GenomeNet

Database: Pfam
Entry: Coagulase
LinkDB: Coagulase
Original site: Coagulase 
#=GF ID   Coagulase
#=GF AC   PF08764.12
#=GF DE   Staphylococcus aureus coagulase
#=GF AU   Mistry J;0000-0003-2479-5322
#=GF SE   pdb_1nu9
#=GF GA   25.40 25.40;
#=GF TC   33.60 33.60;
#=GF NC   23.70 22.80;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   14523451
#=GF RT   Staphylocoagulase is a prototype for the mechanism of
#=GF RT   cofactor-induced zymogen activation. 
#=GF RA   Friedrich R, Panizzi P, Fuentes-Prior P, Richter K, Verhamme I,
#=GF RA   Anderson PJ, Kawabata S, Huber R, Bode W, Bock PE; 
#=GF RL   Nature. 2003;425:535-539.
#=GF DR   INTERPRO; IPR014874;
#=GF DR   SCOP; 1nu9; sf;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   Staphylococcus aureus secretes a cofactor called coagulase.
#=GF CC   Coagulase is an extracellular protein that forms a complex with
#=GF CC   human prothrombin, and activates it without the usual
#=GF CC   proteolytic cleavages.  The resulting complex directly initiates
#=GF CC   blood clotting.
#=GF SQ   4
#=GS G5KHP6_9STRE/32-326  AC G5KHP6.1
#=GS Q8E0A2_STRA5/37-300  AC Q8E0A2.1
#=GS Q2G1D3_STAA8/29-310  AC Q2G1D3.1
#=GS Q2G013_STAA8/2-227   AC Q2G013.1
G5KHP6_9STRE/32-326             rdnnkypkvsffe---------------NNDLIDSNYYKVAFEALDDKLFDINHWINSEEFKEKEFKNAIETLIVSTVQYEQYLNSLSKL-------SISNKDTEKPEYSHIDKLFIKKGINNLGIKNFNLIYESLKNNISNFNKEVKEIYKQHSDLYPFyyyvgsdvK........FN...EVRKEYyniyinqlNVIYNKLKIIDK.I.....IFDYSNSKKTK-DAVEILSFIskEITYQEKKS...P..YKnwysyIPNIRTANRKIQELDDAIDDFYSSVYIDRPKEYPRSMSFQNNE-...---------------------------------mkqidnikvdyilnperkqvsrevddfskiyrvngyt
Q8E0A2_STRA5/37-300             ....rqqlgyids-------------KKSGKKIDERWGEKIYNYLSYELIEANEWINRSEFQEPEYRTILSEFKDKIDSIEYYLINLSNIAKEDAH-------QR--NILQSLDKYEKSGIYNLDQGVYNYIYQEISSAKHKFSDGVDKIYRLDSTLFPF........SvwydkhldNNdnyKDNKDF........KEYIALLNEITRkArlgyqIVNNHKDGEHKDEAEILDILI.rDITFVSKDA...PgyKY.....IPNKRIAAKIIEDLDGIINDFFKNTGKDKPSLEKLKDTEFHK--...---------------------------------kylnstepysiet........................
Q2G1D3_STAA8/29-310             .............TKDYSGKSQVNAGSKNGTLIDSRYLNSALYYLEDYIIYAIGLTNKYEYGDNIYKEAKDRLLEKVLREDQYLLERKKSQYEDYKQWYANYKKENPRTDLKMANFHKYNLEELSMKEYNELQDALKRALDDFHREVKDIKDKNSDLKTF........N........AA...EEDKAT........KEVYDLVSEIDT.L.....VVSYYGDKDYGEHAKELRAKL..DLILGDTDN...P..HK.....ITNERIKKEMIDDLNSIIDDFFMETKQNRPKSITKYNPTTHNYKtnsDNKPNFDKLVEETKKAVKEADDSWKKKTVKKYG.....................................
Q2G013_STAA8/2-227              ....ddliwsfpn------------------------------------------LDNERFDNPEYKEAMKKYQQRFMAEDEAL-----------KKFFSEEK------KIKNGNTDNLDYLGLSHERYESVFNTLKKQSEEFLKEIEDIKKDNPELKDF........N........EE...EQLKCD........LELNKLENQILM.L.....GKTFYQ--NYRDDVESLYSKL..DLIMGYKDEeraN..KK.....AVNKRMLENKKEDLETIIDEFFSDIDKTRPNNIPVLEDEKQEEK...NHK-NMAQLKSDTEA--AKSDESKRSKRSK---rs...................................
#=GC seq_cons                   ....c..hh.h.p...............ssphIDppahp.hh.hLp..lh.h.thlNppEFp-sEYKpAhcchhp+hhp.-pYL.phpp......+..hup.cpc..phphp.spacKhsl.sLuhcpYN.lapsLKpshccFp+EVc-Ih+psS-LhsF........s........ts...EppKsh........pElhsLlspIsp.l.....lhsaapstca+--AcpLhuhl..DlhhspKDs...P..+K.....IsNcRhtpchI-DL-sIIDDFFpsstpsRPpphshhpspppp......................................h....................................
//
DBGET integrated database retrieval system