
REMARK 465     GLU Q   348                                                      
REMARK 465     LYS Q   349                                                      
REMARK 465     SER Q   350                                                      
REMARK 465     GLN Q   351                                                      
REMARK 465     ASP Q   352                                                      
REMARK 465     SER Q   353                                                      
REMARK 465     SER Q   354                                                      
REMARK 465     PRO Q   355                                                      
REMARK 465     VAL Q   356                                                      
REMARK 465     LEU Q   357                                                      
REMARK 465     SER Q   358                                                      
REMARK 465     GLU Q   359                                                      
REMARK 465     LEU Q   360                                                      
REMARK 465     LYS Q   361                                                      
REMARK 465     LEU Q   362                                                      
REMARK 465     LYS Q   363                                                      
REMARK 465     GLU Q   364                                                      
REMARK 465     ILE Q   365                                                      
REMARK 465     GLN Q   366                                                      
REMARK 465     LEU Q   367                                                      
REMARK 465     GLN Q   368                                                      
REMARK 465     GLU Q   369                                                      
REMARK 465     ARG Q   370                                                      
REMARK 465     GLU Q   371                                                      
REMARK 465     ARG Q   372                                                      
REMARK 465     ALA Q   373                                                      
REMARK 465     LEU Q   374                                                      
REMARK 465     LYS Q   375                                                      
REMARK 465     ALA Q   376                                                      
REMARK 465     ARG Q   377                                                      
REMARK 465     GLU Q   378                                                      
REMARK 465     GLU Q   379                                                      
REMARK 465     ARG Q   380                                                      
REMARK 465     LEU Q   381                                                      
REMARK 465     GLU Q   382                                                      
REMARK 465     GLN Q   383                                                      
REMARK 465     LYS Q   384                                                      
REMARK 465     GLU Q   385                                                      
REMARK 465     GLN Q   386                                                      
REMARK 465     GLU Q   387                                                      
REMARK 465     LEU Q   388                                                      
REMARK 465     CYS Q   389                                                      
REMARK 465     VAL Q   390                                                      
REMARK 465     ARG Q   391                                                      
REMARK 465     GLU Q   392                                                      
REMARK 465     ARG Q   393                                                      
REMARK 465     LEU Q   394                                                      
REMARK 465     ALA Q   395                                                      
REMARK 465     GLU Q   396                                                      
REMARK 465     ASP Q   397                                                      
REMARK 465     LYS Q   398                                                      
REMARK 465     LEU Q   399                                                      
REMARK 465     ALA Q   400                                                      
REMARK 465     ARG Q   401                                                      
REMARK 465     ALA Q   402                                                      
REMARK 465     GLU Q   403                                                      
REMARK 465     ASN Q   404                                                      
REMARK 465     LEU Q   405                                                      
REMARK 465     LEU Q   406                                                      
REMARK 465     LYS Q   407                                                      
REMARK 465     ASN Q   408                                                      
REMARK 465     TYR Q   409                                                      
REMARK 465     SER Q   410                                                      
REMARK 465     LEU Q   411                                                      
REMARK 465     LEU Q   412                                                      
REMARK 465     LYS Q   413                                                      
REMARK 465     GLU Q   414                                                      
REMARK 465     ARG Q   415                                                      
REMARK 465     LYS Q   416                                                      
REMARK 465     PHE Q   417                                                      
REMARK 465     LEU Q   418                                                      
REMARK 465     SER Q   419                                                      
REMARK 465     LEU Q   420                                                      
REMARK 465     ALA Q   421                                                      
REMARK 465     SER Q   422                                                      
REMARK 465     ASN Q   423                                                      
REMARK 465     PRO Q   424                                                      
REMARK 465     GLU Q   425                                                      
REMARK 465     LEU Q   426                                                      
REMARK 465     LEU Q   427                                                      
REMARK 465     ASN Q   428                                                      
REMARK 465     LEU Q   429                                                      
REMARK 465     PRO Q   430                                                      
REMARK 465     SER Q   431                                                      
REMARK 465     SER Q   432                                                      
REMARK 465     VAL Q   433                                                      
REMARK 465     ILE Q   434                                                      
REMARK 465     LYS Q   435                                                      
REMARK 465     LYS Q   436                                                      
REMARK 465     LYS Q   437                                                      
REMARK 465     VAL Q   438                                                      
REMARK 465     HIS Q   439                                                      
REMARK 465     PHE Q   440                                                      
REMARK 465     SER Q   441                                                      
REMARK 465     GLY Q   442                                                      
REMARK 465     GLU Q   443                                                      
REMARK 465     SER Q   444                                                      
REMARK 465     LYS Q   445                                                      
REMARK 465     GLU Q   446                                                      
REMARK 465     ASN Q   447                                                      
REMARK 465     ILE Q   448                                                      
REMARK 465     MET Q   449                                                      
REMARK 465     ARG Q   450                                                      
REMARK 465     SER Q   451                                                      
REMARK 465     GLU Q   452                                                      
REMARK 465     ASN Q   453                                                      
REMARK 465     SER Q   454                                                      
REMARK 465     GLU Q   455                                                      
REMARK 465     SER Q   456                                                      
REMARK 465     GLN Q   457                                                      
REMARK 465     LEU Q   458                                                      
REMARK 465     THR Q   459                                                      
REMARK 465     SER Q   460                                                      
REMARK 465     LYS Q   461                                                      
REMARK 465     SER Q   462                                                      
REMARK 465     LYS Q   463                                                      
REMARK 465     CYS Q   464                                                      
REMARK 465     LYS Q   465                                                      
REMARK 465     ASP Q   466                                                      
REMARK 465     LEU Q   467                                                      
REMARK 465     LYS Q   468                                                      
REMARK 465     LYS Q   469                                                      
REMARK 465     ARG Q   470                                                      
REMARK 465     LEU Q   471                                                      
REMARK 465     HIS Q   472                                                      
REMARK 465     ALA Q   473                                                      
REMARK 465     ALA Q   474                                                      
REMARK 465     GLN Q   475                                                      
REMARK 465     LEU Q   476                                                      
REMARK 465     ARG Q   477                                                      
REMARK 465     ALA Q   478                                                      
REMARK 465     GLN Q   479                                                      
REMARK 465     ALA Q   480                                                      
REMARK 465     LEU Q   481                                                      
REMARK 465     SER Q   482                                                      
REMARK 465     ASP Q   483                                                      
REMARK 465     ILE Q   484                                                      
REMARK 465     GLU Q   485                                                      
REMARK 465     LYS Q   486                                                      
REMARK 465     ASN Q   487                                                      
REMARK 465     TYR Q   488                                                      
REMARK 465     GLN Q   489                                                      
REMARK 465     LEU Q   490                                                      
REMARK 465     LYS Q   491                                                      
REMARK 465     SER Q   492                                                      
REMARK 465     ARG Q   493                                                      
REMARK 465     GLN Q   494                                                      
REMARK 465     ILE Q   495                                                      
REMARK 465     LEU Q   496                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     LYS A  71    CG   CD   CE   NZ                                   
REMARK 470     GLU A  82    CG   CD   OE1  OE2                                  
REMARK 470     ILE A  83    CG1  CG2  CD1                                       
REMARK 470     GLN A 109    CG   CD   OE1  NE2                                  
REMARK 470     GLN A 135    CG   CD   OE1  NE2                                  
REMARK 470     ASP A 136    CG   OD1  OD2                                       
REMARK 470     LYS A 137    CG   CD   CE   NZ                                   
REMARK 470     SER A 138    OG                                                  
REMARK 470     GLU A 139    CG   CD   OE1  OE2                                  
REMARK 470     LYS A 140    CG   CD   CE   NZ                                   
REMARK 470     TYR A 142    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     SER A 143    OG                                                  
REMARK 470     SER A 144    OG                                                  
REMARK 470     ASN A 145    CG   OD1  ND2                                       
REMARK 470     GLU A 146    CG   CD   OE1  OE2                                  
REMARK 470     GLU A 148    CG   CD   OE1  OE2                                  
REMARK 470     LYS A 184    CG   CD   CE   NZ                                   
REMARK 470     PRO A 206    CG   CD                                             
REMARK 470     GLU A 219    CG   CD   OE1  OE2                                  
REMARK 470     SER A 234    OG                                                  
REMARK 470     ARG A 235    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP A 241    CG   OD1  OD2                                       
REMARK 470     ASN A 264    CG   OD1  ND2                                       
REMARK 470     GLU A 277    CG   CD   OE1  OE2                                  
REMARK 470     GLU A 278    CG   CD   OE1  OE2                                  
REMARK 470     GLU A 279    CG   CD   OE1  OE2                                  
REMARK 470     ASN A 280    CG   OD1  ND2                                       
REMARK 470     CYS A 408    SG                                                  
REMARK 470     THR A 414    OG1  CG2                                            
REMARK 470     GLU A 415    CG   CD   OE1  OE2                                  
REMARK 470     THR A 416    OG1  CG2                                            
REMARK 470     GLU A 422    CG   CD   OE1  OE2                                  
REMARK 470     LYS A 423    CG   CD   CE   NZ                                   
REMARK 470     ASN A 424    CG   OD1  ND2                                       
REMARK 470     GLU A 447    CG   CD   OE1  OE2                                  
REMARK 470     ASN A 461    CG   OD1  ND2                                       
REMARK 470     ASP A 462    CG   OD1  OD2                                       
REMARK 470     LYS A 463    CG   CD   CE   NZ                                   
REMARK 470     GLN A 465    CG   CD   OE1  NE2                                  
REMARK 470     LYS A 484    CG   CD   CE   NZ                                   
REMARK 470     ASP A 486    CG   OD1  OD2                                       
REMARK 470     GLU A 492    CG   CD   OE1  OE2                                  
REMARK 470     SER A 494    OG                                                  
REMARK 470     LEU A 514    CG   CD1  CD2                                       
REMARK 470     PRO A 515    CG   CD                                             
REMARK 470     GLN A 579    CG   CD   OE1  NE2                                  
REMARK 470     LEU A 580    CG   CD1  CD2                                       
REMARK 470     THR A 582    OG1  CG2                                            
REMARK 470     LYS A 631    CG   CD   CE   NZ                                   
REMARK 470     GLU A 632    CG   CD   OE1  OE2                                  
REMARK 470     PRO A 651    CG   CD                                             
REMARK 470     ASN A 671    CG   OD1  ND2                                       
REMARK 470     THR A 672    OG1  CG2                                            
REMARK 470     ASP A 673    CG   OD1  OD2                                       
REMARK 470     ARG A 674    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LEU A 675    CG   CD1  CD2                                       
REMARK 470     ASP A 704    CG   OD1  OD2                                       
REMARK 470     ASP A 705    CG   OD1  OD2                                       
REMARK 470     ASP A 706    CG   OD1  OD2                                       
REMARK 470     GLU A 708    CG   CD   OE1  OE2                                  
REMARK 470     ASN A 712    CG   OD1  ND2                                       
REMARK 470     ASP A 714    CG   OD1  OD2                                       
REMARK 470     GLN A 717    CG   CD   OE1  NE2                                  
REMARK 470     ASN A 718    CG   OD1  ND2                                       
REMARK 470     GLU A 720    CG   CD   OE1  OE2                                  
REMARK 470     LEU A 723    CG   CD1  CD2                                       
REMARK 470     LEU A 724    CG   CD1  CD2                                       
REMARK 470     ARG A 726    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LEU A 728    CG   CD1  CD2                                       
REMARK 470     LEU A 730    CG   CD1  CD2                                       
REMARK 470     LEU A 747    CG   CD1  CD2                                       
REMARK 470     ASP A 750    CG   OD1  OD2                                       
REMARK 470     ARG A 815    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     THR A 817    OG1  CG2                                            
REMARK 470     ASP A 824    CG   OD1  OD2                                       
REMARK 470     THR A 828    OG1  CG2                                            
REMARK 470     THR A 838    OG1  CG2                                            
REMARK 470     SER A 839    OG                                                  
REMARK 470     GLU A 840    CG   CD   OE1  OE2                                  
REMARK 470     GLU A 855    CG   CD   OE1  OE2                                  
REMARK 470     MET A 857    CG   SD   CE                                        
REMARK 470     ASP A 884    CG   OD1  OD2                                       
REMARK 470     GLU A 885    CG   CD   OE1  OE2                                  
REMARK 470     SER A 886    OG                                                  
REMARK 470     LEU A 887    CG   CD1  CD2                                       
REMARK 470     VAL A 923    CG1  CG2                                            
REMARK 470     SER A 924    OG                                                  
REMARK 470     ASN A 991    CG   OD1  ND2                                       
REMARK 470     LEU A 992    CG   CD1  CD2                                       
REMARK 470     PRO A 993    CG   CD                                             
REMARK 470     GLU A1011    CG   CD   OE1  OE2                                  
REMARK 470     GLU A1012    CG   CD   OE1  OE2                                  
REMARK 470     TYR A1054    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     GLU A1056    CG   CD   OE1  OE2                                  
REMARK 470     ASP A1059    CG   OD1  OD2                                       
REMARK 470     GLU A1098    CG   CD   OE1  OE2                                  
REMARK 470     ASP A1126    CG   OD1  OD2                                       
REMARK 470     ASP A1154    CG   OD1  OD2                                       
REMARK 470     MET A1285    CG   SD   CE                                        
REMARK 470     GLU A1286    CG   CD   OE1  OE2                                  
REMARK 470     CYS A1288    SG                                                  
REMARK 470     ASP A1318    CG   OD1  OD2                                       
REMARK 470     ASP A1356    CG   OD1  OD2                                       
REMARK 470     THR A1357    OG1  CG2                                            
REMARK 470     MET A1393    CG   SD   CE                                        
REMARK 470     GLU A1402    CG   CD   OE1  OE2                                  
REMARK 470     ASP A1418    CG   OD1  OD2                                       
REMARK 470     ASN A1422    CG   OD1  ND2                                       
REMARK 470     ILE A1439    CG1  CG2  CD1                                       
REMARK 470     LEU A1452    CG   CD1  CD2                                       
REMARK 470     GLU A1549    CG   CD   OE1  OE2                                  
REMARK 470     SER A1681    OG                                                  
REMARK 470     LYS A1682    CG   CD   CE   NZ                                   
REMARK 470     GLN A1721    CG   CD   OE1  NE2                                  
REMARK 470     THR A1722    OG1  CG2                                            
REMARK 470     VAL A1723    CG1  CG2                                            
REMARK 470     ASN A1725    CG   OD1  ND2                                       
REMARK 470     ARG A1726    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU A1729    CG   CD   OE1  OE2                                  
REMARK 470     ARG A1731    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASN A1760    CG   OD1  ND2                                       
REMARK 470     LYS A1764    CG   CD   CE   NZ                                   
