GenomeNet

Database: Pfam
Entry: DUF6281
LinkDB: DUF6281
Original site: DUF6281 
#=GF ID   DUF6281
#=GF AC   PF19797.1
#=GF DE   Family of unknown function (DUF6281)
#=GF AU   Williams LS;0000-0001-5551-8526
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF AU   Fragoso S;0000-0001-7018-3891
#=GF SE   Manual
#=GF GA   28.00 28.00;
#=GF TC   31.20 31.10;
#=GF NC   25.60 23.80;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Domain_of_unknown_function
#=GF RN   [1]
#=GF RM   16766657
#=GF RT   Amplification of the entire kanamycin biosynthetic gene cluster
#=GF RT   during empirical  strain improvement of Streptomyces
#=GF RT   kanamyceticus.
#=GF RA   Yanai K, Murakami T, Bibb M;
#=GF RL   Proc Natl Acad Sci U S A. 2006;103:9661-9666.
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This entry represents a member of a biosynthetic gene cluster
#=GF CC   (BGC). This BGC (BGC0000703) is described by MIBiG as an example
#=GF CC   of the following biosynthetic class, saccharide, in particular
#=GF CC   the  kanamycin biosynthetic gene cluster from Streptomyces
#=GF CC   kanamyceticus  [1]. 
#=GF SQ   55
#=GS A0A6I3JDN0_9ACTN/23-122   AC A0A6I3JDN0.1
#=GS A0A1Q5KRG2_9ACTN/16-106   AC A0A1Q5KRG2.1
#=GS A0A2G9DR57_9ACTN/166-265  AC A0A2G9DR57.1
#=GS A0A0X3XIE5_9ACTN/24-109   AC A0A0X3XIE5.1
#=GS E8WC62_STRFA/30-130       AC E8WC62.1
#=GS A0A1V1W7A6_9ACTN/28-127   AC A0A1V1W7A6.1
#=GS A0A2U2ZZH0_9ACTN/28-106   AC A0A2U2ZZH0.1
#=GS A0ABW0_STRA7/42-141       AC A0ABW0.1
#=GS A0A077MCB5_9MICO/112-203  AC A0A077MCB5.1
#=GS A0A494V5H7_9ACTN/44-143   AC A0A494V5H7.1
#=GS C9Z5H2_STRSW/31-135       AC C9Z5H2.1
#=GS A0A5B8EMP6_9ACTN/24-116   AC A0A5B8EMP6.1
#=GS A0A5Q0NV96_9ACTN/80-171   AC A0A5Q0NV96.1
#=GS A0A089X7I2_STRGA/28-121   AC A0A089X7I2.1
#=GS A0A1Q4V7G3_9ACTN/16-116   AC A0A1Q4V7G3.1
#=GS Q82EY3_STRAW/39-138       AC Q82EY3.1
#=GS A0A4S2V0J9_9ACTN/13-113   AC A0A4S2V0J9.1
#=GS A0A101N912_9ACTN/26-111   AC A0A101N912.1
#=GS A0A233RNP3_9ACTN/9-104    AC A0A233RNP3.1
#=GS A0A0M9X7H7_9ACTN/33-132   AC A0A0M9X7H7.1
#=GS K4R5C2_STRDJ/28-126       AC K4R5C2.1
#=GS A0A1E5PK33_9ACTN/22-121   AC A0A1E5PK33.1
#=GS A0A0X3UYT3_9ACTN/34-118   AC A0A0X3UYT3.1
#=GS A0A504CNE9_9RHIZ/15-115   AC A0A504CNE9.1
#=GS A0A2P8Q8W7_9ACTN/23-135   AC A0A2P8Q8W7.1
#=GS A0A1C4KGI2_9ACTN/31-128   AC A0A1C4KGI2.1
