GenomeNet

Database: Pfam
Entry: AviRa
LinkDB: AviRa
Original site: AviRa 
#=GF ID   AviRa
#=GF AC   PF11599.11
#=GF DE   RRNA methyltransferase AviRa
#=GF AU   Pollington J;0000-0002-8158-8998
#=GF SE   pdb_1o9g
#=GF GA   25.70 25.70;
#=GF TC   25.70 25.80;
#=GF NC   25.60 25.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF CL   CL0063
#=GF RN   [1]
#=GF RM   12742024
#=GF RT   Crystal structure of the avilamycin resistance-conferring
#=GF RT   methyltransferase AviRa from Streptomyces viridochromogenes. 
#=GF RA   Mosbacher TG, Bechthold A, Schulz GE; 
#=GF RL   J Mol Biol. 2003;329:147-157.
#=GF DR   INTERPRO; IPR024268;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family of proteins represents the methyltransferase AviRa
#=GF CC   from Streptomyces viridochromogenes. This protein mediates the
#=GF CC   resistance to the antibiotic avilamycin. AviRa methylates a
#=GF CC   specific guanine base within the peptidyl-transferase loop of
#=GF CC   the 23S ribosomal RNA [1].
#=GF SQ   79
#=GS A0A1Q9TV68_9ACTN/1-229   AC A0A1Q9TV68.1
#=GS A0A0S4IXA1_BODSA/83-307  AC A0A0S4IXA1.1
#=GS A0A2P8CUW3_9ACTN/1-231   AC A0A2P8CUW3.1
#=GS A0A4Q7V7U4_9PSEU/8-194   AC A0A4Q7V7U4.1
#=GS A0A1C6UV85_9ACTN/1-236   AC A0A1C6UV85.1
#=GS A0A2K2FAS2_9FIRM/1-231   AC A0A2K2FAS2.1
#=GS A0A1I4SM55_9PSEU/1-190   AC A0A1I4SM55.1
#=GS A0A238YKX9_9ACTN/1-234   AC A0A238YKX9.1
#=GS A0A5B2XG26_9PSEU/1-235   AC A0A5B2XG26.1
#=GS A0A0N7JZF6_9PSEU/1-227   AC A0A0N7JZF6.1
#=GS A0A5C4TI67_9BACL/11-245  AC A0A5C4TI67.1
#=GS A0A3N0E900_9ACTN/1-230   AC A0A3N0E900.1
#=GS A0A1M6NSQ1_9ACTN/1-229   AC A0A1M6NSQ1.1
#=GS A0A3A8YBF5_9BACT/1-230   AC A0A3A8YBF5.1
#=GS A0A543NN87_9ACTN/1-232   AC A0A543NN87.1
#=GS A0A136PPG4_9ACTN/1-233   AC A0A136PPG4.1
#=GS A0A269W5I9_9BACL/1-233   AC A0A269W5I9.1
#=GS A0A2A2YZN3_9ACTN/1-234   AC A0A2A2YZN3.1
#=GS A0A060LXB2_9BACI/1-229   AC A0A060LXB2.1
#=GS A0A6P1TQD5_9FIRM/1-129   AC A0A6P1TQD5.1
#=GS A0A1I5JKD5_9ACTN/1-233   AC A0A1I5JKD5.1
#=GS A0A3B0CFR5_9BACL/3-236   AC A0A3B0CFR5.1
#=GS M3CC20_STRMB/1-235       AC M3CC20.1
#=GS A0A0M8XW25_9ACTN/1-215   AC A0A0M8XW25.1
#=GS D2AWL7_STRRD/1-234       AC D2AWL7.1
#=GS A0A6P1TUR6_9FIRM/1-105   AC A0A6P1TUR6.1
#=GS A0A061P0B3_9BACL/7-236   AC A0A061P0B3.1
#=GS A0A061PHI3_9BACL/1-230   AC A0A061PHI3.1
#=GS R9KK57_9FIRM/2-90        AC R9KK57.1
#=GS A0A4P6Q6L0_9ACTN/1-230   AC A0A4P6Q6L0.1
#=GS A0A4R6V306_9ACTN/1-230   AC A0A4R6V306.1
#=GS A0A1B1ZMM7_9PSEU/1-185   AC A0A1B1ZMM7.1
#=GS A0A6C0FVW6_9BACL/1-237   AC A0A6C0FVW6.1
#=GS D7AX50_NOCDD/1-231       AC D7AX50.1
#=GS A0A0N1NBN1_9ACTN/1-245   AC A0A0N1NBN1.1
#=GS A0A4R4M8E3_9ACTN/1-233   AC A0A4R4M8E3.1
#=GS A0A0M4QLW8_9PSEU/1-190   AC A0A0M4QLW8.1
#=GS A0A429B9G1_9ACTN/1-235   AC A0A429B9G1.1
#=GS A0A151YYY3_9BACL/1-230   AC A0A151YYY3.1
#=GS L0EEW0_THECK/1-237       AC L0EEW0.1
#=GS A0A2V2YVF5_9BACL/1-239   AC A0A2V2YVF5.1
#=GS A9KJB4_LACP7/1-224       AC A9KJB4.1
#=GS A0A223SEA5_9ACTN/1-232   AC A0A223SEA5.1
#=GS V9GBS0_9BACL/1-237       AC V9GBS0.1
#=GS A0A1Y2MXF1_PSEAH/1-234   AC A0A1Y2MXF1.1
#=GS C4RPB1_MICS3/1-235       AC C4RPB1.1
#=GS A0A1R3UKD8_9ACTN/1-228   AC A0A1R3UKD8.1
#=GS G4L5U2_TETHN/1-235       AC G4L5U2.1
#=GS A0A326U6X4_9CHLR/12-244  AC A0A326U6X4.1
#=GS A0A1R1F2M5_9BACL/1-235   AC A0A1R1F2M5.1
#=GS D3EHE3_GEOS4/1-237       AC D3EHE3.1
#=GS A0A1H3SVU9_9BACI/1-232   AC A0A1H3SVU9.1
#=GS A0A1H2ZGU3_9FIRM/1-225   AC A0A1H2ZGU3.1
#=GS A0A0C2G8J6_9ACTN/1-230   AC A0A0C2G8J6.1
#=GS A0A419HR07_9PSEU/1-218   AC A0A419HR07.1
#=GS A0A0H5SGT4_HERHM/1-224   AC A0A0H5SGT4.1
#=GS A0A6I4VWF2_9BACL/1-229   AC A0A6I4VWF2.1
#=GS A0A124H0X9_9ACTN/1-235   AC A0A124H0X9.1
#=GS A0A5C8JSV3_9ACTN/1-235   AC A0A5C8JSV3.1
#=GS D1BGB8_SANKS/1-223       AC D1BGB8.1
#=GS A0A2N0JTU3_9ACTN/1-238   AC A0A2N0JTU3.1
#=GS A0A4V2WPU6_9BACL/1-60    AC A0A4V2WPU6.1
#=GS A0A4Q2LP36_9BACL/1-236   AC A0A4Q2LP36.1
#=GS A0A2T0ML69_9ACTN/1-234   AC A0A2T0ML69.1
#=GS A0A1T5LV92_9CLOT/1-232   AC A0A1T5LV92.1
#=GS A0A560MQQ2_9MICO/1-225   AC A0A560MQQ2.1
#=GS A0A370I5T1_9NOCA/1-227   AC A0A370I5T1.1
#=GS A0A091CDM9_9ENTE/1-233   AC A0A091CDM9.1
#=GS A0A1I1FU39_9FIRM/1-155   AC A0A1I1FU39.1
#=GS A0A4R1HGD8_9PSEU/1-225   AC A0A4R1HGD8.1
#=GS R9KC37_9FIRM/1-97        AC R9KC37.1
#=GS A0A221W1A9_9PSEU/1-195   AC A0A221W1A9.1
#=GS A0A1T4R189_9ACTN/1-230   AC A0A1T4R189.1
#=GS A0A553ZFN0_9ACTN/1-233   AC A0A553ZFN0.1
#=GS A0A343JFC4_9CLOT/1-232   AC A0A343JFC4.1
#=GS W2EII2_9ACTN/1-95        AC W2EII2.1
#=GS A0A317M415_9ACTN/1-229   AC A0A317M415.1
#=GS A0A4P6JK52_9CHLR/1-245   AC A0A4P6JK52.1
#=GS J7LF16_NOCAA/1-228       AC J7LF16.1
A0A1Q9TV68_9ACTN/1-229              ...................MGYRYAVERADHSALAS.GQVLRSAPGYPGFPVRLASE.LFQRGL.AHV--.....HDSP....VRLWDPCCGGG.YLL.TV.LG.LLHRD.R..V...S.HVRASDVDADA..VD.LAARNLELLTASGLATREAELRRSARDF..GRVAF.VERAEAAANLAAGL....AA..MGGDLPHDAAVAD...VF...A.LG.EPVG..--.........ADLVVTDVPYGEMTRWSGGv......pGEDP..VGALLASL...GRVL-PERAVVVVAARTRRIALPEG...VRALERVRVGNR..........................................................