REMARK 470     ARG A1803    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU A1828    CG   CD   OE1  OE2                                  
REMARK 470     GLN A1831    CG   CD   OE1  NE2                                  
REMARK 470     ASN A1832    CG   OD1  ND2                                       
REMARK 470     HIS A1833    CG   ND1  CD2  CE1  NE2                             
REMARK 470     ARG A1836    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU A1843    CG   CD   OE1  OE2                                  
REMARK 470     VAL A1862    CG1  CG2                                            
REMARK 470     GLN A1875    CG   CD   OE1  NE2                                  
REMARK 470     GLU A1879    CG   CD   OE1  OE2                                  
REMARK 470     LEU A1889    CG   CD1  CD2                                       
REMARK 470     GLN A1898    CG   CD   OE1  NE2                                  
REMARK 470     SER A1908    OG                                                  
REMARK 470     THR A1909    OG1  CG2                                            
REMARK 470     GLU A1913    CG   CD   OE1  OE2                                  
REMARK 470     LYS A1917    CG   CD   CE   NZ                                   
REMARK 470     ARG A1930    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASN B  19    CG   OD1  ND2                                       
REMARK 470     ASP B  20    CG   OD1  OD2                                       
REMARK 470     GLU B  21    CG   CD   OE1  OE2                                  
REMARK 470     ASN B  22    CG   OD1  ND2                                       
REMARK 470     LYS B  38    CG   CD   CE   NZ                                   
REMARK 470     VAL B  39    CG1  CG2                                            
REMARK 470     PRO B  40    CG   CD                                             
REMARK 470     ASP B  42    CG   OD1  OD2                                       
REMARK 470     GLN B  67    CG   CD   OE1  NE2                                  
REMARK 470     GLN B  68    CG   CD   OE1  NE2                                  
REMARK 470     GLN B  70    CG   CD   OE1  NE2                                  
REMARK 470     GLU C  69    CG   CD   OE1  OE2                                  
REMARK 470     CYS C 109    SG                                                  
REMARK 470     LYS C 281    CG   CD   CE   NZ                                   
REMARK 470     ASP C 496    CG   OD1  OD2                                       
REMARK 470     SER C 499    OG                                                  
REMARK 470     CYS C 500    SG                                                  
REMARK 470     ASP D  21    CG   OD1  OD2                                       
REMARK 470     ARG D  22    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     PRO D  23    CG   CD                                             
REMARK 470     CYS D  24    SG                                                  
REMARK 470     LEU D  51    CG   CD1  CD2                                       
REMARK 470     LYS D  56    CG   CD   CE   NZ                                   
REMARK 470     ARG E  52    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LEU E  54    CG   CD1  CD2                                       
REMARK 470     CYS E  55    SG                                                  
REMARK 470     GLN F   5    CG   CD   OE1  NE2                                  
REMARK 470     VAL F  96    CG1  CG2                                            
REMARK 470     THR F 171    OG1  CG2                                            
REMARK 470     GLN F 455    CG   CD   OE1  NE2                                  
REMARK 470     LYS F 456    CG   CD   CE   NZ                                   
REMARK 470     LEU F 462    CG   CD1  CD2                                       
REMARK 470     LYS F 471    CG   CD   CE   NZ                                   
REMARK 470     SER F 478    OG                                                  
REMARK 470     LYS F 482    CG   CD   CE   NZ                                   
REMARK 470     LYS F 557    CG   CD   CE   NZ                                   
REMARK 470     LYS F 588    CG   CD   CE   NZ                                   
REMARK 470     THR F 691    OG1  CG2                                            
REMARK 470     ASN F 693    CG   OD1  ND2                                       
REMARK 470     LYS F 694    CG   CD   CE   NZ                                   
REMARK 470     ILE F 696    CG1  CG2  CD1                                       
REMARK 470     VAL F 697    CG1  CG2                                            
REMARK 470     ILE F 698    CG1  CG2  CD1                                       
REMARK 470     ASP F 699    CG   OD1  OD2                                       
REMARK 470     PRO F 700    CG   CD                                             
REMARK 470     LYS F 701    CG   CD   CE   NZ                                   
REMARK 470     LYS F 706    CG   CD   CE   NZ                                   
REMARK 470     LYS F 720    CG   CD   CE   NZ                                   
REMARK 470     LYS F 735    CG   CD   CE   NZ                                   
REMARK 470     LEU F 738    CG   CD1  CD2                                       
REMARK 470     LYS F 748    CG   CD   CE   NZ                                   
REMARK 470     HIS F 754    CG   ND1  CD2  CE1  NE2                             
REMARK 470     GLN H   5    CG   CD   OE1  NE2                                  
REMARK 470     PHE H 168    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     LYS H 169    CG   CD   CE   NZ                                   
REMARK 470     PHE H 170    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     THR H 171    OG1  CG2                                            
REMARK 470     SER H 172    OG                                                  
REMARK 470     LEU H 173    CG   CD1  CD2                                       
REMARK 470     GLN H 174    CG   CD   OE1  NE2                                  
REMARK 470     ASN H 175    CG   OD1  ND2                                       
REMARK 470     PHE H 452    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ASN H 453    CG   OD1  ND2                                       
REMARK 470     LEU H 454    CG   CD1  CD2                                       
REMARK 470     ASP H 767    CG   OD1  OD2                                       
REMARK 470     GLU I 132    CG   CD   OE1  OE2                                  
REMARK 470     ASP I 133    CG   OD1  OD2                                       
REMARK 470     GLU I 134    CG   CD   OE1  OE2                                  
REMARK 470     LYS I 147    CG   CD   CE   NZ                                   
REMARK 470     THR I 152    OG1  CG2                                            
REMARK 470     SER I 153    OG                                                  
REMARK 470     ILE I 155    CG1  CG2  CD1                                       
REMARK 470     SER I 157    OG                                                  
REMARK 470     GLU I 158    CG   CD   OE1  OE2                                  
REMARK 470     GLU I 159    CG   CD   OE1  OE2                                  
REMARK 470     ASN I 160    CG   OD1  ND2                                       
REMARK 470     SER I 161    OG                                                  
REMARK 470     ASP I 162    CG   OD1  OD2                                       
REMARK 470     GLU I 163    CG   CD   OE1  OE2                                  
REMARK 470     ASP I 170    CG   OD1  OD2                                       
REMARK 470     LYS I 289    CG   CD   CE   NZ                                   
REMARK 470     PHE I 290    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     GLN I 292    CG   CD   OE1  NE2                                  
REMARK 470     GLU I 293    CG   CD   OE1  OE2                                  
REMARK 470     LYS I 294    CG   CD   CE   NZ                                   
REMARK 470     ASN I 295    CG   OD1  ND2                                       
REMARK 470     THR I 296    OG1  CG2                                            
REMARK 470     THR I 297    OG1  CG2                                            
REMARK 470     THR I 298    OG1  CG2                                            
REMARK 470     LYS I 312    CG   CD   CE   NZ                                   
REMARK 470     GLU I 316    CG   CD   OE1  OE2                                  
REMARK 470     LYS I 346    CG   CD   CE   NZ                                   
REMARK 470     GLU I 402    CG   CD   OE1  OE2                                  
REMARK 470     GLU I 430    CG   CD   OE1  OE2                                  
REMARK 470     ASP I 431    CG   OD1  OD2                                       
REMARK 470     HIS I 432    CG   ND1  CD2  CE1  NE2                             
REMARK 470     VAL I 433    CG1  CG2                                            
REMARK 470     GLU I 436    CG   CD   OE1  OE2                                  
REMARK 470     LEU I 437    CG   CD1  CD2                                       
REMARK 470     ASN I 438    CG   OD1  ND2                                       
REMARK 470     LYS I 439    CG   CD   CE   NZ                                   
REMARK 470     GLU I 473    CG   CD   OE1  OE2                                  
REMARK 470     LYS I 480    CG   CD   CE   NZ                                   
REMARK 470     ASP I 481    CG   OD1  OD2                                       
REMARK 470     GLU I 482    CG   CD   OE1  OE2                                  
REMARK 470     ASP I 483    CG   OD1  OD2                                       
REMARK 470     ASP I 484    CG   OD1  OD2                                       
REMARK 470     ASP I 485    CG   OD1  OD2                                       
REMARK 470     LEU I 486    CG   CD1  CD2                                       
REMARK 470     VAL I 487    CG1  CG2                                            
REMARK 470     SER I 488    OG                                                  
REMARK 470     ASN I 495    CG   OD1  ND2                                       
REMARK 470     ASN I 549    CG   OD1  ND2                                       
REMARK 470     GLN I 550    CG   CD   OE1  NE2                                  
REMARK 470     ARG I 567    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG I 659    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU I 660    CG   CD   OE1  OE2                                  
REMARK 470     ARG I 662    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU I 756    CG   CD   OE1  OE2                                  
REMARK 470     ASN J   2    CG   OD1  ND2                                       
REMARK 470     LEU J   3    CG   CD1  CD2                                       
REMARK 470     GLU J   4    CG   CD   OE1  OE2                                  
REMARK 470     SER J 124    OG                                                  
REMARK 470     GLN J 125    CG   CD   OE1  NE2                                  
REMARK 470     SER J 126    OG                                                  
REMARK 470     GLU J 222    CG   CD   OE1  OE2                                  
REMARK 470     GLU J 347    CG   CD   OE1  OE2                                  
REMARK 470     GLU J 524    CG   CD   OE1  OE2                                  
REMARK 470     ASP J 529    CG   OD1  OD2                                       
REMARK 470     SER J 530    OG                                                  
REMARK 470     GLU J 531    CG   CD   OE1  OE2                                  
REMARK 470     ASN K   2    CG   OD1  ND2                                       
REMARK 470     LEU K   3    CG   CD1  CD2                                       
REMARK 470     GLU K   4    CG   CD   OE1  OE2                                  
REMARK 470     ARG K   5    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLN K 228    CG   CD   OE1  NE2                                  
REMARK 470     GLU L 164    CG   CD   OE1  OE2                                  
REMARK 470     SER L 165    OG                                                  
REMARK 470     SER L 166    OG                                                  
REMARK 470     ILE L 167    CG1  CG2  CD1                                       
REMARK 470     LYS L 169    CG   CD   CE   NZ                                   
REMARK 470     PHE L 170    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     PRO L 171    CG   CD                                             
REMARK 470     CYS L 172    SG                                                  
REMARK 470     THR L 173    OG1  CG2                                            
REMARK 470     THR L 174    OG1  CG2                                            
REMARK 470     ILE L 175    CG1  CG2  CD1                                       
REMARK 470     ASP L 176    CG   OD1  OD2                                       
REMARK 470     GLU M  35    CG   CD   OE1  OE2                                  
REMARK 470     GLU M  38    CG   CD   OE1  OE2                                  
REMARK 470     GLU M  67    CG   CD   OE1  OE2                                  
REMARK 470     ARG N  15    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     PRO N  16    CG   CD                                             
REMARK 470     GLN N  18    CG   CD   OE1  NE2                                  
REMARK 470     GLU N  19    CG   CD   OE1  OE2                                  
REMARK 470     LEU N  20    CG   CD1  CD2                                       
REMARK 470     LEU N  21    CG   CD1  CD2                                       
REMARK 470     VAL N  22    CG1  CG2                                            
REMARK 470     TRP N  24    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
REMARK 470     TRP N  24    CZ3  CH2                                            
REMARK 470     ASN N  25    CG   OD1  ND2                                       
REMARK 470     THR N  26    OG1  CG2                                            
REMARK 470     VAL N  27    CG1  CG2                                            
REMARK 470     SER N  28    OG                                                  
REMARK 470     THR N  29    OG1  CG2                                            
REMARK 470     LEU N  31    CG   CD1  CD2                                       
REMARK 470     VAL N  32    CG1  CG2                                            
REMARK 470     PRO N  33    CG   CD                                             
REMARK 470     LYS N  51    CG   CD   CE   NZ                                   
REMARK 470     GLU N  52    CG   CD   OE1  OE2                                  
REMARK 470     GLU N  53    CG   CD   OE1  OE2                                  
REMARK 470     GLU N  54    CG   CD   OE1  OE2                                  
REMARK 470     ASN N  86    CG   OD1  ND2                                       
REMARK 470     GLU N  90    CG   CD   OE1  OE2                                  
REMARK 470     CYS N  98    SG                                                  
REMARK 470     GLU N  99    CG   CD   OE1  OE2                                  
REMARK 470     ASN N 100    CG   OD1  ND2                                       
REMARK 470     SER N 101    OG                                                  
REMARK 470     ASP N 103    CG   OD1  OD2                                       
REMARK 470     GLN N 106    CG   CD   OE1  NE2                                  
REMARK 470     CYS N 107    SG                                                  
REMARK 470     ASP N 113    CG   OD1  OD2                                       
REMARK 470     GLU N 119    CG   CD   OE1  OE2                                  
REMARK 470     GLU N 130    CG   CD   OE1  OE2                                  
REMARK 470     GLU N 133    CG   CD   OE1  OE2                                  
REMARK 470     LYS N 134    CG   CD   CE   NZ                                   
REMARK 470     MET N 142    CG   SD   CE                                        
REMARK 470     THR N 144    OG1  CG2                                            
REMARK 470     GLN N 147    CG   CD   OE1  NE2                                  
REMARK 470     ARG N 150    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     SER N 164    OG                                                  
REMARK 470     THR N 165    OG1  CG2                                            
REMARK 470     GLU N 254    CG   CD   OE1  OE2                                  
REMARK 470     ARG N 276    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG N 278    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU N 280    CG   CD   OE1  OE2                                  
REMARK 470     TYR N 281    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     GLU N 282    CG   CD   OE1  OE2                                  
REMARK 470     GLU N 294    CG   CD   OE1  OE2                                  
REMARK 470     ASN N 319    CG   OD1  ND2                                       
REMARK 470     ASP N 353    CG   OD1  OD2                                       
REMARK 470     THR N 443    CG2                                                 
REMARK 470     GLU N 476    CG   CD   OE1  OE2                                  
REMARK 470     GLU N 478    CG   CD   OE1  OE2                                  
REMARK 470     ASP N 479    CG   OD1  OD2                                       
REMARK 470     ASP N 483    CG   OD1  OD2                                       
REMARK 470     ASP N 486    CG   OD1  OD2                                       
REMARK 470     SER N 499    OG                                                  
REMARK 470     LYS N 747    CG   CD   CE   NZ                                   
REMARK 470     GLU N 749    CG   CD   OE1  OE2                                  
REMARK 470     GLU N 750    CG   CD   OE1  OE2                                  
REMARK 470     LEU N 751    CG   CD1  CD2                                       
REMARK 470     GLU N 789    CG   CD   OE1  OE2                                  
REMARK 470     ARG N 804    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     THR O  47    OG1  CG2                                            
REMARK 470     GLU O  49    CG   CD   OE1  OE2                                  
REMARK 470     VAL O  52    CG1  CG2                                            
REMARK 470     THR O 122    OG1  CG2                                            
REMARK 470     GLU O 123    CG   CD   OE1  OE2                                  
REMARK 470     LYS O 167    CG   CD   CE   NZ                                   
REMARK 470     LYS O 229    CG   CD   CE   NZ                                   
REMARK 470     LYS O 397    CG   CD   CE   NZ                                   
REMARK 470     ASP O 400    CG   OD1  OD2                                       
REMARK 470     GLU O 452    CG   CD   OE1  OE2                                  
REMARK 470     VAL O 458    CG1  CG2                                            
REMARK 470     GLN O 742    CG   CD   OE1  NE2                                  
REMARK 470     GLU O 743    CG   CD   OE1  OE2                                  
REMARK 470     LEU O 744    CG   CD1  CD2                                       
REMARK 470     SER O 746    OG                                                  
REMARK 470     HIS O 747    CG   ND1  CD2  CE1  NE2                             
REMARK 470     VAL O 749    CG1  CG2                                            
REMARK 470     HIS O 754    CG   ND1  CD2  CE1  NE2                             
REMARK 470     LEU O 755    CG   CD1  CD2                                       
REMARK 470     GLU P  69    CG   CD   OE1  OE2                                  
REMARK 470     CYS P 109    SG                                                  
REMARK 470     LYS P 161    CG   CD   CE   NZ                                   
REMARK 470     LYS P 281    CG   CD   CE   NZ                                   
REMARK 470     ASP P 496    CG   OD1  OD2                                       
REMARK 470     ILE P 497    CD1                                                 
REMARK 470     SER P 499    OG                                                  
REMARK 470     CYS P 500    SG                                                  
REMARK 470     LEU T   7    CG   CD1  CD2                                       
REMARK 470     LYS W  24    CG   CD   CE   NZ                                   
REMARK 470     ASP W  25    CG   OD1  OD2                                       
REMARK 470     LEU W  26    CG   CD1  CD2                                       
REMARK 470     LYS X 215    CG   CD   CE   NZ                                   
REMARK 470     GLU X 218    CG   CD   OE1  OE2                                  
REMARK 470     MET X 224    CG   SD   CE                                        
REMARK 470     ASN X 225    CG   OD1  ND2                                       
REMARK 470     GLN X 228    CG   CD   OE1  NE2                                  
REMARK 470     ARG X 317    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU X 318    CG   CD   OE1  OE2                                  
REMARK 470     ASN X 440    CG   OD1  ND2                                       
REMARK 470     ARG X 472    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS Y 215    CG   CD   CE   NZ                                   
REMARK 470     GLU Y 218    CG   CD   OE1  OE2                                  
REMARK 470     MET Y 224    CG   SD   CE                                        
