GenomeNet

Database: Pfam
Entry: DUF6042
LinkDB: DUF6042
Original site: DUF6042 
#=GF ID   DUF6042
#=GF AC   PF19508.2
#=GF DE   Family of unknown function (DUF6042)
#=GF AU   Williams LS;0000-0001-5551-8526
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF AU   Fragoso S;0000-0001-7018-3891
#=GF SE   Manual
#=GF GA   26.80 26.80;
#=GF TC   26.80 27.30;
#=GF NC   26.00 26.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF RN   [1]
#=GF RM   16208464
#=GF RT   The lipopeptide antibiotic A54145 biosynthetic gene cluster from
#=GF RT   Streptomyces fradiae.
#=GF RA   Miao V, Brost R, Chapple J, She K, Gal MF, Baltz RH;
#=GF RL   J Ind Microbiol Biotechnol. 2006;33:129-140.
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This entry represents a member of a biosynthetic gene cluster
#=GF CC   (BGC). This BGC (BGC0000291) is described by MIBiG as an example
#=GF CC   of the following biosynthetic class, NRP (non-ribosomal
#=GF CC   peptide). This family includes a protein from the A54145
#=GF CC   biosynthetic gene cluster  from Streptomyces fradiae [1].
#=GF SQ   89
#=GS A0A0A8F2A4_9ACTN/103-360  AC A0A0A8F2A4.1
#=GS A0A562VCS5_9ACTN/11-251   AC A0A562VCS5.1
#=GS A0A6V8KXL2_9ACTN/10-250   AC A0A6V8KXL2.1
#=GS A0A4R7GZP8_9ACTN/1-198    AC A0A4R7GZP8.1
#=GS W7IXG0_9PSEU/14-268       AC W7IXG0.1
#=GS A0A1H6E082_9ACTN/12-122   AC A0A1H6E082.1
#=GS S4NVU3_9ACTN/1-119        AC S4NVU3.1
#=GS A0A495JT80_9ACTN/37-283   AC A0A495JT80.1
#=GS A0A3M8D2X6_9BACL/14-239   AC A0A3M8D2X6.1
#=GS A0A1M5S7A0_9FIRM/6-221    AC A0A1M5S7A0.1
#=GS A0A0N0A631_9ACTN/14-263   AC A0A0N0A631.1
#=GS A0A4R7PLH6_9ACTN/19-267   AC A0A4R7PLH6.1
#=GS A0A1X9MEI4_9BACI/20-171   AC A0A1X9MEI4.1
#=GS F2R329_STRVP/14-259       AC F2R329.1
#=GS A0A1I3NE84_9BACL/16-175   AC A0A1I3NE84.1
#=GS A0A4S8QB50_9ACTN/16-268   AC A0A4S8QB50.1
#=GS A0A6M1U9Z2_9BACL/14-239   AC A0A6M1U9Z2.1
#=GS A0A1J4PWM9_9ACTN/19-243   AC A0A1J4PWM9.1
#=GS A0A6M5J6J8_9MICO/7-266    AC A0A6M5J6J8.1
#=GS W7IXG8_9PSEU/14-251       AC W7IXG8.1
#=GS A0A1M4V5I5_9BACL/17-166   AC A0A1M4V5I5.1
#=GS A0A2U2ZBU3_9ACTN/24-160   AC A0A2U2ZBU3.1
#=GS A0A1A5XK34_9BACL/14-239   AC A0A1A5XK34.1
#=GS A0A1H6F4H6_9ACTN/195-382  AC A0A1H6F4H6.1
#=GS A0A6V8LBY0_9ACTN/14-274   AC A0A6V8LBY0.1
#=GS A0A0M8WJB8_9NOCA/35-275   AC A0A0M8WJB8.1
#=GS A0A075R9Z0_BRELA/15-241   AC A0A075R9Z0.1
#=GS F3NBV3_9ACTN/1-90         AC F3NBV3.1
#=GS A0A0M9ZZE3_9NOCA/23-264   AC A0A0M9ZZE3.1
#=GS D3QAJ3_STANL/9-248        AC D3QAJ3.1
#=GS A0A1Q5MPK8_9ACTN/15-269   AC A0A1Q5MPK8.1
#=GS A0A5J6FJ68_9ACTN/14-263   AC A0A5J6FJ68.1
#=GS V6MAL2_9BACL/14-239       AC V6MAL2.1
#=GS A0A0N9I0I6_9PSEU/175-340  AC A0A0N9I0I6.1
#=GS A0A5R9LS20_9ACTN/37-134   AC A0A5R9LS20.1
#=GS A0A2N3S5V9_9ACTN/4-248    AC A0A2N3S5V9.1
#=GS A0A1G9HCB7_9ACTN/19-267   AC A0A1G9HCB7.1
#=GS A0A5J6HGF9_STRAD/14-263   AC A0A5J6HGF9.1
#=GS A0A1I3UPL5_9BACL/14-239   AC A0A1I3UPL5.1
#=GS A0A364K6K3_9BACL/15-175   AC A0A364K6K3.1
#=GS A0A397LHK9_9MICO/1-90     AC A0A397LHK9.1
#=GS A0A1Z1W2Y1_9ACTN/8-257    AC A0A1Z1W2Y1.1
#=GS A0A1Q9LCB7_9PSEU/14-268   AC A0A1Q9LCB7.1
#=GS A0A543B3X6_9ACTN/8-251    AC A0A543B3X6.1
#=GS K0ATS6_GOTA9/7-198        AC K0ATS6.1
#=GS A0A2S4YVU0_9ACTN/16-248   AC A0A2S4YVU0.1
#=GS A0A5P0YP89_9ACTN/14-263   AC A0A5P0YP89.1
#=GS S4MZG9_9ACTN/29-79        AC S4MZG9.1
#=GS A0A0L0WE48_GOTPU/7-223    AC A0A0L0WE48.1
#=GS A0A1W2F9R9_KIBAR/166-380  AC A0A1W2F9R9.1
#=GS A0A1H8DHR0_9BACL/17-170   AC A0A1H8DHR0.1
#=GS A0A1M5SR25_9ACTN/14-263   AC A0A1M5SR25.1
#=GS A0A069RD05_PEPLI/7-222    AC A0A069RD05.1
#=GS A0A6V8K2X3_9ACTN/4-228    AC A0A6V8K2X3.1
#=GS C0Z774_BREBN/14-239       AC C0Z774.1
#=GS A0A5Q2N311_9FIRM/22-145   AC A0A5Q2N311.1
#=GS A0A317CY61_9ACTN/12-273   AC A0A317CY61.1
#=GS A0A4R6IWG0_9ACTN/232-360  AC A0A4R6IWG0.1
#=GS A0A0C2AY35_9ACTN/14-263   AC A0A0C2AY35.1
#=GS A0A1S1V5I0_9FIRM/3-215    AC A0A1S1V5I0.1
#=GS A0A4R3L6R2_9BACL/17-177   AC A0A4R3L6R2.1
#=GS A0A3G8ZJ74_9ACTN/41-289   AC A0A3G8ZJ74.1
#=GS G2GP32_9ACTN/77-193       AC G2GP32.1
#=GS G2GML9_9ACTN/1-133        AC G2GML9.1
#=GS A8MK06_ALKOO/5-220        AC A8MK06.1
#=GS A0A373D9N6_9MICO/9-262    AC A0A373D9N6.1
#=GS A0A2N0G283_9ACTN/17-249   AC A0A2N0G283.1
#=GS A0A6B2WTE8_9ACTN/37-134   AC A0A6B2WTE8.1
#=GS A0A1Q4VM42_9ACTN/16-272   AC A0A1Q4VM42.1
#=GS A0A561BPJ4_9ACTN/225-367  AC A0A561BPJ4.1
#=GS M8DFU4_9BACL/15-240       AC M8DFU4.1
#=GS A0A061M1A9_9MICO/2-255    AC A0A061M1A9.1
#=GS A0A5Q0H3T3_SACSY/178-345  AC A0A5Q0H3T3.1
#=GS A0A1C1A1E0_9BACL/22-157   AC A0A1C1A1E0.1
#=GS A0A1U9ZYC1_9ACTN/96-286   AC A0A1U9ZYC1.1
#=GS A0A4R7GZU5_9ACTN/14-64    AC A0A4R7GZU5.1
#=GS A0A6F8YS84_9ACTN/4-245    AC A0A6F8YS84.1
#=GS A0A6F8XK34_9ACTN/4-245    AC A0A6F8XK34.1
#=GS A0A1A5PB39_9ACTN/14-263   AC A0A1A5PB39.1
#=GS A0A2W2D186_9ACTN/93-226   AC A0A2W2D186.1
#=GS A0A1Q9LMS7_9PSEU/26-256   AC A0A1Q9LMS7.1
#=GS A0A0C2QC08_9BACL/33-168   AC A0A0C2QC08.1
#=GS A0A0U3NTS1_9ACTN/14-263   AC A0A0U3NTS1.1
#=GS A0A6I4VYU6_9BACL/16-169   AC A0A6I4VYU6.1
#=GS A0A3N2PEV3_9ACTN/1-208    AC A0A3N2PEV3.1
#=GS A0A5C4W4F7_9ACTN/171-356  AC A0A5C4W4F7.1
#=GS A0A1I2MNF9_9ACTN/189-406  AC A0A1I2MNF9.1
#=GS A0A1M5S5B3_9FIRM/7-222    AC A0A1M5S5B3.1
#=GS A0A1M6KEK4_9CLOT/7-222    AC A0A1M6KEK4.1
A0A0A8F2A4_9ACTN/103-360             ..................................................l-SLHNDWFPSGWMHVLPRH...HA.LLLT....MLFGTATVRQLRGNLDTLAvqvfgde....pgrgisafGDEG....LDSPL....lW.LEDDD.......................lEYAESPEDA.AQIR.AD.......AEEHQAWFEAALRAASLPVPSTVRELAAVMESFGIVQQSEG.....RWSVPY.HLPRPENVLALPDEILARLQSLRRHLTIEPAKQALLS.............Y.............LADSLGY..P.AAVSTSLDRLE.RATGCSVDELREALDYLAdeed...........ygtklLRGDPAIP.....VRARDLAVHARFQICMDWQQINENTIN-v.....................