A0A0S4IXA1_BODSA/83-307             .....lemykrfpqeydll-----------------.-----MAKHDCTQLNRLFGD.LMEDVR.QRLRS.....AEHG....LRMIDLGCGTG.RLL.CAaLS.EAAAR.RipL...S.LLIGYDKEAAM..LR.IALANMQKQQ-QQQQRRESEPDAVDSRE..ATETI.TEALQSIDRAEDWS....SS..SSGTTTTCLRPFD...FL...H.VR.QGAL..HAphp...thhIAVCAWSLSYVMRSCWGGD.......rWHQE..LRDTVDAI...VASVVDGGAVVII------------...------------etlgngcetptrrnvm..........................................
A0A2P8CUW3_9ACTN/1-231              ...................MSYRHAIERIDHSDLAS.GQVLHSAPGHPGFPVRLASE.LFQRAA.ALLPG.....TGP-....AALWDPCCGSG.YLA.AV.VG.LLHRD.R..V...A.HVLATDVDPGA..AA.LAGRNLALLTGAGLAAREAELRARAAEF..GKPSY.AATADSAARLAGRL....AA..AGGDLAHEARTGD...VF...A.PV.APAV..P-.........VDVVLTDVPYGALTHWAGAv......pAGDP..VAVLLTGV...AGVL-PGHAVLAVAARARRVAVPDG...VPALGRVRVGNR..........................................................
A0A4Q7V7U4_9PSEU/8-194              .........vqyrhapgan--------------FADlDAVLASAPGRPSLPVRLTLE.LFGRCH.EQLGD.....PGP-....VVVWDPCCGTG.QLL.TT.LG.LLRRD.E..V...A.ALVGSDADPEP..LA.LAARNLALLTPGGAEARAAELDALAWQH..GKPGY.SDAAAAARRLDPAR....--..EGPPSE--VTVAD...AFdpaAtGG.IVAR..HR.........PMVVLADLPYGRQTNWAGR........AAAP..Q-------...-------------------------...------------pda.......................................................
A0A1C6UV85_9ACTN/1-236              ...................MTYRFVAERHDYSDLAS.GAVLRSAPGHPAFPVRLASE.VFLRAW.HALGQ.....SRP-....LTVWDPCCGGG.YLL.TV.LG.LLHRD.K..I...A.AVVASDIADGP..LR.LARANLALLSAEGMRRRTAELEDLARRF..GRPSY.RESAEASRRLQALL....AQ..GGGDLPYVVGAAD...AL...D.QQ.QVSA..LLta....sppPGLVLTDLPYGEQTSWRGA.......pQEAG..LSGLLGTL...GSVL-PADAMVALTTRGRRVGLPAG...VRATARFKIGTR..........................................................
A0A2K2FAS2_9FIRM/1-231              ...................MEYKY-CSNDNFEDFAC.GRVIYNKAGMPNFPVRLSQE.IFGRCL.SYLKN.....EKD-....ICIYDPCCGSG.YML.TV.LG.LLNMD.S..I...N.KIIGSDIDIEA..VT.MAKQNLSLLTEEGMKARIQQLEDLYGRF..HKASH.EAAIQSANHIMNML....RE..HPDKPTTFVFQAD...VL...S.ED.VLKD..RNf.......kADIVMTDVPYGNLASWQGS........EDDI..MGMLLENL...IPVL-KPDSVVAICSDKKQKIKNDK...YQRLEKHQIGKR..........................................................
A0A1I4SM55_9PSEU/1-190              ...................MQYRHAPAADR---SAL.DAVLASAPGRPTLPVRLTVE.LLGRAR.EHLAS.....RGAGnpgpVTVWDPCCGAG.VSL.TV.LG.LLCP-.G..I...A.TLAGTDADPAP..LD.LARRNLALLAPGGPAARASELDDLATRH..GKESY.ADAAAAARELVPRS....RP..QWMVAPADAHDRA...AT...R.AA.-LAG..IA.........PDVVLADLPHGRQTSWAGA........TAAP..A-------...-------------------------...------------tpa.......................................................
A0A238YKX9_9ACTN/1-234              ...................MAYRYAVVRQNHEDLAS.GGVLHSAPGFPAFPVRLASE.MFQRAL.ALLRE.....DEA-....-TVWDPCCGSG.YLL.TV.LG.LLHHR.Q..I...T.AVLGTDVDTEA..LR.LAAQNLSLLDEAGLTARAADLDARAERW..DKPSY.AAPARAARRLAREL....RT..GRGGVGHAVRPAD...VF...D.PE.QLR-..-Rald...garPGLVITDVPYGEQTDWRGP.......gGASG..VAGMLRAL...GAVL-PEEAVIAVAVRGRRLRLDDG...LRADSSFRIGTR..........................................................
A0A5B2XG26_9PSEU/1-235              ...................MTYRYAVDRVDRTDLAS.GSVLRSAPGFPAFPVRLASE.VFQRAA.ALRGS.....AGR-....LTVWDPCCGSG.YLL.TV.LG.LLHRD.R..I...G.AVLGSDAAEAA..LP.LAGANLGLLLAGGLRARQRELAALADAH..GRPSH.LAAVAAAGRLADEV....EA..AGEDPEVVTATAD...VF...R.PD.RLAE..ALag.....rsPDLVITDVPYGDQTEWSGAp......aGVEP..LPAMLTSV...ASVL-PADAVLAVACRARRVPLGG-...LPRIGSLRVGTR..........................................................
A0A0N7JZF6_9PSEU/1-227              ...................MQYRHAPAAN---HAAL.DAVLVSAPGRPTLPVRLTVE.LAGRAR.ERL-G.....P--G...pVTVWDPCCGAG.VSL.AV.LG.LLCP-.G..I...A.VLAGTDADPAP..LG.LARRNLGLLAPGGLDDRASTLDGLAARH..GKESC.AVAAAAARATIPAS....--..---RPEWRVGVAD...AG...-.-D.PEAV..RTalg...giePDLVLADLPHGRQTSWAGEp.....gtGPPP..EAGFLVAV...AEPL-HAEAVVVAVGRGRSVPLPPG...VRPLERIRAGHR..........................................................
