GenomeNet

Database: Pfam
Entry: ComX
LinkDB: ComX
Original site: ComX 
#=GF ID   ComX
#=GF AC   PF05952.12
#=GF DE   Bacillus competence pheromone ComX
#=GF AU   Moxon SJ;0000-0003-4644-1816
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   Pfam-B_4222 (release 9.0)
#=GF GA   25.00 25.00;
#=GF TC   26.00 26.30;
#=GF NC   23.90 21.30;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 45638612 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   12067344
#=GF RT   Specific activation of the Bacillus quorum-sensing systems by
#=GF RT   isoprenylated pheromone variants. 
#=GF RA   Ansaldi M, Marolt D, Stebe T, Mandic-Mulec I, Dubnau D; 
#=GF RL   Mol Microbiol 2002;44:1561-1573.
#=GF RN   [2]
#=GF RM   28391484
#=GF RT   Genomic and molecular characterization of a novel quorum sensing
#=GF RT   molecule in Bacillus licheniformis.
#=GF RA   Esmaeilishirazifard E, De Vizio D, Moschos SA, Keshavarz T;
#=GF RL   AMB Express. 2017;7:78.
#=GF DR   INTERPRO; IPR009233;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   Natural genetic competence in Bacillus subtilis is controlled by
#=GF CC   quorum-sensing (QS). The ComP- ComA two-component system detects
#=GF CC   the signalling molecule ComX, and this signal is transduced by a
#=GF CC   conserved phosphotransfer mechanism. ComX is synthesised as an
#=GF CC   inactive precursor and is then cleaved and modified by ComQ
#=GF CC   before export to the extracellular environment [1]. This family
#=GF CC   includes ComX phermones involved in quorum sensing. Amino acid
#=GF CC   sequence alignments between the two ComX precursor proteins in
#=GF CC   B. licheniformis, showed that their conservation is only
#=GF CC   restricted to the N-terminal ends. Moreover, high diversity in
#=GF CC   the amino acid sequence in C-terminus marked the
#=GF CC   pheromone-forming region, where, interestingly, the tryptophan
#=GF CC   residue is located [2].
#=GF SQ   54
#=GS A0A0M9DHB4_9BACI/1-51  AC A0A0M9DHB4.1
#=GS A0A0A2TJH9_9BACI/1-55  AC A0A0A2TJH9.1
#=GS A8FGX7_BACP2/2-53      AC A8FGX7.1
#=GS J7IZ32_DESMD/1-54      AC J7IZ32.1
#=GS K6CCG9_BACAZ/1-52      AC K6CCG9.1
#=GS A0A0M9DKK0_9BACI/1-50  AC A0A0M9DKK0.1
#=GS A0A0A5I474_9BACI/1-56  AC A0A0A5I474.1
#=GS A0A150KLH1_9BACI/1-52  AC A0A150KLH1.1
#=GS A0A0F6BRW2_GEOS0/1-50  AC A0A0F6BRW2.1
#=GS A0A0N0CWQ1_9BACI/1-51  AC A0A0N0CWQ1.1
#=GS A0A1T5FJK8_9BACI/1-51  AC A0A1T5FJK8.1
#=GS A0A268E1U6_9BACI/1-51  AC A0A268E1U6.1
#=GS A0A150F538_9BACI/2-56  AC A0A150F538.1
#=GS A0A0K9FIH0_9BACI/1-51  AC A0A0K9FIH0.1
#=GS A0A0M9DM16_9BACI/1-52  AC A0A0M9DM16.1
#=GS A0A0K9FA87_9BACI/1-52  AC A0A0K9FA87.1
