GenomeNet

Database: PDB
Entry: 6UGM
LinkDB: 6UGM
Original site: 6UGM 
HEADER    TRANSFERASE/STRUCTURAL PROTEIN/DNA      26-SEP-19   6UGM              
TITLE     STRUCTURAL BASIS OF COMPASS ECM RECOGNITION OF AN UNMODIFIED          
TITLE    2 NUCLEOSOME                                                           
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: HISTONE H3;                                                
COMPND   3 CHAIN: A, E;                                                         
COMPND   4 ENGINEERED: YES;                                                     
COMPND   5 MOL_ID: 2;                                                           
COMPND   6 MOLECULE: HISTONE H4;                                                
COMPND   7 CHAIN: B, F;                                                         
COMPND   8 ENGINEERED: YES;                                                     
COMPND   9 MOL_ID: 3;                                                           
COMPND  10 MOLECULE: HISTONE H2A;                                               
COMPND  11 CHAIN: C, G;                                                         
COMPND  12 ENGINEERED: YES;                                                     
COMPND  13 MOL_ID: 4;                                                           
COMPND  14 MOLECULE: HISTONE H2B;                                               
COMPND  15 CHAIN: D;                                                            
COMPND  16 ENGINEERED: YES;                                                     
COMPND  17 MOL_ID: 5;                                                           
COMPND  18 MOLECULE: HISTONE H2B 1.1;                                           
COMPND  19 CHAIN: H;                                                            
COMPND  20 SYNONYM: H2B1.1;                                                     
COMPND  21 ENGINEERED: YES;                                                     
COMPND  22 MOL_ID: 6;                                                           
COMPND  23 MOLECULE: DNA (146-MER);                                             
COMPND  24 CHAIN: I;                                                            
COMPND  25 ENGINEERED: YES;                                                     
COMPND  26 MOL_ID: 7;                                                           
COMPND  27 MOLECULE: DNA (146-MER);                                             
COMPND  28 CHAIN: J;                                                            
COMPND  29 ENGINEERED: YES;                                                     
COMPND  30 MOL_ID: 8;                                                           
COMPND  31 MOLECULE: SWD3;                                                      
COMPND  32 CHAIN: K;                                                            
COMPND  33 ENGINEERED: YES;                                                     
COMPND  34 MOL_ID: 9;                                                           
COMPND  35 MOLECULE: HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-4 SPECIFIC;  
COMPND  36 CHAIN: M;                                                            
COMPND  37 SYNONYM: COMPASS COMPONENT SET1,SET DOMAIN-CONTAINING PROTEIN 1;     
COMPND  38 EC: 2.1.1.43;                                                        
COMPND  39 ENGINEERED: YES;                                                     
COMPND  40 MOL_ID: 10;                                                          
COMPND  41 MOLECULE: SWD1;                                                      
COMPND  42 CHAIN: N;                                                            
COMPND  43 ENGINEERED: YES;                                                     
COMPND  44 MOL_ID: 11;                                                          
COMPND  45 MOLECULE: H3 N-TERMINUS;                                             
COMPND  46 CHAIN: R;                                                            
COMPND  47 ENGINEERED: YES;                                                     
COMPND  48 MOL_ID: 12;                                                          
COMPND  49 MOLECULE: SPP1;                                                      
COMPND  50 CHAIN: X;                                                            
COMPND  51 ENGINEERED: YES;                                                     
COMPND  52 MOL_ID: 13;                                                          
COMPND  53 MOLECULE: BRE2;                                                      
COMPND  54 CHAIN: L;                                                            
COMPND  55 ENGINEERED: YES;                                                     
COMPND  56 MOL_ID: 14;                                                          
COMPND  57 MOLECULE: SDC1;                                                      
COMPND  58 CHAIN: O, P;                                                         
COMPND  59 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: XENOPUS LAEVIS;                                 
SOURCE   3 ORGANISM_COMMON: AFRICAN CLAWED FROG;                                
SOURCE   4 ORGANISM_TAXID: 8355;                                                
SOURCE   5 GENE: HIST1H3G, H3L;                                                 
SOURCE   6 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE   7 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE   8 MOL_ID: 2;                                                           
SOURCE   9 ORGANISM_SCIENTIFIC: XENOPUS LAEVIS;                                 
SOURCE  10 ORGANISM_COMMON: AFRICAN CLAWED FROG;                                
SOURCE  11 ORGANISM_TAXID: 8355;                                                
SOURCE  12 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  13 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE  14 MOL_ID: 3;                                                           
SOURCE  15 ORGANISM_SCIENTIFIC: XENOPUS LAEVIS;                                 
SOURCE  16 ORGANISM_COMMON: AFRICAN CLAWED FROG;                                
SOURCE  17 ORGANISM_TAXID: 8355;                                                
SOURCE  18 GENE: HIST1H2AJ, LOC494591, XELAEV_18003602MG;                       
SOURCE  19 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  20 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE  21 MOL_ID: 4;                                                           
SOURCE  22 ORGANISM_SCIENTIFIC: XENOPUS LAEVIS;                                 
SOURCE  23 ORGANISM_COMMON: AFRICAN CLAWED FROG;                                
SOURCE  24 ORGANISM_TAXID: 8355;                                                
SOURCE  25 GENE: XELAEV_18032686MG;                                             
SOURCE  26 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  27 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE  28 MOL_ID: 5;                                                           
SOURCE  29 ORGANISM_SCIENTIFIC: XENOPUS LAEVIS;                                 
SOURCE  30 ORGANISM_COMMON: AFRICAN CLAWED FROG;                                
SOURCE  31 ORGANISM_TAXID: 8355;                                                
SOURCE  32 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  33 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE  34 MOL_ID: 6;                                                           
SOURCE  35 SYNTHETIC: YES;                                                      
SOURCE  36 ORGANISM_SCIENTIFIC: SYNTHETIC CONSTRUCT;                            
SOURCE  37 ORGANISM_TAXID: 32630;                                               
SOURCE  38 MOL_ID: 7;                                                           
SOURCE  39 SYNTHETIC: YES;                                                      
SOURCE  40 ORGANISM_SCIENTIFIC: SYNTHETIC CONSTRUCT;                            
SOURCE  41 ORGANISM_TAXID: 32630;                                               
SOURCE  42 MOL_ID: 8;                                                           
SOURCE  43 ORGANISM_SCIENTIFIC: KLUYVEROMYCES LACTIS (STRAIN ATCC 8585 / CBS    
SOURCE  44 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37);                  
SOURCE  45 ORGANISM_COMMON: YEAST;                                              
SOURCE  46 ORGANISM_TAXID: 284590;                                              
SOURCE  47 STRAIN: ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / 
SOURCE  48 WM37;                                                                
SOURCE  49 GENE: KLLA0_E24487G;                                                 
SOURCE  50 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;                                  
SOURCE  51 EXPRESSION_SYSTEM_COMMON: CABBAGE LOOPER;                            
SOURCE  52 EXPRESSION_SYSTEM_TAXID: 7111;                                       
SOURCE  53 MOL_ID: 9;                                                           
SOURCE  54 ORGANISM_SCIENTIFIC: KLUYVEROMYCES LACTIS (STRAIN ATCC 8585 / CBS    
SOURCE  55 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37);                  
SOURCE  56 ORGANISM_COMMON: YEAST;                                              
SOURCE  57 ORGANISM_TAXID: 284590;                                              
SOURCE  58 STRAIN: ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / 
SOURCE  59 WM37;                                                                
SOURCE  60 GENE: SET1, KLLA0F24134G;                                            
SOURCE  61 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;                                  
SOURCE  62 EXPRESSION_SYSTEM_COMMON: CABBAGE LOOPER;                            
SOURCE  63 EXPRESSION_SYSTEM_TAXID: 7111;                                       
SOURCE  64 MOL_ID: 10;                                                          
SOURCE  65 ORGANISM_SCIENTIFIC: KLUYVEROMYCES LACTIS (STRAIN ATCC 8585 / CBS    
SOURCE  66 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37);                  
SOURCE  67 ORGANISM_COMMON: YEAST;                                              
SOURCE  68 ORGANISM_TAXID: 284590;                                              
SOURCE  69 STRAIN: ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / 
SOURCE  70 WM37;                                                                
SOURCE  71 GENE: KLLA0_A08800G;                                                 
SOURCE  72 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;                                  
SOURCE  73 EXPRESSION_SYSTEM_COMMON: CABBAGE LOOPER;                            
SOURCE  74 EXPRESSION_SYSTEM_TAXID: 7111;                                       
SOURCE  75 MOL_ID: 11;                                                          
SOURCE  76 ORGANISM_SCIENTIFIC: XENOPUS LAEVIS;                                 
SOURCE  77 ORGANISM_COMMON: AFRICAN CLAWED FROG;                                
SOURCE  78 ORGANISM_TAXID: 8355;                                                
SOURCE  79 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  80 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE  81 MOL_ID: 12;                                                          
SOURCE  82 ORGANISM_SCIENTIFIC: KLUYVEROMYCES LACTIS (STRAIN ATCC 8585 / CBS    
SOURCE  83 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37);                  
SOURCE  84 ORGANISM_COMMON: YEAST;                                              
SOURCE  85 ORGANISM_TAXID: 284590;                                              
SOURCE  86 STRAIN: ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / 
SOURCE  87 WM37;                                                                
SOURCE  88 GENE: KLLA0_D07260G;                                                 
SOURCE  89 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;                                  
SOURCE  90 EXPRESSION_SYSTEM_COMMON: CABBAGE LOOPER;                            
SOURCE  91 EXPRESSION_SYSTEM_TAXID: 7111;                                       
SOURCE  92 MOL_ID: 13;                                                          
SOURCE  93 ORGANISM_SCIENTIFIC: KLUYVEROMYCES LACTIS (STRAIN ATCC 8585 / CBS    
SOURCE  94 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37);                  
SOURCE  95 ORGANISM_COMMON: YEAST;                                              
SOURCE  96 ORGANISM_TAXID: 284590;                                              
SOURCE  97 STRAIN: ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / 
SOURCE  98 WM37;                                                                
SOURCE  99 GENE: KLLA0_C10945G;                                                 
SOURCE 100 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;                                  
SOURCE 101 EXPRESSION_SYSTEM_COMMON: CABBAGE LOOPER;                            
SOURCE 102 EXPRESSION_SYSTEM_TAXID: 7111;                                       
SOURCE 103 MOL_ID: 14;                                                          
SOURCE 104 ORGANISM_SCIENTIFIC: KLUYVEROMYCES LACTIS (STRAIN ATCC 8585 / CBS    
SOURCE 105 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37);                  
SOURCE 106 ORGANISM_COMMON: YEAST;                                              
SOURCE 107 ORGANISM_TAXID: 284590;                                              
SOURCE 108 STRAIN: ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / 
SOURCE 109 WM37;                                                                
SOURCE 110 GENE: KLLA0_E03521G;                                                 
SOURCE 111 EXPRESSION_SYSTEM: TRICHOPLUSIA NI;                                  
SOURCE 112 EXPRESSION_SYSTEM_COMMON: CABBAGE LOOPER;                            
SOURCE 113 EXPRESSION_SYSTEM_TAXID: 7111                                        
KEYWDS    COMPLEX, METHYLTRANSFERASE, EPIGENETICS, CHROMATIN, NUCLEOSOME,       
KEYWDS   2 TRANSFERASE-STRUCTURAL PROTEIN-DNA COMPLEX                           
EXPDTA    ELECTRON MICROSCOPY                                                   
AUTHOR    P.L.HSU,H.SHI,N.ZHENG                                                 
REVDAT   4   20-MAR-24 6UGM    1       REMARK                                   
REVDAT   3   18-DEC-19 6UGM    1       JRNL                                     
REVDAT   2   27-NOV-19 6UGM    1       JRNL                                     
REVDAT   1   20-NOV-19 6UGM    0                                                
JRNL        AUTH   P.L.HSU,H.SHI,C.LEONEN,J.KANG,C.CHATTERJEE,N.ZHENG           
JRNL        TITL   STRUCTURAL BASIS OF H2B UBIQUITINATION-DEPENDENT H3K4        
JRNL        TITL 2 METHYLATION BY COMPASS.                                      
JRNL        REF    MOL.CELL                      V.  76   712 2019              
JRNL        REFN                   ISSN 1097-2765                               
JRNL        PMID   31733991                                                     
JRNL        DOI    10.1016/J.MOLCEL.2019.10.013                                 
REMARK   2                                                                      
REMARK   2 RESOLUTION.    3.70 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   SOFTWARE PACKAGES      : NULL                                      
REMARK   3   RECONSTRUCTION SCHEMA  : NULL                                      
REMARK   3                                                                      
REMARK   3 EM MAP-MODEL FITTING AND REFINEMENT                                  
REMARK   3   PDB ENTRY                    : NULL                                
REMARK   3   REFINEMENT SPACE             : NULL                                
REMARK   3   REFINEMENT PROTOCOL          : NULL                                
REMARK   3   REFINEMENT TARGET            : NULL                                
REMARK   3   OVERALL ANISOTROPIC B VALUE  : NULL                                
REMARK   3                                                                      
REMARK   3 FITTING PROCEDURE : NULL                                             
REMARK   3                                                                      
REMARK   3 EM IMAGE RECONSTRUCTION STATISTICS                                   
REMARK   3   NOMINAL PIXEL SIZE (ANGSTROMS)    : NULL                           
REMARK   3   ACTUAL PIXEL SIZE  (ANGSTROMS)    : NULL                           
REMARK   3   EFFECTIVE RESOLUTION (ANGSTROMS)  : 3.700                          
REMARK   3   NUMBER OF PARTICLES               : 100905                         
REMARK   3   CTF CORRECTION METHOD             : PHASE FLIPPING AND AMPLITUDE   
REMARK   3                                       CORRECTION                     
REMARK   3                                                                      
REMARK   3 EM RECONSTRUCTION MAGNIFICATION CALIBRATION: NULL                    
REMARK   3                                                                      
REMARK   3 OTHER DETAILS: NULL                                                  
REMARK   4                                                                      
REMARK   4 6UGM COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY RCSB ON 27-SEP-19.                  