A0A5C4TI67_9BACL/11-245             ..................v-SYQFATEYENYEDLAS.GRVLYNQHGSTAFPVRLASE.LFQRGK.AILSG.....KGSRg..pYRIYDPCCGGA.YML.AS.IG.FLHGE.D..I...E.SIAASDIDPSA..VD.LACRNLSLLTAEGLRKRVEQIEQMHDSY..GKQSH.AEALAGAERLRQRI...gSF..PKSAGISECFAAD...AT...Q.PN.ERLK..GK........rFDIVLTDVPYGNKVEWNTE........ASDP..AGLLLDRL...EPVL-APASVVILVSAKDFKITHVR...YRRLGQYKIGKR..........................................................
A0A3N0E900_9ACTN/1-230              ...................MAYRYATERVDHTDLAS.GYVLRSVPGQPGFPARLASE.LFQRSL.AHLD-.....ADP-....VGLWDPCCGGG.HLA.AV.LA.LLHRD.R..L...A.HVHASDVDGDS..VR.IAARNLDLLTERGMAERERELRAGAVEF..AKPAF.SDRAEAARRLAEWL....RS..RGGDLRHSVWEAD...AF...A.PV.PPER..-R.........VDLVLTDVPYGNLAHWAGAr......pAGDE..VHALLRAL...SGVL-PAEAVLTVTARARRVDLPRG...VRALERVRVGNR..........................................................
A0A1M6NSQ1_9ACTN/1-229              ...................MTYRYAVDRADGSVLAS.GHVLRSAPGFPGFPVRLASE.LFQRAA.VHVGD.....T--R....VRLWDPCCGSG.YLA.AV.LG.LLHRE.R..I...A.SVRATDVDPDA..VE.LAGRNLRLLTAEGLAEREEELRRSARDF..GRPAF.VERARDARALARGL....AR..DGGDLPHEAAVAD...VF...S.AV.EPVA..--.........ADLVVTDVPYGEMTRWSGAa......pEADP..VGGLLAAL...GRVL-PPGAVIVVAARARRIALPEG...VRALERVKVGVR..........................................................
A0A3A8YBF5_9BACT/1-230              ...................MVYKY-CENKNFEDLAS.GKVIAHKSGYPNFPVRLAQE.IFSRCL.HYLDN.....PGS-....ICIYDPCCGGG.YLL.AV.LG.FLNYE.K..I...D.TIIASDINEEA..VQ.LAAENLSLLTKNGLNQRIQQLKHYLSLH..NKSSH.KEALDSAANLLSIL....TN..SAHEIGYKVFQTN...IL...S.DC.PFDT..QTf.......kADIIFTDVPYGNLVKWQHK........NEDN..I-NLLEQL...LPVA-KDGAIVAVCSDKSQKFQSDY...FQRLEKQVIGKR..........................................................
A0A543NN87_9ACTN/1-232              ...................MGYRYARQRADHTDLAQ.GCVLRSAPGYPGFPVRFASE.LLQRAA.ARVEH.....DGP-....VGMWDPCCGSG.YLA.TV.LG.LLHRE.R..L...A.RVLASDVDADA..VA.VAERNLDLLAEGGLRRRERELRADAERF..GKPAL.TERAEAARRLAGRF....SR..AGGALPAVVRRQD...AF...A.PD.PPDV..P-.........VDVVLTDVPYGGLSQWRGLa.....paETEP..AVSLMAAL...ASVL-PGGAVVGVTARTRKVPLPAG...VSPLERVRVGNR..........................................................
A0A136PPG4_9ACTN/1-233              ...................MTYRFATERPDYSDLAS.GAVLRSAPGHPAFPVRLASE.MFLRAW.HALGR.....PR--....VTVWDPCCGSG.YLL.TV.LG.LLHRE.R..I...A.GIVASDVADGP..LR.LARANLGLLSADGLQDRAAELDELADRF..QRPAH.RTAAEAARRLRAQL....--..TPGDPATVVGRAD...AL...V.PE.QVAD..LLaa....sgpPDLVLTDVPYGEQTTWQGA.......dPAAG..LPGLLDSL...AGAL-PAETMVALATRGRRVPLPAG...TRTAARFKIGTR..........................................................
A0A269W5I9_9BACL/1-233              ...................MEYIYESAQRSYEDFAS.GRVLYNARGTTSFPVRLASE.IVQRCL.RMLED.....RGNEg..pYTLFDPCCGGG.YLL.TV.AG.LLHGQ.R..F...K.QVIGSDVNAGV..LE.LAGNNLSLLTPEGMQRREKQIKELIQLY..DKPSH.HEALQSVARLEQLL....-D..RSAIEEVRCFQGD...IT...N.WQ.EPFD..LK.........ANLVLTDLPYGQIVSWNGD........SADP..VHDFFEHV...YRLLEPGRAVVAVIADKSQKLRHDR...FTKIQGFKVGKR..........................................................
A0A2A2YZN3_9ACTN/1-234              ...................MPYRHATERVDSTDLAC.GVVLHSAPGYPAFPVRLAVE.IFLRGL.DHLPD.....DGP-....VTLWDPCCGSG.YLV.TV.LG.LLQRR.S..L...R.RVIASDVDPEP..VG.LARKNLALLTPEGLAARERERREQSERF..AKPSY.LEAADAARRLRERL....TA..DGGGLPCTVETAD...VF...D.AE.ALAR..VVsg.....spPDLVVTDLPYGERTQWAGE.......vPGEP..VTGMLRSL...ASVL-PPHAVIAVTDRARKIPVAP-...VRPLERLKIGTR..........................................................
A0A060LXB2_9BACI/1-229              ...................MQFTYETIKRDFSDFSS.GRVLYNAPGSTGFPIRLTSE.IFQISR.SYLQK.....PSQ-....LNVYDPCCGGA.HLL.TG.IG.FLHGG.S..I...Q.TLYGSDSNETI..IE.TGQSNLRLLTYEGLAQRKRKLEKDYLLF..NKSAH.AEALKSVDRLKSYL....D-..KTGEVKGEIFQFN...IA...S.KD.VPKL..EE.........IHIVMTDLPYGELVSWDTN........VLSP..VKQMLQNV...YSVL-AHDGVVAVVSDKFTLIEHPL...FRRLKVLKHGKR..........................................................
A0A6P1TQD5_9FIRM/1-129              .................mh-----------------.--------------------.------.-----.....----....-----------.---.--.--.-----.-..-...-.-----------..--.----------ADGLNKRMEQIKELAGLY..GKESH.EEAVQSAIRLHKRI....--..ESSNIITRVFTAN...AF...E.S-.LTLS..KT.........PDIIITDVPYGDIVSWEGA........DNGN..VDLLLDSL...YQIC-NNETVIGICMDKSQKNTNEK...FKRLEKQQVGKR..........................................................
A0A1I5JKD5_9ACTN/1-233              ...................MAYRYAVVRENYEDLAS.GGVLHSAPGFPAFPVRLASE.MFQRAL.AMRQD.....HA--....AMVWDPCCGSG.YML.TV.LG.LLHPG.Q..I...T.AVVGTDIDPAA..LR.LAGQNLALLDEAGLSARAADLDAQAERW..DKPSY.AAAAQAARRLARRL....-P..SGQGPAPHLHQAD...VF...D.PR.QLRQ..-Ald....grrPGLVITDVPYGEQTGWRGP.......gGASG..TAGMLRAL...GELL-SEDAVIAVAVRGRKLRLDDG...PRADATFRIGTR..........................................................
A0A3B0CFR5_9BACL/3-236              ..................v-NYRHAVERHSFEDLAS.GRVLYNGRGTTAFPVRLASE.LFSRAA.AYLTG.....RGNAg..pYRLYDPCAGGA.YML.TA.IG.FLHGD.L..I...A.DIAASDIDPQA..VE.LAARNLSLLTAEGLNERVRQLRELYDSY..GKTSH.SEALDSAERLGAII....AS..HPERPATACLAAD...AT...E.PI.GALQ.gRQ.........FDMIVSDLPYGHLVDWTTE........AEHP..ARQMLDRL...APLL-TPVSVVVLVAPKEQKITNDR...YEQVGQFKVGKR..........................................................
