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Database: PDB
Entry: 6U9G
LinkDB: 6U9G
Original site: 6U9G 
HEADER    TRANSPORT PROTEIN                       08-SEP-19   6U9G              
TITLE     STRUCTURE OF FRANCISELLA PDPA-VGRG COMPLEX, HALF-LIDDED               
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: PDPA;                                                      
COMPND   3 CHAIN: A, C, E;                                                      
COMPND   4 ENGINEERED: YES;                                                     
COMPND   5 MOL_ID: 2;                                                           
COMPND   6 MOLECULE: VGRG;                                                      
COMPND   7 CHAIN: B, D, F;                                                      
COMPND   8 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: FRANCISELLA TULARENSIS SUBSP. NOVICIDA (STRAIN  
SOURCE   3 U112);                                                               
SOURCE   4 ORGANISM_TAXID: 401614;                                              
SOURCE   5 STRAIN: U112;                                                        
SOURCE   6 GENE: PDPA, FTN_1309;                                                
SOURCE   7 EXPRESSION_SYSTEM: ESCHERICHIA COLI BL21(DE3);                       
SOURCE   8 EXPRESSION_SYSTEM_TAXID: 469008;                                     
SOURCE   9 MOL_ID: 2;                                                           
SOURCE  10 ORGANISM_SCIENTIFIC: FRANCISELLA TULARENSIS SUBSP. NOVICIDA (STRAIN  
SOURCE  11 U112);                                                               
SOURCE  12 ORGANISM_TAXID: 401614;                                              
SOURCE  13 STRAIN: U112;                                                        
SOURCE  14 GENE: FTN_1312;                                                      
SOURCE  15 EXPRESSION_SYSTEM: ESCHERICHIA COLI BL21(DE3);                       
SOURCE  16 EXPRESSION_SYSTEM_TAXID: 469008                                      
KEYWDS    T6SS CENTRAL SPIKE, COMPLEX, TRANSPORT PROTEIN                        
EXPDTA    ELECTRON MICROSCOPY                                                   
AUTHOR    X.YANG,D.L.CLEMENS,B.-Y.LEE,Y.CUI,Z.H.ZHOU,M.A.HORWITZ                
REVDAT   1   23-OCT-19 6U9G    0                                                
JRNL        AUTH   X.YANG,D.L.CLEMENS,B.-Y.LEE,Y.CUI,Z.H.ZHOU,M.A.HORWITZ       
JRNL        TITL   STRUCTURE OF FRANCISELLA PDPA-VGRG COMPLEX, HALF-LIDDED      
JRNL        REF    TO BE PUBLISHED                                              
JRNL        REFN                                                                
REMARK   2                                                                      
REMARK   2 RESOLUTION.    3.98 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   SOFTWARE PACKAGES      : LEGINON                                   
REMARK   3   RECONSTRUCTION SCHEMA  : NULL                                      
REMARK   3                                                                      
REMARK   3 EM MAP-MODEL FITTING AND REFINEMENT                                  
REMARK   3   PDB ENTRY                    : NULL                                
REMARK   3   REFINEMENT SPACE             : REAL                                
REMARK   3   REFINEMENT PROTOCOL          : NULL                                
REMARK   3   REFINEMENT TARGET            : NULL                                
REMARK   3   OVERALL ANISOTROPIC B VALUE  : NULL                                
REMARK   3                                                                      
REMARK   3 FITTING PROCEDURE : NULL                                             
REMARK   3                                                                      
REMARK   3 EM IMAGE RECONSTRUCTION STATISTICS                                   
REMARK   3   NOMINAL PIXEL SIZE (ANGSTROMS)    : NULL                           
REMARK   3   ACTUAL PIXEL SIZE  (ANGSTROMS)    : NULL                           
REMARK   3   EFFECTIVE RESOLUTION (ANGSTROMS)  : 3.980                          
REMARK   3   NUMBER OF PARTICLES               : 10343                          
REMARK   3   CTF CORRECTION METHOD             : PHASE FLIPPING ONLY            
REMARK   3                                                                      
REMARK   3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL                    
REMARK   3                                                                      
REMARK   3 OTHER DETAILS: NULL                                                  
REMARK   4                                                                      
REMARK   4 6U9G COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 09-SEP-19.                  
REMARK 100 THE DEPOSITION ID IS D_1000244230.                                   
REMARK 245                                                                      
REMARK 245 EXPERIMENTAL DETAILS                                                 
REMARK 245   RECONSTRUCTION METHOD          : SINGLE PARTICLE                   
REMARK 245   SPECIMEN TYPE                  : NULL                              
REMARK 245                                                                      
REMARK 245 ELECTRON MICROSCOPE SAMPLE                                           
REMARK 245   SAMPLE TYPE                    : PARTICLE                          
REMARK 245   PARTICLE TYPE                  : POINT                             
REMARK 245   NAME OF SAMPLE                 : PDPA-VGRG COMPLEX                 
REMARK 245   SAMPLE CONCENTRATION (MG ML-1) : NULL                              
REMARK 245   SAMPLE SUPPORT DETAILS         : NULL                              
REMARK 245   SAMPLE VITRIFICATION DETAILS   : NULL                              
REMARK 245   SAMPLE BUFFER                  : NULL                              
REMARK 245   PH                             : 7.50                              
REMARK 245   SAMPLE DETAILS                 : NULL                              
REMARK 245                                                                      
REMARK 245 DATA ACQUISITION                                                     
REMARK 245   DATE OF EXPERIMENT                : NULL                           
REMARK 245   NUMBER OF MICROGRAPHS-IMAGES      : NULL                           
REMARK 245   TEMPERATURE (KELVIN)              : NULL                           
REMARK 245   MICROSCOPE MODEL                  : FEI TITAN KRIOS                
REMARK 245   DETECTOR TYPE                     : GATAN K2 SUMMIT (4K X 4K)      
REMARK 245   MINIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MAXIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MINIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   MAXIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   NOMINAL CS                        : NULL                           
REMARK 245   IMAGING MODE                      : BRIGHT FIELD                   
REMARK 245   ELECTRON DOSE (ELECTRONS NM**-2)  : 47.00                          
REMARK 245   ILLUMINATION MODE                 : FLOOD BEAM                     
REMARK 245   NOMINAL MAGNIFICATION             : NULL                           
REMARK 245   CALIBRATED MAGNIFICATION          : NULL                           
REMARK 245   SOURCE                            : FIELD EMISSION GUN             
REMARK 245   ACCELERATION VOLTAGE (KV)         : 300                            
REMARK 245   IMAGING DETAILS                   : NULL                           
REMARK 247                                                                      
REMARK 247 ELECTRON MICROSCOPY                                                  
REMARK 247  THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON          
REMARK 247  MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE              
REMARK 247  THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES           
REMARK 247  ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION         
REMARK 247  OF THE STRUCTURE FACTORS.                                           
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: HEXAMERIC                         
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, C, E, B, D, F                      
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     MET A     1                                                      
REMARK 465     ILE A     2                                                      
REMARK 465     ALA A     3                                                      
REMARK 465     VAL A     4                                                      
REMARK 465     LYS A     5                                                      
REMARK 465     ASP A     6                                                      
REMARK 465     ILE A     7                                                      
REMARK 465     THR A     8                                                      
REMARK 465     ASP A     9                                                      
REMARK 465     LEU A    10                                                      
REMARK 465     ASN A    11                                                      
REMARK 465     ILE A    12                                                      
REMARK 465     GLN A    13                                                      
REMARK 465     ASP A    14                                                      
REMARK 465     ILE A    15                                                      
REMARK 465     ILE A    16                                                      
REMARK 465     SER A    17                                                      
REMARK 465     GLN A    18                                                      
REMARK 465     LEU A    19                                                      
REMARK 465     THR A    20                                                      
REMARK 465     SER A    21                                                      
REMARK 465     GLU A    22                                                      
REMARK 465     VAL A    23                                                      
REMARK 465     ILE A    24                                                      
REMARK 465     ASN A    25                                                      
REMARK 465     GLY A    26                                                      
REMARK 465     ASP A    27                                                      
REMARK 465     THR A    28                                                      
REMARK 465     THR A    29                                                      
REMARK 465     PRO A    30                                                      
REMARK 465     SER A    31                                                      
REMARK 465     SER A    32                                                      
REMARK 465     ALA A    33                                                      
REMARK 465     LYS A    34                                                      
REMARK 465     PHE A    35                                                      
REMARK 465     ALA A    36                                                      
REMARK 465     CYS A    37                                                      
REMARK 465     GLU A    38                                                      
REMARK 465     ILE A    39                                                      
REMARK 465     ASN A    40                                                      
REMARK 465     SER A    41                                                      
REMARK 465     TYR A    42                                                      
REMARK 465     ILE A    43                                                      
REMARK 465     ILE A    44                                                      
REMARK 465     ASN A    45                                                      
REMARK 465     TYR A    46                                                      
REMARK 465     ASN A    47                                                      
REMARK 465     LEU A    48                                                      
REMARK 465     SER A    49                                                      
REMARK 465     ASN A    50                                                      
REMARK 465     ILE A    51                                                      
REMARK 465     ASN A    52                                                      
REMARK 465     LEU A    53                                                      
REMARK 465     ILE A    54                                                      
REMARK 465     ASN A    55                                                      
REMARK 465     THR A    56                                                      
REMARK 465     GLN A    57                                                      
REMARK 465     LEU A    58                                                      
REMARK 465     LYS A    59                                                      
REMARK 465     ASN A    60                                                      
REMARK 465     THR A    61                                                      
REMARK 465     LYS A    62                                                      
REMARK 465     ILE A    63                                                      
REMARK 465     LEU A    64                                                      
REMARK 465     TYR A    65                                                      
REMARK 465     ARG A    66                                                      
REMARK 465     LYS A    67                                                      
REMARK 465     GLY A    68                                                      
REMARK 465     LEU A    69                                                      
REMARK 465     ILE A    70                                                      
REMARK 465     SER A    71                                                      
REMARK 465     LYS A    72                                                      
REMARK 465     LEU A    73                                                      
REMARK 465     ASP A    74                                                      
REMARK 465     TYR A    75                                                      
REMARK 465     GLU A    76                                                      
REMARK 465     LYS A    77                                                      
REMARK 465     LEU A    96                                                      
REMARK 465     TYR A    97                                                      
REMARK 465     PHE A    98                                                      
REMARK 465     SER A    99                                                      
REMARK 465     THR A   100                                                      
REMARK 465     ASN A   101                                                      
REMARK 465     TYR A   102                                                      
REMARK 465     LYS A   103                                                      
REMARK 465     ASP A   104                                                      
REMARK 465     LEU A   125                                                      
REMARK 465     GLU A   126                                                      
REMARK 465     LEU A   127                                                      
REMARK 465     PRO A   128                                                      
REMARK 465     GLN A   147                                                      
REMARK 465     ARG A   148                                                      
REMARK 465     SER A   149                                                      
REMARK 465     SER A   150                                                      
REMARK 465     ASP A   151                                                      
REMARK 465     LEU A   152                                                      
REMARK 465     ASN A   153                                                      
REMARK 465     LYS A   154                                                      
REMARK 465     THR A   155                                                      
REMARK 465     ILE A   156                                                      
REMARK 465     ILE A   157                                                      
REMARK 465     LYS A   158                                                      
REMARK 465     SER A   199                                                      
REMARK 465     PHE A   200                                                      
REMARK 465     VAL A   201                                                      
REMARK 465     SER A   202                                                      
REMARK 465     THR A   203                                                      
REMARK 465     ARG A   204                                                      
REMARK 465     ASN A   205                                                      
REMARK 465     LYS A   206                                                      
REMARK 465     GLN A   207                                                      
REMARK 465     TYR A   208                                                      
REMARK 465     PHE A   209                                                      
REMARK 465     LYS A   210                                                      
REMARK 465     ASN A   271                                                      
REMARK 465     PHE A   272                                                      
REMARK 465     TYR A   273                                                      
REMARK 465     LYS A   274                                                      
REMARK 465     LYS A   275                                                      
REMARK 465     GLU A   276                                                      
REMARK 465     SER A   277                                                      
REMARK 465     LYS A   278                                                      
REMARK 465     LYS A   279                                                      
REMARK 465     ASP A   280                                                      
REMARK 465     PHE A   304                                                      
REMARK 465     GLU A   305                                                      
REMARK 465     TYR A   306                                                      
REMARK 465     SER A   307                                                      
REMARK 465     ILE A   308                                                      
REMARK 465     TYR A   309                                                      
REMARK 465     SER A   310                                                      
REMARK 465     TYR A   311                                                      
REMARK 465     THR A   312                                                      
REMARK 465     LYS A   313                                                      
REMARK 465     ASN A   314                                                      
REMARK 465     VAL A   315                                                      
REMARK 465     SER A   316                                                      
REMARK 465     SER A   317                                                      
REMARK 465     LEU A   582                                                      
REMARK 465     HIS A   583                                                      
REMARK 465     ASN A   584                                                      
REMARK 465     PHE A   585                                                      
REMARK 465     HIS A   586                                                      
REMARK 465     TYR A   587                                                      
REMARK 465     LYS A   588                                                      
REMARK 465     SER A   589                                                      
REMARK 465     ASP A   590                                                      
REMARK 465     SER A   591                                                      
REMARK 465     GLU A   592                                                      
REMARK 465     SER A   593                                                      
REMARK 465     ASP A   594                                                      
REMARK 465     VAL A   595                                                      
REMARK 465     TYR A   596                                                      
REMARK 465     GLU A   597                                                      
REMARK 465     LYS A   598                                                      
REMARK 465     ILE A   599                                                      
REMARK 465     ALA A   600                                                      
REMARK 465     PHE A   601                                                      
REMARK 465     THR A   602                                                      
REMARK 465     LYS A   603                                                      
REMARK 465     TYR A   604                                                      
REMARK 465     PRO A   605                                                      
REMARK 465     SER A   606                                                      
REMARK 465     LEU A   607                                                      
REMARK 465     THR A   608                                                      
