GenomeNet

Database: Pfam
Entry: DUF5090
LinkDB: DUF5090
Original site: DUF5090 
#=GF ID   DUF5090
#=GF AC   PF17009.8
#=GF DE   Domain of unknown function (DUF5090)
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF SE   c_1844 - Hurt RP, Nakjang S
#=GF GA   27.00 27.00;
#=GF TC   49.10 48.80;
#=GF NC   22.80 22.30;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF RN   [1]
#=GF RM   24259309
#=GF RT   Reduction and expansion in microsporidian genome evolution: new
#=GF RT   insights from comparative genomics.
#=GF RA   Nakjang S, Williams TA, Heinz E, Watson AK, Foster PG, Sendra
#=GF RA   KM, Heaps SE, Hirt RP, Martin Embley T;
#=GF RL   Genome Biol Evol. 2013;5:2285-2303.
#=GF DR   INTERPRO; IPR031539;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This is a microsporidial-specific family of proteins of unknown
#=GF CC   function. The family is likely to be of four transmembrane
#=GF CC   domains.
#=GF SQ   24
#=GS A0A177ECV6_9MICR/1-184   AC A0A177ECV6.1
#=GS A0A1W0E424_9MICR/1-181   AC A0A1W0E424.1
#=GS L2GU68_VAVCU/1-195       AC L2GU68.1
#=GS L7JY28_TRAHO/1-195       AC L7JY28.1
#=GS A0A0F9WJ53_9MICR/1-181   AC A0A0F9WJ53.1
#=GS A0A4Q9LML0_9MICR/1-186   AC A0A4Q9LML0.1
#=GS A9CSE7_ENTBH/1-183       AC A9CSE7.1
#=GS A0A0R0LU48_9MICR/1-196   AC A0A0R0LU48.1
#=GS A0A437AIJ2_9MICR/1-183   AC A0A437AIJ2.1
#=GS R0KUF7_NOSB1/1-182       AC R0KUF7.1
#=GS A0A059F1B0_9MICR/16-201  AC A0A059F1B0.1
#=GS J9DCD6_EDHAE/1-194       AC J9DCD6.1
#=GS S7XLD2_SPRLO/1-186       AC S7XLD2.1
#=GS C4V6X8_NOSCE/1-181       AC C4V6X8.1
#=GS A0A4Q9M492_9MICR/1-186   AC A0A4Q9M492.1
#=GS T0LAE0_9MICR/1-182       AC T0LAE0.1
#=GS Q8SV27_ENCCU/1-180       AC Q8SV27.1
#=GS I3EJ40_NEMP3/1-186       AC I3EJ40.1
#=GS A0A1X0QDG4_9MICR/1-173   AC A0A1X0QDG4.1
#=GS A0A059EQL0_9MICR/16-201  AC A0A059EQL0.1
#=GS H8ZAE7_NEMS1/1-183       AC H8ZAE7.1
#=GS A0A1Y1S938_9MICR/3-179   AC A0A1Y1S938.1
#=GS L2GQ08_VITCO/1-199       AC L2GQ08.1
#=GS A0A0B2UJ12_9MICR/1-176   AC A0A0B2UJ12.1
A0A177ECV6_9MICR/1-184              .mavds-----......--KATKEAVS......KKVTETDQQAHEQIKK.LK....ESKVGKMLPTSFDKISTKHVAMVSMFTMYVMCGFVYTIC...VVATATKeg..evNPFFQSWSNYILLFW--........FAVSLVHDLVVY...FT...HNSSMLLSFILLRIIVVLSVG.FSLLALETHsaAVWFKLVLIVLFA----IFSTMYSYVFGVFMSDLKSGDAD--------psehqa.
A0A1W0E424_9MICR/1-181              ....ma--KNK......-DESQENVTQ......---KKVEDQMNNTKKV.IQ....NSAVARKLPKKVKNMGTKDLLKFSALIKFAYFFPTFIAC...DLVSNSKsenfiiKSLSTLATWICYITFVD........-----FANYFIY...FT...ELIDLFIVCYVATIIKTGIAM.LYIFAIFFA.lKGIVAKIAVLFFALSTLYVDTVFLLYLDIYFKEIRGEK----------ageqn..
