#=GF ID   Exotox-A_bind
#=GF AC   PF09101.14
#=GF DE   Exotoxin A binding
#=GF AU   Sammut SJ;0000-0003-4472-904X
#=GF SE   pdb_1ikp
#=GF GA   20.50 20.50;
#=GF TC   20.50 21.20;
#=GF NC   19.80 19.70;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 -Z 75585367 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF CL   CL0004
#=GF RN   [1]
#=GF RM   11734000
#=GF RT   Refined crystallographic structure of Pseudomonas aeruginosa
#=GF RT   exotoxin A and its implications for the molecular mechanism of
#=GF RT   toxicity. 
#=GF RA   Wedekind JE, Trame CB, Dorywalska M, Koehl P, Raschke TM, McKee
#=GF RA   M, FitzGerald D, Collier RJ, McKay DB; 
#=GF RL   J Mol Biol. 2001;314:823-837.
#=GF DR   INTERPRO; IPR015185;
#=GF DR   SCOP; 1ikp; fa;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   Members of this family are found in Pseudomonas aeruginosa
#=GF CC   exotoxin A, and are responsible for binding of the toxin to the
#=GF CC   alpha-2-macroglobulin receptor, with subsequent internalisation
#=GF CC   into endosomes. The domain adopts a thirteen-strand antiparallel
#=GF CC   beta jelly roll topology, which belongs to the Concanavalin
#=GF CC   A-like lectins/glucanases fold superfamily [1].
#=GF SQ   5
#=GS TOXA_PSEAE/27-275         AC P11439.2
#=GS A0A6B2U1E7_9ACTN/14-82    AC A0A6B2U1E7.1
#=GS A0A0J6NSS9_9NEIS/2-260    AC A0A0J6NSS9.1
#=GS A0A3N4AZ09_YERPE/337-417  AC A0A3N4AZ09.1
#=GS A0A0X8GM05_9BURK/54-312   AC A0A0X8GM05.1
TOXA_PSEAE/27-275                    ................EEAFDLWNECAKACVLDL.KDGVR-SSRMSV-DPAIADTNGQGVLHYSMVLEGGNDALKLAIDNALSITSDG--LTIRLEG---------GV------EPNKP.V.RYSYTRQARGSWSLNWLVPIGHEKPSNIKVFIHELNAGNQLSHMSPIYTIEMGDELLA--KLARDATFFVRAHESNEMQPTLAISHAGVSVVMAQAQPRREKRWSEWASGKVLCLLDPLDGVYNYLAQQRCNLDDTWEGKIYRVLAGNP----AKHDLDIKPTVISHRLHF.............
A0A6B2U1E7_9ACTN/14-82               ...........graev------------------.------------------------------------------------------------------------------------.-.-------------VDWLAALGDRGPGEVRERIDSMELAWLVHQVEQRYELELDDDQLDRIKTIDDAVFVLA----------------------------------------------------------------------------------------------------ealksh.......
A0A0J6NSS9_9NEIS/2-260               ..............kt--DFEIFKQCADNCILSPaEPGKFISTSLPL---QITPSPDEGVLYYSMFVQDR---FTTAANNS-ATIKIDDFAKVRINDGQGTGHAP-GTLTIELATPDGKvK.KFTHKRR-TEWFTLNWAVPIGKDAPTSIKLFIMDMDSNKKIVDHSPLYSVDLDDAALARWPDKAKLAFSSANPRND-----IILSWPGVGYTAAPAQHNRQKRWSEWHSGILLCWLDPLDAIYNYVTQNRCQLNKTWEGALYKVVAGKP-QINEFKPLAKAP--IQHRVHF.............
A0A3N4AZ09_YERPE/337-417             nsdvifdinnvdansp------------------.------------------------------------------------------------------------------------.-.---------------------------------------------------------------------------------------IVIDKMVLTVGKEHNRAERSTLGLATCWAIPILSIYNYIVQGHCNQADKFVH--------------------------------naadffgspadki
A0A0X8GM05_9BURK/54-312              ..............kt--DFEIFKQCADSCILSPsEPGKFISTSLPV---QITPSPDEGVLYYSMFVQDR---FASAANNS-ATIKIDDFAKIRINDGYDTGSAP-GSLTIELATPDGQ.VkKFTHKRR-TEWFTLNWAVPIGKDAPTSIKLFIMDIDSNKKIVDHSPLYSVDLDDAALARWPAKAKLAFSSANAMN-----DIILSWPGVGYTAAPTQHSRQKRWSEWHSGILLCWLDPLDAIYNYVTQNRCQLKNTWEGSLYKVVAGNPQ-INEFKPVAKAP--IQHRVHF.............
#=GC seq_cons                        ..............cs..sF-lappCAcsClLs..csGhh.Sophsl...tIssosspGVLaYSMhlpst...ht.AhsNu.uhhp.s..hplRlps.........Gs......pPst..h.+aoapRp.pt.aoLNWhVPIG+-uPosIKlFIh-h-uspplschSPlYol-LDDstLARh.stschsFssAs..s......lhlSasGVuhshA.sQtpRpKRWSEWpSGllLCWLDPLDuIYNYlsQsRCpLscTWEGtlY+VlAGpP....th+slshtP..IpHRlHF.............
//