#=GF ID   DUF5708
#=GF AC   PF18969.4
#=GF DE   Family of unknown function (DUF5708)
#=GF AU   Hirsh L;0000-0002-8215-6716
#=GF SE   Jackhmmer
#=GF GA   26.90 26.90;
#=GF TC   27.30 27.50;
#=GF NC   26.70 26.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -E 1000 -Z 75585367 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF DR   INTERPRO; IPR043762;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family includes members in Actinobacteria.  All family
#=GF CC   members present double transmembrane.
#=GF SQ   80
#=GS A0A7Y6I7I1_9ACTN/1-60   AC A0A7Y6I7I1.1
#=GS A0A7K2X7Z2_9ACTN/1-60   AC A0A7K2X7Z2.1
#=GS A0A7M3LW30_9ACTN/1-61   AC A0A7M3LW30.1
#=GS A0A7K0C2C8_9ACTN/1-56   AC A0A7K0C2C8.1
#=GS A0A4R4PYA9_9ACTN/1-60   AC A0A4R4PYA9.1
#=GS A0A1D2IEJ9_9ACTN/1-60   AC A0A1D2IEJ9.1
#=GS A0A6G4WQ70_9ACTN/1-60   AC A0A6G4WQ70.1
#=GS A0A101JF29_9ACTN/1-60   AC A0A101JF29.1
#=GS A0A5Q0NS41_9ACTN/1-60   AC A0A5Q0NS41.1
#=GS A0A849AAN9_9ACTN/1-55   AC A0A849AAN9.1
#=GS A0A550HTX0_9ACTN/1-60   AC A0A550HTX0.1
#=GS Q9K4D1_STRCO/1-60       AC Q9K4D1.1
#=GS D5ZXC0_STRV1/1-60       AC D5ZXC0.1
#=GS A0A285IBB2_9ACTN/1-60   AC A0A285IBB2.1
#=GS A0A0M9X8X2_9ACTN/1-60   AC A0A0M9X8X2.1
#=GS A0A6G4U513_9ACTN/1-60   AC A0A6G4U513.1
#=GS A0A3B0BX74_9ACTN/1-62   AC A0A3B0BX74.1
#=GS A0A286E071_9ACTN/1-58   AC A0A286E071.1
#=GS A0A7W9LE52_9ACTN/1-60   AC A0A7W9LE52.1
#=GS A0A345XPT4_9ACTN/1-60   AC A0A345XPT4.1
#=GS A0A1H3S290_9PSEU/11-70  AC A0A1H3S290.1
#=GS A0A7W9Q4B8_9ACTN/1-60   AC A0A7W9Q4B8.1
#=GS A0A6B3ANX4_9ACTN/1-60   AC A0A6B3ANX4.1
#=GS A0A7W7LVP9_9ACTN/1-29   AC A0A7W7LVP9.1
#=GS A0A6I6RWD0_9ACTN/2-54   AC A0A6I6RWD0.1
#=GS A0A371Q9J5_STRIH/1-58   AC A0A371Q9J5.1
#=GS A0A8J8HI06_9ACTN/1-60   AC A0A8J8HI06.1
#=GS A0A1X4HXY2_9ACTN/1-60   AC A0A1X4HXY2.1
#=GS A0A1A5P722_9ACTN/1-60   AC A0A1A5P722.1
#=GS A0A7K3GUR8_9ACTN/1-61   AC A0A7K3GUR8.1
#=GS A0A3A4A366_9ACTN/1-60   AC A0A3A4A366.1
#=GS A0A8J3W8K5_9ACTN/1-60   AC A0A8J3W8K5.1
#=GS A0A263D1C1_9PSEU/1-59   AC A0A263D1C1.1
#=GS A0A4Z0GGK2_9ACTN/1-61   AC A0A4Z0GGK2.1
#=GS A0A1R1SIL4_9ACTN/1-64   AC A0A1R1SIL4.1
