#=GF ID FAN1_HTH
#=GF AC PF21315.1
#=GF DE FAN1, HTH domain
#=GF AU Bateman A;0000-0002-6982-4660
#=GF AU Chuguransky S;0000-0002-0520-0736
#=GF SE ECOD:EF17486
#=GF GA 27.00 27.00;
#=GF TC 27.00 27.00;
#=GF NC 26.80 26.90;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 -Z 75585367 --cpu 4 HMM pfamseq
#=GF TP Domain
#=GF CL CL0123
#=GF RC Paper describing PDB structure 4r89
#=GF RN [1]
#=GF RM 25319828
#=GF RT Crystal structure of a Fanconi anemia-associated nuclease
#=GF RT homolog bound to 5' flap DNA: basis of interstrand cross-link
#=GF RT repair by FAN1.
#=GF RA Gwon GH, Kim Y, Liu Y, Watson AT, Jo A, Etheridge TJ, Yuan F,
#=GF RA Zhang Y, Kim Y, Carr AM, Cho Y;
#=GF RL Genes Dev. 2014;28:2276-2290.
#=GF RC Paper describing PDB structure 4rea
#=GF RN [2]
#=GF RM 25500724
#=GF RT Structural insights into 5' flap DNA unwinding and incision by
#=GF RT the human FAN1 dimer.
#=GF RA Zhao Q, Xue X, Longerich S, Sung P, Xiong Y;
#=GF RL Nat Commun. 2014;5:5726.
#=GF RC Paper describing PDB structure 4ri8
#=GF RN [3]
#=GF RM 25430771
#=GF RT DNA repair. Mechanism of DNA interstrand cross-link processing
#=GF RT by repair nuclease FAN1.
#=GF RA Wang R, Persky NS, Yoo B, Ouerfelli O, Smogorzewska A, Elledge
#=GF RA SJ, Pavletich NP;
#=GF RL Science. 2014;346:1127-1130.
#=GF RC Paper describing PDB structure 4ry3
#=GF RN [4]
#=GF RM 25547363
#=GF RT Crystal structure of human Fanconi-associated nuclease 1.
#=GF RA Yan PX, Huo YG, Jiang T;
#=GF RL Protein Cell. 2015;6:225-228.
#=GF RC Paper describing PDB structure 5y7g
#=GF RN [5]
#=GF RM 29514982
#=GF RT Structural mechanism of DNA interstrand cross-link unhooking by
#=GF RT the bacterial FAN1 nuclease.
#=GF RA Jin H, Roy U, Lee G, Scharer OD, Cho Y;
#=GF RL J Biol Chem. 2018;293:6482-6496.
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC FAN1 is a DNA structure-specific nuclease involved in the
#=GF CC processing of DNA interstrand crosslinks (ICLs). It maintains
#=GF CC genomic stability and prevents tissue decline in several organs.
#=GF CC This protein possesses preferential endonuclease activity toward
#=GF CC 5' flap structures [1-5]. FAN1 is present in most eukaryotes and
#=GF CC some bacterial sequences. It consists of four characterised
#=GF CC domains: UBZ, SAP, TPR and VRR nuclease (Pfam:PF08774). However,
#=GF CC monocellular eukaryote and bacterial homologues lack the UBZ
#=GF CC domain [1]. The N-terminal helical domain of FAN1 can be
#=GF CC subdivided in a winged-helix (WH) DNA-binding domain,
#=GF CC represented in this entry, and a SAP domain (bacterial
#=GF CC Pfam:PF18081 and eukaryotic Pfam:PF21169) [1-5].
