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Database: PDB
Entry: 6U9E
LinkDB: 6U9E
Original site: 6U9E 
HEADER    TRANSPORT PROTEIN                       08-SEP-19   6U9E              
TITLE     STRUCTURE OF PDPA-VGRG COMPLEX, LIDLESS                               
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: PDPA;                                                      
COMPND   3 CHAIN: A, C, E;                                                      
COMPND   4 ENGINEERED: YES;                                                     
COMPND   5 MOL_ID: 2;                                                           
COMPND   6 MOLECULE: VGRG;                                                      
COMPND   7 CHAIN: B, D, F;                                                      
COMPND   8 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: FRANCISELLA NOVICIDA;                           
SOURCE   3 ORGANISM_TAXID: 264;                                                 
SOURCE   4 GENE: PDPA;                                                          
SOURCE   5 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE   6 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE   7 MOL_ID: 2;                                                           
SOURCE   8 ORGANISM_SCIENTIFIC: FRANCISELLA NOVICIDA;                           
SOURCE   9 ORGANISM_TAXID: 264;                                                 
SOURCE  10 GENE: B4919_03525;                                                   
SOURCE  11 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  12 EXPRESSION_SYSTEM_TAXID: 562                                         
KEYWDS    T6SS CENTRAL SPIKE, COMPLEX, TRANSPORT PROTEIN                        
EXPDTA    ELECTRON MICROSCOPY                                                   
AUTHOR    X.YANG,D.L.CLEMENS,B.-Y.LEE,Y.CUI,Z.H.ZHOU,M.A.HORWITZ                
REVDAT   1   23-OCT-19 6U9E    0                                                
JRNL        AUTH   X.YANG,D.L.CLEMENS,B.-Y.LEE,Y.CUI,Z.H.ZHOU,M.A.HORWITZ       
JRNL        TITL   STRUCTURE OF PDPA-VGRG COMPLEX, LIDLESS                      
JRNL        REF    TO BE PUBLISHED                                              
JRNL        REFN                                                                
REMARK   2                                                                      
REMARK   2 RESOLUTION.    4.21 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   SOFTWARE PACKAGES      : NULL                                      
REMARK   3   RECONSTRUCTION SCHEMA  : NULL                                      
REMARK   3                                                                      
REMARK   3 EM MAP-MODEL FITTING AND REFINEMENT                                  
REMARK   3   PDB ENTRY                    : NULL                                
REMARK   3   REFINEMENT SPACE             : REAL                                
REMARK   3   REFINEMENT PROTOCOL          : AB INITIO MODEL                     
REMARK   3   REFINEMENT TARGET            : NULL                                
REMARK   3   OVERALL ANISOTROPIC B VALUE  : NULL                                
REMARK   3                                                                      
REMARK   3 FITTING PROCEDURE : NULL                                             
REMARK   3                                                                      
REMARK   3 EM IMAGE RECONSTRUCTION STATISTICS                                   
REMARK   3   NOMINAL PIXEL SIZE (ANGSTROMS)    : NULL                           
REMARK   3   ACTUAL PIXEL SIZE  (ANGSTROMS)    : NULL                           
REMARK   3   EFFECTIVE RESOLUTION (ANGSTROMS)  : 4.210                          
REMARK   3   NUMBER OF PARTICLES               : 16889                          
REMARK   3   CTF CORRECTION METHOD             : PHASE FLIPPING ONLY            
REMARK   3                                                                      
REMARK   3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL                    
REMARK   3                                                                      
REMARK   3 OTHER DETAILS: NULL                                                  
REMARK   4                                                                      
REMARK   4 6U9E COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 09-SEP-19.                  
REMARK 100 THE DEPOSITION ID IS D_1000244231.                                   
REMARK 245                                                                      
REMARK 245 EXPERIMENTAL DETAILS                                                 
REMARK 245   RECONSTRUCTION METHOD          : SINGLE PARTICLE                   
REMARK 245   SPECIMEN TYPE                  : NULL                              
REMARK 245                                                                      
REMARK 245 ELECTRON MICROSCOPE SAMPLE                                           
REMARK 245   SAMPLE TYPE                    : PARTICLE                          
REMARK 245   PARTICLE TYPE                  : POINT                             
REMARK 245   NAME OF SAMPLE                 : PDPA-VGRG COMPLEX                 
REMARK 245   SAMPLE CONCENTRATION (MG ML-1) : NULL                              
REMARK 245   SAMPLE SUPPORT DETAILS         : UNSPECIFIED                       
REMARK 245   SAMPLE VITRIFICATION DETAILS   : NULL                              
REMARK 245   SAMPLE BUFFER                  : NULL                              
REMARK 245   PH                             : 7.50                              
REMARK 245   SAMPLE DETAILS                 : NULL                              
REMARK 245                                                                      
REMARK 245 DATA ACQUISITION                                                     
REMARK 245   DATE OF EXPERIMENT                : NULL                           
REMARK 245   NUMBER OF MICROGRAPHS-IMAGES      : NULL                           
REMARK 245   TEMPERATURE (KELVIN)              : NULL                           
REMARK 245   MICROSCOPE MODEL                  : FEI TITAN KRIOS                
REMARK 245   DETECTOR TYPE                     : GATAN K2 SUMMIT (4K X 4K)      
REMARK 245   MINIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MAXIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MINIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   MAXIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   NOMINAL CS                        : NULL                           
REMARK 245   IMAGING MODE                      : BRIGHT FIELD                   
REMARK 245   ELECTRON DOSE (ELECTRONS NM**-2)  : 47.00                          
REMARK 245   ILLUMINATION MODE                 : FLOOD BEAM                     
REMARK 245   NOMINAL MAGNIFICATION             : NULL                           
REMARK 245   CALIBRATED MAGNIFICATION          : NULL                           
REMARK 245   SOURCE                            : FIELD EMISSION GUN             
REMARK 245   ACCELERATION VOLTAGE (KV)         : 300                            
REMARK 245   IMAGING DETAILS                   : NULL                           
REMARK 247                                                                      
REMARK 247 ELECTRON MICROSCOPY                                                  
REMARK 247  THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON          
REMARK 247  MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE              
REMARK 247  THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES           
REMARK 247  ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION         
REMARK 247  OF THE STRUCTURE FACTORS.                                           
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: HEXAMERIC                         
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, C, E, B, D, F                      
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     MET A     1                                                      
REMARK 465     ILE A     2                                                      
REMARK 465     ALA A     3                                                      
REMARK 465     VAL A     4                                                      
REMARK 465     LYS A     5                                                      
REMARK 465     ASP A     6                                                      
REMARK 465     ILE A     7                                                      
REMARK 465     THR A     8                                                      
REMARK 465     ASP A     9                                                      
REMARK 465     LEU A    10                                                      
REMARK 465     ASN A    11                                                      
REMARK 465     ILE A    12                                                      
REMARK 465     GLN A    13                                                      
REMARK 465     ASP A    14                                                      
REMARK 465     ILE A    15                                                      
REMARK 465     ILE A    16                                                      
REMARK 465     SER A    17                                                      
REMARK 465     GLN A    18                                                      
REMARK 465     LEU A    19                                                      
REMARK 465     THR A    20                                                      
REMARK 465     SER A    21                                                      
REMARK 465     GLU A    22                                                      
REMARK 465     VAL A    23                                                      
REMARK 465     ILE A    24                                                      
REMARK 465     ASN A    25                                                      
REMARK 465     GLY A    26                                                      
REMARK 465     ASP A    27                                                      
REMARK 465     THR A    28                                                      
REMARK 465     THR A    29                                                      
REMARK 465     PRO A    30                                                      
REMARK 465     SER A    31                                                      
REMARK 465     SER A    32                                                      
REMARK 465     ALA A    33                                                      
REMARK 465     LYS A    34                                                      
REMARK 465     PHE A    35                                                      
REMARK 465     ALA A    36                                                      
REMARK 465     CYS A    37                                                      
REMARK 465     GLU A    38                                                      
REMARK 465     ILE A    39                                                      
REMARK 465     ASN A    40                                                      
REMARK 465     SER A    41                                                      
REMARK 465     TYR A    42                                                      
REMARK 465     ILE A    43                                                      
REMARK 465     ILE A    44                                                      
REMARK 465     ASN A    45                                                      
REMARK 465     TYR A    46                                                      
REMARK 465     ASN A    47                                                      
REMARK 465     LEU A    48                                                      
REMARK 465     SER A    49                                                      
REMARK 465     ASN A    50                                                      
REMARK 465     ILE A    51                                                      
REMARK 465     ASN A    52                                                      
REMARK 465     LEU A    53                                                      
REMARK 465     ILE A    54                                                      
REMARK 465     ASN A    55                                                      
REMARK 465     THR A    56                                                      
REMARK 465     GLN A    57                                                      
REMARK 465     LEU A    58                                                      
REMARK 465     LYS A    59                                                      
REMARK 465     ASN A    60                                                      
REMARK 465     THR A    61                                                      
REMARK 465     LYS A    62                                                      
REMARK 465     ILE A    63                                                      
REMARK 465     LEU A    64                                                      
REMARK 465     TYR A    65                                                      
REMARK 465     ARG A    66                                                      
REMARK 465     LYS A    67                                                      
REMARK 465     GLY A    68                                                      
REMARK 465     LEU A    69                                                      
REMARK 465     ILE A    70                                                      
REMARK 465     SER A    71                                                      
REMARK 465     LYS A    72                                                      
REMARK 465     LEU A    73                                                      
REMARK 465     ASP A    74                                                      
REMARK 465     TYR A    75                                                      
REMARK 465     GLU A    76                                                      
REMARK 465     LYS A    77                                                      
REMARK 465     TYR A    78                                                      
REMARK 465     LYS A    79                                                      
REMARK 465     ARG A    80                                                      
REMARK 465     TYR A    81                                                      
REMARK 465     CYS A    82                                                      
REMARK 465     ILE A    83                                                      
REMARK 465     ILE A    84                                                      
REMARK 465     SER A    85                                                      
REMARK 465     ARG A    86                                                      
REMARK 465     PHE A    87                                                      
REMARK 465     LYS A    88                                                      
REMARK 465     ASN A    89                                                      
REMARK 465     ASN A    90                                                      
REMARK 465     ILE A    91                                                      
REMARK 465     ASP A    92                                                      
REMARK 465     GLU A    93                                                      
REMARK 465     PHE A    94                                                      
REMARK 465     ILE A    95                                                      
REMARK 465     LEU A    96                                                      
REMARK 465     TYR A    97                                                      
REMARK 465     PHE A    98                                                      
REMARK 465     SER A    99                                                      
REMARK 465     THR A   100                                                      
REMARK 465     ASN A   101                                                      
REMARK 465     TYR A   102                                                      
REMARK 465     LYS A   103                                                      
REMARK 465     ASP A   104                                                      
REMARK 465     SER A   105                                                      
REMARK 465     GLN A   106                                                      
REMARK 465     SER A   107                                                      
REMARK 465     LEU A   108                                                      
REMARK 465     LYS A   109                                                      
REMARK 465     ILE A   110                                                      
REMARK 465     ALA A   111                                                      
REMARK 465     ILE A   112                                                      
REMARK 465     LYS A   113                                                      
REMARK 465     GLU A   114                                                      
REMARK 465     LEU A   115                                                      
REMARK 465     GLN A   116                                                      
REMARK 465     ASN A   117                                                      
REMARK 465     SER A   118                                                      
REMARK 465     CYS A   119                                                      
REMARK 465     SER A   120                                                      
REMARK 465     SER A   121                                                      
REMARK 465     SER A   122                                                      
REMARK 465     LEU A   123                                                      
REMARK 465     ILE A   124                                                      
REMARK 465     LEU A   125                                                      
REMARK 465     GLU A   126                                                      
REMARK 465     LEU A   127                                                      
REMARK 465     PRO A   128                                                      
REMARK 465     HIS A   129                                                      
REMARK 465     ASP A   130                                                      
REMARK 465     TYR A   131                                                      
REMARK 465     ILE A   132                                                      
REMARK 465     ARG A   133                                                      
REMARK 465     LYS A   134                                                      
REMARK 465     ILE A   135                                                      
REMARK 465     ASP A   136                                                      
REMARK 465     VAL A   137                                                      
REMARK 465     LEU A   138                                                      
REMARK 465     LEU A   139                                                      
REMARK 465     THR A   140                                                      
REMARK 465     SER A   141                                                      
REMARK 465     ILE A   142                                                      
REMARK 465     ASP A   143                                                      
REMARK 465     SER A   144                                                      
REMARK 465     ALA A   145                                                      
REMARK 465     ILE A   146                                                      
REMARK 465     GLN A   147                                                      
REMARK 465     ARG A   148                                                      
REMARK 465     SER A   149                                                      
REMARK 465     SER A   150                                                      
REMARK 465     ASP A   151                                                      
REMARK 465     LEU A   152                                                      
REMARK 465     ASN A   153                                                      
REMARK 465     LYS A   154                                                      
REMARK 465     THR A   155                                                      
REMARK 465     ILE A   156                                                      
REMARK 465     ILE A   157                                                      
REMARK 465     LYS A   158                                                      
REMARK 465     GLN A   159                                                      
REMARK 465     LEU A   160                                                      
REMARK 465     ASN A   161                                                      
REMARK 465     LYS A   162                                                      
REMARK 465     LEU A   163                                                      
REMARK 465     ARG A   164                                                      
REMARK 465     SER A   165                                                      
REMARK 465     SER A   166                                                      
REMARK 465     LEU A   167                                                      
REMARK 465     SER A   168                                                      
REMARK 465     ARG A   169                                                      
REMARK 465     TYR A   170                                                      
REMARK 465     ILE A   171                                                      
REMARK 465     SER A   199                                                      