M3CC20_STRMB/1-235                  .................ms-SYRHAVERSDSSDLAC.GVVLHSAPGYPAFPVRLATE.IFLRAQ.ARLPD.....DGP-....VTLWDPCCGSG.YLL.TV.LG.LLHRR.A..L...R.RVIASDVDPAP..LE.LAAKNLALLSPGGLAAREAERREQSERF..AKPAY.QESADAARRLRDRL....EA..DGGALPYAVGAAD...VF...D.PR.SLSA..VVag.....aaPDVVLTDLPYGERTHWDGA.......vPGQP..VTGMLRSL...ASVL-PAHAVIAVTDRSRKIPVAP-...VPALERLKIGTR..........................................................
A0A0M8XW25_9ACTN/1-215              ..................m---------------AS.GNVLRSAPGFPGFPVRLASE.LFQRGL.AHVPR.....--EP....VRMWDPCCGSG.YLV.TV.LG.LLHRD.R..I...V.HARATDVDPDA..VA.LAARNLALLTREGLAEREEELRRSALDF..GRAEF.VGRAETAGALAAGL....AS..MGGDLPHETGVAD...VF...T.LS.EPVE..--.........ADLVVTDVPYGDLTHWRGEa......pGDDP..MAALLASL...GRVL-PPHAVIVVTARTRRVVLPPG...VRALERVKVGNR..........................................................
D2AWL7_STRRD/1-234                  ..................m--YRHATVRGDYEDLAS.GAVLHSAPGFPAFPVRLASE.AFQRAL.ALRGG.....GGP-....ATVWDPCCGSG.YLL.TV.IG.LLHRG.R..I...Q.ALLASDVSDDA..LR.LARANLDLLGQAGLSARAGVLREKAERF..AKPSY.AAAAEAAGRIGRML....AA..GGGDVPHDVRRAD...VF...D.PG.QLAE..AAag.....yaPDIVVTDVPYGEQTTWQGP.......gGDSG..VPGMLAAL...APVL-TERAVVVVTARGRKVPLGGR...IRARESFKVGTR..........................................................
A0A6P1TUR6_9FIRM/1-105              ...................MEYRY-SNNKNFEDFAS.GRVIYNYKGITNFPARLAQE.IFGRCL.EYSNK.....KND-....IGIYDCCCGGG.YML.TI.LG.FMNAD.I..I...S.EITGSDINPDA..VT.KAKTT-----------------------..-----.--------------....--..-------------...--...-.--.----..--.........-------------------........----..--------...-------------------------...------------wnycmqtdlin...............................................
A0A061P0B3_9BACL/7-236              ...................MNYKYETENKDYRDFAS.GRVLLNAKKTTAFPIRMASE.IMQHCI.ASLEK.....KES-....LTLYDPCCGGA.HLL.TA.MG.FIHGK.A..I...K.AIYGSDFDRDV..IE.VATTNLSLLTDDGLIKRENQLSSLFNTY..GKESH.KEALESVGRLRSMS....-A..QMTSPIISSFTWD...IT...G.GP.PPVN..EK.........VDIVITDIPYGNTVGWQTT........SSDP..VQDLLGHL...ELIMNKEDSIIAIVSEKKETITHDR...FEKVKTMKHGKR..........................................................
A0A061PHI3_9BACL/1-230              ...................MQFLYETEAGDYRDFAS.GRVLRNAPGTTAFPVRLTSE.ILFRCR.ALIGK.....KTE-....LTIYDPCCGGA.HML.TA.AG.FLHGR.S..I...T.TIVGSDVNSSV..VP.IAKSNVSLLTREGLEDRKQQLQAFFDEF..QKSAH.REALESIERLEQLQ....QK..AGPFHSLQAFDHD...IT...T.S-.PPSV..EG.........VNIIIADLPYGNTVDWQTT........EDEP..LHQMLQNI...YETLDPDQSVVALISDKKQQTEHRY...YERVKALKHGKR..........................................................
R9KK57_9FIRM/2-90                   ................fsh-----------------.--------------------.------.-----.....----....-----------.---.--.--.-----.-..-...-.-----------..--.----------------------------..-----.--------------....--..---DVSAEIFEAD...CT...K.AL.PQVF..--.........PDIIITDVPYGNLVEWDSG........ELIA..IDLMLEQL...WT-ISHENTILAICMNKKQKINCSK...WKRLEKQSIGKR..........................................................
A0A4P6Q6L0_9ACTN/1-230              ...................MAYRYATERRDDSDLGG.GNVLYSAPGHPGFPVRLADE.LFQRAA.ARLGA.....--AP....FVLWDPCCGSG.QLA.VA.AA.MLHRD.R..L...S.RLLATDTDPAA..LS.VAERNVGLLSGAGLAERERELRAQAAEF..GKPAM.VERADAAARLAERL....RG..LGGDLDGAVRRGD...VF...H.PA.EPER..-P.........VDLVLTDIPYGDLTRFSGAp......pDADP..VPALVRAL...AAVL-PEHAVLAVTARTRKVALPAG...VGALERVRAGNR..........................................................
A0A4R6V306_9ACTN/1-230              ...................MGYRYATDREDHTDLAS.GQVLRSAPGYPGFPVRLGSE.LAQRAM.ARLPS.....--RP....LVLWDPCCGSG.YLA.TV.VG.LLHRD.R..L...A.RVLASDVDAEA..VR.LAGRNLRLLTAEGLAERAAEARGRAAGF..GKPSY.LAVAESADRLARGL....AE..RGGDLAHTVERAD...AF...A.PS.GPPV..P-.........VDLVLTDVPYGDLTHWSGAr......pDAEP..VPALLRAL...AAVL-PDHAVLAVTARTRRVPLPGG...VPALERARVGNR..........................................................
A0A1B1ZMM7_9PSEU/1-185              ...................MQYRHAPAAN---HAAL.DAALASAPGRPTLPVRLTVE.LFGRAR.EHVPG.....ARGT....LTVWDPCCGAG.GTL.AV.LG.LLCA-.G..V...H.RLAGSDADPRP..LD.LARRNLGLLGPGGLATRADELEELAARH..GKDAY.AGAAAAVRALVPRS....--..---RPEWSVGVAD...AG...-.-D.PAAV..RAalg...gavPDMVLADLPHDRQTTWSGL........----..--------...-------------------------...------------ppapgag...................................................
A0A6C0FVW6_9BACL/1-237              ...................MEYVYEQVRHNYEDFSS.GRVLLNAGGTTAFPVRLASE.LYLRAK.SYLPP.....ERGEq..pITIYDPCCGGA.YLL.TT.LG.LLHGQ.G..I...G.RLVGSDIDGKA..VE.LAKRNLAMANPEGIAERLAQLTALYAAF..GKTSH.KEAIESAERLQERI....AR..RNSRIETVCFQAD...AT...G.ER.ADYW..NAgg.....qaADIVMTDVPYGNVVTWSSE........DADP..LDSLLNHL...LGVV-RAGSVVVVVADKKQAIAHPA...YKRLEKLKIGKR..........................................................
D7AX50_NOCDD/1-231                  ...................MGYRYAVERTDHSALAG.GHVLRSAPGFPGFPVRLASE.LFQRAM.VHT--.....GGEP....VRLWDPCCGSG.YLA.TV.LG.LLHRD.L..L...T.GVRATDVDADA..VA.LAARNLRLLTAEGLAEREEELRRSARDF..GRVAF.VERAEAARDLAAGL....AA..QGGDLPHEAAVAD...VF...S.LE.EGVE..--.........ADLVVTDVPYGEMTRWEGNvp....ggAGEP..MRGLLASL...GRVL-PEHAVVVVTARTRRVSLPEG...VRALERVKVGNR..........................................................
