LinkDB: ApbA
Original site: ApbA
Chemical reaction (1) KEGG ENZYME (1) Gene (109187) KEGG GENES (109187) Protein sequence (37242) UniProt (37202) SWISS-PROT (40) 3D Structure (15) PDB (14) SCOP (1) Protein domain (2) InterPro (1) NCBI-CDD (1) Literature (2) PubMed (2) All databases (146449)
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#=GF ID ApbA #=GF AC PF02558.16 #=GF DE Ketopantoate reductase PanE/ApbA #=GF AU Bashton M;0000-0002-6847-1525 #=GF AU Bateman A;0000-0002-6982-4660 #=GF SE COGs #=GF GA 22.20 22.20; #=GF TC 22.20 22.20; #=GF NC 22.10 22.10; #=GF BM hmmbuild HMM.ann SEED.ann #=GF SM hmmsearch -Z 45638612 -E 1000 --cpu 4 HMM pfamseq #=GF TP Family #=GF RN [1] #=GF RM 9488683 #=GF RT ApbA, the ketopantoate reductase enzyme of Salmonella #=GF RT typhimurium is required for the synthesis of thiamine via the #=GF RT alternative pyrimidine biosynthetic pathway. #=GF RA Frodyma ME, Downs D; #=GF RL J Biol Chem 1998;273:5572-5576. #=GF RN [2] #=GF RM 9721324 #=GF RT The panE gene, encoding ketopantoate reductase, maps at 10 #=GF RT minutes and is allelic to apbA in Salmonella typhimurium. #=GF RA Frodyma ME, Downs D; #=GF RL J Bacteriol 1998;180:4757-4759. #=GF DR INTERPRO; IPR013332; #=GF DR SCOP; 1ks9; fa; #=GF DR SO; 0100021; polypeptide_conserved_region; #=GF CC This is a family of 2-dehydropantoate 2-reductases also known as #=GF CC ketopantoate reductases, EC:1.1.1.169. The reaction catalysed #=GF CC by this enzyme is: (R)-pantoate + NADP(+) <=> 2-dehydropantoate #=GF CC + NADPH. AbpA catalyses the NADPH reduction of ketopantoic acid #=GF CC to pantoic acid in the alternative pyrimidine biosynthetic (APB) #=GF CC pathway [2]. ApbA and PanE are allelic [2]. ApbA, the #=GF CC ketopantoate reductase enzyme is required for the synthesis of #=GF CC thiamine via the APB biosynthetic pathway [1]. #=GF SQ 9743 #=GS A0A1Q3YSK0_9BURK/9-155 AC A0A1Q3YSK0.1 #=GS I9P4E7_9ALTE/8-147 AC I9P4E7.1 #=GS