#=GS A0A0F5VSG6_9ACTN/23-106   AC A0A0F5VSG6.1
#=GS A0A0L0KNM4_9ACTN/27-125   AC A0A0L0KNM4.1
#=GS A0A5Q0NVG6_9ACTN/24-123   AC A0A5Q0NVG6.1
#=GS A0A124IFM0_9ACTN/38-138   AC A0A124IFM0.1
#=GS A0A4Q5J8Y6_9ACTN/28-130   AC A0A4Q5J8Y6.1
#=GS A0A1A5P2V5_9ACTN/32-131   AC A0A1A5P2V5.1
#=GS A0A0Q7C3N8_9ACTN/1-88     AC A0A0Q7C3N8.1
#=GS A0A4R7IT95_9ACTN/36-133   AC A0A4R7IT95.1
#=GS Q82CN8_STRAW/69-168       AC Q82CN8.1
#=GS A0A5N8WG93_9ACTN/8-108    AC A0A5N8WG93.1
#=GS A0A0L8L444_9ACTN/35-137   AC A0A0L8L444.1
#=GS A0A4Q2T7B0_9ACTN/21-120   AC A0A4Q2T7B0.1
#=GS A0A0Q6V4T3_9ACTN/30-119   AC A0A0Q6V4T3.1
#=GS A0A0Q8DK06_9ACTN/32-134   AC A0A0Q8DK06.1
#=GS A0A6I3J212_9ACTN/29-123   AC A0A6I3J212.1
#=GS A0A2G9DR57_9ACTN/29-136   AC A0A2G9DR57.1
#=GS C9Z5H2_STRSW/167-266      AC C9Z5H2.1
#=GS A0A5C4VP26_9ACTN/19-118   AC A0A5C4VP26.1
#=GS A0A1H4XR63_9ACTN/34-118   AC A0A1H4XR63.1
#=GS A0A1M7HSH6_9ACTN/28-113   AC A0A1M7HSH6.1
#=GS A0A2I0SN56_9ACTN/38-137   AC A0A2I0SN56.1
#=GS A0A5N8WCY0_9ACTN/38-142   AC A0A5N8WCY0.1
#=GS A0A4Q4ZCV1_9ACTN/24-114   AC A0A4Q4ZCV1.1
#=GS A0A117P7V4_9ACTN/32-116   AC A0A117P7V4.1
#=GS A0A2M9JHQ0_9ACTN/44-143   AC A0A2M9JHQ0.1
#=GS A0A498B489_9ACTN/36-135   AC A0A498B489.1
#=GS A0A5J6FIT8_9ACTN/15-114   AC A0A5J6FIT8.1
#=GS A0A4R1AFI3_9ACTN/21-116   AC A0A4R1AFI3.1
#=GS A0A0F5W4H1_9ACTN/32-130   AC A0A0F5W4H1.1
A0A6I3JDN0_9ACTN/23-122              .......sp--SSADCSAQIRVADVVYTSH.-GS.TSR.....DATRHGR.ADEAQ..CHDIGPDAGGSv....faDDPAQVRTWTFEGYSPDEVLgVKYGTNGFGVFV---..ADTVQPDQRERIY--ae.........................
A0A1Q5KRG2_9ACTN/16-106              .........GEGAASCAYVVTYQGHAYVGA.ENV.DFE.....VGERIGT.AAQPP..CDDTPNDDDPG.......SPATTLNAYRVVGWDTATAI.AVGRSPDDVVFTRMD..PELELP---------...........................
A0A2G9DR57_9ACTN/166-265             .........GASTAKCAFVLEYDGESYIGR.AAE.DLA.....MGAKVGT.ARAMH..CDDTPGDTDAT.......PAPEVYEAYEIKGLDPADAIaVRRSADEEPVFL-TR..LGEELPPEVEE----rfae.......................
A0A0X3XIE5_9ACTN/24-109              ......gea--GEASCSGLVTYDGRGYLPT.AKS.GFT.....VGERLGT.ATVAA..CEDTPNDPETG.......LPEATTGVYTVEGADPTEAV.AVGDDPSTAAYMTA-..---------------r..........................
E8WC62_STRFA/30-130                  .........GGGAASCVARYTYQEVTYQDV.GDV.EFT.....PGKKLGV.ATEPP..CEDTGGGAGSD......ePAGLTGTAYEVDGISPKVAI.AVGDTPEIAKFFAVS..SGAELPPEVRKLIDG...........................