A0A0N1NBN1_9ACTN/1-245              ...................MPYRHATERSDGSDFAS.GFVLHSAPNHPAFPVRLATE.LFLRAL.EHLPTp..tgPGSGp..gVTLWDPCCGSG.HLA.TV.LG.WCHRR.T..I...G.RVVASDVDGET..LS.LARKNLRLLSPEGLLDRERERLELSVRF..DKPAY.AEAARAAHRLAGRL....AE..DGGALPWSAGRAD...VF...D.PA.SLSA..LLasaglrgaaPDVVVMDVPYGERTHWGGQ.......aPERP..VPALLRSL...AAVL-PPHAVIAVADRARKIPVAP-...LRPLERLRIGTR..........................................................
A0A4R4M8E3_9ACTN/1-233              ...................MTYRFATERPDYSDLAS.GAVLRSAPGHPAFPVRLASE.MFLRAW.HALGR.....PR--....LTVWDPCCGSG.YLL.TV.LG.LLHRE.R..I...A.GIVASDVADGP..LR.LARANLGLLSADGLTDRAAELDELADRF..QRPAH.RTAAEAARRLRAQL....--..TPGDPPTVVGRAD...AL...D.PE.QVAA..LLaa....sgpPDLVLTDVPYGEQTTWQGT.......dPAAG..LPGLLDSL...AGAL-PAGTMVALATRGRRVPLPAG...TRTAARFRIGTR..........................................................
A0A0M4QLW8_9PSEU/1-190              ...................MQYRHAPAAN---HAAL.DAVLASAPGRPTLPVRLTVE.LAGRAR.AHLSA.....DAP-....LTVWDPCCGAG.VTL.TV.LG.LLEV-.G..I...T.RLVGTDADPEP..LD.LARRNLALLDPGGLTARAADLDALAARH..DKPSY.ADAATAARTLVPAStpawSV..AVADARDTAAVRG...VL...A.VA.SPDD..TG.........PDLVLADLPHGIRTTWAAS........PTRP..--------...-------------------------...------------gaad......................................................
A0A429B9G1_9ACTN/1-235              ...................MSYRHVLTKGDYSDLAS.GSVLRSAPGFPAFPVRLASE.IFLRAL.ALRGG.....DAP-....AVVWDPCCGSG.HLL.SV.VG.LLHRR.L..I...A.SLVASDISANA..LD.LAAANLLLLDPDALEARARVLEERAERF..DKPSY.LEAAGAARRLGGGL....AA..AGGSLPSLVRRAD...VF...D.RD.ELAA..VTaa.....ttPDIVITDVPYGEQTNWLGG.......hGEAG..VPEMLGNV...ASVL-PGEAVLAVTARGRKVPLGAG...PRPRKEFRIGTR..........................................................
A0A151YYY3_9BACL/1-230              ...................MKYHYEIEKKDYRDFAS.GRVLYNVPGSAPFPVRLASE.IFYRAQ.SFLNE.....EKNG....FKLYDPCCGSG.YLL.TV.LG.FLHAS.K..I...R.EIAASDDDEKM..VA.FARKNLSLLSFAGLRRREEEIRKYVKEY..GKPSH.IEALDSVQVLKAYL....--..KKEPIQITCFQRD...IT...K.PD.ENPV..QR.........VQVIITDLPYGNLVSWRGN........DENP..VQSLFENL...WKAMDLNNSVAVIITGQKIKPEHEG...FNRVHHFKVGKR..........................................................
L0EEW0_THECK/1-237                  ...................MEYRFATDEPR-GHFAS.GRVLYNAKGAAPFPVRLADE.IVQRCF.HYLEE.....RGHSg..pYAIYDPCCGSG.YLL.TV.IG.LLHGA.Q..I...R.AVFASDIDESM..LE.TARRNLSLLTAEGMRARIEQLRELYEQY..GKPSH.AEALESAAMLDGYR....-A..CGTVESIEMFPAD...IT...V.GS.PEAV..RDsg....fcpVNIVIADLPYGHLTGWQSG........SADP..AARMLDSL...FPLLRPGASVIALISDKSHKLRHER...YRRIALLKAGKR..........................................................
A0A2V2YVF5_9BACL/1-239              ...................MEYRYEAEPRSYEDYAS.GRVLLNAQGTTAFPVRLASE.IYQQGK.AYLAN.....KGRTs..gYTLYDPCCGGA.HLL.TS.IG.IRHGG.D..L...K.RVVGSDVDQRV..LD.IAARNLAMVNPDGMQTRIVQLQELVQAY..GKSSH.QEAVESAERLLALV....EQ..RNRTVDVQCCIYD...AI...G.QPsSSAV..LDel....ngqVDFVFTDVPYGDIVQWSAD........SADP..IGRLLGNL...MPRL-APVSVVAIVADKKQSVDHLA...FRRLKKLKVGKR..........................................................
A9KJB4_LACP7/1-224                  ...................MEYKY-TKNDNYEDFAS.GRVLYHVGGEPTFPVRLALE.IYERCL.QYSIK.....KAE-....ISLYDCCCGGA.YML.SI.LG.LLKSN.T..I...A.NLYGSDINSES..IQ.LANDNLGLLTKSGINKRRDELKALYQTY..KKASH.IDALHSIDRIEELL....--..-TREIKTYLFKGN...VL...E.VC.DLPF..T-.........PDIIITDVPYGNMVEWEEG........SG-G..INQMMNAL...SAVC-GSDTIICVCMDKKQKIHNDI...FQRLERQLVGKR..........................................................
A0A223SEA5_9ACTN/1-232              ...................MTYRYATERADRSDLAT.GHVLRSAPGHPGFPVRLADE.LFQRAA.SHLGS.....---D...pLRLWDPCCGSG.YLA.TV.LG.LLHRD.R..L...A.HILATDVDPDA..LG.IAARNLDLLTVDGLAARERELRAGAAEF..GKPSF.LERADAARRLADGL....AG..LGGDLPHTVRPGD...AF...V.PD.PPE-..HP.........VDLVVTDVPYGDLTHWSGDvp....apGTDP..LPALLHSL...ASVL-PDHAVLAVTARARKIPLPDG...VRALERVRVGNR..........................................................
V9GBS0_9BACL/1-237                  ...................MEYLYESVQRSYEDYAS.GRVLYNAHGTTSFPVRLASE.IAQRCF.HILEQ.....KGAGg..pYSLYDPCCGGA.YLL.TV.LG.LMHGQ.R..F...S.SVIGSDVNPEV..LA.IANKNLSLLTHQGLDHRIGQLQELFERY..HKPSH.QEALQSAARLKVLL....-D..RSRLEDASCYPAD...IT...D.SQ.SQAA..LNrp.....agIHMVITDLPYGDIVSWHGG........SGEP..VREFFEQI...HPMLDPGHSVVAVIADKGQKLRHDR...FKRLQQFKAGKR..........................................................
A0A1Y2MXF1_PSEAH/1-234              ...................MQYRHAGPA---NHAAL.DAVLVSAPGRPTLPVRLTVE.LLGRAR.SHLDG.....PGG-....-TVWDPCCGAG.VTL.TV.LG.LLA-P.G..I...T.ALVGTDVDPGP..LD.LARRNLGLLRTGGLSARAQELDALSARH..RKPAY.AEAAGCARSLVPAG....RP..AWSVGVADALDRD...RT...R.AM.L-GD..LE.........PDVVLADLPHGRQTTWATPtptttpgaDGDPpgTAAFLTAV...ASVL-DARAVLVAVDRGRTVPVPAG...VRPLERLRVGHR..........................................................