#=GS R7ZAJ7_LYSSH/1-51      AC R7ZAJ7.1
#=GS X4ZTX5_9BACL/1-52      AC X4ZTX5.1
#=GS W4EW88_9BACL/1-47      AC W4EW88.1
#=GS C6CVJ9_PAESJ/1-56      AC C6CVJ9.1
#=GS X2GLJ8_9BACI/1-56      AC X2GLJ8.1
#=GS A0A0N0UW60_9BACI/1-51  AC A0A0N0UW60.1
#=GS H5Y5H0_9FIRM/1-55      AC H5Y5H0.1
#=GS A0A209DIG0_9BACL/1-58  AC A0A209DIG0.1
#=GS A0A089HIM6_PAEDU/1-56  AC A0A089HIM6.1
#=GS A0A150MPG0_9BACI/1-51  AC A0A150MPG0.1
#=GS A0A0J6EBA3_9BACI/1-52  AC A0A0J6EBA3.1
#=GS A0A1T5G7M7_9BACI/1-52  AC A0A1T5G7M7.1
#=GS A0A1H1U0J7_9BACL/1-55  AC A0A1H1U0J7.1
#=GS A0A0M8Q092_9BACI/1-50  AC A0A0M8Q092.1
#=GS A0A0W7YI98_9BACI/1-52  AC A0A0W7YI98.1
#=GS A0A1H8KC36_9BACI/1-50  AC A0A1H8KC36.1
#=GS A0A0H3E3B8_BACA1/3-54  AC A0A0H3E3B8.1
#=GS A0A0W7Y7I4_9BACI/1-51  AC A0A0W7Y7I4.1
#=GS Q65FH5_BACLD/1-53      AC Q65FH5.1
#=GS A0A1R1QEC2_9BACI/1-53  AC A0A1R1QEC2.1
#=GS W7YVC7_9BACL/1-52      AC W7YVC7.1
#=GS B7GGX4_ANOFW/1-51      AC B7GGX4.1
#=GS A0A1T2X7M0_9BACL/1-57  AC A0A1T2X7M0.1
#=GS A0A1M6B6N8_9FIRM/1-55  AC A0A1M6B6N8.1
#=GS A0A261QG36_9BACI/1-50  AC A0A261QG36.1
#=GS A0A1X9MJB9_9BACI/1-53  AC A0A1X9MJB9.1
#=GS X2GV45_9BACI/1-52      AC X2GV45.1
#=GS A0A0N0CUF0_9BACI/1-53  AC A0A0N0CUF0.1
#=GS F0T1C5_SYNGF/1-53      AC F0T1C5.1
#=GS A0A0B0HER4_9BACI/1-50  AC A0A0B0HER4.1
#=GS A0A160F6D7_9BACI/1-50  AC A0A160F6D7.1
#=GS R7ZDP7_LYSSH/1-46      AC R7ZDP7.1
#=GS E0I9Z4_9BACL/1-57      AC E0I9Z4.1
#=GS A0A0B0I344_9BACL/1-56  AC A0A0B0I344.1
#=GS A0A089LSE7_9BACL/1-56  AC A0A089LSE7.1
#=GS A0A0A5GD11_9BACI/1-56  AC A0A0A5GD11.1
#=GS A0A0A2UWP2_9BACI/1-55  AC A0A0A2UWP2.1
#=GS X2GT77_9BACI/1-51      AC X2GT77.1
A0A0M9DHB4_9BACI/1-51             ..m---NVIQYLEQNSSLVTLLKEQnKASLIGISSIEQQAILEAFNGELNTE...---SQIW..............
A0A0A2TJH9_9BACI/1-55             ...MLQKIVESLTNNPNLVEKLQEG.KLSLIGVSETEEAAIKDVFTTGSQDH...SKGMTYW..............
A8FGX7_BACP2/2-53                 ...KIQELVSYLVENPSTLNQIVNG.NASLLHVDQETASIIVDGFQKEDVIK...---AIIW..............
J7IZ32_DESMD/1-54                 ...MLQNVVEYLIENPDVKEKVKEG.SASLVGLTKMEQQAVIDSFEDEPSVV...-GPLQYW..............
K6CCG9_BACAZ/1-52                 ...MISEIIQHLVKNQEVLEQVQNG.FASLVGVSEEEVQIILDVLNGTVTTL...---SSFW..............
A0A0M9DKK0_9BACI/1-50             .mi---NMIQYLEQNPALVTLLKEK.KASLIGLTALEQKAILDSFNED----...-------lgvdnrl.......
A0A0A5I474_9BACI/1-56             ...MLQTVVEKLVESPDLLKQVREG.NASLAGISETEKAAILDVFDENSQEN..tVLGICYW..............
A0A150KLH1_9BACI/1-52             ...-MKEIIYNLIMNPEMKDQLKKG.NLCLLTNNENERKVVLATLVGDEVVN...--PLEYW..............
A0A0F6BRW2_GEOS0/1-50             ...-MQEIIRFLVEHPEVIEKLQNG.TVSLIGLSELEVKAVVKVFSESTE--...--PLGYW..............