REMARK 465     PHE A   200                                                      
REMARK 465     VAL A   201                                                      
REMARK 465     SER A   202                                                      
REMARK 465     THR A   203                                                      
REMARK 465     ARG A   204                                                      
REMARK 465     ASN A   205                                                      
REMARK 465     LYS A   206                                                      
REMARK 465     GLN A   207                                                      
REMARK 465     TYR A   208                                                      
REMARK 465     PHE A   209                                                      
REMARK 465     LYS A   210                                                      
REMARK 465     ASN A   271                                                      
REMARK 465     PHE A   272                                                      
REMARK 465     TYR A   273                                                      
REMARK 465     LYS A   274                                                      
REMARK 465     LYS A   275                                                      
REMARK 465     GLU A   276                                                      
REMARK 465     SER A   277                                                      
REMARK 465     LYS A   278                                                      
REMARK 465     LYS A   279                                                      
REMARK 465     ASP A   280                                                      
REMARK 465     PHE A   304                                                      
REMARK 465     GLU A   305                                                      
REMARK 465     TYR A   306                                                      
REMARK 465     SER A   307                                                      
REMARK 465     ILE A   308                                                      
REMARK 465     TYR A   309                                                      
REMARK 465     SER A   310                                                      
REMARK 465     TYR A   311                                                      
REMARK 465     THR A   312                                                      
REMARK 465     LYS A   313                                                      
REMARK 465     ASN A   314                                                      
REMARK 465     VAL A   315                                                      
REMARK 465     SER A   316                                                      
REMARK 465     SER A   317                                                      
REMARK 465     LEU A   582                                                      
REMARK 465     HIS A   583                                                      
REMARK 465     ASN A   584                                                      
REMARK 465     PHE A   585                                                      
REMARK 465     HIS A   586                                                      
REMARK 465     TYR A   587                                                      
REMARK 465     LYS A   588                                                      
REMARK 465     SER A   589                                                      
REMARK 465     ASP A   590                                                      
REMARK 465     SER A   591                                                      
REMARK 465     GLU A   592                                                      
REMARK 465     SER A   593                                                      
REMARK 465     ASP A   594                                                      
REMARK 465     VAL A   595                                                      
REMARK 465     TYR A   596                                                      
REMARK 465     GLU A   597                                                      
REMARK 465     LYS A   598                                                      
REMARK 465     ILE A   599                                                      
REMARK 465     ALA A   600                                                      
REMARK 465     PHE A   601                                                      
REMARK 465     THR A   602                                                      
REMARK 465     LYS A   603                                                      
REMARK 465     TYR A   604                                                      
REMARK 465     PRO A   605                                                      
REMARK 465     SER A   606                                                      
REMARK 465     LEU A   607                                                      
REMARK 465     THR A   608                                                      
REMARK 465     LYS A   818                                                      
REMARK 465     GLY A   819                                                      
REMARK 465     ASN A   820                                                      
REMARK 465     MET C     1                                                      
REMARK 465     ILE C     2                                                      
REMARK 465     ALA C     3                                                      
REMARK 465     VAL C     4                                                      
REMARK 465     LYS C     5                                                      
REMARK 465     ASP C     6                                                      
REMARK 465     ILE C     7                                                      
REMARK 465     THR C     8                                                      
REMARK 465     ASP C     9                                                      
REMARK 465     LEU C    10                                                      
REMARK 465     ASN C    11                                                      
REMARK 465     ILE C    12                                                      
REMARK 465     GLN C    13                                                      
REMARK 465     ASP C    14                                                      
REMARK 465     ILE C    15                                                      
REMARK 465     ILE C    16                                                      
REMARK 465     SER C    17                                                      
REMARK 465     GLN C    18                                                      
REMARK 465     LEU C    19                                                      
REMARK 465     THR C    20                                                      
REMARK 465     SER C    21                                                      
REMARK 465     GLU C    22                                                      
REMARK 465     VAL C    23                                                      
REMARK 465     ILE C    24                                                      
REMARK 465     ASN C    25                                                      
REMARK 465     GLY C    26                                                      
REMARK 465     ASP C    27                                                      
REMARK 465     THR C    28                                                      
REMARK 465     THR C    29                                                      
REMARK 465     PRO C    30                                                      
REMARK 465     SER C    31                                                      
REMARK 465     SER C    32                                                      
REMARK 465     ALA C    33                                                      
REMARK 465     LYS C    34                                                      
REMARK 465     PHE C    35                                                      
REMARK 465     ALA C    36                                                      
REMARK 465     CYS C    37                                                      
REMARK 465     GLU C    38                                                      
REMARK 465     ILE C    39                                                      
REMARK 465     ASN C    40                                                      
REMARK 465     SER C    41                                                      
REMARK 465     TYR C    42                                                      
REMARK 465     ILE C    43                                                      
REMARK 465     ILE C    44                                                      
REMARK 465     ASN C    45                                                      
REMARK 465     TYR C    46                                                      
REMARK 465     ASN C    47                                                      
REMARK 465     LEU C    48                                                      
REMARK 465     SER C    49                                                      
REMARK 465     ASN C    50                                                      
REMARK 465     ILE C    51                                                      
REMARK 465     ASN C    52                                                      
REMARK 465     LEU C    53                                                      
REMARK 465     ILE C    54                                                      
REMARK 465     ASN C    55                                                      
REMARK 465     THR C    56                                                      
REMARK 465     GLN C    57                                                      
REMARK 465     LEU C    58                                                      
REMARK 465     LYS C    59                                                      
REMARK 465     ASN C    60                                                      
REMARK 465     THR C    61                                                      
REMARK 465     LYS C    62                                                      
REMARK 465     ILE C    63                                                      
REMARK 465     LEU C    64                                                      
REMARK 465     TYR C    65                                                      
REMARK 465     ARG C    66                                                      
REMARK 465     LYS C    67                                                      
REMARK 465     GLY C    68                                                      
REMARK 465     LEU C    69                                                      
REMARK 465     ILE C    70                                                      
REMARK 465     SER C    71                                                      
REMARK 465     LYS C    72                                                      
REMARK 465     LEU C    73                                                      
REMARK 465     ASP C    74                                                      
REMARK 465     TYR C    75                                                      
REMARK 465     GLU C    76                                                      
REMARK 465     LYS C    77                                                      
REMARK 465     TYR C    78                                                      
REMARK 465     LYS C    79                                                      
REMARK 465     ARG C    80                                                      
REMARK 465     TYR C    81                                                      
REMARK 465     CYS C    82                                                      
REMARK 465     ILE C    83                                                      
REMARK 465     ILE C    84                                                      
REMARK 465     SER C    85                                                      
REMARK 465     ARG C    86                                                      
REMARK 465     PHE C    87                                                      
REMARK 465     LYS C    88                                                      
REMARK 465     ASN C    89                                                      
REMARK 465     ASN C    90                                                      
REMARK 465     ILE C    91                                                      
REMARK 465     ASP C    92                                                      
REMARK 465     GLU C    93                                                      
REMARK 465     PHE C    94                                                      
REMARK 465     ILE C    95                                                      
REMARK 465     LEU C    96                                                      
REMARK 465     TYR C    97                                                      
REMARK 465     PHE C    98                                                      
REMARK 465     SER C    99                                                      
REMARK 465     THR C   100                                                      
REMARK 465     ASN C   101                                                      
REMARK 465     TYR C   102                                                      
REMARK 465     LYS C   103                                                      
REMARK 465     ASP C   104                                                      
REMARK 465     SER C   105                                                      
REMARK 465     GLN C   106                                                      
REMARK 465     SER C   107                                                      
REMARK 465     LEU C   108                                                      
REMARK 465     LYS C   109                                                      
REMARK 465     ILE C   110                                                      
REMARK 465     ALA C   111                                                      
REMARK 465     ILE C   112                                                      
REMARK 465     LYS C   113                                                      
REMARK 465     GLU C   114                                                      
REMARK 465     LEU C   115                                                      
REMARK 465     GLN C   116                                                      
REMARK 465     ASN C   117                                                      
REMARK 465     SER C   118                                                      
REMARK 465     CYS C   119                                                      
REMARK 465     SER C   120                                                      
REMARK 465     SER C   121                                                      
REMARK 465     SER C   122                                                      
REMARK 465     LEU C   123                                                      
REMARK 465     ILE C   124                                                      
REMARK 465     LEU C   125                                                      
REMARK 465     GLU C   126                                                      
REMARK 465     LEU C   127                                                      
REMARK 465     PRO C   128                                                      
REMARK 465     HIS C   129                                                      
REMARK 465     ASP C   130                                                      
REMARK 465     TYR C   131                                                      
REMARK 465     ILE C   132                                                      
REMARK 465     ARG C   133                                                      
REMARK 465     LYS C   134                                                      
REMARK 465     ILE C   135                                                      
REMARK 465     ASP C   136                                                      
REMARK 465     VAL C   137                                                      
REMARK 465     LEU C   138                                                      
REMARK 465     LEU C   139                                                      
REMARK 465     THR C   140                                                      
REMARK 465     SER C   141                                                      
REMARK 465     ILE C   142                                                      
REMARK 465     ASP C   143                                                      
REMARK 465     SER C   144                                                      
REMARK 465     ALA C   145                                                      
REMARK 465     ILE C   146                                                      
REMARK 465     GLN C   147                                                      
REMARK 465     ARG C   148                                                      
REMARK 465     SER C   149                                                      
REMARK 465     SER C   150                                                      
REMARK 465     ASP C   151                                                      
REMARK 465     LEU C   152                                                      
REMARK 465     ASN C   153                                                      
REMARK 465     LYS C   154                                                      
REMARK 465     THR C   155                                                      
REMARK 465     ILE C   156                                                      
REMARK 465     ILE C   157                                                      
REMARK 465     LYS C   158                                                      
REMARK 465     GLN C   159                                                      
REMARK 465     LEU C   160                                                      
REMARK 465     ASN C   161                                                      
REMARK 465     LYS C   162                                                      
REMARK 465     LEU C   163                                                      
REMARK 465     ARG C   164                                                      
REMARK 465     SER C   165                                                      
REMARK 465     SER C   166                                                      
REMARK 465     LEU C   167                                                      
REMARK 465     SER C   168                                                      
REMARK 465     ARG C   169                                                      
REMARK 465     TYR C   170                                                      
REMARK 465     ILE C   171                                                      
REMARK 465     SER C   199                                                      
REMARK 465     PHE C   200                                                      
REMARK 465     VAL C   201                                                      
REMARK 465     SER C   202                                                      
REMARK 465     THR C   203                                                      
REMARK 465     ARG C   204                                                      
REMARK 465     ASN C   205                                                      
REMARK 465     LYS C   206                                                      
REMARK 465     GLN C   207                                                      
REMARK 465     TYR C   208                                                      
REMARK 465     PHE C   209                                                      
REMARK 465     LYS C   210                                                      
REMARK 465     ASN C   271                                                      
REMARK 465     PHE C   272                                                      
REMARK 465     TYR C   273                                                      
REMARK 465     LYS C   274                                                      
REMARK 465     LYS C   275                                                      
REMARK 465     GLU C   276                                                      
REMARK 465     SER C   277                                                      
REMARK 465     LYS C   278                                                      
REMARK 465     LYS C   279                                                      
REMARK 465     ASP C   280                                                      
REMARK 465     PHE C   304                                                      
REMARK 465     GLU C   305                                                      
REMARK 465     TYR C   306                                                      
REMARK 465     SER C   307                                                      
REMARK 465     ILE C   308                                                      
REMARK 465     TYR C   309                                                      
REMARK 465     SER C   310                                                      
REMARK 465     TYR C   311                                                      
REMARK 465     THR C   312                                                      
REMARK 465     LYS C   313                                                      
REMARK 465     ASN C   314                                                      
REMARK 465     VAL C   315                                                      
REMARK 465     SER C   316                                                      
REMARK 465     SER C   317                                                      