REMARK 465     LYS A   818                                                      
REMARK 465     GLY A   819                                                      
REMARK 465     ASN A   820                                                      
REMARK 465     MET C     1                                                      
REMARK 465     ILE C     2                                                      
REMARK 465     ALA C     3                                                      
REMARK 465     VAL C     4                                                      
REMARK 465     LYS C     5                                                      
REMARK 465     ASP C     6                                                      
REMARK 465     ILE C     7                                                      
REMARK 465     THR C     8                                                      
REMARK 465     ASP C     9                                                      
REMARK 465     LEU C    10                                                      
REMARK 465     ASN C    11                                                      
REMARK 465     ILE C    12                                                      
REMARK 465     GLN C    13                                                      
REMARK 465     ASP C    14                                                      
REMARK 465     ILE C    15                                                      
REMARK 465     ILE C    16                                                      
REMARK 465     SER C    17                                                      
REMARK 465     GLN C    18                                                      
REMARK 465     LEU C    19                                                      
REMARK 465     THR C    20                                                      
REMARK 465     SER C    21                                                      
REMARK 465     GLU C    22                                                      
REMARK 465     VAL C    23                                                      
REMARK 465     ILE C    24                                                      
REMARK 465     ASN C    25                                                      
REMARK 465     GLY C    26                                                      
REMARK 465     ASP C    27                                                      
REMARK 465     THR C    28                                                      
REMARK 465     THR C    29                                                      
REMARK 465     PRO C    30                                                      
REMARK 465     SER C    31                                                      
REMARK 465     SER C    32                                                      
REMARK 465     ALA C    33                                                      
REMARK 465     LYS C    34                                                      
REMARK 465     PHE C    35                                                      
REMARK 465     ALA C    36                                                      
REMARK 465     CYS C    37                                                      
REMARK 465     GLU C    38                                                      
REMARK 465     ILE C    39                                                      
REMARK 465     ASN C    40                                                      
REMARK 465     SER C    41                                                      
REMARK 465     TYR C    42                                                      
REMARK 465     ILE C    43                                                      
REMARK 465     ILE C    44                                                      
REMARK 465     ASN C    45                                                      
REMARK 465     TYR C    46                                                      
REMARK 465     ASN C    47                                                      
REMARK 465     LEU C    48                                                      
REMARK 465     SER C    49                                                      
REMARK 465     ASN C    50                                                      
REMARK 465     ILE C    51                                                      
REMARK 465     ASN C    52                                                      
REMARK 465     LEU C    53                                                      
REMARK 465     ILE C    54                                                      
REMARK 465     ASN C    55                                                      
REMARK 465     THR C    56                                                      
REMARK 465     GLN C    57                                                      
REMARK 465     LEU C    58                                                      
REMARK 465     LYS C    59                                                      
REMARK 465     ASN C    60                                                      
REMARK 465     THR C    61                                                      
REMARK 465     LYS C    62                                                      
REMARK 465     ILE C    63                                                      
REMARK 465     LEU C    64                                                      
REMARK 465     TYR C    65                                                      
REMARK 465     ARG C    66                                                      
REMARK 465     LYS C    67                                                      
REMARK 465     GLY C    68                                                      
REMARK 465     LEU C    69                                                      
REMARK 465     ILE C    70                                                      
REMARK 465     SER C    71                                                      
REMARK 465     LYS C    72                                                      
REMARK 465     LEU C    73                                                      
REMARK 465     ASP C    74                                                      
REMARK 465     TYR C    75                                                      
REMARK 465     GLU C    76                                                      
REMARK 465     LYS C    77                                                      
REMARK 465     LEU C    96                                                      
REMARK 465     TYR C    97                                                      
REMARK 465     PHE C    98                                                      
REMARK 465     SER C    99                                                      
REMARK 465     THR C   100                                                      
REMARK 465     ASN C   101                                                      
REMARK 465     TYR C   102                                                      
REMARK 465     LYS C   103                                                      
REMARK 465     ASP C   104                                                      
REMARK 465     LEU C   125                                                      
REMARK 465     GLU C   126                                                      
REMARK 465     LEU C   127                                                      
REMARK 465     PRO C   128                                                      
REMARK 465     GLN C   147                                                      
REMARK 465     ARG C   148                                                      
REMARK 465     SER C   149                                                      
REMARK 465     SER C   150                                                      
REMARK 465     ASP C   151                                                      
REMARK 465     LEU C   152                                                      
REMARK 465     ASN C   153                                                      
REMARK 465     LYS C   154                                                      
REMARK 465     THR C   155                                                      
REMARK 465     ILE C   156                                                      
REMARK 465     ILE C   157                                                      
REMARK 465     LYS C   158                                                      
REMARK 465     SER C   199                                                      
REMARK 465     PHE C   200                                                      
REMARK 465     VAL C   201                                                      
REMARK 465     SER C   202                                                      
REMARK 465     THR C   203                                                      
REMARK 465     ARG C   204                                                      
REMARK 465     ASN C   205                                                      
REMARK 465     LYS C   206                                                      
REMARK 465     GLN C   207                                                      
REMARK 465     TYR C   208                                                      
REMARK 465     PHE C   209                                                      
REMARK 465     LYS C   210                                                      
REMARK 465     ASN C   271                                                      
REMARK 465     PHE C   272                                                      
REMARK 465     TYR C   273                                                      
REMARK 465     LYS C   274                                                      
REMARK 465     LYS C   275                                                      
REMARK 465     GLU C   276                                                      
REMARK 465     SER C   277                                                      
REMARK 465     LYS C   278                                                      
REMARK 465     LYS C   279                                                      
REMARK 465     ASP C   280                                                      
REMARK 465     PHE C   304                                                      
REMARK 465     GLU C   305                                                      
REMARK 465     TYR C   306                                                      
REMARK 465     SER C   307                                                      
REMARK 465     ILE C   308                                                      
REMARK 465     TYR C   309                                                      
REMARK 465     SER C   310                                                      
REMARK 465     TYR C   311                                                      
REMARK 465     THR C   312                                                      
REMARK 465     LYS C   313                                                      
REMARK 465     ASN C   314                                                      
REMARK 465     VAL C   315                                                      
REMARK 465     SER C   316                                                      
REMARK 465     SER C   317                                                      
REMARK 465     LEU C   582                                                      
REMARK 465     HIS C   583                                                      
REMARK 465     ASN C   584                                                      
REMARK 465     PHE C   585                                                      
REMARK 465     HIS C   586                                                      
REMARK 465     TYR C   587                                                      
REMARK 465     LYS C   588                                                      
REMARK 465     SER C   589                                                      
REMARK 465     ASP C   590                                                      
REMARK 465     SER C   591                                                      
REMARK 465     GLU C   592                                                      
REMARK 465     SER C   593                                                      
REMARK 465     ASP C   594                                                      
REMARK 465     VAL C   595                                                      
REMARK 465     TYR C   596                                                      
REMARK 465     GLU C   597                                                      
REMARK 465     LYS C   598                                                      
REMARK 465     ILE C   599                                                      
REMARK 465     ALA C   600                                                      
REMARK 465     PHE C   601                                                      
REMARK 465     THR C   602                                                      
REMARK 465     LYS C   603                                                      
REMARK 465     TYR C   604                                                      
REMARK 465     PRO C   605                                                      
REMARK 465     SER C   606                                                      
REMARK 465     LEU C   607                                                      
REMARK 465     THR C   608                                                      
REMARK 465     LYS C   818                                                      
REMARK 465     GLY C   819                                                      
REMARK 465     ASN C   820                                                      
REMARK 465     MET E     1                                                      
REMARK 465     ILE E     2                                                      
REMARK 465     ALA E     3                                                      
REMARK 465     VAL E     4                                                      
REMARK 465     LYS E     5                                                      
REMARK 465     ASP E     6                                                      
REMARK 465     ILE E     7                                                      
REMARK 465     THR E     8                                                      
REMARK 465     ASP E     9                                                      
REMARK 465     LEU E    10                                                      
REMARK 465     ASN E    11                                                      
REMARK 465     ILE E    12                                                      
REMARK 465     GLN E    13                                                      
REMARK 465     ASP E    14                                                      
REMARK 465     ILE E    15                                                      
REMARK 465     ILE E    16                                                      
REMARK 465     SER E    17                                                      
REMARK 465     GLN E    18                                                      
REMARK 465     LEU E    19                                                      
REMARK 465     THR E    20                                                      
REMARK 465     SER E    21                                                      
REMARK 465     GLU E    22                                                      
REMARK 465     VAL E    23                                                      
REMARK 465     ILE E    24                                                      
REMARK 465     ASN E    25                                                      
REMARK 465     GLY E    26                                                      
REMARK 465     ASP E    27                                                      
REMARK 465     THR E    28                                                      
REMARK 465     THR E    29                                                      
REMARK 465     PRO E    30                                                      
REMARK 465     SER E    31                                                      
REMARK 465     SER E    32                                                      
REMARK 465     ALA E    33                                                      
REMARK 465     LYS E    34                                                      
REMARK 465     PHE E    35                                                      
REMARK 465     ALA E    36                                                      
REMARK 465     CYS E    37                                                      
REMARK 465     GLU E    38                                                      
REMARK 465     ILE E    39                                                      
REMARK 465     ASN E    40                                                      
REMARK 465     SER E    41                                                      
REMARK 465     TYR E    42                                                      
REMARK 465     ILE E    43                                                      
REMARK 465     ILE E    44                                                      
REMARK 465     ASN E    45                                                      
REMARK 465     TYR E    46                                                      
REMARK 465     ASN E    47                                                      
REMARK 465     LEU E    48                                                      
REMARK 465     SER E    49                                                      
REMARK 465     ASN E    50                                                      
REMARK 465     ILE E    51                                                      
REMARK 465     ASN E    52                                                      
REMARK 465     LEU E    53                                                      
REMARK 465     ILE E    54                                                      
REMARK 465     ASN E    55                                                      
REMARK 465     THR E    56                                                      
REMARK 465     GLN E    57                                                      
REMARK 465     LEU E    58                                                      
REMARK 465     LYS E    59                                                      
REMARK 465     ASN E    60                                                      
REMARK 465     THR E    61                                                      
REMARK 465     LYS E    62                                                      
REMARK 465     ILE E    63                                                      
REMARK 465     LEU E    64                                                      
REMARK 465     TYR E    65                                                      
REMARK 465     ARG E    66                                                      
REMARK 465     LYS E    67                                                      
REMARK 465     GLY E    68                                                      
REMARK 465     LEU E    69                                                      
REMARK 465     ILE E    70                                                      
REMARK 465     SER E    71                                                      
REMARK 465     LYS E    72                                                      
REMARK 465     LEU E    73                                                      
REMARK 465     ASP E    74                                                      
REMARK 465     TYR E    75                                                      
REMARK 465     GLU E    76                                                      
REMARK 465     LYS E    77                                                      
REMARK 465     LEU E    96                                                      
REMARK 465     TYR E    97                                                      
REMARK 465     PHE E    98                                                      
REMARK 465     SER E    99                                                      
REMARK 465     THR E   100                                                      
REMARK 465     ASN E   101                                                      
REMARK 465     TYR E   102                                                      
REMARK 465     LYS E   103                                                      
REMARK 465     ASP E   104                                                      
REMARK 465     LEU E   125                                                      
REMARK 465     GLU E   126                                                      
REMARK 465     LEU E   127                                                      
REMARK 465     PRO E   128                                                      
REMARK 465     GLN E   147                                                      
REMARK 465     ARG E   148                                                      
REMARK 465     SER E   149                                                      
REMARK 465     SER E   150                                                      
REMARK 465     ASP E   151                                                      
REMARK 465     LEU E   152                                                      
REMARK 465     ASN E   153                                                      
REMARK 465     LYS E   154                                                      