REMARK 100 THE DEPOSITION ID IS D_1000243234.                                   
REMARK 245                                                                      
REMARK 245 EXPERIMENTAL DETAILS                                                 
REMARK 245   RECONSTRUCTION METHOD          : SINGLE PARTICLE                   
REMARK 245   SPECIMEN TYPE                  : NULL                              
REMARK 245                                                                      
REMARK 245 ELECTRON MICROSCOPE SAMPLE                                           
REMARK 245   SAMPLE TYPE                    : PARTICLE                          
REMARK 245   PARTICLE TYPE                  : POINT                             
REMARK 245   NAME OF SAMPLE                 : YEAST COMPASS ECM BOUND TO AN     
REMARK 245                                    UNMODIFIED NUCLEOSOME;            
REMARK 245                                    NUCLEOSOME; COMPASS ECM           
REMARK 245   SAMPLE CONCENTRATION (MG ML-1) : NULL                              
REMARK 245   SAMPLE SUPPORT DETAILS         : UNSPECIFIED                       
REMARK 245   SAMPLE VITRIFICATION DETAILS   : NULL                              
REMARK 245   SAMPLE BUFFER                  : NULL                              
REMARK 245   PH                             : 7.50                              
REMARK 245   SAMPLE DETAILS                 : NULL                              
REMARK 245                                                                      
REMARK 245 DATA ACQUISITION                                                     
REMARK 245   DATE OF EXPERIMENT                : NULL                           
REMARK 245   NUMBER OF MICROGRAPHS-IMAGES      : NULL                           
REMARK 245   TEMPERATURE (KELVIN)              : NULL                           
REMARK 245   MICROSCOPE MODEL                  : FEI TITAN KRIOS                
REMARK 245   DETECTOR TYPE                     : GATAN K2 SUMMIT (4K X 4K)      
REMARK 245   MINIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MAXIMUM DEFOCUS (NM)              : NULL                           
REMARK 245   MINIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   MAXIMUM TILT ANGLE (DEGREES)      : NULL                           
REMARK 245   NOMINAL CS                        : NULL                           
REMARK 245   IMAGING MODE                      : BRIGHT FIELD                   
REMARK 245   ELECTRON DOSE (ELECTRONS NM**-2)  : 7400.00                        
REMARK 245   ILLUMINATION MODE                 : FLOOD BEAM                     
REMARK 245   NOMINAL MAGNIFICATION             : NULL                           
REMARK 245   CALIBRATED MAGNIFICATION          : NULL                           
REMARK 245   SOURCE                            : FIELD EMISSION GUN             
REMARK 245   ACCELERATION VOLTAGE (KV)         : 300                            
REMARK 245   IMAGING DETAILS                   : NULL                           
REMARK 247                                                                      
REMARK 247 ELECTRON MICROSCOPY                                                  
REMARK 247  THE COORDINATES IN THIS ENTRY WERE GENERATED FROM ELECTRON          
REMARK 247  MICROSCOPY DATA. PROTEIN DATA BANK CONVENTIONS REQUIRE              
REMARK 247  THAT CRYST1 AND SCALE RECORDS BE INCLUDED, BUT THE VALUES           
REMARK 247  ON THESE RECORDS ARE MEANINGLESS EXCEPT FOR THE CALCULATION         
REMARK 247  OF THE STRUCTURE FACTORS.                                           
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1                                                       
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: OCTADECAMERIC                     
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B, C, D, E, F, G, H, I, J,         
REMARK 350                    AND CHAINS: K, M, N, R, X, L, O, P                
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     ALA A     1                                                      
REMARK 465     ARG A     2                                                      
REMARK 465     THR A     3                                                      
REMARK 465     LYS A     4                                                      
REMARK 465     GLN A     5                                                      
REMARK 465     THR A     6                                                      
REMARK 465     ALA A     7                                                      
REMARK 465     ARG A     8                                                      
REMARK 465     LYS A     9                                                      
REMARK 465     SER A    10                                                      
REMARK 465     THR A    11                                                      
REMARK 465     GLY A    12                                                      
REMARK 465     GLY A    13                                                      
REMARK 465     LYS A    14                                                      
REMARK 465     ALA A    15                                                      
REMARK 465     PRO A    16                                                      
REMARK 465     ARG A    17                                                      
REMARK 465     LYS A    18                                                      
REMARK 465     GLN A    19                                                      
REMARK 465     LEU A    20                                                      
REMARK 465     ALA A    21                                                      
REMARK 465     THR A    22                                                      
REMARK 465     LYS A    23                                                      
REMARK 465     ALA A    24                                                      
REMARK 465     ALA A    25                                                      
REMARK 465     ARG A    26                                                      
REMARK 465     LYS A    27                                                      
REMARK 465     SER A    28                                                      
REMARK 465     ALA A    29                                                      
REMARK 465     PRO A    30                                                      
REMARK 465     ALA A    31                                                      
REMARK 465     THR A    32                                                      
REMARK 465     GLY A    33                                                      
REMARK 465     GLY A    34                                                      
REMARK 465     VAL A    35                                                      
REMARK 465     LYS A    36                                                      
REMARK 465     LYS A    37                                                      
REMARK 465     ALA A   135                                                      
REMARK 465     SER B     1                                                      
REMARK 465     GLY B     2                                                      
REMARK 465     ARG B     3                                                      
REMARK 465     GLY B     4                                                      
REMARK 465     LYS B     5                                                      
REMARK 465     GLY B     6                                                      
REMARK 465     GLY B     7                                                      
REMARK 465     LYS B     8                                                      
REMARK 465     GLY B     9                                                      
REMARK 465     LEU B    10                                                      
REMARK 465     GLY B    11                                                      
REMARK 465     LYS B    12                                                      
REMARK 465     GLY B    13                                                      
REMARK 465     GLY B    14                                                      
REMARK 465     ALA B    15                                                      
REMARK 465     LYS B    16                                                      
REMARK 465     ARG B    17                                                      
REMARK 465     HIS B    18                                                      
REMARK 465     ARG B    19                                                      
REMARK 465     GLY B   102                                                      
REMARK 465     PRO D    -2                                                      
REMARK 465     GLU D    -1                                                      
REMARK 465     PRO D     0                                                      
REMARK 465     ALA D     1                                                      
REMARK 465     LYS D     2                                                      
REMARK 465     SER D     3                                                      
REMARK 465     ALA D     4                                                      
REMARK 465     PRO D     5                                                      
REMARK 465     ALA D     6                                                      
REMARK 465     PRO D     7                                                      
REMARK 465     LYS D     8                                                      
REMARK 465     LYS D     9                                                      
REMARK 465     GLY D    10                                                      
REMARK 465     SER D    11                                                      
REMARK 465     LYS D    12                                                      
REMARK 465     LYS D    13                                                      
REMARK 465     ALA D    14                                                      
REMARK 465     VAL D    15                                                      
REMARK 465     THR D    16                                                      
REMARK 465     LYS D    17                                                      
REMARK 465     THR D    18                                                      
REMARK 465     GLN D    19                                                      
REMARK 465     LYS D    20                                                      
REMARK 465     LYS D    21                                                      
REMARK 465     ASP D    22                                                      
REMARK 465     GLY D    23                                                      
REMARK 465     LYS D    24                                                      
REMARK 465     LYS D    25                                                      
REMARK 465     ARG D    26                                                      
REMARK 465     ARG D    27                                                      
REMARK 465     LYS D    28                                                      
REMARK 465     LYS D   122                                                      
REMARK 465     ALA E     1                                                      
REMARK 465     ARG E     2                                                      
REMARK 465     THR E     3                                                      
REMARK 465     LYS E     4                                                      
REMARK 465     GLN E     5                                                      
REMARK 465     THR E     6                                                      
REMARK 465     ALA E     7                                                      
REMARK 465     ARG E     8                                                      
REMARK 465     LYS E     9                                                      
REMARK 465     SER E    10                                                      
REMARK 465     THR E    11                                                      
REMARK 465     GLY E    12                                                      
REMARK 465     GLY E    13                                                      
REMARK 465     LYS E    14                                                      
REMARK 465     ALA E    15                                                      
REMARK 465     PRO E    16                                                      
REMARK 465     ARG E    17                                                      
REMARK 465     LYS E    18                                                      
REMARK 465     GLN E    19                                                      
REMARK 465     LEU E    20                                                      
REMARK 465     ALA E    21                                                      
REMARK 465     THR E    22                                                      
REMARK 465     LYS E    23                                                      
REMARK 465     ALA E    24                                                      
REMARK 465     ALA E    25                                                      
REMARK 465     ARG E    26                                                      
REMARK 465     LYS E    27                                                      
REMARK 465     SER E    28                                                      
REMARK 465     ALA E    29                                                      
REMARK 465     PRO E    30                                                      
REMARK 465     ALA E    31                                                      
REMARK 465     THR E    32                                                      
REMARK 465     GLY E    33                                                      
REMARK 465     GLY E    34                                                      
REMARK 465     VAL E    35                                                      
REMARK 465     LYS E    36                                                      
REMARK 465     LYS E    37                                                      
REMARK 465     PRO E    38                                                      
REMARK 465     ALA E   135                                                      
REMARK 465     SER F     1                                                      
REMARK 465     GLY F     2                                                      
REMARK 465     ARG F     3                                                      
REMARK 465     GLY F     4                                                      
REMARK 465     LYS F     5                                                      
REMARK 465     GLY F     6                                                      
REMARK 465     GLY F     7                                                      
REMARK 465     LYS F     8                                                      
REMARK 465     GLY F     9                                                      
REMARK 465     LEU F    10                                                      
REMARK 465     GLY F    11                                                      
REMARK 465     LYS F    12                                                      
REMARK 465     GLY F    13                                                      
REMARK 465     GLY F    14                                                      
REMARK 465     ALA F    15                                                      
REMARK 465     LYS F    16                                                      
REMARK 465     PRO H    -2                                                      
REMARK 465     GLU H    -1                                                      
REMARK 465     PRO H     0                                                      
REMARK 465     ALA H     1                                                      
REMARK 465     LYS H     2                                                      
REMARK 465     SER H     3                                                      
REMARK 465     ALA H     4                                                      
REMARK 465     PRO H     5                                                      
REMARK 465     ALA H     6                                                      