A0A562VCS5_9ACTN/11-251              .................................................lm-----DWDHTGWCRFLPWE...GA.LLWR....MFCEATANDVT-GDLDTLV...................D---....-----.....W.YSEVDpva..................fgpEFFSGLDAR.IEHR.RS.......-WSDRRRLARLFDKATLVYPQTARQTAWAGRDLGLYRFDPDp...pRWRVPM.ALPLPTEVLPMTPRQRQVEDARRQHLLWSEPAAVIVE.............V.............LRDVGC-..P.ERVRTSVDELA.DLICEPPETVRHSLAFLNdtrfgghlgrpmmrvmtsfpQGADRTA-.....-DPERLEGPEEFQLVPNWQA--------laaty.................
A0A6V8KXL2_9ACTN/10-250              .................................................dw--QRAVMVPS-WIRWLPCS...FA.FLT-....---VVPDQERFRRSAWSML...................---P....WDKPV.....W.CDPGSvddwvv............qaqryhPRREADHAE.LHAR.DHydrvvrvRAARVELFTEMCLRRGLPVPHTLDELLACLVGFGLFEM-DG.....EWLLPR.LDQNPVDVLPLVGEEVVNEHRAQQDDRTVLVAITVRE.............L.............AEHSRPR.wRrRLVETDIGALA.GALRMPVEEIRRALTQLG....................-EIAGLV-.....VEPAPAVAQDRVRITVTWPAFARL----fpf...................
A0A4R7GZP8_9ACTN/1-198               .............................................miggdl-------------------...--.----....-------------------...................----....-DGVLt..fsW.AEEEW........................DYEEAPEGR.EANE.AH.......---RWETFGAILTAAGYPVPKTVRDLSELYLTWGLARREETpd.gtRWSMPA.ALPLPGDLLPLDADLAKRLDRIRWTLRTGPLVDGLIN.............H.............LVDDLGE..P.QEILTSLDRLA.AATSQDADDVRVALAELVqsg.............darvLRGQEPA-.....-DAERLEAHQRFRLVMNWDHFHEHRLQ-l.....................
W7IXG0_9PSEU/14-268                  ..................................................g-VFRDVFDGLGWSRFVPHA...AV.EVLGv..vVLLGAPTRDQI-GRLVGRT...................PDAVv..gLSGPA.....W.DEFEPwtehtlr.........taldgaapTPGEVARAN.AEDR.AW.......LDGLIAEIDSHADALGVFRPRTLSDVLDYLTACTVLIATGRdg.dtRYELNP.WAMLPAEVLPLTRDQVDEEDALRWIGLHRPVVRKLID.............L.............FGPYADA..PlDVLRTTLLELS.RTCGVDLESTRAAVTILA....................DQPDFEVT.....GDAERAEPGAELEIRVDWANFLEYRLD-i.....................
A0A1H6E082_9ACTN/12-122              ........................aateeqvaaayqpwssgsgpwdaalsv-------------------...--.----....-------------------...................----....-----.....-.-----........................---------.----.--.......------ELPEYAVKLGVPAPATRRELLRLLVAAGLVTTDGE....tRYRVVE.TPPRAEDVLRLPAGQSATIRGQDAHRRY---------.............-.............-------..-.-----------.------------------....................--------.....----------------------------apfaadlwtmgraa........
S4NVU3_9ACTN/1-119                   ...................................................-------------------...--.----....-------------------...................----....-----.....-.-----........................---------.----.--.......-----------------------------------------.....---MPA.ALPLPGDLLPLDADLAKRLDRVRWALRTGPLVDGLIN.............H.............LVDDLGE..P.QEILTSLDRLA.AATSQDADDVRSALAELVasg.............earvQRGPEPA-.....-DAERLEAHQRFRLVMDWDHFHENRVQ-l.....................
A0A495JT80_9ACTN/37-283              ..................................................r-WQRAALMPS-WIRWLPCS...FV.YLT-....--VVPQSVPFRRSAWNDLV...................P---....WDDAL.....W.CDPGDvedwvt............rsrhrhPRREAAHAE.LHAR.EHydwmvevRGARIELFAEMCRRRDLPVPHTVGELLPCLTGFGLFELDHDsdaddPWIRPR.LERDPLDVLPLSFEERELEARAQRDDRAVLLAIAVRQ.............L.............AQRTRRR.wRrRIVSTSVTGLA.EQAGLSVEQTRQALGDLG....................----EIAD.....LGLDWRDRDERVRLTVRWPDFRLRFP--ft....................
A0A3M8D2X6_9BACL/14-239              ..................................................t-VIPGGYRANGWSSVLPHE...MN.VLFH....ALCYLVAKYDSKEEMIQGF...................REI-....-----.....-.---NAl.....................ngTFDTLDKAK.FKSE.ESy....enYINLLETHKEFLKRSNYEYPQTKEEAIELMIKWGLVLDQGD.....VWDVPVhPFPEAQDIFVLNEREKFALDHLKLESLIHPIFSKLIL.............H.............LHEQDDN..HfSMTKAEMKKLL.DIEDTLLMEVLVKLIPYL....................----KAPI.....ENLQDLSDTDPMEFTVEWEKVYEDFLG-g.....................
A0A1M5S7A0_9FIRM/6-221               ..................................................i-NITKLMEEYMWFRYLPET...TY.KTY-....IMIGHLQNEDLRGEEASKK...................----....-----.....-.-----........................----LLTSH.FEIK.HE.......TGQLKEEKERVLQKIGHKYPTNRLEDLELLLSYRLIKVVKDedgnlVYLYNI.PIPKPEEVLNLDQEEKSILENIRFEFKHQDAFNSILT.............L.............ILNSNGN..-.--LMTTLDNIH.DVTKVKHSDIKEVLDYLVk..................eGSIKVKAD.....KDVKQLRKSDKIYINIDKDVFEKKRFI-i.....................
A0A0N0A631_9ACTN/14-263              ..................................................l-AMHNDWWASGWDHVLPR-...QG.FPLT....MLIGTASQPGFTGSLDELLqelf...........eghwDMIGg..dLDGVLt..fsW.ADEEW........................DYEEAPEGR.EANE.AH.......---RWEKFGAMLTAAGYPVPKTVRDLSELYLTWGLARREETpd.gtWWSMPA.ALPLPGDLLPLDADLAKRLDRIRWTLRTGPLVDGLIN.............H.............LVDDLGE..P.QEILTSLDRLA.AATSQDADDVRIALAELVqsg.............darvQRGQEPA-.....-DAERLEAHQRFRLVMNWDHFHEHRLQ-l.....................