C4RPB1_MICS3/1-235                  ...................MTYRHETVRGAYGDLAS.GAVLRSAPGFPAFPVRLASE.VLQTAL.ELRPT.....SAP-....ATVWDPCCGSG.YLL.TV.LA.LLHRP.S..L...A.GLLASDVDEAA..LD.LARANLGLLTGAGLDTRARELAQRAEAF..DKPHY.AEAAAAAHRLRARL....DA..AGGPLPYAVRRAD...VF...D.RV.ALTE..AVag.....mtPDLVVTDLPYGEQTSWQGE.......rAGEG..LPGMLTRV...ASVL-PPTGVLAVVLRGRKVPPVGE...VRPRRRLRVGTR..........................................................
A0A1R3UKD8_9ACTN/1-228              ...................MSYRYATERTDHSALAS.GQVLRSAPGFPGFPVRLASE.LLQRAM.VHLGE.....DRA-....-RLWDPCCGSG.YLV.TV.LG.LLHRD.L..L...T.HVRASDVDADA..VA.IATRNLELLTAEGLAERERELRRSALDF..GRVTY.VERAEAARDLAAGL....AA..TGGDLPHESAVAD...VF...T.LT.EPVD..--.........ADLVVTDVPYGEMTRWEGE.......tPQDP..VPGLLSSM...GRVL-PERSVVVMTARTRRVQLPEG...VRALERVKVGNR..........................................................
G4L5U2_TETHN/1-235                  ...................MKFKFEPIKKDYSDFSS.DKLLVNAPRTPAFPVRVASE.IMARSL.SFLNS.....ADG-....LTLYDPCCGGG.HLL.TV.LG.FCYSK.N..L...K.NIYGSDIDTKA..LE.YAQKNLNLLTPEGLSKKKKDLQYNDEKQ..DEKTQ.LEALNSANRLEKQL...fHT..TYPKKDIQCFHWD...IT...R.KK.PPHL..KN.........VNIVITDLPYGKMSDWQGEg.....ttQNNP..NKQMLNNI...YQTLDLNNSIVTIICNKQEKINHQK...FEQVKRLKHGKR..........................................................
A0A326U6X4_9CHLR/12-244             ...................MTYRFTQEKQDYSDLAT.GRVLYSVPGRVAFPVRLASE.LFQRCL.SLYQQ.....RGGTt..pCVLYDPCCGGA.SLL.VS.VG.FLHGS.K..L...S.AVIGSDADPDV..LP.LAEKNLALLTPQGLEQRIAQLQTLYQEY..GKPSH.AEALESAYRLQRQL....--..--MPLTIGLFQAD...VM...R.PL.DPTRfpKS.........VDLVMVDLPYGQHTGWLHAs......aAQDP..ATALLDSL...RSIL-SPAAVVALITTKQHKVVHEQ...FRRLEQFSIGKR..........................................................
A0A1R1F2M5_9BACL/1-235              ...................MEYLYETKADSYEDYAS.GRVLYNAPGVTSFPVRLGSE.IVQRCF.GILED.....RGISg..pYTLYDPCCGGA.YLL.TI.TG.LLHGT.K..V...R.RMYASDVDPNA..LS.VAGKNLALLTKQGLTERELQLRELYGNY..GKPSH.KEALESLARLESAV....-S..GLTLDASVVFQDN...IT...E.PH.HLDH..VDq.......pIHLVLTDLPYGDLVSWESG........DADP..VSALFEHI...YPLLSSEGAVVAMIADKSQKLGHAR...YKRLQHFKVGKR..........................................................
D3EHE3_GEOS4/1-237                  ...................MEYIYESAQRSYEDFAS.GRVLYNAQGTTSFPVRLASE.IAQRCF.HILEE.....KGVQg..pYTLYDPCCGGA.YLL.TV.VG.LLHGR.R..I...R.RVIGSDINAEV..LG.IAGKNLSLLREEGLEQRTEQLKELLALY..HKPSH.QDALESADRLRELI....-R..MSRLEETFCFQAD...IT...Q.PQ.PEES..LAsc.....kgTQIVMTDLPYGDMVSWSGG........SQEP..VEDFFNGI...HAILDPVRSVVAVISDKGQKLKHDR...FKRIQHLKIGKR..........................................................
A0A1H3SVU9_9BACI/1-232              ...................MKFKYEVEKKDHRDFSS.GRVLINAPQTPAFPVRIASE.IMSRCL.SYINS.....NDC-....ISIYDPCCGGA.HLL.TV.IG.FLYRE.K..I...E.RVYGTEIDIKA..VG.YAKRNLNLLTSNGLFQRKKNILQNYNKF..GKVSH.LEALQSVKRLISTT....LD..SNHIKDIQCLDWD...IT...S.SK.PPVF..RN.........INIVITDLPYGNMAIWKGT.......kNMNP..IEQMLKNV...YYTLDLNNAVVSIICDKNQKVEHEW...FEQVKRLKHGKR..........................................................
A0A1H2ZGU3_9FIRM/1-225              ...................MEYRY-GKNINYEDFSS.GRVLYHISGMTNFPVRLAQE.IYGRCI.EYSRK.....KNN-....ICLYDCCCGGG.YLV.TV.LG.FLNQN.T..I...S.RIIGSDIDLEL..LE.VAKKNLSLLSEEGMDNRIKEIDNMIVNY..NKESH.AMAKESAIILRSMI....--..-KTPIQYEVFQAD...AL...K.EI.KLEI..-K.........PDIIITDVPYDQLVDWKGS........GEGL..VNRLLDVL...YGAC-TSDTIIGLSMNKKQKVKNDK...FIKLERQKIGKR..........................................................
A0A0C2G8J6_9ACTN/1-230              ...................MAYRYATERRDHSDLAS.GNVLRSAPGHPGFPVRLADE.LFQRAA.AHL--.....PAAP....VSLWDPCCGSG.HLA.TA.VG.LLHRA.R..L...C.RLLATDTDPAA..LS.IAERNLALLTLSGLAERESGLRDDAAAF..GKPAL.LERADTAARLAERL....RK..SGGDLDRTVRAGD...AF...D.PV.APEH..-R.........VDLVLTDVPYGGLTAFAGAv......pAGEP..VPALMRAL...AAVV-PAHAVLAVTARTRKVPLPEG...ARALERIRVGNR..........................................................
A0A419HR07_9PSEU/1-218              ...................MAYRFAVERENHEDLAS.GSVLRSAPGLPAFPVRLATE.VFQRAL.ALRG-.....LDR-....VVLADPLCGSG.YLL.TA.LG.LLHPE.R..I...A.AVLAADVEADA..VA.VARQNLALLSRDGLLARRAELVELAGRF..GKESH.RLAVAAADRLLTSL....--..-PADIPSTVEIRD...AF...-.--.TGLS..GD.........ADIVLTDLPYGEQVHWRGQ........SD--..VDALLDAV...FAS--APRAVVAVVARGRKVPARR-...-RARESLKVGTR..........................................................
A0A0H5SGT4_HERHM/1-224              ...................MEYKYA-MNCNYEDFAS.GRVLYNVSGVPNFPVRLINE.IYGRCL.GYSGK.....KEE-....ICLYDCCCGGG.YSL.TV.LG.FLNQG.S..I...A.RIIASDIDFMM..LE.IAKRNLSLLSEEGIKRRISELESLYKQY..NKESH.NEAIKSAKKLLNMI....--..-QKEIEVQVFQAN...AF...E.SI.ELDV..K-.........PDIIITDVPYGNLVDWQGG........TG-D..VSCLLESL...KNIC-SKETVIAVSMNKVQKINTKS...FIRLEKQNVGKR..........................................................