REMARK 465     LEU C   582                                                      
REMARK 465     HIS C   583                                                      
REMARK 465     ASN C   584                                                      
REMARK 465     PHE C   585                                                      
REMARK 465     HIS C   586                                                      
REMARK 465     TYR C   587                                                      
REMARK 465     LYS C   588                                                      
REMARK 465     SER C   589                                                      
REMARK 465     ASP C   590                                                      
REMARK 465     SER C   591                                                      
REMARK 465     GLU C   592                                                      
REMARK 465     SER C   593                                                      
REMARK 465     ASP C   594                                                      
REMARK 465     VAL C   595                                                      
REMARK 465     TYR C   596                                                      
REMARK 465     GLU C   597                                                      
REMARK 465     LYS C   598                                                      
REMARK 465     ILE C   599                                                      
REMARK 465     ALA C   600                                                      
REMARK 465     PHE C   601                                                      
REMARK 465     THR C   602                                                      
REMARK 465     LYS C   603                                                      
REMARK 465     TYR C   604                                                      
REMARK 465     PRO C   605                                                      
REMARK 465     SER C   606                                                      
REMARK 465     LEU C   607                                                      
REMARK 465     THR C   608                                                      
REMARK 465     LYS C   818                                                      
REMARK 465     GLY C   819                                                      
REMARK 465     ASN C   820                                                      
REMARK 465     MET E     1                                                      
REMARK 465     ILE E     2                                                      
REMARK 465     ALA E     3                                                      
REMARK 465     VAL E     4                                                      
REMARK 465     LYS E     5                                                      
REMARK 465     ASP E     6                                                      
REMARK 465     ILE E     7                                                      
REMARK 465     THR E     8                                                      
REMARK 465     ASP E     9                                                      
REMARK 465     LEU E    10                                                      
REMARK 465     ASN E    11                                                      
REMARK 465     ILE E    12                                                      
REMARK 465     GLN E    13                                                      
REMARK 465     ASP E    14                                                      
REMARK 465     ILE E    15                                                      
REMARK 465     ILE E    16                                                      
REMARK 465     SER E    17                                                      
REMARK 465     GLN E    18                                                      
REMARK 465     LEU E    19                                                      
REMARK 465     THR E    20                                                      
REMARK 465     SER E    21                                                      
REMARK 465     GLU E    22                                                      
REMARK 465     VAL E    23                                                      
REMARK 465     ILE E    24                                                      
REMARK 465     ASN E    25                                                      
REMARK 465     GLY E    26                                                      
REMARK 465     ASP E    27                                                      
REMARK 465     THR E    28                                                      
REMARK 465     THR E    29                                                      
REMARK 465     PRO E    30                                                      
REMARK 465     SER E    31                                                      
REMARK 465     SER E    32                                                      
REMARK 465     ALA E    33                                                      
REMARK 465     LYS E    34                                                      
REMARK 465     PHE E    35                                                      
REMARK 465     ALA E    36                                                      
REMARK 465     CYS E    37                                                      
REMARK 465     GLU E    38                                                      
REMARK 465     ILE E    39                                                      
REMARK 465     ASN E    40                                                      
REMARK 465     SER E    41                                                      
REMARK 465     TYR E    42                                                      
REMARK 465     ILE E    43                                                      
REMARK 465     ILE E    44                                                      
REMARK 465     ASN E    45                                                      
REMARK 465     TYR E    46                                                      
REMARK 465     ASN E    47                                                      
REMARK 465     LEU E    48                                                      
REMARK 465     SER E    49                                                      
REMARK 465     ASN E    50                                                      
REMARK 465     ILE E    51                                                      
REMARK 465     ASN E    52                                                      
REMARK 465     LEU E    53                                                      
REMARK 465     ILE E    54                                                      
REMARK 465     ASN E    55                                                      
REMARK 465     THR E    56                                                      
REMARK 465     GLN E    57                                                      
REMARK 465     LEU E    58                                                      
REMARK 465     LYS E    59                                                      
REMARK 465     ASN E    60                                                      
REMARK 465     THR E    61                                                      
REMARK 465     LYS E    62                                                      
REMARK 465     ILE E    63                                                      
REMARK 465     LEU E    64                                                      
REMARK 465     TYR E    65                                                      
REMARK 465     ARG E    66                                                      
REMARK 465     LYS E    67                                                      
REMARK 465     GLY E    68                                                      
REMARK 465     LEU E    69                                                      
REMARK 465     ILE E    70                                                      
REMARK 465     SER E    71                                                      
REMARK 465     LYS E    72                                                      
REMARK 465     LEU E    73                                                      
REMARK 465     ASP E    74                                                      
REMARK 465     TYR E    75                                                      
REMARK 465     GLU E    76                                                      
REMARK 465     LYS E    77                                                      
REMARK 465     TYR E    78                                                      
REMARK 465     LYS E    79                                                      
REMARK 465     ARG E    80                                                      
REMARK 465     TYR E    81                                                      
REMARK 465     CYS E    82                                                      
REMARK 465     ILE E    83                                                      
REMARK 465     ILE E    84                                                      
REMARK 465     SER E    85                                                      
REMARK 465     ARG E    86                                                      
REMARK 465     PHE E    87                                                      
REMARK 465     LYS E    88                                                      
REMARK 465     ASN E    89                                                      
REMARK 465     ASN E    90                                                      
REMARK 465     ILE E    91                                                      
REMARK 465     ASP E    92                                                      
REMARK 465     GLU E    93                                                      
REMARK 465     PHE E    94                                                      
REMARK 465     ILE E    95                                                      
REMARK 465     LEU E    96                                                      
REMARK 465     TYR E    97                                                      
REMARK 465     PHE E    98                                                      
REMARK 465     SER E    99                                                      
REMARK 465     THR E   100                                                      
REMARK 465     ASN E   101                                                      
REMARK 465     TYR E   102                                                      
REMARK 465     LYS E   103                                                      
REMARK 465     ASP E   104                                                      
REMARK 465     SER E   105                                                      
REMARK 465     GLN E   106                                                      
REMARK 465     SER E   107                                                      
REMARK 465     LEU E   108                                                      
REMARK 465     LYS E   109                                                      
REMARK 465     ILE E   110                                                      
REMARK 465     ALA E   111                                                      
REMARK 465     ILE E   112                                                      
REMARK 465     LYS E   113                                                      
REMARK 465     GLU E   114                                                      
REMARK 465     LEU E   115                                                      
REMARK 465     GLN E   116                                                      
REMARK 465     ASN E   117                                                      
REMARK 465     SER E   118                                                      
REMARK 465     CYS E   119                                                      
REMARK 465     SER E   120                                                      
REMARK 465     SER E   121                                                      
REMARK 465     SER E   122                                                      
REMARK 465     LEU E   123                                                      
REMARK 465     ILE E   124                                                      
REMARK 465     LEU E   125                                                      
REMARK 465     GLU E   126                                                      
REMARK 465     LEU E   127                                                      
REMARK 465     PRO E   128                                                      
REMARK 465     HIS E   129                                                      
REMARK 465     ASP E   130                                                      
REMARK 465     TYR E   131                                                      
REMARK 465     ILE E   132                                                      
REMARK 465     ARG E   133                                                      
REMARK 465     LYS E   134                                                      
REMARK 465     ILE E   135                                                      
REMARK 465     ASP E   136                                                      
REMARK 465     VAL E   137                                                      
REMARK 465     LEU E   138                                                      
REMARK 465     LEU E   139                                                      
REMARK 465     THR E   140                                                      
REMARK 465     SER E   141                                                      
REMARK 465     ILE E   142                                                      
REMARK 465     ASP E   143                                                      
REMARK 465     SER E   144                                                      
REMARK 465     ALA E   145                                                      
REMARK 465     ILE E   146                                                      
REMARK 465     GLN E   147                                                      
REMARK 465     ARG E   148                                                      
REMARK 465     SER E   149                                                      
REMARK 465     SER E   150                                                      
REMARK 465     ASP E   151                                                      
REMARK 465     LEU E   152                                                      
REMARK 465     ASN E   153                                                      
REMARK 465     LYS E   154                                                      
REMARK 465     THR E   155                                                      
REMARK 465     ILE E   156                                                      
REMARK 465     ILE E   157                                                      
REMARK 465     LYS E   158                                                      
REMARK 465     GLN E   159                                                      
REMARK 465     LEU E   160                                                      
REMARK 465     ASN E   161                                                      
REMARK 465     LYS E   162                                                      
REMARK 465     LEU E   163                                                      
REMARK 465     ARG E   164                                                      
REMARK 465     SER E   165                                                      
REMARK 465     SER E   166                                                      
REMARK 465     LEU E   167                                                      
REMARK 465     SER E   168                                                      
REMARK 465     ARG E   169                                                      
REMARK 465     TYR E   170                                                      
REMARK 465     ILE E   171                                                      
REMARK 465     SER E   199                                                      
REMARK 465     PHE E   200                                                      
REMARK 465     VAL E   201                                                      
REMARK 465     SER E   202                                                      
REMARK 465     THR E   203                                                      
REMARK 465     ARG E   204                                                      
REMARK 465     ASN E   205                                                      
REMARK 465     LYS E   206                                                      
REMARK 465     GLN E   207                                                      
REMARK 465     TYR E   208                                                      
REMARK 465     PHE E   209                                                      
REMARK 465     LYS E   210                                                      
REMARK 465     ASN E   271                                                      
REMARK 465     PHE E   272                                                      
REMARK 465     TYR E   273                                                      
REMARK 465     LYS E   274                                                      
REMARK 465     LYS E   275                                                      
REMARK 465     GLU E   276                                                      
REMARK 465     SER E   277                                                      
REMARK 465     LYS E   278                                                      
REMARK 465     LYS E   279                                                      
REMARK 465     ASP E   280                                                      
REMARK 465     PHE E   304                                                      
REMARK 465     GLU E   305                                                      
REMARK 465     TYR E   306                                                      
REMARK 465     SER E   307                                                      
REMARK 465     ILE E   308                                                      
REMARK 465     TYR E   309                                                      
REMARK 465     SER E   310                                                      
REMARK 465     TYR E   311                                                      
REMARK 465     THR E   312                                                      
REMARK 465     LYS E   313                                                      
REMARK 465     ASN E   314                                                      
REMARK 465     VAL E   315                                                      
REMARK 465     SER E   316                                                      
REMARK 465     SER E   317                                                      
REMARK 465     LEU E   582                                                      
REMARK 465     HIS E   583                                                      
REMARK 465     ASN E   584                                                      
REMARK 465     PHE E   585                                                      
REMARK 465     HIS E   586                                                      
REMARK 465     TYR E   587                                                      
REMARK 465     LYS E   588                                                      
REMARK 465     SER E   589                                                      
REMARK 465     ASP E   590                                                      
REMARK 465     SER E   591                                                      
REMARK 465     GLU E   592                                                      
REMARK 465     SER E   593                                                      
REMARK 465     ASP E   594                                                      
REMARK 465     VAL E   595                                                      
REMARK 465     TYR E   596                                                      
REMARK 465     GLU E   597                                                      
REMARK 465     LYS E   598                                                      
REMARK 465     ILE E   599                                                      
REMARK 465     ALA E   600                                                      
REMARK 465     PHE E   601                                                      
REMARK 465     THR E   602                                                      
REMARK 465     LYS E   603                                                      
REMARK 465     TYR E   604                                                      
REMARK 465     PRO E   605                                                      
REMARK 465     SER E   606                                                      
REMARK 465     LEU E   607                                                      
REMARK 465     THR E   608                                                      
REMARK 465     LYS E   818                                                      
REMARK 465     GLY E   819                                                      
REMARK 465     ASN E   820                                                      
REMARK 465     MET B   -24                                                      
REMARK 465     ASP B   -23                                                      
REMARK 465     TYR B   -22                                                      
REMARK 465     LYS B   -21                                                      
