LinkDB: ApbA
Original site: ApbA
Chemical reaction (1) KEGG ENZYME (1) Gene (128053) KEGG GENES (128053) Protein sequence (46747) UniProt (46706) SWISS-PROT (41) 3D Structure (19) PDB (18) SCOP (1) Protein domain (2) InterPro (1) NCBI-CDD (1) Literature (2) PubMed (2) All databases (174824)
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#=GF ID ApbA #=GF AC PF02558.18 #=GF DE Ketopantoate reductase PanE/ApbA #=GF AU Bashton M;0000-0002-6847-1525 #=GF AU Bateman A;0000-0002-6982-4660 #=GF SE COGs #=GF GA 22.20 22.20; #=GF TC 22.20 22.20; #=GF NC 22.10 22.10; #=GF BM hmmbuild HMM.ann SEED.ann #=GF SM hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq #=GF TP Family #=GF CL CL0063 #=GF RN [1] #=GF RM 9488683 #=GF RT ApbA, the ketopantoate reductase enzyme of Salmonella #=GF RT typhimurium is required for the synthesis of thiamine via the #=GF RT alternative pyrimidine biosynthetic pathway. #=GF RA Frodyma ME, Downs D; #=GF RL J Biol Chem 1998;273:5572-5576. #=GF RN [2] #=GF RM 9721324 #=GF RT The panE gene, encoding ketopantoate reductase, maps at 10 #=GF RT minutes and is allelic to apbA in Salmonella typhimurium. #=GF RA Frodyma ME, Downs D; #=GF RL J Bacteriol 1998;180:4757-4759. #=GF DR INTERPRO; IPR013332; #=GF DR SCOP; 1ks9; fa; #=GF DR SO; 0100021; polypeptide_conserved_region; #=GF CC This is a family of 2-dehydropantoate 2-reductases also known as #=GF CC ketopantoate reductases, EC:1.1.1.169. The reaction catalysed #=GF CC by this enzyme is: (R)-pantoate + NADP(+) <=> 2-dehydropantoate #=GF CC + NADPH. AbpA catalyses the NADPH reduction of ketopantoic acid #=GF CC to pantoic acid in the alternative pyrimidine biosynthetic (APB) #=GF CC pathway [2]. ApbA and PanE are allelic [2]. ApbA, the #=GF CC ketopantoate reductase enzyme is required for the synthesis of #=GF CC thiamine via the APB biosynthetic pathway [1]. #=GF SQ 10935 #=GS R6QWM8_9FIRM/5-148 AC R6QWM8.1 #=GS A0A559J2Z7_9BACL/4-162 AC