A0A1V1W7A6_9ACTN/28-127              .........GETAGDCSLQIRHDGDTYTSY.---.GFTd...rEGTRYTP.ADEAS..CEDVGEHPRGSv....fsEDAPRVTTWTFSGYSPDDVLgVRFDADSFTVYV---..ADSVAPDERDRIFE-e..........................
A0A2U2ZZH0_9ACTN/28-106              .......sg--GSASCAGLVTYDNRDYLPT.EKS.VFT.....VGERLGT.ARVAE..CAD-------D.......VPESRTGAYRIEGTDPAEGI.AVGDSATEAAPMAV-..---------------hr.........................
A0ABW0_STRA7/42-141                  .........GEAEESCAIAALYGGRTYTQV.ANV.DFA.....VGEALGP.AEFPP..CDDTPGHDDDD.......AGPEPVTAYAVDGLDPRIAI.AMRYTPDEIMLLAAQ..PGGSLPPEVEALLR-g..........................
A0A077MCB5_9MICO/112-203             ........g-GGMMSCVAAVNYRGRTYYGV.GDVrRFP.....VGQALPEgASMPG..CNDTGGAPE--.......-PATPLAAQSIPDVSPDKAI.MTEG-----------..---------------siwvadldavpaeikallk........
A0A494V5H7_9ACTN/44-143              .......dg--QAASCAYLVHYQDRSYQDV.ANV.EFT.....AGEELGS.ATVPP..CDDTGGQEDAE.......QAEDTVTAYRVDGISPDVAV.AVGDSPDDTVFVVAY..SGGELPPEVQKLIDR...........................
C9Z5H2_STRSW/31-135                  .........GTSSASCVFAVDYDDRTYVDA.GKV.RHT.....LGAEVGT.ARDSV..CEDQGGGEEDRv....apGDLGDYTAYAIKGVDTEDAI.AVRDSPEGEVRVVVR..MGG------------dggvretaerlfgk.............
A0A5B8EMP6_9ACTN/24-116              .....rged-----PCPSTYEFDGRTYVAHeTTA.EVT.....PRDALGS.GTETG..CGDGG------.......PYTSEMAMHDVDGVDPRVAV.VSPVNARAIYLARGA..EVSDLTPEVAA----vvl........................
A0A5Q0NV96_9ACTN/80-171              .........GGGAASCAFEVRWEGRVYSGI.GEQ.ARMp...ePGRALGT.GVVPG..CDDGNGESR--.......--DVDVTLHALGDRDPAEAV.VTADGE---------..---------------vlaprdgtvpadlrelld.........
A0A089X7I2_STRGA/28-121              .........GDAAASCAYLVRYEGRTYLDR.SGV.GFE.....AAERIGT.AVLPP..CDDTPGDGEPG.......SPPTSVRAYRVVGWDPAEAI.AVGTSPRDAVFVAVS..PDEASP---------rpg........................
A0A1Q4V7G3_9ACTN/16-116              .....gdgr---AESCAYRVLYQDRTYRDV.ANV.EFT.....AGRRLGS.ATVPP..CEDTGDPDNAE.......EPGETTTAYAVDGISPDVAV.AVGDSPGDAALVAAY..SGNKLPPEIQKLIDG...........................
Q82EY3_STRAW/39-138                  .........GVSAGSCDDVMEFDHRTYLSV.GDV.EFT.....VGAEAGA.AGRPP..CDDTGGESEEE.......-TRFDMTAYEVEGLDTGVAI.AVGDSPHGARLYAMY.eEDGDLPAEVQKFIG-g..........................
A0A4S2V0J9_9ACTN/13-113              .........GGAEASCVARYTYQDLTYQDV.GNV.KFT.....AGKKLGV.ATAPP..CEDTGGRSETE......ePAGAAEAAYEVDGMSPEVAI.AVGDTPETARFFAVS..SDSELPPEVQELIEG...........................
A0A101N912_9ACTN/26-111              .........GGSAASCAGVVSFEGRRYLPS.GRT.DFT.....AGERLGT.ATVAA..CDDTPGDDEVA.......VPEDTTAAYAVEGRDRAEAV.AVGDTPAEARLMEVQ..---------------r..........................