A0A4R7PLH6_9ACTN/19-267              ..mhpawirimpcsielfrtvpsvnpfpatwwadafpeddiwnepvwcdpg-------------------...--.----....-------------------...................----....-----.....-.----Dvddwiaea.......tehhlgaspE---VIEKE.AREE.YDra..taeRSERIDTFTTHCRRAGLPVPHTVRDLLEFLLALGLYRSETRd..gkLLVAPL.LYINPFDVLAFDKVEALEEAADQRGDLEELTAIAIRRvggldfevddegrF.............ILPGNAK..S.ATVPVSLAALA.EDAGVPAPVIRGMLMELA....................EDGDVAGS.....VDLGTVPIQDEFNLT-------------asdd..................
A0A1X9MEI4_9BACI/20-171              .................................................vp--IPNGFMHNGWGAFLPPT...AI.VFLV...eVMNYAYEGLDAEGTIKAIEdyh.............yplA---....-----.....-.KKKNDqlffn.............fsqgvdDIRGKKKRE.LFL-.EE.......LESETE-RKKVLEQSGYYYPQTIRECIELGEKLGMIQRFKKeg.tdYYDVTInPFPHIK-------------------------------.............-.............-------..-.-----------.------------------....................--------.....----------------------------hylkgdeverwrs.........
F2R329_STRVP/14-259                  ...................................................MAMHNDWWESGWEHVLPR-...QG.FPLT....MLISTACQPGFTGSLDDLLqesf...........dghwNMIGg..dLDGALt..fsW.PDEEW........................DYEAAPEGR.EACE.AA.......---HWEQFSALLTTAGFPVPKSVRDLSELYLTWGLASREETpd.gtRWSMPA.ALPLPGELLSLDPELTARLDGMR----TGPLLDALID.............H.............LVGDLGE..P.AETLTSLDRLA.AATGQDVDDVRLALAELVssg.............darvQRGEEPA-.....-DAARLAAHRRFRLVMDWQHYHENRIQV......................
A0A1I3NE84_9BACL/16-175              ..................................................v-TLPPDFLQNGWNLFLPKG...TIsILLS....VMTYILQGYTK-EEILE--...................----....-----.....W.MKMEEkelsls...........pfdftlpFVCKSEEEK.QAY-.LN.......IARQERKICKILERSGYAYPKTIDEWIELLIQLKIVQEVKMde.aiYLDVVLePFPHPEDMLKLTPDERKKLEKYRLNQHMQQ-------.............-.............-------..-.-----------.------------------....................--------.....----------------------------lse...................
A0A4S8QB50_9ACTN/16-268              ........vqaqmhpawirimpcsielfrtvpslslfpaswwadvfpdddl-------------------...--.----....-------------------...................----....WNEPV.....W.CDPGDvddwite..........arehhfgTSAEVIEKE.AREE.YDra..taeRSERIATFTTHCERAGLPVPHTVRDLLEFLLALGLYRGETRd..gqLFVAPQ.LYINPFDVLAFGKLEAIEEAADQRGDLEELTAIAIRRvggveydfddeghF.............VLPGGGK..S.VEVELSLNELG.DDAGVPAQVVRGMLMELS....................EDGDVASS.....SNLATIALDEEFTLTA------------sdd...................
A0A6M1U9Z2_9BACL/14-239              ..................................................t-VIPTGFTANGWSSILSHE...MK.VLFQ....SMCYVVSQYDSKEEMTKALd................giK---....-----.....-.----Gl.....................kgTFAKPKKSM.FKSE.ADl....eaYKKLLEKHKAFLERSNYTYPASREEAIQLFEKWGLVLDKGE.....VWDVPIePFPDVQDLFVLSDAEKFALNHIKLETLVHPVFSRLVL.............A.............LHEKDDN..TfRMSKAEMKELL.KTNDAMLAEVLIKLTPYL....................----QEPI.....ENMLDIPDDQKMEFTVVWERIYEDFLG-d.....................
A0A1J4PWM9_9ACTN/19-243              ..................................................d-------------------...--.----....--FGTACQPGFTGSLDNLVhelf...........dghwDMIGg..dLDGALt..fsW.PDEEW........................DYEAAPEGR.EACE.AA.......---RWEQFSTMLTTAGFPVPTTVRDLSELYLTWGLARREETpd.gtRWSMPA.ALPLPGDLLPLDPELTERLDSIRWTMRTGPLLDTLSD.............H.............LVDDLGE..P.AETLTSLDRLA.AATGQDVDDVRLALAELVksg.............darvQRGEEPA-.....-DAERPEAHRRFRLVMDWEHFHENRIQV......................
A0A6M5J6J8_9MICO/7-266               .................................................vl--FQSVYLDSGWARILPNA...AI.EPAQi..aVRLQGATLEQFHAELAGSP...................HSAE...gLASDA.....W.EPLHQytddelaeldehfegtpfassdeeRQRTAAQVM.AHEA.QL.......RVAEVAEMDRFAAHLSVAPVRTFRDLIEFMTAAGVLRLNGG.....TYELNP.SALLPEEVLPLSDDVRHREESLRWQRLHEETEYAIIE.............L.............FRPHELA..PaDRIATTLSQLA.NELARPVESVREACAQLV....................AAPDFSTT.....HDMLVIGVDEPFTMSVDWEIFFATRIS-v.....................
W7IXG8_9PSEU/14-251                  .................................................av--SRQVFEGLGWERFTPHA...AA.GVLGv..iVLLGAPTREQI-ARLAGQS...................SDAAv..gEAAPA.....W.VGLEP.......................wDACGPDRER.AKV-.--.......LRDLVAEVDGYARGLGVVEPRTVGDVLDYLVACRVVTGFVEdr.raRFRLNP.RAPLPAEVLDLPAEVVAAEDELRWLALHRPVVRGLID.............L.............FGAHGDD..PvDVLHTSLGELA.GALRVEVESVRAAVVILG....................EQPDFEVG.....PDPERLRAGEPVRIAVDWANFLDFRFD-v.....................
A0A1M4V5I5_9BACL/17-166              .................................................iy--VPSGFLRNAWNLCLPKG...TL.SILL....SVMSYVLQGLSKEELLEQM...................R---....-----.....-.-REEKel....................hlSPFTFHLKN.DGAD.GE.......IIKRENEVRKLLERSGYEYPQNIESWLSLLVQVGILIEIRYkn.riFLDLVVePYPVPEKILTFQDDELHFLLIHRESLKTH--------.............-.............-------..-.-----------.------------------....................--------.....----------------------------k.....................
A0A2U2ZBU3_9ACTN/24-160              ..............................................rmarq------HMAGGWTRALSAA...GV.LIL-....GAVASRGRAVTRAELGGVL...................PVEP....VDGDRwaapcW.FD---........................----LDED-.----.--.......-AARVATLDRYAAAYKLGPVRTCADLLDLFAAAGVLWVDGD.....KIGPVA.PVPGVDEVFTVDDAERAEIARLRV-------------.............-.............-------..-.-----------.------------------....................--------.....----------------------------tsvr..................
A0A1A5XK34_9BACL/14-239              ..................................................v-VIPSGYTANGWYNVLSHD...MN.VLFQ....ALCYVVTKCESKEEMKKQL..................dG---....-----.....F.KGLQH........................VFSTPKKEK.FKSE.EDy....naYVAHVEKHKEFLERSGYQYPTSREEAIELLTKWGLVLDKGD.....VWDIPVyPFPDTMDLFQLTEAEQFALTHIKLEALVHPMFSRLVL.............K.............LHEHEEN..TfTYTKAELKEML.NTNDAMLTEVLIKLTPYM....................----EEPI.....DNLLEIPDDQPMTFTVVWERIYEDFLG-q.....................
A0A1H6F4H6_9ACTN/195-382             grtgweavlglpcqevlhavqvaaaagdateeqiaaayqpwssssgdwsgp-------------------...--.----....-------------------...................----....-----.....-.-----........................---------.----.--.......---LAEDLSDYAVQLGVPAPATRQELLRLLVAAGLVIAETSae.vtRYRPSA.SPPPVEEVLRLPDEQVTM---IRRQDAFHRYTSFAAD.............L.............AAVAMWS..PgCTVSATLEELS.HQLLATEEEIHGAIRY--....................--------.....----------------------------gteralfstsgdegmfta....