#=GF SQ 2195
#=GS A0A8B7ZPE9_ACAPL/561-645 AC A0A8B7ZPE9.1
#=GS A0A4Q4V9A0_9PEZI/142-222 AC A0A4Q4V9A0.1
#=GS A0A7K6JI61_9CORV/371-455 AC A0A7K6JI61.1
#=GS A0A2P6QVG6_ROSCH/302-383 AC A0A2P6QVG6.1
#=GS A0A257D3G5_9PSED/17-98 AC A0A257D3G5.1
#=GS A0A5B0FSA0_9BACT/30-111 AC A0A5B0FSA0.1
#=GS A0A673UKG1_SURSU/382-466 AC A0A673UKG1.1
#=GS A0A654E0C9_9BACT/21-102 AC A0A654E0C9.1
#=GS A0A0D3LCU0_9BACT/14-95 AC A0A0D3LCU0.1
#=GS A0A858QXN4_9GAMM/18-101 AC A0A858QXN4.1
#=GS A0A0L8HWY7_OCTBM/349-433 AC A0A0L8HWY7.1
#=GS A0A1M5VPN9_9GAMM/7-87 AC A0A1M5VPN9.1
#=GS A0A851RJ91_CERFA/397-481 AC A0A851RJ91.1
#=GS A0A851DGX1_TODME/397-481 AC A0A851DGX1.1
#=GS A0A1V6P731_PENDC/115-194 AC A0A1V6P731.1
#=GS A0A4Y9YCL5_9APHY/49-130 AC A0A4Y9YCL5.1
#=GS A0A1S9AJM1_9BURK/9-90 AC A0A1S9AJM1.1
#=GS A0A4W5QLD9_9TELE/331-415 AC A0A4W5QLD9.1
#=GS A0A848HPB2_9BURK/9-90 AC A0A848HPB2.1
#=GS A0A674KAI9_TERCA/411-495 AC A0A674KAI9.1
#=GS A0A1I6H233_9GAMM/20-102 AC A0A1I6H233.1
#=GS A0A2R9C9I5_PANPA/373-457 AC A0A2R9C9I5.1
#=GS A0A8C0VIZ8_CYACU/399-483 AC A0A8C0VIZ8.1
#=GS H2NMN3_PONAB/373-457 AC H2NMN3.3
#=GS A0A091EUN2_CORBR/371-455 AC A0A091EUN2.1
#=GS A0A7K6HSF6_9PASS/373-457 AC A0A7K6HSF6.1
#=GS R7U2X2_CAPTE/149-233 AC R7U2X2.1
#=GS A0A7L1DTW5_OENON/396-480 AC A0A7L1DTW5.1
#=GS A0A8B9DMK1_ANSCY/396-480 AC A0A8B9DMK1.1
#=GS A0A811YG28_NYCPR/385-469 AC A0A811YG28.1
#=GS A0A328DUX8_9ASTE/370-450 AC A0A328DUX8.1
#=GS A0A8C4CH11_9TELE/313-397 AC A0A8C4CH11.1
#=GS A0A4U6UTW7_SETVI/84-164 AC A0A4U6UTW7.1
#=GS A0A1P8AVS5_ARATH/290-370 AC A0A1P8AVS5.1
#=GS A0A5N6M8U0_9ASTR/347-428 AC A0A5N6M8U0.1
#=GS A0A1G9A0X1_9GAMM/17-98 AC A0A1G9A0X1.1
#=GS A0A432ZYS8_9FUNG/192-276 AC A0A432ZYS8.1
#=GS A0A3D8SFS4_9HELO/127-206 AC A0A3D8SFS4.1
#=GS A0A0D9WME5_9ORYZ/352-430 AC A0A0D9WME5.1
#=GS A0A841EW93_9BACT/11-92 AC A0A841EW93.1
#=GS G7E1L8_MIXOS/47-125 AC G7E1L8.1
#=GS A0A1R4I129_9GAMM/17-98 AC A0A1R4I129.1
#=GS A0A1M5F8N2_9ALTE/8-89 AC A0A1M5F8N2.1
#=GS A0A833QHG1_9POAL/349-429 AC A0A833QHG1.1
#=GS A0A5N7BLN1_9EURO/129-210 AC A0A5N7BLN1.1
#=GS A0A167DM61_METRR/129-210 AC A0A167DM61.1
#=GS A0A6J0KIH4_RAPSA/253-333 AC A0A6J0KIH4.1
#=GS A0A2T6E9G0_9GAMM/14-95 AC A0A2T6E9G0.1
#=GS A0A3S3MIJ5_9MAGN/390-470 AC A0A3S3MIJ5.1