L2GU68_VAVCU/1-195                  ......MAEPN......TEKVKEKAAEvkdtvkEKSDKAEQKVKESVKK.AE....KGKVGQHIPTSLDNLTFKDIIKCTLLLNAIMTIGLYVIV...SATRIN-......---IGSRWREILLTTAKfmi..lifGVGGIVIDAIFF...FG...RLFSLFKVFLGLKAVKLLGVL.IFCFAQKLG..-AWYIIVMSIVYLASCVLIDLCFVYYLAIFQERLESGEYDENGMPKTK.......
L7JY28_TRAHO/1-195                  ......MAEAN......TEKVKEKAAEvkdtvkEKSDKAEMKVKESVKK.AE....KGAVGQHIPTSLDNLTFKDIIKCTLFLNAIMTIGLYVIV...SATRVN-......---IDSKWREIFLTAAKymi..lifGVGGIVVDAIFF...YG...HLFSLFKVFLGLKAIKLLGVL.IFSFSQKLG..-AWYIIAMSFVYLCSCVFIDICFVYYLAIFQERLESGDYDENGMPKKK.......
A0A0F9WJ53_9MICR/1-181              ......MEEEN......---VQNQAIS......-QAAEVEKKVTEQITN.IE....NSKLASNLPTDVQSLHITDIIKLIFFTGIVNFFPLFLIF...GTEFSSK......FDFLRKILHLFFITF--........FVGSMLVTMCCF...IS...GAQEIYKFVVVVMFCKDVLGA.ILLLMFSTT..-SLTNLVFAFLYLAYILIQDLALLYYMGIYLKRLQSDKYDDYGVKI--vr.....
A0A4Q9LML0_9MICR/1-186              ......MSENK......TDKYKETAAA......-KAAEAEQKVHGTVEK.VE....KSSYGKKIPTSFEKVKFINIIKANAWINFIATIPIYIFIv.eDTNKASK......FKYVTKFLKYLFLFG--........GLIPVVLDVIAV...YL...KMPFLFKFIILSKTIKAVLII.LSMLVIAFG..-ALYVRLLAYFYMMMVILLDFLFVYYIALLFKRIDSEEYDNEGEKI--vr.....
A9CSE7_ENTBH/1-183                  ......MSETT......TNSKDTTNLLtqtqppANVNKV----------.IK....NSVIGKKLPMKVKNLKTEDLLKLTALVKFSFFVATVLLCeliTTYNGENp...ilKGFFKMSSWIAYVMFID........-----LGNYVIY...FL...ELIDLFNICYLATIIKTGITQ.LFFIAGFFI.lHGTLIKGFMIVYCCMSLYFDTIFLLYLDVHFKDIKNSS----------kreinhe
A0A0R0LU48_9MICR/1-196              ......MADSK......TERAKRKAAEvrdavaLQSAQAEKKTKETIKA.VE....KSKIGKHIPTSLDSATFKDVIKMTLFLNAIMTIGFYCIVn.sAATDVENa....iKRTALNICNYIILIF--........GLGGIVVDSIFF...FG...QLFALLKIFYLIKFVKFLGMV.LFLFATFRG..IGWFMMASEWLYTICCGLLDLFFMYYLTLYEERVASDDYDENGM----lkad...
A0A437AIJ2_9MICR/1-183              ...msd-----......---NKTEAVK......QKLEETDQKVKGTIKD.VE....NSKFGKSIPMEIRGLTLYDIIKFLTLFLLYSDLAIYLQI...QAKGSA-......----AGKITSTYSTVIKf.....vfYFAGVVGDIFVF...ASlllNIKTVFKFIVVIKVVKMVIVL.LIMFSISSI..-AIVSLLPAMIFGLLSCFFDIIHVYYTALFFERAESEDYDQYGTPIKK.......