A0A559J2Z7.1 #=GS I9P4E7_9ALTE/8-147 AC I9P4E7.1 #=GS A0A0N1B799_9PROT/3-172 AC A0A0N1B799.1 #=GS C9ZCV7_STRSW/4-77 AC C9ZCV7.1 #=GS A0A2T5G271_9SPHN/13-180 AC A0A2T5G271.1 #=GS A0A511VCQ2_9BACL/3-150 AC A0A511VCQ2.1 #=GS A0A3T1E163_9GAMM/2-98 AC A0A3T1E163.1 #=GS E1TIX7_BURSG/3-171 AC E1TIX7.1 #=GS A0A364L0B0_9EURO/6-102 AC A0A364L0B0.1 #=GS A0A2H1A6I2_CANAR/35-187 AC A0A2H1A6I2.1 #=GS A0A242K1M4_9ENTE/3-154 AC A0A242K1M4.1 #=GS W9Y026_9EURO/33-197 AC W9Y026.1 #=GS A0A4R5QL94_9PROT/3-172 AC A0A4R5QL94.1 #=GS A0A6G4TUC6_9ACTN/9-151 AC A0A6G4TUC6.1 #=GS A0A4R2BFG5_9BACI/3-150 AC A0A4R2BFG5.1 #=GS A0A1H6BI17_9BACT/6-158 AC A0A1H6BI17.1 #=GS A0A074TAR2_9RHOB/10-163 AC A0A074TAR2.1 #=GS X8AVI2_MYCXE/3-122 AC X8AVI2.1 #=GS D6XTL5_BACIE/3-157 AC D6XTL5.1 #=GS A0A164BUF5_9BACI/3-151 AC A0A164BUF5.1 #=GS A0A0M0KQS5_9BACI/4-150 AC A0A0M0KQS5.1 #=GS B8NFU2_ASPFN/5-180 AC B8NFU2.1 #=GS B1M6W6_METRJ/5-87 AC B1M6W6.1 #=GS R6TGG0_9FIRM/6-150 AC R6TGG0.1 #=GS A1DJ98_NEOFI/7-167 AC A1DJ98.1 #=GS A0A1C7GFC9_9FIRM/10-157 AC A0A1C7GFC9.1 #=GS A0A2N3PP90_9PROT/3-153 AC A0A2N3PP90.1 #=GS A0A418SH13_9RHOB/6-166 AC A0A418SH13.1 #=GS A0A0Q8LXC2_9MICO/8-160 AC A0A0Q8LXC2.1 #=GS A0A2N6NY79_BEABA/89-268 AC A0A2N6NY79.1 #=GS A0A1P8JQD5_9BURK/9-177 AC A0A1P8JQD5.1 #=GS A0A257GX69_9BURK/3-157 AC A0A257GX69.1 #=GS A0A542JCF8_9MICO/6-160 AC A0A542JCF8.1 #=GS F9DPL1_9BACL/3-150 AC F9DPL1.1 #=GS A0A1Y2IQ84_PYCCO/71-189 AC A0A1Y2IQ84.1 #=GS A0A2W4CHT9_9RHIZ/5-153 AC A0A2W4CHT9.1 #=GS A0A5J6PI35_9BACI/3-146 AC A0A5J6PI35.1 #=GS A0A1G5HQS3_9FIRM/8-156 AC A0A1G5HQS3.1 #=GS A0A3A6TRU6_9GAMM/14-166 AC A0A3A6TRU6.1 #=GS A4VL45_PSEU5/8-158 AC A4VL45.1 #=GS A0A1M2VU56_TRAPU/12-179 AC A0A1M2VU56.1 #=GS E1T9P4_BURSG/3-152 AC E1T9P4.1 #=GS A0A1Z5TSQ3_HORWE/124-282 AC A0A1Z5TSQ3.1 #=GS A0A2R8BB65_9RHOB/3-152 AC A0A2R8BB65.1 #=GS V5GC76_BYSSN/10-162 AC V5GC76.1 #=GS A0A3A9JXK6_9PROT/5-153 AC A0A3A9JXK6.1 #=GS A0A2Y9A8C3_9RHOB/3-153 AC A0A2Y9A8C3.1 #=GS A6R3Z5_AJECN/11-166 