GenomeNet

Database: Pfam
Entry: DUF2463
LinkDB: DUF2463
Original site: DUF2463 
#=GF ID   DUF2463
#=GF AC   PF09591.10
#=GF DE   Protein of unknown function (DUF2463)
#=GF PI   UPF0328; 
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF SE   Pfam-B_3132 (release 21.0)
#=GF GA   22.50 22.50;
#=GF TC   22.70 22.90;
#=GF NC   21.80 22.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 45638612 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF DR   INTERPRO; IPR019081;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This protein is found in eukaryotic, parasitic microsporidia.
#=GF CC   Its function is unknown.
#=GF SQ   35
#=GS Y6G5_ENCCU/155-368      AC Q8SV60.1
#=GS Y603_ENCCU/156-247      AC Q8STJ4.1
#=GS Y311_ENCCU/39-253       AC Q8SW76.1
#=GS Y8I5_ENCCU/36-245       AC Q8SU92.1
#=GS Y8K6_ENCCU/39-245       AC Q8SUI0.1
#=GS Y704_ENCCU/1-206        AC P0CS98.1
#=GS Y902_ENCCU/42-251       AC Q8STY8.1
#=GS Y3G2_ENCCU/41-242       AC Q8SVY8.1
#=GS Y9K3_ENCCU/37-246       AC P0CS99.1
#=GS Y706_ENCCU/38-245       AC Q8SV55.1
#=GS Y304_ENCCU/36-245       AC Q8SW83.1
#=GS Y5G4_ENCCU/31-239       AC Q8STF1.1
#=GS Y5G1_ENCCU/46-253       AC Q8ST42.1
#=GS Y107_ENCCU/37-231       AC Q8ST97.1
#=GS Y610_ENCCU/39-244       AC Q8SVF2.1
#=GS Y607_ENCCU/36-243       AC Q8SVF5.1
#=GS Y9K1_ENCCU/38-232       AC Q8STK1.1
#=GS Y602_ENCCU/36-249       AC Q8ST81.1
#=GS Y109_ENCCU/43-253       AC Q8ST67.1
#=GS A0A1X7UIR6_AMPQE/15-86  AC A0A1X7UIR6.1
#=GS Y808_ENCCU/43-253       AC Q8SUH8.1
#=GS YBL1_ENCCU/1-203        AC Q8STZ0.1
#=GS YAI7_ENCCU/221-424      AC P0CS97.1
#=GS Y202_ENCCU/40-249       AC Q8ST35.1
#=GS Y5G6_ENCCU/39-233       AC Q8STG4.1
#=GS Y505_ENCCU/36-249       AC Q8SVN9.1
#=GS Y503_ENCCU/231-434      AC P0CS96.1
#=GS Y302_ENCCU/43-246       AC Q8SW84.1
#=GS Y7I7_ENCCU/36-242       AC Q8STJ1.1
#=GS Y5G9_ENCCU/36-242       AC Q8ST65.1
#=GS Y410_ENCCU/43-253       AC Q8SVY6.1
#=GS Y313_ENCCU/35-245       AC Q8SW74.1
#=GS Y207_ENCCU/39-194       AC Q8SWH5.1
#=GS Y207_ENCCU/187-291      AC Q8SWH5.1
#=GS Y209_ENCCU/31-239       AC Q8SWH3.1
Y6G5_ENCCU/155-368                 .....FPAAMYFIFTKDSFEDSLFLRFITLLLPFSYSAVQYA-LLHTN...WKSHNKPEGILQSMLYYTLNLLLLAFTIISILSIIAFTLaewegDDWENNDDPIIFSFILPSFTVPLTYLLSVSCRLVPGHIGFTDTGINVLIDILILLCSTGNLVP..AFDEVK....HCYYFAIISSILILIRLLR.EKHGP..SEKSALPTAPWRVAILVLILIFAALIYLFMMWVSI........
Y603_ENCCU/156-247                 ....p-------------------------------------------...-----------------------------SIFSCPTLAG.....RKLESSGS-IFLSTTLPSFIVSIVYLLSVSCRLVPGQTAFTNTNSSVLIDIPILLCSVGSLSL..ILKEPK....YRSYLAIVSPT--------.-----..-----------------------------------ls......