A0A6V8LBY0_9ACTN/14-274              ................................................vpv------LFQLGWFRWLPHAgfdFE.ELLH....RFPGTPREEVLAAQRVWNArrngadld...qnmepaalA--As..lPAAPA.....W.APPDP.......................pADGDPDEDF.AAEV.TH.......HANRVAAYNELLDRMGLRPVETAEQVLDLMVTIGLVHIDEHdd.qqPMRLTV.DPPLPTEALDMTPEERSAEDRMRWRSRHARLAQKVLR.............L.............FIDPASSdlArTTVPATLSRLA.NTTGAEPEDVRHAVQVLL....................DDGDFAAHrfgvpVDLERVHHRERFDLVVDPERFDRMHV--hl....................
A0A0M8WJB8_9NOCA/35-275              .................................................sy--MRTAWSNSAWPRLMPQE...AM.NLE-....VVIDTASVLSQDGDLAHLVtth............pasnQ--Fp.ngINTVL....tW.QDNDD........................DGETAMLRR.HAE-.--.......-----AAFTAAVTALARPVPTTVADLADLLADIGVFEHTHTengteQWRAPL.EIPDPMDALPLPADWIDREERIGWRTRTAGPAMALRR.............S.............LRAYEGR..-.PQVDTTLQRLA.GEADMPVSAVRAGLDGLMyrfg............vsvlRQGTTLDR.....RDLDALAEHARIGIVVDWTSFT------stt...................
A0A075R9Z0_BRELA/15-241              ..................................................i-IIPKGYDMHGWSTVFSHE...MN.VLFK....AVCYAVSKLETKEEMLKSIy.................sT---....-----.....-.RALEG........................TFDTLDKNK.FHDE.ENy....enYVALLEKYANFLKRSNYEYPATAQEALDMFIKWGLVIDKGT.....SLDVPVdPFPEVVDTFELRDDEMFALYHIRLESLIHPVFSQLVM.............Y.............LHEKEEN..EfSLSKNEIKEILgGINDNMLTEVLIKLTPYL....................----EEPI.....ERFQEIPDNEKMEFKVVWERIYEDFLG-t.....................
F3NBV3_9ACTN/1-90                    ...............................................mhhh-------------------...--.----....-------------------...................----....-----.....-.-----........................---------.----.--.......-----------------------------------------.....------.-----GDLLRLDADLAQRLDRMRWTMRTDPLVYGLIG.............H.............LVDDLGG..P.EEILTSLDRLA.DATGQDADDVRLALAKLV....................R-------.....----------------------------sargaghggsarhls.......
A0A0M9ZZE3_9NOCA/23-264              .................................................sc--TRADWTASGWHRLLPP-...IA.FSLE....MLIATATQDDADGDLDDLIaahsv.........laeqlP--D...rGATPL....rW.HE---........................----AGKES.VDLE.RR.......REQARETLSHALAGRGLPVPTTLRELADLLAQLGVYHHTRGtdgrhRWRALQ.--LPVVDLLDLPAEWLCAENDARWLMVTSMPAARLHR.............A.............LVHSERV..-.PTIPTSIDRLA.SDVDATAAEVRLGLEGLLyqgv............lsieRRGAALDS.....RQVREVPGHARIDLRMDWERI-------papdi.................
D3QAJ3_STANL/9-248                   ..................................................t--LRSDWDRTGWSRFLPFE...GE.VLWH....VFC-DATQWGIDGDIAVLF...................D---....-----.....W.QESMHp.....................vlSPGAGEREW.LPEP.RR.......RRPPRRVIARLLADSGEEYPTTVGEVAELGVSLGLYRRENDgt.tvRWRVPA.ALPLPTEVLPMTLRQRRVEDEYRWLLGGAEIARDLAE.............Y.............LVDCGEA..-.PESVTSVRHLA.DSLHCEPDSVRHGLEYLCaplagga......firvylgNGSRRRRQ.....VSPERLDVDDPCVIVPQWR---------klwkrfg...............
A0A1Q5MPK8_9ACTN/15-269              ..................................................l-ALHNGWFPSGWPNYLPQH...QA.MMLC....MVFGTAAVRGLRGSLDEVTqqlfng.......epgaffGRPGg..tLDSPV....vW.RDDDE.......................lEYLETDEDK.DQFR.TD.......AAEHQARCEGLLRAAGVAVPTTVRELADTMLALGIATVQDG.....VWSMQD.PIPGPETILDLTDAELARIADMRRVWESGPAESTLLN.............Y.............LTDVLGQ..P.DEVFTSVDRLA.QASKLREDDVRYVLGRMIqen.............earvERGTPRKQ.....VNLDDLKNHERFHLVADWQHFNENRIM-i.....................
A0A5J6FJ68_9ACTN/14-263              ...................................................MAIHNGWWPSGWEHVLPR-...QG.FPLT....MLIGTASQSGFTGSLDDLLqeif...........dgdwHMIGg..dLDGELt..fsW.PDGEW........................DYEDAPEGR.EASE.AK.......---RWKSFGAMLTAAGFPVPATVRDLSELYLAWGLAYREETpd.gtRWTMPA.VLPLPDDLLPLDAELTRRLDRARRTTYTGPLVNALIT.............H.............LVDDLGE..P.QEVLTSLDRLA.VATGRDADEIRLALADLVesg.............darvRRGQEPA-.....-DPERLEAHQRFRLAVEWEHFDGPR---thl...................
V6MAL2_9BACL/14-239                  ...................................................IVIPSGFKANGWADVLPHE...MN.VLFQ....AFCYVVTKYETKAEMEQAL...................GE--....-----.....L.KALEG........................TFATPTVDM.FKSE.QDf....egYVKLLNKHKAFFQRSNYEYPNSREEAIQLFSKWGLLLDKGD.....VWDIPVyPFPDVTGLFKLTEAEQLALSYVKLEALVHPMFSKLVM.............Q.............LHEQEEN..SfSYSKADLKAML.NTNDEMLAEVLIKLTPYL....................----EEPI.....DNMLDIPEDEKMSFTVVWERVYEDFLG-q.....................
A0A0N9I0I6_9PSEU/175-340             ...............yvvsvshddgatsdqitewavahhrpadwldeplad-------------------...--.----....-------------------...................----....-----.....-.-----........................---------.---E.--.......-----AWFTLFATQLGVTGQLTRRKLLDMLATVGVLTY-DG.....RYHTVR.PQPLAKDVLELPAELVSQLDSQSDHSQYGRFAADLVS.............V.............AGWLSGR..-.---PASLAWLA.ERALTTEQEVRRTLEFAV....................--------.....----------------------------tqqmldvsgesdltmtv.....
A0A5R9LS20_9ACTN/37-134              ..............................................isrsv-------------------...--.----....-------------------...................----....-----.....-.-----........................---------.----.--.......-----------------------------------------.....------.------------------ERQLRIDSVYEGDSYRSIE.............L.............FDPDGQR..R.SEVKTSLDRVA.RLIEGDTHGRREALRLLT....................ETGDFTTS.....RDLTGLPPYRVFAIRRDGEQFDQQRIA-i.....................
A0A2N3S5V9_9ACTN/4-248               ..................................................r-WQRAALTPS-WIRWLPCA...FV.YLT-....---VVPGEPRFRRSTWSTI...................P---....-----.....W.DGSAWcdpgsvde.......wvdrarrrrAGRDAEDAE.LHAR.QHyawmvriRATRIELFAEMCRRRDLPVPHTVGELLLCLAEFGLFEVSEGdg.ddPWVSPR.LDRDPLEVLPLSEAERELEARAQRDDQAVLVAIAIRR.............L.............AQRTRRR.wRrRLVSTSLTSLA.GVAGVTEEQARRSLVDLG....................----QIAE.....LGIDAGRGGDRLRLSVPWPDFRLRFP--ft....................
A0A1G9HCB7_9ACTN/19-267              .......mhpawirimpcsielfrtvpslnpfpagwwadafpeddiwnepv-------------------...--.----....-------------------...................----....-----.....W.CDPGDvddwiae..........asehhlgASAEVVEKE.AREE.YDra..taeRSERIDTFTTHCRRAGLPVPHTVRDLLEFLLELGLYRSEKRe..gvMYVAPQ.LYINPFDVLSFDKLEAIEEAADQRGDLEELTAIAIRR.............VggvdyefddegrfTLPGNAK..S.ATVQVTLAALA.DDAGVPAPVIRGMLMELA....................EDGDVAGS.....VDLGAVAVAEEFTLTA------------sdd...................