R0KUF7_NOSB1/1-182                  ......MAAET......---GTQKMAD......-TANAAEEKAIQTIDN.VE....STKFGKKIPTNVHEVKLKDIFKIVLMSSTFNFIPCYLIY...GREYGNK......LDWLRAGLFLCFIIF--........SVTLFMFALVGY...AS...NTSAFFKFCLFSSIGKASFSL.ILMIMANIR..QGWIQFVLSLIFYLYLDVTDFLVLYYLAIFFKRIESDEYDDNGEPLKK.......
A0A059F1B0_9MICR/16-201             .shmsd-----......---KKTEEIK......QKLEETDQKVKGKLKE.VE....QSPIGKALPMEIRGLTLYHIIKYLGLFILYIDMAIYLQI...QAKDMAV.....nKGFFKKVSSKLFLIL-F........YIFGCVGDLFCFvtfLM...KLKDTFKFKLVFKCVKVVLTL.IIMFLIASK..--WYNIMTAMLFGGIACFLDLIFIYYVAMFYERLDSDDFDAYGSPLQ-k......
J9DCD6_EDHAE/1-194                  ......MSDTN......ATAEKAKVVKee..tvKKAKDADKAIDNQFNK.ID....QSKLGEFLPTHVENISLKTIVYFTIFLSALTTIAIYLMI...VAQNATK......---AKGEQKATFANLMCyll..livGICGIVYDMVVI...MM...RMMVFFKISLIIKLIKVINIF.CIGFCLEIS..-GIFTKGLLFIFLFGCFITDLLYIKYGYKYFSVNESNDGEQNTKEPE-p......
S7XLD2_SPRLO/1-186                  ......MAEQE......KVSAKDKALM......-KGKEAENKVKTKIFE.IE....NSAVGKRLPTQIENITLADVIWMTILSDAVLSLGIYLIV...------D......ALQMQKGFRATILMVDKyil..gfsTLLSFIIDGYCY...FM...RWGDGYLFFLILKCLKGVAML.VAMLASSFS..-GMITRILSIVYILSGIGLSLCLLYYMAIFLKRVESDEYDDFGQPVK-g......
C4V6X8_NOSCE/1-181                  ......MEEEN......---VQNQAIS......-QAAEVEKKVTEQITN.IE....NSKLASNLPTDVQSLHITDIIKLIFFTGIVNFFPLFLIF...GTEFSSK......FDFLRKILHLFFITF--........FVGSMLVTMCCF...IS...GAQEIYKFVVVVMFCKDVLGA.ILLLMFSTT..-SLTNLVFAFLYLAYILIQDLALLYYMGIYLKRLQSDKYDDYGVKI--vr.....
A0A4Q9M492_9MICR/1-186              ......MSENK......TDKYKETAAA......-KAAEAEQKVHGTVEK.VE....KSSYGKKIPTSFEKVKFINIIKANAWINFIATIPIYIFIv.eDTNKASK......FKYVTKFLKYLFLFG--........GLIPVVLDVIAV...YL...KMPFLFKFIILSKTIKAVLII.LSMLVIAFG..-ALYVRLLAYFYMMMVILLDFLFVYYIALLFKRIDSEEYDNEGEKI--vr.....
T0LAE0_9MICR/1-182                  mkadev-----......----GDKVQQ......-ETQEAEKKVQNTIKK.VQ....ESKLSRYLPTEIKEVKIKDIVKLLMLSIFSNFLPLYIIL...GGPWPKY......INFLRYIFFPLFIVL--........FSVQVFLGIITY...IT...CIEGLHIYLTIATVLKSALVL.VLLTIIEFK..FSFLQFFIIFTYLAWHTALDIAFLYYIAILLNNENSKTYDEHGVEIKK.......
Q8SV27_ENCCU/1-180                  ......MMEDK......----QEKVLG......-AVNAVEAKTMDTIDN.VE....KSSLGSSIPLEV-NLPLHEMTKYLMFFTMFESIPVYLIS...--CEGNKn...efLHWISRGTSLIFLIT--........AIVAGLLDLVTF...YG...KMSSLYKFVILTTGVRAIAAF.LVVVFSNIS..-SMYVVILAILYFLRIATFDGLFLYYFAILLRRIESDDYDNNGRRLK-a......