REMARK 465     PRO H     7                                                      
REMARK 465     LYS H     8                                                      
REMARK 465     LYS H     9                                                      
REMARK 465     GLY H    10                                                      
REMARK 465     SER H    11                                                      
REMARK 465     LYS H    12                                                      
REMARK 465     LYS H    13                                                      
REMARK 465     ALA H    14                                                      
REMARK 465     VAL H    15                                                      
REMARK 465     THR H    16                                                      
REMARK 465     LYS H    17                                                      
REMARK 465     THR H    18                                                      
REMARK 465     GLN H    19                                                      
REMARK 465     LYS H    20                                                      
REMARK 465     LYS H    21                                                      
REMARK 465     ASP H    22                                                      
REMARK 465     GLY H    23                                                      
REMARK 465     LYS H    24                                                      
REMARK 465     LYS H    25                                                      
REMARK 465     ARG H    26                                                      
REMARK 465     ARG H    27                                                      
REMARK 465     LYS H    28                                                      
REMARK 465     LYS H   122                                                      
REMARK 465      DC I     1                                                      
REMARK 465     MET K     1                                                      
REMARK 465     CYS K     2                                                      
REMARK 465     ASP K     3                                                      
REMARK 465     LEU K     4                                                      
REMARK 465     ASP K     5                                                      
REMARK 465     SER K     6                                                      
REMARK 465     VAL K     7                                                      
REMARK 465     SER K     8                                                      
REMARK 465     ASP K     9                                                      
REMARK 465     LEU K    10                                                      
REMARK 465     THR K    11                                                      
REMARK 465     LEU K    12                                                      
REMARK 465     THR K    13                                                      
REMARK 465     LEU K    14                                                      
REMARK 465     ARG K    15                                                      
REMARK 465     HIS K   245                                                      
REMARK 465     GLN K   246                                                      
REMARK 465     GLU K   247                                                      
REMARK 465     THR K   248                                                      
REMARK 465     LYS K   249                                                      
REMARK 465     ALA K   250                                                      
REMARK 465     HIS K   327                                                      
REMARK 465     TYR M   774                                                      
REMARK 465     LEU M   775                                                      
REMARK 465     LEU M   776                                                      
REMARK 465     HIS M   777                                                      
REMARK 465     HIS M   778                                                      
REMARK 465     ARG M   779                                                      
REMARK 465     ARG M   780                                                      
REMARK 465     LEU M   781                                                      
REMARK 465     ALA M   782                                                      
REMARK 465     GLN M   783                                                      
REMARK 465     PRO M   784                                                      
REMARK 465     LEU M   785                                                      
REMARK 465     ASN M   786                                                      
REMARK 465     THR M   787                                                      
REMARK 465     VAL M   788                                                      
REMARK 465     HIS M   789                                                      
REMARK 465     ASN M   790                                                      
REMARK 465     HIS M   791                                                      
REMARK 465     GLN M   792                                                      
REMARK 465     GLU M   793                                                      
REMARK 465     GLN M   794                                                      
REMARK 465     ASN M   795                                                      
REMARK 465     PHE M   796                                                      
REMARK 465     MET M   797                                                      
REMARK 465     ALA M   798                                                      
REMARK 465     LEU M   799                                                      
REMARK 465     ASN M   800                                                      
REMARK 465     GLY M   801                                                      
REMARK 465     THR M   802                                                      
REMARK 465     GLU M   803                                                      
REMARK 465     SER M   804                                                      
REMARK 465     THR M   805                                                      
REMARK 465     ASN M   806                                                      
REMARK 465     GLN M   807                                                      
REMARK 465     GLU M   808                                                      
REMARK 465     ALA M   809                                                      
REMARK 465     ASP M   810                                                      
REMARK 465     LEU M   811                                                      
REMARK 465     GLU M   812                                                      
REMARK 465     GLN M   813                                                      
REMARK 465     ASP M   814                                                      
REMARK 465     ASN M   815                                                      
REMARK 465     HIS M   816                                                      
REMARK 465     ASN M   817                                                      
REMARK 465     ALA M   818                                                      
REMARK 465     SER M   819                                                      
REMARK 465     SER M   820                                                      
REMARK 465     ARG M   821                                                      
REMARK 465     LEU M   822                                                      
REMARK 465     ASN M   823                                                      
REMARK 465     ARG M   824                                                      
REMARK 465     VAL M   825                                                      
REMARK 465     PHE M   826                                                      
REMARK 465     GLN M   827                                                      
REMARK 465     ARG M   828                                                      
REMARK 465     ARG M   829                                                      
REMARK 465     PHE M   830                                                      
REMARK 465     GLN M   831                                                      
REMARK 465     GLN M   832                                                      
REMARK 465     ASP M   833                                                      
REMARK 465     ILE M   834                                                      
REMARK 465     GLU M   835                                                      
REMARK 465     ALA M   836                                                      
REMARK 465     GLN M   837                                                      
REMARK 465     ARG M   838                                                      
REMARK 465     ALA M   839                                                      
REMARK 465     ALA M   840                                                      
REMARK 465     ILE M   841                                                      
REMARK 465     GLY M   842                                                      
REMARK 465     PHE M   843                                                      
REMARK 465     GLU M   844                                                      
REMARK 465     SER M   845                                                      
REMARK 465     ASP M   846                                                      
REMARK 465     LEU M   847                                                      
REMARK 465     LEU M   848                                                      
REMARK 465     SER M   849                                                      
REMARK 465     LEU M   850                                                      
REMARK 465     GLU M   977                                                      
REMARK 465     ARG M   978                                                      
REMARK 465     GLU M   979                                                      
REMARK 465     THR M   980                                                      
REMARK 465     ASP M   981                                                      
REMARK 465     GLU M   982                                                      
REMARK 465     GLY M   983                                                      
REMARK 465     GLU M   984                                                      
REMARK 465     ARG M   985                                                      
REMARK 465     LEU M   986                                                      
REMARK 465     MET N     1                                                      
REMARK 465     GLU N   199                                                      
REMARK 465     SER N   200                                                      
REMARK 465     GLY N   201                                                      
REMARK 465     PHE N   202                                                      
REMARK 465     ASP N   249                                                      
REMARK 465     ASN N   250                                                      
REMARK 465     GLU N   251                                                      
REMARK 465     SER N   252                                                      
REMARK 465     GLU N   253                                                      
REMARK 465     GLY N   254                                                      
REMARK 465     GLY N   255                                                      
REMARK 465     SER N   256                                                      
REMARK 465     SER N   257                                                      
REMARK 465     MET N   382                                                      
REMARK 465     ASP N   383                                                      
REMARK 465     ASP N   384                                                      
REMARK 465     ASP N   385                                                      
REMARK 465     ASN N   386                                                      
REMARK 465     ASN N   387                                                      
REMARK 465     LEU N   388                                                      
REMARK 465     GLN N   389                                                      
REMARK 465     ALA N   390                                                      
REMARK 465     MET N   391                                                      
REMARK 465     THR N   392                                                      
REMARK 465     GLU N   393                                                      
REMARK 465     ALA N   394                                                      
REMARK 465     HIS N   436                                                      
REMARK 465     GLN N   437                                                      
REMARK 465     GLU N   438                                                      
REMARK 465     GLN N   439                                                      
REMARK 465     MET X     1                                                      
REMARK 465     SER X     2                                                      
REMARK 465     LEU X     3                                                      
REMARK 465     PRO X     4                                                      
REMARK 465     SER X     5                                                      
REMARK 465     TRP X     6                                                      
REMARK 465     CYS X     7                                                      
REMARK 465     PRO X     8                                                      
REMARK 465     ARG X     9                                                      
REMARK 465     TYR X    10                                                      
REMARK 465     ASP X    11                                                      
REMARK 465     SER X    12                                                      
REMARK 465     ARG X    13                                                      
REMARK 465     LYS X    14                                                      
REMARK 465     HIS X    15                                                      
REMARK 465     ASP X    16                                                      
REMARK 465     PRO X    17                                                      
REMARK 465     LYS X    18                                                      
REMARK 465     THR X    19                                                      
REMARK 465     GLY X    20                                                      
REMARK 465     GLU X    21                                                      
REMARK 465     GLU X    22                                                      
REMARK 465     VAL X    23                                                      
REMARK 465     TYR X    24                                                      
REMARK 465     CYS X    25                                                      
REMARK 465     ILE X    26                                                      
REMARK 465     CYS X    27                                                      
REMARK 465     LYS X    28                                                      
REMARK 465     LYS X    29                                                      
REMARK 465     PRO X    30                                                      
REMARK 465     ASP X    31                                                      
REMARK 465     THR X    32                                                      
REMARK 465     GLY X    33                                                      
REMARK 465     GLU X    34                                                      
REMARK 465     LEU X    35                                                      
REMARK 465     MET X    36                                                      
REMARK 465     VAL X    37                                                      
REMARK 465     GLY X    38                                                      
REMARK 465     CYS X    39                                                      