#=GS A0A2W2GAR0_9ACTN/1-62   AC A0A2W2GAR0.1
#=GS D7CCV9_STRBB/1-60       AC D7CCV9.1
#=GS A0A2G9DV26_9ACTN/1-60   AC A0A2G9DV26.1
#=GS A0A7K2YK75_9ACTN/1-60   AC A0A7K2YK75.1
#=GS A0A0A8ENH4_9ACTN/1-54   AC A0A0A8ENH4.1
#=GS A0A6N2HJD7_9ACTN/1-60   AC A0A6N2HJD7.1
#=GS A0A0L8L8C7_9ACTN/1-60   AC A0A0L8L8C7.1
#=GS A0A4R1DQ35_9ACTN/1-60   AC A0A4R1DQ35.1
#=GS A0A1Q8CLG6_9PSEU/3-56   AC A0A1Q8CLG6.1
#=GS A0A561WJK2_ACTTI/1-57   AC A0A561WJK2.1
#=GS A0A514JNW5_9ACTN/1-60   AC A0A514JNW5.1
#=GS A0A0P4R3J1_9ACTN/24-79  AC A0A0P4R3J1.1
#=GS A0A059VYX7_STRA9/1-56   AC A0A059VYX7.1
#=GS A0A089XF73_STRGA/1-60   AC A0A089XF73.1
#=GS A0A7W0CPT2_9ACTN/1-60   AC A0A7W0CPT2.1
#=GS S3AR93_9ACTN/10-69      AC S3AR93.1
#=GS A0A1D7VDY1_9ACTN/1-57   AC A0A1D7VDY1.1
#=GS A0A429B9Y6_9ACTN/1-60   AC A0A429B9Y6.1
#=GS A0A1M7R2V5_9ACTN/13-72  AC A0A1M7R2V5.1
#=GS C9Z8E1_STRSW/1-61       AC C9Z8E1.1
#=GS A0A7W5VPP5_9ACTN/1-60   AC A0A7W5VPP5.1
#=GS Q0RES9_FRAAA/1-57       AC Q0RES9.1
#=GS S4NLV2_9ACTN/1-60       AC S4NLV2.1
#=GS A0A2R4FQU1_9ACTN/1-60   AC A0A2R4FQU1.1
#=GS L7EWZ2_9ACTN/1-60       AC L7EWZ2.1
#=GS A0A3R7I5A6_9ACTN/1-60   AC A0A3R7I5A6.1
#=GS A0A7V8NFT7_9ACTN/15-73  AC A0A7V8NFT7.1
#=GS A0A7H8NIF2_9ACTN/14-71  AC A0A7H8NIF2.1
#=GS A0A0N0GWN6_9ACTN/1-54   AC A0A0N0GWN6.1
#=GS A0A1H5Z2N9_9ACTN/1-61   AC A0A1H5Z2N9.1
#=GS A0A7H8IRL0_9ACTN/1-59   AC A0A7H8IRL0.1
#=GS A0A2A2Z2X6_9ACTN/1-60   AC A0A2A2Z2X6.1
#=GS A0A1B1MHA0_STRLN/1-60   AC A0A1B1MHA0.1
#=GS M3D2E0_9ACTN/1-60       AC M3D2E0.1
#=GS A0A0X3UYH9_9ACTN/2-57   AC A0A0X3UYH9.1
#=GS A0A7W7CAG8_9PSEU/1-58   AC A0A7W7CAG8.1
#=GS A0A7Y5XCS5_9ACTN/1-56   AC A0A7Y5XCS5.1
#=GS A0A562VDM7_9ACTN/1-60   AC A0A562VDM7.1
#=GS A0A365GXM1_9ACTN/1-60   AC A0A365GXM1.1
#=GS A0A1T3NZK4_9ACTN/1-60   AC A0A1T3NZK4.1
#=GS A0A2Z5K7K5_9ACTN/1-60   AC A0A2Z5K7K5.1
#=GS A0A101J879_9ACTN/2-57   AC A0A101J879.1
#=GS A0A0K2AZ39_STRA7/4-61   AC A0A0K2AZ39.1
#=GS A0A438M7F5_9ACTN/1-60   AC A0A438M7F5.1
#=GS A0A7W8EKD8_9ACTN/1-60   AC A0A7W8EKD8.1
A0A7Y6I7I1_9ACTN/1-60              ......MTSARKTLLTGLATFVGGLALWLFGLDEEIVIFTPSKIGVVLMVVGGV.ETLYGVYKVV--sg............