REMARK 465     THR E   155                                                      
REMARK 465     ILE E   156                                                      
REMARK 465     ILE E   157                                                      
REMARK 465     LYS E   158                                                      
REMARK 465     SER E   199                                                      
REMARK 465     PHE E   200                                                      
REMARK 465     VAL E   201                                                      
REMARK 465     SER E   202                                                      
REMARK 465     THR E   203                                                      
REMARK 465     ARG E   204                                                      
REMARK 465     ASN E   205                                                      
REMARK 465     LYS E   206                                                      
REMARK 465     GLN E   207                                                      
REMARK 465     TYR E   208                                                      
REMARK 465     PHE E   209                                                      
REMARK 465     LYS E   210                                                      
REMARK 465     ASN E   271                                                      
REMARK 465     PHE E   272                                                      
REMARK 465     TYR E   273                                                      
REMARK 465     LYS E   274                                                      
REMARK 465     LYS E   275                                                      
REMARK 465     GLU E   276                                                      
REMARK 465     SER E   277                                                      
REMARK 465     LYS E   278                                                      
REMARK 465     LYS E   279                                                      
REMARK 465     ASP E   280                                                      
REMARK 465     PHE E   304                                                      
REMARK 465     GLU E   305                                                      
REMARK 465     TYR E   306                                                      
REMARK 465     SER E   307                                                      
REMARK 465     ILE E   308                                                      
REMARK 465     TYR E   309                                                      
REMARK 465     SER E   310                                                      
REMARK 465     TYR E   311                                                      
REMARK 465     THR E   312                                                      
REMARK 465     LYS E   313                                                      
REMARK 465     ASN E   314                                                      
REMARK 465     VAL E   315                                                      
REMARK 465     SER E   316                                                      
REMARK 465     SER E   317                                                      
REMARK 465     LEU E   582                                                      
REMARK 465     HIS E   583                                                      
REMARK 465     ASN E   584                                                      
REMARK 465     PHE E   585                                                      
REMARK 465     HIS E   586                                                      
REMARK 465     TYR E   587                                                      
REMARK 465     LYS E   588                                                      
REMARK 465     SER E   589                                                      
REMARK 465     ASP E   590                                                      
REMARK 465     SER E   591                                                      
REMARK 465     GLU E   592                                                      
REMARK 465     SER E   593                                                      
REMARK 465     ASP E   594                                                      
REMARK 465     VAL E   595                                                      
REMARK 465     TYR E   596                                                      
REMARK 465     GLU E   597                                                      
REMARK 465     LYS E   598                                                      
REMARK 465     ILE E   599                                                      
REMARK 465     ALA E   600                                                      
REMARK 465     PHE E   601                                                      
REMARK 465     THR E   602                                                      
REMARK 465     LYS E   603                                                      
REMARK 465     TYR E   604                                                      
REMARK 465     PRO E   605                                                      
REMARK 465     SER E   606                                                      
REMARK 465     LEU E   607                                                      
REMARK 465     THR E   608                                                      
REMARK 465     LYS E   818                                                      
REMARK 465     GLY E   819                                                      
REMARK 465     ASN E   820                                                      
REMARK 465     MET B   -24                                                      
REMARK 465     ASP B   -23                                                      
REMARK 465     TYR B   -22                                                      
REMARK 465     LYS B   -21                                                      
REMARK 465     ASP B   -20                                                      
REMARK 465     ASP B   -19                                                      
REMARK 465     ASP B   -18                                                      
REMARK 465     ASP B   -17                                                      
REMARK 465     LYS B   -16                                                      
REMARK 465     ASP B   -15                                                      
REMARK 465     TYR B   -14                                                      
REMARK 465     LYS B   -13                                                      
REMARK 465     ASP B   -12                                                      
REMARK 465     ASP B   -11                                                      
REMARK 465     ASP B   -10                                                      
REMARK 465     ASP B    -9                                                      
REMARK 465     LYS B    -8                                                      
REMARK 465     ASP B    -7                                                      
REMARK 465     TYR B    -6                                                      
REMARK 465     LYS B    -5                                                      
REMARK 465     ASP B    -4                                                      
REMARK 465     ASP B    -3                                                      
REMARK 465     ASP B    -2                                                      
REMARK 465     ASP B    -1                                                      
REMARK 465     LYS B     0                                                      
REMARK 465     GLY B     1                                                      
REMARK 465     SER B     2                                                      
REMARK 465     VAL B   136                                                      
REMARK 465     ASN B   137                                                      
REMARK 465     LEU B   138                                                      
REMARK 465     ASN B   139                                                      
REMARK 465     ALA B   140                                                      
REMARK 465     GLU B   141                                                      
REMARK 465     GLY B   142                                                      
REMARK 465     LEU B   143                                                      
REMARK 465     ASP B   144                                                      
REMARK 465     VAL B   145                                                      
REMARK 465     ASN B   146                                                      
REMARK 465     ILE B   147                                                      
REMARK 465     LYS B   148                                                      
REMARK 465     GLY B   149                                                      
REMARK 465     SER B   150                                                      
REMARK 465     VAL B   151                                                      
REMARK 465     THR B   152                                                      
REMARK 465     ALA B   153                                                      
REMARK 465     SER B   154                                                      
REMARK 465     ILE B   155                                                      
REMARK 465     LYS B   156                                                      
REMARK 465     GLY B   157                                                      
REMARK 465     SER B   158                                                      
REMARK 465     ALA B   159                                                      
REMARK 465     ALA B   160                                                      
REMARK 465     THR B   161                                                      
REMARK 465     MET B   162                                                      
REMARK 465     VAL B   163                                                      
REMARK 465     GLY B   164                                                      
REMARK 465     MET D   -24                                                      
REMARK 465     ASP D   -23                                                      
REMARK 465     TYR D   -22                                                      
REMARK 465     LYS D   -21                                                      
REMARK 465     ASP D   -20                                                      
REMARK 465     ASP D   -19                                                      
REMARK 465     ASP D   -18                                                      
REMARK 465     ASP D   -17                                                      
REMARK 465     LYS D   -16                                                      
REMARK 465     ASP D   -15                                                      
REMARK 465     TYR D   -14                                                      
REMARK 465     LYS D   -13                                                      
REMARK 465     ASP D   -12                                                      
REMARK 465     ASP D   -11                                                      
REMARK 465     ASP D   -10                                                      
REMARK 465     ASP D    -9                                                      
REMARK 465     LYS D    -8                                                      
REMARK 465     ASP D    -7                                                      
REMARK 465     TYR D    -6                                                      
REMARK 465     LYS D    -5                                                      
REMARK 465     ASP D    -4                                                      
REMARK 465     ASP D    -3                                                      
REMARK 465     ASP D    -2                                                      
REMARK 465     ASP D    -1                                                      
REMARK 465     LYS D     0                                                      
REMARK 465     GLY D     1                                                      
REMARK 465     SER D     2                                                      
REMARK 465     VAL D   136                                                      
REMARK 465     ASN D   137                                                      
REMARK 465     LEU D   138                                                      
REMARK 465     ASN D   139                                                      
REMARK 465     ALA D   140                                                      
REMARK 465     GLU D   141                                                      
REMARK 465     GLY D   142                                                      
REMARK 465     LEU D   143                                                      
REMARK 465     ASP D   144                                                      
REMARK 465     VAL D   145                                                      
REMARK 465     ASN D   146                                                      
REMARK 465     ILE D   147                                                      
REMARK 465     LYS D   148                                                      
REMARK 465     GLY D   149                                                      
REMARK 465     SER D   150                                                      
REMARK 465     VAL D   151                                                      
REMARK 465     THR D   152                                                      
REMARK 465     ALA D   153                                                      
REMARK 465     SER D   154                                                      
REMARK 465     ILE D   155                                                      
REMARK 465     LYS D   156                                                      
REMARK 465     GLY D   157                                                      
REMARK 465     SER D   158                                                      
REMARK 465     ALA D   159                                                      
REMARK 465     ALA D   160                                                      
REMARK 465     THR D   161                                                      
REMARK 465     MET D   162                                                      
REMARK 465     VAL D   163                                                      
REMARK 465     GLY D   164                                                      
REMARK 465     MET F   -24                                                      
REMARK 465     ASP F   -23                                                      
REMARK 465     TYR F   -22                                                      
REMARK 465     LYS F   -21                                                      
REMARK 465     ASP F   -20                                                      
REMARK 465     ASP F   -19                                                      
REMARK 465     ASP F   -18                                                      
REMARK 465     ASP F   -17                                                      
REMARK 465     LYS F   -16                                                      
REMARK 465     ASP F   -15                                                      
REMARK 465     TYR F   -14                                                      
REMARK 465     LYS F   -13                                                      
REMARK 465     ASP F   -12                                                      
REMARK 465     ASP F   -11                                                      
REMARK 465     ASP F   -10                                                      
REMARK 465     ASP F    -9                                                      
REMARK 465     LYS F    -8                                                      
REMARK 465     ASP F    -7                                                      
REMARK 465     TYR F    -6                                                      
REMARK 465     LYS F    -5                                                      
REMARK 465     ASP F    -4                                                      
REMARK 465     ASP F    -3                                                      
REMARK 465     ASP F    -2                                                      
REMARK 465     ASP F    -1                                                      
REMARK 465     LYS F     0                                                      
REMARK 465     GLY F     1                                                      
REMARK 465     SER F     2                                                      
REMARK 465     VAL F   136                                                      
REMARK 465     ASN F   137                                                      
REMARK 465     LEU F   138                                                      
REMARK 465     ASN F   139                                                      
REMARK 465     ALA F   140                                                      
REMARK 465     GLU F   141                                                      
REMARK 465     GLY F   142                                                      
REMARK 465     LEU F   143                                                      
REMARK 465     ASP F   144                                                      
REMARK 465     VAL F   145                                                      
REMARK 465     ASN F   146                                                      
REMARK 465     ILE F   147                                                      
REMARK 465     LYS F   148                                                      
REMARK 465     GLY F   149                                                      
REMARK 465     SER F   150                                                      
REMARK 465     VAL F   151                                                      
REMARK 465     THR F   152                                                      
REMARK 465     ALA F   153                                                      
REMARK 465     SER F   154                                                      
REMARK 465     ILE F   155                                                      
REMARK 465     LYS F   156                                                      
REMARK 465     GLY F   157                                                      
REMARK 465     SER F   158                                                      
REMARK 465     ALA F   159                                                      
REMARK 465     ALA F   160                                                      
REMARK 465     THR F   161                                                      
REMARK 465     MET F   162                                                      
REMARK 465     VAL F   163                                                      
REMARK 465     GLY F   164                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     TYR A  78    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     LYS A  79    CG   CD   CE   NZ                                   
REMARK 470     ARG A  80    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     TYR A  81    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     CYS A  82    SG                                                  
REMARK 470     ILE A  83    CG1  CG2  CD1                                       
REMARK 470     ILE A  84    CG1  CG2  CD1                                       
REMARK 470     SER A  85    OG                                                  
REMARK 470     ARG A  86    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     PHE A  87    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     LYS A  88    CG   CD   CE   NZ                                   
REMARK 470     ASN A  89    CG   OD1  ND2                                       
REMARK 470     ASN A  90    CG   OD1  ND2                                       
REMARK 470     ILE A  91    CG1  CG2  CD1                                       
REMARK 470     ASP A  92    CG   OD1  OD2                                       
REMARK 470     GLU A  93    CG   CD   OE1  OE2                                  
REMARK 470     PHE A  94    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ILE A  95    CG1  CG2  CD1                                       
REMARK 470     SER A 105    OG                                                  
REMARK 470     GLN A 106    CG   CD   OE1  NE2                                  
REMARK 470     SER A 107    OG                                                  
REMARK 470     LEU A 108    CG   CD1  CD2                                       
REMARK 470     LYS A 109    CG   CD   CE   NZ                                   
REMARK 470     ILE A 110    CG1  CG2  CD1                                       
REMARK 470     ILE A 112    CG1  CG2  CD1                                       
REMARK 470     LYS A 113    CG   CD   CE   NZ                                   
REMARK 470     GLU A 114    CG   CD   OE1  OE2                                  
REMARK 470     LEU A 115    CG   CD1  CD2                                       
REMARK 470     GLN A 116    CG   CD   OE1  NE2                                  
REMARK 470     ASN A 117    CG   OD1  ND2                                       
REMARK 470     SER A 118    OG                                                  
REMARK 470     CYS A 119    SG                                                  