REMARK 465     ASP X    40                                                      
REMARK 465     GLY X    41                                                      
REMARK 465     CYS X    42                                                      
REMARK 465     ASP X    43                                                      
REMARK 465     ASP X    44                                                      
REMARK 465     TRP X    45                                                      
REMARK 465     PHE X    46                                                      
REMARK 465     HIS X    47                                                      
REMARK 465     PHE X    48                                                      
REMARK 465     SER X    49                                                      
REMARK 465     CYS X    50                                                      
REMARK 465     LEU X    51                                                      
REMARK 465     LYS X    52                                                      
REMARK 465     ILE X    53                                                      
REMARK 465     PRO X    54                                                      
REMARK 465     GLU X    55                                                      
REMARK 465     LYS X    56                                                      
REMARK 465     TYR X    57                                                      
REMARK 465     ARG X    58                                                      
REMARK 465     ASP X    59                                                      
REMARK 465     LEU X    60                                                      
REMARK 465     VAL X    61                                                      
REMARK 465     PHE X    62                                                      
REMARK 465     SER X    63                                                      
REMARK 465     PHE X    64                                                      
REMARK 465     TYR X    65                                                      
REMARK 465     CYS X    66                                                      
REMARK 465     SER X    67                                                      
REMARK 465     TYR X    68                                                      
REMARK 465     CYS X    69                                                      
REMARK 465     SER X    70                                                      
REMARK 465     ALA X    71                                                      
REMARK 465     GLY X    72                                                      
REMARK 465     ILE X    73                                                      
REMARK 465     THR X    74                                                      
REMARK 465     GLY X    75                                                      
REMARK 465     PRO X    76                                                      
REMARK 465     ALA X    77                                                      
REMARK 465     LEU X    78                                                      
REMARK 465     ILE X    79                                                      
REMARK 465     ASN X    80                                                      
REMARK 465     GLY X    81                                                      
REMARK 465     GLY X    82                                                      
REMARK 465     LYS X    83                                                      
REMARK 465     LEU X    84                                                      
REMARK 465     PRO X    85                                                      
REMARK 465     LYS X    86                                                      
REMARK 465     THR X    87                                                      
REMARK 465     LEU X    88                                                      
REMARK 465     TRP X    89                                                      
REMARK 465     LYS X    90                                                      
REMARK 465     ARG X    91                                                      
REMARK 465     LYS X    92                                                      
REMARK 465     CYS X    93                                                      
REMARK 465     ARG X    94                                                      
REMARK 465     LEU X    95                                                      
REMARK 465     PRO X    96                                                      
REMARK 465     GLU X    97                                                      
REMARK 465     CYS X    98                                                      
REMARK 465     TYR X    99                                                      
REMARK 465     THR X   100                                                      
REMARK 465     GLU X   101                                                      
REMARK 465     CYS X   102                                                      
REMARK 465     ASP X   103                                                      
REMARK 465     ALA X   104                                                      
REMARK 465     ASN X   105                                                      
REMARK 465     SER X   106                                                      
REMARK 465     ARG X   107                                                      
REMARK 465     SER X   108                                                      
REMARK 465     LYS X   109                                                      
REMARK 465     TYR X   110                                                      
REMARK 465     CYS X   111                                                      
REMARK 465     SER X   112                                                      
REMARK 465     LYS X   113                                                      
REMARK 465     LYS X   114                                                      
REMARK 465     HIS X   115                                                      
REMARK 465     ALA X   116                                                      
REMARK 465     VAL X   117                                                      
REMARK 465     GLN X   118                                                      
REMARK 465     TYR X   119                                                      
REMARK 465     VAL X   120                                                      
REMARK 465     GLN X   121                                                      
REMARK 465     SER X   122                                                      
REMARK 465     ILE X   123                                                      
REMARK 465     VAL X   124                                                      
REMARK 465     ASP X   125                                                      
REMARK 465     LYS X   126                                                      
REMARK 465     LEU X   127                                                      
REMARK 465     ASN X   128                                                      
REMARK 465     LEU X   129                                                      
REMARK 465     PRO X   130                                                      
REMARK 465     GLY X   131                                                      
REMARK 465     VAL X   132                                                      
REMARK 465     ASP X   133                                                      
REMARK 465     LYS X   134                                                      
REMARK 465     ILE X   135                                                      
REMARK 465     ALA X   136                                                      
REMARK 465     LEU X   137                                                      
REMARK 465     LEU X   138                                                      
REMARK 465     ARG X   139                                                      
REMARK 465     GLN X   140                                                      
REMARK 465     LEU X   141                                                      
REMARK 465     LEU X   142                                                      
REMARK 465     ASN X   143                                                      
REMARK 465     GLU X   144                                                      
REMARK 465     THR X   145                                                      
REMARK 465     THR X   146                                                      
REMARK 465     SER X   147                                                      
REMARK 465     LEU X   148                                                      
REMARK 465     GLU X   149                                                      
REMARK 465     GLU X   150                                                      
REMARK 465     PHE X   151                                                      
REMARK 465     LYS X   152                                                      
REMARK 465     THR X   153                                                      
REMARK 465     LEU X   154                                                      
REMARK 465     GLY X   155                                                      
REMARK 465     ARG X   156                                                      
REMARK 465     ASP X   157                                                      
REMARK 465     LYS X   158                                                      
REMARK 465     LEU X   159                                                      
REMARK 465     PRO X   160                                                      
REMARK 465     GLU X   161                                                      
REMARK 465     VAL X   162                                                      
REMARK 465     THR X   163                                                      
REMARK 465     SER X   164                                                      
REMARK 465     PRO X   165                                                      
REMARK 465     LEU X   166                                                      
REMARK 465     SER X   167                                                      
REMARK 465     LYS X   168                                                      
REMARK 465     ASP X   169                                                      
REMARK 465     GLN X   170                                                      
REMARK 465     TYR X   171                                                      
REMARK 465     SER X   172                                                      
REMARK 465     LYS X   173                                                      
REMARK 465     LEU X   174                                                      
REMARK 465     LEU X   175                                                      
REMARK 465     GLU X   176                                                      
REMARK 465     ASN X   177                                                      
REMARK 465     ASP X   178                                                      
REMARK 465     GLN X   179                                                      
REMARK 465     HIS X   180                                                      
REMARK 465     LEU X   181                                                      
REMARK 465     ASN X   182                                                      
REMARK 465     LYS X   183                                                      
REMARK 465     LEU X   184                                                      
REMARK 465     ILE X   185                                                      
REMARK 465     ASN X   186                                                      
REMARK 465     GLU X   187                                                      
REMARK 465     HIS X   188                                                      
REMARK 465     ASP X   189                                                      
REMARK 465     GLU X   190                                                      
REMARK 465     LEU X   191                                                      
REMARK 465     VAL X   192                                                      
REMARK 465     SER X   193                                                      
REMARK 465     VAL X   194                                                      
REMARK 465     ARG X   230                                                      
REMARK 465     LYS X   231                                                      
REMARK 465     LYS X   232                                                      
REMARK 465     SER X   233                                                      
REMARK 465     LYS X   234                                                      
REMARK 465     SER X   235                                                      
REMARK 465     ALA X   236                                                      
REMARK 465     SER X   237                                                      
REMARK 465     LYS X   238                                                      
REMARK 465     VAL X   239                                                      
REMARK 465     THR X   240                                                      
REMARK 465     ILE X   241                                                      
REMARK 465     CYS X   242                                                      
REMARK 465     GLY X   243                                                      
REMARK 465     TYR X   244                                                      
REMARK 465     HIS X   245                                                      
REMARK 465     ASN X   246                                                      
REMARK 465     GLU X   247                                                      
REMARK 465     PHE X   248                                                      
REMARK 465     THR X   249                                                      
REMARK 465     ILE X   250                                                      
REMARK 465     PRO X   251                                                      
REMARK 465     ARG X   252                                                      
REMARK 465     SER X   253                                                      
REMARK 465     VAL X   254                                                      
REMARK 465     GLU X   255                                                      
REMARK 465     GLU X   256                                                      
REMARK 465     PHE X   257                                                      
REMARK 465     LEU X   258                                                      
REMARK 465     ASP X   259                                                      
REMARK 465     LYS X   260                                                      
REMARK 465     LEU X   261                                                      
REMARK 465     LEU X   262                                                      
REMARK 465     GLN X   263                                                      
REMARK 465     LEU X   264                                                      
REMARK 465     LYS X   265                                                      
REMARK 465     GLU X   266                                                      
REMARK 465     ASP X   267                                                      
REMARK 465     GLU X   268                                                      
REMARK 465     ASN X   269                                                      
REMARK 465     SER X   270                                                      
REMARK 465     ASN X   271                                                      
REMARK 465     ILE X   272                                                      
REMARK 465     THR X   273                                                      
REMARK 465     SER X   274                                                      
REMARK 465     VAL X   275                                                      
REMARK 465     ASP X   276                                                      
REMARK 465     GLY X   277                                                      