REMARK 465     ASP B   -20                                                      
REMARK 465     ASP B   -19                                                      
REMARK 465     ASP B   -18                                                      
REMARK 465     ASP B   -17                                                      
REMARK 465     LYS B   -16                                                      
REMARK 465     ASP B   -15                                                      
REMARK 465     TYR B   -14                                                      
REMARK 465     LYS B   -13                                                      
REMARK 465     ASP B   -12                                                      
REMARK 465     ASP B   -11                                                      
REMARK 465     ASP B   -10                                                      
REMARK 465     ASP B    -9                                                      
REMARK 465     LYS B    -8                                                      
REMARK 465     ASP B    -7                                                      
REMARK 465     TYR B    -6                                                      
REMARK 465     LYS B    -5                                                      
REMARK 465     ASP B    -4                                                      
REMARK 465     ASP B    -3                                                      
REMARK 465     ASP B    -2                                                      
REMARK 465     ASP B    -1                                                      
REMARK 465     LYS B     0                                                      
REMARK 465     GLY B     1                                                      
REMARK 465     SER B     2                                                      
REMARK 465     VAL B   136                                                      
REMARK 465     ASN B   137                                                      
REMARK 465     LEU B   138                                                      
REMARK 465     ASN B   139                                                      
REMARK 465     ALA B   140                                                      
REMARK 465     GLU B   141                                                      
REMARK 465     GLY B   142                                                      
REMARK 465     LEU B   143                                                      
REMARK 465     ASP B   144                                                      
REMARK 465     VAL B   145                                                      
REMARK 465     ASN B   146                                                      
REMARK 465     ILE B   147                                                      
REMARK 465     LYS B   148                                                      
REMARK 465     GLY B   149                                                      
REMARK 465     SER B   150                                                      
REMARK 465     VAL B   151                                                      
REMARK 465     THR B   152                                                      
REMARK 465     ALA B   153                                                      
REMARK 465     SER B   154                                                      
REMARK 465     ILE B   155                                                      
REMARK 465     LYS B   156                                                      
REMARK 465     GLY B   157                                                      
REMARK 465     SER B   158                                                      
REMARK 465     ALA B   159                                                      
REMARK 465     ALA B   160                                                      
REMARK 465     THR B   161                                                      
REMARK 465     MET B   162                                                      
REMARK 465     VAL B   163                                                      
REMARK 465     GLY B   164                                                      
REMARK 465     MET D   -24                                                      
REMARK 465     ASP D   -23                                                      
REMARK 465     TYR D   -22                                                      
REMARK 465     LYS D   -21                                                      
REMARK 465     ASP D   -20                                                      
REMARK 465     ASP D   -19                                                      
REMARK 465     ASP D   -18                                                      
REMARK 465     ASP D   -17                                                      
REMARK 465     LYS D   -16                                                      
REMARK 465     ASP D   -15                                                      
REMARK 465     TYR D   -14                                                      
REMARK 465     LYS D   -13                                                      
REMARK 465     ASP D   -12                                                      
REMARK 465     ASP D   -11                                                      
REMARK 465     ASP D   -10                                                      
REMARK 465     ASP D    -9                                                      
REMARK 465     LYS D    -8                                                      
REMARK 465     ASP D    -7                                                      
REMARK 465     TYR D    -6                                                      
REMARK 465     LYS D    -5                                                      
REMARK 465     ASP D    -4                                                      
REMARK 465     ASP D    -3                                                      
REMARK 465     ASP D    -2                                                      
REMARK 465     ASP D    -1                                                      
REMARK 465     LYS D     0                                                      
REMARK 465     GLY D     1                                                      
REMARK 465     SER D     2                                                      
REMARK 465     VAL D   136                                                      
REMARK 465     ASN D   137                                                      
REMARK 465     LEU D   138                                                      
REMARK 465     ASN D   139                                                      
REMARK 465     ALA D   140                                                      
REMARK 465     GLU D   141                                                      
REMARK 465     GLY D   142                                                      
REMARK 465     LEU D   143                                                      
REMARK 465     ASP D   144                                                      
REMARK 465     VAL D   145                                                      
REMARK 465     ASN D   146                                                      
REMARK 465     ILE D   147                                                      
REMARK 465     LYS D   148                                                      
REMARK 465     GLY D   149                                                      
REMARK 465     SER D   150                                                      
REMARK 465     VAL D   151                                                      
REMARK 465     THR D   152                                                      
REMARK 465     ALA D   153                                                      
REMARK 465     SER D   154                                                      
REMARK 465     ILE D   155                                                      
REMARK 465     LYS D   156                                                      
REMARK 465     GLY D   157                                                      
REMARK 465     SER D   158                                                      
REMARK 465     ALA D   159                                                      
REMARK 465     ALA D   160                                                      
REMARK 465     THR D   161                                                      
REMARK 465     MET D   162                                                      
REMARK 465     VAL D   163                                                      
REMARK 465     GLY D   164                                                      
REMARK 465     MET F   -24                                                      
REMARK 465     ASP F   -23                                                      
REMARK 465     TYR F   -22                                                      
REMARK 465     LYS F   -21                                                      
REMARK 465     ASP F   -20                                                      
REMARK 465     ASP F   -19                                                      
REMARK 465     ASP F   -18                                                      
REMARK 465     ASP F   -17                                                      
REMARK 465     LYS F   -16                                                      
REMARK 465     ASP F   -15                                                      
REMARK 465     TYR F   -14                                                      
REMARK 465     LYS F   -13                                                      
REMARK 465     ASP F   -12                                                      
REMARK 465     ASP F   -11                                                      
REMARK 465     ASP F   -10                                                      
REMARK 465     ASP F    -9                                                      
REMARK 465     LYS F    -8                                                      
REMARK 465     ASP F    -7                                                      
REMARK 465     TYR F    -6                                                      
REMARK 465     LYS F    -5                                                      
REMARK 465     ASP F    -4                                                      
REMARK 465     ASP F    -3                                                      
REMARK 465     ASP F    -2                                                      
REMARK 465     ASP F    -1                                                      
REMARK 465     LYS F     0                                                      
REMARK 465     GLY F     1                                                      
REMARK 465     SER F     2                                                      
REMARK 465     VAL F   136                                                      
REMARK 465     ASN F   137                                                      
REMARK 465     LEU F   138                                                      
REMARK 465     ASN F   139                                                      
REMARK 465     ALA F   140                                                      
REMARK 465     GLU F   141                                                      
REMARK 465     GLY F   142                                                      
REMARK 465     LEU F   143                                                      
REMARK 465     ASP F   144                                                      
REMARK 465     VAL F   145                                                      
REMARK 465     ASN F   146                                                      
REMARK 465     ILE F   147                                                      
REMARK 465     LYS F   148                                                      
REMARK 465     GLY F   149                                                      
REMARK 465     SER F   150                                                      
REMARK 465     VAL F   151                                                      
REMARK 465     THR F   152                                                      
REMARK 465     ALA F   153                                                      
REMARK 465     SER F   154                                                      
REMARK 465     ILE F   155                                                      
REMARK 465     LYS F   156                                                      
REMARK 465     GLY F   157                                                      
REMARK 465     SER F   158                                                      
REMARK 465     ALA F   159                                                      
REMARK 465     ALA F   160                                                      
REMARK 465     THR F   161                                                      
REMARK 465     MET F   162                                                      
REMARK 465     VAL F   163                                                      
REMARK 465     GLY F   164                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     TYR A 173    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     ASN A 174    CG   OD1  ND2                                       
REMARK 470     ASN A 175    CG   OD1  ND2                                       
REMARK 470     ILE A 198    CG1  CG2  CD1                                       
REMARK 470     TYR A 243    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     ILE A 244    CG1  CG2  CD1                                       
REMARK 470     HIS A 281    CG   ND1  CD2  CE1  NE2                             
REMARK 470     ASN A 510    CG   OD1  ND2                                       
REMARK 470     ASP A 511    CG   OD1  OD2                                       
REMARK 470     ASP A 512    CG   OD1  OD2                                       
REMARK 470     LYS A 513    CG   CD   CE   NZ                                   
REMARK 470     HIS A 609    CG   ND1  CD2  CE1  NE2                             
REMARK 470     TYR C 173    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     ASN C 174    CG   OD1  ND2                                       
REMARK 470     ASN C 175    CG   OD1  ND2                                       
REMARK 470     ILE C 198    CG1  CG2  CD1                                       
REMARK 470     TYR C 243    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     ILE C 244    CG1  CG2  CD1                                       
REMARK 470     HIS C 281    CG   ND1  CD2  CE1  NE2                             
REMARK 470     ASN C 510    CG   OD1  ND2                                       
REMARK 470     ASP C 511    CG   OD1  OD2                                       
REMARK 470     ASP C 512    CG   OD1  OD2                                       
REMARK 470     LYS C 513    CG   CD   CE   NZ                                   
REMARK 470     HIS C 609    CG   ND1  CD2  CE1  NE2                             
REMARK 470     TYR E 173    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     ASN E 174    CG   OD1  ND2                                       
REMARK 470     ASN E 175    CG   OD1  ND2                                       
REMARK 470     ILE E 198    CG1  CG2  CD1                                       
REMARK 470     TYR E 243    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     ILE E 244    CG1  CG2  CD1                                       
REMARK 470     HIS E 281    CG   ND1  CD2  CE1  NE2                             
REMARK 470     ASN E 510    CG   OD1  ND2                                       
REMARK 470     ASP E 511    CG   OD1  OD2                                       
REMARK 470     ASP E 512    CG   OD1  OD2                                       
REMARK 470     LYS E 513    CG   CD   CE   NZ                                   
REMARK 470     HIS E 609    CG   ND1  CD2  CE1  NE2                             
REMARK 470     ASP B  82    CG   OD1  OD2                                       
REMARK 470     ASN B 130    CG   OD1  ND2                                       
REMARK 470     ILE B 132    CG1  CG2  CD1                                       
REMARK 470     LYS B 133    CG   CD   CE   NZ                                   
REMARK 470     ASP B 135    CG   OD1  OD2                                       
REMARK 470     ASP D  82    CG   OD1  OD2                                       
REMARK 470     ASN D 130    CG   OD1  ND2                                       
REMARK 470     ILE D 132    CG1  CG2  CD1                                       
REMARK 470     LYS D 133    CG   CD   CE   NZ                                   
REMARK 470     ASP D 135    CG   OD1  OD2                                       
REMARK 470     ASP F  82    CG   OD1  OD2                                       
REMARK 470     ASN F 130    CG   OD1  ND2                                       
REMARK 470     ILE F 132    CG1  CG2  CD1                                       
REMARK 470     LYS F 133    CG   CD   CE   NZ                                   
REMARK 470     ASP F 135    CG   OD1  OD2                                       
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    ASN A 212       14.11     59.98                                   
REMARK 500    LYS A 217     -158.16   -146.19                                   
REMARK 500    ASN A 218      109.82    -41.92                                   
REMARK 500    LYS A 336       52.59    -95.00                                   
REMARK 500    PHE A 357       71.35   -117.53                                   
REMARK 500    ARG A 386     -168.93   -126.30                                   
REMARK 500    GLN A 421     -169.02   -126.01                                   
REMARK 500    PRO A 443       47.61    -74.85                                   
REMARK 500    PHE A 492     -168.10    -79.92                                   
REMARK 500    PHE A 521      117.08   -163.55                                   
REMARK 500    LEU A 534     -169.47   -124.79                                   
REMARK 500    THR A 536       49.74    -91.73                                   
REMARK 500    SER A 541     -168.92   -127.01                                   
REMARK 500    ASN A 548       30.09    -94.88                                   
REMARK 500    ASP A 555       34.36    -98.61                                   
REMARK 500    LYS A 557     -158.65    -85.94                                   
REMARK 500    SER A 558      151.79    -47.08                                   
REMARK 500    SER A 652       40.46   -104.88                                   
REMARK 500    ALA A 655     -168.94   -125.64                                   
REMARK 500    ASN A 661       48.41   -142.12                                   
REMARK 500    GLU A 671       -3.41     66.98                                   
REMARK 500    GLN A 673       65.33     29.62                                   
REMARK 500    SER A 686       71.04     57.04                                   
REMARK 500    ASP A 689       17.91     59.13                                   
REMARK 500    SER A 706       51.76    -94.25                                   
REMARK 500    ILE A 719      -63.46   -121.66                                   
REMARK 500    ASN A 720       46.73    -88.99                                   
REMARK 500    SER A 721     -165.12   -164.92                                   
REMARK 500    ALA A 722     -159.56   -148.99                                   
REMARK 500    ALA A 761       18.70     59.49                                   
REMARK 500    LYS A 774       -6.61     72.90                                   
REMARK 500    ASN A 776       50.55    -96.95                                   
REMARK 500    MET A 779       62.96   -101.33                                   
REMARK 500    ASN C 212       14.13     59.95                                   
REMARK 500    LYS C 217     -158.11   -146.18                                   
REMARK 500    ASN C 218      109.73    -41.90                                   
REMARK 500    LYS C 336       52.65    -95.08                                   
REMARK 500    PHE C 357       71.39   -117.51                                   
REMARK 500    ARG C 386     -168.91   -126.31                                   
REMARK 500    GLN C 421     -168.98   -125.99                                   
REMARK 500    PRO C 443       47.70    -74.91                                   
REMARK 500    PHE C 492     -168.10    -79.95                                   
REMARK 500    PHE C 521      117.08   -163.57                                   
REMARK 500    LEU C 534     -169.50   -124.82                                   
REMARK 500    THR C 536       49.72    -91.71                                   
REMARK 500    SER C 541     -168.84   -127.12                                   
REMARK 500    ASN C 548       30.05    -94.82                                   
REMARK 500    ASP C 555       34.33    -98.54                                   
REMARK 500    LYS C 557     -158.62    -85.88                                   
REMARK 500    SER C 558      151.75    -47.13                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     126 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS                                         
REMARK 500                                                                      
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH          
REMARK 500 CIS AND TRANS CONFORMATION.  CIS BONDS, IF ANY, ARE LISTED           
REMARK 500 ON CISPEP RECORDS.  TRANS IS DEFINED AS 180 +/- 30 AND               
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.                                  