REMARK 470     SER A 120    OG                                                  
REMARK 470     SER A 121    OG                                                  
REMARK 470     SER A 122    OG                                                  
REMARK 470     LEU A 123    CG   CD1  CD2                                       
REMARK 470     ILE A 124    CG1  CG2  CD1                                       
REMARK 470     HIS A 129    CG   ND1  CD2  CE1  NE2                             
REMARK 470     ASP A 130    CG   OD1  OD2                                       
REMARK 470     TYR A 131    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     ILE A 132    CG1  CG2  CD1                                       
REMARK 470     ARG A 133    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS A 134    CG   CD   CE   NZ                                   
REMARK 470     ILE A 135    CG1  CG2  CD1                                       
REMARK 470     ASP A 136    CG   OD1  OD2                                       
REMARK 470     VAL A 137    CG1  CG2                                            
REMARK 470     LEU A 138    CG   CD1  CD2                                       
REMARK 470     LEU A 139    CG   CD1  CD2                                       
REMARK 470     THR A 140    OG1  CG2                                            
REMARK 470     SER A 141    OG                                                  
REMARK 470     ILE A 142    CG1  CG2  CD1                                       
REMARK 470     ASP A 143    CG   OD1  OD2                                       
REMARK 470     SER A 144    OG                                                  
REMARK 470     ILE A 146    CG1  CG2  CD1                                       
REMARK 470     GLN A 159    CG   CD   OE1  NE2                                  
REMARK 470     LEU A 160    CG   CD1  CD2                                       
REMARK 470     ASN A 161    CG   OD1  ND2                                       
REMARK 470     LYS A 162    CG   CD   CE   NZ                                   
REMARK 470     LEU A 163    CG   CD1  CD2                                       
REMARK 470     ARG A 164    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     SER A 165    OG                                                  
REMARK 470     SER A 166    OG                                                  
REMARK 470     LEU A 167    CG   CD1  CD2                                       
REMARK 470     SER A 168    OG                                                  
REMARK 470     ARG A 169    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     TYR A 170    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     TYR A 173    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     ASN A 174    CG   OD1  ND2                                       
REMARK 470     ASN A 175    CG   OD1  ND2                                       
REMARK 470     ILE A 198    CG1  CG2  CD1                                       
REMARK 470     TYR A 243    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     ILE A 244    CG1  CG2  CD1                                       
REMARK 470     HIS A 281    CG   ND1  CD2  CE1  NE2                             
REMARK 470     ASN A 510    CG   OD1  ND2                                       
REMARK 470     ASP A 511    CG   OD1  OD2                                       
REMARK 470     ASP A 512    CG   OD1  OD2                                       
REMARK 470     LYS A 513    CG   CD   CE   NZ                                   
REMARK 470     HIS A 609    CG   ND1  CD2  CE1  NE2                             
REMARK 470     TYR C  78    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     LYS C  79    CG   CD   CE   NZ                                   
REMARK 470     ARG C  80    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     TYR C  81    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     CYS C  82    SG                                                  
REMARK 470     ILE C  83    CG1  CG2  CD1                                       
REMARK 470     ILE C  84    CG1  CG2  CD1                                       
REMARK 470     SER C  85    OG                                                  
REMARK 470     ARG C  86    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     PHE C  87    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     LYS C  88    CG   CD   CE   NZ                                   
REMARK 470     ASN C  89    CG   OD1  ND2                                       
REMARK 470     ASN C  90    CG   OD1  ND2                                       
REMARK 470     ILE C  91    CG1  CG2  CD1                                       
REMARK 470     ASP C  92    CG   OD1  OD2                                       
REMARK 470     GLU C  93    CG   CD   OE1  OE2                                  
REMARK 470     PHE C  94    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ILE C  95    CG1  CG2  CD1                                       
REMARK 470     SER C 105    OG                                                  
REMARK 470     GLN C 106    CG   CD   OE1  NE2                                  
REMARK 470     SER C 107    OG                                                  
REMARK 470     LEU C 108    CG   CD1  CD2                                       
REMARK 470     LYS C 109    CG   CD   CE   NZ                                   
REMARK 470     ILE C 110    CG1  CG2  CD1                                       
REMARK 470     ILE C 112    CG1  CG2  CD1                                       
REMARK 470     LYS C 113    CG   CD   CE   NZ                                   
REMARK 470     GLU C 114    CG   CD   OE1  OE2                                  
REMARK 470     LEU C 115    CG   CD1  CD2                                       
REMARK 470     GLN C 116    CG   CD   OE1  NE2                                  
REMARK 470     ASN C 117    CG   OD1  ND2                                       
REMARK 470     SER C 118    OG                                                  
REMARK 470     CYS C 119    SG                                                  
REMARK 470     SER C 120    OG                                                  
REMARK 470     SER C 121    OG                                                  
REMARK 470     SER C 122    OG                                                  
REMARK 470     LEU C 123    CG   CD1  CD2                                       
REMARK 470     ILE C 124    CG1  CG2  CD1                                       
REMARK 470     HIS C 129    CG   ND1  CD2  CE1  NE2                             
REMARK 470     ASP C 130    CG   OD1  OD2                                       
REMARK 470     TYR C 131    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     ILE C 132    CG1  CG2  CD1                                       
REMARK 470     ARG C 133    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS C 134    CG   CD   CE   NZ                                   
REMARK 470     ILE C 135    CG1  CG2  CD1                                       
REMARK 470     ASP C 136    CG   OD1  OD2                                       
REMARK 470     VAL C 137    CG1  CG2                                            
REMARK 470     LEU C 138    CG   CD1  CD2                                       
REMARK 470     LEU C 139    CG   CD1  CD2                                       
REMARK 470     THR C 140    OG1  CG2                                            
REMARK 470     SER C 141    OG                                                  
REMARK 470     ILE C 142    CG1  CG2  CD1                                       
REMARK 470     ASP C 143    CG   OD1  OD2                                       
REMARK 470     SER C 144    OG                                                  
REMARK 470     ILE C 146    CG1  CG2  CD1                                       
REMARK 470     GLN C 159    CG   CD   OE1  NE2                                  
REMARK 470     LEU C 160    CG   CD1  CD2                                       
REMARK 470     ASN C 161    CG   OD1  ND2                                       
REMARK 470     LYS C 162    CG   CD   CE   NZ                                   
REMARK 470     LEU C 163    CG   CD1  CD2                                       
REMARK 470     ARG C 164    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     SER C 165    OG                                                  
REMARK 470     SER C 166    OG                                                  
REMARK 470     LEU C 167    CG   CD1  CD2                                       
REMARK 470     SER C 168    OG                                                  
REMARK 470     ARG C 169    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     TYR C 170    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     TYR C 173    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     ASN C 174    CG   OD1  ND2                                       
REMARK 470     ASN C 175    CG   OD1  ND2                                       
REMARK 470     ILE C 198    CG1  CG2  CD1                                       
REMARK 470     TYR C 243    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     ILE C 244    CG1  CG2  CD1                                       
REMARK 470     HIS C 281    CG   ND1  CD2  CE1  NE2                             
REMARK 470     ASN C 510    CG   OD1  ND2                                       
REMARK 470     ASP C 511    CG   OD1  OD2                                       
REMARK 470     ASP C 512    CG   OD1  OD2                                       
REMARK 470     LYS C 513    CG   CD   CE   NZ                                   
REMARK 470     HIS C 609    CG   ND1  CD2  CE1  NE2                             
REMARK 470     TYR E  78    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     LYS E  79    CG   CD   CE   NZ                                   
REMARK 470     ARG E  80    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     TYR E  81    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     CYS E  82    SG                                                  
REMARK 470     ILE E  83    CG1  CG2  CD1                                       
REMARK 470     ILE E  84    CG1  CG2  CD1                                       
REMARK 470     SER E  85    OG                                                  
REMARK 470     ARG E  86    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     PHE E  87    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     LYS E  88    CG   CD   CE   NZ                                   
REMARK 470     ASN E  89    CG   OD1  ND2                                       
REMARK 470     ASN E  90    CG   OD1  ND2                                       
REMARK 470     ILE E  91    CG1  CG2  CD1                                       
REMARK 470     ASP E  92    CG   OD1  OD2                                       
REMARK 470     GLU E  93    CG   CD   OE1  OE2                                  
REMARK 470     PHE E  94    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ILE E  95    CG1  CG2  CD1                                       
REMARK 470     SER E 105    OG                                                  
REMARK 470     GLN E 106    CG   CD   OE1  NE2                                  
REMARK 470     SER E 107    OG                                                  
REMARK 470     LEU E 108    CG   CD1  CD2                                       
REMARK 470     LYS E 109    CG   CD   CE   NZ                                   
REMARK 470     ILE E 110    CG1  CG2  CD1                                       
REMARK 470     ILE E 112    CG1  CG2  CD1                                       
REMARK 470     LYS E 113    CG   CD   CE   NZ                                   
REMARK 470     GLU E 114    CG   CD   OE1  OE2                                  
REMARK 470     LEU E 115    CG   CD1  CD2                                       
REMARK 470     GLN E 116    CG   CD   OE1  NE2                                  
REMARK 470     ASN E 117    CG   OD1  ND2                                       
REMARK 470     SER E 118    OG                                                  
REMARK 470     CYS E 119    SG                                                  
REMARK 470     SER E 120    OG                                                  
REMARK 470     SER E 121    OG                                                  
REMARK 470     SER E 122    OG                                                  
REMARK 470     LEU E 123    CG   CD1  CD2                                       
REMARK 470     ILE E 124    CG1  CG2  CD1                                       
REMARK 470     HIS E 129    CG   ND1  CD2  CE1  NE2                             
REMARK 470     ASP E 130    CG   OD1  OD2                                       
REMARK 470     TYR E 131    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     ILE E 132    CG1  CG2  CD1                                       
REMARK 470     ARG E 133    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS E 134    CG   CD   CE   NZ                                   
REMARK 470     ILE E 135    CG1  CG2  CD1                                       
REMARK 470     ASP E 136    CG   OD1  OD2                                       
REMARK 470     VAL E 137    CG1  CG2                                            
REMARK 470     LEU E 138    CG   CD1  CD2                                       
REMARK 470     LEU E 139    CG   CD1  CD2                                       
REMARK 470     THR E 140    OG1  CG2                                            
REMARK 470     SER E 141    OG                                                  
REMARK 470     ILE E 142    CG1  CG2  CD1                                       
REMARK 470     ASP E 143    CG   OD1  OD2                                       
REMARK 470     SER E 144    OG                                                  
REMARK 470     ILE E 146    CG1  CG2  CD1                                       
REMARK 470     GLN E 159    CG   CD   OE1  NE2                                  
REMARK 470     LEU E 160    CG   CD1  CD2                                       
REMARK 470     ASN E 161    CG   OD1  ND2                                       
REMARK 470     LYS E 162    CG   CD   CE   NZ                                   
REMARK 470     LEU E 163    CG   CD1  CD2                                       
REMARK 470     ARG E 164    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     SER E 165    OG                                                  
REMARK 470     SER E 166    OG                                                  
REMARK 470     LEU E 167    CG   CD1  CD2                                       
REMARK 470     SER E 168    OG                                                  
REMARK 470     ARG E 169    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     TYR E 170    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     TYR E 173    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     ASN E 174    CG   OD1  ND2                                       
REMARK 470     ASN E 175    CG   OD1  ND2                                       
REMARK 470     ILE E 198    CG1  CG2  CD1                                       
REMARK 470     TYR E 243    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     ILE E 244    CG1  CG2  CD1                                       
REMARK 470     HIS E 281    CG   ND1  CD2  CE1  NE2                             
REMARK 470     ASN E 510    CG   OD1  ND2                                       
REMARK 470     ASP E 511    CG   OD1  OD2                                       
REMARK 470     ASP E 512    CG   OD1  OD2                                       
REMARK 470     LYS E 513    CG   CD   CE   NZ                                   
REMARK 470     HIS E 609    CG   ND1  CD2  CE1  NE2                             
REMARK 470     ASP B  82    CG   OD1  OD2                                       
REMARK 470     ASN B 130    CG   OD1  ND2                                       
REMARK 470     ILE B 132    CG1  CG2  CD1                                       
REMARK 470     LYS B 133    CG   CD   CE   NZ                                   
REMARK 470     ASP B 135    CG   OD1  OD2                                       
REMARK 470     ASP D  82    CG   OD1  OD2                                       
REMARK 470     ASN D 130    CG   OD1  ND2                                       
REMARK 470     ILE D 132    CG1  CG2  CD1                                       
REMARK 470     LYS D 133    CG   CD   CE   NZ                                   
REMARK 470     ASP D 135    CG   OD1  OD2                                       
REMARK 470     ASP F  82    CG   OD1  OD2                                       
REMARK 470     ASN F 130    CG   OD1  ND2                                       
REMARK 470     ILE F 132    CG1  CG2  CD1                                       
REMARK 470     LYS F 133    CG   CD   CE   NZ                                   
REMARK 470     ASP F 135    CG   OD1  OD2                                       
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    LEU A 115     -169.33   -121.05                                   
REMARK 500    GLU A 194     -164.27   -126.15                                   
REMARK 500    SER A 213     -167.77   -167.83                                   
REMARK 500    LYS A 217     -150.52   -146.62                                   
REMARK 500    ASN A 218      108.81    -43.80                                   
REMARK 500    LYS A 336       58.38    -96.64                                   
REMARK 500    PHE A 357       50.39    -93.78                                   
REMARK 500    THR A 383       74.46   -104.87                                   
REMARK 500    GLN A 421     -168.06   -127.44                                   
REMARK 500    ASP A 439     -167.76   -128.67                                   
REMARK 500    PRO A 443       46.28    -74.03                                   
REMARK 500    THR A 476     -168.51   -126.17                                   
REMARK 500    PHE A 521      118.84   -162.59                                   
REMARK 500    LYS A 557     -158.40    -80.27                                   
REMARK 500    ILE A 644      -61.04   -121.87                                   
REMARK 500    LYS A 660      -70.65    -64.08                                   
REMARK 500    GLU A 671      -10.34     71.51                                   
REMARK 500    GLN A 673       62.38     29.38                                   
REMARK 500    SER A 681       56.11    -90.43                                   
REMARK 500    LEU A 701     -169.10   -124.74                                   
REMARK 500    SER A 706       51.10    -93.14                                   
REMARK 500    ASN A 720       44.92    -89.29                                   
REMARK 500    SER A 721     -164.08   -160.98                                   
REMARK 500    ALA A 722     -157.64   -148.19                                   
REMARK 500    LYS A 774      -10.48     73.25                                   
REMARK 500    ASN A 776       54.28    -96.33                                   
REMARK 500    PHE A 803      107.51   -160.84                                   
REMARK 500    LYS A 809      -61.48    -93.98                                   
REMARK 500    LEU C 115     -169.27   -121.04                                   
REMARK 500    GLU C 194     -164.34   -126.25                                   
REMARK 500    SER C 213     -167.75   -167.82                                   
REMARK 500    LYS C 217     -150.53   -146.65                                   
REMARK 500    ASN C 218      108.83    -43.75                                   
REMARK 500    LYS C 336       58.37    -96.61                                   
REMARK 500    PHE C 357       50.42    -93.70                                   
REMARK 500    THR C 383       74.47   -104.90                                   
REMARK 500    GLN C 421     -168.07   -127.46                                   
REMARK 500    ASP C 439     -167.84   -128.65                                   
REMARK 500    PRO C 443       46.26    -74.02                                   
REMARK 500    THR C 476     -168.49   -126.11                                   
REMARK 500    PHE C 521      118.73   -162.62                                   
REMARK 500    ASN C 548       40.01   -109.83                                   
REMARK 500    LYS C 557     -158.37    -80.30                                   
REMARK 500    ILE C 644      -61.01   -121.82                                   
REMARK 500    LYS C 660      -70.73    -64.00                                   
REMARK 500    GLU C 671      -10.37     71.55                                   
REMARK 500    GLN C 673       62.34     29.45                                   
REMARK 500    SER C 681       56.11    -90.50                                   
REMARK 500    LEU C 701     -169.10   -124.75                                   
REMARK 500    SER C 706       51.12    -93.19                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     107 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS                                         
REMARK 500                                                                      
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH          
REMARK 500 CIS AND TRANS CONFORMATION.  CIS BONDS, IF ANY, ARE LISTED           
REMARK 500 ON CISPEP RECORDS.  TRANS IS DEFINED AS 180 +/- 30 AND               
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.                                  