REMARK 465     VAL X   278                                                      
REMARK 465     CYS X   279                                                      
REMARK 465     VAL X   280                                                      
REMARK 465     LYS X   281                                                      
REMARK 465     THR X   282                                                      
REMARK 465     LYS X   283                                                      
REMARK 465     CYS X   284                                                      
REMARK 465     ALA X   285                                                      
REMARK 465     LYS X   286                                                      
REMARK 465     HIS X   287                                                      
REMARK 465     GLN X   288                                                      
REMARK 465     ASP X   289                                                      
REMARK 465     PHE X   328                                                      
REMARK 465     GLU X   329                                                      
REMARK 465     GLN X   330                                                      
REMARK 465     GLU X   331                                                      
REMARK 465     MET X   332                                                      
REMARK 465     SER X   333                                                      
REMARK 465     ASN X   334                                                      
REMARK 465     ARG X   335                                                      
REMARK 465     VAL X   336                                                      
REMARK 465     LEU X   337                                                      
REMARK 465     PRO X   338                                                      
REMARK 465     GLY X   339                                                      
REMARK 465     VAL X   340                                                      
REMARK 465     LYS X   341                                                      
REMARK 465     THR X   342                                                      
REMARK 465     MET L     1                                                      
REMARK 465     ASP L   216                                                      
REMARK 465     ASP L   217                                                      
REMARK 465     SER L   218                                                      
REMARK 465     ARG L   219                                                      
REMARK 465     THR L   220                                                      
REMARK 465     ASN L   221                                                      
REMARK 465     LYS L   222                                                      
REMARK 465     ARG L   223                                                      
REMARK 465     ASN L   224                                                      
REMARK 465     LYS L   225                                                      
REMARK 465     TRP L   327                                                      
REMARK 465     ASN L   328                                                      
REMARK 465     LYS L   329                                                      
REMARK 465     ARG L   330                                                      
REMARK 465     ASN L   331                                                      
REMARK 465     VAL L   332                                                      
REMARK 465     THR L   333                                                      
REMARK 465     LYS L   334                                                      
REMARK 465     GLY L   335                                                      
REMARK 465     ILE L   336                                                      
REMARK 465     ASP L   404                                                      
REMARK 465     THR L   405                                                      
REMARK 465     MET O     1                                                      
REMARK 465     SER O     2                                                      
REMARK 465     GLU O     3                                                      
REMARK 465     PRO O     4                                                      
REMARK 465     VAL O     5                                                      
REMARK 465     MET O     6                                                      
REMARK 465     GLU O     7                                                      
REMARK 465     ASN O     8                                                      
REMARK 465     MET O     9                                                      
REMARK 465     ALA O    10                                                      
REMARK 465     PRO O    11                                                      
REMARK 465     GLU O    12                                                      
REMARK 465     ASP O    13                                                      
REMARK 465     VAL O    14                                                      
REMARK 465     VAL O    15                                                      
REMARK 465     LYS O    16                                                      
REMARK 465     LEU O    17                                                      
REMARK 465     GLU O    18                                                      
REMARK 465     LYS O    19                                                      
REMARK 465     GLU O    20                                                      
REMARK 465     GLU O    21                                                      
REMARK 465     HIS O    22                                                      
REMARK 465     ILE O    23                                                      
REMARK 465     VAL O    24                                                      
REMARK 465     PRO O    25                                                      
REMARK 465     ASP O    26                                                      
REMARK 465     ILE O    27                                                      
REMARK 465     GLY O    28                                                      
REMARK 465     VAL O    29                                                      
REMARK 465     SER O    30                                                      
REMARK 465     SER O    31                                                      
REMARK 465     ILE O    32                                                      
REMARK 465     SER O    33                                                      
REMARK 465     THR O    34                                                      
REMARK 465     THR O    35                                                      
REMARK 465     GLU O    36                                                      
REMARK 465     PRO O    37                                                      
REMARK 465     LEU O    38                                                      
REMARK 465     SER O    39                                                      
REMARK 465     PRO O    40                                                      
REMARK 465     SER O    41                                                      
REMARK 465     GLY O    42                                                      
REMARK 465     ILE O    43                                                      
REMARK 465     PRO O    44                                                      
REMARK 465     ARG O    45                                                      
REMARK 465     GLU O    46                                                      
REMARK 465     SER O    47                                                      
REMARK 465     SER O    48                                                      
REMARK 465     GLY O    49                                                      
REMARK 465     THR O    50                                                      
REMARK 465     VAL O    51                                                      
REMARK 465     THR O    52                                                      
REMARK 465     SER O    53                                                      
REMARK 465     ALA O    54                                                      
REMARK 465     THR O    55                                                      
REMARK 465     ALA O    56                                                      
REMARK 465     ALA O    57                                                      
REMARK 465     THR O    58                                                      
REMARK 465     THR O    59                                                      
REMARK 465     GLU O    60                                                      
REMARK 465     ARG O    61                                                      
REMARK 465     GLU O    62                                                      
REMARK 465     VAL O    63                                                      
REMARK 465     SER O    64                                                      
REMARK 465     PRO O    65                                                      
REMARK 465     LYS O    66                                                      
REMARK 465     LYS O    67                                                      
REMARK 465     GLU O    68                                                      
REMARK 465     LEU O    69                                                      
REMARK 465     GLN O    70                                                      
REMARK 465     ILE O    71                                                      
REMARK 465     ASP O    72                                                      
REMARK 465     HIS O    73                                                      
REMARK 465     ASP O    74                                                      
REMARK 465     ARG O    75                                                      
REMARK 465     VAL O    76                                                      
REMARK 465     ASP O    77                                                      
REMARK 465     PRO O    78                                                      
REMARK 465     VAL O    79                                                      
REMARK 465     ALA O    80                                                      
REMARK 465     MET O    81                                                      
REMARK 465     ILE O    82                                                      
REMARK 465     GLY O    83                                                      
REMARK 465     GLY O    84                                                      
REMARK 465     GLU O   127                                                      
REMARK 465     MET O   128                                                      
REMARK 465     ASN O   129                                                      
REMARK 465     GLN O   130                                                      
REMARK 465     LYS O   131                                                      
REMARK 465     PRO O   132                                                      
REMARK 465     SER O   133                                                      
REMARK 465     SER O   134                                                      
REMARK 465     MET P     1                                                      
REMARK 465     SER P     2                                                      
REMARK 465     GLU P     3                                                      
REMARK 465     PRO P     4                                                      
REMARK 465     VAL P     5                                                      
REMARK 465     MET P     6                                                      
REMARK 465     GLU P     7                                                      
REMARK 465     ASN P     8                                                      
REMARK 465     MET P     9                                                      
REMARK 465     ALA P    10                                                      
REMARK 465     PRO P    11                                                      
REMARK 465     GLU P    12                                                      
REMARK 465     ASP P    13                                                      
REMARK 465     VAL P    14                                                      
REMARK 465     VAL P    15                                                      
REMARK 465     LYS P    16                                                      
REMARK 465     LEU P    17                                                      
REMARK 465     GLU P    18                                                      
REMARK 465     LYS P    19                                                      
REMARK 465     GLU P    20                                                      
REMARK 465     GLU P    21                                                      
REMARK 465     HIS P    22                                                      
REMARK 465     ILE P    23                                                      
REMARK 465     VAL P    24                                                      
REMARK 465     PRO P    25                                                      
REMARK 465     ASP P    26                                                      
REMARK 465     ILE P    27                                                      
REMARK 465     GLY P    28                                                      
REMARK 465     VAL P    29                                                      
REMARK 465     SER P    30                                                      
REMARK 465     SER P    31                                                      
REMARK 465     ILE P    32                                                      
REMARK 465     SER P    33                                                      
REMARK 465     THR P    34                                                      
REMARK 465     THR P    35                                                      
REMARK 465     GLU P    36                                                      
REMARK 465     PRO P    37                                                      
REMARK 465     LEU P    38                                                      
REMARK 465     SER P    39                                                      
REMARK 465     PRO P    40                                                      
REMARK 465     SER P    41                                                      
REMARK 465     GLY P    42                                                      
REMARK 465     ILE P    43                                                      
REMARK 465     PRO P    44                                                      
REMARK 465     ARG P    45                                                      
REMARK 465     GLU P    46                                                      
REMARK 465     SER P    47                                                      
REMARK 465     SER P    48                                                      
REMARK 465     GLY P    49                                                      
REMARK 465     THR P    50                                                      
REMARK 465     VAL P    51                                                      
REMARK 465     THR P    52                                                      
REMARK 465     SER P    53                                                      
REMARK 465     ALA P    54                                                      
REMARK 465     THR P    55                                                      
REMARK 465     ALA P    56                                                      
REMARK 465     ALA P    57                                                      
REMARK 465     THR P    58                                                      
REMARK 465     THR P    59                                                      
REMARK 465     GLU P    60                                                      
REMARK 465     ARG P    61                                                      