A0A5J6HGF9_STRAD/14-263              ...................................................MAMHNDWWVSGWEHVLPR-...QG.FPLT....MLIGTASQPGFTGSLDDLLqeif...........dgrwDMIGg..nLDGPLt..fsW.PDEEW........................DYEAAPEGR.EACE.AA.......---RWEQFSTMLTTAGFPVPNTVRDLSELYLTWGLARCEETpd.gtRWSMPA.VLPLPGDLLPLDPELTLRLDEIRWMMRTGPLLDTLID.............H.............LVDDLGE..P.AETLTSLDRLA.AATGQDVDDVRLALAELVksg.............darvQRAAEP--.....ADAERLEAHRRFRLVMDWEHFHDNRIQV......................
A0A1I3UPL5_9BACL/14-239              ..................................................v-VIPSSYTANGWSSVLSHE...MN.VLFQ....AFCYVTTKYETKAEMEAAL...................K---....----G.....F.KALEG........................TFTAPVKKQ.FKSE.EDy....ngYVNLLNRFKAFLSRSNYEYPTSLEEAVALFEKWGLIIDKGD.....VWDVPVyPFPDAADLFQLNEAETLALAHVKLEALVHPIFSRLIM.............M.............LHERDEN..SfTLSKAELKSML.NTNDEMLAEVLIKLTPYM....................----EKAV.....EGILEIPEDESMTFTVVWERVYEDFLG-e.....................
A0A364K6K3_9BACL/15-175              ..................................................i-TLPASFLQNGWNLFLPKG...TIsIMLS....VMTYILQGYSKAEILELMI...................----....-----.....-.MEEEElsltpf............nftvpfTYKTEE--E.KQVY.LT.......ISRQEKRIYKVLERSGYTYPKTIQEWVELLIELKIIQEVIRee.kiFLDIVIePFPHPKEVLTLTTDELKKLDKYQINQHIES-------.............-.............-------..-.-----------.------------------....................--------.....----------------------------lsev..................
A0A397LHK9_9MICO/1-90                ...................................................-------------------...--.----....-------------------...................----....-----.....-.-----........................---------.----.--.......-----------------------------------------.....------.---------------------MRWGHLHETAAQEIIR.............L.............FRPDGET..I.DHLLTDLGQLA.ERLDRDPEDVRSALQTLI....................DSGDFSAT.....VNLETVTVGESFVLRVDWAAFNASRIA-i.....................
A0A1Z1W2Y1_9ACTN/8-257               ...................................................MAMHNDWWATGWEHVLPR-...QG.FPLT....MLISTASQPGFTGSLDDVLqevl...........dghwDMIGg..dLDGALt..fsW.PDTEW........................DYEEAPEGR.EAFE.AN.......---HWKNFGAMLRSAGFPVPTTVRDLSELYLTWGIASREETpd.glRWSMPA.VLPLPGDLLPLDAELTARLDRMRWSTRTGPLVDQLIS.............H.............LADDLGE..P.EEILTSLDRLA.AATGKDADDVRLALTELVesg.............darvRRGEEPA-.....-DTERLEAHRRFRLLMDWDHLYETRMK-l.....................
A0A1Q9LCB7_9PSEU/14-268              .................................................gl--FREVFDGLGWGRFVPHA...AV.EVLGv..vVMLGCPTRDQV-GRLVGRT...................PDARa..gLAAPA.....W.EEFEPwtetsls.........taldgeppSPLDVDRAN.AEDR.AW.......LDRTIADVDRYADSLGVTHPRTTADVLDYLTACTVLLATTErg.evHYELNP.WAALPAEVLPLTRDQVREEDALRWIALHRPVVRKLIA.............L.............FGPYTDT..PiDALRTTLLDLA.ERCAADVESVRAAVSILA....................EQPDFCVK.....GNPERLAAGDLLEIRVDWANFIEYRLD-i.....................
A0A543B3X6_9ACTN/8-251               .................................................wa--LRMDWDQTGWCRFLPWE...GA.LLW-....RMFCEATECEVDGDLDELV...................D---....-----.....WySPLDPva...................fgpDFFGGLDAR.VEHR.RS.......-WSDRRRLSRLFGKAGIVYPQTARQIAEVGRMLGLYLKEEEp...qRWRAPA.ALPLPTEVLPMTPRQRQQEDEQRQHLLWSGPAAVIVE.............V.............LRDVGC-..P.ERVHTSVDELA.DLICEPSETVRQSLAFLNdtrfgghlgrplmklqttvaAGGNR--S.....ADPERLEGREEFQLVPNWQG--------laaty.................
K0ATS6_GOTA9/7-198                   ..................................................i-KVPGEISEYLWTRYLPET...TY.KVY-....ALIAYLNKKRA--------...................----....-----.....-.-----........................----ILDAQ.IEIE.NN.......IPRVIQEKKDILNKLGFKYPENRQEDIDLLLKYNLIEMSKDedgedIYVHVY.PIKRPQEVLNIDEEELKTLDNIKFEIKHEQALNMLFT.............L.............ILNNNGK..-.--LTCSVDHIT.KTTKVKLTEVKEVMNYLLs.................eeGSIKVTGN.....KDIKKLKKT-------------------ik....................
A0A2S4YVU0_9ACTN/16-248              ..................................................q-HFHSVI-GGGWLRMPPPM...LG.LLL-....AALTGRGRPLTRGELRPFV...................RNSVn..pSGDWQa..scW.ED---........................----RDERP.GKDL.AD.......LRAAQATSARYAAHYGLPPLSTLNDMLALMIAAGLVHEIPDadgqmRLYPTF.PLPGRHEVFPLDDEELSAQHALRRHHAYGGDSSRIIA.............L.............FEPTGLR..H.QEITTSLDRLA.GVIDGHSHDARQAVLLLL....................EGPDFTAT.....TDISEIAPHKVFQLRCDWDTFHEHRIR-r.....................
A0A5P0YP89_9ACTN/14-263              ...................................................MAMHNDWWLSGWEHVLPR-...QG.FPLT....MLIGTASQPGFTGSLDDLLheif...........dgrwDMIGg..dLDGALt..fsW.PNEEW........................DYEAAPEGR.EACE.AA.......---RWEEFSTMLTTAGFPVPQTVRDLSELYLTWGLATREETse.gtRWSMPA.ALPLPGDLLPLDPELTERLDGIRWTRRTGPLLDTLIA.............H.............LIDDLGE..P.AETLTSLDQLA.AATGQDVDDVRLALAELVtsg.............darvQRGEELA-.....-DAERLEAHRRFRLVMDWAHFHENRIQV......................
S4MZG9_9ACTN/29-79                   ..................................................l-VMHNDWWASGWDHVLPR-...QG.FPLP....MLIGTASQPDFTGSLDDLF...................R---....-----.....-.-----........................---------.----.--.......-----------------------------------------.....------.-------------------------------------.............-.............-------..-.-----------.------------------....................--------.....----------------------------rsskatg...............
A0A0L0WE48_GOTPU/7-223               ..................................................v-TIPIEINDYLWTRYMPET...TY.KVY-....ILIGYLNEQNIVGEEATKT...................----....-----.....-.-----........................----ILDAD.IEEK.NT.......IDKVLEQKKEVLGKLGLKYPENRQDDLDLLVNFKLINIDKDdegntVYKYNI.PVERPEEVLELDEEELKVLEDIKFELKHESALNMILT.............L.............IINNNNN..-.--LLCSVDHIS.KTTRVKIAEIREVMDYLVn.................keGSIKIKSD.....KPISKLKKNDKIYISVNEEVFEKKRLV-l.....................
A0A1W2F9R9_KIBAR/166-380             ..............dpgwdtvigshawelpyivsqagdqdgatiddvaawa-------------------...--.----....-------------------...................---V...aHHRPA....dW.LDERLfpvpa..............palptGHADLDEQA.TQSR.SSri...aeAAAEEAKLASYAAQLGVPAPTTRRGLLTFFVAAGLVTYDGR.....KYRRVS.SPPLAREVLRLPADLVTQLAMQSDRRQYQSFATDIAS.............V.............AAWLDGR..-.---AVTVGWLA.DQLLATQEEVRATLHY--....................--------.....----------------------------aqtqamlevtgdtelrmdv...