A0A7K2X7Z2_9ACTN/1-60              ......MASPTKNFVEGAVLFAIGLPLRLFTGDVDVPVVTLTTVGNVLMVIGGM.EILYGAYRAA--cr............
A0A7M3LW30_9ACTN/1-61              ......MNTAVKNLVEGAGTLAVGAALWLVGGDVHVPVIDLDKTGVVVACVGAA.QLLYGGYL----tagra.........
A0A7K0C2C8_9ACTN/1-56              ...mre-------FIVGAVFTVAGLVLWLAARGVDTPVVSLHKVGLVVAVISGA.ETLWALWTMLR-r.............
A0A4R4PYA9_9ACTN/1-60              ..mapg----KVRLAEGGALVVGGGLLRLFGGDLELGWFDAHPLGVVLMVVGGV.QLLEGAWRLRR-g.............
A0A1D2IEJ9_9ACTN/1-60              ......MNRASRNLLAGAATLVAGLGLWLFDGGVDLPLVTPAKVGVVMMCVGGA.EVLLGLYRAART..............
A0A6G4WQ70_9ACTN/1-60              ......MSDAGKRAVEGTVLVLAGLPLWRFADGVDTPVITLSRAGLVLAVIGGV.TLLHSAWLAVRG..............
A0A101JF29_9ACTN/1-60              ......MSQASKNLLEGIVTFLIGLPLWLFTADVDVPVVTLTKVGLVMMCGGGA.LVLVGLYRRVR-e.............
A0A5Q0NS41_9ACTN/1-60              ......MSRHSRDLCIGAVMTLGGLVMFFAFHDVETPVIGLRQAGLVIAVLGLIeLVVTG-------wsilrs........
A0A849AAN9_9ACTN/1-55              ......MSKNSGHLVIGGVMLALGTVLALTTKNVETPIVSLDKVGIVLIVLGAI.------------evlwtlk.......
A0A550HTX0_9ACTN/1-60              ......MSPATKNLAEGSATLLAGLALKLFADGVEISFVSLGKAGVVMMVIGAV.QTLFGLFRTTR-t.............
Q9K4D1_STRCO/1-60                  ......MTRASKHLLEGAVTLLAGLALWLFTGDVEVPMVTLTKVGVVLMCVGGA.QTAWGLYGAAR-r.............
D5ZXC0_STRV1/1-60                  ......MSRASRNLLAGSVTLLVGLWLWRFARGVDLPLVTPAKVGVVMMCAGGA.EILLGLYRAART..............
A0A285IBB2_9ACTN/1-60              .mrspv-----KIMLAGAATFVVGLLSWLFTGDVETPVFNLQKVGVVLMVIGGL.EFLWGLYQAARA..............
A0A0M9X8X2_9ACTN/1-60              ......MTRASGNLLAGAATLVAGLGLWLFAGSVDLPAVDPVKVGVVMTCAGGA.EILLGLYRAARG..............
A0A6G4U513_9ACTN/1-60              ......MTPAKKNLMEGAITIVVGLCLWLFTDGVEIPVFTLTKVGLVLMVVGGA.VAATGLFQAMRG..............
A0A3B0BX74_9ACTN/1-62              ......MVPASKNIAEGAVCAVIGLALRLFTEDVHIPVFTLTKVGVVLMAVGGI.QLLYGVYQT---fsars.........
A0A286E071_9ACTN/1-58              ......MTKVARHATGGTVTALIGVLLWVFAGGVEVPVFELDKVGMVMVVVGIV.EVAVTL------vrgl..........
A0A7W9LE52_9ACTN/1-60              ......MAPARKTFLTGLAVFVIGLALWLFGLDVEIVVFTPSKIGVVMMVLGAI.EAAYGLYRMAR-d.............
A0A345XPT4_9ACTN/1-60              ......MNRPSRNLTEGSVTLLVGLALRLFTEGVETPVFTLTKVGAVLMVVGGV.LLLTGLVQAVRA..............