REMARK 465     GLU P    62                                                      
REMARK 465     VAL P    63                                                      
REMARK 465     SER P    64                                                      
REMARK 465     PRO P    65                                                      
REMARK 465     LYS P    66                                                      
REMARK 465     LYS P    67                                                      
REMARK 465     GLU P    68                                                      
REMARK 465     LEU P    69                                                      
REMARK 465     GLN P    70                                                      
REMARK 465     ILE P    71                                                      
REMARK 465     ASP P    72                                                      
REMARK 465     HIS P    73                                                      
REMARK 465     ASP P    74                                                      
REMARK 465     ARG P    75                                                      
REMARK 465     VAL P    76                                                      
REMARK 465     ASP P    77                                                      
REMARK 465     ALA P   107                                                      
REMARK 465     ARG P   108                                                      
REMARK 465     GLU P   109                                                      
REMARK 465     LYS P   110                                                      
REMARK 465     PRO P   111                                                      
REMARK 465     GLU P   112                                                      
REMARK 465     GLU P   127                                                      
REMARK 465     MET P   128                                                      
REMARK 465     ASN P   129                                                      
REMARK 465     GLN P   130                                                      
REMARK 465     LYS P   131                                                      
REMARK 465     PRO P   132                                                      
REMARK 465     SER P   133                                                      
REMARK 465     SER P   134                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     CYS A 110    SG                                                  
REMARK 470     MET K  16    CG   SD   CE                                        
REMARK 470     GLU K 200    CG   CD   OE1  OE2                                  
REMARK 470     ASP N 197    CG   OD1  OD2                                       
REMARK 470     LYS L 226    CG   CD   CE   NZ                                   
REMARK 470     ARG P 116    CG   CD   NE   CZ   NH1  NH2                        
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   SG   CYS K   256     O    LEU K   302              2.09            
REMARK 500   OE2  GLU M   940     O    SER M   994              2.15            
REMARK 500   NH2  ARG E    42     OP2   DC I   144              2.17            
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND LENGTHS                                      
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,2(A3,1X,A1,I4,A1,1X,A4,3X),1X,F6.3)               
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   RES CSSEQI ATM2   DEVIATION                     
REMARK 500     DC I 111   O3'    DC I 111   C3'    -0.042                       
REMARK 500     DG J  82   O3'    DG J  82   C3'    -0.038                       
REMARK 500     DG J 101   O3'    DG J 101   C3'    -0.040                       
REMARK 500    PRO O 114   CD    PRO O 114   N       0.086                       
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: COVALENT BOND ANGLES                                       
REMARK 500                                                                      
REMARK 500 THE STEREOCHEMICAL PARAMETERS OF THE FOLLOWING RESIDUES              
REMARK 500 HAVE VALUES WHICH DEVIATE FROM EXPECTED VALUES BY MORE               
REMARK 500 THAN 6*RMSD (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 500 IDENTIFIER; SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                 
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT: (10X,I3,1X,A3,1X,A1,I4,A1,3(1X,A4,2X),12X,F5.1)              
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES PROTEIN: ENGH AND HUBER, 1999                        
REMARK 500 EXPECTED VALUES NUCLEIC ACID: CLOWNEY ET AL 1996                     
REMARK 500                                                                      
REMARK 500  M RES CSSEQI ATM1   ATM2   ATM3                                     
REMARK 500    TYR E  41   CB  -  CA  -  C   ANGL. DEV. = -27.1 DEGREES          
REMARK 500     DT I   2   O4' -  C1' -  N1  ANGL. DEV. =   1.8 DEGREES          
REMARK 500     DG I  33   O4' -  C1' -  N9  ANGL. DEV. =   2.5 DEGREES          
REMARK 500     DT I  46   O4' -  C1' -  N1  ANGL. DEV. =   2.4 DEGREES          
REMARK 500     DA I  97   O4' -  C1' -  N9  ANGL. DEV. =   2.1 DEGREES          
REMARK 500     DT I 112   O4' -  C1' -  N1  ANGL. DEV. =   2.0 DEGREES          
REMARK 500     DT I 127   O4' -  C1' -  N1  ANGL. DEV. =   1.9 DEGREES          
REMARK 500     DA I 135   O4' -  C1' -  N9  ANGL. DEV. =   2.4 DEGREES          
REMARK 500     DC J  20   O4' -  C1' -  N1  ANGL. DEV. =   1.9 DEGREES          
REMARK 500     DC J  34   O4' -  C1' -  N1  ANGL. DEV. =   1.9 DEGREES          
REMARK 500     DG J  86   O4' -  C1' -  N9  ANGL. DEV. =   2.3 DEGREES          
REMARK 500     DT J 107   O4' -  C1' -  N1  ANGL. DEV. =   1.9 DEGREES          
REMARK 500     DT J 109   O4' -  C1' -  N1  ANGL. DEV. =   2.0 DEGREES          
REMARK 500    LEU K 302   CB  -  CA  -  C   ANGL. DEV. = -16.9 DEGREES          
REMARK 500    LEU K 302   N   -  CA  -  C   ANGL. DEV. =  18.6 DEGREES          
REMARK 500    LEU N  20   CB  -  CA  -  C   ANGL. DEV. = -20.7 DEGREES          
REMARK 500    LEU N  20   N   -  CA  -  C   ANGL. DEV. =  18.3 DEGREES          
REMARK 500    THR N  21   CB  -  CA  -  C   ANGL. DEV. = -20.6 DEGREES          
REMARK 500    THR N  21   N   -  CA  -  C   ANGL. DEV. =  16.7 DEGREES          
REMARK 500    LEU N  88   CB  -  CA  -  C   ANGL. DEV. =  16.0 DEGREES          
REMARK 500    GLU N 212   CB  -  CA  -  C   ANGL. DEV. =  18.6 DEGREES          
REMARK 500    LYS N 213   N   -  CA  -  CB  ANGL. DEV. =  11.7 DEGREES          
REMARK 500    ASP N 413   N   -  CA  -  C   ANGL. DEV. = -19.6 DEGREES          
REMARK 500    ILE N 414   N   -  CA  -  C   ANGL. DEV. = -18.1 DEGREES          
REMARK 500    ASP L  83   N   -  CA  -  C   ANGL. DEV. = -18.1 DEGREES          
REMARK 500    PHE L 309   N   -  CA  -  CB  ANGL. DEV. = -15.8 DEGREES          
REMARK 500    PHE L 309   N   -  CA  -  C   ANGL. DEV. =  18.1 DEGREES          
REMARK 500    LEU L 310   CA  -  CB  -  CG  ANGL. DEV. =  14.4 DEGREES          
REMARK 500    PHE L 322   CB  -  CA  -  C   ANGL. DEV. =  13.5 DEGREES          
REMARK 500    LYS L 376   CB  -  CA  -  C   ANGL. DEV. =  21.4 DEGREES          
REMARK 500    LYS L 376   N   -  CA  -  C   ANGL. DEV. = -30.9 DEGREES          
REMARK 500    PRO O 114   C   -  N   -  CD  ANGL. DEV. = -14.2 DEGREES          
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    THR C  16       77.47     58.54                                   
REMARK 500    LYS C  36       33.32    -92.28                                   
REMARK 500    LEU C  97       57.45    -94.89                                   
REMARK 500    HIS D  46       74.07   -155.06                                   
REMARK 500    THR G  16       77.57     54.71                                   
REMARK 500    LYS G  36       33.33    -92.25                                   
REMARK 500    LYS G  74        7.82     88.77                                   
REMARK 500    LEU G  97       57.40   -105.14                                   
REMARK 500    HIS H  79      -31.38   -130.37                                   
REMARK 500    ASP K  20      -61.12   -103.70                                   
REMARK 500    ASP K  90       32.70    -95.47                                   
REMARK 500    ILE K 103      -63.24   -100.53                                   
REMARK 500    ASP K 131       37.41    -97.85                                   
REMARK 500    SER K 165       34.54    -97.06                                   
REMARK 500    TRP K 197       -9.86     82.25                                   
REMARK 500    ALA K 199       18.12     54.12                                   
REMARK 500    ASP K 201       26.54     82.57                                   
REMARK 500    PRO M 767       22.89    -79.91                                   
REMARK 500    ILE M 917      -67.64    -95.44                                   
REMARK 500    ALA M 925       27.86   -143.66                                   
REMARK 500    ASN M 967       18.69     59.05                                   
REMARK 500    LYS M 975       62.42     60.34                                   
REMARK 500    MET N  56       57.33    -94.08                                   
REMARK 500    GLN N  77      -61.02    -93.80                                   
REMARK 500    VAL N 124      -62.68   -103.68                                   
REMARK 500    GLU N 212     -173.32   -177.77                                   
REMARK 500    SER N 298       -1.47     71.03                                   
REMARK 500    LEU N 324      -63.28    -93.32                                   
REMARK 500    SER N 415       21.39     80.85                                   
REMARK 500    SER X 197        0.11    -66.69                                   
REMARK 500    LEU X 293       70.46     59.14                                   
REMARK 500    SER X 294       30.32    -92.76                                   
REMARK 500    LEU L   9     -169.66   -117.84                                   
REMARK 500    SER L  31      -61.61   -101.59                                   
REMARK 500    THR L 366      -61.09    -96.07                                   
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS                                         
REMARK 500                                                                      
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH          
REMARK 500 CIS AND TRANS CONFORMATION.  CIS BONDS, IF ANY, ARE LISTED           
REMARK 500 ON CISPEP RECORDS.  TRANS IS DEFINED AS 180 +/- 30 AND               
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.                                  
REMARK 500                                 MODEL     OMEGA                      
REMARK 500 THR A   45     VAL A   46                  146.70                    
REMARK 500 PHE L  309     LEU L  310                 -147.32                    
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: MAIN CHAIN PLANARITY                                       
REMARK 500                                                                      
REMARK 500 THE FOLLOWING RESIDUES HAVE A PSEUDO PLANARITY                       
REMARK 500 TORSION ANGLE, C(I) - CA(I) - N(I+1) - O(I), GREATER                 
REMARK 500 10.0 DEGREES. (M=MODEL NUMBER; RES=RESIDUE NAME;                     
REMARK 500 C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;                            
REMARK 500 I=INSERTION CODE).                                                   
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        ANGLE                                           
REMARK 500    VAL K 113         11.01                                           
REMARK 500    PRO L 308         10.04                                           
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 800                                                                      
REMARK 800 SITE                                                                 
REMARK 800 SITE_IDENTIFIER: AC1                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue SAM M 1101                
REMARK 800                                                                      
REMARK 800 SITE_IDENTIFIER: AC2                                                 
REMARK 800 EVIDENCE_CODE: SOFTWARE                                              
REMARK 800 SITE_DESCRIPTION: binding site for residue ZN M 1102                 
REMARK 900                                                                      
REMARK 900 RELATED ENTRIES                                                      
REMARK 900 RELATED ID: EMD-20765   RELATED DB: EMDB                             
REMARK 900 RELATED ID: EMD-20767   RELATED DB: EMDB                             
DBREF  6UGM A    1   135  UNP    Q92133   Q92133_XENLA     2    136             
DBREF  6UGM B    1   102  UNP    P62799   H4_XENLA         2    103             
DBREF  6UGM C   12   118  UNP    Q6AZJ8   Q6AZJ8_XENLA    13    119             
DBREF1 6UGM D   -2   122  UNP                  A0A1L8FQ56_XENLA                 
DBREF2 6UGM D     A0A1L8FQ56                          2         126             
DBREF  6UGM E    1   135  UNP    Q92133   Q92133_XENLA     2    136             
DBREF  6UGM F    1   102  UNP    P62799   H4_XENLA         2    103             
DBREF  6UGM G   12   118  UNP    Q6AZJ8   Q6AZJ8_XENLA    13    119             
DBREF  6UGM H   -2   122  UNP    P02281   H2B11_XENLA      2    126             
DBREF  6UGM I    1   147  PDB    6UGM     6UGM             1    147             
DBREF  6UGM J    1   146  PDB    6UGM     6UGM             1    146             
DBREF  6UGM K    1   327  UNP    Q6CLY5   Q6CLY5_KLULA     1    327             
DBREF  6UGM M  726  1000  UNP    Q6CIT4   SET1_KLULA     726   1000             
DBREF  6UGM N    1   439  UNP    Q6CXF3   Q6CXF3_KLULA     1    439             
DBREF  6UGM R    3     5  PDB    6UGM     6UGM             3      5             
DBREF  6UGM X    1   342  UNP    Q6CRQ4   Q6CRQ4_KLULA     1    342             
DBREF  6UGM L    1   405  UNP    Q6CTQ1   Q6CTQ1_KLULA     1    405             
DBREF  6UGM O    1   134  UNP    Q6CPN6   Q6CPN6_KLULA     1    134             
DBREF  6UGM P    1   134  UNP    Q6CPN6   Q6CPN6_KLULA     1    134             
SEQADV 6UGM PRO D    7  UNP  A0A1L8FQ5 ALA    11 CONFLICT                       
SEQADV 6UGM GLU M  761  UNP  Q6CIT4    ASP   761 CONFLICT                       
SEQRES   1 A  135  ALA ARG THR LYS GLN THR ALA ARG LYS SER THR GLY GLY          
SEQRES   2 A  135  LYS ALA PRO ARG LYS GLN LEU ALA THR LYS ALA ALA ARG          
SEQRES   3 A  135  LYS SER ALA PRO ALA THR GLY GLY VAL LYS LYS PRO HIS          
SEQRES   4 A  135  ARG TYR ARG PRO GLY THR VAL ALA LEU ARG GLU ILE ARG          
SEQRES   5 A  135  ARG TYR GLN LYS SER THR GLU LEU LEU ILE ARG LYS LEU          
SEQRES   6 A  135  PRO PHE GLN ARG LEU VAL ARG GLU ILE ALA GLN ASP PHE          
SEQRES   7 A  135  LYS THR ASP LEU ARG PHE GLN SER SER ALA VAL MET ALA          
SEQRES   8 A  135  LEU GLN GLU ALA SER GLU ALA TYR LEU VAL GLY LEU PHE          
SEQRES   9 A  135  GLU ASP THR ASN LEU CYS GLY ILE HIS ALA LYS ARG VAL          
SEQRES  10 A  135  THR ILE MET PRO LYS ASP ILE GLN LEU ALA ARG ARG ILE          
SEQRES  11 A  135  ARG GLY GLU ARG ALA                                          
SEQRES   1 B  102  SER GLY ARG GLY LYS GLY GLY LYS GLY LEU GLY LYS GLY          
SEQRES   2 B  102  GLY ALA LYS ARG HIS ARG LYS VAL LEU ARG ASP ASN ILE          
SEQRES   3 B  102  GLN GLY ILE THR LYS PRO ALA ILE ARG ARG LEU ALA ARG          
SEQRES   4 B  102  ARG GLY GLY VAL LYS ARG ILE SER GLY LEU ILE TYR GLU          
SEQRES   5 B  102  GLU THR ARG GLY VAL LEU LYS VAL PHE LEU GLU ASN VAL          
SEQRES   6 B  102  ILE ARG ASP ALA VAL THR TYR THR GLU HIS ALA LYS ARG          
SEQRES   7 B  102  LYS THR VAL THR ALA MET ASP VAL VAL TYR ALA LEU LYS          
SEQRES   8 B  102  ARG GLN GLY ARG THR LEU TYR GLY PHE GLY GLY                  
SEQRES   1 C  107  ALA LYS ALA LYS THR ARG SER SER ARG ALA GLY LEU GLN          
SEQRES   2 C  107  PHE PRO VAL GLY ARG VAL HIS ARG LEU LEU ARG LYS GLY          
SEQRES   3 C  107  ASN TYR ALA GLU ARG VAL GLY ALA GLY ALA PRO VAL TYR          
SEQRES   4 C  107  LEU ALA ALA VAL LEU GLU TYR LEU THR ALA GLU ILE LEU          