Y311_ENCCU/39-253                  .....FPVVISFVLKETVDNNSPLSKLIIVLFPFLYSAVQHLLLFHGM...WASHHRPRGLLSKMPYYSLDFLFLTFGIISALSIIAFTV.....EKWQGDDDLLFHAITLPFLIISPTYLLSTSCNPTTGQIQFTDTAITALIDLIILSSYIIGITLtvLFRNRNvccpFPFIFAFASFILILLRSLK.ETFFP..SKQSSSSSL-WRKGIFVFIVISSIPGYLLTVCGPI........
Y8I5_ENCCU/36-245                  .....FPAIMYFIFTKDSFEDSLFLRFITLLLPFSYSAVQYAVLLHTN...WKSHNKPEGILHTTLYYTLNLLFLAFSIISILSITTLPI.....NKWKNDGGPILFSIFLPPLFMSPTYLLSTSCCLVPGQIGFTDTGINILIDILTLLCSVRSLLL..ILEESE....YCYCFAAISSILILIRLLR.EKHGP..SEKSALPTVPWRVSILVLILIFAALIYLFMMWVSI........
Y8K6_ENCCU/39-245                  .....YPIFMYLVFTKDCFEERHLLRLITLLLPFLYSTIQYLFLLYTN...WKNGHKQEDILYNILYYLLNLLLTTFSIISILSIIALII.....NRRENDDDLFFFSVILPS--MPLTYLLSTSCRLVPGQIGFIDTGINIFIDILILSC-LVSLTL..ICIEPK....DYLCFIAISSALTLVRLLK.KKYLS..SKQSPPPTAPWRVAIFVLIFSFVVFIYVLAACGSI........
Y704_ENCCU/1-206                   .....----MCLIFTKDRFEKSPFLKFIILLLPFSYSAVQYA-LLRTN...WKSDNKPEGILQSILYHTLSLLLLAFAAISILSITAFTL.....DKWESSES-IFFSIVLPSFFIPPTYLLSTSCRLVPGQIGFTDTGINVLIDIPILLCPLVSLVLiiALEETE....CCYYSAIISSVFILIRLLR.EKYSP..SEKSTLPTAPWRVAILVLILTLAALIYAFMMWGSM........
Y902_ENCCU/42-251                  .....FSMLMYLIFSKNDFNGTPFLRFVGVLFPSLYSSMEYFLLLFDS...WRSDHRVLLSLHGVLYLLLNTILFMFSFVTIISTIAFTA.....SKWNDNDDPATFTMAIPSFFVSFAYLLSISCDFSAKSVLSIGMSTNVPIDLLILLIPIIGTIL..LIEKSR....YHFYFFIVPAILIPVRSLK.ERYFV..SGKSSLSVAPWRTMVFVFMLILGVFVYAFLAYGS-v.......
Y3G2_ENCCU/41-242                  .....LPMLMYFTFTKNDFDTSPLLKVVMLLFPCSYSAAGYFLLCYSS...RTAHHKT-----GILYHLLNVLLVTFAAISILSIIVLPI.....EKWS-KRLLGVYSMPSSSFVVSLTYLLYTSCDLT--TASFTDTGITAFVELLSLLFLMSYPIF..LTRNPE....YYPYLSIISAILILARSFK.EKYFP..NKKTSESVVRWRLLIFFVILGFTTFSYIMAGLSCL........
Y9K3_ENCCU/37-246                  .....FPAIMCLIFTKDRFEKSPFLKFIILLLPFSYSAVQYA-LLRTN...WKSDNKPEGILQSILYHTLSLLLLAFAAISILSITAFTL.....DKWESSES-IFFSIVLPSFFIPPTYLLSTSCRLVPGQIGFTDTGINVLIDIPILLCPLVSLVLiiALEETE....CCYYSAIISSVFILIRLLR.EKYSP..SEKSTLPTAPWRVAILVLILTLAALIYAFMMWGSM........
Y706_ENCCU/38-245                  .....FSMATYLILDKDRFEKNPLLRFAIILLPLSCSAIQYLFLLYTN...WKSNYEPEGTLHKALYYFFNVLLIAFAIISILSIIVLPI.....NGWKGDDL--LSSIVLPSFFIPPTYLLSTSCCLVPGQIGFTDTGINVLIDILILLCPLVSLVL..IPEEPK....YRLIPAILFPVLILIRLLR.EKYYP..SGKSALPTAPWRVAVFVLILIIAVFAYALMVWGSM........
Y304_ENCCU/36-245                  .....FPAIMYFIFTKDSFEDSLFLRFITILLSFSYSAVQYAVLLHTN...WKSHNKPEGILHTTLYYTLNLLLLAFSIISILSITTLPI.....NKWKNDGGPILFSIFLPPLFMSPAYLLSTSCRLVPGQIGFTDTGINVLIDILTLLCSVGSLLL..ILEESE....YCYCFAIISSILILIRLLG.EKLSP..EKQSPPPTAPWRIAVFVLILIFAALIYAFMMWVSI........