A0A0N1B799_9PROT/3-172 AC A0A0N1B799.1 #=GS R5JGB0_9BACE/3-153 AC R5JGB0.1 #=GS A0A0P7XC83_9ALTE/16-162 AC A0A0P7XC83.1 #=GS E1TIX7_BURSG/3-171 AC E1TIX7.1 #=GS A0A2H1A6I2_CANAR/35-187 AC A0A2H1A6I2.1 #=GS A0A242K1M4_9ENTE/3-154 AC A0A242K1M4.1 #=GS W9Y026_9EURO/33-197 AC W9Y026.1 #=GS A0A2H3SMT8_FUSOX/6-165 AC A0A2H3SMT8.1 #=GS U2HFM4_9BURK/12-155 AC U2HFM4.1 #=GS A0A1G3EBS8_9GAMM/7-157 AC A0A1G3EBS8.1 #=GS A0A0P1H295_9RHOB/31-195 AC A0A0P1H295.1 #=GS A0A074TAR2_9RHOB/10-163 AC A0A074TAR2.1 #=GS A0A162RBZ0_9CLOT/3-30 AC A0A162RBZ0.1 #=GS D6XTL5_BACIE/3-157 AC D6XTL5.1 #=GS A0A0G2GWA3_9PEZI/14-168 AC A0A0G2GWA3.1 #=GS A0A0M0KQS5_9BACI/4-150 AC A0A0M0KQS5.1 #=GS B8NFU2_ASPFN/5-180 AC B8NFU2.1 #=GS R6TGG0_9FIRM/6-150 AC R6TGG0.1 #=GS A1DJ98_NEOFI/7-167 AC A1DJ98.1 #=GS A0A1H8FU61_9MICO/1-144 AC A0A1H8FU61.1 #=GS K6UA59_9CLOT/8-139 AC K6UA59.1 #=GS J9YFL9_LEUGJ/3-153 AC J9YFL9.1 #=GS A0A0Q8LXC2_9MICO/8-160 AC A0A0Q8LXC2.1 #=GS A0A2H3SN23_FUSOX/8-167 AC A0A2H3SN23.1 #=GS A0A1P8JQD5_9BURK/9-177 AC A0A1P8JQD5.1 #=GS A0A257GX69_9BURK/3-157 AC A0A257GX69.1 #=GS A0A1F8MBP4_9CHLR/3-153 AC A0A1F8MBP4.1 #=GS A0A0T9L7G2_9GAMM/3-143 AC A0A0T9L7G2.1 #=GS F9DPL1_9BACL/3-150 AC F9DPL1.1 #=GS A0A1U9LH88_9PROT/9-152 AC A0A1U9LH88.1 #=GS D6M366_STRSH/9-167 AC D6M366.1 #=GS A4VL45_PSEU5/8-158 AC A4VL45.1 #=GS A0A1M2VU56_TRAPU/12-179 AC A0A1M2VU56.1 #=GS E1T9P4_BURSG/3-152 AC E1T9P4.1 #=GS A0A1Z5TSQ3_HORWE/124-282 AC A0A1Z5TSQ3.1 #=GS B1ZGN8_METPB/3-155 AC B1ZGN8.1 #=GS V5GC76_BYSSN/10-162 AC V5GC76.1 #=GS A6R3Z5_AJECN/11-166 AC A6R3Z5.1 #=GS A0A1Y4CNB6_9ACTN/6-151 AC A0A1Y4CNB6.1 #=GS E6SMY0_BACT6/3-175 AC E6SMY0.1 #=GS A0A0S8BBF1_9PROT/3-152 AC A0A0S8BBF1.1 #=GS A0A167LQE1_9BASI/10-71 AC A0A167LQE1.1 #=GS A0A0H3JAT4_CLOPA/7-152 AC A0A0H3JAT4.1 #=GS A0A1Y2D4Z2_9FUNG/9-117 AC A0A1Y2D4Z2.1 #=GS A0A1N6GD89_9BRAD/3-153 AC A0A1N6GD89.1 #=GS A0A0E9NAU2_9ASCO/5-161 AC A0A0E9NAU2.1 #=GS A0A101T5M9_9ACTN/1-145 AC A0A101T5M9.1 #=GS