A0A6I4VWF2_9BACL/1-229              ...................MIYKYEMEKEDYSDFAS.GRVLHNAPNTTGFPARLGKE.IMSRCL.TQLRT.....DKN-....LILYDPCCGGA.HLL.TF.IG.FLYRE.H..F...A.EIYGSDIDEQV..LE.YAKRNLKLLTEEGLLARKEQLQRDFDIY..QKESH.LHALESVERLERLN....--..QTAVKQLQCFPFH...IA...G.IT.RPPI..QN.........VNIVFTDLPYGNIVDWKGS........KDNH..IQQMLTNI...YQILDLNNSIVAIVCDKKQKVIHGN...FEKIHAFHHGKR..........................................................
A0A124H0X9_9ACTN/1-235              .................ms-AYRHAVERIDSSDLAC.GVVLHSAPGYPAFPVRLATE.IFQRAV.ARLPG.....DGP-....VTLWDPCCGSG.YLL.TV.LG.LLHRR.S..L...R.QVIASDVDPAP..LE.LAAKNLALLSPAGLTARELERREQSERF..GKPSY.LEAAQAARRLRERL....TA..EGGALPCAIRTAD...VF...D.PR.ALS-..-Avia...gsaPDVVLTDLPYGERTHWEGQ.......vPGQP..VAGLLRSL...ASAL-PAHAVIAVTDRSRKIPVAP-...VRALERLKIGTR..........................................................
A0A5C8JSV3_9ACTN/1-235              ...................MTYRHAIARTSHEDLAS.GAVLHSAPGYPAFPVRLASE.IFQRAL.ALRGG.....DQP-....AVLWDPCCGSG.YLL.TV.LA.LLHRR.Q..I...A.AVLACDLDPEA..RN.LAERNLALLSQAGLAARAADLKARAARF..GKPAY.DSAARAACRLAAEL....DA..AGGDVPHAVRQAD...VF...D.PA.QLQ-..-Rtlg...qhaPDIVMTDVPYGEQTHWRGP.......sAAAG..VSGMVEAL...SAVL-PHGSVIAVTVRGRKVPMDRG...PRPQASFKIGTR..........................................................
D1BGB8_SANKS/1-223                  ...................MKFEHA-PQASYEDVGG.GQVLHSAPGFPGFPARLAVE.LFERAR.VLVGR.....E-R-....VGLWDPMCGAG.GIL.TS.VA.LLRPD.A..L...T.RVLASDVDEGA..LE.LARKNLLLTTVPGLEARRAELVE-----..-RGAA.AGRVASADRLLARV....-A..GLPAPPASLARAD...VT...D.PS.SVAG..LDl......dgVDVVMADLPYGTQTDWAST........STTP..TAQALEVL...RDAL-PDGAVVVLSTTEREHLRG-L...PDATRSFKHGHR..........................................................
A0A2N0JTU3_9ACTN/1-238              ...................MSYRHVTDRADYADFAG.GAVLRSAPGFPAFPVRLGSE.IFQRAT.ALRGD.....GRP-....AVVWDPCCGSG.YLL.TV.LG.LLHRR.S..I...G.AVLATDAAEPA..LG.LARRNLALLDPQALQERAAELDARAEEF..GKPSY.REAAESARRLGRTL....AE..YGGPLPVGVRRAN...AF...D.RE.ELAA..AVaaa...gyvPDLVLTDVPYGEQTDWLGAd.....adTDAG..VPEMLAAV...AAAL-PDHAVLAVTVRGRRVPLGG-...VRARESFKIGTR..........................................................
A0A4V2WPU6_9BACL/1-60               ...................MEYIYENQRDTYEDFAS.GRVLLNASGTTAFPVKLASE.IFLRGR.SYLRS.....RSEKk..kYSL--------.---.--.--.-----.-..-...-.-----------..--.----------------------------..-----.--------------....--..-------------...--...-.--.----..--.........-------------------........----..--------...-------------------------...------------fae.......................................................
A0A4Q2LP36_9BACL/1-236              ...................MEYKYETVSRSFEDFAS.GKVLFNARGTTSFPVRLGSE.IYLRAK.SYLRS.....TGNKd..rITLYDPCCGGA.HLL.TA.IG.ILHGH.D..M...K.RMIGSDIEPDV..VE.VAIRNLGLINLDGINARMEQLTQMVNEF..GKDSH.RQAVESARRLKEQI....VQ..RNTTLTATCFQAD...AT...A.EA.EYDD..RSl......gaVDMVITDLPYGNMVKWTSD........SANP..AEKLLENL...LPRL-SSDAVVAVIADKKQVIQNAN...YKRLQKFKIGKR..........................................................
A0A2T0ML69_9ACTN/1-234              ...................MPYRHAVVRANYEDLAS.GGVLHSAPGFPAFPVRLASE.MFQSAL.ALR--.....-GGG...pALVWDPCCGGG.YLL.TV.VA.LLHRR.L..V...S.GVVASDFNAEA..VH.LAERNLGLLTATGLAARAAELDERAARY..DKPAY.AAAALAAGRLAQGL....SA..EGGDVRGVARRAD...VF...D.PD.--AL..RDalg...glrPDVVLTDVPYGEQTSWLGP.......gAEGG..LGSMVRAL...GQVL-DEDAVIAVAVRGRKVPTDGG...PRPHATYKIGTR..........................................................
A0A1T5LV92_9CLOT/1-232              ...................MKYKFETNKRDYSDFSS.GRVLYYAANTTAFPVRLASE.VIQRSF.DILEK.....KGAHg..pFKIYDPCCGGG.FLL.TT.IG.FLYHD.L..I...S.ELIATDYDDKV..LE.IAKKNLSLLSKKGLDRRKEEIKGYIKAF..GKESH.MQALKSVDYLETLI....--..KKEAIKIVCMQRD...IA...D.LS.DFPI..KG.........VNIIITDIPYGIIVDWRGG........RKDP..IQNLFENS...YNALDKKRSVLVIIADKKSKLKHKS...FERTQYFKLGKR..........................................................
A0A560MQQ2_9MICO/1-225              ...................MRFDH-ANGERYEDAGG.GRVIHSAPGFPGFPPRLAVE.LFERAR.LLTG-.....RER-....VGLWDPMCGAG.GIP.TA.VA.MLRPE.R..L...Q.RVLASDVDPAA..VA.LAAKNLALATPTGLEERRRELAA-----..-RGAD.DDRLAAIDRLLDVP....-G..RSSAPRTDAVEAD...VT...D.AG.SLAR..LDl......dgIHVALCDLPYGTQTSWSASt......pARAP..AAAALDAL...DRVL-PAGAVVVLVTTERDDLRPL-...PNATRSFKHGHR..........................................................
A0A370I5T1_9NOCA/1-227              ...................MAYRFAVERTDYGDLAS.GAVLRSAPGLPAFPVRLASE.IFQRAV.ELRGG.....EQR-....AVVWDPLCGGG.YLL.TV.LA.MLHRE.R..I...A.GLIASDVDERA..LE.VARANLGLLTAAGLAARRGELADLADRY..GKAAH.LSALAAADRLTGSG....--..--GDLVASLGRAD...VF...D.TA.ALRA..LLap.....mpPDVVVTDIPYGEQVSWQGG........GK--..VEALLESL...DSVL-PADAIVAVTGRGR-RIESGR...FRPARSFRVGTR..........................................................
A0A091CDM9_9ENTE/1-233              ...................MKFKFETLKKDYSDFSS.DKVLVNAPRTPAFPVRIASE.IMARCL.SFLKS.....TDH-....LTIYDPCCGGA.HLL.TV.LG.FIYST.N..L...T.KIYGTDIDKSA..LT.YAQKNLNLLTDETLNQKIKTLQSVNKSQ..EEQTQsAEVLHSAKRLAALL...lDT..KAPQKEVQCFPWD...IT...-.EG.PPFF..KK.........VNIVITDLPYGNMAHWQGD.......iREQP..AKLLLDHI...YQTLDLNNSVVAIICNKNERIAHQN...FIQVNRLKHGKR..........................................................