REMARK 500                                 MODEL     OMEGA                      
REMARK 500 ASN A  218     PRO A  219                 -138.34                    
REMARK 500 LYS A  660     ASN A  661                 -148.02                    
REMARK 500 GLU A  674     ASN A  675                 -146.23                    
REMARK 500 ASN A  675     GLY A  676                  149.81                    
REMARK 500 LEU A  715     LYS A  716                  141.12                    
REMARK 500 ASN C  218     PRO C  219                 -138.30                    
REMARK 500 LYS C  660     ASN C  661                 -147.98                    
REMARK 500 GLU C  674     ASN C  675                 -146.16                    
REMARK 500 ASN C  675     GLY C  676                  149.85                    
REMARK 500 LEU C  715     LYS C  716                  141.22                    
REMARK 500 ASN E  218     PRO E  219                 -138.28                    
REMARK 500 LYS E  660     ASN E  661                 -147.98                    
REMARK 500 GLU E  674     ASN E  675                 -146.16                    
REMARK 500 ASN E  675     GLY E  676                  149.82                    
REMARK 500 LEU E  715     LYS E  716                  141.12                    
REMARK 500 LYS B   60     ILE B   61                  148.43                    
REMARK 500 LYS B   87     ILE B   88                  146.38                    
REMARK 500 LYS D   60     ILE D   61                  148.43                    
REMARK 500 LYS D   87     ILE D   88                  146.36                    
REMARK 500 LYS F   60     ILE F   61                  148.44                    
REMARK 500 LYS F   87     ILE F   88                  146.39                    
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: EMD-20698   RELATED DB: EMDB                             
REMARK 900 RELATED ID: EMD-20696   RELATED DB: EMDB                             
REMARK 900 RELATED ID: EMD-20695   RELATED DB: EMDB                             
DBREF  6U9G A    1   820  UNP    A0Q7H0   A0Q7H0_FRATN     1    820             
DBREF  6U9G C    1   820  UNP    A0Q7H0   A0Q7H0_FRATN     1    820             
DBREF  6U9G E    1   820  UNP    A0Q7H0   A0Q7H0_FRATN     1    820             
DBREF  6U9G B    2   164  UNP    A0Q7H3   A0Q7H3_FRATN     2    164             
DBREF  6U9G D    2   164  UNP    A0Q7H3   A0Q7H3_FRATN     2    164             
DBREF  6U9G F    2   164  UNP    A0Q7H3   A0Q7H3_FRATN     2    164             
SEQADV 6U9G MET B  -24  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G ASP B  -23  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G TYR B  -22  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G LYS B  -21  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G ASP B  -20  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G ASP B  -19  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G ASP B  -18  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G ASP B  -17  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G LYS B  -16  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G ASP B  -15  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G TYR B  -14  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G LYS B  -13  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G ASP B  -12  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G ASP B  -11  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G ASP B  -10  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G ASP B   -9  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G LYS B   -8  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G ASP B   -7  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G TYR B   -6  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G LYS B   -5  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G ASP B   -4  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G ASP B   -3  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G ASP B   -2  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G ASP B   -1  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G LYS B    0  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G GLY B    1  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G MET D  -24  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G ASP D  -23  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G TYR D  -22  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G LYS D  -21  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G ASP D  -20  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G ASP D  -19  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G ASP D  -18  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G ASP D  -17  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G LYS D  -16  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G ASP D  -15  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G TYR D  -14  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G LYS D  -13  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G ASP D  -12  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G ASP D  -11  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G ASP D  -10  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G ASP D   -9  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G LYS D   -8  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G ASP D   -7  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G TYR D   -6  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G LYS D   -5  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G ASP D   -4  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G ASP D   -3  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G ASP D   -2  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G ASP D   -1  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G LYS D    0  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G GLY D    1  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G MET F  -24  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G ASP F  -23  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G TYR F  -22  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G LYS F  -21  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G ASP F  -20  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G ASP F  -19  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G ASP F  -18  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G ASP F  -17  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G LYS F  -16  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G ASP F  -15  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G TYR F  -14  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G LYS F  -13  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G ASP F  -12  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G ASP F  -11  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G ASP F  -10  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G ASP F   -9  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G LYS F   -8  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G ASP F   -7  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G TYR F   -6  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G LYS F   -5  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G ASP F   -4  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G ASP F   -3  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G ASP F   -2  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G ASP F   -1  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G LYS F    0  UNP  A0Q7H3              EXPRESSION TAG                 
SEQADV 6U9G GLY F    1  UNP  A0Q7H3              EXPRESSION TAG                 
SEQRES   1 A  820  MET ILE ALA VAL LYS ASP ILE THR ASP LEU ASN ILE GLN          
SEQRES   2 A  820  ASP ILE ILE SER GLN LEU THR SER GLU VAL ILE ASN GLY          
SEQRES   3 A  820  ASP THR THR PRO SER SER ALA LYS PHE ALA CYS GLU ILE          
SEQRES   4 A  820  ASN SER TYR ILE ILE ASN TYR ASN LEU SER ASN ILE ASN          
SEQRES   5 A  820  LEU ILE ASN THR GLN LEU LYS ASN THR LYS ILE LEU TYR          
SEQRES   6 A  820  ARG LYS GLY LEU ILE SER LYS LEU ASP TYR GLU LYS TYR          
SEQRES   7 A  820  LYS ARG TYR CYS ILE ILE SER ARG PHE LYS ASN ASN ILE          
SEQRES   8 A  820  ASP GLU PHE ILE LEU TYR PHE SER THR ASN TYR LYS ASP          
SEQRES   9 A  820  SER GLN SER LEU LYS ILE ALA ILE LYS GLU LEU GLN ASN          
SEQRES  10 A  820  SER CYS SER SER SER LEU ILE LEU GLU LEU PRO HIS ASP          
SEQRES  11 A  820  TYR ILE ARG LYS ILE ASP VAL LEU LEU THR SER ILE ASP          
SEQRES  12 A  820  SER ALA ILE GLN ARG SER SER ASP LEU ASN LYS THR ILE          
SEQRES  13 A  820  ILE LYS GLN LEU ASN LYS LEU ARG SER SER LEU SER ARG          
SEQRES  14 A  820  TYR ILE GLY TYR ASN ASN VAL LEU GLN LYS GLN GLU ILE          
SEQRES  15 A  820  THR ILE ASN ILE LYS PRO ILE ASN LYS ASN PHE GLU LEU          
SEQRES  16 A  820  GLU ASP ILE SER PHE VAL SER THR ARG ASN LYS GLN TYR          
SEQRES  17 A  820  PHE LYS HIS ASN SER LEU THR LEU LYS ASN PRO HIS ILE          
SEQRES  18 A  820  GLU LYS LEU GLU VAL CYS GLU ASN ILE TYR GLY ILE ASN          
SEQRES  19 A  820  GLY TRP LEU THR PHE ASP LEU ALA TYR ILE ASN ASN HIS          
SEQRES  20 A  820  LYS ASP PHE ASN PHE LEU LEU SER PRO ASN GLN PRO ILE          
SEQRES  21 A  820  LEU LEU ASP ILE GLN ILE ASN ASP SER PHE ASN PHE TYR          
SEQRES  22 A  820  LYS LYS GLU SER LYS LYS ASP HIS HIS LYS ARG THR THR          
SEQRES  23 A  820  ARG PHE ILE ALA ILE GLY PHE ASN SER ASN SER ILE ASP          
SEQRES  24 A  820  ILE HIS GLU ASN PHE GLU TYR SER ILE TYR SER TYR THR          
SEQRES  25 A  820  LYS ASN VAL SER SER GLY VAL LYS LYS PHE LYS ILE GLN          
SEQRES  26 A  820  PHE HIS ASP PRO LEU LYS ALA LEU TRP THR LYS HIS LYS          
SEQRES  27 A  820  PRO SER TYR ILE ALA LEU ASN LYS SER LEU ASP ASP ILE          
SEQRES  28 A  820  PHE LYS ASP ASN PHE PHE PHE ASP SER LEU PHE SER LEU          
SEQRES  29 A  820  ASP THR ASN LYS SER ASN ASN LEU LYS ILE ARG ILE PRO          
SEQRES  30 A  820  GLN ALA PHE ILE SER THR VAL ASN ARG ASN PHE TYR ASP          
SEQRES  31 A  820  PHE PHE ILE GLN GLN LEU GLU GLN ASN LYS CYS TYR LEU          
SEQRES  32 A  820  LYS TYR PHE CYS ASP LYS LYS SER GLY LYS VAL SER TYR          
SEQRES  33 A  820  HIS VAL VAL ASP GLN VAL ASP ASN ASP LEU GLN ARG ASN          
SEQRES  34 A  820  ILE VAL ASN SER ASP GLU ASP LEU LYS ASP LYS LEU SER          
SEQRES  35 A  820  PRO TYR ASP ILE SER CYS PHE LYS LYS GLN ILE LEU ILE          
SEQRES  36 A  820  SER ASN LYS SER ASN PHE TYR VAL LYS GLU LYS ASN ILE          
SEQRES  37 A  820  CYS PRO ASP VAL THR LEU ASN THR GLN ARG LYS GLU ASP          
SEQRES  38 A  820  ARG LYS ILE SER ASP THR LEU VAL LYS PRO PHE SER SER          
SEQRES  39 A  820  ILE LEU LYS ASP ASN LEU GLN SER VAL GLU TYR ILE GLN          