Y5G4_ENCCU/31-239                  .....FPALIYLIFGKDRFEENPFLKFITLLLPLSYSAAHHLFLVHTS...WNRSNKPEGILHSISYYTLNLLLLTFATISILSIIAFPF.....DEWEGDDS-YYCSIILPSFFMPSVYLLSTSCCLVPGRIGFTDTGINVPIGMSILLCPAVSFVL..VCKESE....YHLLPAILFPILILIRLFK.EKCFP..SEKNALPTAPWRTAIFVFILILSIFIYTLMAR---vfv.....
Y5G1_ENCCU/46-253                  .....FPVFVFFTHREDGFDGNILLRFTTLVFPFSYSAAQHFLLLSSN...WGSSCRSSSGLYRALCLALNALLAVFFVISICSLILFTA.....DEWDDNEALTICSMLFPSLLLSSTCLLSISCNFA--TFQFVDSGPDIPIDLLIFLCLVILHKT.sPLEDYE....YLPYFAIPSFILVLVRSFK.ERLLP..-RKSSPPAAAWRVAVFLLILVLTISVYVFISRVCW........
Y107_ENCCU/37-231                  .....FPAIMYFISDEDSFKKSLLLRFITILLPFSYSAVQYAILLHTT...--------------PYYTLNLLFLAFAAISILSITALPI.....NEWKGDDS-LIFSIVLPSLFIPPTYLLSTSCRLVPGQTAFTDTGINVLIDILILLCPLVSLVL..VCKEPE....YRLLSAVPFPILILARLLN.DRYCP..SEKSAPPTAPWRVAILVLILTSAALIYAFMMWTPI........
Y610_ENCCU/39-244                  .....FPILMGLML-KETVKSSLFLRFIIMLLPFSYSALECFLLFRNN...LESSYRSE--LHKMPYSIFNVLLIAFSVISILSIAIFPL.....STWSNNDV-SSYSMLLPCLIVPLTYMLSISCSLVSGSILFTDTGIDILIDASLLLCTLLLLVF..WIIESK....YFPYFVFASLILVLIRSFR.TRHAP..SKENSLPVTAWRVVVFGSILVLSIVIYGSIAYE--ll......
Y607_ENCCU/36-243                  .....FPAAMYFIFDEDSFEGSLFLRFVTVLLPFSYSAVQYAVLLHTN...RMPHNKPEGILQSMLYYTLNLLLLAFTIISILSIIAFTL.....DEWENNDDSLLYSITLPSFFIPLTYLLSVSCRLVPGQIGFTDTGINVLIDILILLFPRTALVS..--KESK....HRLLYAVLFLLPILIRLLK.EKYCP..SGKSSLPTASWRVAVLALILILVFFAYTFMMCRSM........
Y9K1_ENCCU/38-232                  .....FSMATYLILDKDRFEKNPLLRFAIILLPLSCSAIQYLFLLYTN...WKSNYEPEGTLHKALYYFFNVLLIAFAIISILSIIVLPI.....NGWGNESDIAIYSVILPFFVVWSVDLVSTINDLTMETVHLIDTHYTMLFDLMMIITIIVNPKY..--SSQG....Y--------------R-YR.QSPTPssSRSTSSRTTKMRIVLLIIMLILAISMYAFIAWKCL........
Y602_ENCCU/36-249                  .....FPATMYFISDEDSFEDSLFLRFITVLLPFSYSAVQYA-LLHTN...WKSHNKPERILQSILYYTLNLLFLAFSIISILSIIAFTLaewedDDWENNNDPIIFSFILPSFTVPLTYLLSTSCCLVPGQIGFTDTGINVLVDILILLCSAGDLVP..AFDEVK....HCYYFAIISSILILIRLLR.EKLSP..EKQSPPPTAPWRIAVFVLILISIVIAYALLAY---lim.....
Y109_ENCCU/43-253                  .....LPVLMYYIPEKGQFDQNPFLKLIAILPPCLYSAVQFPLLFLGN...PESSCTPRPALYATLYLLLDASLLAFSAISILSIAAFTT.....TEWNSDEVVAVCSTLLPSLLVLPAHLLSTSCALTPGSIGFTDSSVDILIDLLMVSLLAAGLTL.nVDESWR....FFPYICISSLVLVLAKLLR.KSSSM..PRRDPAPAPAWRIAAFVLIFGLSMFVYFSILYECL........