AC A6R3Z5.1 #=GS A0A5N8V9P2_9ACTN/8-151 AC A0A5N8V9P2.1 #=GS E6SMY0_BACT6/3-175 AC E6SMY0.1 #=GS A0A1Y2D4Z2_9FUNG/9-117 AC A0A1Y2D4Z2.1 #=GS A0A6B2UXN6_9ACTN/18-164 AC A0A6B2UXN6.1 #=GS A0A1N6GD89_9BRAD/3-153 AC A0A1N6GD89.1 #=GS A0A101T5M9_9ACTN/1-145 AC A0A101T5M9.1 #=GS A0A1H4EZC8_ALKAM/1-145 AC A0A1H4EZC8.1 #=GS A0A662Y8M6_9STRA/129-272 AC A0A662Y8M6.1 #=GS A0A1Y3U3Y8_9ACTN/6-154 AC A0A1Y3U3Y8.1 #=GS A1CIW3_ASPCL/8-164 AC A1CIW3.1 #=GS A0A4Z0WA27_9BACT/3-144 AC A0A4Z0WA27.1 #=GS G7DXW7_MIXOS/665-831 AC G7DXW7.1 #=GS A0A3D9UGM7_9GAMM/3-144 AC A0A3D9UGM7.1 #=GS A0A2V1GTV8_9GAMM/16-177 AC A0A2V1GTV8.1 #=GS A0A252DRW6_9NOSO/6-154 AC A0A252DRW6.1 #=GS R6GWC3_9FIRM/3-158 AC R6GWC3.1 #=GS A0A512JPP1_9RHIZ/3-173 AC A0A512JPP1.1 #=GS A0A554XDL2_9BURK/34-181 AC A0A554XDL2.1 #=GS A0A1M5VJ09_9ACTN/3-164 AC A0A1M5VJ09.1 #=GS A0A3G9JCH2_9FIRM/7-152 AC A0A3G9JCH2.1 #=GS A0A6G1X739_9BACI/3-152 AC A0A6G1X739.1 #=GS A0A1H4AS62_9DELT/3-151 AC A0A1H4AS62.1 #=GS A0A1A1Y5Y2_9MYCO/5-149 AC A0A1A1Y5Y2.1 #=GS A0A1M4XAS2_9RHIZ/3-150 AC A0A1M4XAS2.1 #=GS A0A1A5XMH7_9BACL/3-153 AC A0A1A5XMH7.1 #=GS Q0CJV5_ASPTN/461-611 AC Q0CJV5.1 #=GS A0A1M7RIK5_9ACTN/4-161 AC A0A1M7RIK5.1 #=GS I4WWD4_9GAMM/1-152 AC I4WWD4.1 #=GS A0A370QNI5_9ENTR/3-143 AC A0A370QNI5.1 #=GS H1VC87_COLHI/32-193 AC H1VC87.1 #=GS K0KVV0_WICCF/7-174 AC K0KVV0.1 #=GS Q2U214_ASPOR/7-171 AC Q2U214.1 #=GS A0A0M8W6G0_9ACTN/3-161 AC A0A0M8W6G0.1 #=GS M7TC79_EUTLA/9-161 AC M7TC79.1 #=GS A0A0S2K663_9GAMM/3-151 AC A0A0S2K663.1 #=GS M2SXN5_COCH5/46-235 AC M2SXN5.1 #=GS A0A0N1HFE9_9EURO/49-246 AC A0A0N1HFE9.1 #=GS A0A4T0QLL1_9BASI/19-171 AC A0A4T0QLL1.1 #=GS A0A2H3H1L5_FUSOX/10-180 AC A0A2H3H1L5.1 #=GS A0A4R6NMI2_9RHIZ/11-162 AC A0A4R6NMI2.1 #=GS A0A1I4E0F2_9RHIZ/8-159 AC A0A1I4E0F2.1 #=GS D2Q968_BIFDB/3-153 AC D2Q968.1 #=GS A0A518GWF4_9BACT/3-153 AC A0A518GWF4.1 #=GS A9BUX6_DELAS/13-181 AC A9BUX6.1 #=GS F4CIY7_PSEUX/5-167 AC F4CIY7.1 #=GS A0A4R0YG00_9PROT/5-160 AC A0A4R0YG00.1 #=GS A0A1W2CBT7_9FIRM/4-151 AC A0A1W2CBT7.1 #=GS A0A1K1NAL2_9GAMM/3-154 AC A0A1K1NAL2.1 #=GS A0A395S2P1_FUSSP/10-173 AC A0A395S2P1.1 #=GS F9PIA8_9ACTO/13-141 AC F9PIA8.1 #=GS A0A1Q8S3G9_9PEZI/15-171 AC A0A1Q8S3G9.1 #=GS A0A089IMB0_9BACL/3-162 AC A0A089IMB0.1 #=GS A0A1J4NLT1_9ACTN/10-153 AC A0A1J4NLT1.1 #=GS A0A167CG35_9ASCO/6-176 AC A0A167CG35.1 #=GS A0A5K1IRV1_9ACTN/3-154 AC A0A5K1IRV1.1 #=GS A0A2S4L8I8_9HYPO/10-168 AC A0A2S4L8I8.1 #=GS A0A1Y1SC79_9GAMM/4-157 AC A0A1Y1SC79.1 #=GS A0A0Q4XF62_9RHIZ/3-155 AC A0A0Q4XF62.1 #=GS A0A1S8DJL9_9PSED/8-157 AC A0A1S8DJL9.1 #=GS A0A257JXC3_9BURK/21-134 AC A0A257JXC3.1 #=GS A0A1Z5I945_9LACO/3-156 AC A0A1Z5I945.1 #=GS F9FWI6_FUSOF/391-542 AC F9FWI6.1 #=GS A0A1J4KIE4_9EUKA/3-153 AC A0A1J4KIE4.1 #=GS A0A1E3PDL6_9ASCO/4-141 AC A0A1E3PDL6.1 #=GS A0A1I0VU42_9FIRM/7-150 AC A0A1I0VU42.1 #=GS M5UBG8_9BACT/13-162 AC M5UBG8.1 #=GS A0A0N0ZFL7_9BURK/4-156 AC A0A0N0ZFL7.1 #=GS A0A1B8GQD6_9PEZI/10-171 AC A0A1B8GQD6.1 #=GS A0A4U1L1F9_9SPHN/7-155 AC A0A4U1L1F9.1 #=GS A0A098QVY9_9SPIO/70-208 AC A0A098QVY9.1 #=GS A0A0J6STR7_9RHIZ/11-154 AC A0A0J6STR7.1 #=GS A0A1Z4HRH4_9NOSO/6-154 AC A0A1Z4HRH4.1 #=GS A0A162IBJ7_9HYPO/8-74 AC A0A162IBJ7.1 #=GS H6C1E8_EXODN/129-232 AC H6C1E8.1 #=GS A0A3G9MFK8_RHOOP/3-153 AC A0A3G9MFK8.1 #=GS A0A0R1YIX0_9LACO/3-155 AC A0A0R1YIX0.1 #=GS A0A0B6S760_BURPL/3-153 AC A0A0B6S760.1 #=GS A0A1Q9CNS9_SYMMI/64-225 AC A0A1Q9CNS9.1 #=GS A0A127VWM8_SPOPS/3-152 AC A0A127VWM8.1 #=GS A0A0D2PWG4_HYPSF/8-174 AC A0A0D2PWG4.1 #=GS A0A5C3FA13_9BASI/14-176 AC A0A5C3FA13.1 #=GS A0A2S8K965_9DELT/12-162 AC A0A2S8K965.1 #=GS A0A4U0XI16_9PEZI/16-172 AC A0A4U0XI16.1 #=GS A0A1X7M7N6_9BURK/3-171 AC A0A1X7M7N6.1 #=GS A0A075JPN5_9BACI/3-145 AC A0A075JPN5.1 #=GS A0A143XK71_9FIRM/7-152 AC A0A143XK71.1 #=GS A0A4T9WCE9_9FIRM/6-152 AC A0A4T9WCE9.1 #=GS A0A437Q8D2_9GAMM/3-152 AC A0A437Q8D2.1 #=GS A0A0C3NWB7_PHLGI/30-193 AC A0A0C3NWB7.1 #=GS A0A1B9IDZ0_9TREE/17-176 AC A0A1B9IDZ0.1 #=GS A0A370TC47_9HELO/59-227 