A0A1H3S290_9PSEU/11-70             ....ar--AARKTLVSGVVLALIGAVLWATTDGIELPVISPSKVGVVLLVVGAI.EIVVGL------amvigr........
A0A7W9Q4B8_9ACTN/1-60              ......MAAGVRHLIEGAAAVVVGLALWLFTGGVETPVITLKKVGVAVMCFGAV.QMMVGTWTTAR-q.............
A0A6B3ANX4_9ACTN/1-60              ......MKRAAEHCATGAGTVLGGLALWRYTQGVELPVVSLPKVGVLLMCLGAA.EILLGLYRAVR-r.............
A0A7W7LVP9_9ACTN/1-29              ..midp-----------------------------------ARAGVVMTCVGGA.EILLGLYRAART..............
A0A6I6RWD0_9ACTN/2-54              .kgiav----------GIFLAIVGVILWLTTKEVETPVISLHKAGLVLAIVGGA.------------ealfallglg....
A0A371Q9J5_STRIH/1-58              ..mkgi--------AVGIVLAIVGLILWLTTKEVDTGVVSLHKAGLVLAIVGGA.------------ealfallglgkkak
A0A8J8HI06_9ACTN/1-60              ......MDKSPKTLIIGSITFVIGLALWLWGLDEEIWLINPHKAGLVVMALGGI.EALYGVYKLTR-r.............
A0A1X4HXY2_9ACTN/1-60              ......MTRASRNLLAGPATLVAGLALWLFAGEADLPVVMPAKLGVVLVCVGGA.ETLLGLYRAVRG..............
A0A1A5P722_9ACTN/1-60              ......MNRASRNLLAGTATLAAGLGLWLFAGGVDLPLVTPAKAGVVMMCVGGA.EVLLGLYRAARA..............
A0A7K3GUR8_9ACTN/1-61              .msrlp----ERNVWEGGATLVVGLALLLFAGDVEVPVVELTKAGVVMMCVGGA.QTLWGMYRSAR-r.............
A0A3A4A366_9ACTN/1-60              ..maph----VKTLLAGLATLAAGTALWLFAPETQILGIAPAKVGVVLMVVGGL.ETLYGLYKAAR-r.............
A0A8J3W8K5_9ACTN/1-60              ......MTPARKTLLTGSATFLAGLALWLFGLDEEIFIFTPSKVGLVLMVVGGL.EILYGIYKSVRA..............
A0A263D1C1_9PSEU/1-59              ......MDADKRALFAGASMVAIGSALRLTTGEVPTPMVSLPKIGLVLLVL-GV.LEIAG-------tliwmaw.......
A0A4Z0GGK2_9ACTN/1-61              ......MNTTTKNLLEGGVTLVAGLALWLFGDRVDLPVISLVKIGVVASCLGVV.Q-----------lgyagylslgra..
A0A1R1SIL4_9ACTN/1-64              ......MTKALKQLLEGSVTLVVGLALWLFTGDVELPIMTLTKIGVVMMFWGGA.QLLYGAY-----lglagqrak.....
A0A2W2GAR0_9ACTN/1-62              ......MASPRKTLITGPAMIAVGAALWRFGLGFEIVVFTPSKIGIVLMAIGGV.ETLYGLYKM---ttavr.........
D7CCV9_STRBB/1-60                  ......MTKALKQLLEGSVTLVAGLALWLFTGDVELPVVTLTKVGVVMMCWGGA.QLLYGSY-----lgvag.........
A0A2G9DV26_9ACTN/1-60              ......MSPASKNLTEGTATFLVGLALKLFTGGVDIPVLTLPKVGVVLMAIGGC.LILLGLVQAGR-t.............
A0A7K2YK75_9ACTN/1-60              ......MTKTGRELLIGTATAVVGGALKLFADDVDTPVIALGKIGVVLVIVGVA.EVLYALYSMTRG..............
A0A0A8ENH4_9ACTN/1-54              ...mkg-------IVGGILLAIVGVILWLTTERMETPVISLHKAGLVLAIVGGA.------------ealfalmglg....
A0A6N2HJD7_9ACTN/1-60              ......MNPTMKALVGGGITFVIGLVLWQFTGDIETPVVTLTKLGVVLMALGVL.EVLYGLYKGV--ar............