A0A1X7UIR6_AMPQE/15-86             avaav-------------------------------------------...----------------LTVEMILALIANGVILSITLYQR.....KSWKQSSTIFFTSLILAHLVLNLLYLPFTIIALAAE---------------------------..------....-------------------.-----..-----------------------------------ehspdshy
Y808_ENCCU/43-253                  .....LPVLMYYIPEKGQFDQNPFLKLIAILPPCLYSAVQFPLLFLGN...PESSCTPRPALYATLYLLLDASLLAFSAISILSIAAFTT.....TEWNSDEVVAVCSTLLPSLLVLPAHLLSTSCALTPGSIGFTDSSVDILIDLLMVSLLAAGLTL.nVDESWR....FFPYICISSLVLVLAKLLR.KSSSM..PRRDPAPAPAWRIAAFVLIFGLSMFVYFSILHECL........
YBL1_ENCCU/1-203                   .....----MYFILTKDSFKDSPFLKFITVLLPYLHPPVLHLLLLHTN...WRKTHKSK---HTILYCLVNLLLLAFAVANILSIVALIV.....DKQKRTDDLLLHSIILPSFFIPPAYLLSTSCCLVPGQIGFTDTGINVIIDILILICPAISLVL..VDEKSK....YYPYSTAIPSILILVRLFR.EKCSP..PKQSSPPIPTWRVAAFVFILVLAVLVYGLLGSGSI........
YAI7_ENCCU/221-424                 .....FPAIMCLIFDEDSFEESPFLRFITLLLPFSYSAVQYA-LLYTN...WKSHNKPEPILHTTLYYTLSLLLLAFTIISILSIIPFSL.....NEWDHAAS-FFYPIVLPSFTVPPAYLLSSSYFLVPRQIRLTDTVISILISV----CSIVNVLL..VFKEFN....YYPYSAIISSISVLLQLLS.EKHCL..FKQSPPSTASSRAAVLILTLILAVLVYTFLGYGAI........
Y202_ENCCU/40-249                  .....FSALLYFIFDKDNFEKNPCLRLITTLFPLSYLAAQHLLLFHTS...WKGNNKPEDTLHKALRYFFSALFITFATIFILSIIILTN.....DNWSKDDDPLFFSIVLPSFFIPPTYLLSISCSLVPGQTGFTDTGINILIDVLILLCFIVNFIF..MHEKSK....YRLYSAVTFPLLVLVRLLT.EKYYP..SGKSSLPTTTWRVVAFVLIFILVIYTYTDMGCEAI........
Y5G6_ENCCU/39-233                  .....LPIAMYFIFDKDRFKEDPLLRFATILLPFSYSATQYLFLLYAN...WKSNYKPEDTLHKALYYSFNALLIAFATISILSIVALPI.....DGWGSRNDIVIHSVILPFFVVWSAYLTFTINCLIMKTIRLTDVNFCMLIALMMMIRIIVEFKS..--SNRE....Y--------------RYYR.QMPTP.mFRDTFLPTIKRMVSILTTMLVLATFMYAFIAWKCL........
Y505_ENCCU/36-249                  .....FPATMYFISDEDSFEDSLFLRFITVLLPFSYSAVQYA-LLHTN...WKSHNKPERILQSILYYTLNLLFLAFSIISILSIIAFTLaewedDDWENNNDPIIFSFILPSFTVPLTYLLSTSCCLVPGQIGFTDTGINVLVDILILLCSAGDLVP..AFDEVK....HCYYFAIISSILILIRLLR.EKLSP..EKQSPPPTAPWRIAVFVLILISIVIAYALLAY---lim.....
Y503_ENCCU/231-434                 .....FPAIMCLIFDEDSFEESPFLRFITLLLPFSYSAVQYA-LLYTN...WKSHNKPEPILHTTLYYTLSLLLLAFTIISILSIIPFSL.....NEWDHAAS-FFYPIVLPSFTVPPAYLLSSSYFLVPRQIRLTDTVISILISV----CSIVNVLL..VFKEFN....YYPYSAIISSISVLLQLLS.EKHCL..FKQSPPSTASSRAAVLILTLILAVLVYTFLGYGAI........