I3EJ40_NEMP3/1-186                  ......MNSSG......-ENSKTKAVA......EKVKQTDDKAHEQVQK.IK....ESKLGKAIPTEYKNIGIKQVALISLVLNSVVLVFTYALC...IALYPKKa...edSGFAKSISGICLGLT--........YAMSFCHDFFVY...WF...ERGTMLLSFVGLRVFSLLVTI.VVALFLTGPsaTILFKCFIILINIIFCL----MYMYIFAIYISHLKTGGSTEGGDQ---qev....
A0A1X0QDG4_9MICR/1-173              ....me-----......----------......---NKNEQANQSKVQNaIK....SNALAKKVPDKIESVNKTNILRSVALMKFFFFCGMASII...GAQKLSG......-GGASSGLFEGFRKVLNslkglfefILFVDMFNYLTM...FL...GLESLIYICVVATGVKLTLGFfLLILVFKGL..-FIFEKPFLIIFFVGVVTVDVMFIIYLDKSFEEDEIE-----------eenl...
A0A059EQL0_9MICR/16-201             .shmsd-----......---KKTEEIK......QKLEETDQKVKGKLKE.VE....QSPIGKALPMEIRGLTLYHIIKYLGLFILYIDMAIYLQI...QAKDMAV.....nKGFFKKISSKVFLIL-F........YIFGCVGDLFCFvtfLM...KLKDTFKFKLVFKCVKVLLTL.IIMFLIASK..--WYNIMTAMLFGGIACFLDLIFIYYVAMFYERLDSDDFDAYGSPLQ-k......
H8ZAE7_NEMS1/1-183                  ...mns---NTe....nNENSKTKAVA......EKMKATDDQAHMQVQK.IK....DSKLGKLLPTEYDRVSTKQVALISLILNAVVGVFTYALC...IALFSTNp....mASFAKSAWGIVLGIL--........YLLSFGHDLFVY...LT...DKGTMLLSFLGLRALSLLGTI.VVTLFLSGVsaTLMFKSFIILINILACV----AYMYIFSIYISHIKTG-----------gsvsgd.
A0A1Y1S938_9MICR/3-179              .gsqkk-----......----------......EEVKRAETAVDANVVK.ANealtNSAVARKLPKKVKNLGTEDLLKFAAVVKVCYFFPLFVACdlvATSRSDNw...fiKFFSKFATWICYVVFID........-----FVNYGIY...FL...ELYDMKGICYITTFIKQAISA.LFLLAMFFT.lSGLIAKVSIIFMACGSLYVDAVFLLYLDIYFKELTGDD----------mln....
L2GQ08_VITCO/1-199                  ......MVDQNpveptaDQNPAEAAANqnpmepDQVKKVDEKIEQNIEI.IK....ESRIGKAIPRELKNMRQKDLHFIALLIKTILLIPIFMFT...-------......--FDEGKSLVIGHTAIVyil..yvsILADIIVSFSIF...FK...FINLPAVVRIGVPGFKLLILL.IFSIILAIShdNNIFFYFLELIFYLLCIWIEFLHFFYSETKEEQLATEAETDTSKVAT-e......
A0A0B2UJ12_9MICR/1-176              ....me-----......--SSQDSVLK......-AVDAVEEKTNYAVDV.IG....NSSIGNYIPLEVKYLSLYEMTEYSMFFTILEIIPVYLMA...HADGKS-......--TFTHIMGTIFIII--........AMLSIGLSLAAF...YT...KMFELYKYVVIMSMTKVLIAS.IIVIFLNLS..-DWYIVILALIYALKIVGFEGLFLYYLAILFRRSQSDEYDDRGEKIK-i......
#=GC seq_cons                       ........ttp..........pppshp.......pspcsEpKscpplcp.lc....pSplG+plPsclcslshp-llKhshhhphhhhlslYlhh...ssptssp......htahpphhthhalhh..........hlhuhlhshhsa...ah...ch.shaphhllhphlKsllsh.lhhlhhphs...uhathhhthlahhhslhhDhhalYYhulahc+lcS--aDp.G..h.........
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