A0A0N0CWQ1_9BACI/1-51             .mi---NMIQYLEQNPALVTLLKEK.KASLIGMTALEQKAILDSFDENVCS-...-------qdliw.........
A0A1T5FJK8_9BACI/1-51             .mi---NVIQYLENNPELVSLLKAQ.KVSLIGVSPIEQKAILDAFNSEVEL-...-------esgsw.........
A0A268E1U6_9BACI/1-51             ...-MQEVVNFLLENPEVIEKVMNG.QASLLGVELDDVLSVI----------...-------egilgagkllnmyw
A0A150F538_9BACI/2-56             .kk--QDIVNYLMENPRVIHQLEEG.EVCLIGIPHSLIPAIIDIFSNSTYKK...KPEFTFW..............
A0A0K9FIH0_9BACI/1-51             ..m--MNVIQYLEKNPDLVALLKTQ.KASLIGISSLEQKAILDAFNSEIE--...-------lksvaw........
A0A0M9DM16_9BACI/1-52             .mm---NTIQYLEQNPALVTLLKEK.KASLIGMTELEQRAILDSFDEEVKL-...-------efgvwy........
A0A0K9FA87_9BACI/1-52             .mi---NVIQYLEQNPSLITLLKEK.KASLVGVTELELNAIITSFDEEVRLE...--SSGFW..............
R7ZAJ7_LYSSH/1-51                 .mi---KVIQYLEPKSVLVTLLKDQ.KASLIGMSFIEKKAILDAFSGEI---...-------dlesdiw.......
X4ZTX5_9BACL/1-52                 ...MLKEIIQVLMKDPAAAHRLQNG.QFELAGVSEVEHRALLAALGD-----...-------rngfgkepq.....
W4EW88_9BACL/1-47                 .mm---KFIQYLQENPAFIQLLKDN.KLSLVGVTSLQQKAIVEAYD------...-------ndvclg........
C6CVJ9_PAESJ/1-56                 ...MLKDAIRSLAASKEKMSMVMGG.QLQLAGVSAAEHKALQDALKNQDEKK..gNYTLAVW..............
X2GLJ8_9BACI/1-56                 .ml---EIVQYIHKNRNILDLLKEK.RVSLLNVNELEQSLILESFEHGEKKTl.kDSYLMYW..............
A0A0N0UW60_9BACI/1-51             .mi---NMIQYLEQNPSLVTLLKEK.KASLIGMTELEQKAIVDSFNEDGGLE...---STIW..............
H5Y5H0_9FIRM/1-55                 ...MLQNVVEYLIQNPDVKERVQEG.TASLIGLTEMEQKAVHDVFESSGSTS...EIPIEYW..............
A0A209DIG0_9BACL/1-58             ...MLKEAIAMLSQNKEAWAALQTG.QLQMAGLGALEQKALRDVFNVNKEDRllkSDGLAYW..............
A0A089HIM6_PAEDU/1-56             ...MLKEIIQSLMKDPAAAHRLKNG.QYELVGISEVERRALLEALDDKNRVA...-------kagelgaw......
A0A150MPG0_9BACI/1-51             .me--KEIIRFLIEHPEVIEKLQNG.TVSLIGLSELEVKAVVRVFSESTE--...--PLGYW..............
A0A0J6EBA3_9BACI/1-52             ...-MQDIVSFLVQHPEVLEQVING.RASLLGVDDDQLISLIKAFNEFELNA...--KVTYW..............
A0A1T5G7M7_9BACI/1-52             .mi---NTIQYLEQNPSMVTLLKEK.KASLLGVTEIEQKAILDSFDEELC--...-------venrlwy.......
A0A1H1U0J7_9BACL/1-55             ...MLKEMIQAMVKDPGSLLRTQGG.QLQLAGLSDVEQRAFVDVVSKRESGS...-------esrllqi.......
A0A0M8Q092_9BACI/1-50             mik----AIQYLEQNPMLVELLREK.KVSLIGVNDLEVQAIVEAFDDE----...-------lrlenpl.......
A0A0W7YI98_9BACI/1-52             .mi---NVIQYLEQNPSLVTLLKEK.KASLIGISALEQKAILDSFDEDVRL-...-------englwy........
A0A1H8KC36_9BACI/1-50             ...-MKDIVYYLSTNLDVLELIKKG.KASLLGIGDSELSAILTATESGDLDT...----KYW..............