REMARK 470     ASN Y 225    CG   OD1  ND2                                       
REMARK 470     GLN Y 228    CG   CD   OE1  NE2                                  
REMARK 470     ARG Y 317    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU Y 318    CG   CD   OE1  OE2                                  
REMARK 470     ASN Y 440    CG   OD1  ND2                                       
REMARK 470     ARG Y 472    CG   CD   NE   CZ   NH1  NH2                        
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   NH1  ARG P   400     O    MET Q   498              1.62            
REMARK 500   NH1  ARG P   400     CB   ARG Q   499              1.91            
REMARK 500   NH2  ARG P   277     CE   MET Q   498              1.92            
REMARK 500   O    ASP A   809     OG1  THR A  1808              1.96            
REMARK 500   OD1  ASP X    85     OH   TYR X   100              2.02            
REMARK 500   OG1  THR A  1626     OG1  THR A  1628              2.04            
REMARK 500   O    ASP N   500     OG   SER N   503              2.05            
REMARK 500   O    PRO Y   302     NH2  ARG Y   330              2.05            
REMARK 500   O    ALA O   391     NH1  ARG O   615              2.06            
REMARK 500   OH   TYR K   309     OD1  ASP M    59              2.07            
REMARK 500   O    ARG N   431     OG1  THR N   434              2.07            
REMARK 500   OG1  THR Y   248     OD2  ASP Y   250              2.07            
REMARK 500   NH1  ARG P   400     C    MET Q   498              2.08            
REMARK 500   NE2  HIS C   347     OE1  GLU C   377              2.08            
REMARK 500   OE1  GLU O   326     NH2  ARG O   329              2.08            
REMARK 500   O    LEU A   710     OG   SER A   713              2.08            
REMARK 500   O    VAL I   171     OH   TYR I   190              2.08            
REMARK 500   O    HIS O   254     OG   SER O   257              2.09            
REMARK 500   O    SER H   102     N    ASP H   105              2.09            
REMARK 500   O    TYR O   721     N    GLY O   725              2.09            
REMARK 500   O    THR L    73     OG1  THR L   160              2.09            
REMARK 500   O    ILE I   544     OG   SER I   547              2.09            
REMARK 500   OD2  ASP X   204     OG   SER Y    51              2.10            
REMARK 500   NH2  ARG H   526     O    ASN H   530              2.10            
REMARK 500   OH   TYR A  1463     OD1  ASN A  1511              2.10            
REMARK 500   O    VAL I   124     OG   SER I   127              2.10            
REMARK 500   O    ILE I   337     OG   SER I   340              2.10            
REMARK 500   O    TYR J   378     OG1  THR J   381              2.11            
REMARK 500   NZ   LYS H   660     OE2  GLU K   496              2.11            
REMARK 500   OE1  GLU I   186     OH   TYR I   188              2.11            
REMARK 500   OE2  GLU J   388     OG   SER J   392              2.11            
REMARK 500   O    CYS C   536     OG1  THR C   542              2.12            
REMARK 500   OG   SER O   147     OH   TYR P   353              2.12            
REMARK 500   O    ASN L    49     OG1  THR L    52              2.13            
REMARK 500   O    ALA H   132     OG   SER H   135              2.13            
REMARK 500   NH1  ARG N   334     OG1  THR N   368              2.13            
REMARK 500   O    GLU I   388     OG1  THR I   391              2.13            
REMARK 500   OG   SER A   212     OG1  THR A   221              2.13            
REMARK 500   O    LEU Y   207     OG   SER Y   211              2.13            
REMARK 500   OD1  ASP N   411     OG   SER N   413              2.13            
REMARK 500   O    TYR P   264     OG   SER P   267              2.13            
REMARK 500   OG   SER A   134     N    ASP A   136              2.13            
REMARK 500   O    SER A  1573     NH1  ARG A  1617              2.13            
REMARK 500   OG   SER A  1133     ND2  ASN A  1170              2.13            
REMARK 500   OD1  ASN H   702     N    CYS H   705              2.14            
REMARK 500   OG   SER I   505     OE2  GLU O   488              2.14            
REMARK 500   O    PRO O   498     OG   SER O   501              2.14            
REMARK 500   O    LEU X   446     OG1  THR X   449              2.14            
REMARK 500   O    LEU A  1089     OG   SER A  1091              2.14            
REMARK 500   OE2  GLU H   537     OH   TYR H   600              2.14            
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS      99 CLOSE CONTACTS                                
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500    CYS A 129   CA  -  CB  -  SG  ANGL. DEV. =   7.8 DEGREES          
REMARK 500    LEU H 148   CA  -  CB  -  CG  ANGL. DEV. =  14.6 DEGREES          
REMARK 500    PRO I 490   C   -  N   -  CA  ANGL. DEV. =  14.8 DEGREES          
REMARK 500    PRO I 490   C   -  N   -  CD  ANGL. DEV. = -13.6 DEGREES          
REMARK 500    PRO L 171   C   -  N   -  CA  ANGL. DEV. =  15.8 DEGREES          
REMARK 500    LEU N 122   C   -  N   -  CA  ANGL. DEV. =  16.3 DEGREES          
REMARK 500    LEU Y 413   CA  -  CB  -  CG  ANGL. DEV. =  14.0 DEGREES          
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    LYS A  78      152.69    -45.17                                   
REMARK 500    ILE A  83      -18.93    -48.46                                   
REMARK 500    ASP A  86       33.04    -92.77                                   
REMARK 500    ASP A  88       17.69     50.30                                   
REMARK 500    ALA A  96       32.01   -142.58                                   
REMARK 500    ASP A 120       -3.09     82.83                                   
REMARK 500    GLN A 124      -62.35    -93.07                                   
REMARK 500    GLN A 125      -56.01   -122.52                                   
REMARK 500    ALA A 126       69.84     60.65                                   
REMARK 500    CYS A 129       89.64   -151.40                                   
REMARK 500    LYS A 184      155.29    -48.83                                   
REMARK 500    TYR A 185       -9.02     66.88                                   
REMARK 500    PRO A 216      -15.23    -49.67                                   
REMARK 500    ARG A 235       69.15     61.28                                   
REMARK 500    SER A 267      122.26   -170.05                                   
REMARK 500    LYS A 275       73.95     49.81                                   
REMARK 500    SER A 276      -36.31    -33.25                                   
REMARK 500    LEU A 407       64.66     62.46                                   
REMARK 500    THR A 414      161.01    173.01                                   
REMARK 500    ASN A 424     -174.28    178.10                                   
REMARK 500    SER A 425      148.56   -172.67                                   
REMARK 500    PHE A 431      144.18   -173.28                                   
REMARK 500    LEU A 450       -7.50     74.66                                   
REMARK 500    GLN A 458      143.61   -173.63                                   
REMARK 500    THR A 487     -167.28   -119.12                                   
REMARK 500    ARG A 588     -172.09   -171.63                                   
REMARK 500    HIS A 592       57.66     35.71                                   
REMARK 500    ASN A 593        1.74     83.14                                   
REMARK 500    SER A 615      111.04   -165.30                                   
REMARK 500    PRO A 648       49.02    -67.87                                   
REMARK 500    SER A 652       -0.32     70.70                                   
REMARK 500    TYR A 653       19.42     50.37                                   
REMARK 500    MET A 668       53.91    -98.70                                   
REMARK 500    THR A 777      -12.29     72.21                                   
REMARK 500    THR A 812       45.99    -84.11                                   
REMARK 500    LEU A 813      -30.30   -136.92                                   
REMARK 500    THR A 817       61.61     67.70                                   
REMARK 500    THR A 822      -74.90    -62.80                                   
REMARK 500    THR A 828       -0.18     62.73                                   
REMARK 500    SER A 839       -5.47     66.94                                   
REMARK 500    TYR A 860       88.45     56.25                                   
REMARK 500    PRO A 861       83.73    -66.38                                   
REMARK 500    CYS A 867       67.76    -68.52                                   
REMARK 500    ARG A 898     -175.28    -68.57                                   
REMARK 500    LEU A 926       -5.71     65.18                                   
REMARK 500    SER A 968     -162.70   -171.07                                   
REMARK 500    ASP A 969      109.74    -47.01                                   
REMARK 500    MET A1016        0.19     59.36                                   
REMARK 500    SER A1029     -166.25    -79.40                                   
REMARK 500    HIS A1045       75.45     50.17                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     349 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS                                         
REMARK 500                                                                      
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH          
REMARK 500 CIS AND TRANS CONFORMATION.  CIS BONDS, IF ANY, ARE LISTED           
REMARK 500 ON CISPEP RECORDS.  TRANS IS DEFINED AS 180 +/- 30 AND               
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.                                  
REMARK 500                                 MODEL     OMEGA                      
REMARK 500 TRP A  128     CYS A  129                 -149.74                    
REMARK 500 LYS A  140     ALA A  141                 -149.01                    
REMARK 500 ASN A  424     SER A  425                  149.12                    
REMARK 500 ASP A  824     PRO A  825                  142.54                    
REMARK 500 GLU A  855     GLY A  856                  146.90                    
REMARK 500 GLY A  856     MET A  857                 -144.99                    
REMARK 500 GLU A 1455     THR A 1456                   34.67                    
REMARK 500 ASP A 1679     LEU A 1680                  148.73                    
REMARK 500 TRP B   14     LEU B   15                  -48.65                    
REMARK 500 LEU B   15     TRP B   16                 -140.44                    
REMARK 500 VAL F   96     PHE F   97                  -40.48                    
REMARK 500 LYS H  101     SER H  102                  145.24                    
REMARK 500 THR I  119     VAL I  120                  149.51                    
REMARK 500 VAL I  120     GLU I  121                  142.60                    
REMARK 500 PRO I  489     PRO I  490                   32.27                    
REMARK 500 PHE I  514     PRO I  515                  142.15                    
REMARK 500 GLN K   87     GLN K   88                  145.76                    
REMARK 500 LEU N  122     ASP N  123                  147.48                    
REMARK 500 GLU N  432     ASP N  433                  148.81                    
REMARK 500 ASP N  433     THR N  434                  122.84                    
REMARK 500 GLN N  530     PHE N  531                  136.23                    
REMARK 500 PHE N  531     SER N  532                  149.01                    
REMARK 500 SER N  534     PRO N  535                 -146.05                    
REMARK 500 GLY N  703     VAL N  704                   71.55                    
REMARK 500 SER O  355     ASP O  356                 -146.81                    
REMARK 500 ASP O  356     SER O  357                  -46.65                    
REMARK 500 SER O  357     TYR O  358                  143.58                    
REMARK 500 ASN O  396     LYS O  397                 -141.02                    
REMARK 500 LYS O  397     LEU O  398                  142.76                    
REMARK 500 LEU O  398     MET O  399                  147.68                    
REMARK 500 ALA O  656     ILE O  657                  121.60                    
REMARK 500 ALA T   10     ALA T   11                  144.99                    
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 620                                                                      
REMARK 620 METAL COORDINATION                                                   
REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE):                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              ZN B 101  ZN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS B  23   SG                                                     
REMARK 620 2 MET B  28   O   119.4                                              
REMARK 620 3 HIS B  56   ND1  87.7 118.6                                        
REMARK 620 N                    1     2                                         
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              ZN B 103  ZN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS B  37   N                                                      
REMARK 620 2 CYS B  37   O    78.5                                              
REMARK 620 N                    1                                               
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              ZN B 102  ZN                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 CYS B  51   SG                                                     
REMARK 620 2 HIS B  53   ND1 130.6                                              
REMARK 620 3 CYS B  76   SG  119.6  96.3                                        
REMARK 620 N                    1     2                                         
REMARK 800                                                                      
REMARK 800 SITE                                                                 
REMARK 800 SITE_IDENTIFIER: AC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN B 101                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN B 102                  
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC3                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN B 103                  
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: EMD-10518   RELATED DB: EMDB                             
REMARK 900 CRYO-EM STRUCTURE OF THE ANAPHASE-PROMOTING COMPLEX/CYCLOSOME, IN    
REMARK 900 COMPLEX WITH THE NEK2A SUBSTRATE AT 3.9 ANGSTROM RESOLUTION          
DBREF  6TM5 A    1  1944  UNP    Q9H1A4   APC1_HUMAN       1   1944             
DBREF  6TM5 B    1    84  UNP    Q9NYG5   APC11_HUMAN      1     84             
DBREF  6TM5 C    1   597  UNP    Q9UJX2   CDC23_HUMAN      1    597             
DBREF  6TM5 D    1   121  UNP    P60006   APC15_HUMAN      1    121             
DBREF  6TM5 E    1   110  UNP    Q96DE5   APC16_HUMAN      1    110             
DBREF  6TM5 F    1   824  UNP    P30260   CDC27_HUMAN      1    824             
DBREF  6TM5 G    1    85  UNP    Q8NHZ8   CDC26_HUMAN      1     85             
DBREF  6TM5 H    1   824  UNP    P30260   CDC27_HUMAN      1    824             
DBREF  6TM5 I    1   808  UNP    Q9UJX5   APC4_HUMAN       1    808             
DBREF  6TM5 J    1   620  UNP    Q13042   CDC16_HUMAN      1    620             
DBREF  6TM5 K    1   620  UNP    Q13042   CDC16_HUMAN      1    620             
DBREF  6TM5 L    1   184  UNP    Q9UM13   APC10_HUMAN      1    185             
DBREF  6TM5 M    1    74  UNP    Q9BS18   APC13_HUMAN      1     74             
DBREF  6TM5 N    1   822  UNP    Q9UJX6   ANC2_HUMAN       1    822             
DBREF  6TM5 O    1   755  UNP    Q9UJX4   APC5_HUMAN       1    755             
DBREF  6TM5 P    1   597  UNP    Q9UJX2   CDC23_HUMAN      1    597             
DBREF  6TM5 T    1    15  PDB    6TM5     6TM5             1     15             
DBREF  6TM5 W    1    85  UNP    Q8NHZ8   CDC26_HUMAN      1     85             
DBREF  6TM5 X    1   599  UNP    Q9UJX3   APC7_HUMAN       1    599             
DBREF  6TM5 Y    1   599  UNP    Q9UJX3   APC7_HUMAN       1    599             
DBREF  6TM5 S   55   499  UNP    P51955   NEK2_HUMAN       1    445             
DBREF  6TM5 Q   55   499  UNP    P51955   NEK2_HUMAN       1    445             
SEQADV 6TM5 PHE A  356  UNP  Q9H1A4    PRO   356 CONFLICT                       
SEQADV 6TM5 ALA S  449  UNP  P51955    MET   395 CONFLICT                       
SEQRES   1 A 1944  MET SER ASN PHE TYR GLU GLU ARG THR THR MET ILE ALA          
SEQRES   2 A 1944  ALA ARG ASP LEU GLN GLU PHE VAL PRO PHE GLY ARG ASP          
SEQRES   3 A 1944  HIS CYS LYS HIS HIS PRO ASN ALA LEU ASN LEU GLN LEU          
SEQRES   4 A 1944  ARG GLN LEU GLN PRO ALA SER GLU LEU TRP SER SER ASP          
SEQRES   5 A 1944  GLY ALA ALA GLY LEU VAL GLY SER LEU GLN GLU VAL THR          
SEQRES   6 A 1944  ILE HIS GLU LYS GLN LYS GLU SER TRP GLN LEU ARG LYS          
SEQRES   7 A 1944  GLY VAL SER GLU ILE GLY GLU ASP VAL ASP TYR ASP GLU          
SEQRES   8 A 1944  GLU LEU TYR VAL ALA GLY ASN MET VAL ILE TRP SER LYS          
SEQRES   9 A 1944  GLY SER LYS SER GLN ALA LEU ALA VAL TYR LYS ALA PHE          
SEQRES  10 A 1944  THR VAL ASP SER PRO VAL GLN GLN ALA LEU TRP CYS ASP          
SEQRES  11 A 1944  PHE ILE ILE SER GLN ASP LYS SER GLU LYS ALA TYR SER          
SEQRES  12 A 1944  SER ASN GLU VAL GLU LYS CYS ILE CYS ILE LEU GLN SER          
SEQRES  13 A 1944  SER CYS ILE ASN MET HIS SER ILE GLU GLY LYS ASP TYR          
SEQRES  14 A 1944  ILE ALA SER LEU PRO PHE GLN VAL ALA ASN VAL TRP PRO          
SEQRES  15 A 1944  THR LYS TYR GLY LEU LEU PHE GLU ARG SER ALA SER SER          
SEQRES  16 A 1944  HIS GLU VAL PRO PRO GLY SER PRO ARG GLU PRO LEU PRO          
SEQRES  17 A 1944  THR MET PHE SER MET LEU HIS PRO LEU ASP GLU ILE THR          
SEQRES  18 A 1944  PRO LEU VAL CYS LYS SER GLY SER LEU PHE GLY SER SER          
SEQRES  19 A 1944  ARG VAL GLN TYR VAL VAL ASP HIS ALA MET LYS ILE VAL          
SEQRES  20 A 1944  PHE LEU ASN THR ASP PRO SER ILE VAL MET THR TYR ASP          
SEQRES  21 A 1944  ALA VAL GLN ASN VAL HIS SER VAL TRP THR LEU ARG ARG          
SEQRES  22 A 1944  VAL LYS SER GLU GLU GLU ASN VAL VAL LEU LYS PHE SER          
SEQRES  23 A 1944  GLU GLN GLY GLY THR PRO GLN ASN VAL ALA THR SER SER          
SEQRES  24 A 1944  SER LEU THR ALA HIS LEU ARG SER LEU SER LYS GLY ASP          
SEQRES  25 A 1944  SER PRO VAL THR SER PRO PHE GLN ASN TYR SER SER ILE          
SEQRES  26 A 1944  HIS SER GLN SER ARG SER THR SER SER PRO SER LEU HIS          
SEQRES  27 A 1944  SER ARG SER PRO SER ILE SER ASN MET ALA ALA LEU SER          
SEQRES  28 A 1944  ARG ALA HIS SER PHE ALA LEU GLY VAL HIS SER PHE SER          
SEQRES  29 A 1944  GLY VAL GLN ARG PHE ASN ILE SER SER HIS ASN GLN SER          
SEQRES  30 A 1944  PRO LYS ARG HIS SER ILE SER HIS SER PRO ASN SER ASN          
SEQRES  31 A 1944  SER ASN GLY SER PHE LEU ALA PRO GLU THR GLU PRO ILE          
SEQRES  32 A 1944  VAL PRO GLU LEU CYS ILE ASP HIS LEU TRP THR GLU THR          
SEQRES  33 A 1944  ILE THR ASN ILE ARG GLU LYS ASN SER GLN ALA SER LYS          
SEQRES  34 A 1944  VAL PHE ILE THR SER ASP LEU CYS GLY GLN LYS PHE LEU          
SEQRES  35 A 1944  CYS PHE LEU VAL GLU SER GLN LEU GLN LEU ARG CYS VAL          
SEQRES  36 A 1944  LYS PHE GLN GLU SER ASN ASP LYS THR GLN LEU ILE PHE          
SEQRES  37 A 1944  GLY SER VAL THR ASN ILE PRO ALA LYS ASP ALA ALA PRO          
SEQRES  38 A 1944  VAL GLU LYS ILE ASP THR MET LEU VAL LEU GLU GLY SER          
SEQRES  39 A 1944  GLY ASN LEU VAL LEU TYR THR GLY VAL VAL ARG VAL GLY          
SEQRES  40 A 1944  LYS VAL PHE ILE PRO GLY LEU PRO ALA PRO SER LEU THR          
SEQRES  41 A 1944  MET SER ASN THR MET PRO ARG PRO SER THR PRO LEU ASP          
SEQRES  42 A 1944  GLY VAL SER THR PRO LYS PRO LEU SER LYS LEU LEU GLY          
SEQRES  43 A 1944  SER LEU ASP GLU VAL VAL LEU LEU SER PRO VAL PRO GLU          
SEQRES  44 A 1944  LEU ARG ASP SER SER LYS LEU HIS ASP SER LEU TYR ASN          
SEQRES  45 A 1944  GLU ASP CYS THR PHE GLN GLN LEU GLY THR TYR ILE HIS          
SEQRES  46 A 1944  SER ILE ARG ASP PRO VAL HIS ASN ARG VAL THR LEU GLU          
SEQRES  47 A 1944  LEU SER ASN GLY SER MET VAL ARG ILE THR ILE PRO GLU          
SEQRES  48 A 1944  ILE ALA THR SER GLU LEU VAL GLN THR CYS LEU GLN ALA          
SEQRES  49 A 1944  ILE LYS PHE ILE LEU PRO LYS GLU ILE ALA VAL GLN MET          
SEQRES  50 A 1944  LEU VAL LYS TRP TYR ASN VAL HIS SER ALA PRO GLY GLY          
SEQRES  51 A 1944  PRO SER TYR HIS SER GLU TRP ASN LEU PHE VAL THR CYS          
SEQRES  52 A 1944  LEU MET ASN MET MET GLY TYR ASN THR ASP ARG LEU ALA          
SEQRES  53 A 1944  TRP THR ARG ASN PHE ASP PHE GLU GLY SER LEU SER PRO          
SEQRES  54 A 1944  VAL ILE ALA PRO LYS LYS ALA ARG PRO SER GLU THR GLY          
SEQRES  55 A 1944  SER ASP ASP ASP TRP GLU TYR LEU LEU ASN SER ASP TYR          
SEQRES  56 A 1944  HIS GLN ASN VAL GLU SER HIS LEU LEU ASN ARG SER LEU          
SEQRES  57 A 1944  CYS LEU SER PRO SER GLU ALA SER GLN MET LYS ASP GLU          
SEQRES  58 A 1944  ASP PHE SER GLN ASN LEU SER LEU ASP SER SER THR LEU          
SEQRES  59 A 1944  LEU PHE THR HIS ILE PRO ALA ILE PHE PHE VAL LEU HIS          
SEQRES  60 A 1944  LEU VAL TYR GLU GLU LEU LYS LEU ASN THR LEU MET GLY          
SEQRES  61 A 1944  GLU GLY ILE CYS SER LEU VAL GLU LEU LEU VAL GLN LEU          
SEQRES  62 A 1944  ALA ARG ASP LEU LYS LEU GLY PRO TYR VAL ASP HIS TYR          
