#=GF ID   B2
#=GF AC   PF11473.12
#=GF DE   RNA binding protein B2
#=GF AU   Pollington J;0000-0002-8158-8998
#=GF SE   pdb_2az0
#=GF GA   25.00 25.00;
#=GF TC   26.40 25.80;
#=GF NC   24.10 19.50;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   16228003
#=GF RT   Dual modes of RNA-silencing suppression by Flock House virus
#=GF RT   protein B2. 
#=GF RA   Chao JA, Lee JH, Chapados BR, Debler EW, Schneemann A,
#=GF RA   Williamson JR; 
#=GF RL   Nat Struct Mol Biol. 2005;12:952-957.
#=GF DR   INTERPRO; IPR024377;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   B2 is expressed by the insect Flock House virus (FHV) as a
#=GF CC   counter-defense mechanism against antiviral RNA silencing during
#=GF CC   infection. In vitro, B2 binds to dsRNA as a dimer and inhibits
#=GF CC   the cleavage of it by Dicer. B2 blocks cleavage of the FHV
#=GF CC   genome by Dicer and also the incorporation of FHV small
#=GF CC   interfering RNAs into the RNA-induced silencing complex [1].
#=GF SQ   1
#=GS A0A1L3KFU8_9VIRU/2-77  AC A0A1L3KFU8.1
A0A1L3KFU8_9VIRU/2-77             akqafyeelrsmvqqlremgeryekvrdqlvppp------------------------------PSKVSKDLGNLAACIHKGRTAIIRGIETTLEKPTVREYL----ghs
#=GC seq_cons                     AKQAFYEELRSMVQQLREMGERYEKVRDQLVPPP..............................PSKVSKDLGNLAACIHKGRTAIIRGIETTLEKPTVREYL....GHS
//