A0A233RNP3_9ACTN/9-104               watsvmdtk-------------EGRTYRDV.ANV.EFT.....VAGKLGA.ATKPP..CDDTGGPDEGH.......VPATTKIAHAVDGISPKVAI.AVGDTPDDVTFVAVY..SGNKLPPEVKKLIN-a..........................
A0A0M9X7H7_9ACTN/33-132              .........GEQAAACAYRVRYQDRTYRDV.AGV.RFT.....AGEELGS.ATLPP..CDDTGGRDDTG.......QAGETTTVHRVDGIPPEVAV.AVGNGPGDTTFVAAY..SGGELPPEVRKLIDG...........................
K4R5C2_STRDJ/28-126                  .........GEAAASCAYVIDYDNRHYSDV.ANI.DYR.....LGEKLGT.ATQPP..CDDTPGHGDDG.......EPAHRITAYAVQGLDPAIAI.AVGDAPDDVILVAVR..EGGELPPEIDKL---pr.........................
A0A1E5PK33_9ACTN/22-121              .........GESASTCAFMVEYDKRRYIAD.-NT.DIS.....VGDELGA.ASRPP..CDDTPNDNSDG......kTTASSTTAYTVEGVDPALAI.AVGDSPDDVRLVVID..SGKELPPEIKKMIN-r..........................
A0A0X3UYT3_9ACTN/34-118              .........GEAAASCSGLVTYDNRGYLPT.TDT.DFT.....VGERLGT.ATIVE..CDDTPNDPGVG.......IPESRTGAYTVRGSDPADAI.AVGDSAAEARLMKV-..---------------r..........................
A0A504CNE9_9RHIZ/15-115              .........GGGAASCVARYTYQEVTYQDV.GDV.EFT.....PGKKLGV.ATEPP..CEDTGGGAGSD......ePAGLTGTAYEVDGISPKVAI.AVGDTPETAKFFAVS..SGAELPPEVRKLIDG...........................
A0A2P8Q8W7_9ACTN/23-135              .........GGSAASCAFAVQFRGELYTRV.KHA.DFT.....VSDALGS.SRRTL..CDDTGSDPSSGtigtvgtVGTETYTTYRIEELDAGTAV.AVRDTPANA------..---------------grrdglnlyvlqldggppddakrflde
A0A1C4KGI2_9ACTN/31-128              ........v-EGVSDCPLVIRFDGHEYGSApPGI.AFA.....LAERLGP.AVQPP..CGGPAESEE--.......---VPHTAYRVRGLDPGVALaVRPEGDGTAYLVAAR.rADGKLPAEVERLAR-t..........................
A0A0F5VSG6_9ACTN/23-106              .........GEASASCSGLVTYDSRDYLPT.EKS.VFT.....VGERLGT.ATIAE..CDDTPNDSGDG.......IPESRTGAYRIEGVDPAVGI.AVGDSAAEAA-----..---------------pmaa.......................
A0A0L0KNM4_9ACTN/27-125              .........GDSAASCAFVADFDGRRYSDL.AGA.EFT.....LGKAVGT.AVLPT..CDDTGGDDDPG.......IAAREVRAYSVAGVDPSVAI.-VVDRSTETLLVAMS..VRNQLPMEVRKLVT-r..........................
A0A5Q0NVG6_9ACTN/24-123              ........s-QTSGDCSAQVRADGIVYTSH.-GY.TER.....KASRHSV.ADQAD..CDDVGEDAAGSv....fgEHPQQVTTWAFRGYPPEDVVgVRLDKNSFAVFV---..ADSVPDTERERI---yrd........................
A0A124IFM0_9ACTN/38-138              .........GDSAASCVFLAEYANRTYSDV.ANV.DFT.....VGDELGT.ATLPT..CDDTPNDNDDG......eTAPAVTTAYAVEGLDPSIAI.AVGEAPDDVVFVAVR..SGTEIPPEVQKLIDG...........................
A0A4Q5J8Y6_9ACTN/28-130              ......psa---AYECTPEIRFDGVVYSAY.-DY.TDQ.....GATKFGT.ADEAD..CHDVGREAPGSv....fpNDPRQVAVWTFGGYTSEQVLgVRFGPDSFMVFIADS..VPRDQAEHIS-----rtlrk......................