SEQRES  63 A 1944  TYR ARG ASP TYR PRO THR LEU VAL ARG THR THR GLY GLN          
SEQRES  64 A 1944  VAL CYS THR ILE ASP PRO GLY GLN THR GLY PHE MET HIS          
SEQRES  65 A 1944  HIS PRO SER PHE PHE THR SER GLU PRO PRO SER ILE TYR          
SEQRES  66 A 1944  GLN TRP VAL SER SER CYS LEU LYS GLY GLU GLY MET PRO          
SEQRES  67 A 1944  PRO TYR PRO TYR LEU PRO GLY ILE CYS GLU ARG SER ARG          
SEQRES  68 A 1944  LEU VAL VAL LEU SER ILE ALA LEU TYR ILE LEU GLY ASP          
SEQRES  69 A 1944  GLU SER LEU VAL SER ASP GLU SER SER GLN TYR LEU THR          
SEQRES  70 A 1944  ARG ILE THR ILE ALA PRO GLN LYS LEU GLN VAL GLU GLN          
SEQRES  71 A 1944  GLU GLU ASN ARG PHE SER PHE ARG HIS SER THR SER VAL          
SEQRES  72 A 1944  SER SER LEU ALA GLU ARG LEU VAL VAL TRP MET THR ASN          
SEQRES  73 A 1944  VAL GLY PHE THR LEU ARG ASP LEU GLU THR LEU PRO PHE          
SEQRES  74 A 1944  GLY ILE ALA LEU PRO ILE ARG ASP ALA ILE TYR HIS CYS          
SEQRES  75 A 1944  ARG GLU GLN PRO ALA SER ASP TRP PRO GLU ALA VAL CYS          
SEQRES  76 A 1944  LEU LEU ILE GLY ARG GLN ASP LEU SER LYS GLN ALA CYS          
SEQRES  77 A 1944  GLU GLY ASN LEU PRO LYS GLY LYS SER VAL LEU SER SER          
SEQRES  78 A 1944  ASP VAL PRO SER GLY THR GLU THR GLU GLU GLU ASP ASP          
SEQRES  79 A 1944  GLY MET ASN ASP MET ASN HIS GLU VAL MET SER LEU ILE          
SEQRES  80 A 1944  TRP SER GLU ASP LEU ARG VAL GLN ASP VAL ARG ARG LEU          
SEQRES  81 A 1944  LEU GLN SER ALA HIS PRO VAL ARG VAL ASN VAL VAL GLN          
SEQRES  82 A 1944  TYR PRO GLU LEU SER ASP HIS GLU PHE ILE GLU GLU LYS          
SEQRES  83 A 1944  GLU ASN ARG LEU LEU GLN LEU CYS GLN ARG THR MET ALA          
SEQRES  84 A 1944  LEU PRO VAL GLY ARG GLY MET PHE THR LEU PHE SER TYR          
SEQRES  85 A 1944  HIS PRO VAL PRO THR GLU PRO LEU PRO ILE PRO LYS LEU          
SEQRES  86 A 1944  ASN LEU THR GLY ARG ALA PRO PRO ARG ASN THR THR VAL          
SEQRES  87 A 1944  ASP LEU ASN SER GLY ASN ILE ASP VAL PRO PRO ASN MET          
SEQRES  88 A 1944  THR SER TRP ALA SER PHE HIS ASN GLY VAL ALA ALA GLY          
SEQRES  89 A 1944  LEU LYS ILE ALA PRO ALA SER GLN ILE ASP SER ALA TRP          
SEQRES  90 A 1944  ILE VAL TYR ASN LYS PRO LYS HIS ALA GLU LEU ALA ASN          
SEQRES  91 A 1944  GLU TYR ALA GLY PHE LEU MET ALA LEU GLY LEU ASN GLY          
SEQRES  92 A 1944  HIS LEU THR LYS LEU ALA THR LEU ASN ILE HIS ASP TYR          
SEQRES  93 A 1944  LEU THR LYS GLY HIS GLU MET THR SER ILE GLY LEU LEU          
SEQRES  94 A 1944  LEU GLY VAL SER ALA ALA LYS LEU GLY THR MET ASP MET          
SEQRES  95 A 1944  SER ILE THR ARG LEU LEU SER ILE HIS ILE PRO ALA LEU          
SEQRES  96 A 1944  LEU PRO PRO THR SER THR GLU LEU ASP VAL PRO HIS ASN          
SEQRES  97 A 1944  VAL GLN VAL ALA ALA VAL VAL GLY ILE GLY LEU VAL TYR          
SEQRES  98 A 1944  GLN GLY THR ALA HIS ARG HIS THR ALA GLU VAL LEU LEU          
SEQRES  99 A 1944  ALA GLU ILE GLY ARG PRO PRO GLY PRO GLU MET GLU TYR          
SEQRES 100 A 1944  CYS THR ASP ARG GLU SER TYR SER LEU ALA ALA GLY LEU          
SEQRES 101 A 1944  ALA LEU GLY MET VAL CYS LEU GLY HIS GLY SER ASN LEU          
SEQRES 102 A 1944  ILE GLY MET SER ASP LEU ASN VAL PRO GLU GLN LEU TYR          
SEQRES 103 A 1944  GLN TYR MET VAL GLY GLY HIS ARG ARG PHE GLN THR GLY          
SEQRES 104 A 1944  MET HIS ARG GLU LYS HIS LYS SER PRO SER TYR GLN ILE          
SEQRES 105 A 1944  LYS GLU GLY ASP THR ILE ASN VAL ASP VAL THR CYS PRO          
SEQRES 106 A 1944  GLY ALA THR LEU ALA LEU ALA MET ILE TYR LEU LYS THR          
SEQRES 107 A 1944  ASN ASN ARG SER ILE ALA ASP TRP LEU ARG ALA PRO ASP          
SEQRES 108 A 1944  THR MET TYR LEU LEU ASP PHE VAL LYS PRO GLU PHE LEU          
SEQRES 109 A 1944  LEU LEU ARG THR LEU ALA ARG CYS LEU ILE LEU TRP ASP          
SEQRES 110 A 1944  ASP ILE LEU PRO ASN SER LYS TRP VAL ASP SER ASN VAL          
SEQRES 111 A 1944  PRO GLN ILE ILE ARG GLU ASN SER ILE SER LEU SER GLU          
SEQRES 112 A 1944  ILE GLU LEU PRO CYS SER GLU ASP LEU ASN LEU GLU THR          
SEQRES 113 A 1944  LEU SER GLN ALA HIS VAL TYR ILE ILE ALA GLY ALA CYS          
SEQRES 114 A 1944  LEU SER LEU GLY PHE ARG PHE ALA GLY SER GLU ASN LEU          
SEQRES 115 A 1944  SER ALA PHE ASN CYS LEU HIS LYS PHE ALA LYS ASP PHE          
SEQRES 116 A 1944  MET THR TYR LEU SER ALA PRO ASN ALA SER VAL THR GLY          
SEQRES 117 A 1944  PRO HIS ASN LEU GLU THR CYS LEU SER VAL VAL LEU LEU          
SEQRES 118 A 1944  SER LEU ALA MET VAL MET ALA GLY SER GLY ASN LEU LYS          
SEQRES 119 A 1944  VAL LEU GLN LEU CYS ARG PHE LEU HIS MET LYS THR GLY          
SEQRES 120 A 1944  GLY GLU MET ASN TYR GLY PHE HIS LEU ALA HIS HIS MET          
SEQRES 121 A 1944  ALA LEU GLY LEU LEU PHE LEU GLY GLY GLY ARG TYR SER          
SEQRES 122 A 1944  LEU SER THR SER ASN SER SER ILE ALA ALA LEU LEU CYS          
SEQRES 123 A 1944  ALA LEU TYR PRO HIS PHE PRO ALA HIS SER THR ASP ASN          
SEQRES 124 A 1944  ARG TYR HIS LEU GLN ALA LEU ARG HIS LEU TYR VAL LEU          
SEQRES 125 A 1944  ALA ALA GLU PRO ARG LEU LEU VAL PRO VAL ASP VAL ASP          
SEQRES 126 A 1944  THR ASN THR PRO CYS TYR ALA LEU LEU GLU VAL THR TYR          
SEQRES 127 A 1944  LYS GLY THR GLN TRP TYR GLU GLN THR LYS GLU GLU LEU          
SEQRES 128 A 1944  MET ALA PRO THR LEU LEU PRO GLU LEU HIS LEU LEU LYS          
SEQRES 129 A 1944  GLN ILE LYS VAL LYS GLY PRO ARG TYR TRP GLU LEU LEU          
SEQRES 130 A 1944  ILE ASP LEU SER LYS GLY THR GLN HIS LEU LYS SER ILE          
SEQRES 131 A 1944  LEU SER LYS ASP GLY VAL LEU TYR VAL LYS LEU ARG ALA          
SEQRES 132 A 1944  GLY GLN LEU SER TYR LYS GLU ASP PRO MET GLY TRP GLN          
SEQRES 133 A 1944  SER LEU LEU ALA GLN THR VAL ALA ASN ARG ASN SER GLU          
SEQRES 134 A 1944  ALA ARG ALA PHE LYS PRO GLU THR ILE SER ALA PHE THR          
SEQRES 135 A 1944  SER ASP PRO ALA LEU LEU SER PHE ALA GLU TYR PHE CYS          
SEQRES 136 A 1944  LYS PRO THR VAL ASN MET GLY GLN LYS GLN GLU ILE LEU          
SEQRES 137 A 1944  ASP LEU PHE SER SER VAL LEU TYR GLU CYS VAL THR GLN          
SEQRES 138 A 1944  GLU THR PRO GLU MET LEU PRO ALA TYR ILE ALA MET ASP          
SEQRES 139 A 1944  GLN ALA ILE ARG ARG LEU GLY ARG ARG GLU MET SER GLU          
SEQRES 140 A 1944  THR SER GLU LEU TRP GLN ILE LYS LEU VAL LEU GLU PHE          
SEQRES 141 A 1944  PHE SER SER ARG SER HIS GLN GLU ARG LEU GLN ASN HIS          
SEQRES 142 A 1944  PRO LYS ARG GLY LEU PHE MET ASN SER GLU PHE LEU PRO          
SEQRES 143 A 1944  VAL VAL LYS CYS THR ILE ASP ASN THR LEU ASP GLN TRP          
SEQRES 144 A 1944  LEU GLN VAL GLY GLY ASP MET CYS VAL HIS ALA TYR LEU          
SEQRES 145 A 1944  SER GLY GLN PRO LEU GLU GLU SER GLN LEU SER MET LEU          
SEQRES 146 A 1944  ALA CYS PHE LEU VAL TYR HIS SER VAL PRO ALA PRO GLN          
SEQRES 147 A 1944  HIS LEU PRO PRO ILE GLY LEU GLU GLY SER THR SER PHE          
SEQRES 148 A 1944  ALA GLU LEU LEU PHE LYS PHE LYS GLN LEU LYS MET PRO          
SEQRES 149 A 1944  VAL ARG ALA LEU LEU ARG LEU ALA PRO LEU LEU LEU GLY          
SEQRES 150 A 1944  ASN PRO GLN PRO MET VAL MET                                  
SEQRES   1 B   84  MET LYS VAL LYS ILE LYS CYS TRP ASN GLY VAL ALA THR          
SEQRES   2 B   84  TRP LEU TRP VAL ALA ASN ASP GLU ASN CYS GLY ILE CYS          
SEQRES   3 B   84  ARG MET ALA PHE ASN GLY CYS CYS PRO ASP CYS LYS VAL          
SEQRES   4 B   84  PRO GLY ASP ASP CYS PRO LEU VAL TRP GLY GLN CYS SER          
SEQRES   5 B   84  HIS CYS PHE HIS MET HIS CYS ILE LEU LYS TRP LEU HIS          
SEQRES   6 B   84  ALA GLN GLN VAL GLN GLN HIS CYS PRO MET CYS ARG GLN          
SEQRES   7 B   84  GLU TRP LYS PHE LYS GLU                                      
SEQRES   1 C  597  MET ALA ALA SER THR SER MET VAL PRO VAL ALA VAL THR          
SEQRES   2 C  597  ALA ALA VAL ALA PRO VAL LEU SER ILE ASN SER ASP PHE          
SEQRES   3 C  597  SER ASP LEU ARG GLU ILE LYS LYS GLN LEU LEU LEU ILE          
SEQRES   4 C  597  ALA GLY LEU THR ARG GLU ARG GLY LEU LEU HIS SER SER          
SEQRES   5 C  597  LYS TRP SER ALA GLU LEU ALA PHE SER LEU PRO ALA LEU          
SEQRES   6 C  597  PRO LEU ALA GLU LEU GLN PRO PRO PRO PRO ILE THR GLU          
SEQRES   7 C  597  GLU ASP ALA GLN ASP MET ASP ALA TYR THR LEU ALA LYS          
SEQRES   8 C  597  ALA TYR PHE ASP VAL LYS GLU TYR ASP ARG ALA ALA HIS          
SEQRES   9 C  597  PHE LEU HIS GLY CYS ASN SER LYS LYS ALA TYR PHE LEU          
SEQRES  10 C  597  TYR MET TYR SER ARG TYR LEU SER GLY GLU LYS LYS LYS          
SEQRES  11 C  597  ASP ASP GLU THR VAL ASP SER LEU GLY PRO LEU GLU LYS          
SEQRES  12 C  597  GLY GLN VAL LYS ASN GLU ALA LEU ARG GLU LEU ARG VAL          
SEQRES  13 C  597  GLU LEU SER LYS LYS HIS GLN ALA ARG GLU LEU ASP GLY          
SEQRES  14 C  597  PHE GLY LEU TYR LEU TYR GLY VAL VAL LEU ARG LYS LEU          
SEQRES  15 C  597  ASP LEU VAL LYS GLU ALA ILE ASP VAL PHE VAL GLU ALA          
SEQRES  16 C  597  THR HIS VAL LEU PRO LEU HIS TRP GLY ALA TRP LEU GLU          
SEQRES  17 C  597  LEU CYS ASN LEU ILE THR ASP LYS GLU MET LEU LYS PHE          
SEQRES  18 C  597  LEU SER LEU PRO ASP THR TRP MET LYS GLU PHE PHE LEU          
SEQRES  19 C  597  ALA HIS ILE TYR THR GLU LEU GLN LEU ILE GLU GLU ALA          
SEQRES  20 C  597  LEU GLN LYS TYR GLN ASN LEU ILE ASP VAL GLY PHE SER          
SEQRES  21 C  597  LYS SER SER TYR ILE VAL SER GLN ILE ALA VAL ALA TYR          
SEQRES  22 C  597  HIS ASN ILE ARG ASP ILE ASP LYS ALA LEU SER ILE PHE          
SEQRES  23 C  597  ASN GLU LEU ARG LYS GLN ASP PRO TYR ARG ILE GLU ASN          
SEQRES  24 C  597  MET ASP THR PHE SER ASN LEU LEU TYR VAL ARG SER MET          
SEQRES  25 C  597  LYS SER GLU LEU SER TYR LEU ALA HIS ASN LEU CYS GLU          
SEQRES  26 C  597  ILE ASP LYS TYR ARG VAL GLU THR CYS CYS VAL ILE GLY          
SEQRES  27 C  597  ASN TYR TYR SER LEU ARG SER GLN HIS GLU LYS ALA ALA          
SEQRES  28 C  597  LEU TYR PHE GLN ARG ALA LEU LYS LEU ASN PRO ARG TYR          
SEQRES  29 C  597  LEU GLY ALA TRP THR LEU MET GLY HIS GLU TYR MET GLU          
SEQRES  30 C  597  MET LYS ASN THR SER ALA ALA ILE GLN ALA TYR ARG HIS          
SEQRES  31 C  597  ALA ILE GLU VAL ASN LYS ARG ASP TYR ARG ALA TRP TYR          
SEQRES  32 C  597  GLY LEU GLY GLN THR TYR GLU ILE LEU LYS MET PRO PHE          
SEQRES  33 C  597  TYR CYS LEU TYR TYR TYR ARG ARG ALA HIS GLN LEU ARG          
SEQRES  34 C  597  PRO ASN ASP SER ARG MET LEU VAL ALA LEU GLY GLU CYS          
SEQRES  35 C  597  TYR GLU LYS LEU ASN GLN LEU VAL GLU ALA LYS LYS CYS          
SEQRES  36 C  597  TYR TRP ARG ALA TYR ALA VAL GLY ASP VAL GLU LYS MET          
SEQRES  37 C  597  ALA LEU VAL LYS LEU ALA LYS LEU HIS GLU GLN LEU THR          
SEQRES  38 C  597  GLU SER GLU GLN ALA ALA GLN CYS TYR ILE LYS TYR ILE          
SEQRES  39 C  597  GLN ASP ILE TYR SER CYS GLY GLU ILE VAL GLU HIS LEU          
SEQRES  40 C  597  GLU GLU SER THR ALA PHE ARG TYR LEU ALA GLN TYR TYR          
SEQRES  41 C  597  PHE LYS CYS LYS LEU TRP ASP GLU ALA SER THR CYS ALA          
SEQRES  42 C  597  GLN LYS CYS CYS ALA PHE ASN ASP THR ARG GLU GLU GLY          
SEQRES  43 C  597  LYS ALA LEU LEU ARG GLN ILE LEU GLN LEU ARG ASN GLN          
SEQRES  44 C  597  GLY GLU THR PRO THR THR GLU VAL PRO ALA PRO PHE PHE          
SEQRES  45 C  597  LEU PRO ALA SER LEU SER ALA ASN ASN THR PRO THR ARG          
SEQRES  46 C  597  ARG VAL SER PRO LEU ASN LEU SER SER VAL THR PRO              
SEQRES   1 D  121  MET SER THR LEU PHE PRO SER LEU PHE PRO ARG VAL THR          
SEQRES   2 D  121  GLU THR LEU TRP PHE ASN LEU ASP ARG PRO CYS VAL GLU          
SEQRES   3 D  121  GLU THR GLU LEU GLN GLN GLN GLU GLN GLN HIS GLN ALA          
SEQRES   4 D  121  TRP LEU GLN SER ILE ALA GLU LYS ASP ASN ASN LEU VAL          
SEQRES   5 D  121  PRO ILE GLY LYS PRO ALA SER GLU HIS TYR ASP ASP GLU          
SEQRES   6 D  121  GLU GLU GLU ASP ASP GLU ASP ASP GLU ASP SER GLU GLU          
SEQRES   7 D  121  ASP SER GLU ASP ASP GLU ASP MET GLN ASP MET ASP GLU          
SEQRES   8 D  121  MET ASN ASP TYR ASN GLU SER PRO ASP ASP GLY GLU VAL          
SEQRES   9 D  121  ASN GLU VAL ASP MET GLU GLY ASN GLU GLN ASP GLN ASP          
SEQRES  10 D  121  GLN TRP MET ILE                                              
SEQRES   1 E  110  MET ALA ALA SER SER SER SER SER SER ALA GLY GLY VAL          
SEQRES   2 E  110  SER GLY SER SER VAL THR GLY SER GLY PHE SER VAL SER          
SEQRES   3 E  110  ASP LEU ALA PRO PRO ARG LYS ALA LEU PHE THR TYR PRO          
SEQRES   4 E  110  LYS GLY ALA GLY GLU MET LEU GLU ASP GLY SER GLU ARG          
SEQRES   5 E  110  PHE LEU CYS GLU SER VAL PHE SER TYR GLN VAL ALA SER          
SEQRES   6 E  110  THR LEU LYS GLN VAL LYS HIS ASP GLN GLN VAL ALA ARG          
SEQRES   7 E  110  MET GLU LYS LEU ALA GLY LEU VAL GLU GLU LEU GLU ALA          
SEQRES   8 E  110  ASP GLU TRP ARG PHE LYS PRO ILE GLU GLN LEU LEU GLY          
SEQRES   9 E  110  PHE THR PRO SER SER GLY                                      
SEQRES   1 F  824  MET THR VAL LEU GLN GLU PRO VAL GLN ALA ALA ILE TRP          
SEQRES   2 F  824  GLN ALA LEU ASN HIS TYR ALA TYR ARG ASP ALA VAL PHE          
SEQRES   3 F  824  LEU ALA GLU ARG LEU TYR ALA GLU VAL HIS SER GLU GLU          
SEQRES   4 F  824  ALA LEU PHE LEU LEU ALA THR CYS TYR TYR ARG SER GLY          
SEQRES   5 F  824  LYS ALA TYR LYS ALA TYR ARG LEU LEU LYS GLY HIS SER          
SEQRES   6 F  824  CYS THR THR PRO GLN CYS LYS TYR LEU LEU ALA LYS CYS          
SEQRES   7 F  824  CYS VAL ASP LEU SER LYS LEU ALA GLU GLY GLU GLN ILE          
SEQRES   8 F  824  LEU SER GLY GLY VAL PHE ASN LYS GLN LYS SER HIS ASP          
SEQRES   9 F  824  ASP ILE VAL THR GLU PHE GLY ASP SER ALA CYS PHE THR          
SEQRES  10 F  824  LEU SER LEU LEU GLY HIS VAL TYR CYS LYS THR ASP ARG          
SEQRES  11 F  824  LEU ALA LYS GLY SER GLU CYS TYR GLN LYS SER LEU SER          
SEQRES  12 F  824  LEU ASN PRO PHE LEU TRP SER PRO PHE GLU SER LEU CYS          
SEQRES  13 F  824  GLU ILE GLY GLU LYS PRO ASP PRO ASP GLN THR PHE LYS          
SEQRES  14 F  824  PHE THR SER LEU GLN ASN PHE SER ASN CYS LEU PRO ASN          
SEQRES  15 F  824  SER CYS THR THR GLN VAL PRO ASN HIS SER LEU SER HIS          
SEQRES  16 F  824  ARG GLN PRO GLU THR VAL LEU THR GLU THR PRO GLN ASP          
SEQRES  17 F  824  THR ILE GLU LEU ASN ARG LEU ASN LEU GLU SER SER ASN          
SEQRES  18 F  824  SER LYS TYR SER LEU ASN THR ASP SER SER VAL SER TYR          
SEQRES  19 F  824  ILE ASP SER ALA VAL ILE SER PRO ASP THR VAL PRO LEU          
SEQRES  20 F  824  GLY THR GLY THR SER ILE LEU SER LYS GLN VAL GLN ASN          
SEQRES  21 F  824  LYS PRO LYS THR GLY ARG SER LEU LEU GLY GLY PRO ALA          
SEQRES  22 F  824  ALA LEU SER PRO LEU THR PRO SER PHE GLY ILE LEU PRO          
SEQRES  23 F  824  LEU GLU THR PRO SER PRO GLY ASP GLY SER TYR LEU GLN          
SEQRES  24 F  824  ASN TYR THR ASN THR PRO PRO VAL ILE ASP VAL PRO SER          
SEQRES  25 F  824  THR GLY ALA PRO SER LYS LYS SER VAL ALA ARG ILE GLY          
SEQRES  26 F  824  GLN THR GLY THR LYS SER VAL PHE SER GLN SER GLY ASN          
SEQRES  27 F  824  SER ARG GLU VAL THR PRO ILE LEU ALA GLN THR GLN SER          
SEQRES  28 F  824  SER GLY PRO GLN THR SER THR THR PRO GLN VAL LEU SER          
SEQRES  29 F  824  PRO THR ILE THR SER PRO PRO ASN ALA LEU PRO ARG ARG          
SEQRES  30 F  824  SER SER ARG LEU PHE THR SER ASP SER SER THR THR LYS          
SEQRES  31 F  824  GLU ASN SER LYS LYS LEU LYS MET LYS PHE PRO PRO LYS          
SEQRES  32 F  824  ILE PRO ASN ARG LYS THR LYS SER LYS THR ASN LYS GLY          
SEQRES  33 F  824  GLY ILE THR GLN PRO ASN ILE ASN ASP SER LEU GLU ILE          
SEQRES  34 F  824  THR LYS LEU ASP SER SER ILE ILE SER GLU GLY LYS ILE          
SEQRES  35 F  824  SER THR ILE THR PRO GLN ILE GLN ALA PHE ASN LEU GLN          
SEQRES  36 F  824  LYS ALA ALA ALA GLU GLY LEU MET SER LEU LEU ARG GLU          
SEQRES  37 F  824  MET GLY LYS GLY TYR LEU ALA LEU CYS SER TYR ASN CYS          
SEQRES  38 F  824  LYS GLU ALA ILE ASN ILE LEU SER HIS LEU PRO SER HIS          
SEQRES  39 F  824  HIS TYR ASN THR GLY TRP VAL LEU CYS GLN ILE GLY ARG          
SEQRES  40 F  824  ALA TYR PHE GLU LEU SER GLU TYR MET GLN ALA GLU ARG          
SEQRES  41 F  824  ILE PHE SER GLU VAL ARG ARG ILE GLU ASN TYR ARG VAL          
SEQRES  42 F  824  GLU GLY MET GLU ILE TYR SER THR THR LEU TRP HIS LEU          
SEQRES  43 F  824  GLN LYS ASP VAL ALA LEU SER VAL LEU SER LYS ASP LEU          
SEQRES  44 F  824  THR ASP MET ASP LYS ASN SER PRO GLU ALA TRP CYS ALA          
SEQRES  45 F  824  ALA GLY ASN CYS PHE SER LEU GLN ARG GLU HIS ASP ILE          
SEQRES  46 F  824  ALA ILE LYS PHE PHE GLN ARG ALA ILE GLN VAL ASP PRO          
SEQRES  47 F  824  ASN TYR ALA TYR ALA TYR THR LEU LEU GLY HIS GLU PHE          
SEQRES  48 F  824  VAL LEU THR GLU GLU LEU ASP LYS ALA LEU ALA CYS PHE          
SEQRES  49 F  824  ARG ASN ALA ILE ARG VAL ASN PRO ARG HIS TYR ASN ALA          
SEQRES  50 F  824  TRP TYR GLY LEU GLY MET ILE TYR TYR LYS GLN GLU LYS          
SEQRES  51 F  824  PHE SER LEU ALA GLU MET HIS PHE GLN LYS ALA LEU ASP          
SEQRES  52 F  824  ILE ASN PRO GLN SER SER VAL LEU LEU CYS HIS ILE GLY          
SEQRES  53 F  824  VAL VAL GLN HIS ALA LEU LYS LYS SER GLU LYS ALA LEU          
SEQRES  54 F  824  ASP THR LEU ASN LYS ALA ILE VAL ILE ASP PRO LYS ASN          
SEQRES  55 F  824  PRO LEU CYS LYS PHE HIS ARG ALA SER VAL LEU PHE ALA          
SEQRES  56 F  824  ASN GLU LYS TYR LYS SER ALA LEU GLN GLU LEU GLU GLU          
SEQRES  57 F  824  LEU LYS GLN ILE VAL PRO LYS GLU SER LEU VAL TYR PHE          
SEQRES  58 F  824  LEU ILE GLY LYS VAL TYR LYS LYS LEU GLY GLN THR HIS          
SEQRES  59 F  824  LEU ALA LEU MET ASN PHE SER TRP ALA MET ASP LEU ASP          
SEQRES  60 F  824  PRO LYS GLY ALA ASN ASN GLN ILE LYS GLU ALA ILE ASP          
SEQRES  61 F  824  LYS ARG TYR LEU PRO ASP ASP GLU GLU PRO ILE THR GLN          
SEQRES  62 F  824  GLU GLU GLN ILE MET GLY THR ASP GLU SER GLN GLU SER          
SEQRES  63 F  824  SER MET THR ASP ALA ASP ASP THR GLN LEU HIS ALA ALA          
SEQRES  64 F  824  GLU SER ASP GLU PHE                                          
SEQRES   1 G   85  MET LEU ARG ARG LYS PRO THR ARG LEU GLU LEU LYS LEU          
SEQRES   2 G   85  ASP ASP ILE GLU GLU PHE GLU ASN ILE ARG LYS ASP LEU          
SEQRES   3 G   85  GLU THR ARG LYS LYS GLN LYS GLU ASP VAL GLU VAL VAL          
SEQRES   4 G   85  GLY GLY SER ASP GLY GLU GLY ALA ILE GLY LEU SER SER          
SEQRES   5 G   85  ASP PRO LYS SER ARG GLU GLN MET ILE ASN ASP ARG ILE          
SEQRES   6 G   85  GLY TYR LYS PRO GLN PRO LYS PRO ASN ASN ARG SER SER          
SEQRES   7 G   85  GLN PHE GLY SER LEU GLU PHE                                  
SEQRES   1 H  824  MET THR VAL LEU GLN GLU PRO VAL GLN ALA ALA ILE TRP          
SEQRES   2 H  824  GLN ALA LEU ASN HIS TYR ALA TYR ARG ASP ALA VAL PHE          
SEQRES   3 H  824  LEU ALA GLU ARG LEU TYR ALA GLU VAL HIS SER GLU GLU          
SEQRES   4 H  824  ALA LEU PHE LEU LEU ALA THR CYS TYR TYR ARG SER GLY          
SEQRES   5 H  824  LYS ALA TYR LYS ALA TYR ARG LEU LEU LYS GLY HIS SER          
SEQRES   6 H  824  CYS THR THR PRO GLN CYS LYS TYR LEU LEU ALA LYS CYS          
SEQRES   7 H  824  CYS VAL ASP LEU SER LYS LEU ALA GLU GLY GLU GLN ILE          
SEQRES   8 H  824  LEU SER GLY GLY VAL PHE ASN LYS GLN LYS SER HIS ASP          
SEQRES   9 H  824  ASP ILE VAL THR GLU PHE GLY ASP SER ALA CYS PHE THR          
SEQRES  10 H  824  LEU SER LEU LEU GLY HIS VAL TYR CYS LYS THR ASP ARG          
SEQRES  11 H  824  LEU ALA LYS GLY SER GLU CYS TYR GLN LYS SER LEU SER          
SEQRES  12 H  824  LEU ASN PRO PHE LEU TRP SER PRO PHE GLU SER LEU CYS          
SEQRES  13 H  824  GLU ILE GLY GLU LYS PRO ASP PRO ASP GLN THR PHE LYS          
SEQRES  14 H  824  PHE THR SER LEU GLN ASN PHE SER ASN CYS LEU PRO ASN          
SEQRES  15 H  824  SER CYS THR THR GLN VAL PRO ASN HIS SER LEU SER HIS          
SEQRES  16 H  824  ARG GLN PRO GLU THR VAL LEU THR GLU THR PRO GLN ASP          
SEQRES  17 H  824  THR ILE GLU LEU ASN ARG LEU ASN LEU GLU SER SER ASN          
SEQRES  18 H  824  SER LYS TYR SER LEU ASN THR ASP SER SER VAL SER TYR          
SEQRES  19 H  824  ILE ASP SER ALA VAL ILE SER PRO ASP THR VAL PRO LEU          
SEQRES  20 H  824  GLY THR GLY THR SER ILE LEU SER LYS GLN VAL GLN ASN          
SEQRES  21 H  824  LYS PRO LYS THR GLY ARG SER LEU LEU GLY GLY PRO ALA          
SEQRES  22 H  824  ALA LEU SER PRO LEU THR PRO SER PHE GLY ILE LEU PRO          
SEQRES  23 H  824  LEU GLU THR PRO SER PRO GLY ASP GLY SER TYR LEU GLN          
SEQRES  24 H  824  ASN TYR THR ASN THR PRO PRO VAL ILE ASP VAL PRO SER          
SEQRES  25 H  824  THR GLY ALA PRO SER LYS LYS SER VAL ALA ARG ILE GLY          
SEQRES  26 H  824  GLN THR GLY THR LYS SER VAL PHE SER GLN SER GLY ASN          
SEQRES  27 H  824  SER ARG GLU VAL THR PRO ILE LEU ALA GLN THR GLN SER          
SEQRES  28 H  824  SER GLY PRO GLN THR SER THR THR PRO GLN VAL LEU SER          
SEQRES  29 H  824  PRO THR ILE THR SER PRO PRO ASN ALA LEU PRO ARG ARG          
SEQRES  30 H  824  SER SER ARG LEU PHE THR SER ASP SER SER THR THR LYS          
SEQRES  31 H  824  GLU ASN SER LYS LYS LEU LYS MET LYS PHE PRO PRO LYS          
SEQRES  32 H  824  ILE PRO ASN ARG LYS THR LYS SER LYS THR ASN LYS GLY          
SEQRES  33 H  824  GLY ILE THR GLN PRO ASN ILE ASN ASP SER LEU GLU ILE          
SEQRES  34 H  824  THR LYS LEU ASP SER SER ILE ILE SER GLU GLY LYS ILE          
SEQRES  35 H  824  SER THR ILE THR PRO GLN ILE GLN ALA PHE ASN LEU GLN          
SEQRES  36 H  824  LYS ALA ALA ALA GLU GLY LEU MET SER LEU LEU ARG GLU          
SEQRES  37 H  824  MET GLY LYS GLY TYR LEU ALA LEU CYS SER TYR ASN CYS          
SEQRES  38 H  824  LYS GLU ALA ILE ASN ILE LEU SER HIS LEU PRO SER HIS          
SEQRES  39 H  824  HIS TYR ASN THR GLY TRP VAL LEU CYS GLN ILE GLY ARG          