REMARK 500                                 MODEL     OMEGA                      
REMARK 500 ASN A  218     PRO A  219                 -141.81                    
REMARK 500 PHE A  672     GLN A  673                  149.22                    
REMARK 500 GLU A  674     ASN A  675                 -145.71                    
REMARK 500 ASN A  675     GLY A  676                  146.45                    
REMARK 500 LEU A  715     LYS A  716                  145.87                    
REMARK 500 ASN C  218     PRO C  219                 -141.75                    
REMARK 500 PHE C  672     GLN C  673                  149.19                    
REMARK 500 GLU C  674     ASN C  675                 -145.65                    
REMARK 500 ASN C  675     GLY C  676                  146.38                    
REMARK 500 LEU C  715     LYS C  716                  145.83                    
REMARK 500 ASN E  218     PRO E  219                 -141.80                    
REMARK 500 PHE E  672     GLN E  673                  149.19                    
REMARK 500 GLU E  674     ASN E  675                 -145.67                    
REMARK 500 ASN E  675     GLY E  676                  146.46                    
REMARK 500 LEU E  715     LYS E  716                  145.88                    
REMARK 500 LYS B   87     ILE B   88                  149.11                    
REMARK 500 LYS D   87     ILE D   88                  149.02                    
REMARK 500 LYS F   87     ILE F   88                  149.11                    
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: EMD-20695   RELATED DB: EMDB                             
REMARK 900 RELATED ID: EMD-20696   RELATED DB: EMDB                             
REMARK 900 RELATED ID: EMD-20698   RELATED DB: EMDB                             
DBREF  6U9E A    1   820  UNP    Q7X3I9   Q7X3I9_FRANO     1    820             
DBREF  6U9E C    1   820  UNP    Q7X3I9   Q7X3I9_FRANO     1    820             
DBREF  6U9E E    1   820  UNP    Q7X3I9   Q7X3I9_FRANO     1    820             
DBREF  6U9E B    2   164  UNP    Q7X3I8   Q7X3I8_FRANO     2    164             
DBREF  6U9E D    2   164  UNP    Q7X3I8   Q7X3I8_FRANO     2    164             
DBREF  6U9E F    2   164  UNP    Q7X3I8   Q7X3I8_FRANO     2    164             
SEQADV 6U9E MET B  -24  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E ASP B  -23  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E TYR B  -22  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E LYS B  -21  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E ASP B  -20  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E ASP B  -19  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E ASP B  -18  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E ASP B  -17  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E LYS B  -16  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E ASP B  -15  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E TYR B  -14  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E LYS B  -13  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E ASP B  -12  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E ASP B  -11  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E ASP B  -10  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E ASP B   -9  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E LYS B   -8  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E ASP B   -7  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E TYR B   -6  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E LYS B   -5  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E ASP B   -4  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E ASP B   -3  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E ASP B   -2  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E ASP B   -1  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E LYS B    0  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E GLY B    1  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E MET D  -24  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E ASP D  -23  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E TYR D  -22  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E LYS D  -21  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E ASP D  -20  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E ASP D  -19  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E ASP D  -18  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E ASP D  -17  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E LYS D  -16  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E ASP D  -15  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E TYR D  -14  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E LYS D  -13  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E ASP D  -12  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E ASP D  -11  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E ASP D  -10  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E ASP D   -9  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E LYS D   -8  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E ASP D   -7  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E TYR D   -6  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E LYS D   -5  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E ASP D   -4  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E ASP D   -3  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E ASP D   -2  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E ASP D   -1  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E LYS D    0  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E GLY D    1  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E MET F  -24  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E ASP F  -23  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E TYR F  -22  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E LYS F  -21  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E ASP F  -20  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E ASP F  -19  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E ASP F  -18  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E ASP F  -17  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E LYS F  -16  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E ASP F  -15  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E TYR F  -14  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E LYS F  -13  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E ASP F  -12  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E ASP F  -11  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E ASP F  -10  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E ASP F   -9  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E LYS F   -8  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E ASP F   -7  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E TYR F   -6  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E LYS F   -5  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E ASP F   -4  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E ASP F   -3  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E ASP F   -2  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E ASP F   -1  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E LYS F    0  UNP  Q7X3I8              EXPRESSION TAG                 
SEQADV 6U9E GLY F    1  UNP  Q7X3I8              EXPRESSION TAG                 
SEQRES   1 A  820  MET ILE ALA VAL LYS ASP ILE THR ASP LEU ASN ILE GLN          
SEQRES   2 A  820  ASP ILE ILE SER GLN LEU THR SER GLU VAL ILE ASN GLY          
SEQRES   3 A  820  ASP THR THR PRO SER SER ALA LYS PHE ALA CYS GLU ILE          
SEQRES   4 A  820  ASN SER TYR ILE ILE ASN TYR ASN LEU SER ASN ILE ASN          
SEQRES   5 A  820  LEU ILE ASN THR GLN LEU LYS ASN THR LYS ILE LEU TYR          
SEQRES   6 A  820  ARG LYS GLY LEU ILE SER LYS LEU ASP TYR GLU LYS TYR          
SEQRES   7 A  820  LYS ARG TYR CYS ILE ILE SER ARG PHE LYS ASN ASN ILE          
SEQRES   8 A  820  ASP GLU PHE ILE LEU TYR PHE SER THR ASN TYR LYS ASP          
SEQRES   9 A  820  SER GLN SER LEU LYS ILE ALA ILE LYS GLU LEU GLN ASN          
SEQRES  10 A  820  SER CYS SER SER SER LEU ILE LEU GLU LEU PRO HIS ASP          
SEQRES  11 A  820  TYR ILE ARG LYS ILE ASP VAL LEU LEU THR SER ILE ASP          
SEQRES  12 A  820  SER ALA ILE GLN ARG SER SER ASP LEU ASN LYS THR ILE          
SEQRES  13 A  820  ILE LYS GLN LEU ASN LYS LEU ARG SER SER LEU SER ARG          
SEQRES  14 A  820  TYR ILE GLY TYR ASN ASN VAL LEU GLN LYS GLN GLU ILE          
SEQRES  15 A  820  THR ILE ASN ILE LYS PRO ILE ASN LYS ASN PHE GLU LEU          
SEQRES  16 A  820  GLU ASP ILE SER PHE VAL SER THR ARG ASN LYS GLN TYR          
SEQRES  17 A  820  PHE LYS HIS ASN SER LEU THR LEU LYS ASN PRO HIS ILE          
SEQRES  18 A  820  GLU LYS LEU GLU VAL CYS GLU ASN ILE TYR GLY ILE ASN          
SEQRES  19 A  820  GLY TRP LEU THR PHE ASP LEU ALA TYR ILE ASN ASN HIS          
SEQRES  20 A  820  LYS ASP PHE ASN PHE LEU LEU SER PRO ASN GLN PRO ILE          
SEQRES  21 A  820  LEU LEU ASP ILE GLN ILE ASN ASP SER PHE ASN PHE TYR          
SEQRES  22 A  820  LYS LYS GLU SER LYS LYS ASP HIS HIS LYS ARG THR THR          
SEQRES  23 A  820  ARG PHE ILE ALA ILE GLY PHE ASN SER ASN SER ILE ASP          
SEQRES  24 A  820  ILE HIS GLU ASN PHE GLU TYR SER ILE TYR SER TYR THR          
SEQRES  25 A  820  LYS ASN VAL SER SER GLY VAL LYS LYS PHE LYS ILE GLN          
SEQRES  26 A  820  PHE HIS ASP PRO LEU LYS ALA LEU TRP THR LYS HIS LYS          
SEQRES  27 A  820  PRO SER TYR ILE ALA LEU ASN LYS SER LEU ASP ASP ILE          
SEQRES  28 A  820  PHE LYS ASP ASN PHE PHE PHE ASP SER LEU PHE SER LEU          
SEQRES  29 A  820  ASP THR ASN LYS SER ASN ASN LEU LYS ILE ARG ILE PRO          
SEQRES  30 A  820  GLN ALA PHE ILE SER THR VAL ASN ARG ASN PHE TYR ASP          
SEQRES  31 A  820  PHE PHE ILE GLN GLN LEU GLU GLN ASN LYS CYS TYR LEU          
SEQRES  32 A  820  LYS TYR PHE CYS ASP LYS LYS SER GLY LYS VAL SER TYR          
SEQRES  33 A  820  HIS VAL VAL ASP GLN VAL ASP ASN ASP LEU GLN ARG ASN          
SEQRES  34 A  820  ILE VAL ASN SER ASP GLU ASP LEU LYS ASP LYS LEU SER          
SEQRES  35 A  820  PRO TYR ASP ILE SER CYS PHE LYS LYS GLN ILE LEU ILE          
SEQRES  36 A  820  SER ASN LYS SER ASN PHE TYR VAL LYS GLU LYS ASN ILE          
SEQRES  37 A  820  CYS PRO ASP VAL THR LEU ASN THR GLN ARG LYS GLU ASP          