Y302_ENCCU/43-246                  .....FPAIMCLIFDEDSFEESPFLRFITLLLPFSYSAVQYA-LLYTN...WKSHNKPEPILHTTLYYTLSLLLLAFTIISILSIIPFSL.....NEWDHAAS-FFYPIVLPSFTVPPAYLLSSSYFLVPRQIRLTDTVISILISV----CSIVNVLL..VFKEFN....YYPYSAIISSISVLLQLLS.EKHCL..FKQSPPSTASSRAAVLILTLILAVLVYTFLGYGAI........
Y7I7_ENCCU/36-242                  .....FPAVMYFILTKDSFKDSPFLKFITVLLPYLHPPVLHLLLLHTN...WRKTHKSK---HTILYCLVNLLLLAFAVANILSIVALIV.....DKQKRTDDLLLHSIILPSFFIPPAYLLSTSCCLVPGQIGFTDTGINVIIDILILICPAISLVL..VDEKSK....YYPYSTAIPSILILVRLFR.EKCSP..PKQSSPPIPTWRVAAFVFILVLAVLVYGLLGSGSI........
Y5G9_ENCCU/36-242                  .....FPAAMYFIFTKDSFEDSLFLRFITVLLPFSYSAVQYAVLLHTN...RMPHNKPEGILQSMLYYTLNLLLLAFTIISILSIIAFTL.....AEWEDDDS-LLYSITLPSFFIPFTYLLSVSCRLVPGQIGFTDTGINVLIDILILLFPRTALVS..--KESK....DRLLYAVLFLLPILIRLLK.EKYCP..SGKSSLPTASWRVAVLALILILVFFAYTFMMCRSM........
Y410_ENCCU/43-253                  .....LPVLMYYIPEKGQFDQNPFLKLIAILPPCLYSAVRFPLLFLGN...PESSCTPRPALYATLYLLLDASLLAFSAISILSIAAFTT.....TEWNSDEVVAVCSTLLPSLLVLPAHLLSTSCALTPGSIGFTDSSVDILIDLLMVSLLAAGLTL.nVDESWR....FFPYICISSLVLVLAKLLR.KSSSM..PRRDPAPAPAWRIAAFVLIFGLSMFVYFSILYECL........
Y313_ENCCU/35-245                  ....s-SLFVYSISEENEIKSSLALRFIVTSSTFSYVIFSFSSCLHANlmlWKSDIKESSVTQKILYFLVNIISVVLIVASLLSIVGIPI.....NSWTYTKGPL--TALFPSLVL-FDYLASSLLNSALGAVSLTDS--NNHLDLVLLLLSSFLITSreWDNDFE....CSLYLSIASSIILLIMSLEdEDALP..STEEPSFVARTKVVIFTIVLLLVAIIHVFLGCISI........
Y207_ENCCU/39-194                  .....LPMLIHFIFEEDRFEENPFLRLITVLLPLSYSVIQYSALLHTN...WKESTKPEDTTHKALHYILNLLLLTFVVISIFSITVFTL.....DKWDYAAS-FFYSIVLPSLLIPPVYLFSTSCSFISGQIGFRDTGTDIFIDILILICDIVNVVL..VYKESE....FLSVF--------------.-----..-----------------------------------c.......
Y207_ENCCU/187-291                 ...se-------------------------------------------...---------------------------------------.....-------------------------FLSVFCGLIPGQTGFTGTGTNILINTLVSVFDIVNRVL..VYKESK....YYLYSAIILFVFILIRILT.EKHCP..SGKNSLLTAPWRIAVFVSILILAILVFTLIVHVSI........
Y209_ENCCU/31-239                  .....FTFFACYTFSEHDFKEDLFFRFIVLLPSFSYLILQYLIFFHTT...WKGYCKTESTLRNILHSTLIVLLLAFVIINIFSSITFVT.....DKWNSEDL-FFYSIILPSFFIPPTYLLSTSCDFI--TTSFTATGINILVDLMILLSYLTFLLLllFLEKAE....YRPYFILASFVLILVKSLK.EIYLP..SRESSSPAASWRVIIFALVFTLAVITHSLSAYVSI........
#=GC seq_cons                      .....FPhhMYhIhscDsF-cs.FLRFIslLLPaSYSAlQYhhLLaTN...W+SppKPEshLpshLYahLNlLLLAFulISILSIlsasl.....scWcsscs.hhaSllLPSFhlsssYLLSTSCsLVPGQIuFTDTGIslLIDlLlLlCslssllL..hhc-sc....ah.Y.ullSslLlLlRLL+.E+hsP..sccSs.PossWRlAlhlLILlLuhhlYshhsatsl........
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