A0A1H8DHR0_9BACL/17-170              ..................................................v-CVPDGFFRNGWNLLLPKG...TCsVILS....VMSYVIQGLDKAEILDSMK...................----....-----.....-.EEEERlclt...............pfhfqIPHEFPTDE.EKE-.-Wy....msLWQREKDVKQILERSGLSYPQTVTQWIHLLVRLGIFLEVRRks.adYFDLVIePFPYPEEYLHLSGPELNWLYQQR--------------.............-.............-------..-.-----------.------------------....................--------.....----------------------------ksfp..................
A0A1M5SR25_9ACTN/14-263              ..................................................l-AMHNDWWASGWEHVLPR-...QG.FPLT....MLIGTASQPDFTGSLDELLqelf...........eghwDMIGg..dLDGALt..fsW.PDEEG........................DYEEAPEGH.EANE.AH.......---RWETFGAMLTAAGYPVPRTVRDLSELYLTWGLARREETpd.gtRWSMPA.ALPLPGDLLPLDADLAKRLDRIRWTLRTGPLVDGLIN.............H.............LVDDLGE..P.QEILTSLDRLA.AATSQDADDVRIALAELVqsg.............daqvQRGQEPA-.....-DAERLEVHQRFRLVMNWDHFHENRVQ-l.....................
A0A069RD05_PEPLI/7-222               ...................................................IKMPKEIHEYLWTRYLPET...TF.KLY-....VMVGYLQTEKIAGEQATAL...................----....-----.....-.-----........................----LLRAN.LPVE.NN.......NPAIIEEKKRILSSLGFEYPNNRKEDLELLLRFKLVTIVKNsegklEYMYTL.PVPKPEDVLEIGEEEKQALENIKFEIAHQNAFNMLLT.............L.............VLNNNGS..-.--LMSTVGHIE.NTTRVKISEIRSVLAFLEe..................eGSIKINAH.....KDVNSLKKADKVHVTINKEIFEQKRCV-l.....................
A0A6V8K2X3_9ACTN/4-228               ..................................................q-WQRAVMVPS-WIRWLPCS...FA.YLT-....---VVPDQHGFSRKAWSMLp.................wD---....--KAV.....W.CDPGSvddwva............qaqshhPRREADHAE.LQAR.EHydrvvrvRAARVELFTEMCRRRGLPVPHTLEELLSCLVGFGLFEM-DG.....EWLTPR.LEQNPIEVLPLAGNEIVDEERAQQDDRTVLVAITVRA.............L.............AERTRPR.wRrRQVTTDLRAFA.AALRMPEGEVRRSLARLV....................E-------.....----------------------------vagvhvhprrsplatg......
C0Z774_BREBN/14-239                  ..................................................v-VIPSSFAANGWTSVLSHE...MN.VLFQ....AMCYVVTKHESKEEMRKAL...................----....-----.....-.DEFDAl.....................kgTFTKPVQEG.FKSE.EDf....kgYVNLLNRFKSFMSRSEYAYPTSLDEAIELFVKWGLVIDNGD.....AWDVPVyPFPDASELFKLSEAESLALAHIKLEALVHPMFSRLVM.............K.............LHEQEEN..TfSMSKAEMKQLL.NTNDQMLAEVLIKLTPYM....................----EEAI.....ENMLEIPEDEKMNFTIVWERIYEDFLG-q.....................
A0A5Q2N311_9FIRM/22-145              ..................................................i-RIPSTFYEYNWPHYLPPT...AL.SLYR....ALCRIAETDLRGSRARYEL...................----....YDRPFt...pW.H----........................----AENTE.IEIN.QW.......------LLQKLCERKGWTFPANVTQSVDLLLKLSLIQVQVDeqgdeVYDIIL.PVPHPADILE---------------------------.............-.............-------..-.-----------.------------------....................--------.....----------------------------rpel..................
A0A317CY61_9ACTN/12-273              ................................................vpa------LFQLGWYRWLPLS...AM.DFEH....LLHRFPDLSRREAVQAQRVwdarragvdldnnlapdvlADSL....PAAPA.....W.PAAAR.......................pTGESGDEQA.YEEElAD.......QQRRIGEYDEVTTSLGIHPVRTAEQVLDLMITLGLIEVEAAde.geALRLAA.NPPLPTEVLPLSPEQRAEEDRLRWRSRYGALSQRVLR.............L.............FIHDASGglSrVTLPTSLDRLA.TAIGSDAEDVRHAVQVLI....................DEGDFSAQrqgapVDAERLVPHQRFDLVVDPSRFYADRIS-v.....................
A0A4R6IWG0_9ACTN/232-360             ..............................................nypsl-------------------...--.----....-------------------...................----....-----.....-.-----........................---------.----.--.......--------AEIAAQVGLREPRSRRELLPLFVALGVLTFDGS.....RYVGVE.RPPMVQDVLELPAAGVANLEAYQVTGQFTGYAADLVS.............V.............ALWDGAE..-.----QSIESLA.ARTIGSEDDVRGALQFAE....................--------.....----------------------------grgllridhqpedqf.......
A0A0C2AY35_9ACTN/14-263              ...................................................MAMHNDWWASGWDHVLPR-...QG.FPLT....MLIGTASQSGFAGSLDDLLqeif...........ggswDMIGg..nLDGALs..fsW.PDEEW........................DYIEAPEGR.EACE.AS.......---RWEEFGALLTAAGFPVPTTVRDLSELYLTWGLARRKETpd.gtRWSMPV.ALPLPGDLLPLGADLTARLDRIRWMWRTGPLVDSFIN.............Y.............LVDDLGE..P.QEVLTSLDRLA.AATGQTADDARIAIAELVqag.............dalvYRGQELA-.....-DAERLEAHRRFRLVMNWNHFHATRIT-l.....................
A0A1S1V5I0_9FIRM/3-215               ..................................................i-EIPRQIGDYLWTRYLPES...TY.KTY-....VLIGYLNNRELSAEDYSEE...................----....-----.....-.-----........................----LMNVG.LGED.KT.......LEKVVAEKRKVLEKLGIEYPENRTEDVALLKQFGLIEAVDG....gKYKYVE.EIKRPEEVLDLDEEEKSALEDIKFEVKHDRAINMILS.............L.............VLTNGKL..-.--LDCTVEHIT.NMTKVKIADIRTVLDFLVn.................keKSLRVQSS.....KDISKLKKGDRVRITVNEEVFNEKRFI-l.....................
A0A4R3L6R2_9BACL/17-177              .................................................iy--VPSGFFTYAWNLFLPHG...TC.SVLL....SVMTFIIHGYTKTEIVELM...................K---....-----.....-.-AEEKelsllp............fsfeipKFFECEEEK.EKFF.AI.......YERELA-VRHVLHRSHFKYPKTMIQWIHLLIQVGILGEVRReg.kiYLDMVVhPFPLPEDVLMMDELEVRQIHAYRKQAEL---------.............-.............-------..-.-----------.------------------....................--------.....----------------------------ymvtnr................
A0A3G8ZJ74_9ACTN/41-289              .................................................eg--IFDEWLALGWFSIAPS-...--.VLFS....ITEAARGLHFTRAELAESIal...............niEEHGyrelDSDPL.....W.LV--A........................DPETAADLE.LAEE.GGydaylegERTQRANWGELGSRSPKLAVTTVDEFIDLLCDWNLLVESDG.....VLELLD.PVPDPVDLLPLTNPEKDELLESREPSDFELVDGVLHA.............F.............IYHSDES..-.-TMVTTIGKLA.QQADVAPEMARLILAGIIasge...........sgltaDRFGPMEA.....EAITDLADHQKFTLVVDRDSDAIKHHA-h.....................
G2GP32_9ACTN/77-193                  ..................................................l-AMHNDWWASGWDHVLPR-...QG.FPLT....MLIGTASQPGFTGSLDELLqelf...........eghwDMIGg..dLDGTLt..fsW.PDEEW........................DCEEAPEGR.EANE.AH.......---RWEKFGAMLMAAGYPVPKTVRDLSELYLTWG-------.....------.-------------------------------------.............-.............-------..-.-----------.------------------....................--------.....----------------------------......................