SEQRES   5 C  107  GLU LEU ALA GLY ASN ALA ALA ARG ASP ASN LYS LYS THR          
SEQRES   6 C  107  ARG ILE ILE PRO ARG HIS LEU GLN LEU ALA VAL ARG ASN          
SEQRES   7 C  107  ASP GLU GLU LEU ASN LYS LEU LEU GLY ARG VAL THR ILE          
SEQRES   8 C  107  ALA GLN GLY GLY VAL LEU PRO ASN ILE GLN SER VAL LEU          
SEQRES   9 C  107  LEU PRO LYS                                                  
SEQRES   1 D  125  PRO GLU PRO ALA LYS SER ALA PRO ALA PRO LYS LYS GLY          
SEQRES   2 D  125  SER LYS LYS ALA VAL THR LYS THR GLN LYS LYS ASP GLY          
SEQRES   3 D  125  LYS LYS ARG ARG LYS THR ARG LYS GLU SER TYR ALA ILE          
SEQRES   4 D  125  TYR VAL TYR LYS VAL LEU LYS GLN VAL HIS PRO ASP THR          
SEQRES   5 D  125  GLY ILE SER SER LYS ALA MET SER ILE MET ASN SER PHE          
SEQRES   6 D  125  VAL ASN ASP VAL PHE GLU ARG ILE ALA GLY GLU ALA SER          
SEQRES   7 D  125  ARG LEU ALA HIS TYR ASN LYS ARG SER THR ILE THR SER          
SEQRES   8 D  125  ARG GLU ILE GLN THR ALA VAL ARG LEU LEU LEU PRO GLY          
SEQRES   9 D  125  GLU LEU ALA LYS HIS ALA VAL SER GLU GLY THR LYS ALA          
SEQRES  10 D  125  VAL THR LYS TYR THR SER ALA LYS                              
SEQRES   1 E  135  ALA ARG THR LYS GLN THR ALA ARG LYS SER THR GLY GLY          
SEQRES   2 E  135  LYS ALA PRO ARG LYS GLN LEU ALA THR LYS ALA ALA ARG          
SEQRES   3 E  135  LYS SER ALA PRO ALA THR GLY GLY VAL LYS LYS PRO HIS          
SEQRES   4 E  135  ARG TYR ARG PRO GLY THR VAL ALA LEU ARG GLU ILE ARG          
SEQRES   5 E  135  ARG TYR GLN LYS SER THR GLU LEU LEU ILE ARG LYS LEU          
SEQRES   6 E  135  PRO PHE GLN ARG LEU VAL ARG GLU ILE ALA GLN ASP PHE          
SEQRES   7 E  135  LYS THR ASP LEU ARG PHE GLN SER SER ALA VAL MET ALA          
SEQRES   8 E  135  LEU GLN GLU ALA SER GLU ALA TYR LEU VAL GLY LEU PHE          
SEQRES   9 E  135  GLU ASP THR ASN LEU CYS GLY ILE HIS ALA LYS ARG VAL          
SEQRES  10 E  135  THR ILE MET PRO LYS ASP ILE GLN LEU ALA ARG ARG ILE          
SEQRES  11 E  135  ARG GLY GLU ARG ALA                                          
SEQRES   1 F  102  SER GLY ARG GLY LYS GLY GLY LYS GLY LEU GLY LYS GLY          
SEQRES   2 F  102  GLY ALA LYS ARG HIS ARG LYS VAL LEU ARG ASP ASN ILE          
SEQRES   3 F  102  GLN GLY ILE THR LYS PRO ALA ILE ARG ARG LEU ALA ARG          
SEQRES   4 F  102  ARG GLY GLY VAL LYS ARG ILE SER GLY LEU ILE TYR GLU          
SEQRES   5 F  102  GLU THR ARG GLY VAL LEU LYS VAL PHE LEU GLU ASN VAL          
SEQRES   6 F  102  ILE ARG ASP ALA VAL THR TYR THR GLU HIS ALA LYS ARG          
SEQRES   7 F  102  LYS THR VAL THR ALA MET ASP VAL VAL TYR ALA LEU LYS          
SEQRES   8 F  102  ARG GLN GLY ARG THR LEU TYR GLY PHE GLY GLY                  
SEQRES   1 G  107  ALA LYS ALA LYS THR ARG SER SER ARG ALA GLY LEU GLN          
SEQRES   2 G  107  PHE PRO VAL GLY ARG VAL HIS ARG LEU LEU ARG LYS GLY          
SEQRES   3 G  107  ASN TYR ALA GLU ARG VAL GLY ALA GLY ALA PRO VAL TYR          
SEQRES   4 G  107  LEU ALA ALA VAL LEU GLU TYR LEU THR ALA GLU ILE LEU          
SEQRES   5 G  107  GLU LEU ALA GLY ASN ALA ALA ARG ASP ASN LYS LYS THR          
SEQRES   6 G  107  ARG ILE ILE PRO ARG HIS LEU GLN LEU ALA VAL ARG ASN          
SEQRES   7 G  107  ASP GLU GLU LEU ASN LYS LEU LEU GLY ARG VAL THR ILE          
SEQRES   8 G  107  ALA GLN GLY GLY VAL LEU PRO ASN ILE GLN SER VAL LEU          
SEQRES   9 G  107  LEU PRO LYS                                                  
SEQRES   1 H  125  PRO GLU PRO ALA LYS SER ALA PRO ALA PRO LYS LYS GLY          
SEQRES   2 H  125  SER LYS LYS ALA VAL THR LYS THR GLN LYS LYS ASP GLY          
SEQRES   3 H  125  LYS LYS ARG ARG LYS SER ARG LYS GLU SER TYR ALA ILE          
SEQRES   4 H  125  TYR VAL TYR LYS VAL LEU LYS GLN VAL HIS PRO ASP THR          
SEQRES   5 H  125  GLY ILE SER SER LYS ALA MET SER ILE MET ASN SER PHE          
SEQRES   6 H  125  VAL ASN ASP VAL PHE GLU ARG ILE ALA GLY GLU ALA SER          
SEQRES   7 H  125  ARG LEU ALA HIS TYR ASN LYS ARG SER THR ILE THR SER          
SEQRES   8 H  125  ARG GLU ILE GLN THR ALA VAL ARG LEU LEU LEU PRO GLY          
SEQRES   9 H  125  GLU LEU ALA LYS HIS ALA VAL SER GLU GLY THR LYS ALA          
SEQRES  10 H  125  VAL THR LYS TYR THR SER ALA LYS                              
SEQRES   1 I  147   DC  DT  DC  DG  DA  DG  DA  DA  DT  DC  DC  DC  DG          
SEQRES   2 I  147   DG  DT  DG  DC  DC  DG  DA  DG  DG  DC  DC  DG  DC          
SEQRES   3 I  147   DT  DC  DA  DA  DT  DT  DG  DG  DT  DC  DG  DT  DA          
SEQRES   4 I  147   DG  DA  DC  DA  DG  DC  DT  DC  DT  DA  DG  DC  DA          
SEQRES   5 I  147   DC  DC  DG  DC  DT  DT  DA  DA  DA  DC  DG  DC  DA          
SEQRES   6 I  147   DC  DG  DT  DA  DC  DG  DC  DG  DC  DT  DG  DT  DC          
SEQRES   7 I  147   DC  DC  DC  DC  DG  DC  DG  DT  DT  DT  DT  DA  DA          
SEQRES   8 I  147   DC  DC  DG  DC  DC  DA  DA  DG  DG  DG  DG  DA  DT          
SEQRES   9 I  147   DT  DA  DC  DT  DC  DC  DC  DT  DA  DG  DT  DC  DT          
SEQRES  10 I  147   DC  DC  DA  DG  DG  DC  DA  DC  DG  DT  DG  DT  DC          
SEQRES  11 I  147   DA  DG  DA  DT  DA  DT  DA  DT  DA  DC  DA  DT  DC          
SEQRES  12 I  147   DC  DG  DA  DT                                              
SEQRES   1 J  146   DA  DT  DC  DG  DG  DA  DT  DG  DT  DA  DT  DA  DT          
SEQRES   2 J  146   DA  DT  DC  DT  DG  DA  DC  DA  DC  DG  DT  DG  DC          
SEQRES   3 J  146   DC  DT  DG  DG  DA  DG  DA  DC  DT  DA  DG  DG  DG          
SEQRES   4 J  146   DA  DG  DT  DA  DA  DT  DC  DC  DC  DC  DT  DT  DG          
SEQRES   5 J  146   DG  DC  DG  DG  DT  DT  DA  DA  DA  DA  DC  DG  DC          
SEQRES   6 J  146   DG  DG  DG  DG  DG  DA  DC  DA  DG  DC  DG  DC  DG          
SEQRES   7 J  146   DT  DA  DC  DG  DT  DG  DC  DG  DT  DT  DT  DA  DA          
SEQRES   8 J  146   DG  DC  DG  DG  DT  DG  DC  DT  DA  DG  DA  DG  DC          
SEQRES   9 J  146   DT  DG  DT  DC  DT  DA  DC  DG  DA  DC  DC  DA  DA          
SEQRES  10 J  146   DT  DT  DG  DA  DG  DC  DG  DG  DC  DC  DT  DC  DG          
SEQRES  11 J  146   DG  DC  DA  DC  DC  DG  DG  DG  DA  DT  DT  DC  DT          
SEQRES  12 J  146   DC  DG  DA                                                  
SEQRES   1 K  327  MET CYS ASP LEU ASP SER VAL SER ASP LEU THR LEU THR          
SEQRES   2 K  327  LEU ARG MET LEU GLN PHE ASP LYS GLN VAL LEU PRO ALA          
SEQRES   3 K  327  SER GLY LYS ILE SER THR SER CYS GLN ILE SER PRO ASP          
SEQRES   4 K  327  GLY GLU LEU ILE ALA ILE CYS GLN ASN THR ASP MET LEU          
SEQRES   5 K  327  VAL TYR GLU ILE SER SER SER LYS MET MET LYS LEU THR          
SEQRES   6 K  327  THR THR HIS LYS GLU CYS ILE ASN CYS LEU CYS TRP SER          
SEQRES   7 K  327  PRO ASP SER LYS CYS ILE ALA SER GLY SER GLU ASP PHE          
SEQRES   8 K  327  THR VAL GLU ILE THR HIS ILE ILE TYR GLY ARG ILE ARG          
SEQRES   9 K  327  ARG LEU MET GLY HIS THR ALA PRO VAL ILE SER ILE CYS          
SEQRES  10 K  327  TYR ASN ASN LYS GLY ASN ILE LEU CYS SER SER SER MET          
SEQRES  11 K  327  ASP GLU SER ILE LYS GLU TRP HIS VAL LEU SER GLY THR          
SEQRES  12 K  327  ALA LEU LYS THR MET SER ALA HIS SER ASP ALA VAL VAL          
SEQRES  13 K  327  SER ILE ASP ILE PRO LYS PHE ASP SER SER ILE LEU SER          
SEQRES  14 K  327  SER GLY SER TYR ASP GLY LEU ILE ARG ILE PHE ASP THR          
SEQRES  15 K  327  GLU SER GLY HIS CYS LEU LYS THR LEU THR TYR ASP LYS          
SEQRES  16 K  327  ASP TRP ILE ALA GLU ASP GLY VAL VAL PRO ILE SER THR          
SEQRES  17 K  327  VAL LYS PHE SER ARG ASN GLY LYS PHE LEU LEU VAL LYS          
SEQRES  18 K  327  SER LEU ASP ASN VAL VAL LYS LEU TRP GLU TYR THR ARG          
SEQRES  19 K  327  GLY THR VAL VAL ARG THR PHE LEU TRP PRO HIS GLN GLU          
SEQRES  20 K  327  THR LYS ALA LYS LEU LYS TYR ASN CYS GLY LEU GLU LEU          
SEQRES  21 K  327  ILE TYR PRO GLN GLY LYS ASP PRO LEU VAL ILE SER GLY          
SEQRES  22 K  327  ASN ASP SER GLY SER MET CYS VAL TRP ASN VAL TYR SER          
SEQRES  23 K  327  LYS ASN LEU VAL GLN LYS ILE ASP GLU LYS HIS ARG ASN          
SEQRES  24 K  327  SER PRO LEU ILE SER ILE SER ALA SER TYR ASP LYS VAL          
SEQRES  25 K  327  ALA THR LEU SER LEU ASN GLY GLU CYS ASN LEU PHE ARG          
SEQRES  26 K  327  VAL HIS                                                      
SEQRES   1 M  275  TYR GLN GLN ILE GLU GLN ASN GLY ILE ILE ARG ASP ASN          
SEQRES   2 M  275  GLN ILE ALA LEU ASN GLU LYS GLU PHE ASP SER THR LEU          
SEQRES   3 M  275  ALA SER THR THR GLY SER PHE ILE ALA GLU GLY PHE LYS          
SEQRES   4 M  275  LYS ILE PRO ASP LYS LEU LYS SER SER TYR LEU LEU HIS          
SEQRES   5 M  275  HIS ARG ARG LEU ALA GLN PRO LEU ASN THR VAL HIS ASN          
SEQRES   6 M  275  HIS GLN GLU GLN ASN PHE MET ALA LEU ASN GLY THR GLU          
SEQRES   7 M  275  SER THR ASN GLN GLU ALA ASP LEU GLU GLN ASP ASN HIS          
SEQRES   8 M  275  ASN ALA SER SER ARG LEU ASN ARG VAL PHE GLN ARG ARG          
SEQRES   9 M  275  PHE GLN GLN ASP ILE GLU ALA GLN ARG ALA ALA ILE GLY          
SEQRES  10 M  275  PHE GLU SER ASP LEU LEU SER LEU ASN GLN LEU THR LYS          
SEQRES  11 M  275  ARG LYS LYS PRO VAL THR PHE ALA ARG SER ALA ILE HIS          
SEQRES  12 M  275  ASN TRP GLY LEU TYR ALA LEU GLU PRO ILE ALA ALA LYS          
SEQRES  13 M  275  GLU MET ILE ILE GLU TYR VAL GLY GLU SER ILE ARG GLN          
SEQRES  14 M  275  PRO VAL ALA GLU MET ARG GLU LYS ARG TYR ILE LYS SER          
SEQRES  15 M  275  GLY ILE GLY SER SER TYR LEU PHE ARG ILE ASP GLU ASN          
SEQRES  16 M  275  THR VAL ILE ASP ALA THR LYS ARG GLY GLY ILE ALA ARG          
SEQRES  17 M  275  PHE ILE ASN HIS CYS CYS GLU PRO SER CYS THR ALA LYS          
SEQRES  18 M  275  ILE ILE LYS VAL ASP GLY ARG LYS ARG ILE VAL ILE TYR          
SEQRES  19 M  275  ALA LEU ARG ASP ILE GLY THR ASN GLU GLU LEU THR TYR          
SEQRES  20 M  275  ASP TYR LYS PHE GLU ARG GLU THR ASP GLU GLY GLU ARG          
SEQRES  21 M  275  LEU PRO CYS LEU CYS GLY ALA PRO SER CYS LYS GLY PHE          
SEQRES  22 M  275  LEU ASN                                                      
SEQRES   1 N  439  MET ALA ASN LEU LEU LEU GLN ASP PRO PHE GLY VAL LEU          
SEQRES   2 N  439  LYS GLU TYR PRO GLU LYS LEU THR HIS THR LEU GLU VAL          
SEQRES   3 N  439  PRO VAL ALA ALA VAL CYS VAL LYS PHE SER PRO ARG GLY          
SEQRES   4 N  439  ASP TYR LEU ALA VAL GLY CYS SER ASN GLY ALA ILE ILE          
SEQRES   5 N  439  ILE TYR ASP MET ASP SER LEU LYS PRO ILE ALA MET LEU          
SEQRES   6 N  439  GLY THR HIS SER GLY ALA HIS THR ARG SER VAL GLN SER          
SEQRES   7 N  439  VAL CYS TRP SER ASN ASP GLY ARG TYR LEU TRP SER SER          
SEQRES   8 N  439  GLY ARG ASP TRP TYR ALA LYS LEU TRP ASP MET THR GLN          
SEQRES   9 N  439  PRO THR LYS CYS PHE GLN GLN TYR LYS PHE ASP GLY PRO          
SEQRES  10 N  439  LEU TRP SER CYS HIS VAL VAL ARG TRP ASN VAL CYS ILE          
SEQRES  11 N  439  VAL THR VAL VAL GLU GLU PRO THR ALA TYR VAL LEU THR          
SEQRES  12 N  439  LEU THR ASP ARG GLN ASN ALA PHE HIS CYS PHE PRO LEU          
SEQRES  13 N  439  LEU GLU GLN ASP GLN ASP ILE SER GLY HIS GLY TYR THR          
SEQRES  14 N  439  LEU VAL ALA CYS PRO HIS PRO THR ILE GLU SER ILE ILE          
SEQRES  15 N  439  ILE THR GLY THR SER LYS GLY TRP ILE ASN ALA PHE GLN          
SEQRES  16 N  439  LEU ASP LEU GLU SER GLY PHE GLU ASP LYS ILE ARG CYS          
SEQRES  17 N  439  CYS TYR GLU GLU LYS ILE ALA ASN ALA ASN ILE LYS GLN          
SEQRES  18 N  439  ILE ILE ILE SER PRO SER GLY THR ARG ILE ALA ILE ASN          
SEQRES  19 N  439  GLY SER ASP ARG THR ILE ARG GLN TYR GLN LEU ILE VAL          
SEQRES  20 N  439  GLU ASP ASN GLU SER GLU GLY GLY SER SER HIS SER VAL          
SEQRES  21 N  439  SER ILE GLU LEU GLU HIS LYS TYR GLN ASP ILE ILE ASN          
SEQRES  22 N  439  ARG LEU GLN TRP ASN THR ILE PHE PHE SER ASN HIS SER          
SEQRES  23 N  439  GLY GLU TYR LEU VAL ALA SER ALA HIS GLY SER SER ALA          
SEQRES  24 N  439  HIS ASP LEU TYR LEU TRP GLU THR SER SER GLY SER LEU          
SEQRES  25 N  439  VAL ARG VAL LEU GLU GLY ALA ASP GLU GLU LEU LEU ASP          
SEQRES  26 N  439  ILE ASP TRP ASN PHE TYR SER MET ARG ILE ALA SER ASN          
SEQRES  27 N  439  GLY PHE GLU SER GLY TRP VAL TYR MET TRP SER ILE VAL          
SEQRES  28 N  439  ILE PRO PRO LYS TRP SER ALA LEU ALA PRO ASP PHE GLU          
SEQRES  29 N  439  GLU VAL GLU GLU ASN ILE ASP TYR GLN GLU LYS GLU ASN          
SEQRES  30 N  439  GLU PHE ASP ILE MET ASP ASP ASP ASN ASN LEU GLN ALA          
SEQRES  31 N  439  MET THR GLU ALA GLU GLU ILE ALA ILE ASP LEU CYS THR          
SEQRES  32 N  439  PRO GLU LYS TYR ASP VAL ARG GLY ASN ASP ILE SER MET          
SEQRES  33 N  439  PRO SER PHE VAL ILE PRO ILE ASP TYR GLU GLY VAL ILE          
SEQRES  34 N  439  ILE GLN GLN HIS TRP ALA HIS GLN GLU GLN                      
SEQRES   1 R    3  THR MET GLN                                                  
SEQRES   1 X  342  MET SER LEU PRO SER TRP CYS PRO ARG TYR ASP SER ARG          
SEQRES   2 X  342  LYS HIS ASP PRO LYS THR GLY GLU GLU VAL TYR CYS ILE          
SEQRES   3 X  342  CYS LYS LYS PRO ASP THR GLY GLU LEU MET VAL GLY CYS          
SEQRES   4 X  342  ASP GLY CYS ASP ASP TRP PHE HIS PHE SER CYS LEU LYS          
SEQRES   5 X  342  ILE PRO GLU LYS TYR ARG ASP LEU VAL PHE SER PHE TYR          
SEQRES   6 X  342  CYS SER TYR CYS SER ALA GLY ILE THR GLY PRO ALA LEU          
SEQRES   7 X  342  ILE ASN GLY GLY LYS LEU PRO LYS THR LEU TRP LYS ARG          
SEQRES   8 X  342  LYS CYS ARG LEU PRO GLU CYS TYR THR GLU CYS ASP ALA          
SEQRES   9 X  342  ASN SER ARG SER LYS TYR CYS SER LYS LYS HIS ALA VAL          
SEQRES  10 X  342  GLN TYR VAL GLN SER ILE VAL ASP LYS LEU ASN LEU PRO          
SEQRES  11 X  342  GLY VAL ASP LYS ILE ALA LEU LEU ARG GLN LEU LEU ASN          
SEQRES  12 X  342  GLU THR THR SER LEU GLU GLU PHE LYS THR LEU GLY ARG          
SEQRES  13 X  342  ASP LYS LEU PRO GLU VAL THR SER PRO LEU SER LYS ASP          
SEQRES  14 X  342  GLN TYR SER LYS LEU LEU GLU ASN ASP GLN HIS LEU ASN          
SEQRES  15 X  342  LYS LEU ILE ASN GLU HIS ASP GLU LEU VAL SER VAL LYS          
SEQRES  16 X  342  LEU SER LYS LEU ASN GLU GLU ASP ALA VAL ILE GLU LYS          
SEQRES  17 X  342  TYR VAL ASN TRP ILE GLY GLU VAL ASN GLU ARG LEU SER          
SEQRES  18 X  342  PRO HIS PHE ASN GLN PRO THR GLY ARG LYS LYS SER LYS          
SEQRES  19 X  342  SER ALA SER LYS VAL THR ILE CYS GLY TYR HIS ASN GLU          
SEQRES  20 X  342  PHE THR ILE PRO ARG SER VAL GLU GLU PHE LEU ASP LYS          
SEQRES  21 X  342  LEU LEU GLN LEU LYS GLU ASP GLU ASN SER ASN ILE THR          
SEQRES  22 X  342  SER VAL ASP GLY VAL CYS VAL LYS THR LYS CYS ALA LYS          
SEQRES  23 X  342  HIS GLN ASP TRP ILE THR LEU SER GLN ASN ASP LEU SER          
SEQRES  24 X  342  GLU GLN LYS ASP SER LEU GLU ASN VAL LYS ARG ARG LEU          
SEQRES  25 X  342  ASP LEU LEU ILE SER VAL ARG THR ASN GLN LEU ARG ILE          
SEQRES  26 X  342  SER PHE PHE GLU GLN GLU MET SER ASN ARG VAL LEU PRO          
SEQRES  27 X  342  GLY VAL LYS THR                                              
SEQRES   1 L  405  MET SER VAL PRO VAL ILE PRO TYR LEU ASP TYR ASP ILE          
SEQRES   2 L  405  VAL ASP LEU GLY SER ASP ILE LYS LYS PRO ASP PHE PRO          
SEQRES   3 L  405  GLN LEU SER GLU SER HIS ARG ILE ASN GLU GLN GLN TYR          
SEQRES   4 L  405  TYR ILE THR GLU ASP THR PRO LEU ASN LYS ARG ASN PHE          
SEQRES   5 L  405  MET TYR GLN PRO CYS ALA ALA ASN LEU MET LEU ASP LYS          
SEQRES   6 L  405  LEU LYS TYR CYS GLY THR ASP TYR PHE ASP LYS SER SER          
SEQRES   7 L  405  ILE ASN LEU MET ASP ARG SER ASP LYS LEU ALA PHE SER          
SEQRES   8 L  405  LEU ASP ASP HIS SER VAL SER VAL SER GLU ASN CYS GLY          
SEQRES   9 L  405  TRP ARG SER VAL ARG SER ASP VAL CYS MET LYS GLU GLY          
SEQRES  10 L  405  LYS ILE TYR TRP GLU VAL GLU VAL LYS ASN VAL SER ASP          
SEQRES  11 L  405  THR SER HIS ILE ARG CYS GLY ILE SER ARG ARG GLU ALA          
SEQRES  12 L  405  SER THR GLU THR PRO VAL GLY CYS ASP PHE TYR GLY TYR          
SEQRES  13 L  405  SER ILE ARG ASP LYS GLY LEU GLN VAL ILE HIS GLU GLY          
SEQRES  14 L  405  ARG LEU HIS THR VAL LEU LYS PRO HIS GLU MET GLN ALA          
SEQRES  15 L  405  GLY ASP ARG ILE GLY PHE LEU LEU THR LEU PRO SER LEU          
SEQRES  16 L  405  GLN SER GLN SER GLU GLN ALA MET ASP TYR SER LEU LYS          