SEQRES  38 A  820  ARG LYS ILE SER ASP THR LEU VAL LYS PRO PHE SER SER          
SEQRES  39 A  820  ILE LEU LYS ASP ASN LEU GLN SER VAL GLU TYR ILE GLN          
SEQRES  40 A  820  SER ASN ASN ASP ASP LYS GLN GLU ILE ILE THR THR GLY          
SEQRES  41 A  820  PHE GLU ILE LEU LEU THR SER ARG ASN THR LEU PRO PHE          
SEQRES  42 A  820  LEU ASP THR GLU ILE THR LEU SER LYS LEU ASP ASN ASP          
SEQRES  43 A  820  GLN ASN TYR LEU LEU GLY ALA THR ASP ILE LYS SER LEU          
SEQRES  44 A  820  TYR ILE SER GLN ARG LYS LEU LEU PHE LYS ARG SER LYS          
SEQRES  45 A  820  TYR CYS SER LYS GLN LEU TYR GLU ASN LEU HIS ASN PHE          
SEQRES  46 A  820  HIS TYR LYS SER ASP SER GLU SER ASP VAL TYR GLU LYS          
SEQRES  47 A  820  ILE ALA PHE THR LYS TYR PRO SER LEU THR HIS ASP ASN          
SEQRES  48 A  820  SER ILE THR TYR LYS ILE LYS ASP TYR SER ASN LEU THR          
SEQRES  49 A  820  PRO GLU TYR PRO LYS TYR LYS SER PHE SER ASN PHE TYR          
SEQRES  50 A  820  ILE ASN GLY ARG ILE THR ILE GLY GLU ASN VAL ASN ASN          
SEQRES  51 A  820  ASP SER LYS LYS ALA TYR LYS PHE PHE LYS ASN HIS LYS          
SEQRES  52 A  820  PRO GLU GLU SER SER ILE ALA GLU PHE GLN GLU ASN GLY          
SEQRES  53 A  820  GLU LYS GLY THR SER ALA ILE LEU ASN SER LYS ALA ASP          
SEQRES  54 A  820  ILE LEU TYR ALA ILE GLU ILE ALA LYS GLU MET LEU SER          
SEQRES  55 A  820  ASP LYS SER SER ASP LYS PRO ILE ILE TYR LEU PRO LEU          
SEQRES  56 A  820  LYS VAL ASN ILE ASN SER ALA ASN ASN GLN PHE ILE PRO          
SEQRES  57 A  820  LEU ARG ASN ASP ASP ILE ILE LEU ILE GLU ILE GLN SER          
SEQRES  58 A  820  PHE THR LYS GLY GLU ILE ILE GLU LEU ILE SER ASN SER          
SEQRES  59 A  820  ALA ILE SER THR LYS LYS ALA GLN GLN GLN LEU LEU GLN          
SEQRES  60 A  820  ARG GLN LEU LEU GLY SER LYS GLU ASN CYS GLU MET ALA          
SEQRES  61 A  820  TYR THR GLN THR SER ASP SER GLU THR PHE SER LEU THR          
SEQRES  62 A  820  GLN VAL ASN GLU ASP CYS GLU ASN SER PHE LEU ILE ASN          
SEQRES  63 A  820  ASP LYS LYS GLY ILE PHE LEU ARG TYR LYS SER LYS GLY          
SEQRES  64 A  820  ASN                                                          
SEQRES   1 C  820  MET ILE ALA VAL LYS ASP ILE THR ASP LEU ASN ILE GLN          
SEQRES   2 C  820  ASP ILE ILE SER GLN LEU THR SER GLU VAL ILE ASN GLY          
SEQRES   3 C  820  ASP THR THR PRO SER SER ALA LYS PHE ALA CYS GLU ILE          
SEQRES   4 C  820  ASN SER TYR ILE ILE ASN TYR ASN LEU SER ASN ILE ASN          
SEQRES   5 C  820  LEU ILE ASN THR GLN LEU LYS ASN THR LYS ILE LEU TYR          
SEQRES   6 C  820  ARG LYS GLY LEU ILE SER LYS LEU ASP TYR GLU LYS TYR          
SEQRES   7 C  820  LYS ARG TYR CYS ILE ILE SER ARG PHE LYS ASN ASN ILE          
SEQRES   8 C  820  ASP GLU PHE ILE LEU TYR PHE SER THR ASN TYR LYS ASP          
SEQRES   9 C  820  SER GLN SER LEU LYS ILE ALA ILE LYS GLU LEU GLN ASN          
SEQRES  10 C  820  SER CYS SER SER SER LEU ILE LEU GLU LEU PRO HIS ASP          
SEQRES  11 C  820  TYR ILE ARG LYS ILE ASP VAL LEU LEU THR SER ILE ASP          
SEQRES  12 C  820  SER ALA ILE GLN ARG SER SER ASP LEU ASN LYS THR ILE          
SEQRES  13 C  820  ILE LYS GLN LEU ASN LYS LEU ARG SER SER LEU SER ARG          
SEQRES  14 C  820  TYR ILE GLY TYR ASN ASN VAL LEU GLN LYS GLN GLU ILE          
SEQRES  15 C  820  THR ILE ASN ILE LYS PRO ILE ASN LYS ASN PHE GLU LEU          
SEQRES  16 C  820  GLU ASP ILE SER PHE VAL SER THR ARG ASN LYS GLN TYR          
SEQRES  17 C  820  PHE LYS HIS ASN SER LEU THR LEU LYS ASN PRO HIS ILE          
SEQRES  18 C  820  GLU LYS LEU GLU VAL CYS GLU ASN ILE TYR GLY ILE ASN          
SEQRES  19 C  820  GLY TRP LEU THR PHE ASP LEU ALA TYR ILE ASN ASN HIS          
SEQRES  20 C  820  LYS ASP PHE ASN PHE LEU LEU SER PRO ASN GLN PRO ILE          
SEQRES  21 C  820  LEU LEU ASP ILE GLN ILE ASN ASP SER PHE ASN PHE TYR          
SEQRES  22 C  820  LYS LYS GLU SER LYS LYS ASP HIS HIS LYS ARG THR THR          
SEQRES  23 C  820  ARG PHE ILE ALA ILE GLY PHE ASN SER ASN SER ILE ASP          
SEQRES  24 C  820  ILE HIS GLU ASN PHE GLU TYR SER ILE TYR SER TYR THR          
SEQRES  25 C  820  LYS ASN VAL SER SER GLY VAL LYS LYS PHE LYS ILE GLN          
SEQRES  26 C  820  PHE HIS ASP PRO LEU LYS ALA LEU TRP THR LYS HIS LYS          
SEQRES  27 C  820  PRO SER TYR ILE ALA LEU ASN LYS SER LEU ASP ASP ILE          
SEQRES  28 C  820  PHE LYS ASP ASN PHE PHE PHE ASP SER LEU PHE SER LEU          
SEQRES  29 C  820  ASP THR ASN LYS SER ASN ASN LEU LYS ILE ARG ILE PRO          
SEQRES  30 C  820  GLN ALA PHE ILE SER THR VAL ASN ARG ASN PHE TYR ASP          
SEQRES  31 C  820  PHE PHE ILE GLN GLN LEU GLU GLN ASN LYS CYS TYR LEU          
SEQRES  32 C  820  LYS TYR PHE CYS ASP LYS LYS SER GLY LYS VAL SER TYR          
SEQRES  33 C  820  HIS VAL VAL ASP GLN VAL ASP ASN ASP LEU GLN ARG ASN          
SEQRES  34 C  820  ILE VAL ASN SER ASP GLU ASP LEU LYS ASP LYS LEU SER          
SEQRES  35 C  820  PRO TYR ASP ILE SER CYS PHE LYS LYS GLN ILE LEU ILE          
SEQRES  36 C  820  SER ASN LYS SER ASN PHE TYR VAL LYS GLU LYS ASN ILE          
SEQRES  37 C  820  CYS PRO ASP VAL THR LEU ASN THR GLN ARG LYS GLU ASP          
SEQRES  38 C  820  ARG LYS ILE SER ASP THR LEU VAL LYS PRO PHE SER SER          
SEQRES  39 C  820  ILE LEU LYS ASP ASN LEU GLN SER VAL GLU TYR ILE GLN          
SEQRES  40 C  820  SER ASN ASN ASP ASP LYS GLN GLU ILE ILE THR THR GLY          
SEQRES  41 C  820  PHE GLU ILE LEU LEU THR SER ARG ASN THR LEU PRO PHE          
SEQRES  42 C  820  LEU ASP THR GLU ILE THR LEU SER LYS LEU ASP ASN ASP          
SEQRES  43 C  820  GLN ASN TYR LEU LEU GLY ALA THR ASP ILE LYS SER LEU          
SEQRES  44 C  820  TYR ILE SER GLN ARG LYS LEU LEU PHE LYS ARG SER LYS          
SEQRES  45 C  820  TYR CYS SER LYS GLN LEU TYR GLU ASN LEU HIS ASN PHE          
SEQRES  46 C  820  HIS TYR LYS SER ASP SER GLU SER ASP VAL TYR GLU LYS          
SEQRES  47 C  820  ILE ALA PHE THR LYS TYR PRO SER LEU THR HIS ASP ASN          
SEQRES  48 C  820  SER ILE THR TYR LYS ILE LYS ASP TYR SER ASN LEU THR          
SEQRES  49 C  820  PRO GLU TYR PRO LYS TYR LYS SER PHE SER ASN PHE TYR          
SEQRES  50 C  820  ILE ASN GLY ARG ILE THR ILE GLY GLU ASN VAL ASN ASN          
SEQRES  51 C  820  ASP SER LYS LYS ALA TYR LYS PHE PHE LYS ASN HIS LYS          
SEQRES  52 C  820  PRO GLU GLU SER SER ILE ALA GLU PHE GLN GLU ASN GLY          
SEQRES  53 C  820  GLU LYS GLY THR SER ALA ILE LEU ASN SER LYS ALA ASP          
SEQRES  54 C  820  ILE LEU TYR ALA ILE GLU ILE ALA LYS GLU MET LEU SER          
SEQRES  55 C  820  ASP LYS SER SER ASP LYS PRO ILE ILE TYR LEU PRO LEU          
SEQRES  56 C  820  LYS VAL ASN ILE ASN SER ALA ASN ASN GLN PHE ILE PRO          
SEQRES  57 C  820  LEU ARG ASN ASP ASP ILE ILE LEU ILE GLU ILE GLN SER          
SEQRES  58 C  820  PHE THR LYS GLY GLU ILE ILE GLU LEU ILE SER ASN SER          
SEQRES  59 C  820  ALA ILE SER THR LYS LYS ALA GLN GLN GLN LEU LEU GLN          
SEQRES  60 C  820  ARG GLN LEU LEU GLY SER LYS GLU ASN CYS GLU MET ALA          
SEQRES  61 C  820  TYR THR GLN THR SER ASP SER GLU THR PHE SER LEU THR          
SEQRES  62 C  820  GLN VAL ASN GLU ASP CYS GLU ASN SER PHE LEU ILE ASN          
SEQRES  63 C  820  ASP LYS LYS GLY ILE PHE LEU ARG TYR LYS SER LYS GLY          
SEQRES  64 C  820  ASN                                                          
SEQRES   1 E  820  MET ILE ALA VAL LYS ASP ILE THR ASP LEU ASN ILE GLN          
SEQRES   2 E  820  ASP ILE ILE SER GLN LEU THR SER GLU VAL ILE ASN GLY          
SEQRES   3 E  820  ASP THR THR PRO SER SER ALA LYS PHE ALA CYS GLU ILE          
SEQRES   4 E  820  ASN SER TYR ILE ILE ASN TYR ASN LEU SER ASN ILE ASN          
SEQRES   5 E  820  LEU ILE ASN THR GLN LEU LYS ASN THR LYS ILE LEU TYR          
SEQRES   6 E  820  ARG LYS GLY LEU ILE SER LYS LEU ASP TYR GLU LYS TYR          
SEQRES   7 E  820  LYS ARG TYR CYS ILE ILE SER ARG PHE LYS ASN ASN ILE          
SEQRES   8 E  820  ASP GLU PHE ILE LEU TYR PHE SER THR ASN TYR LYS ASP          
SEQRES   9 E  820  SER GLN SER LEU LYS ILE ALA ILE LYS GLU LEU GLN ASN          
SEQRES  10 E  820  SER CYS SER SER SER LEU ILE LEU GLU LEU PRO HIS ASP          
SEQRES  11 E  820  TYR ILE ARG LYS ILE ASP VAL LEU LEU THR SER ILE ASP          
SEQRES  12 E  820  SER ALA ILE GLN ARG SER SER ASP LEU ASN LYS THR ILE          
SEQRES  13 E  820  ILE LYS GLN LEU ASN LYS LEU ARG SER SER LEU SER ARG          
SEQRES  14 E  820  TYR ILE GLY TYR ASN ASN VAL LEU GLN LYS GLN GLU ILE          
SEQRES  15 E  820  THR ILE ASN ILE LYS PRO ILE ASN LYS ASN PHE GLU LEU          
SEQRES  16 E  820  GLU ASP ILE SER PHE VAL SER THR ARG ASN LYS GLN TYR          
SEQRES  17 E  820  PHE LYS HIS ASN SER LEU THR LEU LYS ASN PRO HIS ILE          
SEQRES  18 E  820  GLU LYS LEU GLU VAL CYS GLU ASN ILE TYR GLY ILE ASN          
SEQRES  19 E  820  GLY TRP LEU THR PHE ASP LEU ALA TYR ILE ASN ASN HIS          
SEQRES  20 E  820  LYS ASP PHE ASN PHE LEU LEU SER PRO ASN GLN PRO ILE          
SEQRES  21 E  820  LEU LEU ASP ILE GLN ILE ASN ASP SER PHE ASN PHE TYR          
SEQRES  22 E  820  LYS LYS GLU SER LYS LYS ASP HIS HIS LYS ARG THR THR          
SEQRES  23 E  820  ARG PHE ILE ALA ILE GLY PHE ASN SER ASN SER ILE ASP          
SEQRES  24 E  820  ILE HIS GLU ASN PHE GLU TYR SER ILE TYR SER TYR THR          
SEQRES  25 E  820  LYS ASN VAL SER SER GLY VAL LYS LYS PHE LYS ILE GLN          
SEQRES  26 E  820  PHE HIS ASP PRO LEU LYS ALA LEU TRP THR LYS HIS LYS          
SEQRES  27 E  820  PRO SER TYR ILE ALA LEU ASN LYS SER LEU ASP ASP ILE          
SEQRES  28 E  820  PHE LYS ASP ASN PHE PHE PHE ASP SER LEU PHE SER LEU          
SEQRES  29 E  820  ASP THR ASN LYS SER ASN ASN LEU LYS ILE ARG ILE PRO          
SEQRES  30 E  820  GLN ALA PHE ILE SER THR VAL ASN ARG ASN PHE TYR ASP          
SEQRES  31 E  820  PHE PHE ILE GLN GLN LEU GLU GLN ASN LYS CYS TYR LEU          
SEQRES  32 E  820  LYS TYR PHE CYS ASP LYS LYS SER GLY LYS VAL SER TYR          
SEQRES  33 E  820  HIS VAL VAL ASP GLN VAL ASP ASN ASP LEU GLN ARG ASN          
SEQRES  34 E  820  ILE VAL ASN SER ASP GLU ASP LEU LYS ASP LYS LEU SER          
SEQRES  35 E  820  PRO TYR ASP ILE SER CYS PHE LYS LYS GLN ILE LEU ILE          
SEQRES  36 E  820  SER ASN LYS SER ASN PHE TYR VAL LYS GLU LYS ASN ILE          
SEQRES  37 E  820  CYS PRO ASP VAL THR LEU ASN THR GLN ARG LYS GLU ASP          
SEQRES  38 E  820  ARG LYS ILE SER ASP THR LEU VAL LYS PRO PHE SER SER          
SEQRES  39 E  820  ILE LEU LYS ASP ASN LEU GLN SER VAL GLU TYR ILE GLN          