G2GML9_9ACTN/1-133                   .............................................larree-------------------...--.----....-------------------...................----....-----.....-.-----........................---------.----.--.......----------------------------------------Tpd.gtRWSMPA.ALPLPGDLLPLDADLAQRLDGIRWTLRTGPLVDELIN.............H.............LVDDLGE..P.QEILTSLDRLA.AATGQDVDDVRLALAELVksg.............daqvQRGEEPA-.....-DAERLEAHRRFRLVMDWEHFHEKRIQV......................
A8MK06_ALKOO/5-220                   ..................................................v-RVPQEIHSYLWTRYLPET...AY.KTY-....ILIGYLQQENKTGKVAMDF...................----....-----.....-.-----........................----LLNAN.IKEE.NT.......IPQILQEKKDVLKKLGYEYPKNIKEDLDLLLSFQLIMEVADskgdtYYIQSI.PVPKLEEVLKLDDEEIKNLKNIRFEIDNQKGMDMILT.............M.............LLNGNGN..-.--LGVTLDYIY.KTTKVKLTEIRAVLSYLVd..................eGSISIRAN.....KAIDKLKKEDKLLIQINEAVFHQKRVV-l.....................
A0A373D9N6_9MICO/9-262               ..................................................q-TVTDILFGRGWSSTLPPA...VV.ILFGe..lASAGPITRTALDSMLRAEN...................PHTPd..gLDSSV.....W.EPLEPwteeklae.......ldedfgepdESRTADELN.AQDK.AQ.......RELDQADFARYLASKNLPVSHTFGALVDLLVSCNVLSANEA....gGLFLNP.HAPLPAEVLPLDAREAARQDKIRWERLHERTAQAIIR.............F.............FRTDEQE..V.DHILVSLDQLA.KELESDPEDVRSAVKVLT....................DEGDFSTS.....IDIERAHPQQSFVLHVDWDVFNRNRIHV......................
A0A2N0G283_9ACTN/17-249              ..............................................hylqq------VMRSGWSRMRPYS...LL.FLL-....LGVGIAENGATREDLKLGLrn...............sgNP-Qg..dLEAPC.....W.ED---........................----PDDLD.EDEQ.AR.......QPELIETAALYAAHHGRPPLRTHADVLDLLLAAGVVYELPDasgtpRIFPKV.PAPVPADVFPLDEEEAAVQRQLLIDSAYEGPSYRIIE.............L.............FEPDGLR..R.EEIVTSLDRLA.RLIGGDAQDAREAIRLLT....................EAGDFTTT.....LDVSNVPSHKVFRIQCDWDQFDQQRIS-i.....................
A0A6B2WTE8_9ACTN/37-134              ..............................................isrsv-------------------...--.----....-------------------...................----....-----.....-.-----........................---------.----.--.......-----------------------------------------.....------.------------------ERQLRIDSVYEGDSYRSIE.............L.............FDPDGQR..R.SEVKTSLDRVA.RLIEGDTHGRREALRLLT....................ETGDFTTS.....RDLTGLPPYRVFAIRRDGEQFDQQRIA-i.....................
A0A1Q4VM42_9ACTN/16-272              ..................................................l-CMHNDWFESGWPHVLPSH...QA.MWMA....MLFSTATVRQLEGDLDTIAvqvfgdd....pgrtprglGDQG....LESPV....aW.LDEES.......................lEAAGSQEEA.AEIT.ED.......ARVHRRRCEESLRAAGFPVPATVRELAAVMERLGITHRSGG.....YWSMPD.RFPRPEDVLPLSGEIADSLLGLRKFQAVDPVERALLD.............Y.............ATHTLGS..P.AQFSTSLQRLE.RATGFDADELRAALDHLVsrdg............eiqlHRGQPPAV.....IAAKDLTVHSRFQITLDWAGIDEARS--pv....................
A0A561BPJ4_9ACTN/225-367             ........................................rttvprdgypt-------------------...--.----....-------------------...................----....-----.....-.-----........................---------.----.--.......-------LAEIAAQVGRPEPTSRREMLTLFVALGVLTFDGT.....RYAGIA.EPRPAQQVLDLPADVVTYLDAHRATVQYTGFAADLVS.............V.............ALWGGTE..-.----QTVASLA.TRTLASEDQVRRALQYAE....................--------.....----------------------------srnllqidrrsgdrlaltatrr
M8DFU4_9BACL/15-240                  ..................................................v-AIPGAYAGHGWSNVLPHE...MN.VLFQ....ALCYAVTKGESKAEMREIV...................D---....----G.....F.EGLEG........................LFAEPTEDM.FNSK.EDf....enYKSLLERHKKVIVRSGYEYPKSREEAIALFERWGLLIDKGD.....VWDIPInPFPDALDTFELTEAEQYALRYVRFEALVHPFFARLVM.............T.............LHERDDE..SfTFTKAELKEML.NTNDSMLAEVLIKLTPYM....................----EEAI.....ENMLEIPEDEPMTFSIVWERVYEDFLG-q.....................
A0A061M1A9_9MICO/2-255               ..................................................q-TVTDILFGRGWSSTLPPA...VV.ILFGe..lASAGPITRTALDSMLRAEN...................PHTPd..gLDSSV.....W.EPLEPwteeklae.......ldedfgepdESRTADELN.AQDK.AQ.......RELDQADFARYLASKNLPVSHTFGALVDLLVSCNVLSANEA....gGLFLNP.HAPLPAEVLPLDAREAARQDKIRWERLHERTAQAIIR.............F.............FRTDEQE..V.DHILVSLDQLA.KELESDPEDVRSAVKVLT....................DEGDFSTS.....IDIERAHPQQSFVLHVDWDVFNRNRIHV......................
A0A5Q0H3T3_SACSY/178-345             .....aavwaardadgvttveavrrwserqhrgagwldgplpgpghreldp-------------------...--.----....-------------------...................----....-----.....-.-----........................---------.----.--.......--------ADVAAQLGVPAPTSPRDLLAVFAAAGLLVADGD.....AYRWPE.VEPRAQDVLDLSPERRAELVLWQESDRFRSLAADLVS.............V.............ALWGGAR..-.----QTVAALA.ARTLVAEDDVRDTLDWAV....................--------.....----------------------------rqglltvegplsg.........
A0A1C1A1E0_9BACL/22-157              .................................................ci--LPKGFYEYGWAEWLPLV...NI.STLP....QISYCVSKEFTREDTVQYL...................S-LH....KSNQL.....F.CNFEN.......................aDILFGTEYQ.INEY.YL.......IYSRELMIKENLKKNGFSYPNTMEEVIDLFLQLGFLIQQSDqsgniILDMVIrPFPKVTD------------------------------.............-.............-------..-.-----------.------------------....................--------.....----------------------------ki....................
A0A1U9ZYC1_9ACTN/96-286              .rtgwqavlglpcqevlhavqvaaaagnateeqiaaayqpwssssgdwsgp-------------------...--.----....-------------------...................----....-----.....-.-----........................---------.----.--.......---LAEDLSDYAVQLGVPAPATRQELLRLLVAAGLVITETSae.vtRYRPSA.SPPPVEEVLRLPDEQVTMIRRQDAFHRYTSFAADLAA.............V.............AVWSPG-..-.CTVSATLEELS.RQLLATEEEIHGAIRYGT....................ERGLFST-.....----------------------------sgdegvvmamprl.........
A0A4R7GZU5_9ACTN/14-64               ..................................................l-AMHNDWWASGWDHVLPR-...QG.FPLT....MLIGTASKPVSRAPWTTSF...................----....-----.....-.-----........................---------.----.--.......-----------------------------------------.....------.-------------------------------------.............-.............-------..-.-----------.------------------....................--------.....----------------------------mrsstatg..............
A0A6F8YS84_9ACTN/4-245               .............................................qwqral------MVPS-WIRWLPCS...FA.YLT-....---VVPDQHRFSRKAWSML...................---P....WDKAV.....W.CDPGSvddwva............raqrhhPRREADHAE.LHAR.EHydrvvrvRAARVELFTEMCRRRGLPVPHTLEELLSCLVGFGLFEM-DG.....EWLTPR.LDQNPIDLLPLAGDEILNEERAQRDDRTVLVAITLRE.............L.............AGRTRRR.wRrRQVTTDLHAFA.SALRMPEAEVRRALAHLG....................EIAGIQV-.....-DPPPAVARDRVRVTVAWPSFARRFP--fd....................