SEQRES  40 H  824  ALA TYR PHE GLU LEU SER GLU TYR MET GLN ALA GLU ARG          
SEQRES  41 H  824  ILE PHE SER GLU VAL ARG ARG ILE GLU ASN TYR ARG VAL          
SEQRES  42 H  824  GLU GLY MET GLU ILE TYR SER THR THR LEU TRP HIS LEU          
SEQRES  43 H  824  GLN LYS ASP VAL ALA LEU SER VAL LEU SER LYS ASP LEU          
SEQRES  44 H  824  THR ASP MET ASP LYS ASN SER PRO GLU ALA TRP CYS ALA          
SEQRES  45 H  824  ALA GLY ASN CYS PHE SER LEU GLN ARG GLU HIS ASP ILE          
SEQRES  46 H  824  ALA ILE LYS PHE PHE GLN ARG ALA ILE GLN VAL ASP PRO          
SEQRES  47 H  824  ASN TYR ALA TYR ALA TYR THR LEU LEU GLY HIS GLU PHE          
SEQRES  48 H  824  VAL LEU THR GLU GLU LEU ASP LYS ALA LEU ALA CYS PHE          
SEQRES  49 H  824  ARG ASN ALA ILE ARG VAL ASN PRO ARG HIS TYR ASN ALA          
SEQRES  50 H  824  TRP TYR GLY LEU GLY MET ILE TYR TYR LYS GLN GLU LYS          
SEQRES  51 H  824  PHE SER LEU ALA GLU MET HIS PHE GLN LYS ALA LEU ASP          
SEQRES  52 H  824  ILE ASN PRO GLN SER SER VAL LEU LEU CYS HIS ILE GLY          
SEQRES  53 H  824  VAL VAL GLN HIS ALA LEU LYS LYS SER GLU LYS ALA LEU          
SEQRES  54 H  824  ASP THR LEU ASN LYS ALA ILE VAL ILE ASP PRO LYS ASN          
SEQRES  55 H  824  PRO LEU CYS LYS PHE HIS ARG ALA SER VAL LEU PHE ALA          
SEQRES  56 H  824  ASN GLU LYS TYR LYS SER ALA LEU GLN GLU LEU GLU GLU          
SEQRES  57 H  824  LEU LYS GLN ILE VAL PRO LYS GLU SER LEU VAL TYR PHE          
SEQRES  58 H  824  LEU ILE GLY LYS VAL TYR LYS LYS LEU GLY GLN THR HIS          
SEQRES  59 H  824  LEU ALA LEU MET ASN PHE SER TRP ALA MET ASP LEU ASP          
SEQRES  60 H  824  PRO LYS GLY ALA ASN ASN GLN ILE LYS GLU ALA ILE ASP          
SEQRES  61 H  824  LYS ARG TYR LEU PRO ASP ASP GLU GLU PRO ILE THR GLN          
SEQRES  62 H  824  GLU GLU GLN ILE MET GLY THR ASP GLU SER GLN GLU SER          
SEQRES  63 H  824  SER MET THR ASP ALA ASP ASP THR GLN LEU HIS ALA ALA          
SEQRES  64 H  824  GLU SER ASP GLU PHE                                          
SEQRES   1 I  808  MET LEU ARG PHE PRO THR CYS PHE PRO SER PHE ARG VAL          
SEQRES   2 I  808  VAL GLY GLU LYS GLN LEU PRO GLN GLU ILE ILE PHE LEU          
SEQRES   3 I  808  VAL TRP SER PRO LYS ARG ASP LEU ILE ALA LEU ALA ASN          
SEQRES   4 I  808  THR ALA GLY GLU VAL LEU LEU HIS ARG LEU ALA SER PHE          
SEQRES   5 I  808  HIS ARG VAL TRP SER PHE PRO PRO ASN GLU ASN THR GLY          
SEQRES   6 I  808  LYS GLU VAL THR CYS LEU ALA TRP ARG PRO ASP GLY LYS          
SEQRES   7 I  808  LEU LEU ALA PHE ALA LEU ALA ASP THR LYS LYS ILE VAL          
SEQRES   8 I  808  LEU CYS ASP VAL GLU LYS PRO GLU SER LEU HIS SER PHE          
SEQRES   9 I  808  SER VAL GLU ALA PRO VAL SER CYS MET HIS TRP MET GLU          
SEQRES  10 I  808  VAL THR VAL GLU SER SER VAL LEU THR SER PHE TYR ASN          
SEQRES  11 I  808  ALA GLU ASP GLU SER ASN LEU LEU LEU PRO LYS LEU PRO          
SEQRES  12 I  808  THR LEU PRO LYS ASN TYR SER ASN THR SER LYS ILE PHE          
SEQRES  13 I  808  SER GLU GLU ASN SER ASP GLU ILE ILE LYS LEU LEU GLY          
SEQRES  14 I  808  ASP VAL ARG LEU ASN ILE LEU VAL LEU GLY GLY SER SER          
SEQRES  15 I  808  GLY PHE ILE GLU LEU TYR ALA TYR GLY MET PHE LYS ILE          
SEQRES  16 I  808  ALA ARG VAL THR GLY ILE ALA GLY THR CYS LEU ALA LEU          
SEQRES  17 I  808  CYS LEU SER SER ASP LEU LYS SER LEU SER VAL VAL THR          
SEQRES  18 I  808  GLU VAL SER THR ASN GLY ALA SER GLU VAL SER TYR PHE          
SEQRES  19 I  808  GLN LEU GLU THR ASN LEU LEU TYR SER PHE LEU PRO GLU          
SEQRES  20 I  808  VAL THR ARG MET ALA ARG LYS PHE THR HIS ILE SER ALA          
SEQRES  21 I  808  LEU LEU GLN TYR ILE ASN LEU SER LEU THR CYS MET CYS          
SEQRES  22 I  808  GLU ALA TRP GLU GLU ILE LEU MET GLN MET ASP SER ARG          
SEQRES  23 I  808  LEU THR LYS PHE VAL GLN GLU LYS ASN THR THR THR SER          
SEQRES  24 I  808  VAL GLN ASP GLU PHE MET HIS LEU LEU LEU TRP GLY LYS          
SEQRES  25 I  808  ALA SER ALA GLU LEU GLN THR LEU LEU MET ASN GLN LEU          
SEQRES  26 I  808  THR VAL LYS GLY LEU LYS LYS LEU GLY GLN SER ILE GLU          
SEQRES  27 I  808  SER SER TYR SER SER ILE GLN LYS LEU VAL ILE SER HIS          
SEQRES  28 I  808  LEU GLN SER GLY SER GLU SER LEU LEU TYR HIS LEU SER          
SEQRES  29 I  808  GLU LEU LYS GLY MET ALA SER TRP LYS GLN LYS TYR GLU          
SEQRES  30 I  808  PRO LEU GLY LEU ASP ALA ALA GLY ILE GLU GLU ALA ILE          
SEQRES  31 I  808  THR ALA VAL GLY SER PHE ILE LEU LYS ALA ASN GLU LEU          
SEQRES  32 I  808  LEU GLN VAL ILE ASP SER SER MET LYS ASN PHE LYS ALA          
SEQRES  33 I  808  PHE PHE ARG TRP LEU TYR VAL ALA MET LEU ARG MET THR          
SEQRES  34 I  808  GLU ASP HIS VAL LEU PRO GLU LEU ASN LYS MET THR GLN          
SEQRES  35 I  808  LYS ASP ILE THR PHE VAL ALA GLU PHE LEU THR GLU HIS          
SEQRES  36 I  808  PHE ASN GLU ALA PRO ASP LEU TYR ASN ARG LYS GLY LYS          
SEQRES  37 I  808  TYR PHE ASN VAL GLU ARG VAL GLY GLN TYR LEU LYS ASP          
SEQRES  38 I  808  GLU ASP ASP ASP LEU VAL SER PRO PRO ASN THR GLU GLY          
SEQRES  39 I  808  ASN GLN TRP TYR ASP PHE LEU GLN ASN SER SER HIS LEU          
SEQRES  40 I  808  LYS GLU SER PRO LEU LEU PHE PRO TYR TYR PRO ARG LYS          
SEQRES  41 I  808  SER LEU HIS PHE VAL LYS ARG ARG MET GLU ASN ILE ILE          
SEQRES  42 I  808  ASP GLN CYS LEU GLN LYS PRO ALA ASP VAL ILE GLY LYS          
SEQRES  43 I  808  SER MET ASN GLN ALA ILE CYS ILE PRO LEU TYR ARG ASP          
SEQRES  44 I  808  THR ARG SER GLU ASP SER THR ARG ARG LEU PHE LYS PHE          
SEQRES  45 I  808  PRO PHE LEU TRP ASN ASN LYS THR SER ASN LEU HIS TYR          
SEQRES  46 I  808  LEU LEU PHE THR ILE LEU GLU ASP SER LEU TYR LYS MET          
SEQRES  47 I  808  CYS ILE LEU ARG ARG HIS THR ASP ILE SER GLN SER VAL          
SEQRES  48 I  808  SER ASN GLY LEU ILE ALA ILE LYS PHE GLY SER PHE THR          
SEQRES  49 I  808  TYR ALA THR THR GLU LYS VAL ARG ARG SER ILE TYR SER          
SEQRES  50 I  808  CYS LEU ASP ALA GLN PHE TYR ASP ASP GLU THR VAL THR          
SEQRES  51 I  808  VAL VAL LEU LYS ASP THR VAL GLY ARG GLU GLY ARG ASP          
SEQRES  52 I  808  ARG LEU LEU VAL GLN LEU PRO LEU SER LEU VAL TYR ASN          
SEQRES  53 I  808  SER GLU ASP SER ALA GLU TYR GLN PHE THR GLY THR TYR          
SEQRES  54 I  808  SER THR ARG LEU ASP GLU GLN CYS SER ALA ILE PRO THR          
SEQRES  55 I  808  ARG THR MET HIS PHE GLU LYS HIS TRP ARG LEU LEU GLU          
SEQRES  56 I  808  SER MET LYS ALA GLN TYR VAL ALA GLY ASN GLY PHE ARG          
SEQRES  57 I  808  LYS VAL SER CYS VAL LEU SER SER ASN LEU ARG HIS VAL          
SEQRES  58 I  808  ARG VAL PHE GLU MET ASP ILE ASP ASP GLU TRP GLU LEU          
SEQRES  59 I  808  ASP GLU SER SER ASP GLU GLU GLU GLU ALA SER ASN LYS          
SEQRES  60 I  808  PRO VAL LYS ILE LYS GLU GLU VAL LEU SER GLU SER GLU          
SEQRES  61 I  808  ALA GLU ASN GLN GLN ALA GLY ALA ALA ALA LEU ALA PRO          
SEQRES  62 I  808  GLU ILE VAL ILE LYS VAL GLU LYS LEU ASP PRO GLU LEU          
SEQRES  63 I  808  ASP SER                                                      
SEQRES   1 J  620  MET ASN LEU GLU ARG LEU ARG LYS ARG VAL ARG GLN TYR          
SEQRES   2 J  620  LEU ASP GLN GLN GLN TYR GLN SER ALA LEU PHE TRP ALA          
SEQRES   3 J  620  ASP LYS VAL ALA SER LEU SER ARG GLU GLU PRO GLN ASP          
SEQRES   4 J  620  ILE TYR TRP LEU ALA GLN CYS LEU TYR LEU THR ALA GLN          
SEQRES   5 J  620  TYR HIS ARG ALA ALA HIS ALA LEU ARG SER ARG LYS LEU          
SEQRES   6 J  620  ASP LYS LEU TYR GLU ALA CYS ARG TYR LEU ALA ALA ARG          
SEQRES   7 J  620  CYS HIS TYR ALA ALA LYS GLU HIS GLN GLN ALA LEU ASP          
SEQRES   8 J  620  VAL LEU ASP MET GLU GLU PRO ILE ASN LYS ARG LEU PHE          
SEQRES   9 J  620  GLU LYS TYR LEU LYS ASP GLU SER GLY PHE LYS ASP PRO          
SEQRES  10 J  620  SER SER ASP TRP GLU MET SER GLN SER SER ILE LYS SER          
SEQRES  11 J  620  SER ILE CYS LEU LEU ARG GLY LYS ILE TYR ASP ALA LEU          
SEQRES  12 J  620  ASP ASN ARG THR LEU ALA THR TYR SER TYR LYS GLU ALA          
SEQRES  13 J  620  LEU LYS LEU ASP VAL TYR CYS PHE GLU ALA PHE ASP LEU          
SEQRES  14 J  620  LEU THR SER HIS HIS MET LEU THR ALA GLN GLU GLU LYS          
SEQRES  15 J  620  GLU LEU LEU GLU SER LEU PRO LEU SER LYS LEU CYS ASN          
SEQRES  16 J  620  GLU GLU GLN GLU LEU LEU ARG PHE LEU PHE GLU ASN LYS          
SEQRES  17 J  620  LEU LYS LYS TYR ASN LYS PRO SER GLU THR VAL ILE PRO          
SEQRES  18 J  620  GLU SER VAL ASP GLY LEU GLN GLU ASN LEU ASP VAL VAL          
SEQRES  19 J  620  VAL SER LEU ALA GLU ARG HIS TYR TYR ASN CYS ASP PHE          
SEQRES  20 J  620  LYS MET CYS TYR LYS LEU THR SER VAL VAL MET GLU LYS          
SEQRES  21 J  620  ASP PRO PHE HIS ALA SER CYS LEU PRO VAL HIS ILE GLY          
SEQRES  22 J  620  THR LEU VAL GLU LEU ASN LYS ALA ASN GLU LEU PHE TYR          
SEQRES  23 J  620  LEU SER HIS LYS LEU VAL ASP LEU TYR PRO SER ASN PRO          
SEQRES  24 J  620  VAL SER TRP PHE ALA VAL GLY CYS TYR TYR LEU MET VAL          
SEQRES  25 J  620  GLY HIS LYS ASN GLU HIS ALA ARG ARG TYR LEU SER LYS          
SEQRES  26 J  620  ALA THR THR LEU GLU LYS THR TYR GLY PRO ALA TRP ILE          
SEQRES  27 J  620  ALA TYR GLY HIS SER PHE ALA VAL GLU SER GLU HIS ASP          
SEQRES  28 J  620  GLN ALA MET ALA ALA TYR PHE THR ALA ALA GLN LEU MET          
SEQRES  29 J  620  LYS GLY CYS HIS LEU PRO MET LEU TYR ILE GLY LEU GLU          
SEQRES  30 J  620  TYR GLY LEU THR ASN ASN SER LYS LEU ALA GLU ARG PHE          
SEQRES  31 J  620  PHE SER GLN ALA LEU SER ILE ALA PRO GLU ASP PRO PHE          
SEQRES  32 J  620  VAL MET HIS GLU VAL GLY VAL VAL ALA PHE GLN ASN GLY          
SEQRES  33 J  620  GLU TRP LYS THR ALA GLU LYS TRP PHE LEU ASP ALA LEU          
SEQRES  34 J  620  GLU LYS ILE LYS ALA ILE GLY ASN GLU VAL THR VAL ASP          
SEQRES  35 J  620  LYS TRP GLU PRO LEU LEU ASN ASN LEU GLY HIS VAL CYS          
SEQRES  36 J  620  ARG LYS LEU LYS LYS TYR ALA GLU ALA LEU ASP TYR HIS          
SEQRES  37 J  620  ARG GLN ALA LEU VAL LEU ILE PRO GLN ASN ALA SER THR          
SEQRES  38 J  620  TYR SER ALA ILE GLY TYR ILE HIS SER LEU MET GLY ASN          
SEQRES  39 J  620  PHE GLU ASN ALA VAL ASP TYR PHE HIS THR ALA LEU GLY          
SEQRES  40 J  620  LEU ARG ARG ASP ASP THR PHE SER VAL THR MET LEU GLY          
SEQRES  41 J  620  HIS CYS ILE GLU MET TYR ILE GLY ASP SER GLU ALA TYR          
SEQRES  42 J  620  ILE GLY ALA ASP ILE LYS ASP LYS LEU LYS CYS TYR ASP          
SEQRES  43 J  620  PHE ASP VAL HIS THR MET LYS THR LEU LYS ASN ILE ILE          
SEQRES  44 J  620  SER PRO PRO TRP ASP PHE ARG GLU PHE GLU VAL GLU LYS          
SEQRES  45 J  620  GLN THR ALA GLU GLU THR GLY LEU THR PRO LEU GLU THR          
SEQRES  46 J  620  SER ARG LYS THR PRO ASP SER ARG PRO SER LEU GLU GLU          
SEQRES  47 J  620  THR PHE GLU ILE GLU MET ASN GLU SER ASP MET MET LEU          
SEQRES  48 J  620  GLU THR SER MET SER ASP HIS SER THR                          
SEQRES   1 K  620  MET ASN LEU GLU ARG LEU ARG LYS ARG VAL ARG GLN TYR          
SEQRES   2 K  620  LEU ASP GLN GLN GLN TYR GLN SER ALA LEU PHE TRP ALA          
SEQRES   3 K  620  ASP LYS VAL ALA SER LEU SER ARG GLU GLU PRO GLN ASP          
SEQRES   4 K  620  ILE TYR TRP LEU ALA GLN CYS LEU TYR LEU THR ALA GLN          
SEQRES   5 K  620  TYR HIS ARG ALA ALA HIS ALA LEU ARG SER ARG LYS LEU          
SEQRES   6 K  620  ASP LYS LEU TYR GLU ALA CYS ARG TYR LEU ALA ALA ARG          
SEQRES   7 K  620  CYS HIS TYR ALA ALA LYS GLU HIS GLN GLN ALA LEU ASP          
SEQRES   8 K  620  VAL LEU ASP MET GLU GLU PRO ILE ASN LYS ARG LEU PHE          
SEQRES   9 K  620  GLU LYS TYR LEU LYS ASP GLU SER GLY PHE LYS ASP PRO          
SEQRES  10 K  620  SER SER ASP TRP GLU MET SER GLN SER SER ILE LYS SER          
SEQRES  11 K  620  SER ILE CYS LEU LEU ARG GLY LYS ILE TYR ASP ALA LEU          
SEQRES  12 K  620  ASP ASN ARG THR LEU ALA THR TYR SER TYR LYS GLU ALA          
SEQRES  13 K  620  LEU LYS LEU ASP VAL TYR CYS PHE GLU ALA PHE ASP LEU          
SEQRES  14 K  620  LEU THR SER HIS HIS MET LEU THR ALA GLN GLU GLU LYS          
SEQRES  15 K  620  GLU LEU LEU GLU SER LEU PRO LEU SER LYS LEU CYS ASN          
SEQRES  16 K  620  GLU GLU GLN GLU LEU LEU ARG PHE LEU PHE GLU ASN LYS          
SEQRES  17 K  620  LEU LYS LYS TYR ASN LYS PRO SER GLU THR VAL ILE PRO          
SEQRES  18 K  620  GLU SER VAL ASP GLY LEU GLN GLU ASN LEU ASP VAL VAL          
SEQRES  19 K  620  VAL SER LEU ALA GLU ARG HIS TYR TYR ASN CYS ASP PHE          
SEQRES  20 K  620  LYS MET CYS TYR LYS LEU THR SER VAL VAL MET GLU LYS          
SEQRES  21 K  620  ASP PRO PHE HIS ALA SER CYS LEU PRO VAL HIS ILE GLY          
SEQRES  22 K  620  THR LEU VAL GLU LEU ASN LYS ALA ASN GLU LEU PHE TYR          
SEQRES  23 K  620  LEU SER HIS LYS LEU VAL ASP LEU TYR PRO SER ASN PRO          
SEQRES  24 K  620  VAL SER TRP PHE ALA VAL GLY CYS TYR TYR LEU MET VAL          
SEQRES  25 K  620  GLY HIS LYS ASN GLU HIS ALA ARG ARG TYR LEU SER LYS          
SEQRES  26 K  620  ALA THR THR LEU GLU LYS THR TYR GLY PRO ALA TRP ILE          
SEQRES  27 K  620  ALA TYR GLY HIS SER PHE ALA VAL GLU SER GLU HIS ASP          
SEQRES  28 K  620  GLN ALA MET ALA ALA TYR PHE THR ALA ALA GLN LEU MET          
SEQRES  29 K  620  LYS GLY CYS HIS LEU PRO MET LEU TYR ILE GLY LEU GLU          
SEQRES  30 K  620  TYR GLY LEU THR ASN ASN SER LYS LEU ALA GLU ARG PHE          
SEQRES  31 K  620  PHE SER GLN ALA LEU SER ILE ALA PRO GLU ASP PRO PHE          
SEQRES  32 K  620  VAL MET HIS GLU VAL GLY VAL VAL ALA PHE GLN ASN GLY          
SEQRES  33 K  620  GLU TRP LYS THR ALA GLU LYS TRP PHE LEU ASP ALA LEU          
SEQRES  34 K  620  GLU LYS ILE LYS ALA ILE GLY ASN GLU VAL THR VAL ASP          
SEQRES  35 K  620  LYS TRP GLU PRO LEU LEU ASN ASN LEU GLY HIS VAL CYS          
SEQRES  36 K  620  ARG LYS LEU LYS LYS TYR ALA GLU ALA LEU ASP TYR HIS          
SEQRES  37 K  620  ARG GLN ALA LEU VAL LEU ILE PRO GLN ASN ALA SER THR          
SEQRES  38 K  620  TYR SER ALA ILE GLY TYR ILE HIS SER LEU MET GLY ASN          
SEQRES  39 K  620  PHE GLU ASN ALA VAL ASP TYR PHE HIS THR ALA LEU GLY          
SEQRES  40 K  620  LEU ARG ARG ASP ASP THR PHE SER VAL THR MET LEU GLY          
SEQRES  41 K  620  HIS CYS ILE GLU MET TYR ILE GLY ASP SER GLU ALA TYR          
SEQRES  42 K  620  ILE GLY ALA ASP ILE LYS ASP LYS LEU LYS CYS TYR ASP          
SEQRES  43 K  620  PHE ASP VAL HIS THR MET LYS THR LEU LYS ASN ILE ILE          
SEQRES  44 K  620  SER PRO PRO TRP ASP PHE ARG GLU PHE GLU VAL GLU LYS          
SEQRES  45 K  620  GLN THR ALA GLU GLU THR GLY LEU THR PRO LEU GLU THR          
SEQRES  46 K  620  SER ARG LYS THR PRO ASP SER ARG PRO SER LEU GLU GLU          
SEQRES  47 K  620  THR PHE GLU ILE GLU MET ASN GLU SER ASP MET MET LEU          
SEQRES  48 K  620  GLU THR SER MET SER ASP HIS SER THR                          
SEQRES   1 L  185  MET THR THR PRO ASN LYS THR PRO PRO GLY ALA ASP PRO          
SEQRES   2 L  185  LYS GLN LEU GLU ARG THR GLY THR VAL ARG GLU ILE GLY          
SEQRES   3 L  185  SER GLN ALA VAL TRP SER LEU SER SER CYS LYS PRO GLY          
SEQRES   4 L  185  PHE GLY VAL ASP GLN LEU ARG ASP ASP ASN LEU GLU THR          
SEQRES   5 L  185  TYR TRP GLN SER ASP GLY SER GLN PRO HIS LEU VAL ASN          
SEQRES   6 L  185  ILE GLN PHE ARG ARG LYS THR THR VAL LYS THR LEU CYS          
SEQRES   7 L  185  ILE TYR ALA ASP TYR LYS SER ASP GLU SER TYR THR PRO          
SEQRES   8 L  185  SER LYS ILE SER VAL ARG VAL GLY ASN ASN PHE HIS ASN          
SEQRES   9 L  185  LEU GLN GLU ILE ARG GLN LEU GLU LEU VAL GLU PRO SER          
SEQRES  10 L  185  GLY TRP ILE HIS VAL PRO LEU THR ASP ASN HIS LYS LYS          
SEQRES  11 L  185  PRO THR ARG THR PHE MET ILE GLN ILE ALA VAL LEU ALA          
SEQRES  12 L  185  ASN HIS GLN ASN GLY ARG ASP THR HIS MET ARG GLN ILE          
SEQRES  13 L  185  LYS ILE TYR THR PRO VAL GLU GLU SER SER ILE GLY LYS          
SEQRES  14 L  185  PHE PRO ARG CYS THR THR ILE ASP PHE MET MET TYR ARG          
SEQRES  15 L  185  SER ILE ARG                                                  
SEQRES   1 M   74  MET ASP SER GLU VAL GLN ARG ASP GLY ARG ILE LEU ASP          
SEQRES   2 M   74  LEU ILE ASP ASP ALA TRP ARG GLU ASP LYS LEU PRO TYR          
SEQRES   3 M   74  GLU ASP VAL ALA ILE PRO LEU ASN GLU LEU PRO GLU PRO          
SEQRES   4 M   74  GLU GLN ASP ASN GLY GLY THR THR GLU SER VAL LYS GLU          
SEQRES   5 M   74  GLN GLU MET LYS TRP THR ASP LEU ALA LEU GLN TYR LEU          
SEQRES   6 M   74  HIS GLU ASN VAL PRO PRO ILE GLY ASN                          
SEQRES   1 N  822  MET ALA ALA ALA VAL VAL VAL ALA GLU GLY ASP SER ASP          
SEQRES   2 N  822  SER ARG PRO GLY GLN GLU LEU LEU VAL ALA TRP ASN THR          
SEQRES   3 N  822  VAL SER THR GLY LEU VAL PRO PRO ALA ALA LEU GLY LEU          
SEQRES   4 N  822  VAL SER SER ARG THR SER GLY ALA VAL PRO PRO LYS GLU          
SEQRES   5 N  822  GLU GLU LEU ARG ALA ALA VAL GLU VAL LEU ARG GLY HIS          
SEQRES   6 N  822  GLY LEU HIS SER VAL LEU GLU GLU TRP PHE VAL GLU VAL          
SEQRES   7 N  822  LEU GLN ASN ASP LEU GLN ALA ASN ILE SER PRO GLU PHE          
SEQRES   8 N  822  TRP ASN ALA ILE SER GLN CYS GLU ASN SER ALA ASP GLU          
SEQRES   9 N  822  PRO GLN CYS LEU LEU LEU LEU LEU ASP ALA PHE GLY LEU          
SEQRES  10 N  822  LEU GLU SER ARG LEU ASP PRO TYR LEU ARG SER LEU GLU          
SEQRES  11 N  822  LEU LEU GLU LYS TRP THR ARG LEU GLY LEU LEU MET GLY          
SEQRES  12 N  822  THR GLY ALA GLN GLY LEU ARG GLU GLU VAL HIS THR MET          
SEQRES  13 N  822  LEU ARG GLY VAL LEU PHE PHE SER THR PRO ARG THR PHE          
SEQRES  14 N  822  GLN GLU MET ILE GLN ARG LEU TYR GLY CYS PHE LEU ARG          
SEQRES  15 N  822  VAL TYR MET GLN SER LYS ARG LYS GLY GLU GLY GLY THR          
SEQRES  16 N  822  ASP PRO GLU LEU GLU GLY GLU LEU ASP SER ARG TYR ALA          
SEQRES  17 N  822  ARG ARG ARG TYR TYR ARG LEU LEU GLN SER PRO LEU CYS          
SEQRES  18 N  822  ALA GLY CYS SER SER ASP LYS GLN GLN CYS TRP CYS ARG          
SEQRES  19 N  822  GLN ALA LEU GLU GLN PHE HIS GLN LEU SER GLN VAL LEU          
SEQRES  20 N  822  HIS ARG LEU SER LEU LEU GLU ARG VAL SER ALA GLU ALA          
SEQRES  21 N  822  VAL THR THR THR LEU HIS GLN VAL THR ARG GLU ARG MET          
SEQRES  22 N  822  GLU ASP ARG CYS ARG GLY GLU TYR GLU ARG SER PHE LEU          
SEQRES  23 N  822  ARG GLU PHE HIS LYS TRP ILE GLU ARG VAL VAL GLY TRP          
SEQRES  24 N  822  LEU GLY LYS VAL PHE LEU GLN ASP GLY PRO ALA ARG PRO          
SEQRES  25 N  822  ALA SER PRO GLU ALA GLY ASN THR LEU ARG ARG TRP ARG          
SEQRES  26 N  822  CYS HIS VAL GLN ARG PHE PHE TYR ARG ILE TYR ALA SER          
SEQRES  27 N  822  LEU ARG ILE GLU GLU LEU PHE SER ILE VAL ARG ASP PHE          
SEQRES  28 N  822  PRO ASP SER ARG PRO ALA ILE GLU ASP LEU LYS TYR CYS          
SEQRES  29 N  822  LEU GLU ARG THR ASP GLN ARG GLN GLN LEU LEU VAL SER          
SEQRES  30 N  822  LEU LYS ALA ALA LEU GLU THR ARG LEU LEU HIS PRO GLY          
SEQRES  31 N  822  VAL ASN THR CYS ASP ILE ILE THR LEU TYR ILE SER ALA          
SEQRES  32 N  822  ILE LYS ALA LEU ARG VAL LEU ASP PRO SER MET VAL ILE          
SEQRES  33 N  822  LEU GLU VAL ALA CYS GLU PRO ILE ARG ARG TYR LEU ARG          
SEQRES  34 N  822  THR ARG GLU ASP THR VAL ARG GLN ILE VAL ALA GLY LEU          
SEQRES  35 N  822  THR GLY ASP SER ASP GLY THR GLY ASP LEU ALA VAL GLU          
SEQRES  36 N  822  LEU SER LYS THR ASP PRO ALA SER LEU GLU THR GLY GLN          
SEQRES  37 N  822  ASP SER GLU ASP ASP SER GLY GLU PRO GLU ASP TRP VAL          
SEQRES  38 N  822  PRO ASP PRO VAL ASP ALA ASP PRO GLY LYS SER SER SER          
SEQRES  39 N  822  LYS ARG ARG SER SER ASP ILE ILE SER LEU LEU VAL SER          
SEQRES  40 N  822  ILE TYR GLY SER LYS ASP LEU PHE ILE ASN GLU TYR ARG          
SEQRES  41 N  822  SER LEU LEU ALA ASP ARG LEU LEU HIS GLN PHE SER PHE          
SEQRES  42 N  822  SER PRO GLU ARG GLU ILE ARG ASN VAL GLU LEU LEU LYS          
SEQRES  43 N  822  LEU ARG PHE GLY GLU ALA PRO MET HIS PHE CYS GLU VAL          
SEQRES  44 N  822  MET LEU LYS ASP MET ALA ASP SER ARG ARG ILE ASN ALA          
SEQRES  45 N  822  ASN ILE ARG GLU GLU ASP GLU LYS ARG PRO ALA GLU GLU          
SEQRES  46 N  822  GLN PRO PRO PHE GLY VAL TYR ALA VAL ILE LEU SER SER          
SEQRES  47 N  822  GLU PHE TRP PRO PRO PHE LYS ASP GLU LYS LEU GLU VAL          
SEQRES  48 N  822  PRO GLU ASP ILE ARG ALA ALA LEU GLU ALA TYR CYS LYS          
SEQRES  49 N  822  LYS TYR GLU GLN LEU LYS ALA MET ARG THR LEU SER TRP          
SEQRES  50 N  822  LYS HIS THR LEU GLY LEU VAL THR MET ASP VAL GLU LEU          
SEQRES  51 N  822  ALA ASP ARG THR LEU SER VAL ALA VAL THR PRO VAL GLN          
SEQRES  52 N  822  ALA VAL ILE LEU LEU TYR PHE GLN ASP GLN ALA SER TRP          
SEQRES  53 N  822  THR LEU GLU GLU LEU SER LYS ALA VAL LYS MET PRO VAL          
SEQRES  54 N  822  ALA LEU LEU ARG ARG ARG MET SER VAL TRP LEU GLN GLN          
SEQRES  55 N  822  GLY VAL LEU ARG GLU GLU PRO PRO GLY THR PHE SER VAL          
SEQRES  56 N  822  ILE GLU GLU GLU ARG PRO GLN ASP ARG ASP ASN MET VAL          
SEQRES  57 N  822  LEU ILE ASP SER ASP ASP GLU SER ASP SER GLY MET ALA          
SEQRES  58 N  822  SER GLN ALA ASP GLN LYS GLU GLU GLU LEU LEU LEU PHE          
SEQRES  59 N  822  TRP THR TYR ILE GLN ALA MET LEU THR ASN LEU GLU SER          
SEQRES  60 N  822  LEU SER LEU ASP ARG ILE TYR ASN MET LEU ARG MET PHE          
SEQRES  61 N  822  VAL VAL THR GLY PRO ALA LEU ALA GLU ILE ASP LEU GLN          
SEQRES  62 N  822  GLU LEU GLN GLY TYR LEU GLN LYS LYS VAL ARG ASP GLN          
SEQRES  63 N  822  GLN LEU VAL TYR SER ALA GLY VAL TYR ARG LEU PRO LYS          
SEQRES  64 N  822  ASN CYS SER                                                  
SEQRES   1 O  755  MET ALA SER VAL HIS GLU SER LEU TYR PHE ASN PRO MET          