SEQRES  17 L  405  ARG ILE GLN GLU LEU ASN ASN ASP ASP SER ARG THR ASN          
SEQRES  18 L  405  LYS ARG ASN LYS LYS PHE ASN LYS GLU PHE TYR LYS PHE          
SEQRES  19 L  405  LEU LEU ARG SER CYS GLU PRO THR ASN VAL VAL ARG ASP          
SEQRES  20 L  405  GLN ILE ALA ILE ARG TYR LYS ASN GLN LEU PHE TYR GLU          
SEQRES  21 L  405  SER THR ASP TYR VAL LYS THR THR LYS PRO GLU TYR TYR          
SEQRES  22 L  405  ASP ASN ARG ASP ASP MET GLN LYS PHE TYR GLU LEU GLU          
SEQRES  23 L  405  ASN SER SER PHE GLU VAL PHE VAL ASN GLY VAL SER HIS          
SEQRES  24 L  405  GLY ILE ALA PHE GLU GLY LEU THR PRO PHE LEU PRO PRO          
SEQRES  25 L  405  PHE SER GLU LEU GLN TYR ASN GLU LYS PHE TYR LEU HIS          
SEQRES  26 L  405  HIS TRP ASN LYS ARG ASN VAL THR LYS GLY ILE GLU ILE          
SEQRES  27 L  405  ARG ASN LYS TYR VAL ASN ASN ASN ARG LEU GLY TYR TYR          
SEQRES  28 L  405  ALA THR LEU SER SER PHE GLN GLY GLY THR ALA SER ILE          
SEQRES  29 L  405  ILE THR GLU ALA MET GLU LEU LYS PHE LEU PRO LYS ASP          
SEQRES  30 L  405  VAL ASP ILE LYS THR LEU ASN ASP ILE TYR ASN GLU GLN          
SEQRES  31 L  405  ILE ALA SER ASP ILE VAL TRP ASP LEU ILE ASP GLU ILE          
SEQRES  32 L  405  ASP THR                                                      
SEQRES   1 O  134  MET SER GLU PRO VAL MET GLU ASN MET ALA PRO GLU ASP          
SEQRES   2 O  134  VAL VAL LYS LEU GLU LYS GLU GLU HIS ILE VAL PRO ASP          
SEQRES   3 O  134  ILE GLY VAL SER SER ILE SER THR THR GLU PRO LEU SER          
SEQRES   4 O  134  PRO SER GLY ILE PRO ARG GLU SER SER GLY THR VAL THR          
SEQRES   5 O  134  SER ALA THR ALA ALA THR THR GLU ARG GLU VAL SER PRO          
SEQRES   6 O  134  LYS LYS GLU LEU GLN ILE ASP HIS ASP ARG VAL ASP PRO          
SEQRES   7 O  134  VAL ALA MET ILE GLY GLY SER THR THR ARG ARG TYR LEU          
SEQRES   8 O  134  ASN GLU HIS VAL THR LYS HIS LEU LEU GLU GLY MET LYS          
SEQRES   9 O  134  LEU ILE ALA ARG GLU LYS PRO GLU ASP PRO LEU ARG VAL          
SEQRES  10 O  134  LEU GLY GLN PHE LEU ILE ASP ALA SER GLU MET ASN GLN          
SEQRES  11 O  134  LYS PRO SER SER                                              
SEQRES   1 P  134  MET SER GLU PRO VAL MET GLU ASN MET ALA PRO GLU ASP          
SEQRES   2 P  134  VAL VAL LYS LEU GLU LYS GLU GLU HIS ILE VAL PRO ASP          
SEQRES   3 P  134  ILE GLY VAL SER SER ILE SER THR THR GLU PRO LEU SER          
SEQRES   4 P  134  PRO SER GLY ILE PRO ARG GLU SER SER GLY THR VAL THR          
SEQRES   5 P  134  SER ALA THR ALA ALA THR THR GLU ARG GLU VAL SER PRO          
SEQRES   6 P  134  LYS LYS GLU LEU GLN ILE ASP HIS ASP ARG VAL ASP PRO          
SEQRES   7 P  134  VAL ALA MET ILE GLY GLY SER THR THR ARG ARG TYR LEU          
SEQRES   8 P  134  ASN GLU HIS VAL THR LYS HIS LEU LEU GLU GLY MET LYS          
SEQRES   9 P  134  LEU ILE ALA ARG GLU LYS PRO GLU ASP PRO LEU ARG VAL          
SEQRES  10 P  134  LEU GLY GLN PHE LEU ILE ASP ALA SER GLU MET ASN GLN          
SEQRES  11 P  134  LYS PRO SER SER                                              
HET    SAM  M1101      27                                                       
HET     ZN  M1102       1                                                       
HETNAM     SAM S-ADENOSYLMETHIONINE                                             
HETNAM      ZN ZINC ION                                                         
FORMUL  19  SAM    C15 H22 N6 O5 S                                              
FORMUL  20   ZN    ZN 2+                                                        
HELIX    1 AA1 VAL A   46  GLN A   55  1                                  10    
HELIX    2 AA2 LYS A   64  GLN A   76  1                                  13    
HELIX    3 AA3 SER A   86  HIS A  113  1                                  28    
HELIX    4 AA4 MET A  120  ARG A  131  1                                  12    
HELIX    5 AA5 ASN B   25  ILE B   29  5                                   5    
HELIX    6 AA6 THR B   30  GLY B   42  1                                  13    
HELIX    7 AA7 LEU B   49  THR B   54  1                                   6    
HELIX    8 AA8 THR B   54  HIS B   75  1                                  22    
HELIX    9 AA9 ALA B   83  GLY B   94  1                                  12    
HELIX   10 AB1 THR C   16  GLY C   22  1                                   7    
HELIX   11 AB2 PRO C   26  LEU C   33  1                                   8    
HELIX   12 AB3 GLY C   46  ASP C   72  1                                  27    
HELIX   13 AB4 ILE C   79  ARG C   88  1                                  10    
HELIX   14 AB5 TYR D   34  HIS D   46  1                                  13    
HELIX   15 AB6 SER D   53  ASN D   81  1                                  29    
HELIX   16 AB7 THR D   87  LEU D   99  1                                  13    
HELIX   17 AB8 GLY D  101  SER D  120  1                                  20    
HELIX   18 AB9 VAL E   46  LYS E   56  1                                  11    
HELIX   19 AC1 ARG E   63  ALA E   75  1                                  13    
HELIX   20 AC2 SER E   96  ALA E  114  1                                  19    
HELIX   21 AC3 MET E  120  GLY E  132  1                                  13    
HELIX   22 AC4 ASN F   25  ILE F   29  5                                   5    
HELIX   23 AC5 THR F   30  GLY F   42  1                                  13    
HELIX   24 AC6 GLU F   53  LYS F   77  1                                  25    
HELIX   25 AC7 THR F   82  GLN F   93  1                                  12    
HELIX   26 AC8 THR G   16  GLY G   22  1                                   7    
HELIX   27 AC9 PRO G   26  LEU G   33  1                                   8    
HELIX   28 AD1 GLY G   46  ASP G   72  1                                  27    
HELIX   29 AD2 ILE G   79  ARG G   88  1                                  10    
HELIX   30 AD3 ASP G   90  LEU G   97  1                                   8    
HELIX   31 AD4 TYR H   34  HIS H   46  1                                  13    
HELIX   32 AD5 SER H   53  ALA H   74  1                                  22    
HELIX   33 AD6 ARG H   76  ASN H   81  1                                   6    
HELIX   34 AD7 ARG H   89  LEU H   99  1                                  11    
HELIX   35 AD8 PRO H  100  GLU H  102  5                                   3    
HELIX   36 AD9 LEU H  103  ALA H  121  1                                  19    
HELIX   37 AE1 GLN M  727  ASN M  732  1                                   6    
HELIX   38 AE2 ASN M  738  GLU M  744  1                                   7    
HELIX   39 AE3 GLN M  894  GLY M  908  1                                  15    
HELIX   40 AE4 ILE M  931  ILE M  935  5                                   5    
HELIX   41 AE5 ASN N    3  ASP N    8  1                                   6    
HELIX   42 AE6 LYS N  355  LEU N  359  5                                   5    
HELIX   43 AE7 GLU N  376  ASP N  380  5                                   5    
HELIX   44 AE8 ILE N  429  HIS N  433  5                                   5    
HELIX   45 AE9 LEU X  199  ASN X  211  1                                  13    
HELIX   46 AF1 ILE X  213  GLU X  218  1                                   6    
HELIX   47 AF2 ARG X  219  PHE X  224  5                                   6    
HELIX   48 AF3 ASN X  296  GLU X  300  5                                   5    
HELIX   49 AF4 ASP X  303  SER X  317  1                                  15    
HELIX   50 AF5 VAL X  318  ARG X  324  1                                   7    
HELIX   51 AF6 SER L  194  ARG L  209  1                                  16    
HELIX   52 AF7 LYS L  229  SER L  238  1                                  10    
HELIX   53 AF8 THR L  382  ASP L  398  1                                  17    
HELIX   54 AF9 THR O   86  LEU O   91  1                                   6    
HELIX   55 AG1 ASN O   92  HIS O   94  5                                   3    
HELIX   56 AG2 LYS O   97  LYS O  104  1                                   8    
HELIX   57 AG3 PRO O  114  SER O  126  1                                  13    
HELIX   58 AG4 VAL P   79  GLY P   83  1                                   5    
HELIX   59 AG5 ARG P   89  GLU P   93  5                                   5    
HELIX   60 AG6 VAL P   95  LYS P  104  1                                  10    
HELIX   61 AG7 VAL P  117  LEU P  122  1                                   6    
SHEET    1 AA1 2 ARG A  83  PHE A  84  0                                        
SHEET    2 AA1 2 THR B  80  VAL B  81  1  O  VAL B  81   N  ARG A  83           
SHEET    1 AA2 2 THR C 101  ILE C 102  0                                        
SHEET    2 AA2 2 LEU F  97  TYR F  98  1  O  TYR F  98   N  THR C 101           
SHEET    1 AA3 2 ARG E  83  PHE E  84  0                                        
SHEET    2 AA3 2 THR F  80  VAL F  81  1  O  VAL F  81   N  ARG E  83           
SHEET    1 AA4 2 THR E 118  ILE E 119  0                                        
SHEET    2 AA4 2 ARG F  45  ILE F  46  1  O  ARG F  45   N  ILE E 119           
SHEET    1 AA5 2 GLN K  18  GLN K  22  0                                        
SHEET    2 AA5 2 ASN K 322  ARG K 325 -1  O  ARG K 325   N  GLN K  18           
SHEET    1 AA6 4 CYS K  34  ILE K  36  0                                        
SHEET    2 AA6 4 LEU K  42  GLN K  47 -1  O  ALA K  44   N  GLN K  35           
SHEET    3 AA6 4 ASP K  50  GLU K  55 -1  O  ASP K  50   N  GLN K  47           
SHEET    4 AA6 4 MET K  62  LEU K  64 -1  O  MET K  62   N  VAL K  53           
SHEET    1 AA7 4 CYS K  74  TRP K  77  0                                        
SHEET    2 AA7 4 CYS K  83  SER K  88 -1  O  ALA K  85   N  CYS K  76           
SHEET    3 AA7 4 THR K  92  HIS K  97 -1  O  THR K  96   N  ILE K  84           
SHEET    4 AA7 4 ARG K 102  ARG K 105 -1  O  ILE K 103   N  ILE K  95           
SHEET    1 AA8 3 ILE K 124  SER K 129  0                                        
SHEET    2 AA8 3 SER K 133  HIS K 138 -1  O  SER K 133   N  SER K 129           
SHEET    3 AA8 3 ALA K 144  MET K 148 -1  O  MET K 148   N  ILE K 134           
SHEET    1 AA9 4 VAL K 155  ASP K 159  0                                        
SHEET    2 AA9 4 ILE K 167  SER K 172 -1  O  GLY K 171   N  SER K 157           
SHEET    3 AA9 4 ARG K 178  ASP K 181 -1  O  PHE K 180   N  LEU K 168           
SHEET    4 AA9 4 CYS K 187  THR K 190 -1  O  LYS K 189   N  ILE K 179           
SHEET    1 AB1 4 ILE K 206  PHE K 211  0                                        
SHEET    2 AB1 4 PHE K 217  SER K 222 -1  O  LEU K 219   N  LYS K 210           
SHEET    3 AB1 4 VAL K 227  GLU K 231 -1  O  TRP K 230   N  LEU K 218           
SHEET    4 AB1 4 VAL K 237  PHE K 241 -1  O  PHE K 241   N  VAL K 227           
SHEET    1 AB2 3 LEU K 258  LEU K 260  0                                        
SHEET    2 AB2 3 VAL K 270  SER K 272 -1  O  ILE K 271   N  GLU K 259           
SHEET    3 AB2 3 VAL K 281  TRP K 282 -1  O  TRP K 282   N  VAL K 270           
SHEET    1 AB3 2 ILE K 305  SER K 306  0                                        
SHEET    2 AB3 2 ALA K 313  THR K 314 -1  O  ALA K 313   N  SER K 306           
SHEET    1 AB4 2 THR M 861  ARG M 864  0                                        
SHEET    2 AB4 2 TRP M 870  TYR M 873 -1  O  TYR M 873   N  THR M 861           
SHEET    1 AB5 3 ILE M 885  TYR M 887  0                                        
SHEET    2 AB5 3 ILE M 956  ILE M 958 -1  O  ILE M 956   N  TYR M 887           
SHEET    3 AB5 3 ALA M 945  ILE M 947 -1  N  LYS M 946   O  VAL M 957           
SHEET    1 AB6 2 ILE M 892  ARG M 893  0                                        
SHEET    2 AB6 2 THR M 921  VAL M 922 -1  O  VAL M 922   N  ILE M 892           
SHEET    1 AB7 4 LYS N  19  LEU N  24  0                                        
SHEET    2 AB7 4 VAL N 345  SER N 349 -1  O  VAL N 345   N  LEU N  24           
SHEET    3 AB7 4 ARG N 334  ASN N 338 -1  N  SER N 337   O  TYR N 346           
SHEET    4 AB7 4 ASP N 327  ASN N 329 -1  N  ASP N 327   O  ALA N 336           
SHEET    1 AB8 3 ALA N  30  PHE N  35  0                                        
SHEET    2 AB8 3 TYR N  41  CYS N  46 -1  O  GLY N  45   N  VAL N  31           
SHEET    3 AB8 3 TYR N  54  ASP N  55 -1  O  TYR N  54   N  LEU N  42           
SHEET    1 AB9 4 VAL N  76  TRP N  81  0                                        
SHEET    2 AB9 4 TYR N  87  GLY N  92 -1  O  SER N  91   N  SER N  78           
SHEET    3 AB9 4 ALA N  97  ASP N 101 -1  O  TRP N 100   N  LEU N  88           
SHEET    4 AB9 4 CYS N 108  GLN N 110 -1  O  PHE N 109   N  LEU N  99           
SHEET    1 AC1 2 LEU N 118  VAL N 123  0                                        
SHEET    2 AC1 2 CYS N 129  VAL N 133 -1  O  ILE N 130   N  HIS N 122           
SHEET    1 AC2 2 TYR N 140  VAL N 141  0                                        
SHEET    2 AC2 2 PHE N 154  PRO N 155 -1  N  PHE N 154   O  VAL N 141           
SHEET    1 AC3 3 THR N 169  PRO N 174  0                                        
SHEET    2 AC3 3 ILE N 181  THR N 186 -1  O  ILE N 183   N  CYS N 173           
SHEET    3 AC3 3 ILE N 191  GLN N 195 -1  O  PHE N 194   N  ILE N 182           
SHEET    1 AC4 4 GLN N 221  ILE N 224  0                                        
SHEET    2 AC4 4 ARG N 230  ASN N 234 -1  O  ASN N 234   N  GLN N 221           
SHEET    3 AC4 4 ILE N 240  VAL N 247 -1  O  TYR N 243   N  ILE N 231           
SHEET    4 AC4 4 VAL N 260  TYR N 268 -1  O  GLU N 265   N  GLN N 242           
SHEET    1 AC5 4 TRP N 277  PHE N 282  0                                        
SHEET    2 AC5 4 TYR N 289  ALA N 294 -1  O  SER N 293   N  ASN N 278           
SHEET    3 AC5 4 LEU N 302  GLU N 306 -1  O  TRP N 305   N  LEU N 290           
SHEET    4 AC5 4 LEU N 312  LEU N 316 -1  O  LEU N 316   N  LEU N 302           
SHEET    1 AC6 3 PHE L  52  GLN L  55  0                                        
SHEET    2 AC6 3 GLN L 256  THR L 262 -1  O  TYR L 259   N  GLN L  55           
SHEET    3 AC6 3 GLN L 248  TYR L 253 -1  N  TYR L 253   O  GLN L 256           
SHEET    1 AC7 2 CYS L  57  ALA L  58  0                                        
SHEET    2 AC7 2 CYS L  69  GLY L  70 -1  O  CYS L  69   N  ALA L  58           
SHEET    1 AC8 6 LEU L  88  ALA L  89  0                                        
SHEET    2 AC8 6 SER L  96  VAL L  99 -1  O  SER L  98   N  ALA L  89           
SHEET    3 AC8 6 ALA L 362  ILE L 365 -1  O  ALA L 362   N  VAL L  97           
SHEET    4 AC8 6 LYS L 118  VAL L 125 -1  N  GLU L 124   O  SER L 363           
SHEET    5 AC8 6 ASP L 184  THR L 191 -1  O  ILE L 186   N  VAL L 123           
SHEET    6 AC8 6 SER L 289  GLU L 291 -1  O  GLU L 291   N  LEU L 189           
SHEET    1 AC9 3 TRP L 105  MET L 114  0                                        
SHEET    2 AC9 3 TYR L 350  PHE L 357 -1  O  LEU L 354   N  VAL L 108           
SHEET    3 AC9 3 HIS L 133  ARG L 140 -1  N  SER L 139   O  TYR L 351           
SHEET    1 AD1 2 VAL L 165  HIS L 167  0                                        
SHEET    2 AD1 2 ARG L 170  HIS L 172 -1  O  HIS L 172   N  VAL L 165           
SHEET    1 AD2 2 GLU L 271  TYR L 272  0                                        
SHEET    2 AD2 2 LYS L 281  PHE L 282 -1  O  LYS L 281   N  TYR L 272           
LINK         SG  CYS M 988                ZN    ZN M1102     1555   1555  2.64  
SITE     1 AC1 18 ILE M 867  HIS M 868  TRP M 870  GLY M 910                    
SITE     2 AC1 18 SER M 911  SER M 912  TYR M 913  ARG M 933                    
SITE     3 AC1 18 PHE M 934  ASN M 936  HIS M 937  TYR M 974                    
SITE     4 AC1 18 PRO M 987  CYS M 988  LEU M 989  CYS M 990                    
SITE     5 AC1 18 LEU M 999  MET R   4                                          
SITE     1 AC2  4 CYS M 988  CYS M 990  ALA M 992  CYS M 995                    
CRYST1    1.000    1.000    1.000  90.00  90.00  90.00 P 1                      
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      1.000000  0.000000  0.000000        0.00000                         
SCALE2      0.000000  1.000000  0.000000        0.00000                         
SCALE3      0.000000  0.000000  1.000000        0.00000                         
(ATOM LINES ARE NOT SHOWN.)
END                                                                             
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