A0A6F8XK34_9ACTN/4-245               ...........................................rwqralmv--------PS-WIRWLPCS...FA.YLT-....---VVPDQHRFSREAWSMLp.................wD---....--KAV.....W.CDPGSvddwva............qaqrhhPRREADHAE.LHAR.EHydrvvrvRAARVEQFTEMCRRRALPVPHTLEELLYCLARFGLFEM-DG.....EWVTPR.LEQNPIEVLPLTGDEIVNEERAQQDDRAVLVAITVRA.............L.............AERTRPR.wRrRQVNADLSGFA.AALRMPEAEVRRALTRLG....................EIAGLQ--.....VNPPPAVARDRVRITVAWPSFARRFP--fd....................
A0A1A5PB39_9ACTN/14-263              ...................................................MAMHNDWWVSGWEHVLPR-...QG.FPLT....MLIGTASQPGFTGSLDDLLreif...........dghwDMIGg..dLDGALt..fsW.PDEEW........................DYEEAPEGR.EANE.AN.......---RWEKFGAMLTAAGYPVPRTVRDLSELYLSWGLACREETpd.giRWSMPA.ALPLPGDLLPLDPELTERLDGIRWTMRTGPLLDTLID.............H.............LVDDLGE..P.TETLTSLDRLA.AATGQDVDDVRLALAELVksg.............darvQRGEEPA-.....-DAERLEAHRRFRLVMDWEHFHENRIQV......................
A0A2W2D186_9ACTN/93-226              ...............................................lced-------------------...--.----....-------------------...................----....-----.....-.-----........................---------.----.--.......-----------LSELGVPAPTTRPELLRFLVAAGVVIAETSgg.vtRYRLPE.QPPRAEDVLRLPDERRAVIRRQDARRRYTRFVADLAA.............V.............AVWSRDH..-.-TVSATPAELS.GRMLATEEEIRETIAH--....................--------.....----------------------------giehgllspsgegaftatp...
A0A1Q9LMS7_9PSEU/26-256              ...........................................wlgellvn---------GGWVRFLPPG...VH.AVLH....PFC--RAREVTADEVAAAV...................----....LATGE....pW.GEVDLftaedfdem......carspldesGGRTVEQVN.AGIL.AD.......HEQRLAEVDGYAAQLGVAAPCTVGRALDYLVACGLLQRRGE.....RYRLNL.DPPDPSEVFELGEEARAWLRDCACRQR-WQVASAVMR.............L.............AEDPAG-..PlGRGWTTLRGLG.AHLATDIRTVRGALVVLL....................DDPDAVFD.....VDPDRVGEDQRFSFR-------------r.....................
A0A0C2QC08_9BACL/33-168              ..................................................c-VIPNQFYESGWGLWLPMP...NV.TLVPyfsnAIAIGLSRDDTIIYLENKI...................----....--KPN....tF.LDFEE........................AGITPTEFD.MDEK.QM.......LYEREKEIKRRLEANGYQYPKSINEAVSLYVTLGLAVEEVGeqgriCLDMLIrPLRKIDDVL----------------------------.............-.............-------..-.-----------.------------------....................--------.....----------------------------i.....................
A0A0U3NTS1_9ACTN/14-263              ...................................................MAMHNDWWTSGWEHVLPR-...QA.FPLT....MLIGTASQPDFTGSLDDLLqeif...........dgrwDMIGg..dLDGALt..fsW.PDEEW........................DYEEGPEGR.DANE.AK.......---RWETFGAMLTAAGFPVPQTVRDLSELYLTWGLASREETpd.gtRWSMPA.ALPLPGDLLPLDAELTKRLDGIRWMMRTGPLVDTLIN.............Y.............LVDDLAE..P.QEVLTSLDRLA.AATGRDADDVRLALTALVqag.............daqvYRGQEQA-.....-DAERLEAHRRFRLVMNWDHLYENRMH-l.....................
A0A6I4VYU6_9BACL/16-169              .................................................lq--VPAVFFELGWNLYLPQG...MN.SVVL....SVVTFIYQGYSKSEIFFYM...................E---....-----.....-.--EEAkklam..............epfplDKIHKQELMsYHVH.HE.......LYLREQWCESILVRSSLRYPTTISDMVQLLIDIGILIEVNYre.itYLDLILqPFPRPKESLVLTPEENDRA------------------.............-.............-------..-.-----------.------------------....................--------.....----------------------------kqqiqlfrl.............
A0A3N2PEV3_9ACTN/1-208               ................................................mvp-------------------...--.----....-------------------...................----....-----.....W.DESAWcdpgsvee.......wvaraqrrhGGRDAAHAE.LHAR.EHyawmvrvRATRIELFAEMCRRRDVPVPHTVGELLLCLARLGLFEVTDEgd.gdPWVRPR.LDRDPLDVLPLSPRERELELRAQRDDQAVLVAIAIRR.............L.............AQRTRRR.wRrRVVTTSLPNLA.NAAGVTVEQARRSLDDLA....................----EFTG.....LGVTPARSAEALRLTVPWPDFRLRFP--ft....................
A0A5C4W4F7_9ACTN/171-356             stgwrrclglpgqevlyavqlasatgeatedrvaaayqpwssgsggwgspl-------------------...--.----....-------------------...................----....-----.....-.-----........................---------.----.--.......----SEDLSDFAAQLGVPAPTTRLDLLPLLVAAGLLIAETAgg.ltRFRLAP.EPPRAEEVLDLPADQAAMIRRQDDHKRHTCFAADLAA.............L.............AVWSPGG..-.-VVTATPEELA.GRFLATAEEIRETIRYGV....................ERG-----.....----------------------------llsvpadatfta..........
A0A1I2MNF9_9ACTN/189-406             ...............................................ghgk---------NGWRNELPAP...IM.DVRRm.vgAVIAEWGRSVSVEDVDEWTr................thRHPSd..wLNAPL.....W.RPVSEplat................ghadRDRAVADRH.AQTL.AR.......LAAMRRRVDEIAAELRVPRVRSKPDVLPLLAAAGLLVRDEA....dRYSLGR.P-QRVDTVLSLPPERARFVQQADARSRYQQLAEDVLA.............V.............LRWTPEV..-.-QLETTPAELA.ERLLATKDQIHDVL----....................--------.....----------------------------kfaehtgllritmqqqr.....
A0A1M5S5B3_9FIRM/7-222               ...................................................IKMPTEIQEYLWSRYLPET...TF.KMY-....VMVGYLNAENIKGEKATNT...................----....-----.....-.-----........................----LLNAN.LTVE.RE.......IPQVTEEKKRVLEKLGYKYPETRKEDIELLLKYNLVRIAADkdgnlLYLYNT.PVPRPEEVLNLDEEELTILENIRFEIKHQHAFNMFLT.............L.............LLNSNGT..-.--LATTLDHIH.KTTKVKYSDLKEVLEFLEk..................eGSINIKAS.....KNVKNLRKNDKVYISINKEVFEQKRFV-i.....................
A0A1M6KEK4_9CLOT/7-222               ...................................................IHMPKEIHEYLWLRYLPET...TY.KMY-....IMIGYLQTEKIRGDEATKK...................----....-----.....-.-----........................----LLGAN.LKEE.NA.......IPKVIEEKKRLLKSLGFKYPENRQDDLKLLLDFNLIKIGKDkednvVYVYNI.PVPKPQDILKLNEEELQTLENIKFEIKYQNAFNMILT.............L.............LINNNGN..-.--LMSTLEHIQ.TTTKVKLTDIKLVLEYLVk..................eGSISVRTQ.....KDISKLKKADKIFIKINEDVFEEKRLV-l.....................
#=GC seq_cons                        ..................................................h....t.h...hW.phLP......h.h.h.....hhhhhhsp.thttph.t.h..........................................t............................ts.ctp..ttc.tp..........hhpphpphhpphGhshPpThp-hlcLhlshGLhhtpts.....haphsh.shPhPt-lLsLss-thtt.cph+hp.tht.hhttlhp.............h.............hh.s.tp......h.solppLu.ttht.t.p-lR.sLt.Lh..........................s.......s..th..tp.h.h.h............h.....................
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