SEQRES   2 O  755  MET THR ASN GLY VAL VAL HIS ALA ASN VAL PHE GLY ILE          
SEQRES   3 O  755  LYS ASP TRP VAL THR PRO TYR LYS ILE ALA VAL LEU VAL          
SEQRES   4 O  755  LEU LEU ASN GLU MET SER ARG THR GLY GLU GLY ALA VAL          
SEQRES   5 O  755  SER LEU MET GLU ARG ARG ARG LEU ASN GLN LEU LEU LEU          
SEQRES   6 O  755  PRO LEU LEU GLN GLY PRO ASP ILE THR LEU SER LYS LEU          
SEQRES   7 O  755  TYR LYS LEU ILE GLU GLU SER CYS PRO GLN LEU ALA ASN          
SEQRES   8 O  755  SER VAL GLN ILE ARG ILE LYS LEU MET ALA GLU GLY GLU          
SEQRES   9 O  755  LEU LYS ASP MET GLU GLN PHE PHE ASP ASP LEU SER ASP          
SEQRES  10 O  755  SER PHE SER GLY THR GLU PRO GLU VAL HIS LYS THR SER          
SEQRES  11 O  755  VAL VAL GLY LEU PHE LEU ARG HIS MET ILE LEU ALA TYR          
SEQRES  12 O  755  SER LYS LEU SER PHE SER GLN VAL PHE LYS LEU TYR THR          
SEQRES  13 O  755  ALA LEU GLN GLN TYR PHE GLN ASN GLY GLU LYS LYS THR          
SEQRES  14 O  755  VAL GLU ASP ALA ASP MET GLU LEU THR SER ARG ASP GLU          
SEQRES  15 O  755  GLY GLU ARG LYS MET GLU LYS GLU GLU LEU ASP VAL SER          
SEQRES  16 O  755  VAL ARG GLU GLU GLU VAL SER CYS SER GLY PRO LEU SER          
SEQRES  17 O  755  GLN LYS GLN ALA GLU PHE PHE LEU SER GLN GLN ALA SER          
SEQRES  18 O  755  LEU LEU LYS ASN ASP GLU THR LYS ALA LEU THR PRO ALA          
SEQRES  19 O  755  SER LEU GLN LYS GLU LEU ASN ASN LEU LEU LYS PHE ASN          
SEQRES  20 O  755  PRO ASP PHE ALA GLU ALA HIS TYR LEU SER TYR LEU ASN          
SEQRES  21 O  755  ASN LEU ARG VAL GLN ASP VAL PHE SER SER THR HIS SER          
SEQRES  22 O  755  LEU LEU HIS TYR PHE ASP ARG LEU ILE LEU THR GLY ALA          
SEQRES  23 O  755  GLU SER LYS SER ASN GLY GLU GLU GLY TYR GLY ARG SER          
SEQRES  24 O  755  LEU ARG TYR ALA ALA LEU ASN LEU ALA ALA LEU HIS CYS          
SEQRES  25 O  755  ARG PHE GLY HIS TYR GLN GLN ALA GLU LEU ALA LEU GLN          
SEQRES  26 O  755  GLU ALA ILE ARG ILE ALA GLN GLU SER ASN ASP HIS VAL          
SEQRES  27 O  755  CYS LEU GLN HIS CYS LEU SER TRP LEU TYR VAL LEU GLY          
SEQRES  28 O  755  GLN LYS ARG SER ASP SER TYR VAL LEU LEU GLU HIS SER          
SEQRES  29 O  755  VAL LYS LYS ALA VAL HIS PHE GLY LEU PRO TYR LEU ALA          
SEQRES  30 O  755  SER LEU GLY ILE GLN SER LEU VAL GLN GLN ARG ALA PHE          
SEQRES  31 O  755  ALA GLY LYS THR ALA ASN LYS LEU MET ASP ALA LEU LYS          
SEQRES  32 O  755  ASP SER ASP LEU LEU HIS TRP LYS HIS SER LEU SER GLU          
SEQRES  33 O  755  LEU ILE ASP ILE SER ILE ALA GLN LYS THR ALA ILE TRP          
SEQRES  34 O  755  ARG LEU TYR GLY ARG SER THR MET ALA LEU GLN GLN ALA          
SEQRES  35 O  755  GLN MET LEU LEU SER MET ASN SER LEU GLU ALA VAL ASN          
SEQRES  36 O  755  ALA GLY VAL GLN GLN ASN ASN THR GLU SER PHE ALA VAL          
SEQRES  37 O  755  ALA LEU CYS HIS LEU ALA GLU LEU HIS ALA GLU GLN GLY          
SEQRES  38 O  755  CYS PHE ALA ALA ALA SER GLU VAL LEU LYS HIS LEU LYS          
SEQRES  39 O  755  GLU ARG PHE PRO PRO ASN SER GLN HIS ALA GLN LEU TRP          
SEQRES  40 O  755  MET LEU CYS ASP GLN LYS ILE GLN PHE ASP ARG ALA MET          
SEQRES  41 O  755  ASN ASP GLY LYS TYR HIS LEU ALA ASP SER LEU VAL THR          
SEQRES  42 O  755  GLY ILE THR ALA LEU ASN SER ILE GLU GLY VAL TYR ARG          
SEQRES  43 O  755  LYS ALA VAL VAL LEU GLN ALA GLN ASN GLN MET SER GLU          
SEQRES  44 O  755  ALA HIS LYS LEU LEU GLN LYS LEU LEU VAL HIS CYS GLN          
SEQRES  45 O  755  LYS LEU LYS ASN THR GLU MET VAL ILE SER VAL LEU LEU          
SEQRES  46 O  755  SER VAL ALA GLU LEU TYR TRP ARG SER SER SER PRO THR          
SEQRES  47 O  755  ILE ALA LEU PRO MET LEU LEU GLN ALA LEU ALA LEU SER          
SEQRES  48 O  755  LYS GLU TYR ARG LEU GLN TYR LEU ALA SER GLU THR VAL          
SEQRES  49 O  755  LEU ASN LEU ALA PHE ALA GLN LEU ILE LEU GLY ILE PRO          
SEQRES  50 O  755  GLU GLN ALA LEU SER LEU LEU HIS MET ALA ILE GLU PRO          
SEQRES  51 O  755  ILE LEU ALA ASP GLY ALA ILE LEU ASP LYS GLY ARG ALA          
SEQRES  52 O  755  MET PHE LEU VAL ALA LYS CYS GLN VAL ALA SER ALA ALA          
SEQRES  53 O  755  SER TYR ASP GLN PRO LYS LYS ALA GLU ALA LEU GLU ALA          
SEQRES  54 O  755  ALA ILE GLU ASN LEU ASN GLU ALA LYS ASN TYR PHE ALA          
SEQRES  55 O  755  LYS VAL ASP CYS LYS GLU ARG ILE ARG ASP VAL VAL TYR          
SEQRES  56 O  755  PHE GLN ALA ARG LEU TYR HIS THR LEU GLY LYS THR GLN          
SEQRES  57 O  755  GLU ARG ASN ARG CYS ALA MET LEU PHE ARG GLN LEU HIS          
SEQRES  58 O  755  GLN GLU LEU PRO SER HIS GLY VAL PRO LEU ILE ASN HIS          
SEQRES  59 O  755  LEU                                                          
SEQRES   1 P  597  MET ALA ALA SER THR SER MET VAL PRO VAL ALA VAL THR          
SEQRES   2 P  597  ALA ALA VAL ALA PRO VAL LEU SER ILE ASN SER ASP PHE          
SEQRES   3 P  597  SER ASP LEU ARG GLU ILE LYS LYS GLN LEU LEU LEU ILE          
SEQRES   4 P  597  ALA GLY LEU THR ARG GLU ARG GLY LEU LEU HIS SER SER          
SEQRES   5 P  597  LYS TRP SER ALA GLU LEU ALA PHE SER LEU PRO ALA LEU          
SEQRES   6 P  597  PRO LEU ALA GLU LEU GLN PRO PRO PRO PRO ILE THR GLU          
SEQRES   7 P  597  GLU ASP ALA GLN ASP MET ASP ALA TYR THR LEU ALA LYS          
SEQRES   8 P  597  ALA TYR PHE ASP VAL LYS GLU TYR ASP ARG ALA ALA HIS          
SEQRES   9 P  597  PHE LEU HIS GLY CYS ASN SER LYS LYS ALA TYR PHE LEU          
SEQRES  10 P  597  TYR MET TYR SER ARG TYR LEU SER GLY GLU LYS LYS LYS          
SEQRES  11 P  597  ASP ASP GLU THR VAL ASP SER LEU GLY PRO LEU GLU LYS          
SEQRES  12 P  597  GLY GLN VAL LYS ASN GLU ALA LEU ARG GLU LEU ARG VAL          
SEQRES  13 P  597  GLU LEU SER LYS LYS HIS GLN ALA ARG GLU LEU ASP GLY          
SEQRES  14 P  597  PHE GLY LEU TYR LEU TYR GLY VAL VAL LEU ARG LYS LEU          
SEQRES  15 P  597  ASP LEU VAL LYS GLU ALA ILE ASP VAL PHE VAL GLU ALA          
SEQRES  16 P  597  THR HIS VAL LEU PRO LEU HIS TRP GLY ALA TRP LEU GLU          
SEQRES  17 P  597  LEU CYS ASN LEU ILE THR ASP LYS GLU MET LEU LYS PHE          
SEQRES  18 P  597  LEU SER LEU PRO ASP THR TRP MET LYS GLU PHE PHE LEU          
SEQRES  19 P  597  ALA HIS ILE TYR THR GLU LEU GLN LEU ILE GLU GLU ALA          
SEQRES  20 P  597  LEU GLN LYS TYR GLN ASN LEU ILE ASP VAL GLY PHE SER          
SEQRES  21 P  597  LYS SER SER TYR ILE VAL SER GLN ILE ALA VAL ALA TYR          
SEQRES  22 P  597  HIS ASN ILE ARG ASP ILE ASP LYS ALA LEU SER ILE PHE          
SEQRES  23 P  597  ASN GLU LEU ARG LYS GLN ASP PRO TYR ARG ILE GLU ASN          
SEQRES  24 P  597  MET ASP THR PHE SER ASN LEU LEU TYR VAL ARG SER MET          
SEQRES  25 P  597  LYS SER GLU LEU SER TYR LEU ALA HIS ASN LEU CYS GLU          
SEQRES  26 P  597  ILE ASP LYS TYR ARG VAL GLU THR CYS CYS VAL ILE GLY          
SEQRES  27 P  597  ASN TYR TYR SER LEU ARG SER GLN HIS GLU LYS ALA ALA          
SEQRES  28 P  597  LEU TYR PHE GLN ARG ALA LEU LYS LEU ASN PRO ARG TYR          
SEQRES  29 P  597  LEU GLY ALA TRP THR LEU MET GLY HIS GLU TYR MET GLU          
SEQRES  30 P  597  MET LYS ASN THR SER ALA ALA ILE GLN ALA TYR ARG HIS          
SEQRES  31 P  597  ALA ILE GLU VAL ASN LYS ARG ASP TYR ARG ALA TRP TYR          
SEQRES  32 P  597  GLY LEU GLY GLN THR TYR GLU ILE LEU LYS MET PRO PHE          
SEQRES  33 P  597  TYR CYS LEU TYR TYR TYR ARG ARG ALA HIS GLN LEU ARG          
SEQRES  34 P  597  PRO ASN ASP SER ARG MET LEU VAL ALA LEU GLY GLU CYS          
SEQRES  35 P  597  TYR GLU LYS LEU ASN GLN LEU VAL GLU ALA LYS LYS CYS          
SEQRES  36 P  597  TYR TRP ARG ALA TYR ALA VAL GLY ASP VAL GLU LYS MET          
SEQRES  37 P  597  ALA LEU VAL LYS LEU ALA LYS LEU HIS GLU GLN LEU THR          
SEQRES  38 P  597  GLU SER GLU GLN ALA ALA GLN CYS TYR ILE LYS TYR ILE          
SEQRES  39 P  597  GLN ASP ILE TYR SER CYS GLY GLU ILE VAL GLU HIS LEU          
SEQRES  40 P  597  GLU GLU SER THR ALA PHE ARG TYR LEU ALA GLN TYR TYR          
SEQRES  41 P  597  PHE LYS CYS LYS LEU TRP ASP GLU ALA SER THR CYS ALA          
SEQRES  42 P  597  GLN LYS CYS CYS ALA PHE ASN ASP THR ARG GLU GLU GLY          
SEQRES  43 P  597  LYS ALA LEU LEU ARG GLN ILE LEU GLN LEU ARG ASN GLN          
SEQRES  44 P  597  GLY GLU THR PRO THR THR GLU VAL PRO ALA PRO PHE PHE          
SEQRES  45 P  597  LEU PRO ALA SER LEU SER ALA ASN ASN THR PRO THR ARG          
SEQRES  46 P  597  ARG VAL SER PRO LEU ASN LEU SER SER VAL THR PRO              
SEQRES   1 T   15  ALA ALA ALA ALA ALA GLN LEU ALA ALA ALA ALA ALA ALA          
SEQRES   2 T   15  ALA ALA                                                      
SEQRES   1 W   85  MET LEU ARG ARG LYS PRO THR ARG LEU GLU LEU LYS LEU          
SEQRES   2 W   85  ASP ASP ILE GLU GLU PHE GLU ASN ILE ARG LYS ASP LEU          
SEQRES   3 W   85  GLU THR ARG LYS LYS GLN LYS GLU ASP VAL GLU VAL VAL          
SEQRES   4 W   85  GLY GLY SER ASP GLY GLU GLY ALA ILE GLY LEU SER SER          
SEQRES   5 W   85  ASP PRO LYS SER ARG GLU GLN MET ILE ASN ASP ARG ILE          
SEQRES   6 W   85  GLY TYR LYS PRO GLN PRO LYS PRO ASN ASN ARG SER SER          
SEQRES   7 W   85  GLN PHE GLY SER LEU GLU PHE                                  
SEQRES   1 X  599  MET ASP PRO GLY ASP ALA ALA ILE LEU GLU SER SER LEU          
SEQRES   2 X  599  ARG ILE LEU TYR ARG LEU PHE GLU SER VAL LEU PRO PRO          
SEQRES   3 X  599  LEU PRO ALA ALA LEU GLN SER ARG MET ASN VAL ILE ASP          
SEQRES   4 X  599  HIS VAL ARG ASP MET ALA ALA ALA GLY LEU HIS SER ASN          
SEQRES   5 X  599  VAL ARG LEU LEU SER SER LEU LEU LEU THR MET SER ASN          
SEQRES   6 X  599  ASN ASN PRO GLU LEU PHE SER PRO PRO GLN LYS TYR GLN          
SEQRES   7 X  599  LEU LEU VAL TYR HIS ALA ASP SER LEU PHE HIS ASP LYS          
SEQRES   8 X  599  GLU TYR ARG ASN ALA VAL SER LYS TYR THR MET ALA LEU          
SEQRES   9 X  599  GLN GLN LYS LYS ALA LEU SER LYS THR SER LYS VAL ARG          
SEQRES  10 X  599  PRO SER THR GLY ASN SER ALA SER THR PRO GLN SER GLN          
SEQRES  11 X  599  CYS LEU PRO SER GLU ILE GLU VAL LYS TYR LYS MET ALA          
SEQRES  12 X  599  GLU CYS TYR THR MET LEU LYS GLN ASP LYS ASP ALA ILE          
SEQRES  13 X  599  ALA ILE LEU ASP GLY ILE PRO SER ARG GLN ARG THR PRO          
SEQRES  14 X  599  LYS ILE ASN MET MET LEU ALA ASN LEU TYR LYS LYS ALA          
SEQRES  15 X  599  GLY GLN GLU ARG PRO SER VAL THR SER TYR LYS GLU VAL          
SEQRES  16 X  599  LEU ARG GLN CYS PRO LEU ALA LEU ASP ALA ILE LEU GLY          
SEQRES  17 X  599  LEU LEU SER LEU SER VAL LYS GLY ALA GLU VAL ALA SER          
SEQRES  18 X  599  MET THR MET ASN VAL ILE GLN THR VAL PRO ASN LEU ASP          
SEQRES  19 X  599  TRP LEU SER VAL TRP ILE LYS ALA TYR ALA PHE VAL HIS          
SEQRES  20 X  599  THR GLY ASP ASN SER ARG ALA ILE SER THR ILE CYS SER          
SEQRES  21 X  599  LEU GLU LYS LYS SER LEU LEU ARG ASP ASN VAL ASP LEU          
SEQRES  22 X  599  LEU GLY SER LEU ALA ASP LEU TYR PHE ARG ALA GLY ASP          
SEQRES  23 X  599  ASN LYS ASN SER VAL LEU LYS PHE GLU GLN ALA GLN MET          
SEQRES  24 X  599  LEU ASP PRO TYR LEU ILE LYS GLY MET ASP VAL TYR GLY          
SEQRES  25 X  599  TYR LEU LEU ALA ARG GLU GLY ARG LEU GLU ASP VAL GLU          
SEQRES  26 X  599  ASN LEU GLY CYS ARG LEU PHE ASN ILE SER ASP GLN HIS          
SEQRES  27 X  599  ALA GLU PRO TRP VAL VAL SER GLY CYS HIS SER PHE TYR          
SEQRES  28 X  599  SER LYS ARG TYR SER ARG ALA LEU TYR LEU GLY ALA LYS          
SEQRES  29 X  599  ALA ILE GLN LEU ASN SER ASN SER VAL GLN ALA LEU LEU          
SEQRES  30 X  599  LEU LYS GLY ALA ALA LEU ARG ASN MET GLY ARG VAL GLN          
SEQRES  31 X  599  GLU ALA ILE ILE HIS PHE ARG GLU ALA ILE ARG LEU ALA          
SEQRES  32 X  599  PRO CYS ARG LEU ASP CYS TYR GLU GLY LEU ILE GLU CYS          
SEQRES  33 X  599  TYR LEU ALA SER ASN SER ILE ARG GLU ALA MET VAL MET          
SEQRES  34 X  599  ALA ASN ASN VAL TYR LYS THR LEU GLY ALA ASN ALA GLN          
SEQRES  35 X  599  THR LEU THR LEU LEU ALA THR VAL CYS LEU GLU ASP PRO          
SEQRES  36 X  599  VAL THR GLN GLU LYS ALA LYS THR LEU LEU ASP LYS ALA          
SEQRES  37 X  599  LEU THR GLN ARG PRO ASP TYR ILE LYS ALA VAL VAL LYS          
SEQRES  38 X  599  LYS ALA GLU LEU LEU SER ARG GLU GLN LYS TYR GLU ASP          
SEQRES  39 X  599  GLY ILE ALA LEU LEU ARG ASN ALA LEU ALA ASN GLN SER          
SEQRES  40 X  599  ASP CYS VAL LEU HIS ARG ILE LEU GLY ASP PHE LEU VAL          
SEQRES  41 X  599  ALA VAL ASN GLU TYR GLN GLU ALA MET ASP GLN TYR SER          
SEQRES  42 X  599  ILE ALA LEU SER LEU ASP PRO ASN ASP GLN LYS SER LEU          
SEQRES  43 X  599  GLU GLY MET GLN LYS MET GLU LYS GLU GLU SER PRO THR          
SEQRES  44 X  599  ASP ALA THR GLN GLU GLU ASP VAL ASP ASP MET GLU GLY          
SEQRES  45 X  599  SER GLY GLU GLU GLY ASP LEU GLU GLY SER ASP SER GLU          
SEQRES  46 X  599  ALA ALA GLN TRP ALA ASP GLN GLU GLN TRP PHE GLY MET          
SEQRES  47 X  599  GLN                                                          
SEQRES   1 Y  599  MET ASP PRO GLY ASP ALA ALA ILE LEU GLU SER SER LEU          
SEQRES   2 Y  599  ARG ILE LEU TYR ARG LEU PHE GLU SER VAL LEU PRO PRO          
SEQRES   3 Y  599  LEU PRO ALA ALA LEU GLN SER ARG MET ASN VAL ILE ASP          
SEQRES   4 Y  599  HIS VAL ARG ASP MET ALA ALA ALA GLY LEU HIS SER ASN          
SEQRES   5 Y  599  VAL ARG LEU LEU SER SER LEU LEU LEU THR MET SER ASN          
SEQRES   6 Y  599  ASN ASN PRO GLU LEU PHE SER PRO PRO GLN LYS TYR GLN          
SEQRES   7 Y  599  LEU LEU VAL TYR HIS ALA ASP SER LEU PHE HIS ASP LYS          
SEQRES   8 Y  599  GLU TYR ARG ASN ALA VAL SER LYS TYR THR MET ALA LEU          
SEQRES   9 Y  599  GLN GLN LYS LYS ALA LEU SER LYS THR SER LYS VAL ARG          
SEQRES  10 Y  599  PRO SER THR GLY ASN SER ALA SER THR PRO GLN SER GLN          
SEQRES  11 Y  599  CYS LEU PRO SER GLU ILE GLU VAL LYS TYR LYS MET ALA          
SEQRES  12 Y  599  GLU CYS TYR THR MET LEU LYS GLN ASP LYS ASP ALA ILE          
SEQRES  13 Y  599  ALA ILE LEU ASP GLY ILE PRO SER ARG GLN ARG THR PRO          
SEQRES  14 Y  599  LYS ILE ASN MET MET LEU ALA ASN LEU TYR LYS LYS ALA          
SEQRES  15 Y  599  GLY GLN GLU ARG PRO SER VAL THR SER TYR LYS GLU VAL          
SEQRES  16 Y  599  LEU ARG GLN CYS PRO LEU ALA LEU ASP ALA ILE LEU GLY          
SEQRES  17 Y  599  LEU LEU SER LEU SER VAL LYS GLY ALA GLU VAL ALA SER          
SEQRES  18 Y  599  MET THR MET ASN VAL ILE GLN THR VAL PRO ASN LEU ASP          
SEQRES  19 Y  599  TRP LEU SER VAL TRP ILE LYS ALA TYR ALA PHE VAL HIS          
SEQRES  20 Y  599  THR GLY ASP ASN SER ARG ALA ILE SER THR ILE CYS SER          
SEQRES  21 Y  599  LEU GLU LYS LYS SER LEU LEU ARG ASP ASN VAL ASP LEU          
SEQRES  22 Y  599  LEU GLY SER LEU ALA ASP LEU TYR PHE ARG ALA GLY ASP          
SEQRES  23 Y  599  ASN LYS ASN SER VAL LEU LYS PHE GLU GLN ALA GLN MET          
SEQRES  24 Y  599  LEU ASP PRO TYR LEU ILE LYS GLY MET ASP VAL TYR GLY          
SEQRES  25 Y  599  TYR LEU LEU ALA ARG GLU GLY ARG LEU GLU ASP VAL GLU          
SEQRES  26 Y  599  ASN LEU GLY CYS ARG LEU PHE ASN ILE SER ASP GLN HIS          
SEQRES  27 Y  599  ALA GLU PRO TRP VAL VAL SER GLY CYS HIS SER PHE TYR          
SEQRES  28 Y  599  SER LYS ARG TYR SER ARG ALA LEU TYR LEU GLY ALA LYS          
SEQRES  29 Y  599  ALA ILE GLN LEU ASN SER ASN SER VAL GLN ALA LEU LEU          
SEQRES  30 Y  599  LEU LYS GLY ALA ALA LEU ARG ASN MET GLY ARG VAL GLN          
SEQRES  31 Y  599  GLU ALA ILE ILE HIS PHE ARG GLU ALA ILE ARG LEU ALA          
SEQRES  32 Y  599  PRO CYS ARG LEU ASP CYS TYR GLU GLY LEU ILE GLU CYS          
SEQRES  33 Y  599  TYR LEU ALA SER ASN SER ILE ARG GLU ALA MET VAL MET          
SEQRES  34 Y  599  ALA ASN ASN VAL TYR LYS THR LEU GLY ALA ASN ALA GLN          
SEQRES  35 Y  599  THR LEU THR LEU LEU ALA THR VAL CYS LEU GLU ASP PRO          
SEQRES  36 Y  599  VAL THR GLN GLU LYS ALA LYS THR LEU LEU ASP LYS ALA          
SEQRES  37 Y  599  LEU THR GLN ARG PRO ASP TYR ILE LYS ALA VAL VAL LYS          
SEQRES  38 Y  599  LYS ALA GLU LEU LEU SER ARG GLU GLN LYS TYR GLU ASP          
SEQRES  39 Y  599  GLY ILE ALA LEU LEU ARG ASN ALA LEU ALA ASN GLN SER          
SEQRES  40 Y  599  ASP CYS VAL LEU HIS ARG ILE LEU GLY ASP PHE LEU VAL          
SEQRES  41 Y  599  ALA VAL ASN GLU TYR GLN GLU ALA MET ASP GLN TYR SER          
SEQRES  42 Y  599  ILE ALA LEU SER LEU ASP PRO ASN ASP GLN LYS SER LEU          
SEQRES  43 Y  599  GLU GLY MET GLN LYS MET GLU LYS GLU GLU SER PRO THR          
SEQRES  44 Y  599  ASP ALA THR GLN GLU GLU ASP VAL ASP ASP MET GLU GLY          
SEQRES  45 Y  599  SER GLY GLU GLU GLY ASP LEU GLU GLY SER ASP SER GLU          
SEQRES  46 Y  599  ALA ALA GLN TRP ALA ASP GLN GLU GLN TRP PHE GLY MET          
SEQRES  47 Y  599  GLN                                                          
SEQRES   1 S  445  MET PRO SER ARG ALA GLU ASP TYR GLU VAL LEU TYR THR          
SEQRES   2 S  445  ILE GLY THR GLY SER TYR GLY ARG CYS GLN LYS ILE ARG          
SEQRES   3 S  445  ARG LYS SER ASP GLY LYS ILE LEU VAL TRP LYS GLU LEU          
SEQRES   4 S  445  ASP TYR GLY SER MET THR GLU ALA GLU LYS GLN MET LEU          
SEQRES   5 S  445  VAL SER GLU VAL ASN LEU LEU ARG GLU LEU LYS HIS PRO          
SEQRES   6 S  445  ASN ILE VAL ARG TYR TYR ASP ARG ILE ILE ASP ARG THR          
SEQRES   7 S  445  ASN THR THR LEU TYR ILE VAL MET GLU TYR CYS GLU GLY          
SEQRES   8 S  445  GLY ASP LEU ALA SER VAL ILE THR LYS GLY THR LYS GLU          
SEQRES   9 S  445  ARG GLN TYR LEU ASP GLU GLU PHE VAL LEU ARG VAL MET          
SEQRES  10 S  445  THR GLN LEU THR LEU ALA LEU LYS GLU CYS HIS ARG ARG          
SEQRES  11 S  445  SER ASP GLY GLY HIS THR VAL LEU HIS ARG ASP LEU LYS          
SEQRES  12 S  445  PRO ALA ASN VAL PHE LEU ASP GLY LYS GLN ASN VAL LYS          
SEQRES  13 S  445  LEU GLY ASP PHE GLY LEU ALA ARG ILE LEU ASN HIS ASP          
SEQRES  14 S  445  THR SER PHE ALA LYS THR PHE VAL GLY THR PRO TYR TYR          
SEQRES  15 S  445  MET SER PRO GLU GLN MET ASN ARG MET SER TYR ASN GLU          
SEQRES  16 S  445  LYS SER ASP ILE TRP SER LEU GLY CYS LEU LEU TYR GLU          
SEQRES  17 S  445  LEU CYS ALA LEU MET PRO PRO PHE THR ALA PHE SER GLN          
SEQRES  18 S  445  LYS GLU LEU ALA GLY LYS ILE ARG GLU GLY LYS PHE ARG          
SEQRES  19 S  445  ARG ILE PRO TYR ARG TYR SER ASP GLU LEU ASN GLU ILE          
SEQRES  20 S  445  ILE THR ARG MET LEU ASN LEU LYS ASP TYR HIS ARG PRO          
SEQRES  21 S  445  SER VAL GLU GLU ILE LEU GLU ASN PRO LEU ILE ALA ASP          
SEQRES  22 S  445  LEU VAL ALA ASP GLU GLN ARG ARG ASN LEU GLU ARG ARG          
SEQRES  23 S  445  GLY ARG GLN LEU GLY GLU PRO GLU LYS SER GLN ASP SER          
SEQRES  24 S  445  SER PRO VAL LEU SER GLU LEU LYS LEU LYS GLU ILE GLN          
SEQRES  25 S  445  LEU GLN GLU ARG GLU ARG ALA LEU LYS ALA ARG GLU GLU          
SEQRES  26 S  445  ARG LEU GLU GLN LYS GLU GLN GLU LEU CYS VAL ARG GLU          
SEQRES  27 S  445  ARG LEU ALA GLU ASP LYS LEU ALA ARG ALA GLU ASN LEU          
SEQRES  28 S  445  LEU LYS ASN TYR SER LEU LEU LYS GLU ARG LYS PHE LEU          
SEQRES  29 S  445  SER LEU ALA SER ASN PRO GLU LEU LEU ASN LEU PRO SER          
SEQRES  30 S  445  SER VAL ILE LYS LYS LYS VAL HIS PHE SER GLY GLU SER          
SEQRES  31 S  445  LYS GLU ASN ILE ALA ARG SER GLU ASN SER GLU SER GLN          
SEQRES  32 S  445  LEU THR SER LYS SER LYS CYS LYS ASP LEU LYS LYS ARG          
SEQRES  33 S  445  LEU HIS ALA ALA GLN LEU ARG ALA GLN ALA LEU SER ASP          
SEQRES  34 S  445  ILE GLU LYS ASN TYR GLN LEU LYS SER ARG GLN ILE LEU          
SEQRES  35 S  445  GLY MET ARG                                                  
SEQRES   1 Q  445  MET PRO SER ARG ALA GLU ASP TYR GLU VAL LEU TYR THR          
SEQRES   2 Q  445  ILE GLY THR GLY SER TYR GLY ARG CYS GLN LYS ILE ARG          
SEQRES   3 Q  445  ARG LYS SER ASP GLY LYS ILE LEU VAL TRP LYS GLU LEU          
SEQRES   4 Q  445  ASP TYR GLY SER MET THR GLU ALA GLU LYS GLN MET LEU          
SEQRES   5 Q  445  VAL SER GLU VAL ASN LEU LEU ARG GLU LEU LYS HIS PRO          
SEQRES   6 Q  445  ASN ILE VAL ARG TYR TYR ASP ARG ILE ILE ASP ARG THR          
SEQRES   7 Q  445  ASN THR THR LEU TYR ILE VAL MET GLU TYR CYS GLU GLY          
SEQRES   8 Q  445  GLY ASP LEU ALA SER VAL ILE THR LYS GLY THR LYS GLU          
SEQRES   9 Q  445  ARG GLN TYR LEU ASP GLU GLU PHE VAL LEU ARG VAL MET          
SEQRES  10 Q  445  THR GLN LEU THR LEU ALA LEU LYS GLU CYS HIS ARG ARG          
SEQRES  11 Q  445  SER ASP GLY GLY HIS THR VAL LEU HIS ARG ASP LEU LYS          
SEQRES  12 Q  445  PRO ALA ASN VAL PHE LEU ASP GLY LYS GLN ASN VAL LYS          
SEQRES  13 Q  445  LEU GLY ASP PHE GLY LEU ALA ARG ILE LEU ASN HIS ASP          
SEQRES  14 Q  445  THR SER PHE ALA LYS THR PHE VAL GLY THR PRO TYR TYR          
SEQRES  15 Q  445  MET SER PRO GLU GLN MET ASN ARG MET SER TYR ASN GLU          
SEQRES  16 Q  445  LYS SER ASP ILE TRP SER LEU GLY CYS LEU LEU TYR GLU          
SEQRES  17 Q  445  LEU CYS ALA LEU MET PRO PRO PHE THR ALA PHE SER GLN          
SEQRES  18 Q  445  LYS GLU LEU ALA GLY LYS ILE ARG GLU GLY LYS PHE ARG          
SEQRES  19 Q  445  ARG ILE PRO TYR ARG TYR SER ASP GLU LEU ASN GLU ILE          
SEQRES  20 Q  445  ILE THR ARG MET LEU ASN LEU LYS ASP TYR HIS ARG PRO          
SEQRES  21 Q  445  SER VAL GLU GLU ILE LEU GLU ASN PRO LEU ILE ALA ASP          
SEQRES  22 Q  445  LEU VAL ALA ASP GLU GLN ARG ARG ASN LEU GLU ARG ARG          
SEQRES  23 Q  445  GLY ARG GLN LEU GLY GLU PRO GLU LYS SER GLN ASP SER          
SEQRES  24 Q  445  SER PRO VAL LEU SER GLU LEU LYS LEU LYS GLU ILE GLN          
SEQRES  25 Q  445  LEU GLN GLU ARG GLU ARG ALA LEU LYS ALA ARG GLU GLU          
SEQRES  26 Q  445  ARG LEU GLU GLN LYS GLU GLN GLU LEU CYS VAL ARG GLU          
SEQRES  27 Q  445  ARG LEU ALA GLU ASP LYS LEU ALA ARG ALA GLU ASN LEU          
SEQRES  28 Q  445  LEU LYS ASN TYR SER LEU LEU LYS GLU ARG LYS PHE LEU          