A0A1A5P2V5_9ACTN/32-131              .........GEQGASCAYRVLYRDRTYRDV.ANV.EFT.....AGEKLGP.ATIPP..CDDTGGQDEGE.......QAGETTTVYEVDGISPEVAV.AVGDAPGDVIFVAAH..LGDKLPPEIRKLING...........................
A0A0Q7C3N8_9ACTN/1-88                ........m-------------DGVLYTSV.-GP.THR.....QASRYAS.AEKAE..CHDTGRDPGGSv....faDDPERLDTWAFDGYPPTKVLgVRWYGNDLGVFI---..ADAVPAEERERI---hed........................
A0A4R7IT95_9ACTN/36-133              .........GESAGSCAYRMIYEGRTYGDV.ANV.DYE.....IGEKLGT.VTSPP..CDDTPNDDD--.......ASVQSSTAYAVRGLDPSVAI.AVGGAPDDTLFLVVD..SARTLPPEVRELIDG...........................
Q82CN8_STRAW/69-168                  .........GASASSCAYLVEYQSRTYAGS.AAR.DFT.....LGDELGA.ATLPP..CDDTPNDDSDG......rTTPTSTTAYAIEGVDPAIAI.ALEQSSDDVIFIDVD..SDWTLP-EIKKMIHG...........................
A0A5N8WG93_9ACTN/8-108               .......dg--GSASCAIVVTYEGRTYQDI.GAV.DVPv...eTTGELGR.ATHPP..CNDTGGEEDDE.......-ESWESPAYAVKGVDPTVAI.AVGGSPEDATLVAVD..EVEDLPAEVRELLDG...........................
A0A0L8L444_9ACTN/35-137              ...gdsarp---APSCAYVVDYDGRSYLGR.GET.DVP.....VGKSLGS.ATRQA..CDDTPGDGDDG.......EGPALMTAFAVRGVDPAVAI.AVAEDTDAYRLVVAD..GVEELPPELEKVTD-r..........................
A0A4Q2T7B0_9ACTN/21-120              ........s-ESSADCPDQVRLEGVVYTWN.-GV.TSR.....DATRHAS.ADRAE..CDDAGEDPEGLv....fpDDPVEVQTWTFEGYSPAQVLgLRYDDGSFGVLI---..ADDVAADEQRRI---rad........................
A0A0Q6V4T3_9ACTN/30-119              .........GQSECSCAAGVTYDKTFYQQY.ANT.SVH.....AEAAIGK.SDVADdcCGD--------.......-SVRQVTVYSIEGVDPTIAI.ATKDADGITYFN---..VASELAKHDQKIAD-r..........................
A0A0Q8DK06_9ACTN/32-134              .......ep--STADCSSQVRIGERVYTSH.---.GFTe...rAATRFAK.ADVAE..CQDTGCDPKGSv....fsGEPTQMTVWSFEGYSTDQVVgTRFDDDSFAVFV---..ADSVSDQEAERLL--qelas......................
A0A6I3J212_9ACTN/29-123              .........GGGEASCAAVLEIDGRTYLGH.GDL.RREp...aVTGRNLE.ALVPG..CDDTGGQDDPE.......-PARTARAQELADVPAAVAV.LL-DGS---VYV--R..EGEDLPP--------aarawfds...................
A0A2G9DR57_9ACTN/29-136              .........GESSASCAFVVDYRDSQYVDV.GRV.EYA.....LGSKVGS.ARQAI..CEDQGGGEEDAada.vaaEDRTVYTAYAIKGVDPADAI.AVRESPGGELSVMVDprEDEPLPDAADRIFG-r..........................
C9Z5H2_STRSW/167-266                 .........GADVGKCALVVEYGNEEYIGR.GDA.RIE.....LGARAGL.ARAVP..CWDTPGEVDPS.......AEPQAYRAYEIKGLDPADAI.AIRFSADEKPFFMVR..VGDDLPPEVEALL--aa.........................