A0A0L8L8C7_9ACTN/1-60              ......MSRASRNLLEGAATFGTGLPLWLFAGGVEVPVVTLTKVGVVLMCVGGA.LLVTGLYQAART..............
A0A4R1DQ35_9ACTN/1-60              ......MTRASKNLLEGVVTGVVGLALWLFTEDVEVPVVTLTKVGVVMMCVGGA.QVVMGLYQSVRA..............
A0A1Q8CLG6_9PSEU/3-56              ..epli----------GAVLLVVGLVLYLTTGDVHTPVVTLTKVGLVLMVVGGA.EIVVAL------arlvfg........
A0A561WJK2_ACTTI/1-57              .....m----TRNLLTGSATFVIGLLLWLFTGDIEIPVVTLTKAGVVLMVIGAA.EVGYGLYRAVRG..............
A0A514JNW5_9ACTN/1-60              ......MTGAARNLLAGAGTLVVGLGLWLFADGVDLPVVTPAKVGVVMMCVGGA.EVLLGLYRAVRA..............
A0A0P4R3J1_9ACTN/24-79             gkpmkg-------IAIGIVVTIAGLALWLSTEEVENSVISLHKAGMILAIIGAA.------------ealfallal.....
A0A059VYX7_STRA9/1-56              ..mkgi--------AVGVILAVVGVILWLTTKEVQTPVVSLHKVGLVLAFVGGA.EALFALFGAGR-k.............
A0A089XF73_STRGA/1-60              ......MNKASRNLSEGAVTLATGLVLWLFTGDVDTPVVTLAKAGVVLMCVGGV.LLATGLYQRVRG..............
A0A7W0CPT2_9ACTN/1-60              ......MDRSPKTLIIGLITFVVGLALWLWGLDEEIWLVNPHKAGLVVMALGGI.EALYGVFKLTR-r.............
S3AR93_9ACTN/10-69                 ....vr--RASKNLIEGSVTFLVGLALKLFAGDVETPVVTLTKAGVVLMCIGGI.QVASGLLRAKR-e.............
A0A1D7VDY1_9ACTN/1-57              ..mkgi--------AVGIVLAIVGLILWLTTKEVETPVVSLHKAGLVLAIVGGA.------------ealfallglgkka.
A0A429B9Y6_9ACTN/1-60              ......MASARKTLLTGSLTFVAGLALWLFGLDEEIFIVTPSKVGVVLMVLGGL.EILYGVLKTVR-d.............
A0A1M7R2V5_9ACTN/13-72             ..llte----KKALVSGLVTFVVGLVLWLFGSDNHVVLFTPSKVGIVLMVLGGL.EALWALFKAAR-r.............
C9Z8E1_STRSW/1-61                  ...msa--TAAGNLRDGAGTFVAGLVLWLFTDGVEVPVVTLTKVGVVMMCVGGV.LITTGLYQRVRG..............
A0A7W5VPP5_9ACTN/1-60              ......MAPAHKTLLTGLATFVGGVLLWQFGLDVEIVVFTPSKIGLVMMIIGGL.ETLYGVYKLMRS..............
Q0RES9_FRAAA/1-57                  ......MSNNVKSLITGAFMLAAGLILYFTTDGVKIPVFTLTKVGVVLVFLGAL.------------elvittgam.....
S4NLV2_9ACTN/1-60                  ......MTKARGNLVEGAVTLVIGLGLWLFTGDVEIPVFTLTKVGVVMMCVGGA.LVAAGLWQGAR-r.............
A0A2R4FQU1_9ACTN/1-60              ......MSSARKTLLTGLATFVVGLALRLFGPDEHVVIFTPTKLGVVLMVVGGL.ESLYGVYKIRR-d.............
L7EWZ2_9ACTN/1-60                  ......MSGATKNLLEGAATLVIGLVLWQFAGGVDIPFVTLTKVGVVLMCVGGA.LLLTGLFQRAR-p.............
A0A3R7I5A6_9ACTN/1-60              ......MASSMKNLIEGAITFVVGLALWLFTGDVEIPVFTLTKVGVVLMFVGGA.LLVVGLYQSV--tg............