SEQRES  29 Q  445  SER LEU ALA SER ASN PRO GLU LEU LEU ASN LEU PRO SER          
SEQRES  30 Q  445  SER VAL ILE LYS LYS LYS VAL HIS PHE SER GLY GLU SER          
SEQRES  31 Q  445  LYS GLU ASN ILE MET ARG SER GLU ASN SER GLU SER GLN          
SEQRES  32 Q  445  LEU THR SER LYS SER LYS CYS LYS ASP LEU LYS LYS ARG          
SEQRES  33 Q  445  LEU HIS ALA ALA GLN LEU ARG ALA GLN ALA LEU SER ASP          
SEQRES  34 Q  445  ILE GLU LYS ASN TYR GLN LEU LYS SER ARG GLN ILE LEU          
SEQRES  35 Q  445  GLY MET ARG                                                  
HET     ZN  B 101       1                                                       
HET     ZN  B 102       1                                                       
HET     ZN  B 103       1                                                       
HETNAM      ZN ZINC ION                                                         
FORMUL  23   ZN    3(ZN 2+)                                                     
HELIX    1 AA1 PRO A   22  LYS A   29  1                                   8    
HELIX    2 AA2 SER A  615  LEU A  629  1                                  15    
HELIX    3 AA3 PRO A  630  ALA A  647  1                                  18    
HELIX    4 AA4 SER A  655  ASN A  666  1                                  12    
HELIX    5 AA5 ASP A  673  TRP A  677  5                                   5    
HELIX    6 AA6 ASP A  705  SER A  713  1                                   9    
HELIX    7 AA7 SER A  713  HIS A  722  1                                  10    
HELIX    8 AA8 HIS A  758  THR A  777  1                                  20    
HELIX    9 AA9 GLY A  782  LYS A  798  1                                  17    
HELIX   10 AB1 GLY A  800  TYR A  810  1                                  11    
HELIX   11 AB2 PRO A  811  VAL A  814  5                                   4    
HELIX   12 AB3 SER A  843  LYS A  853  1                                  11    
HELIX   13 AB4 CYS A  867  ILE A  881  1                                  15    
HELIX   14 AB5 ALA A  927  VAL A  937  1                                  11    
HELIX   15 AB6 THR A  940  GLU A  945  1                                   6    
HELIX   16 AB7 PRO A  948  GLN A  965  1                                  18    
HELIX   17 AB8 PRO A  971  ILE A  978  1                                   8    
HELIX   18 AB9 ARG A  980  LEU A  992  1                                  13    
HELIX   19 AC1 ASN A 1020  TRP A 1028  1                                   9    
HELIX   20 AC2 LEU A 1032  GLN A 1042  1                                  11    
HELIX   21 AC3 SER A 1058  MET A 1078  1                                  21    
HELIX   22 AC4 ALA A 1079  THR A 1088  1                                  10    
HELIX   23 AC5 THR A 1132  LYS A 1146  1                                  15    
HELIX   24 AC6 LEU A 1168  ASN A 1182  1                                  15    
HELIX   25 AC7 ILE A 1193  GLY A 1200  1                                   8    
HELIX   26 AC8 HIS A 1201  LEU A 1217  1                                  17    
HELIX   27 AC9 ASP A 1221  ILE A 1232  1                                  12    
HELIX   28 AD1 PRO A 1246  GLN A 1262  1                                  17    
HELIX   29 AD2 HIS A 1266  GLY A 1278  1                                  13    
HELIX   30 AD3 ASP A 1290  LEU A 1307  1                                  18    
HELIX   31 AD4 ASN A 1320  GLY A 1331  1                                  12    
HELIX   32 AD5 ASN A 1359  TYR A 1375  1                                  17    
HELIX   33 AD6 ASN A 1380  TRP A 1386  1                                   7    
HELIX   34 AD7 LEU A 1395  VAL A 1399  5                                   5    
HELIX   35 AD8 LYS A 1400  LEU A 1415  1                                  16    
HELIX   36 AD9 ASN A 1422  SER A 1428  1                                   7    
HELIX   37 AE1 PRO A 1431  ASN A 1437  1                                   7    
HELIX   38 AE2 THR A 1456  ARG A 1475  1                                  20    
HELIX   39 AE3 ASN A 1481  ALA A 1501  1                                  21    
HELIX   40 AE4 ASN A 1503  GLY A 1508  1                                   6    
HELIX   41 AE5 GLY A 1508  MET A 1527  1                                  20    
HELIX   42 AE6 ASN A 1532  LYS A 1545  1                                  14    
HELIX   43 AE7 ASN A 1551  PHE A 1566  1                                  16    
HELIX   44 AE8 LEU A 1567  GLY A 1570  5                                   4    
HELIX   45 AE9 SER A 1579  LEU A 1588  1                                  10    
HELIX   46 AF1 LEU A 1603  ALA A 1613  5                                  11    
HELIX   47 AF2 VAL A 1624  ASN A 1627  5                                   4    
HELIX   48 AF3 GLN A 1685  LEU A 1691  1                                   7    
HELIX   49 AF4 LYS A 1734  ALA A 1740  5                                   7    
HELIX   50 AF5 ASP A 1744  CYS A 1755  1                                  12    
HELIX   51 AF6 LYS A 1764  GLN A 1781  1                                  18    
HELIX   52 AF7 MET A 1786  ARG A 1802  1                                  17    
HELIX   53 AF8 THR A 1808  PHE A 1821  1                                  14    
HELIX   54 AF9 SER A 1822  GLU A 1828  5                                   7    
HELIX   55 AG1 PHE A 1844  GLY A 1863  1                                  20    
HELIX   56 AG2 GLY A 1864  SER A 1873  1                                  10    
HELIX   57 AG3 SER A 1880  SER A 1893  1                                  14    
HELIX   58 AG4 ALA A 1912  LEU A 1921  1                                  10    
HELIX   59 AG5 PRO A 1924  ALA A 1932  1                                   9    
HELIX   60 AG6 PRO B   40  CYS B   44  5                                   5    
HELIX   61 AG7 MET B   57  GLN B   68  1                                  12    
HELIX   62 AG8 ASP C   28  GLY C   47  1                                  20    
HELIX   63 AG9 LEU C   48  LEU C   62  1                                  15    
HELIX   64 AH1 THR C   77  ASP C   95  1                                  19    
HELIX   65 AH2 GLU C   98  HIS C  107  1                                  10    
HELIX   66 AH3 SER C  111  SER C  137  1                                  27    
HELIX   67 AH4 ALA C  150  ALA C  164  1                                  15    
HELIX   68 AH5 GLY C  169  LEU C  182  1                                  14    
HELIX   69 AH6 LEU C  184  LEU C  199  1                                  16    
HELIX   70 AH7 HIS C  202  ASN C  211  1                                  10    
HELIX   71 AH8 ASP C  215  LEU C  222  1                                   8    
HELIX   72 AH9 TRP C  228  LEU C  241  1                                  14    
HELIX   73 AI1 LEU C  243  VAL C  257  1                                  15    
HELIX   74 AI2 GLY C  258  SER C  262  5                                   5    
HELIX   75 AI3 SER C  263  ILE C  276  1                                  14    
HELIX   76 AI4 ILE C  279  ASP C  293  1                                  15    
HELIX   77 AI5 ASN C  299  ARG C  310  1                                  12    
HELIX   78 AI6 MET C  312  ASP C  327  1                                  16    
HELIX   79 AI7 ARG C  330  SER C  345  1                                  16    
HELIX   80 AI8 GLN C  346  ASN C  361  1                                  16    
HELIX   81 AI9 ALA C  367  MET C  378  1                                  12    
HELIX   82 AJ1 ASN C  380  ASN C  395  1                                  16    
HELIX   83 AJ2 ASP C  398  LEU C  412  1                                  15    
HELIX   84 AJ3 MET C  414  ARG C  429  1                                  16    
HELIX   85 AJ4 SER C  433  LEU C  446  1                                  14    
HELIX   86 AJ5 GLN C  448  VAL C  462  1                                  15    
HELIX   87 AJ6 MET C  468  LEU C  480  1                                  13    
HELIX   88 AJ7 GLU C  482  SER C  499  1                                  18    
HELIX   89 AJ8 SER C  510  LYS C  524  1                                  15    
HELIX   90 AJ9 LEU C  525  PHE C  539  1                                  15    
HELIX   91 AK1 GLU C  544  ARG C  557  1                                  14    
HELIX   92 AK2 GLU D   26  GLU D   46  1                                  21    
HELIX   93 AK3 PHE E   53  LEU E   89  1                                  37    
HELIX   94 AK4 GLU E   90  PHE E   96  5                                   7    
HELIX   95 AK5 PRO E   98  LEU E  103  1                                   6    
HELIX   96 AK6 GLU F    6  TYR F   19  1                                  14    
HELIX   97 AK7 ALA F   20  VAL F   35  1                                  16    
HELIX   98 AK8 SER F   37  GLY F   52  1                                  16    
HELIX   99 AK9 LYS F   53  GLY F   63  1                                  11    
HELIX  100 AL1 THR F   68  LEU F   82  1                                  15    
HELIX  101 AL2 LEU F   85  SER F   93  1                                   9    
HELIX  102 AL3 ASP F  104  GLY F  111  1                                   8    
HELIX  103 AL4 ASP F  112  THR F  128  1                                  17    
HELIX  104 AL5 ARG F  130  ASN F  145  1                                  16    
HELIX  105 AL6 TRP F  149  GLY F  159  1                                  11    
HELIX  106 AL7 ASP F  163  PHE F  168  1                                   6    
HELIX  107 AL8 LYS F  456  SER F  478  1                                  23    
HELIX  108 AL9 ASN F  480  HIS F  490  1                                  11    
HELIX  109 AM1 PRO F  492  ASN F  497  1                                   6    
HELIX  110 AM2 THR F  498  LEU F  512  1                                  15    
HELIX  111 AM3 GLU F  514  ASN F  530  1                                  17    
HELIX  112 AM4 GLY F  535  LEU F  546  1                                  12    
HELIX  113 AM5 LYS F  548  ASP F  563  1                                  16    
HELIX  114 AM6 SER F  566  LEU F  579  1                                  14    
HELIX  115 AM7 GLU F  582  ASP F  597  1                                  16    
HELIX  116 AM8 ALA F  601  LEU F  613  1                                  13    
HELIX  117 AM9 ASP F  618  ASN F  631  1                                  14    
HELIX  118 AN1 HIS F  634  GLN F  648  1                                  15    
HELIX  119 AN2 LYS F  650  ASN F  665  1                                  16    
HELIX  120 AN3 GLN F  667  LEU F  682  1                                  16    
HELIX  121 AN4 ASN F  693  ASP F  699  1                                   7    
HELIX  122 AN5 ASN F  702  ALA F  715  1                                  14    
HELIX  123 AN6 LYS F  718  GLN F  731  1                                  14    
HELIX  124 AN7 GLU F  736  GLY F  751  1                                  16    
HELIX  125 AN8 LYS G   12  GLU G   17  1                                   6    
HELIX  126 AN9 GLU G   17  ARG G   23  1                                   7    
HELIX  127 AO1 GLU H    6  ASN H   17  1                                  12    
HELIX  128 AO2 ALA H   20  HIS H   36  1                                  17    
HELIX  129 AO3 SER H   37  SER H   51  1                                  15    
HELIX  130 AO4 LYS H   53  HIS H   64  1                                  12    
HELIX  131 AO5 THR H   68  LEU H   82  1                                  15    
HELIX  132 AO6 LYS H   84  SER H   93  1                                  10    
HELIX  133 AO7 SER H  102  GLY H  111  1                                  10    
HELIX  134 AO8 SER H  113  THR H  128  1                                  16    
HELIX  135 AO9 ARG H  130  ASN H  145  1                                  16    
HELIX  136 AP1 TRP H  149  ILE H  158  1                                  10    
HELIX  137 AP2 PRO H  164  GLN H  174  1                                  11    
HELIX  138 AP3 PHE H  452  SER H  478  1                                  27    
HELIX  139 AP4 ASN H  480  SER H  489  1                                  10    
HELIX  140 AP5 THR H  498  SER H  513  1                                  16    
HELIX  141 AP6 GLU H  514  GLU H  529  1                                  16    
HELIX  142 AP7 GLY H  535  LEU H  546  1                                  12    
HELIX  143 AP8 LYS H  548  ASP H  563  1                                  16    
HELIX  144 AP9 SER H  566  GLN H  580  1                                  15    
HELIX  145 AQ1 GLU H  582  VAL H  596  1                                  15    
HELIX  146 AQ2 ALA H  601  THR H  614  1                                  14    
HELIX  147 AQ3 GLU H  616  ASN H  631  1                                  16    
HELIX  148 AQ4 HIS H  634  GLU H  649  1                                  16    
HELIX  149 AQ5 LYS H  650  ASN H  665  1                                  16    
HELIX  150 AQ6 SER H  668  LEU H  682  1                                  15    
HELIX  151 AQ7 LYS H  684  ASP H  699  1                                  16    
HELIX  152 AQ8 PRO H  703  ASN H  716  1                                  14    
HELIX  153 AQ9 LYS H  718  VAL H  733  1                                  16    
HELIX  154 AR1 GLU H  736  GLY H  751  1                                  16    
HELIX  155 AR2 GLN H  752  ASP H  767  1                                  16    
HELIX  156 AR3 LEU I   49  HIS I   53  5                                   5    
HELIX  157 AR4 SER I  123  LEU I  137  1                                  15    
HELIX  158 AR5 GLU I  159  LEU I  168  1                                  10    
HELIX  159 AR6 TYR I  190  MET I  192  5                                   3    
HELIX  160 AR7 THR I  238  PHE I  244  1                                   7    
HELIX  161 AR8 PHE I  244  ASN I  295  1                                  52    
HELIX  162 AR9 SER I  299  LEU I  309  1                                  11    
HELIX  163 AS1 GLU I  316  LEU I  325  1                                  10    
HELIX  164 AS2 THR I  326  SER I  371  1                                  46    
HELIX  165 AS3 TRP I  372  GLU I  377  1                                   6    
HELIX  166 AS4 ASP I  382  THR I  429  1                                  48    
HELIX  167 AS5 THR I  441  PHE I  451  1                                  11    
HELIX  168 AS6 ARG I  474  TYR I  478  1                                   5    
HELIX  169 AS7 ASN I  495  ASN I  503  1                                   9    
HELIX  170 AS8 SER I  521  MET I  548  1                                  28    
HELIX  171 AS9 LEU I  671  TYR I  675  1                                   5    
HELIX  172 AT1 ASP I  679  TYR I  683  5                                   5    
HELIX  173 AT2 ARG I  692  GLN I  696  5                                   5    
HELIX  174 AT3 LEU J    3  GLN J   17  1                                  15    
HELIX  175 AT4 GLN J   18  SER J   33  1                                  16    
HELIX  176 AT5 GLU J   36  THR J   50  1                                  15    
HELIX  177 AT6 GLN J   52  ARG J   63  1                                  12    
HELIX  178 AT7 LYS J   64  GLU J   70  1                                   7    
HELIX  179 AT8 ALA J   71  ALA J   83  1                                  13    
HELIX  180 AT9 GLN J   88  ASP J   94  1                                   7    
HELIX  181 AU1 GLN J  125  LEU J  143  1                                  19    
HELIX  182 AU2 ASN J  145  ASP J  160  1                                  16    
HELIX  183 AU3 PHE J  164  HIS J  173  1                                  10    
HELIX  184 AU4 THR J  177  SER J  187  1                                  11    
HELIX  185 AU5 CYS J  194  LYS J  208  1                                  15    
HELIX  186 AU6 ASP J  225  GLU J  229  5                                   5    
HELIX  187 AU7 ASN J  230  ASN J  244  1                                  15    
HELIX  188 AU8 ASP J  246  ASP J  261  1                                  16    
HELIX  189 AU9 SER J  266  ASN J  279  1                                  14    
HELIX  190 AV1 LYS J  280  TYR J  295  1                                  16    
HELIX  191 AV2 ASN J  298  GLY J  313  1                                  16    
HELIX  192 AV3 LYS J  315  GLU J  330  1                                  16    
HELIX  193 AV4 GLY J  334  SER J  348  1                                  15    
HELIX  194 AV5 GLU J  349  MET J  364  1                                  16    
HELIX  195 AV6 HIS J  368  THR J  381  1                                  14    
HELIX  196 AV7 ASN J  383  ILE J  397  1                                  15    
HELIX  197 AV8 ASP J  401  GLY J  416  1                                  16    
HELIX  198 AV9 LYS J  419  LYS J  433  1                                  15    
HELIX  199 AW1 TRP J  444  LEU J  458  1                                  15    
HELIX  200 AW2 LYS J  460  ILE J  475  1                                  16    
HELIX  201 AW3 ALA J  479  MET J  492  1                                  14    
HELIX  202 AW4 ASN J  494  ARG J  509  1                                  16    
HELIX  203 AW5 THR J  513  ASP J  529  1                                  17    
HELIX  204 AW6 LEU K    3  GLN K   16  1                                  14    
HELIX  205 AW7 GLN K   18  ARG K   34  1                                  17    
HELIX  206 AW8 GLU K   36  THR K   50  1                                  15    
HELIX  207 AW9 GLN K   52  SER K   62  1                                  11    
HELIX  208 AX1 LYS K   64  TYR K   69  1                                   6    
HELIX  209 AX2 TYR K   69  ALA K   83  1                                  15    
HELIX  210 AX3 ILE K  128  LEU K  143  1                                  16    
HELIX  211 AX4 ASN K  145  ASP K  160  1                                  16    
HELIX  212 AX5 PHE K  164  THR K  171  1                                   8    
HELIX  213 AX6 MET K  175  ALA K  178  5                                   4    
HELIX  214 AX7 GLN K  179  LEU K  188  1                                  10    
HELIX  215 AX8 CYS K  194  LYS K  210  1                                  17    
HELIX  216 AX9 THR K  218  ASP K  225  1                                   8    
HELIX  217 AY1 ASN K  230  ASN K  244  1                                  15    
HELIX  218 AY2 ASP K  246  ASP K  261  1                                  16    
HELIX  219 AY3 CYS K  267  ASN K  279  1                                  13    
HELIX  220 AY4 LYS K  280  TYR K  295  1                                  16    
HELIX  221 AY5 ASN K  298  GLY K  313  1                                  16    
HELIX  222 AY6 LYS K  315  GLU K  330  1                                  16    
HELIX  223 AY7 TYR K  333  GLU K  347  1                                  15    
HELIX  224 AY8 GLU K  349  MET K  364  1                                  16    
HELIX  225 AY9 CYS K  367  THR K  381  1                                  15    
HELIX  226 AZ1 ASN K  383  ALA K  398  1                                  16    
HELIX  227 AZ2 ASP K  401  GLY K  416  1                                  16    
HELIX  228 AZ3 GLU K  417  GLY K  436  1                                  20    
HELIX  229 AZ4 THR K  440  LEU K  458  1                                  19    
HELIX  230 AZ5 LYS K  460  ILE K  475  1                                  16    
HELIX  231 AZ6 ASN K  478  GLY K  493  1                                  16    
HELIX  232 AZ7 ASN K  494  ARG K  509  1                                  16    
HELIX  233 AZ8 ASP K  512  ILE K  527  1                                  16    
HELIX  234 AZ9 ASP L   12  GLY L   20  1                                   9    
HELIX  235 BA1 GLY L   41  ARG L   46  1                                   6    
HELIX  236 BA2 THR L  174  SER L  182  5                                   9    
HELIX  237 BA3 ASP M    8  ASP M   16  1                                   9    
HELIX  238 BA4 SER M   49  MET M   55  1                                   7    
HELIX  239 BA5 PRO N   16  THR N   29  1                                  14    
HELIX  240 BA6 LYS N   51  HIS N   65  1                                  15    
HELIX  241 BA7 SER N   69  GLU N   99  1                                  31    
HELIX  242 BA8 GLU N  104  ARG N  121  1                                  18    
HELIX  243 BA9 ASP N  123  ARG N  137  1                                  15    
HELIX  244 BB1 GLN N  147  PHE N  162  1                                  16    
HELIX  245 BB2 ARG N  167  GLY N  191  1                                  25    
HELIX  246 BB3 CYS N  233  SER N  251  1                                  19    
HELIX  247 BB4 LEU N  253  ARG N  278  1                                  26    
HELIX  248 BB5 HIS N  290  PHE N  304  1                                  15    
HELIX  249 BB6 LEU N  321  GLU N  343  1                                  23    
HELIX  250 BB7 GLU N  343  ASP N  350  1                                   8    
HELIX  251 BB8 SER N  354  THR N  368  1                                  15    
HELIX  252 BB9 ARG N  371  LEU N  386  1                                  16    
HELIX  253 BC1 ASN N  392  LEU N  407  1                                  16    
HELIX  254 BC2 ILE N  416  ARG N  431  1                                  16    
HELIX  255 BC3 VAL N  435  THR N  443  1                                   9    
HELIX  256 BC4 ASP N  500  TYR N  509  1                                  10    
HELIX  257 BC5 SER N  511  LEU N  527  1                                  17    
HELIX  258 BC6 SER N  534  PHE N  549  1                                  16    