A0A0H3E3B8_BACA1/3-54             ..h-IDKIISHLANNPEAFDQFKNG.NLTLLNINEKEKKAILYAFEEGEV--...-------prtskw........
A0A0W7Y7I4_9BACI/1-51             .mi---NVIQYLEQNPSLVGLLKEQ.KASLIGVSPVEQKAILEAFSGEM---...-------iaesdvw.......
Q65FH5_BACLD/1-53                 ...-MQDIVNFLVENPEVLKKVVDG.DACLLGIDPEKTGVVVDSI-------...-------rllgkswggggfw.
A0A1R1QEC2_9BACI/1-53             ...-MQEIVSFLVQHPEVLEQVIAG.KASLIGIDQDQVLSLIDGFKKLEAFG...-KGPTYW..............
W7YVC7_9BACL/1-52                 ...MLKEIVQLLMKDLNQAEMFKNG.KLQFAGISPMEHRALQDVLNSKGNF-...-------qlvlw.........
B7GGX4_ANOFW/1-51                 ...MMQQIIRFLVEHPEVIEKLQNG.TVSLIGLSELEVKAVIKVFSESTS--...--PLGYW..............
A0A1T2X7M0_9BACL/1-57             ...MIKQMISYLTNNPQVTQLVRNG.QASLVGVTPVQQRTIVDTMSGGQ---...-------lpgtenvrktyw..
A0A1M6B6N8_9FIRM/1-55             ...MLQNVVEYLIQNPDVKERVQEG.TASLIGLTEMEQKAVLDVFESPDCTS...VSPLLYW..............
A0A261QG36_9BACI/1-50             .md---TTIHYLTNNPEVLEIVKQG.LASLVGVTKEEEQAIIQSFNEISIS-...---SYYW..............
A0A1X9MJB9_9BACI/1-53             ...-MQEIIQYIMENPDLIEKVKAG.TVQMVGLTIEENELLREVFQSNTIV-...-------daairka.......
X2GV45_9BACI/1-52                 ...-MKNIIHYLMKDTEVLHLLKNN.KICIIGISPEENKALIDVVLNKKPQL...--QAYYW..............
A0A0N0CUF0_9BACI/1-53             .mi---NMIQYLEKDPSLLTLLKEN.KASLIGVTELEQQAIITSFDQNETDL...--ENGFWf.............
F0T1C5_SYNGF/1-53                 ...MLQKVVEYLVQNPDEKEKLIEG.KLNLIGLTKVEQKAVLDVLQSPDVIS...--PLLYW..............
A0A0B0HER4_9BACI/1-50             ...-MQQIIRFLVEHPEAIEKLQNG.TVSLIGLSELEIKAVIKVFSESTR--...--PLGYW..............
A0A160F6D7_9BACI/1-50             ...-MQQIIRFLVEHPEVIKKLQNG.TVSLIGLSELEVKAVIKAFSESTR-S...---LGYW..............
R7ZDP7_LYSSH/1-46                 ...----MIQFLEQNPTLVTLLKEK.KASLVGVTALEQQAILESYEE-----...-------dlcldlr.......
E0I9Z4_9BACL/1-57                 ...MIKNVIAQLKQSPEMMSQFLQG.RLVPAGVSATEHQVMIEIMRAQKSPEd.kLNRGQYW..............
A0A0B0I344_9BACL/1-56             ...MLKEMIRKIVTEPEFMARIQNG.QLQLAGMSAFEQRAFLDVMQERKPDD..sLRKSAYW..............
A0A089LSE7_9BACL/1-56             ...MLKELIHSLMKDSAAAHRVKNG.QLEIAGISEIERRALTDALAA-----...-------drgvmkaeelgvw.
A0A0A5GD11_9BACI/1-56             ...MLQRIVETLTQNPGMVQKLQAG.ELNLVGISESEKTAILDVFQTEGQKE..rKQGMVYW..............
A0A0A2UWP2_9BACI/1-55             ...MLQTVVEKLVGNPDLLKQWKEG.AVRFEGLSQTEELALADVFDSQNTGE...IMKMSFW..............
X2GT77_9BACI/1-51                 .mi---NVIQYLEQNPALVSLLKEQ.KVALIGFSATEQQAILDSFEEE----...-------lclqqtiw......
#=GC seq_cons                     ....hpplIpaLhpNPpllphlppG.psSLlGlophEppAll-sFsppt...........................
//
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