A0A7V8NFT7_9ACTN/15-73             ....lp--KSTRNIAEGVLLLVVGLVLRQFLAGAEVPVIEPRVVGTVLIVMGVL.EVGWGLFQK---fg............
A0A7H8NIF2_9ACTN/14-71             ...pvv-----KHLVEGAATAVVGLALWLFTADVHTPVITLRKVGVVLMFVGAA.QLLYGAYV----gasa..........
A0A0N0GWN6_9ACTN/1-54              ..mkgi--------AAGVFLAIVGVILWLTTQQVETPFVSLHKVGLVLAVVGGA.------------ealfalvalg....
A0A1H5Z2N9_9ACTN/1-61              ......MASARKTLLTGLATFVAGAALWLFGGDIEIVVITPTKLGVVLMVIGGL.EALYGLYKV---ttra..........
A0A7H8IRL0_9ACTN/1-59              ......MAPAPKNFLEGALTLAGGTALWLLAGDIEIPFVNPVKTGMVVACLGVV.Q-----------llyagylgln....
A0A2A2Z2X6_9ACTN/1-60              ......MSAARKNLLEGVATFVAGLVLWLFTGGVEVPVFTLTKVGVVMMSVGGV.LVATGLYQAARS..............
A0A1B1MHA0_STRLN/1-60              ......MSKARGNLVEGAVTFLIGLPLWLFTENVEVPVVTLTKVGLVMMCVGGA.LGVTGLWQAARA..............
M3D2E0_9ACTN/1-60                  ......MNTRYGTVLTGALTALAGLLLWRFAGGVDLPVITPSKAGVVLMVLGAA.EA---LFGAV--ravgg.........
A0A0X3UYH9_9ACTN/2-57              .kgiav----------GIFLAIVGVILWLTTKEVETPVVSLHKAGLILAIVGGA.------------ealfallglgkka.
A0A7W7CAG8_9PSEU/1-58              ......MSKNVKSLFIGAFMLIVGLILAFTTKGIETPIISLDKVGVVLAILGGIeLVITG-------ammi..........
A0A7Y5XCS5_9ACTN/1-56              .....m-----RDLVGGVGLSGVGVLLKLYGGRVDLPAVSLDKLGVVLIVIGAL.EAAYGVFRMTRG..............
A0A562VDM7_9ACTN/1-60              .....m-GRMNRGVGEGVLLFLVGAGLWLFTGDVEIPVFTLSKVGVVLMVIGAV.TLVVGLVTAAR-r.............
A0A365GXM1_9ACTN/1-60              ......MAPARRTLLTGSITFVVGLALWLFGSDEQVFIFTPSKVGVVLMVIGGM.EALYGAYKSARG..............
A0A1T3NZK4_9ACTN/1-60              ......MAKARGSIVAGVVTALVGAGLKLFADDVHPPVFEPGKLGVVLLILGIA.EVLYGVYRSAQ-g.............
A0A2Z5K7K5_9ACTN/1-60              ......MSKARGNLVEGAVTFVIGLGLWLFTGDVEIPVFTLTKVGVVLMCVGGV.LAATGLWQGAR-r.............
A0A101J879_9ACTN/2-57              ...tak-------ILAGSATFVVGLLLWLFAGDVEIPVFTLTKVGVVLMVVGAL.EICYGLYS----gisr..........
A0A0K2AZ39_STRA7/4-61              ....ls----ERHLWEGGATFLVGLALWWFTGDVDVPVVTPTKVGVALMCFGGA.QTAWGVYRSAR-r.............
A0A438M7F5_9ACTN/1-60              ......MTSARKTLLTGLATFVGGLALWLFGLDEEIFIFTPSKIGLVLMVLGGV.ETLYGVYKTVRG..............
A0A7W8EKD8_9ACTN/1-60              ......MTSARKTLITGLVTFAAGLALWLWGLDVEIVIFTPSKVGVVLMVVGGL.EFLYGVFKAVR-p.............
#=GC seq_cons                      ......Mstst+sLlpGssThllGLsLWLFss-VElPVloLsKlGVVLMslGGs.phlhGlaphsR...............
//