SEQRES  40 A  820  SER ASN ASN ASP ASP LYS GLN GLU ILE ILE THR THR GLY          
SEQRES  41 A  820  PHE GLU ILE LEU LEU THR SER ARG ASN THR LEU PRO PHE          
SEQRES  42 A  820  LEU ASP THR GLU ILE THR LEU SER LYS LEU ASP ASN ASP          
SEQRES  43 A  820  GLN ASN TYR LEU LEU GLY ALA THR ASP ILE LYS SER LEU          
SEQRES  44 A  820  TYR ILE SER GLN ARG LYS LEU LEU PHE LYS ARG SER LYS          
SEQRES  45 A  820  TYR CYS SER LYS GLN LEU TYR GLU ASN LEU HIS ASN PHE          
SEQRES  46 A  820  HIS TYR LYS SER ASP SER GLU SER ASP VAL TYR GLU LYS          
SEQRES  47 A  820  ILE ALA PHE THR LYS TYR PRO SER LEU THR HIS ASP ASN          
SEQRES  48 A  820  SER ILE THR TYR LYS ILE LYS ASP TYR SER ASN LEU THR          
SEQRES  49 A  820  PRO GLU TYR PRO LYS TYR LYS SER PHE SER ASN PHE TYR          
SEQRES  50 A  820  ILE ASN GLY ARG ILE THR ILE GLY GLU ASN VAL ASN ASN          
SEQRES  51 A  820  ASP SER LYS LYS ALA TYR LYS PHE PHE LYS ASN HIS LYS          
SEQRES  52 A  820  PRO GLU GLU SER SER ILE ALA GLU PHE GLN GLU ASN GLY          
SEQRES  53 A  820  GLU LYS GLY THR SER ALA ILE LEU ASN SER LYS ALA ASP          
SEQRES  54 A  820  ILE LEU TYR ALA ILE GLU ILE ALA LYS GLU MET LEU SER          
SEQRES  55 A  820  ASP LYS SER SER ASP LYS PRO ILE ILE TYR LEU PRO LEU          
SEQRES  56 A  820  LYS VAL ASN ILE ASN SER ALA ASN ASN GLN PHE ILE PRO          
SEQRES  57 A  820  LEU ARG ASN ASP ASP ILE ILE LEU ILE GLU ILE GLN SER          
SEQRES  58 A  820  PHE THR LYS GLY GLU ILE ILE GLU LEU ILE SER ASN SER          
SEQRES  59 A  820  ALA ILE SER THR LYS LYS ALA GLN GLN GLN LEU LEU GLN          
SEQRES  60 A  820  ARG GLN LEU LEU GLY SER LYS GLU ASN CYS GLU MET ALA          
SEQRES  61 A  820  TYR THR GLN THR SER ASP SER GLU THR PHE SER LEU THR          
SEQRES  62 A  820  GLN VAL ASN GLU ASP CYS GLU ASN SER PHE LEU ILE ASN          
SEQRES  63 A  820  ASP LYS LYS GLY ILE PHE LEU ARG TYR LYS SER LYS GLY          
SEQRES  64 A  820  ASN                                                          
SEQRES   1 C  820  MET ILE ALA VAL LYS ASP ILE THR ASP LEU ASN ILE GLN          
SEQRES   2 C  820  ASP ILE ILE SER GLN LEU THR SER GLU VAL ILE ASN GLY          
SEQRES   3 C  820  ASP THR THR PRO SER SER ALA LYS PHE ALA CYS GLU ILE          
SEQRES   4 C  820  ASN SER TYR ILE ILE ASN TYR ASN LEU SER ASN ILE ASN          
SEQRES   5 C  820  LEU ILE ASN THR GLN LEU LYS ASN THR LYS ILE LEU TYR          
SEQRES   6 C  820  ARG LYS GLY LEU ILE SER LYS LEU ASP TYR GLU LYS TYR          
SEQRES   7 C  820  LYS ARG TYR CYS ILE ILE SER ARG PHE LYS ASN ASN ILE          
SEQRES   8 C  820  ASP GLU PHE ILE LEU TYR PHE SER THR ASN TYR LYS ASP          
SEQRES   9 C  820  SER GLN SER LEU LYS ILE ALA ILE LYS GLU LEU GLN ASN          
SEQRES  10 C  820  SER CYS SER SER SER LEU ILE LEU GLU LEU PRO HIS ASP          
SEQRES  11 C  820  TYR ILE ARG LYS ILE ASP VAL LEU LEU THR SER ILE ASP          
SEQRES  12 C  820  SER ALA ILE GLN ARG SER SER ASP LEU ASN LYS THR ILE          
SEQRES  13 C  820  ILE LYS GLN LEU ASN LYS LEU ARG SER SER LEU SER ARG          
SEQRES  14 C  820  TYR ILE GLY TYR ASN ASN VAL LEU GLN LYS GLN GLU ILE          
SEQRES  15 C  820  THR ILE ASN ILE LYS PRO ILE ASN LYS ASN PHE GLU LEU          
SEQRES  16 C  820  GLU ASP ILE SER PHE VAL SER THR ARG ASN LYS GLN TYR          
SEQRES  17 C  820  PHE LYS HIS ASN SER LEU THR LEU LYS ASN PRO HIS ILE          
SEQRES  18 C  820  GLU LYS LEU GLU VAL CYS GLU ASN ILE TYR GLY ILE ASN          
SEQRES  19 C  820  GLY TRP LEU THR PHE ASP LEU ALA TYR ILE ASN ASN HIS          
SEQRES  20 C  820  LYS ASP PHE ASN PHE LEU LEU SER PRO ASN GLN PRO ILE          
SEQRES  21 C  820  LEU LEU ASP ILE GLN ILE ASN ASP SER PHE ASN PHE TYR          
SEQRES  22 C  820  LYS LYS GLU SER LYS LYS ASP HIS HIS LYS ARG THR THR          
SEQRES  23 C  820  ARG PHE ILE ALA ILE GLY PHE ASN SER ASN SER ILE ASP          
SEQRES  24 C  820  ILE HIS GLU ASN PHE GLU TYR SER ILE TYR SER TYR THR          
SEQRES  25 C  820  LYS ASN VAL SER SER GLY VAL LYS LYS PHE LYS ILE GLN          
SEQRES  26 C  820  PHE HIS ASP PRO LEU LYS ALA LEU TRP THR LYS HIS LYS          
SEQRES  27 C  820  PRO SER TYR ILE ALA LEU ASN LYS SER LEU ASP ASP ILE          
SEQRES  28 C  820  PHE LYS ASP ASN PHE PHE PHE ASP SER LEU PHE SER LEU          
SEQRES  29 C  820  ASP THR ASN LYS SER ASN ASN LEU LYS ILE ARG ILE PRO          
SEQRES  30 C  820  GLN ALA PHE ILE SER THR VAL ASN ARG ASN PHE TYR ASP          
SEQRES  31 C  820  PHE PHE ILE GLN GLN LEU GLU GLN ASN LYS CYS TYR LEU          
SEQRES  32 C  820  LYS TYR PHE CYS ASP LYS LYS SER GLY LYS VAL SER TYR          
SEQRES  33 C  820  HIS VAL VAL ASP GLN VAL ASP ASN ASP LEU GLN ARG ASN          
SEQRES  34 C  820  ILE VAL ASN SER ASP GLU ASP LEU LYS ASP LYS LEU SER          
SEQRES  35 C  820  PRO TYR ASP ILE SER CYS PHE LYS LYS GLN ILE LEU ILE          
SEQRES  36 C  820  SER ASN LYS SER ASN PHE TYR VAL LYS GLU LYS ASN ILE          
SEQRES  37 C  820  CYS PRO ASP VAL THR LEU ASN THR GLN ARG LYS GLU ASP          
SEQRES  38 C  820  ARG LYS ILE SER ASP THR LEU VAL LYS PRO PHE SER SER          
SEQRES  39 C  820  ILE LEU LYS ASP ASN LEU GLN SER VAL GLU TYR ILE GLN          
SEQRES  40 C  820  SER ASN ASN ASP ASP LYS GLN GLU ILE ILE THR THR GLY          
SEQRES  41 C  820  PHE GLU ILE LEU LEU THR SER ARG ASN THR LEU PRO PHE          
SEQRES  42 C  820  LEU ASP THR GLU ILE THR LEU SER LYS LEU ASP ASN ASP          
SEQRES  43 C  820  GLN ASN TYR LEU LEU GLY ALA THR ASP ILE LYS SER LEU          
SEQRES  44 C  820  TYR ILE SER GLN ARG LYS LEU LEU PHE LYS ARG SER LYS          
SEQRES  45 C  820  TYR CYS SER LYS GLN LEU TYR GLU ASN LEU HIS ASN PHE          
SEQRES  46 C  820  HIS TYR LYS SER ASP SER GLU SER ASP VAL TYR GLU LYS          
SEQRES  47 C  820  ILE ALA PHE THR LYS TYR PRO SER LEU THR HIS ASP ASN          
SEQRES  48 C  820  SER ILE THR TYR LYS ILE LYS ASP TYR SER ASN LEU THR          
SEQRES  49 C  820  PRO GLU TYR PRO LYS TYR LYS SER PHE SER ASN PHE TYR          
SEQRES  50 C  820  ILE ASN GLY ARG ILE THR ILE GLY GLU ASN VAL ASN ASN          
SEQRES  51 C  820  ASP SER LYS LYS ALA TYR LYS PHE PHE LYS ASN HIS LYS          
SEQRES  52 C  820  PRO GLU GLU SER SER ILE ALA GLU PHE GLN GLU ASN GLY          
SEQRES  53 C  820  GLU LYS GLY THR SER ALA ILE LEU ASN SER LYS ALA ASP          
SEQRES  54 C  820  ILE LEU TYR ALA ILE GLU ILE ALA LYS GLU MET LEU SER          
SEQRES  55 C  820  ASP LYS SER SER ASP LYS PRO ILE ILE TYR LEU PRO LEU          
SEQRES  56 C  820  LYS VAL ASN ILE ASN SER ALA ASN ASN GLN PHE ILE PRO          
SEQRES  57 C  820  LEU ARG ASN ASP ASP ILE ILE LEU ILE GLU ILE GLN SER          
SEQRES  58 C  820  PHE THR LYS GLY GLU ILE ILE GLU LEU ILE SER ASN SER          
SEQRES  59 C  820  ALA ILE SER THR LYS LYS ALA GLN GLN GLN LEU LEU GLN          
SEQRES  60 C  820  ARG GLN LEU LEU GLY SER LYS GLU ASN CYS GLU MET ALA          
SEQRES  61 C  820  TYR THR GLN THR SER ASP SER GLU THR PHE SER LEU THR          
SEQRES  62 C  820  GLN VAL ASN GLU ASP CYS GLU ASN SER PHE LEU ILE ASN          
SEQRES  63 C  820  ASP LYS LYS GLY ILE PHE LEU ARG TYR LYS SER LYS GLY          
SEQRES  64 C  820  ASN                                                          
SEQRES   1 E  820  MET ILE ALA VAL LYS ASP ILE THR ASP LEU ASN ILE GLN          
SEQRES   2 E  820  ASP ILE ILE SER GLN LEU THR SER GLU VAL ILE ASN GLY          
SEQRES   3 E  820  ASP THR THR PRO SER SER ALA LYS PHE ALA CYS GLU ILE          
SEQRES   4 E  820  ASN SER TYR ILE ILE ASN TYR ASN LEU SER ASN ILE ASN          
SEQRES   5 E  820  LEU ILE ASN THR GLN LEU LYS ASN THR LYS ILE LEU TYR          
SEQRES   6 E  820  ARG LYS GLY LEU ILE SER LYS LEU ASP TYR GLU LYS TYR          
SEQRES   7 E  820  LYS ARG TYR CYS ILE ILE SER ARG PHE LYS ASN ASN ILE          
SEQRES   8 E  820  ASP GLU PHE ILE LEU TYR PHE SER THR ASN TYR LYS ASP          
SEQRES   9 E  820  SER GLN SER LEU LYS ILE ALA ILE LYS GLU LEU GLN ASN          
SEQRES  10 E  820  SER CYS SER SER SER LEU ILE LEU GLU LEU PRO HIS ASP          
SEQRES  11 E  820  TYR ILE ARG LYS ILE ASP VAL LEU LEU THR SER ILE ASP          
SEQRES  12 E  820  SER ALA ILE GLN ARG SER SER ASP LEU ASN LYS THR ILE          
SEQRES  13 E  820  ILE LYS GLN LEU ASN LYS LEU ARG SER SER LEU SER ARG          
SEQRES  14 E  820  TYR ILE GLY TYR ASN ASN VAL LEU GLN LYS GLN GLU ILE          
SEQRES  15 E  820  THR ILE ASN ILE LYS PRO ILE ASN LYS ASN PHE GLU LEU          
SEQRES  16 E  820  GLU ASP ILE SER PHE VAL SER THR ARG ASN LYS GLN TYR          
SEQRES  17 E  820  PHE LYS HIS ASN SER LEU THR LEU LYS ASN PRO HIS ILE          
SEQRES  18 E  820  GLU LYS LEU GLU VAL CYS GLU ASN ILE TYR GLY ILE ASN          
SEQRES  19 E  820  GLY TRP LEU THR PHE ASP LEU ALA TYR ILE ASN ASN HIS          
SEQRES  20 E  820  LYS ASP PHE ASN PHE LEU LEU SER PRO ASN GLN PRO ILE          
SEQRES  21 E  820  LEU LEU ASP ILE GLN ILE ASN ASP SER PHE ASN PHE TYR          
SEQRES  22 E  820  LYS LYS GLU SER LYS LYS ASP HIS HIS LYS ARG THR THR          
SEQRES  23 E  820  ARG PHE ILE ALA ILE GLY PHE ASN SER ASN SER ILE ASP          
SEQRES  24 E  820  ILE HIS GLU ASN PHE GLU TYR SER ILE TYR SER TYR THR          
SEQRES  25 E  820  LYS ASN VAL SER SER GLY VAL LYS LYS PHE LYS ILE GLN          
SEQRES  26 E  820  PHE HIS ASP PRO LEU LYS ALA LEU TRP THR LYS HIS LYS          
SEQRES  27 E  820  PRO SER TYR ILE ALA LEU ASN LYS SER LEU ASP ASP ILE          
SEQRES  28 E  820  PHE LYS ASP ASN PHE PHE PHE ASP SER LEU PHE SER LEU          
SEQRES  29 E  820  ASP THR ASN LYS SER ASN ASN LEU LYS ILE ARG ILE PRO          
SEQRES  30 E  820  GLN ALA PHE ILE SER THR VAL ASN ARG ASN PHE TYR ASP          
SEQRES  31 E  820  PHE PHE ILE GLN GLN LEU GLU GLN ASN LYS CYS TYR LEU          
SEQRES  32 E  820  LYS TYR PHE CYS ASP LYS LYS SER GLY LYS VAL SER TYR          
SEQRES  33 E  820  HIS VAL VAL ASP GLN VAL ASP ASN ASP LEU GLN ARG ASN          
SEQRES  34 E  820  ILE VAL ASN SER ASP GLU ASP LEU LYS ASP LYS LEU SER          
SEQRES  35 E  820  PRO TYR ASP ILE SER CYS PHE LYS LYS GLN ILE LEU ILE          
SEQRES  36 E  820  SER ASN LYS SER ASN PHE TYR VAL LYS GLU LYS ASN ILE          
SEQRES  37 E  820  CYS PRO ASP VAL THR LEU ASN THR GLN ARG LYS GLU ASP          
SEQRES  38 E  820  ARG LYS ILE SER ASP THR LEU VAL LYS PRO PHE SER SER          
SEQRES  39 E  820  ILE LEU LYS ASP ASN LEU GLN SER VAL GLU TYR ILE GLN          
SEQRES  40 E  820  SER ASN ASN ASP ASP LYS GLN GLU ILE ILE THR THR GLY          
SEQRES  41 E  820  PHE GLU ILE LEU LEU THR SER ARG ASN THR LEU PRO PHE          
SEQRES  42 E  820  LEU ASP THR GLU ILE THR LEU SER LYS LEU ASP ASN ASP          
SEQRES  43 E  820  GLN ASN TYR LEU LEU GLY ALA THR ASP ILE LYS SER LEU          
SEQRES  44 E  820  TYR ILE SER GLN ARG LYS LEU LEU PHE LYS ARG SER LYS          
SEQRES  45 E  820  TYR CYS SER LYS GLN LEU TYR GLU ASN LEU HIS ASN PHE          
SEQRES  46 E  820  HIS TYR LYS SER ASP SER GLU SER ASP VAL TYR GLU LYS          