SEQRES  40 E  820  SER ASN ASN ASP ASP LYS GLN GLU ILE ILE THR THR GLY          
SEQRES  41 E  820  PHE GLU ILE LEU LEU THR SER ARG ASN THR LEU PRO PHE          
SEQRES  42 E  820  LEU ASP THR GLU ILE THR LEU SER LYS LEU ASP ASN ASP          
SEQRES  43 E  820  GLN ASN TYR LEU LEU GLY ALA THR ASP ILE LYS SER LEU          
SEQRES  44 E  820  TYR ILE SER GLN ARG LYS LEU LEU PHE LYS ARG SER LYS          
SEQRES  45 E  820  TYR CYS SER LYS GLN LEU TYR GLU ASN LEU HIS ASN PHE          
SEQRES  46 E  820  HIS TYR LYS SER ASP SER GLU SER ASP VAL TYR GLU LYS          
SEQRES  47 E  820  ILE ALA PHE THR LYS TYR PRO SER LEU THR HIS ASP ASN          
SEQRES  48 E  820  SER ILE THR TYR LYS ILE LYS ASP TYR SER ASN LEU THR          
SEQRES  49 E  820  PRO GLU TYR PRO LYS TYR LYS SER PHE SER ASN PHE TYR          
SEQRES  50 E  820  ILE ASN GLY ARG ILE THR ILE GLY GLU ASN VAL ASN ASN          
SEQRES  51 E  820  ASP SER LYS LYS ALA TYR LYS PHE PHE LYS ASN HIS LYS          
SEQRES  52 E  820  PRO GLU GLU SER SER ILE ALA GLU PHE GLN GLU ASN GLY          
SEQRES  53 E  820  GLU LYS GLY THR SER ALA ILE LEU ASN SER LYS ALA ASP          
SEQRES  54 E  820  ILE LEU TYR ALA ILE GLU ILE ALA LYS GLU MET LEU SER          
SEQRES  55 E  820  ASP LYS SER SER ASP LYS PRO ILE ILE TYR LEU PRO LEU          
SEQRES  56 E  820  LYS VAL ASN ILE ASN SER ALA ASN ASN GLN PHE ILE PRO          
SEQRES  57 E  820  LEU ARG ASN ASP ASP ILE ILE LEU ILE GLU ILE GLN SER          
SEQRES  58 E  820  PHE THR LYS GLY GLU ILE ILE GLU LEU ILE SER ASN SER          
SEQRES  59 E  820  ALA ILE SER THR LYS LYS ALA GLN GLN GLN LEU LEU GLN          
SEQRES  60 E  820  ARG GLN LEU LEU GLY SER LYS GLU ASN CYS GLU MET ALA          
SEQRES  61 E  820  TYR THR GLN THR SER ASP SER GLU THR PHE SER LEU THR          
SEQRES  62 E  820  GLN VAL ASN GLU ASP CYS GLU ASN SER PHE LEU ILE ASN          
SEQRES  63 E  820  ASP LYS LYS GLY ILE PHE LEU ARG TYR LYS SER LYS GLY          
SEQRES  64 E  820  ASN                                                          
SEQRES   1 B  189  MET ASP TYR LYS ASP ASP ASP ASP LYS ASP TYR LYS ASP          
SEQRES   2 B  189  ASP ASP ASP LYS ASP TYR LYS ASP ASP ASP ASP LYS GLY          
SEQRES   3 B  189  SER LYS ALA ASP HIS ILE PHE ASN LEU GLU GLU GLN GLY          
SEQRES   4 B  189  LEU LEU ILE ASP ILE LYS ASP ASP SER LYS GLY CYS THR          
SEQRES   5 B  189  THR LYS LEU GLU SER SER GLY LYS ILE THR HIS ASN ALA          
SEQRES   6 B  189  THR GLU SER ILE GLU SER SER ALA ASP LYS GLN ILE ILE          
SEQRES   7 B  189  GLU ASN VAL LYS ASP SER LYS ILE SER ILE THR GLU LYS          
SEQRES   8 B  189  GLU ILE LEU LEU ALA THR LYS LYS SER SER ILE MET LEU          
SEQRES   9 B  189  SER GLU ASP LYS ILE VAL ILE LYS ILE GLY ASN SER LEU          
SEQRES  10 B  189  ILE ILE LEU ASP ASP SER ASN ILE SER LEU GLU SER ALA          
SEQRES  11 B  189  THR ILE ASN ILE LYS SER SER ALA ASN ILE ASN ILE GLN          
SEQRES  12 B  189  ALA SER GLN ASN ILE ASP ILE LYS SER LEU ASN ASN SER          
SEQRES  13 B  189  ILE LYS ALA ASP VAL ASN LEU ASN ALA GLU GLY LEU ASP          
SEQRES  14 B  189  VAL ASN ILE LYS GLY SER VAL THR ALA SER ILE LYS GLY          
SEQRES  15 B  189  SER ALA ALA THR MET VAL GLY                                  
SEQRES   1 D  189  MET ASP TYR LYS ASP ASP ASP ASP LYS ASP TYR LYS ASP          
SEQRES   2 D  189  ASP ASP ASP LYS ASP TYR LYS ASP ASP ASP ASP LYS GLY          
SEQRES   3 D  189  SER LYS ALA ASP HIS ILE PHE ASN LEU GLU GLU GLN GLY          
SEQRES   4 D  189  LEU LEU ILE ASP ILE LYS ASP ASP SER LYS GLY CYS THR          
SEQRES   5 D  189  THR LYS LEU GLU SER SER GLY LYS ILE THR HIS ASN ALA          
SEQRES   6 D  189  THR GLU SER ILE GLU SER SER ALA ASP LYS GLN ILE ILE          
SEQRES   7 D  189  GLU ASN VAL LYS ASP SER LYS ILE SER ILE THR GLU LYS          
SEQRES   8 D  189  GLU ILE LEU LEU ALA THR LYS LYS SER SER ILE MET LEU          
SEQRES   9 D  189  SER GLU ASP LYS ILE VAL ILE LYS ILE GLY ASN SER LEU          
SEQRES  10 D  189  ILE ILE LEU ASP ASP SER ASN ILE SER LEU GLU SER ALA          
SEQRES  11 D  189  THR ILE ASN ILE LYS SER SER ALA ASN ILE ASN ILE GLN          
SEQRES  12 D  189  ALA SER GLN ASN ILE ASP ILE LYS SER LEU ASN ASN SER          
SEQRES  13 D  189  ILE LYS ALA ASP VAL ASN LEU ASN ALA GLU GLY LEU ASP          
SEQRES  14 D  189  VAL ASN ILE LYS GLY SER VAL THR ALA SER ILE LYS GLY          
SEQRES  15 D  189  SER ALA ALA THR MET VAL GLY                                  
SEQRES   1 F  189  MET ASP TYR LYS ASP ASP ASP ASP LYS ASP TYR LYS ASP          
SEQRES   2 F  189  ASP ASP ASP LYS ASP TYR LYS ASP ASP ASP ASP LYS GLY          
SEQRES   3 F  189  SER LYS ALA ASP HIS ILE PHE ASN LEU GLU GLU GLN GLY          
SEQRES   4 F  189  LEU LEU ILE ASP ILE LYS ASP ASP SER LYS GLY CYS THR          
SEQRES   5 F  189  THR LYS LEU GLU SER SER GLY LYS ILE THR HIS ASN ALA          
SEQRES   6 F  189  THR GLU SER ILE GLU SER SER ALA ASP LYS GLN ILE ILE          
SEQRES   7 F  189  GLU ASN VAL LYS ASP SER LYS ILE SER ILE THR GLU LYS          
SEQRES   8 F  189  GLU ILE LEU LEU ALA THR LYS LYS SER SER ILE MET LEU          
SEQRES   9 F  189  SER GLU ASP LYS ILE VAL ILE LYS ILE GLY ASN SER LEU          
SEQRES  10 F  189  ILE ILE LEU ASP ASP SER ASN ILE SER LEU GLU SER ALA          
SEQRES  11 F  189  THR ILE ASN ILE LYS SER SER ALA ASN ILE ASN ILE GLN          
SEQRES  12 F  189  ALA SER GLN ASN ILE ASP ILE LYS SER LEU ASN ASN SER          
SEQRES  13 F  189  ILE LYS ALA ASP VAL ASN LEU ASN ALA GLU GLY LEU ASP          
SEQRES  14 F  189  VAL ASN ILE LYS GLY SER VAL THR ALA SER ILE LYS GLY          
SEQRES  15 F  189  SER ALA ALA THR MET VAL GLY                                  
HELIX    1 AA1 ASP A  249  LEU A  254  1                                   6    
HELIX    2 AA2 ASP A  328  THR A  335  1                                   8    
HELIX    3 AA3 SER A  347  LYS A  353  1                                   7    
HELIX    4 AA4 ASN A  387  GLN A  398  1                                  12    
HELIX    5 AA5 ASP A  423  ARG A  428  1                                   6    
HELIX    6 AA6 SER A  571  ASN A  581  1                                  11    
HELIX    7 AA7 SER A  621  LEU A  623  5                                   3    
HELIX    8 AA8 ALA A  697  LEU A  701  5                                   5    
HELIX    9 AA9 GLY A  772  ASN A  776  5                                   5    
HELIX   10 AB1 ASP C  249  LEU C  254  1                                   6    
HELIX   11 AB2 ASP C  328  THR C  335  1                                   8    
HELIX   12 AB3 SER C  347  LYS C  353  1                                   7    
HELIX   13 AB4 ASN C  387  GLN C  398  1                                  12    
HELIX   14 AB5 ASP C  423  ARG C  428  1                                   6    
HELIX   15 AB6 SER C  571  ASN C  581  1                                  11    
HELIX   16 AB7 SER C  621  LEU C  623  5                                   3    
HELIX   17 AB8 ALA C  697  LEU C  701  5                                   5    
HELIX   18 AB9 GLY C  772  ASN C  776  5                                   5    
HELIX   19 AC1 ASP E  249  LEU E  254  1                                   6    
HELIX   20 AC2 ASP E  328  THR E  335  1                                   8    
HELIX   21 AC3 SER E  347  LYS E  353  1                                   7    
HELIX   22 AC4 ASN E  387  GLN E  398  1                                  12    
HELIX   23 AC5 ASP E  423  ARG E  428  1                                   6    
HELIX   24 AC6 SER E  571  ASN E  581  1                                  11    
HELIX   25 AC7 SER E  621  LEU E  623  5                                   3    
HELIX   26 AC8 ALA E  697  LEU E  701  5                                   5    
HELIX   27 AC9 GLY E  772  ASN E  776  5                                   5    
SHEET    1 AA1 3 LYS A 179  PRO A 188  0                                        
SHEET    2 AA1 3 ILE A 260  SER A 269 -1  O  ASP A 263   N  ASN A 185           
SHEET    3 AA1 3 LYS A 283  ILE A 291 -1  O  THR A 286   N  ILE A 266           
SHEET    1 AA2 5 ILE A 233  ASN A 234  0                                        
SHEET    2 AA2 5 LYS A 223  GLU A 228 -1  N  CYS A 227   O  ASN A 234           
SHEET    3 AA2 5 TRP A 236  LEU A 241 -1  O  TRP A 236   N  GLU A 225           
SHEET    4 AA2 5 LYS A 320  GLN A 325 -1  O  LYS A 320   N  LEU A 241           
SHEET    5 AA2 5 ILE A 300  HIS A 301 -1  N  HIS A 301   O  LYS A 321           
SHEET    1 AA3 6 ILE A 233  ASN A 234  0                                        
SHEET    2 AA3 6 LYS A 223  GLU A 228 -1  N  CYS A 227   O  ASN A 234           
SHEET    3 AA3 6 LEU A 559  LYS A 569 -1  O  PHE A 568   N  LEU A 224           
SHEET    4 AA3 6 ILE A 613  ASP A 619 -1  O  LYS A 616   N  SER A 562           
SHEET    5 AA3 6 ILE A 523  THR A 526 -1  N  ILE A 523   O  ILE A 617           
SHEET    6 AA3 6 LYS A 451  LEU A 454 -1  N  ILE A 453   O  LEU A 524           
SHEET    1 AA4 2 ILE A 342  LEU A 344  0                                        
SHEET    2 AA4 2 GLN A 378  PHE A 380 -1  O  ALA A 379   N  ALA A 343           
SHEET    1 AA5 2 SER A 363  ASP A 365  0                                        
SHEET    2 AA5 2 SER A 415  HIS A 417  1  O  TYR A 416   N  ASP A 365           
SHEET    1 AA6 2 PHE A 461  TYR A 462  0                                        
SHEET    2 AA6 2 LYS A 490  PRO A 491  1  O  LYS A 490   N  TYR A 462           
SHEET    1 AA7 3 GLU A 480  ASP A 481  0                                        
SHEET    2 AA7 3 LYS A 466  ILE A 468 -1  N  ASN A 467   O  GLU A 480           
SHEET    3 AA7 3 ASN A 499  LEU A 500  1  O  ASN A 499   N  LYS A 466           
SHEET    1 AA8 3 TYR A 637  GLY A 640  0                                        
SHEET    2 AA8 3 ILE A 735  SER A 741 -1  O  ILE A 737   N  ILE A 638           
SHEET    3 AA8 3 LYS A 744  LEU A 750 -1  O  GLU A 746   N  GLU A 738           
SHEET    1 AA9 2 TYR A 692  GLU A 695  0                                        
SHEET    2 AA9 2 ILE A 710  LEU A 713 -1  O  ILE A 711   N  ILE A 694           
SHEET    1 AB1 2 TYR A 781  GLN A 783  0                                        
SHEET    2 AB1 2 GLU A 788  PHE A 790 -1  O  THR A 789   N  THR A 782           
SHEET    1 AB2 2 GLU A 800  SER A 802  0                                        
SHEET    2 AB2 2 ARG A 814  LYS A 816 -1  O  LYS A 816   N  GLU A 800           
SHEET    1 AB3 3 LYS C 179  PRO C 188  0                                        