A0A1H4EZC8_ALKAM/1-145 AC A0A1H4EZC8.1 #=GS D0SIJ9_ACIJU/3-155 AC D0SIJ9.1 #=GS A0A0G2I8U4_9EURO/11-166 AC A0A0G2I8U4.1 #=GS A1CIW3_ASPCL/8-164 AC A1CIW3.1 #=GS A0A0R1Z0V6_9LACO/3-155 AC A0A0R1Z0V6.1 #=GS G7DXW7_MIXOS/665-831 AC G7DXW7.1 #=GS A0A252DRW6_9NOSO/6-154 AC A0A252DRW6.1 #=GS R6GWC3_9FIRM/3-158 AC R6GWC3.1 #=GS A0A1M5VJ09_9ACTN/3-164 AC A0A1M5VJ09.1 #=GS A0A1H4AS62_9DELT/3-151 AC A0A1H4AS62.1 #=GS A0A1A1Y5Y2_9MYCO/5-149 AC A0A1A1Y5Y2.1 #=GS A0A1M4XAS2_9RHIZ/3-150 AC A0A1M4XAS2.1 #=GS A0A1A5XMH7_9BACL/3-153 AC A0A1A5XMH7.1 #=GS I4WWD4_9GAMM/1-152 AC I4WWD4.1 #=GS H1VC87_COLHI/32-193 AC H1VC87.1 #=GS K0KVV0_WICCF/7-174 AC K0KVV0.1 #=GS Q2U214_ASPOR/7-171 AC Q2U214.1 #=GS A0A0M8W6G0_9ACTN/3-161 AC A0A0M8W6G0.1 #=GS M7TC79_EUTLA/9-161 AC M7TC79.1 #=GS A0A1G3CP59_9BURK/3-174 AC A0A1G3CP59.1 #=GS A0A0S2K663_9GAMM/3-151 AC A0A0S2K663.1 #=GS A0A0P6SF49_9STRE/3-151 AC A0A0P6SF49.1 #=GS M2SXN5_COCH5/46-235 AC M2SXN5.1 #=GS A0A1S8YER5_9ENTR/3-143 AC A0A1S8YER5.1 #=GS A0A0N1HFE9_9EURO/49-246 AC A0A0N1HFE9.1 #=GS D2Q968_BIFDB/3-153 AC D2Q968.1 #=GS A9BUX6_DELAS/13-181 AC A9BUX6.1 #=GS F4CIY7_PSEUX/5-167 AC F4CIY7.1 #=GS A0A1W2CBT7_9FIRM/4-151 AC A0A1W2CBT7.1 #=GS A0A1K1NAL2_9GAMM/3-154 AC A0A1K1NAL2.1 #=GS A3CY55_METMJ/9-156 AC A3CY55.1 #=GS A0A1Q8S3G9_9PEZI/15-171 AC A0A1Q8S3G9.1 #=GS A0A158CNX7_9BURK/1-143 AC A0A158CNX7.1 #=GS A0A0F7UZZ5_TOXGV/601-756 AC A0A0F7UZZ5.1 #=GS A0A089IMB0_9BACL/3-162 AC A0A089IMB0.1 #=GS A0A1J4NLT1_9ACTN/10-153 AC A0A1J4NLT1.1 #=GS A0A1U7IX05_9NOSO/3-173 AC A0A1U7IX05.1 #=GS A0A167CG35_9ASCO/6-176 AC A0A167CG35.1 #=GS A0A1D9GKC9_9ALTE/2-145 AC A0A1D9GKC9.1 #=GS J3PK57_GAGT3/141-294 AC J3PK57.1 #=GS A0A1Y1SC79_9GAMM/4-157 AC A0A1Y1SC79.1 #=GS A0A1E4J8P2_9BURK/3-173 AC A0A1E4J8P2.1 #=GS A0A0Q4XF62_9RHIZ/3-155 AC A0A0Q4XF62.1 #=GS A0A257JXC3_9BURK/21-134 AC A0A257JXC3.1 #=GS A0A1Z5I945_9LACO/3-156 AC A0A1Z5I945.1 #=GS F9FWI6_FUSOF/391-542 AC F9FWI6.1 #=GS A0A1E3PDL6_9ASCO/4-141 AC A0A1E3PDL6.1 #=GS A0A1I0VU42_9FIRM/7-150 AC A0A1I0VU42.1 #=GS M5UBG8_9PLAN/13-162 AC M5UBG8.1 #=GS A0A0N0ZFL7_9BURK/4-156 AC A0A0N0ZFL7.1 #=GS A0A066XVH0_9ACTN/3-171 AC A0A066XVH0.1 #=GS A0A1B8GQD6_9PEZI/10-171 AC A0A1B8GQD6.1 #=GS I0TEL7_9BACT/3-138 AC I0TEL7.1 #=GS A0A1T5IFT8_9MICO/3-158 AC A0A1T5IFT8.1 #=GS A0A0C1Z3X8_9BURK/20-166 AC A0A0C1Z3X8.1 #=GS A8U758_9LACT/3-152 AC A8U758.1 #=GS A0A0J6STR7_9RHIZ/11-154 AC A0A0J6STR7.1 #=GS A0A162IBJ7_9HYPO/8-74 AC A0A162IBJ7.1 #=GS V9QSN4_9PSED/8-158 AC V9QSN4.1 #=GS Q8PFB5_XANAC/3-157 AC Q8PFB5.1 #=GS A0A0R1YIX0_9LACO/3-155 AC A0A0R1YIX0.1 #=GS A0A1Q9CNS9_SYMMI/64-225 AC A0A1Q9CNS9.1 #=GS A0A0M8U0V9_9ACTN/3-171 AC A0A0M8U0V9.1 #=GS A0A127VWM8_SPOPS/3-152 AC A0A127VWM8.1 #=GS A0A0D2PWG4_9AGAR/8-174 AC A0A0D2PWG4.1 #=GS A0A151A2F3_STASA/4-140 AC A0A151A2F3.1 #=GS A0A1X7M7N6_9BURK/3-171 AC A0A1X7M7N6.1 #=GS A0A1F4JA48_9BURK/10-183 AC A0A1F4JA48.1 #=GS K9NPG8_9PSED/5-154 AC K9NPG8.1 #=GS A0A075JPN5_9BACI/3-145 AC A0A075JPN5.1 #=GS A0A143XK71_9FIRM/7-152 AC A0A143XK71.1 #=GS A0A0C3NWB7_PHLGI/30-193 AC A0A0C3NWB7.1 #=GS A0A1B9IDZ0_9TREE/17-176 AC A0A1B9IDZ0.1 #=GS I0QSM2_9GAMM/22-170 AC I0QSM2.1 #=GS A0A1M7MXS5_9BACI/3-153 AC A0A1M7MXS5.1 #=GS A0A1I6T7X6_9BACL/3-158 AC A0A1I6T7X6.1 #=GS G2LGW1_CHLTF/6-154 AC G2LGW1.1 #=GS A0A1I3XNC0_HALDA/3-153 AC A0A1I3XNC0.1 #=GS A4IKQ5_GEOTN/3-152 AC A4IKQ5.1 #=GS A0A1G7CB68_9RHOB/3-157 AC A0A1G7CB68.1 #=GS A0A1Q7E8T0_9CHLR/28-125 AC A0A1Q7E8T0.1 #=GS A0A1W6ZNM3_9RHIZ/7-178 AC A0A1W6ZNM3.1 #=GS A0A0J1FXU7_9BURK/4-156 AC A0A0J1FXU7.1 #=GS A0A1I6MPT2_9MICO/4-158 AC A0A1I6MPT2.1 #=GS A0A1H8CGH2_9BACI/7-152 AC A0A1H8CGH2.1 #=GS A0A0G4L6L6_9PEZI/1-124 AC A0A0G4L6L6.1 #=GS A0A1H3Z2T3_9BACI/3-153 AC A0A1H3Z2T3.1 #=GS A0A1Y6HHX8_9XANT/3-157 AC A0A1Y6HHX8.1 #=GS A0A0D2HDW3_9EURO/7-165 AC A0A0D2HDW3.1 #=GS A0A2G4F3Y9_9CYAN/8-156 AC A0A2G4F3Y9.1 #=GS E6UYF8_VARPE/9-159 AC E6UYF8.1 #=GS A0A1Q5L9E0_9ACTN/19-163 AC A0A1Q5L9E0.1 #=GS G0S4B2_CHATD/7-194 AC G0S4B2.1 #=GS A0A284RBN8_9AGAR/3-176 AC A0A284RBN8.1 #=GS A0A1I2B8T4_9BACI/3-154 AC A0A1I2B8T4.1 #=GS A0A1X7LXG5_9BURK/3-153 AC A0A1X7LXG5.1 #=GS A0A1G9D874_9ACTN/2-152 AC A0A1G9D874.1 #=GS A0A126Z1D8_9MICO/3-167 AC A0A126Z1D8.1 #=GS A0A0A2VFD1_BEABA/156-313 AC A0A0A2VFD1.1 #=GS M2Y5M1_GALSU/4-178 AC M2Y5M1.1 #=GS A0A1I0G0M6_9BACL/3-163 AC A0A1I0G0M6.1 #=GS A0A1M4XWA4_9BACL/3-153 AC A0A1M4XWA4.1 #=GS Q12R68_SHEDO/15-174 AC Q12R68.1 #=GS A0A144YCX0_9BURK/9-152 AC A0A144YCX0.1 #=GS A0A0R2GSC4_9LACO/3-156 AC A0A0R2GSC4.1 #=GS A0A0Q4ZEB5_9RHIZ/3-174 AC A0A0Q4ZEB5.1 #=GS A0A080MB99_9PROT/3-151 AC A0A080MB99.1 #=GS A0A0N7JFD2_9SPHI/7-163 AC A0A0N7JFD2.1 #=GS J8VXG2_9PORP/6-160 AC J8VXG2.1 #=GS A0A0Q5AI74_9MICO/5-162 AC A0A0Q5AI74.1 #=GS A0A1I4W8S0_9ALTE/2-146 AC A0A1I4W8S0.1 #=GS A0A1L9T1X6_9EURO/6-162 AC A0A1L9T1X6.1 #=GS A0A1I3XNN4_9PROT/14-183 AC A0A1I3XNN4.1 #=GS A4JN60_BURVG/18-168 AC A4JN60.1 #=GS S8AC13_DACHA/8-164 AC S8AC13.1 #=GS A0A196Q214_9RHOB/8-160 AC A0A196Q214.1 #=GS A0A101FQS8_9FIRM/3-154 AC A0A101FQS8.1 #=GS A0A0A8DYD3_9XANT/3-157 AC A0A0A8DYD3.1 #=GS A0A1X0Y220_9DELT/11-163 AC A0A1X0Y220.1 #=GS A0A0F3L197_9GAMM/3-154 AC A0A0F3L197.1 #=GS A0A077LIB9_9PSED/4-154 AC A0A077LIB9.1 #=GS A0A0C5WKX6_9GAMM/6-156 AC A0A0C5WKX6.1 #=GS Q18CT0_PEPD6/12-156 AC Q18CT0.1 #=GS A0A1F8NQ26_9CHLR/6-153 AC A0A1F8NQ26.1 #=GS E8W5T6_STRFA/11-160 AC E8W5T6.1 #=GS A0A0Q4UMI4_9MICO/3-156 AC A0A0Q4UMI4.1 #=GS A0A1B2QXT9_9BORD/3-152 AC A0A1B2QXT9.1 #=GS A0A212R5A5_9CHLR/11-162 AC A0A212R5A5.1 #=GS Q5UY68_HALMA/3-144 AC Q5UY68.1 #=GS A0A194XGP7_9HELO/28-203 AC A0A194XGP7.1 #=GS A0A0D5VKM7_9BURK/3-153 AC A0A0D5VKM7.1 #=GS D1BEP2_SANKS/30-181 AC D1BEP2.1 #=GS A0A269PQE0_9GAMM/16-160 AC A0A269PQE0.1 #=GS S2XLR9_9BACL/3-151 AC S2XLR9.1 #=GS E6V2R7_VARPE/3-153 AC E6V2R7.1 #=GS A0A1G7SZK1_9PSED/9-159 AC A0A1G7SZK1.1 #=GS A0A1I3QBX1_9GAMM/3-143 AC A0A1I3QBX1.1 #=GS A0A2A9CW41_9ACTN/3-154 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