SEQRES  47 E  820  ILE ALA PHE THR LYS TYR PRO SER LEU THR HIS ASP ASN          
SEQRES  48 E  820  SER ILE THR TYR LYS ILE LYS ASP TYR SER ASN LEU THR          
SEQRES  49 E  820  PRO GLU TYR PRO LYS TYR LYS SER PHE SER ASN PHE TYR          
SEQRES  50 E  820  ILE ASN GLY ARG ILE THR ILE GLY GLU ASN VAL ASN ASN          
SEQRES  51 E  820  ASP SER LYS LYS ALA TYR LYS PHE PHE LYS ASN HIS LYS          
SEQRES  52 E  820  PRO GLU GLU SER SER ILE ALA GLU PHE GLN GLU ASN GLY          
SEQRES  53 E  820  GLU LYS GLY THR SER ALA ILE LEU ASN SER LYS ALA ASP          
SEQRES  54 E  820  ILE LEU TYR ALA ILE GLU ILE ALA LYS GLU MET LEU SER          
SEQRES  55 E  820  ASP LYS SER SER ASP LYS PRO ILE ILE TYR LEU PRO LEU          
SEQRES  56 E  820  LYS VAL ASN ILE ASN SER ALA ASN ASN GLN PHE ILE PRO          
SEQRES  57 E  820  LEU ARG ASN ASP ASP ILE ILE LEU ILE GLU ILE GLN SER          
SEQRES  58 E  820  PHE THR LYS GLY GLU ILE ILE GLU LEU ILE SER ASN SER          
SEQRES  59 E  820  ALA ILE SER THR LYS LYS ALA GLN GLN GLN LEU LEU GLN          
SEQRES  60 E  820  ARG GLN LEU LEU GLY SER LYS GLU ASN CYS GLU MET ALA          
SEQRES  61 E  820  TYR THR GLN THR SER ASP SER GLU THR PHE SER LEU THR          
SEQRES  62 E  820  GLN VAL ASN GLU ASP CYS GLU ASN SER PHE LEU ILE ASN          
SEQRES  63 E  820  ASP LYS LYS GLY ILE PHE LEU ARG TYR LYS SER LYS GLY          
SEQRES  64 E  820  ASN                                                          
SEQRES   1 B  189  MET ASP TYR LYS ASP ASP ASP ASP LYS ASP TYR LYS ASP          
SEQRES   2 B  189  ASP ASP ASP LYS ASP TYR LYS ASP ASP ASP ASP LYS GLY          
SEQRES   3 B  189  SER LYS ALA ASP HIS ILE PHE ASN LEU GLU GLU GLN GLY          
SEQRES   4 B  189  LEU LEU ILE ASP ILE LYS ASP ASP SER LYS GLY CYS THR          
SEQRES   5 B  189  THR LYS LEU GLU SER SER GLY LYS ILE THR HIS ASN ALA          
SEQRES   6 B  189  THR GLU SER ILE GLU SER SER ALA ASP LYS GLN ILE ILE          
SEQRES   7 B  189  GLU ASN VAL LYS ASP SER LYS ILE SER ILE THR GLU LYS          
SEQRES   8 B  189  GLU ILE LEU LEU ALA THR LYS LYS SER SER ILE MET LEU          
SEQRES   9 B  189  SER GLU ASP LYS ILE VAL ILE LYS ILE GLY ASN SER LEU          
SEQRES  10 B  189  ILE ILE LEU ASP ASP SER ASN ILE SER LEU GLU SER ALA          
SEQRES  11 B  189  THR ILE ASN ILE LYS SER SER ALA ASN ILE ASN ILE GLN          
SEQRES  12 B  189  ALA SER GLN ASN ILE ASP ILE LYS SER LEU ASN ASN SER          
SEQRES  13 B  189  ILE LYS ALA ASP VAL ASN LEU ASN ALA GLU GLY LEU ASP          
SEQRES  14 B  189  VAL ASN ILE LYS GLY SER VAL THR ALA SER ILE LYS GLY          
SEQRES  15 B  189  SER ALA ALA THR MET VAL GLY                                  
SEQRES   1 D  189  MET ASP TYR LYS ASP ASP ASP ASP LYS ASP TYR LYS ASP          
SEQRES   2 D  189  ASP ASP ASP LYS ASP TYR LYS ASP ASP ASP ASP LYS GLY          
SEQRES   3 D  189  SER LYS ALA ASP HIS ILE PHE ASN LEU GLU GLU GLN GLY          
SEQRES   4 D  189  LEU LEU ILE ASP ILE LYS ASP ASP SER LYS GLY CYS THR          
SEQRES   5 D  189  THR LYS LEU GLU SER SER GLY LYS ILE THR HIS ASN ALA          
SEQRES   6 D  189  THR GLU SER ILE GLU SER SER ALA ASP LYS GLN ILE ILE          
SEQRES   7 D  189  GLU ASN VAL LYS ASP SER LYS ILE SER ILE THR GLU LYS          
SEQRES   8 D  189  GLU ILE LEU LEU ALA THR LYS LYS SER SER ILE MET LEU          
SEQRES   9 D  189  SER GLU ASP LYS ILE VAL ILE LYS ILE GLY ASN SER LEU          
SEQRES  10 D  189  ILE ILE LEU ASP ASP SER ASN ILE SER LEU GLU SER ALA          
SEQRES  11 D  189  THR ILE ASN ILE LYS SER SER ALA ASN ILE ASN ILE GLN          
SEQRES  12 D  189  ALA SER GLN ASN ILE ASP ILE LYS SER LEU ASN ASN SER          
SEQRES  13 D  189  ILE LYS ALA ASP VAL ASN LEU ASN ALA GLU GLY LEU ASP          
SEQRES  14 D  189  VAL ASN ILE LYS GLY SER VAL THR ALA SER ILE LYS GLY          
SEQRES  15 D  189  SER ALA ALA THR MET VAL GLY                                  
SEQRES   1 F  189  MET ASP TYR LYS ASP ASP ASP ASP LYS ASP TYR LYS ASP          
SEQRES   2 F  189  ASP ASP ASP LYS ASP TYR LYS ASP ASP ASP ASP LYS GLY          
SEQRES   3 F  189  SER LYS ALA ASP HIS ILE PHE ASN LEU GLU GLU GLN GLY          
SEQRES   4 F  189  LEU LEU ILE ASP ILE LYS ASP ASP SER LYS GLY CYS THR          
SEQRES   5 F  189  THR LYS LEU GLU SER SER GLY LYS ILE THR HIS ASN ALA          
SEQRES   6 F  189  THR GLU SER ILE GLU SER SER ALA ASP LYS GLN ILE ILE          
SEQRES   7 F  189  GLU ASN VAL LYS ASP SER LYS ILE SER ILE THR GLU LYS          
SEQRES   8 F  189  GLU ILE LEU LEU ALA THR LYS LYS SER SER ILE MET LEU          
SEQRES   9 F  189  SER GLU ASP LYS ILE VAL ILE LYS ILE GLY ASN SER LEU          
SEQRES  10 F  189  ILE ILE LEU ASP ASP SER ASN ILE SER LEU GLU SER ALA          
SEQRES  11 F  189  THR ILE ASN ILE LYS SER SER ALA ASN ILE ASN ILE GLN          
SEQRES  12 F  189  ALA SER GLN ASN ILE ASP ILE LYS SER LEU ASN ASN SER          
SEQRES  13 F  189  ILE LYS ALA ASP VAL ASN LEU ASN ALA GLU GLY LEU ASP          
SEQRES  14 F  189  VAL ASN ILE LYS GLY SER VAL THR ALA SER ILE LYS GLY          
SEQRES  15 F  189  SER ALA ALA THR MET VAL GLY                                  
HELIX    1 AA1 LYS A   79  ASP A   92  1                                  14    
HELIX    2 AA2 GLU A   93  ILE A   95  5                                   3    
HELIX    3 AA3 GLN A  106  LEU A  115  1                                  10    
HELIX    4 AA4 CYS A  119  ILE A  124  1                                   6    
HELIX    5 AA5 TYR A  131  SER A  144  1                                  14    
HELIX    6 AA6 ASN A  161  ILE A  171  1                                  11    
HELIX    7 AA7 ASN A  246  LYS A  248  5                                   3    
HELIX    8 AA8 ASP A  249  LEU A  254  1                                   6    
HELIX    9 AA9 ASP A  328  THR A  335  1                                   8    
HELIX   10 AB1 SER A  347  LYS A  353  1                                   7    
HELIX   11 AB2 ASN A  387  GLN A  398  1                                  12    
HELIX   12 AB3 ASP A  423  ARG A  428  1                                   6    
HELIX   13 AB4 SER A  571  ASN A  581  1                                  11    
HELIX   14 AB5 SER A  621  LEU A  623  5                                   3    
HELIX   15 AB6 GLY A  772  ASN A  776  5                                   5    
HELIX   16 AB7 LYS C   79  ASP C   92  1                                  14    
HELIX   17 AB8 GLU C   93  ILE C   95  5                                   3    
HELIX   18 AB9 GLN C  106  LEU C  115  1                                  10    
HELIX   19 AC1 CYS C  119  ILE C  124  1                                   6    
HELIX   20 AC2 TYR C  131  SER C  144  1                                  14    
HELIX   21 AC3 ASN C  161  ILE C  171  1                                  11    
HELIX   22 AC4 ASN C  246  LYS C  248  5                                   3    
HELIX   23 AC5 ASP C  249  LEU C  254  1                                   6    
HELIX   24 AC6 ASP C  328  THR C  335  1                                   8    
HELIX   25 AC7 SER C  347  LYS C  353  1                                   7    
HELIX   26 AC8 ASN C  387  GLN C  398  1                                  12    
HELIX   27 AC9 ASP C  423  ARG C  428  1                                   6    
HELIX   28 AD1 SER C  571  ASN C  581  1                                  11    
HELIX   29 AD2 SER C  621  LEU C  623  5                                   3    
HELIX   30 AD3 GLY C  772  ASN C  776  5                                   5    
HELIX   31 AD4 LYS E   79  ASP E   92  1                                  14    
HELIX   32 AD5 GLU E   93  ILE E   95  5                                   3    
HELIX   33 AD6 GLN E  106  LEU E  115  1                                  10    
HELIX   34 AD7 CYS E  119  ILE E  124  1                                   6    
HELIX   35 AD8 TYR E  131  SER E  144  1                                  14    
HELIX   36 AD9 ASN E  161  ILE E  171  1                                  11    
HELIX   37 AE1 ASN E  246  LYS E  248  5                                   3    
HELIX   38 AE2 ASP E  249  LEU E  254  1                                   6    
HELIX   39 AE3 ASP E  328  THR E  335  1                                   8    
HELIX   40 AE4 SER E  347  LYS E  353  1                                   7    
HELIX   41 AE5 ASN E  387  GLN E  398  1                                  12    
HELIX   42 AE6 ASP E  423  ARG E  428  1                                   6    
HELIX   43 AE7 SER E  571  ASN E  581  1                                  11    
HELIX   44 AE8 SER E  621  LEU E  623  5                                   3    
HELIX   45 AE9 GLY E  772  ASN E  776  5                                   5    
SHEET    1 AA1 3 LYS A 179  PRO A 188  0                                        
SHEET    2 AA1 3 ILE A 260  SER A 269 -1  O  LEU A 261   N  LYS A 187           
SHEET    3 AA1 3 LYS A 283  ILE A 291 -1  O  PHE A 288   N  ILE A 264           
SHEET    1 AA2 4 ILE A 233  ASN A 234  0                                        
SHEET    2 AA2 4 ILE A 221  GLU A 228 -1  N  CYS A 227   O  ASN A 234           
SHEET    3 AA2 4 TRP A 236  LEU A 241 -1  O  THR A 238   N  GLU A 222           
SHEET    4 AA2 4 LYS A 320  GLN A 325 -1  O  LYS A 320   N  LEU A 241           
SHEET    1 AA3 6 ILE A 233  ASN A 234  0                                        
SHEET    2 AA3 6 ILE A 221  GLU A 228 -1  N  CYS A 227   O  ASN A 234           
SHEET    3 AA3 6 LEU A 559  LYS A 569 -1  O  LEU A 566   N  VAL A 226           
SHEET    4 AA3 6 ILE A 613  ASP A 619 -1  O  LYS A 618   N  TYR A 560           
SHEET    5 AA3 6 ILE A 523  LEU A 525 -1  N  ILE A 523   O  ILE A 617           
SHEET    6 AA3 6 GLN A 452  LEU A 454 -1  N  ILE A 453   O  LEU A 524           
SHEET    1 AA4 2 ILE A 342  LEU A 344  0                                        
SHEET    2 AA4 2 GLN A 378  PHE A 380 -1  O  ALA A 379   N  ALA A 343           
SHEET    1 AA5 2 SER A 363  ASP A 365  0                                        
SHEET    2 AA5 2 SER A 415  HIS A 417  1  O  TYR A 416   N  ASP A 365           
SHEET    1 AA6 3 LYS A 479  ASP A 481  0                                        
SHEET    2 AA6 3 PHE A 461  ILE A 468 -1  N  ASN A 467   O  GLU A 480           
SHEET    3 AA6 3 LYS A 490  LEU A 500  1  O  ASN A 499   N  LYS A 466           
SHEET    1 AA7 5 ILE A 710  PRO A 714  0                                        
SHEET    2 AA7 5 LEU A 691  GLU A 695 -1  N  ILE A 694   O  ILE A 711           
SHEET    3 AA7 5 TYR A 637  ILE A 642 -1  N  ARG A 641   O  GLU A 695           
SHEET    4 AA7 5 ILE A 734  SER A 741 -1  O  ILE A 735   N  GLY A 640           
SHEET    5 AA7 5 LYS A 744  LEU A 750 -1  O  GLU A 746   N  GLU A 738           
SHEET    1 AA8 2 ILE A 683  LEU A 684  0                                        
SHEET    2 AA8 2 SER C 752  ASN C 753 -1  O  ASN C 753   N  ILE A 683           