SHEET    2 AB3 3 ILE C 260  SER C 269 -1  O  ASP C 263   N  ASN C 185           
SHEET    3 AB3 3 LYS C 283  ILE C 291 -1  O  THR C 286   N  ILE C 266           
SHEET    1 AB4 8 ILE C 300  HIS C 301  0                                        
SHEET    2 AB4 8 LYS C 320  GLN C 325 -1  O  LYS C 321   N  HIS C 301           
SHEET    3 AB4 8 ILE C 233  LEU C 241 -1  N  LEU C 241   O  LYS C 320           
SHEET    4 AB4 8 LYS C 223  GLU C 228 -1  N  GLU C 225   O  TRP C 236           
SHEET    5 AB4 8 LEU C 559  LYS C 569 -1  O  PHE C 568   N  LEU C 224           
SHEET    6 AB4 8 ILE C 613  ASP C 619 -1  O  LYS C 616   N  SER C 562           
SHEET    7 AB4 8 ILE C 523  THR C 526 -1  N  ILE C 523   O  ILE C 617           
SHEET    8 AB4 8 LYS C 451  LEU C 454 -1  N  ILE C 453   O  LEU C 524           
SHEET    1 AB5 2 ILE C 342  LEU C 344  0                                        
SHEET    2 AB5 2 GLN C 378  PHE C 380 -1  O  ALA C 379   N  ALA C 343           
SHEET    1 AB6 2 SER C 363  ASP C 365  0                                        
SHEET    2 AB6 2 SER C 415  HIS C 417  1  O  TYR C 416   N  ASP C 365           
SHEET    1 AB7 2 PHE C 461  TYR C 462  0                                        
SHEET    2 AB7 2 LYS C 490  PRO C 491  1  O  LYS C 490   N  TYR C 462           
SHEET    1 AB8 3 GLU C 480  ASP C 481  0                                        
SHEET    2 AB8 3 LYS C 466  ILE C 468 -1  N  ASN C 467   O  GLU C 480           
SHEET    3 AB8 3 ASN C 499  LEU C 500  1  O  ASN C 499   N  LYS C 466           
SHEET    1 AB9 3 TYR C 637  GLY C 640  0                                        
SHEET    2 AB9 3 ILE C 735  SER C 741 -1  O  ILE C 737   N  ILE C 638           
SHEET    3 AB9 3 LYS C 744  LEU C 750 -1  O  GLU C 746   N  GLU C 738           
SHEET    1 AC1 2 TYR C 692  GLU C 695  0                                        
SHEET    2 AC1 2 ILE C 710  LEU C 713 -1  O  ILE C 711   N  ILE C 694           
SHEET    1 AC2 2 TYR C 781  GLN C 783  0                                        
SHEET    2 AC2 2 GLU C 788  PHE C 790 -1  O  THR C 789   N  THR C 782           
SHEET    1 AC3 2 GLU C 800  SER C 802  0                                        
SHEET    2 AC3 2 ARG C 814  LYS C 816 -1  O  LYS C 816   N  GLU C 800           
SHEET    1 AC4 3 LYS E 179  PRO E 188  0                                        
SHEET    2 AC4 3 ILE E 260  SER E 269 -1  O  ASP E 263   N  ASN E 185           
SHEET    3 AC4 3 LYS E 283  ILE E 291 -1  O  THR E 286   N  ILE E 266           
SHEET    1 AC5 8 ILE E 300  HIS E 301  0                                        
SHEET    2 AC5 8 LYS E 320  GLN E 325 -1  O  LYS E 321   N  HIS E 301           
SHEET    3 AC5 8 ILE E 233  LEU E 241 -1  N  LEU E 241   O  LYS E 320           
SHEET    4 AC5 8 LYS E 223  GLU E 228 -1  N  GLU E 225   O  TRP E 236           
SHEET    5 AC5 8 LEU E 559  LYS E 569 -1  O  PHE E 568   N  LEU E 224           
SHEET    6 AC5 8 ILE E 613  ASP E 619 -1  O  LYS E 616   N  SER E 562           
SHEET    7 AC5 8 ILE E 523  THR E 526 -1  N  ILE E 523   O  ILE E 617           
SHEET    8 AC5 8 LYS E 451  LEU E 454 -1  N  ILE E 453   O  LEU E 524           
SHEET    1 AC6 2 ILE E 342  LEU E 344  0                                        
SHEET    2 AC6 2 GLN E 378  PHE E 380 -1  O  ALA E 379   N  ALA E 343           
SHEET    1 AC7 2 SER E 363  ASP E 365  0                                        
SHEET    2 AC7 2 SER E 415  HIS E 417  1  O  TYR E 416   N  ASP E 365           
SHEET    1 AC8 2 PHE E 461  TYR E 462  0                                        
SHEET    2 AC8 2 LYS E 490  PRO E 491  1  O  LYS E 490   N  TYR E 462           
SHEET    1 AC9 3 GLU E 480  ASP E 481  0                                        
SHEET    2 AC9 3 LYS E 466  ILE E 468 -1  N  ASN E 467   O  GLU E 480           
SHEET    3 AC9 3 ASN E 499  LEU E 500  1  O  ASN E 499   N  LYS E 466           
SHEET    1 AD1 3 TYR E 637  GLY E 640  0                                        
SHEET    2 AD1 3 ILE E 735  SER E 741 -1  O  ILE E 737   N  ILE E 638           
SHEET    3 AD1 3 LYS E 744  LEU E 750 -1  O  GLU E 746   N  GLU E 738           
SHEET    1 AD2 2 TYR E 692  GLU E 695  0                                        
SHEET    2 AD2 2 ILE E 710  LEU E 713 -1  O  ILE E 711   N  ILE E 694           
SHEET    1 AD3 2 TYR E 781  GLN E 783  0                                        
SHEET    2 AD3 2 GLU E 788  PHE E 790 -1  O  THR E 789   N  THR E 782           
SHEET    1 AD4 2 GLU E 800  SER E 802  0                                        
SHEET    2 AD4 2 ARG E 814  LYS E 816 -1  O  LYS E 816   N  GLU E 800           
SHEET    1 AD5 3 ASP B   5  HIS B   6  0                                        
SHEET    2 AD5 3 GLY B  14  LYS B  20 -1  O  LYS B  20   N  ASP B   5           
SHEET    3 AD5 3 GLY B  25  GLU B  31 -1  O  THR B  28   N  ILE B  17           
SHEET    1 AD6 5 LYS D  35  ILE D  36  0                                        
SHEET    2 AD6 5 SER B  43  SER B  47  1  N  GLU B  45   O  ILE D  36           
SHEET    3 AD6 5 GLN F  51  ASN F  55  1  O  ILE F  53   N  ILE B  44           
SHEET    4 AD6 5 LYS F  60  ILE F  63 -1  O  ILE F  61   N  GLU F  54           
SHEET    5 AD6 5 ILE F  68  ALA F  71 -1  O  LEU F  69   N  SER F  62           
SHEET    1 AD7 5 ILE B  68  ALA B  71  0                                        
SHEET    2 AD7 5 LYS B  60  ILE B  63 -1  N  SER B  62   O  LEU B  69           
SHEET    3 AD7 5 GLN B  51  ASN B  55 -1  N  GLU B  54   O  ILE B  61           
SHEET    4 AD7 5 SER D  43  SER D  47  1  O  ILE D  44   N  ILE B  53           
SHEET    5 AD7 5 LYS F  35  ILE F  36  1  O  ILE F  36   N  GLU D  45           
SHEET    1 AD8 8 SER B  76  LEU B  79  0                                        
SHEET    2 AD8 8 ILE B  84  LYS B  87 -1  O  LYS B  87   N  SER B  76           
SHEET    3 AD8 8 LEU B  92  LEU B  95 -1  O  LEU B  95   N  ILE B  84           
SHEET    4 AD8 8 ASN B  99  GLU B 103 -1  O  SER B 101   N  ILE B  94           
SHEET    5 AD8 8 THR F 106  ILE F 109  1  O  ASN F 108   N  ILE B 100           
SHEET    6 AD8 8 ILE D 115  ILE D 117  1  N  ASN D 116   O  ILE F 109           
SHEET    7 AD8 8 ILE B 123  ILE B 125  1  N  ASP B 124   O  ILE D 117           
SHEET    8 AD8 8 SER F 131  ILE F 132  1  O  ILE F 132   N  ILE B 123           
SHEET    1 AD9 8 SER B 131  ILE B 132  0                                        
SHEET    2 AD9 8 ILE D 123  ILE D 125  1  O  ILE D 123   N  ILE B 132           
SHEET    3 AD9 8 ILE F 115  ILE F 117  1  O  ILE F 117   N  ASP D 124           
SHEET    4 AD9 8 THR B 106  ILE B 109  1  N  ILE B 107   O  ASN F 116           
SHEET    5 AD9 8 ASN D  99  GLU D 103  1  O  ILE D 100   N  ASN B 108           
SHEET    6 AD9 8 LEU D  92  LEU D  95 -1  N  ILE D  94   O  SER D 101           
SHEET    7 AD9 8 ILE D  84  LYS D  87 -1  N  ILE D  84   O  LEU D  95           
SHEET    8 AD9 8 SER D  76  LEU D  79 -1  N  SER D  76   O  LYS D  87           
SHEET    1 AE1 8 SER D 131  ILE D 132  0                                        
SHEET    2 AE1 8 ILE F 123  ILE F 125  1  O  ILE F 123   N  ILE D 132           
SHEET    3 AE1 8 ILE B 115  ILE B 117  1  N  ILE B 117   O  ASP F 124           
SHEET    4 AE1 8 THR D 106  ILE D 109  1  O  ILE D 109   N  ASN B 116           
SHEET    5 AE1 8 ASN F  99  GLU F 103  1  O  ILE F 100   N  ASN D 108           
SHEET    6 AE1 8 LEU F  92  LEU F  95 -1  N  ILE F  94   O  SER F 101           
SHEET    7 AE1 8 ILE F  84  LYS F  87 -1  N  ILE F  84   O  LEU F  95           
SHEET    8 AE1 8 SER F  76  LEU F  79 -1  N  SER F  76   O  LYS F  87           
SHEET    1 AE2 3 ASP D   5  HIS D   6  0                                        
SHEET    2 AE2 3 GLY D  14  LYS D  20 -1  O  LYS D  20   N  ASP D   5           
SHEET    3 AE2 3 GLY D  25  GLU D  31 -1  O  THR D  28   N  ILE D  17           
SHEET    1 AE3 4 ILE D  68  ALA D  71  0                                        
SHEET    2 AE3 4 LYS D  60  ILE D  63 -1  N  SER D  62   O  LEU D  69           
SHEET    3 AE3 4 GLN D  51  ASN D  55 -1  N  GLU D  54   O  ILE D  61           
SHEET    4 AE3 4 SER F  43  SER F  47  1  O  SER F  46   N  ILE D  53           
SHEET    1 AE4 3 ASP F   5  HIS F   6  0                                        
SHEET    2 AE4 3 GLY F  14  LYS F  20 -1  O  LYS F  20   N  ASP F   5           
SHEET    3 AE4 3 GLY F  25  GLU F  31 -1  O  THR F  28   N  ILE F  17           
CISPEP   1 ASN A  175    VAL A  176          0        13.23                     
CISPEP   2 ALA A  242    TYR A  243          0         3.84                     
CISPEP   3 ILE A  244    ASN A  245          0        -3.73                     
CISPEP   4 LYS A  410    SER A  411          0        -7.14                     
CISPEP   5 ASN A  510    ASP A  511          0        -3.42                     
CISPEP   6 LYS A  678    GLY A  679          0       -19.70                     
CISPEP   7 ASN C  175    VAL C  176          0        13.10                     
CISPEP   8 ALA C  242    TYR C  243          0         3.81                     
CISPEP   9 ILE C  244    ASN C  245          0        -3.77                     
CISPEP  10 LYS C  410    SER C  411          0        -7.13                     
CISPEP  11 ASN C  510    ASP C  511          0        -3.52                     
CISPEP  12 LYS C  678    GLY C  679          0       -19.63                     
CISPEP  13 ASN E  175    VAL E  176          0        13.22                     
CISPEP  14 ALA E  242    TYR E  243          0         3.91                     
CISPEP  15 ILE E  244    ASN E  245          0        -3.71                     
CISPEP  16 LYS E  410    SER E  411          0        -7.11                     
CISPEP  17 ASN E  510    ASP E  511          0        -3.52                     
CISPEP  18 LYS E  678    GLY E  679          0       -19.77                     
CISPEP  19 GLY B   89    ASN B   90          0         4.67                     
CISPEP  20 GLY D   89    ASN D   90          0         4.60                     
CISPEP  21 GLY F   89    ASN F   90          0         4.60                     
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1                      
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      1.000000  0.000000  0.000000        0.00000                         
SCALE2      0.000000  1.000000  0.000000        0.00000                         
SCALE3      0.000000  0.000000  1.000000        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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