A0A1I1FU39_9FIRM/1-155              ...................MNYLY-CPAGNYEDFAS.GRVIHGAKGIPNFPVRLIAE.IFGRAM.AVSPK.....KDH-....LVVYDPCCGGA.YSL.AI.IG.FFYGR.S..I...E.KIYGSDISEDM..IE.CARKNLEL--------------------..-----.--------------....--..-------------...--...-.--.----..--.........-------------------........----..--------...-------------------------...------------tlsidgkempvtwednasvnelkeilplkvnmsmyggfeqvgsigqsisrddkqitte
A0A4R1HGD8_9PSEU/1-225              ...................MRYHHAPAAD---HGAL.DAVLVSAPGRPTLPVRLTLE.LFGRAL.SFVGD.....GTGP....VTVWDPCCGAG.TTL.AV.LG.LCRGS.V..L...S.GLLGSDVDPSP..LD.LARRNLALLDPGGLDGRARDLDALAARH..GKASY.TGAASAVRGLGGAP....--..----VSHEVAVAD...AT...D.PA.ATAP..LVar.....hrPHVVIADLPHGIRTSWSGS........DD-A..ASELVTAL...AAVL-TPDAVIAMAGLGRKLVLPSG...TRALDRLRVGHR..........................................................
R9KC37_9FIRM/1-97                   ...................MEYFY-CPKDNFKDFAS.GQVLYGGGGIPNFPIRLLIE.LYCRAK.SYLPK.....SKD-....ITIYDPCCGGG.YAL.TV.LG.FFHNH.D..I...K.KMYGSDINPNM..VS.HAKKML----------------------..-----.--------------....--..-------------...--...-.--.----..--.........-------------------........----..--------...-------------------------...------------hy........................................................
A0A221W1A9_9PSEU/1-195              ...................MSYRFAVERTDHADLAG.GAVLRSAPGFPGFPVRLAVE.LFARAR.AWLPD.....RSE-....LTLWDPLCGSG.YLL.TV.LG.LLHRH.E..L...G.AVLASDVDPRA..CA.LAAENLGLLGEAGLRARSAHLRDLAERF..DKPSH.AEAAEAADRLTGLL....RA..GGGDLPAVVRRAD...AT...N.PT.ETRA..ATag....lppVDLVITDLPYGEQTAWQGQ........AG--..--------...-------------------------...------------aataaa....................................................
A0A1T4R189_9ACTN/1-230              ...................MAYRHVTERADFTDLAS.GQVLRSAPGFPGFPVRLASE.LLQRAL.AHLPQ.....RP--....VSLWDPCCGSG.YLA.TV.LG.LSHRD.R..L...S.HVRVGDVDSDA..VA.LAARNLELLTVEGLAARERELRAHAEEY..GRPSF.LERARAAARLADGL....VA..LGGDLPHAVEVAD...VF...A.PR.RPRP..-A.........VDVVVTDVPYGDLTHWAGDr......pAGEP..VTGLLRTL...AGVL-EDHAVLVVTARTRKIALPEG...VRPLERVRVGNR..........................................................
A0A553ZFN0_9ACTN/1-233              ...................MAYRYATERVDHSDLAS.GFVLRSAPGFTAFPVRLASE.TFQRAL.TLRGG.....DEP-....AVLWDPCCGKG.YLS.TV.VG.LVHRD.R..I...A.AVVASDIDDAS..LE.IARANLALLTARGLADRAAEQAGKAARF..GKPGY.TEAAAAAERLAARL....AA..DGGDLPHTVHHAD...VF...D.PS.ALER..AAag.....faPDIVVTDVPYGERVQWQGA........SDTG..LPGMLTSL...ARVL-PERGVIAIGIRGRKFPPVPG...VAS-RKFRVGTR..........................................................
A0A343JFC4_9CLOT/1-232              ...................MQYKFEISKKDFSDFSS.GRVLYNGLNTTAFPVRLTSE.IIQRAF.HILKA.....KGANg..pYKIYDPCCGGG.FIL.TT.IG.FLYNN.L..I...S.EIIATDYDIKV..LE.IAKKNLSLLSKEGLNKRSKEIQGYIEAF..GKDSH.LQALESIANLESLI....--..KKEDIKIKCMQRD...IT...D.MK.AFPI..EK.........VNIIITDIPYGNIVDWNTN........SENP..IQKLFENS...YKALDKNHSLMVVIADKKTKLEHKL...FKRIEYFKLGKR..........................................................
W2EII2_9ACTN/1-95                   ................lpa-----------------.--------------------.------.-----.....----....-----------.---.--.--.-----.-..-...-.-----------..--.----------------------------..-----.--------------....--..-------EARRAD...VF...D.AG.GLRE..VLgg.....rrPGVVVTDVPYGEQTSWLGP.......dGESG..AAGMLRTL...GAVL-PEGAVIAVAVRGRRPPRADGadgLVPRGSFKIGTR..........................................................
A0A317M415_9ACTN/1-229              ...................MSYRYATERVDHSALAS.GQVLRSAPGYPGFPVRMASE.LLQRAM.VHV--.....EGDR....VRLWDPCCGSG.YLV.AV.LG.LLHRD.Q..L...T.HVRATDVDEDA..VG.IAARNLELLTAEGLAERERELRRSARDF..GRVAF.VERAGSARDLAAGL....AA..MGGDLPHESGVAD...VF...T.MT.DPVG..--.........ADLVITDVPYGEMTHWDGSv......pDGDP..IRALLSSM...GRVL-PRSAVVVVTARTRRVPLPEG...VRALERVKVGNR..........................................................
A0A4P6JK52_9CHLR/1-245              ...................MPYHFARENQDFSDFAT.GRVFYSLPGHPAFPPRLASE.IFQRCL.ALRTR.....QEMSa..pCVVYDPCCGSA.SLL.SA.IG.YLHWS.V..I...R.HLIGSDIDAEA..LK.LAERNMALLTLEGLNQRCAELRTRAEQY..GRASY.EQAINSVQRLRQRL....QVmlKTHELSATLFHTD...AT...A.GS.ALCQ..KLgk.....qtVDIVLSDLPYGQQSSWRSAepa..pgeVLEP..VRQLLTAL...LPVL-ATHAIVALVTSKQQKVQHEA...YRRLSRFELGKR..........................................................
J7LF16_NOCAA/1-228                  ...................MSYRYATERADHSALAS.GQVLRSAPGYPGFPVRLADE.LLQRAM.VHV--.....EGDR....VRLWDPCCGSG.YLV.TV.LG.LLHRD.L..L...T.HVRASDVSSDA..VG.IAARNLELLTAEGLAERERELRRSARDF..GRVAF.VERAEAARDLAAGL....AA..MGGDLPHESAVAD...VF...S.LT.EPVD..--.........ADLVITDVPYGEMTHWDGE.......aPEDP..VRGLLASM...GRVL-PRNSVVVVTARTRRVRLPEG...VRALERVKVGNR..........................................................
#=GC seq_cons                       ...................MpY+atspctsapDhAS.GpVLhuAPGhPuFPVRLAoE.lapRuh.shlsp.....pss.....lslaDPCCGuG.aLL.TV.lG.LLHtc.p..l...s.plluSDlDsps..lp.lAt+NLuLLo.pGLttRtt-Lcthstpa..sKsua.t-AhpuAcRLtstl.....t..tssshstpshpAD...sh...s.st.t.sh.............sDlVlTDlPYGphspWpGs........ssss..ltthLpsl...hslL.sspuVlslssct+ph.hstt...hctlcph+lGpR..........................................................
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