A0A5C4VP26_9ACTN/19-118              .......er--SAGDCDAVIRVENRTYTAV.TMT.NDK.....PAEKFAT.AQMGR..CEDVGASPPGVv....fdGDVDQVQSWVFEGYDSDVVL.GVRVSDSWQVFV---..EDSVTEAERE-----givsa......................
A0A1H4XR63_9ACTN/34-118              .........GTAAASCAYMVTYADRTYLGT.ADT.DFT.....VGKKLGT.ATVPE..CDDTPNDPEGA.......VPEGRVTAYAVEGTDPAVAI.AVGDTPAEATLMKV-..---------------h..........................
A0A1M7HSH6_9ACTN/28-113              .......ga--GGRDCAWQLHYDGRLYVMA.PGQ.ESAkvvphQGDPVGQ.GYFDG..CQDGGGAE---.......-PRQPVGVYRVAGVDPTLAV.ITQD-----------..---------------dviavtdpahv................
A0A2I0SN56_9ACTN/38-137              .........GDSASSCAYRVEYENRTYTGA.EAK.GFA.....PGDKLGT.ATLPA..CDDTPDDDNDG......qATPTSTTAYAIKGVDPGIAI.ALKESSDDVIFINLD..SDTELP-EIKKLIQG...........................
A0A5N8WCY0_9ACTN/38-142              .......ge-QGEASCAFVVEFEKHRYRHL.DIT.EFT.....AGSQIGT.AAVPV..CDDTGGGRDAVsr...eeEEQEVYRAYEITGLDTSDAI.AVRYAPDDEPSFMAR..TGEELPPEVRKLLD-e..........................
A0A4Q4ZCV1_9ACTN/24-114              .......sg--DAASCAALIRYDGHDYLGT.GEL.RRTp...aTTGRTLR.AAVPG..CDDTGEQGP-A.......PHDEAVRVEELAGIDPDVAV.LW-------------..---------------ngavfvrrgrmlppstrv.........
A0A117P7V4_9ACTN/32-116              .........GAAEALCAYLVTYDHRTYRDV.ANV.DFT.....VGEKLGT.ATIPE..CDDTPNDPGDT.......VPERRITAYEVEGMDPAAAI.AVGDSPAEAILMKV-..---------------h..........................
A0A2M9JHQ0_9ACTN/44-143              .........GEAEGACAIAATYGGRTYTQV.ANV.DFT.....VGKALGP.AEFPP..CDDTPGHNDDA.......AGPKPTTVYAVDGLNPRIAI.AMRYTSDEVMLLAVQ..PGGSLPPEVKALTR-g..........................
A0A498B489_9ACTN/36-135              .........GGAASSCAFLVEYEGRTYQDV.ADI.PFT.....VGEELGE.AVVPA..CDDTPNDGDDG.......VPRSATTAYAVAELDPAIAV.AVGDGPGDVRLVVVR..RGGELPSEVRELIG-g..........................
A0A5J6FIT8_9ACTN/15-114              .........GEGEASCAFEVTYQGRTYRDV.ANV.DFT.....VTGELGT.VLQPP..CDDVGGQEETE.......GKGTEENAYAVKGLPPKTAI.AVGGSPGDAVFVVSY..SGSTLPPEVRKLIDG...........................
A0A4R1AFI3_9ACTN/21-116              .......sa--SRSGCAVEIELDGVRYEGY.NAE.DVV.....AGEPLGE.GVIVA..CEDGAGKAEDD.......----PVDLVSVKGGDPAEVI.ARDGVTDELFLAPGV..EPDDLPAGVRKML--gr.........................
A0A0F5W4H1_9ACTN/32-130              .........GDSSASCAYRILYQDRTYEDV.ADA.TFK.....AGGKLGT.ATHPA..CDDTGGQDETL.......-PADTMTAYEVDGVPTELAI.AVGDTPADARLVAVY..SNKELPPEVQKLIDG...........................
#=GC seq_cons                        .........GtuuuSCAhhlpY-sRsYtss.uss.cFs.....sGc+LGs.Ashss..CDDTsscscss........sspsssAYslcGlDPshAI.AVt-ssspshhlhs....stplPsEhpch...t..........................
//
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