HELIX  259 BC7 GLU N  551  LYS N  580  1                                  30    
HELIX  260 BC8 PRO N  612  LYS N  630  1                                  19    
HELIX  261 BC9 LYS N  638  GLY N  642  5                                   5    
HELIX  262 BD1 THR N  660  ASP N  672  1                                  13    
HELIX  263 BD2 THR N  677  LYS N  686  1                                  10    
HELIX  264 BD3 PRO N  688  GLY N  703  1                                  16    
HELIX  265 BD4 GLU N  748  GLU N  766  1                                  19    
HELIX  266 BD5 SER N  769  VAL N  781  1                                  13    
HELIX  267 BD6 ASP N  791  VAL N  803  1                                  13    
HELIX  268 BD7 THR O   31  SER O   45  1                                  15    
HELIX  269 BD8 SER O   53  GLN O   62  1                                  10    
HELIX  270 BD9 LEU O   63  GLY O   70  1                                   8    
HELIX  271 BE1 THR O   74  CYS O   86  1                                  13    
HELIX  272 BE2 PRO O   87  GLY O  103  1                                  17    
HELIX  273 BE3 LEU O  105  ASP O  117  1                                  13    
HELIX  274 BE4 SER O  130  LEU O  146  1                                  17    
HELIX  275 BE5 SER O  147  LYS O  167  1                                  21    
HELIX  276 BE6 SER O  208  ASP O  226  1                                  19    
HELIX  277 BE7 THR O  232  ASN O  247  1                                  16    
HELIX  278 BE8 ALA O  251  GLN O  265  1                                  15    
HELIX  279 BE9 VAL O  267  ARG O  280  1                                  14    
HELIX  280 BF1 GLY O  297  GLY O  315  1                                  19    
HELIX  281 BF2 HIS O  316  ASN O  335  1                                  20    
HELIX  282 BF3 HIS O  337  GLY O  351  1                                  15    
HELIX  283 BF4 LEU O  360  HIS O  370  1                                  11    
HELIX  284 BF5 LEU O  373  ALA O  391  1                                  19    
HELIX  285 BF6 LEU O  402  HIS O  412  1                                  11    
HELIX  286 BF7 SER O  415  GLY O  433  1                                  19    
HELIX  287 BF8 ARG O  434  MET O  448  1                                  15    
HELIX  288 BF9 THR O  463  GLY O  481  1                                  19    
HELIX  289 BG1 CYS O  482  PHE O  497  1                                  16    
HELIX  290 BG2 ALA O  504  GLY O  523  1                                  20    
HELIX  291 BG3 LYS O  524  ASN O  539  1                                  16    
HELIX  292 BG4 ILE O  541  GLN O  554  1                                  14    
HELIX  293 BG5 GLN O  556  LYS O  575  1                                  20    
HELIX  294 BG6 ASN O  576  ARG O  593  1                                  18    
HELIX  295 BG7 SER O  594  SER O  595  5                                   2    
HELIX  296 BG8 SER O  596  THR O  598  5                                   3    
HELIX  297 BG9 ILE O  599  ARG O  615  1                                  17    
HELIX  298 BH1 LEU O  616  LEU O  634  1                                  19    
HELIX  299 BH2 ILE O  636  ILE O  648  1                                  13    
HELIX  300 BH3 ILE O  648  ALA O  653  1                                   6    
HELIX  301 BH4 ILE O  657  TYR O  678  1                                  22    
HELIX  302 BH5 LYS O  682  ASP O  705  1                                  24    
HELIX  303 BH6 ILE O  710  GLY O  725  1                                  16    
HELIX  304 BH7 LYS O  726  GLU O  743  1                                  18    
HELIX  305 BH8 ASP P   28  ARG P   46  1                                  19    
HELIX  306 BH9 LEU P   49  LEU P   62  1                                  14    
HELIX  307 BI1 THR P   77  ASP P   95  1                                  19    
HELIX  308 BI2 GLU P   98  LEU P  106  1                                   9    
HELIX  309 BI3 LYS P  112  THR P  134  1                                  23    
HELIX  310 BI4 ASN P  148  ALA P  164  1                                  17    
HELIX  311 BI5 GLY P  169  LEU P  182  1                                  14    
HELIX  312 BI6 VAL P  185  LEU P  199  1                                  15    
HELIX  313 BI7 HIS P  202  ILE P  213  1                                  12    
HELIX  314 BI8 ASP P  215  LEU P  222  1                                   8    
HELIX  315 BI9 THR P  227  LEU P  241  1                                  15    
HELIX  316 BJ1 LEU P  243  GLY P  258  1                                  16    
HELIX  317 BJ2 SER P  262  ILE P  276  1                                  15    
HELIX  318 BJ3 ASP P  278  ASP P  293  1                                  16    
HELIX  319 BJ4 ASN P  299  ARG P  310  1                                  12    
HELIX  320 BJ5 MET P  312  ASP P  327  1                                  16    
HELIX  321 BJ6 ARG P  330  SER P  345  1                                  16    
HELIX  322 BJ7 GLN P  346  ASN P  361  1                                  16    
HELIX  323 BJ8 TYR P  364  MET P  378  1                                  15    
HELIX  324 BJ9 ASN P  380  ASN P  395  1                                  16    
HELIX  325 BK1 TYR P  399  ILE P  411  1                                  13    
HELIX  326 BK2 PRO P  415  ARG P  429  1                                  15    
HELIX  327 BK3 ASP P  432  LEU P  446  1                                  15    
HELIX  328 BK4 GLN P  448  GLY P  463  1                                  16    
HELIX  329 BK5 LYS P  467  LEU P  480  1                                  14    
HELIX  330 BK6 SER P  483  TYR P  498  1                                  16    
HELIX  331 BK7 ALA P  512  LYS P  524  1                                  13    
HELIX  332 BK8 LEU P  525  CYS P  537  1                                  13    
HELIX  333 BK9 LYS W   12  ASP W   14  5                                   3    
HELIX  334 BL1 ASP W   15  ARG W   23  1                                   9    
HELIX  335 BL2 VAL X   37  ALA X   47  1                                  11    
HELIX  336 BL3 HIS X   50  ASN X   66  1                                  17    
HELIX  337 BL4 SER X   72  ASP X   90  1                                  19    
HELIX  338 BL5 TYR X   93  ALA X  109  1                                  17    
HELIX  339 BL6 SER X  134  LEU X  149  1                                  16    
HELIX  340 BL7 GLN X  151  ILE X  162  1                                  12    
HELIX  341 BL8 THR X  168  GLY X  183  1                                  16    
HELIX  342 BL9 GLN X  184  CYS X  199  1                                  16    
HELIX  343 BM1 ALA X  202  LEU X  212  1                                  11    
HELIX  344 BM2 LYS X  215  THR X  229  1                                  15    
HELIX  345 BM3 ASP X  234  GLY X  249  1                                  16    
HELIX  346 BM4 ASP X  250  LYS X  263  1                                  14    
HELIX  347 BM5 ASN X  270  ALA X  284  1                                  15    
HELIX  348 BM6 ASN X  287  ASP X  301  1                                  15    
HELIX  349 BM7 LEU X  304  GLU X  318  1                                  15    
HELIX  350 BM8 LEU X  321  ILE X  334  1                                  14    
HELIX  351 BM9 HIS X  338  SER X  352  1                                  15    
HELIX  352 BN1 ARG X  354  ASN X  369  1                                  16    
HELIX  353 BN2 SER X  372  GLY X  387  1                                  16    
HELIX  354 BN3 ARG X  388  ALA X  403  1                                  16    
HELIX  355 BN4 ARG X  406  SER X  420  1                                  15    
HELIX  356 BN5 SER X  422  GLY X  438  1                                  17    
HELIX  357 BN6 ALA X  441  ASP X  454  1                                  14    
HELIX  358 BN7 GLN X  458  ARG X  472  1                                  15    
HELIX  359 BN8 TYR X  475  GLN X  490  1                                  16    
HELIX  360 BN9 TYR X  492  LEU X  503  1                                  12    
HELIX  361 BO1 ASP X  508  VAL X  520  1                                  13    
HELIX  362 BO2 TYR X  525  ASP X  539  1                                  15    
HELIX  363 BO3 VAL Y   37  ALA Y   47  1                                  11    
HELIX  364 BO4 LEU Y   49  ASN Y   67  1                                  19    
HELIX  365 BO5 SER Y   72  ASP Y   90  1                                  19    
HELIX  366 BO6 TYR Y   93  LEU Y  110  1                                  18    
HELIX  367 BO7 SER Y  134  LEU Y  149  1                                  16    
HELIX  368 BO8 GLN Y  151  GLY Y  161  1                                  11    
HELIX  369 BO9 THR Y  168  GLY Y  183  1                                  16    
HELIX  370 BP1 GLN Y  184  CYS Y  199  1                                  16    
HELIX  371 BP2 ALA Y  202  SER Y  213  1                                  12    
HELIX  372 BP3 LYS Y  215  THR Y  229  1                                  15    
HELIX  373 BP4 TRP Y  235  THR Y  248  1                                  14    
HELIX  374 BP5 ASP Y  250  LYS Y  264  1                                  15    
HELIX  375 BP6 ASN Y  270  ALA Y  284  1                                  15    
HELIX  376 BP7 ASP Y  286  ASP Y  301  1                                  16    
HELIX  377 BP8 GLY Y  307  GLU Y  318  1                                  12    
HELIX  378 BP9 ARG Y  320  SER Y  335  1                                  16    
HELIX  379 BQ1 HIS Y  338  SER Y  352  1                                  15    
HELIX  380 BQ2 ARG Y  354  ASN Y  369  1                                  16    
HELIX  381 BQ3 SER Y  372  GLY Y  387  1                                  16    
HELIX  382 BQ4 ARG Y  388  ALA Y  403  1                                  16    
HELIX  383 BQ5 ARG Y  406  SER Y  420  1                                  15    
HELIX  384 BQ6 SER Y  422  GLY Y  438  1                                  17    
HELIX  385 BQ7 ALA Y  441  GLU Y  453  1                                  13    
HELIX  386 BQ8 GLN Y  458  ARG Y  472  1                                  15    
HELIX  387 BQ9 TYR Y  475  GLN Y  490  1                                  16    
HELIX  388 BR1 TYR Y  492  ALA Y  504  1                                  13    
HELIX  389 BR2 CYS Y  509  ASN Y  523  1                                  15    
HELIX  390 BR3 GLU Y  524  ASP Y  539  1                                  16    
HELIX  391 BR4 ASP Y  542  LYS Y  551  1                                  10    
SHEET    1 AA1 4 ASP A  16  PHE A  20  0                                        
SHEET    2 AA1 4 MET A 604  THR A 608 -1  O  MET A 604   N  PHE A  20           
SHEET    3 AA1 4 ARG A 594  LEU A 599 -1  N  VAL A 595   O  ILE A 607           
SHEET    4 AA1 4 ILE A 584  VAL A 591 -1  N  VAL A 591   O  ARG A 594           
SHEET    1 AA2 4 SER A  73  LYS A  78  0                                        
SHEET    2 AA2 4 ASP A  90  VAL A  95 -1  O  VAL A  95   N  SER A  73           
SHEET    3 AA2 4 MET A  99  SER A 103 -1  O  SER A 103   N  GLU A  92           
SHEET    4 AA2 4 VAL A 113  THR A 118 -1  O  PHE A 117   N  VAL A 100           
SHEET    1 AA3 4 LEU A 127  TRP A 128  0                                        
SHEET    2 AA3 4 CYS A 150  LEU A 154 -1  O  CYS A 152   N  LEU A 127           
SHEET    3 AA3 4 ILE A 159  SER A 163 -1  O  ASN A 160   N  ILE A 153           
SHEET    4 AA3 4 ASP A 168  ALA A 171 -1  O  ALA A 171   N  ILE A 159           
SHEET    1 AA4 4 VAL A 180  THR A 183  0                                        
SHEET    2 AA4 4 GLY A 186  PHE A 189 -1  O  LEU A 188   N  TRP A 181           
SHEET    3 AA4 4 PHE A 211  MET A 213 -1  O  PHE A 211   N  PHE A 189           
SHEET    4 AA4 4 THR A 221  PRO A 222 -1  O  THR A 221   N  SER A 212           
SHEET    1 AA5 2 VAL A 224  CYS A 225  0                                        
SHEET    2 AA5 2 GLN A 237  TYR A 238 -1  O  GLN A 237   N  CYS A 225           
SHEET    1 AA6 2 MET A 244  LEU A 249  0                                        
SHEET    2 AA6 2 VAL A 256  ASP A 260 -1  O  TYR A 259   N  LYS A 245           
SHEET    1 AA7 2 VAL A 268  ARG A 272  0                                        
SHEET    2 AA7 2 CYS A 408  TRP A 413 -1  O  TRP A 413   N  VAL A 268           
SHEET    1 AA8 4 VAL A 430  ILE A 432  0                                        
SHEET    2 AA8 4 LYS A 440  LEU A 445 -1  O  CYS A 443   N  PHE A 431           
SHEET    3 AA8 4 LEU A 452  GLU A 459 -1  O  ARG A 453   N  PHE A 444           
SHEET    4 AA8 4 LEU A 466  ILE A 474 -1  O  THR A 472   N  CYS A 454           
SHEET    1 AA9 3 ASP A 478  VAL A 482  0                                        
SHEET    2 AA9 3 THR A 487  GLU A 492 -1  O  LEU A 491   N  ASP A 478           
SHEET    3 AA9 3 ASN A 496  TYR A 500 -1  O  ASN A 496   N  GLU A 492           
SHEET    1 AB1 3 VAL A1047  ARG A1048  0                                        
SHEET    2 AB1 3 THR A1108  ALA A1111  1  O  THR A1108   N  VAL A1047           
SHEET    3 AB1 3 THR A1116  ASP A1119 -1  O  VAL A1118   N  GLY A1109           
SHEET    1 AB2 6 ILE A1352  LYS A1353  0                                        
SHEET    2 AB2 6 TRP L  31  LEU L  33 -1  O  TRP L  31   N  LYS A1353           
SHEET    3 AB2 6 HIS L  62  GLN L  67 -1  O  ASN L  65   N  SER L  32           
SHEET    4 AB2 6 MET L 136  VAL L 141 -1  O  ILE L 137   N  ILE L  66           
SHEET    5 AB2 6 ILE L  94  GLY L  99 -1  N  SER L  95   O  ALA L 140           
SHEET    6 AB2 6 LEU L 105  GLN L 110 -1  O  ARG L 109   N  VAL L  96           
SHEET    1 AB3 2 VAL A1622  ASP A1623  0                                        
SHEET    2 AB3 2 THR A1628  PRO A1629 -1  O  THR A1628   N  ASP A1623           
SHEET    1 AB4 3 GLU A1650  MET A1652  0                                        
SHEET    2 AB4 3 LEU A1633  TYR A1638 -1  N  LEU A1634   O  LEU A1651           
SHEET    3 AB4 3 LEU A1663  VAL A1668 -1  O  LYS A1667   N  GLU A1635           
SHEET    1 AB5 4 GLY N 590  ALA N 593  0                                        
SHEET    2 AB5 4 VAL B   3  GLY B  10  1  N  GLY B  10   O  TYR N 592           
SHEET    3 AB5 4 LEU N 643  VAL N 648 -1  O  ASP N 647   N  LYS B   4           
SHEET    4 AB5 4 LEU N 655  SER N 656 -1  O  LEU N 655   N  VAL N 648           
SHEET    1 AB6 2 LEU B  46  TRP B  48  0                                        
SHEET    2 AB6 2 CYS B  54  HIS B  56 -1  O  PHE B  55   N  VAL B  47           
SHEET    1 AB7 3 ILE I  23  PHE I  25  0                                        
SHEET    2 AB7 3 ILE I  35  ASN I  39 -1  O  ALA I  38   N  PHE I  25           
SHEET    3 AB7 3 VAL I  44  HIS I  47 -1  O  HIS I  47   N  ILE I  35           
SHEET    1 AB8 4 VAL I  68  TRP I  73  0                                        
SHEET    2 AB8 4 LEU I  79  LEU I  84 -1  O  ALA I  81   N  ALA I  72           
SHEET    3 AB8 4 LYS I  89  ASP I  94 -1  O  CYS I  93   N  LEU I  80           
SHEET    4 AB8 4 HIS I 102  SER I 105 -1  O  PHE I 104   N  ILE I  90           
SHEET    1 AB9 3 LEU I 176  LEU I 178  0                                        
SHEET    2 AB9 3 GLU I 186  ALA I 189 -1  O  GLU I 186   N  LEU I 178           
SHEET    3 AB9 3 PHE I 193  ARG I 197 -1  O  ALA I 196   N  LEU I 187           
SHEET    1 AC1 4 THR I 204  LEU I 210  0                                        
SHEET    2 AC1 4 SER I 216  GLU I 222 -1  O  GLU I 222   N  THR I 204           
SHEET    3 AC1 4 SER I 229  GLU I 237 -1  O  SER I 232   N  THR I 221           
SHEET    4 AC1 4 ALA I 551  ASP I 559 -1  O  ASP I 559   N  SER I 229           
SHEET    1 AC2 5 PHE I 574  ASN I 578  0                                        
SHEET    2 AC2 5 LEU I 583  LEU I 591 -1  O  TYR I 585   N  TRP I 576           
SHEET    3 AC2 5 TYR I 596  HIS I 604 -1  O  LYS I 597   N  ILE I 590           
SHEET    4 AC2 5 LEU I 615  PHE I 623 -1  O  ILE I 616   N  ILE I 600           
SHEET    5 AC2 5 THR I 702  PHE I 707  1  O  MET I 705   N  GLY I 621           
SHEET    1 AC3 4 TYR I 636  PHE I 643  0                                        
SHEET    2 AC3 4 THR I 648  ASP I 655 -1  O  VAL I 652   N  ASP I 640           
SHEET    3 AC3 4 ARG I 664  PRO I 670 -1  O  LEU I 665   N  LEU I 653           
SHEET    4 AC3 4 TRP I 711  LEU I 714 -1  O  LEU I 714   N  ARG I 664           
SHEET    1 AC4 3 ALA I 719  GLY I 724  0                                        
SHEET    2 AC4 3 VAL I 730  SER I 735 -1  O  LEU I 734   N  TYR I 721           
SHEET    3 AC4 3 VAL I 741  GLU I 745 -1  O  PHE I 744   N  SER I 731           
SHEET    1 AC5 4 VAL L  22  GLU L  24  0                                        
SHEET    2 AC5 4 GLN L 155  PRO L 161 -1  O  THR L 160   N  ARG L  23           
SHEET    3 AC5 4 THR L  76  TYR L  80 -1  N  TYR L  80   O  GLN L 155           
SHEET    4 AC5 4 TRP L 119  PRO L 123 -1  O  VAL L 122   N  LEU L  77           
SHEET    1 AC6 2 THR L  73  VAL L  74  0                                        
SHEET    2 AC6 2 THR L 132  ARG L 133 -1  O  THR L 132   N  VAL L  74           
SSBOND   1 CYS A  129    CYS A  152                          1555   1555  2.04  
LINK         SG  CYS B  23                ZN    ZN B 101     1555   1555  2.59  
LINK         O   MET B  28                ZN    ZN B 101     1555   1555  2.36  
LINK         N   CYS B  37                ZN    ZN B 103     1555   1555  2.61  
LINK         O   CYS B  37                ZN    ZN B 103     1555   1555  1.95  
LINK         SG  CYS B  51                ZN    ZN B 102     1555   1555  2.47  
LINK         ND1 HIS B  53                ZN    ZN B 102     1555   1555  2.70  
LINK         ND1 HIS B  56                ZN    ZN B 101     1555   1555  2.19  
LINK         SG  CYS B  76                ZN    ZN B 102     1555   1555  2.39  
CISPEP   1 SER A  134    GLN A  135          0       -12.40                     
CISPEP   2 SER A  192    ALA A  193          0        -5.95                     
CISPEP   3 THR A  414    GLU A  415          0        -9.43                     
CISPEP   4 ARG A  815    THR A  816          0         1.60                     
CISPEP   5 MET A  831    HIS A  832          0         4.29                     
CISPEP   6 PRO A 1112    PRO A 1113          0         4.34                     
CISPEP   7 GLY A 1670    PRO A 1671          0        -8.96                     
CISPEP   8 ARG A 1731    ALA A 1732          0        20.09                     
CISPEP   9 HIS A 1833    PRO A 1834          0        -5.72                     
CISPEP  10 GLN B   68    VAL B   69          0         6.80                     
CISPEP  11 VAL C   96    LYS C   97          0        12.19                     
CISPEP  12 PRO C  140    LEU C  141          0         6.57                     
CISPEP  13 ASN C  361    PRO C  362          0        -1.43                     
CISPEP  14 ARG G   23    LYS G   24          0         0.07                     
CISPEP  15 LYS G   24    ASP G   25          0        -5.27                     
CISPEP  16 ASN H  145    PRO H  146          0       -14.65                     
CISPEP  17 ALA I  313    SER I  314          0        -0.60                     
CISPEP  18 GLU I  430    ASP I  431          0        14.99                     
CISPEP  19 PHE I  572    PRO I  573          0        -2.55                     
CISPEP  20 GLN L   60    PRO L   61          0         1.98                     
CISPEP  21 THR L  125    ASP L  126          0         8.12                     
CISPEP  22 PHE L  170    PRO L  171          0        -8.04                     
CISPEP  23 HIS N   65    GLY N   66          0        -0.35                     
CISPEP  24 ALA N  102    ASP N  103          0        -0.20                     
CISPEP  25 ASP N  103    GLU N  104          0        -7.87                     
CISPEP  26 ARG N  121    LEU N  122          0        24.09                     
CISPEP  27 SER N  164    THR N  165          0        26.82                     
CISPEP  28 PHE N  351    PRO N  352          0        -3.35                     
CISPEP  29 TYR N  509    GLY N  510          0         0.22                     
CISPEP  30 SER N  532    PHE N  533          0       -11.53                     
CISPEP  31 GLY N  550    GLU N  551          0         2.15                     
CISPEP  32 PRO N  709    PRO N  710          0         3.39                     
CISPEP  33 GLU O  123    PRO O  124          0        -0.98                     
CISPEP  34 VAL P   96    LYS P   97          0        18.76                     
CISPEP  35 ASN P  361    PRO P  362          0       -13.41                     
CISPEP  36 LEU T    7    ALA T    8          0        -9.97                     
CISPEP  37 ALA T   11    ALA T   12          0        17.10                     
CISPEP  38 ASP W   25    LEU W   26          0        -1.18                     
CISPEP  39 CYS Y  199    PRO Y  200          0        -6.98                     
SITE     1 AC1  3 CYS B  23  MET B  28  HIS B  56                               
SITE     1 AC2  3 CYS B  51  HIS B  53  CYS B  76                               
SITE     1 AC3  4 CYS B  33  CYS B  34  CYS B  37  CYS B  44                    
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1           1          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      1.000000  0.000000  0.000000        0.00000                         
SCALE2      0.000000  1.000000  0.000000        0.00000                         
SCALE3      0.000000  0.000000  1.000000        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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