SHEET    1 AA9 2 SER A 752  ASN A 753  0                                        
SHEET    2 AA9 2 ILE E 683  LEU E 684 -1  O  ILE E 683   N  ASN A 753           
SHEET    1 AB118 GLU A 778  GLN A 783  0                                        
SHEET    2 AB118 GLU A 788  THR A 793 -1  O  THR A 789   N  THR A 782           
SHEET    3 AB118 GLU A 800  ILE A 805 -1  O  ILE A 805   N  PHE A 790           
SHEET    4 AB118 ILE A 811  LYS A 816 -1  O  PHE A 812   N  LEU A 804           
SHEET    5 AB118 ASP B   5  PHE B   8 -1  O  HIS B   6   N  TYR A 815           
SHEET    6 AB118 GLY B  14  LYS B  20 -1  O  LYS B  20   N  ASP B   5           
SHEET    7 AB118 CYS B  26  GLU B  31 -1  O  THR B  28   N  ILE B  17           
SHEET    8 AB118 ILE B  36  HIS B  38 -1  O  THR B  37   N  LYS B  29           
SHEET    9 AB118 SER F  43  SER F  46  1  O  GLU F  45   N  ILE B  36           
SHEET   10 AB118 GLN D  51  ILE D  53  1  N  ILE D  53   O  SER F  46           
SHEET   11 AB118 ILE D  61  ILE D  63 -1  O  ILE D  63   N  ILE D  52           
SHEET   12 AB118 ILE D  68  THR D  72 -1  O  LEU D  69   N  SER D  62           
SHEET   13 AB118 SER D  75  SER D  80 -1  O  SER D  75   N  THR D  72           
SHEET   14 AB118 LYS D  83  ILE D  88 -1  O  VAL D  85   N  MET D  78           
SHEET   15 AB118 SER D  91  LEU D  95 -1  O  SER D  91   N  ILE D  88           
SHEET   16 AB118 ILE D 100  SER D 104 -1  O  GLU D 103   N  LEU D  92           
SHEET   17 AB118 ILE B 107  ILE B 109  1  N  ASN B 108   O  LEU D 102           
SHEET   18 AB118 ILE F 115  ILE F 117  1  O  ASN F 116   N  ILE B 107           
SHEET    1 AB2 3 LYS C 179  PRO C 188  0                                        
SHEET    2 AB2 3 ILE C 260  SER C 269 -1  O  LEU C 261   N  LYS C 187           
SHEET    3 AB2 3 LYS C 283  ILE C 291 -1  O  PHE C 288   N  ILE C 264           
SHEET    1 AB3 4 ILE C 233  ASN C 234  0                                        
SHEET    2 AB3 4 ILE C 221  GLU C 228 -1  N  CYS C 227   O  ASN C 234           
SHEET    3 AB3 4 TRP C 236  LEU C 241 -1  O  THR C 238   N  GLU C 222           
SHEET    4 AB3 4 LYS C 320  GLN C 325 -1  O  LYS C 320   N  LEU C 241           
SHEET    1 AB4 6 ILE C 233  ASN C 234  0                                        
SHEET    2 AB4 6 ILE C 221  GLU C 228 -1  N  CYS C 227   O  ASN C 234           
SHEET    3 AB4 6 LEU C 559  LYS C 569 -1  O  LEU C 566   N  VAL C 226           
SHEET    4 AB4 6 ILE C 613  ASP C 619 -1  O  LYS C 618   N  TYR C 560           
SHEET    5 AB4 6 ILE C 523  LEU C 525 -1  N  ILE C 523   O  ILE C 617           
SHEET    6 AB4 6 GLN C 452  LEU C 454 -1  N  ILE C 453   O  LEU C 524           
SHEET    1 AB5 2 ILE C 342  LEU C 344  0                                        
SHEET    2 AB5 2 GLN C 378  PHE C 380 -1  O  ALA C 379   N  ALA C 343           
SHEET    1 AB6 2 SER C 363  ASP C 365  0                                        
SHEET    2 AB6 2 SER C 415  HIS C 417  1  O  TYR C 416   N  ASP C 365           
SHEET    1 AB7 3 LYS C 479  ASP C 481  0                                        
SHEET    2 AB7 3 PHE C 461  ILE C 468 -1  N  ASN C 467   O  GLU C 480           
SHEET    3 AB7 3 LYS C 490  LEU C 500  1  O  ASN C 499   N  LYS C 466           
SHEET    1 AB8 5 ILE C 710  PRO C 714  0                                        
SHEET    2 AB8 5 LEU C 691  GLU C 695 -1  N  ILE C 694   O  ILE C 711           
SHEET    3 AB8 5 TYR C 637  ILE C 642 -1  N  ARG C 641   O  GLU C 695           
SHEET    4 AB8 5 ILE C 734  SER C 741 -1  O  ILE C 735   N  GLY C 640           
SHEET    5 AB8 5 LYS C 744  LEU C 750 -1  O  GLU C 746   N  GLU C 738           
SHEET    1 AB9 2 ILE C 683  LEU C 684  0                                        
SHEET    2 AB9 2 SER E 752  ASN E 753 -1  O  ASN E 753   N  ILE C 683           
SHEET    1 AC1 9 GLU C 778  GLN C 783  0                                        
SHEET    2 AC1 9 GLU C 788  THR C 793 -1  O  THR C 789   N  THR C 782           
SHEET    3 AC1 9 GLU C 800  ILE C 805 -1  O  ILE C 805   N  PHE C 790           
SHEET    4 AC1 9 ILE C 811  LYS C 816 -1  O  PHE C 812   N  LEU C 804           
SHEET    5 AC1 9 ASP D   5  ILE D   7 -1  O  HIS D   6   N  TYR C 815           
SHEET    6 AC1 9 GLY D  14  LYS D  20 -1  O  LYS D  20   N  ASP D   5           
SHEET    7 AC1 9 CYS D  26  GLU D  31 -1  O  THR D  28   N  ILE D  17           
SHEET    8 AC1 9 LYS D  35  HIS D  38 -1  O  THR D  37   N  LYS D  29           
SHEET    9 AC1 9 SER B  43  SER B  46  1  N  GLU B  45   O  ILE D  36           
SHEET    1 AC2 3 LYS E 179  PRO E 188  0                                        
SHEET    2 AC2 3 ILE E 260  SER E 269 -1  O  LEU E 261   N  LYS E 187           
SHEET    3 AC2 3 LYS E 283  ILE E 291 -1  O  PHE E 288   N  ILE E 264           
SHEET    1 AC3 4 ILE E 233  ASN E 234  0                                        
SHEET    2 AC3 4 ILE E 221  GLU E 228 -1  N  CYS E 227   O  ASN E 234           
SHEET    3 AC3 4 TRP E 236  LEU E 241 -1  O  THR E 238   N  GLU E 222           
SHEET    4 AC3 4 LYS E 320  GLN E 325 -1  O  LYS E 320   N  LEU E 241           
SHEET    1 AC4 6 ILE E 233  ASN E 234  0                                        
SHEET    2 AC4 6 ILE E 221  GLU E 228 -1  N  CYS E 227   O  ASN E 234           
SHEET    3 AC4 6 LEU E 559  LYS E 569 -1  O  LEU E 566   N  VAL E 226           
SHEET    4 AC4 6 ILE E 613  ASP E 619 -1  O  LYS E 618   N  TYR E 560           
SHEET    5 AC4 6 ILE E 523  LEU E 525 -1  N  ILE E 523   O  ILE E 617           
SHEET    6 AC4 6 GLN E 452  LEU E 454 -1  N  ILE E 453   O  LEU E 524           
SHEET    1 AC5 2 ILE E 342  LEU E 344  0                                        
SHEET    2 AC5 2 GLN E 378  PHE E 380 -1  O  ALA E 379   N  ALA E 343           
SHEET    1 AC6 2 SER E 363  ASP E 365  0                                        
SHEET    2 AC6 2 SER E 415  HIS E 417  1  O  TYR E 416   N  ASP E 365           
SHEET    1 AC7 3 LYS E 479  ASP E 481  0                                        
SHEET    2 AC7 3 PHE E 461  ILE E 468 -1  N  ASN E 467   O  GLU E 480           
SHEET    3 AC7 3 LYS E 490  LEU E 500  1  O  ASN E 499   N  LYS E 466           
SHEET    1 AC8 5 ILE E 710  PRO E 714  0                                        
SHEET    2 AC8 5 LEU E 691  GLU E 695 -1  N  ILE E 694   O  ILE E 711           
SHEET    3 AC8 5 TYR E 637  ILE E 642 -1  N  ARG E 641   O  GLU E 695           
SHEET    4 AC8 5 ILE E 734  SER E 741 -1  O  ILE E 735   N  GLY E 640           
SHEET    5 AC8 5 LYS E 744  LEU E 750 -1  O  GLU E 746   N  GLU E 738           
SHEET    1 AC918 GLU E 778  GLN E 783  0                                        
SHEET    2 AC918 GLU E 788  THR E 793 -1  O  THR E 789   N  THR E 782           
SHEET    3 AC918 GLU E 800  ILE E 805 -1  O  ILE E 805   N  PHE E 790           
SHEET    4 AC918 ILE E 811  LYS E 816 -1  O  PHE E 812   N  LEU E 804           
SHEET    5 AC918 ASP F   5  ILE F   7 -1  O  HIS F   6   N  TYR E 815           
SHEET    6 AC918 GLY F  14  LYS F  20 -1  O  LYS F  20   N  ASP F   5           
SHEET    7 AC918 CYS F  26  GLU F  31 -1  O  THR F  28   N  ILE F  17           
SHEET    8 AC918 ILE F  36  HIS F  38 -1  O  THR F  37   N  LYS F  29           
SHEET    9 AC918 SER D  43  SER D  46  1  N  GLU D  45   O  ILE F  36           
SHEET   10 AC918 GLN B  51  ILE B  53  1  N  ILE B  53   O  SER D  46           
SHEET   11 AC918 ILE B  61  ILE B  63 -1  O  ILE B  63   N  ILE B  52           
SHEET   12 AC918 ILE B  68  THR B  72 -1  O  LEU B  69   N  SER B  62           
SHEET   13 AC918 SER B  75  SER B  80 -1  O  SER B  75   N  THR B  72           
SHEET   14 AC918 LYS B  83  ILE B  88 -1  O  VAL B  85   N  MET B  78           
SHEET   15 AC918 SER B  91  LEU B  95 -1  O  SER B  91   N  ILE B  88           
SHEET   16 AC918 ILE B 100  SER B 104 -1  O  GLU B 103   N  LEU B  92           
SHEET   17 AC918 ILE F 107  ILE F 109  1  O  ASN F 108   N  LEU B 102           
SHEET   18 AC918 ILE D 115  ILE D 117  1  N  ASN D 116   O  ILE F 107           
SHEET    1 AD110 ILE F  52  ILE F  53  0                                        
SHEET    2 AD110 ILE F  61  ILE F  63 -1  O  ILE F  63   N  ILE F  52           
SHEET    3 AD110 ILE F  68  THR F  72 -1  O  LEU F  69   N  SER F  62           
SHEET    4 AD110 SER F  75  SER F  80 -1  O  SER F  75   N  THR F  72           
SHEET    5 AD110 LYS F  83  ILE F  88 -1  O  VAL F  85   N  MET F  78           
SHEET    6 AD110 SER F  91  LEU F  95 -1  O  SER F  91   N  ILE F  88           
SHEET    7 AD110 ILE F 100  SER F 104 -1  O  GLU F 103   N  LEU F  92           
SHEET    8 AD110 ILE D 107  ILE D 109  1  N  ASN D 108   O  LEU F 102           
SHEET    9 AD110 ILE B 115  ILE B 117  1  N  ASN B 116   O  ILE D 107           
SHEET   10 AD110 ASP F 124  ILE F 125  1  N  ASP F 124   O  ILE B 115           
CISPEP   1 ASN A  175    VAL A  176          0         5.60                     
CISPEP   2 ALA A  242    TYR A  243          0         8.88                     
CISPEP   3 ILE A  244    ASN A  245          0        -2.60                     
CISPEP   4 LYS A  410    SER A  411          0       -11.25                     
CISPEP   5 ASN A  510    ASP A  511          0        -4.02                     
CISPEP   6 LYS A  678    GLY A  679          0       -20.18                     
CISPEP   7 ASN C  175    VAL C  176          0         5.72                     
CISPEP   8 ALA C  242    TYR C  243          0         8.86                     
CISPEP   9 ILE C  244    ASN C  245          0        -2.65                     
CISPEP  10 LYS C  410    SER C  411          0       -11.27                     
CISPEP  11 ASN C  510    ASP C  511          0        -4.06                     
CISPEP  12 LYS C  678    GLY C  679          0       -20.22                     
CISPEP  13 ASN E  175    VAL E  176          0         5.63                     
CISPEP  14 ALA E  242    TYR E  243          0         8.81                     
CISPEP  15 ILE E  244    ASN E  245          0        -2.54                     
CISPEP  16 LYS E  410    SER E  411          0       -11.25                     
CISPEP  17 ASN E  510    ASP E  511          0        -3.99                     
CISPEP  18 LYS E  678    GLY E  679          0       -20.15                     
CISPEP  19 GLY B   89    ASN B   90          0         2.28                     
CISPEP  20 GLY D   89    ASN D   90          0         2.17                     
CISPEP  21 GLY F   89    ASN F   90          0         2.33                     
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1                      
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      1.000000  0.000000  0.000000        0.00000                         
SCALE2      0.000000  1.000000  0.000000        0.00000                         
SCALE3      0.000000  0.000000  1.000000        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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