AC A0A370TC47.1 #=GS A0A1M7MXS5_9BACI/3-153 AC A0A1M7MXS5.1 #=GS A0A2N0J1V8_9ACTN/16-169 AC A0A2N0J1V8.1 #=GS A0A397SIK0_9GLOM/4-186 AC A0A397SIK0.1 #=GS A0A4R3A3R6_9RHIZ/6-149 AC A0A4R3A3R6.1 #=GS A0A1I6T7X6_9BACL/3-158 AC A0A1I6T7X6.1 #=GS A0A099CT03_9GAMM/8-158 AC A0A099CT03.1 #=GS G2LGW1_CHLTF/6-154 AC G2LGW1.1 #=GS A0A1W6ZNM3_9RHIZ/7-178 AC A0A1W6ZNM3.1 #=GS A0A0J1FXU7_9BURK/4-156 AC A0A0J1FXU7.1 #=GS A0A327KE11_9RHIZ/8-150 AC A0A327KE11.1 #=GS A0A4P9ZC38_9ASCO/4-158 AC A0A4P9ZC38.1 #=GS A0A1I6MPT2_9MICO/4-158 AC A0A1I6MPT2.1 #=GS A0A6A7M1Y0_9PROT/3-152 AC A0A6A7M1Y0.1 #=GS A0A1H8CGH2_9BACI/7-152 AC A0A1H8CGH2.1 #=GS A0A1M5I242_9FLAO/5-159 AC A0A1M5I242.1 #=GS A0A0G4L6L6_9PEZI/1-124 AC A0A0G4L6L6.1 #=GS A0A329MJM5_9BACL/20-177 AC A0A329MJM5.1 #=GS A0A3M8K6U8_9CORY/3-148 AC A0A3M8K6U8.1 #=GS A0A1H3Z2T3_9BACI/3-153 AC A0A1H3Z2T3.1 #=GS A0A0D2HDW3_9EURO/7-165 AC A0A0D2HDW3.1 #=GS A0A2G4F3Y9_9CYAN/8-156 AC A0A2G4F3Y9.1 #=GS A0A3L8AE06_9BACE/3-153 AC A0A3L8AE06.1 #=GS A0A4V1K3C1_9BACT/3-106 AC A0A4V1K3C1.1 #=GS A0A1Q5L9E0_9ACTN/19-163 AC A0A1Q5L9E0.1 #=GS A0A4R8XRV4_9MICO/3-148 AC A0A4R8XRV4.1 #=GS A0A1H6CNC8_9ACTN/3-171 AC A0A1H6CNC8.1 #=GS A0A2N4YHZ3_9RHOB/6-158 AC A0A2N4YHZ3.1 #=GS G0S4B2_CHATD/7-194 AC G0S4B2.1 #=GS A0A284RBN8_ARMOS/3-176 AC A0A284RBN8.1 #=GS A0A1I2B8T4_9BACI/3-154 AC A0A1I2B8T4.1 #=GS A0A4S3JQQ1_9EURO/24-219 AC A0A4S3JQQ1.1 #=GS A0A1X7LXG5_9BURK/3-153 AC A0A1X7LXG5.1 #=GS A0A1G9D874_9ACTN/2-152 AC A0A1G9D874.1 #=GS A0A126Z1D8_9MICO/3-167 AC A0A126Z1D8.1 #=GS A0A0A2VFD1_BEABA/156-313 AC A0A0A2VFD1.1 #=GS M2Y5M1_GALSU/4-178 AC M2Y5M1.1 #=GS A0A1I0G0M6_9BACL/3-163 AC A0A1I0G0M6.1 #=GS A0A1M4XWA4_9BACL/3-153 AC A0A1M4XWA4.1 #=GS Q12R68_SHEDO/15-174 AC Q12R68.1 #=GS A0A0R2GSC4_9LACO/3-156 AC A0A0R2GSC4.1 #=GS A0A2U1JVQ9_9BACI/3-153 AC A0A2U1JVQ9.1 #=GS A0A080MB99_9PROT/3-151 AC A0A080MB99.1 #=GS A0A2W2CY57_9ACTN/3-171 AC A0A2W2CY57.1 #=GS 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