#=GS A0A6A4WQL1_AMPAM/129-215 AC A0A6A4WQL1.1
#=GS A0A251QYX7_PRUPE/356-437 AC A0A251QYX7.1
#=GS A0A439CWM3_9PEZI/145-226 AC A0A439CWM3.1
#=GS A0A835U2F6_9PASS/403-487 AC A0A835U2F6.1
#=GS A0A0E0L8F7_ORYPU/409-485 AC A0A0E0L8F7.1
#=GS A0A7N6BEL2_ANATE/340-424 AC A0A7N6BEL2.1
#=GS A0A8C1DRN2_CYPCA/329-413 AC A0A8C1DRN2.1
#=GS A0A5E8A7Q9_9BACT/11-92 AC A0A5E8A7Q9.1
#=GS S3CXE1_GLAL2/137-218 AC S3CXE1.1
#=GS A0A8J6A715_GALPY/492-576 AC A0A8J6A715.1
#=GS A0A1I7I4W0_9GAMM/18-99 AC A0A1I7I4W0.1
#=GS A0A2N4UF33_9BURK/11-92 AC A0A2N4UF33.1
#=GS A0A7K5HS19_CROSL/397-481 AC A0A7K5HS19.1
#=GS A0A063Y8B7_9GAMM/15-96 AC A0A063Y8B7.1
#=GS A0A091JHT2_EGRGA/372-456 AC A0A091JHT2.1
#=GS A0A363RRS6_9BURK/7-88 AC A0A363RRS6.1
#=GS A0A507DSH5_9FUNG/101-181 AC A0A507DSH5.1
#=GS A0A6C0U1Z5_9GAMM/16-97 AC A0A6C0U1Z5.1
#=GS B3RR70_TRIAD/446-530 AC B3RR70.1
#=GS A0A6P8IYZ3_ACTTE/361-444 AC A0A6P8IYZ3.1
#=GS A0A397YCL1_BRACM/269-349 AC A0A397YCL1.1
#=GS A0A518EPB2_9BACT/10-91 AC A0A518EPB2.1
#=GS A0A852B351_9CORV/397-481 AC A0A852B351.1
#=GS A0A8E2FFH3_9PEZI/133-213 AC A0A8E2FFH3.1
#=GS A0A1N6ZPM8_9GAMM/10-89 AC A0A1N6ZPM8.1
#=GS A0A1I7VZE5_LOALO/282-368 AC A0A1I7VZE5.1
#=GS A0A1P8R741_9GAMM/18-99 AC A0A1P8R741.1
#=GS U3II60_ANAPP/396-480 AC U3II60.2
#=GS A0A6J8EKN0_MYTCO/357-441 AC A0A6J8EKN0.1
#=GS A0A7K5XXY5_9CHAR/400-484 AC A0A7K5XXY5.1
#=GS A0A840RE23_9NEIS/15-96 AC A0A840RE23.1
#=GS A0A8R7UZF3_TRIUA/355-435 AC A0A8R7UZF3.1
#=GS A0A8C0G8M8_CHEAB/364-448 AC A0A8C0G8M8.1
#=GS A0A7K4JNV8_GEOCA/398-482 AC A0A7K4JNV8.1
#=GS A0A125A0D1_9PSED/10-91 AC A0A125A0D1.1
#=GS A0A8V5HBX8_MELUD/390-474 AC A0A8V5HBX8.1
#=GS A0A4R5DZZ0_9BACT/21-102 AC A0A4R5DZZ0.1
#=GS A0A2J7PE50_9NEOP/827-908 AC A0A2J7PE50.1
#=GS A0A1S3ETK6_DIPOR/352-436 AC A0A1S3ETK6.1
#=GS A0A5F7ZAM4_MACMU/372-456 AC A0A5F7ZAM4.1
#=GS A0A183DT34_9BILA/60-146 AC A0A183DT34.1
#=GS A0A5J9TM15_9POAL/347-427 AC A0A5J9TM15.1
#=GS A0A853FWI0_9BURK/11-92 AC A0A853FWI0.1
#=GS A0A364L0F5_9EURO/129-208 AC A0A364L0F5.1
#=GS A0A7L1F6T7_SYLBO/373-457 AC A0A7L1F6T7.1
#=GS A0A7W7KI85_9PSED/9-90 AC A0A7W7KI85.1
#=GS A0A0C3HR38_9PEZI/89-169 AC A0A0C3HR38.1
#=GS A0A167HMT5_CALVF/66-150 AC A0A167HMT5.1
#=GS A0A3D8SDB4_9EURO/128-209 AC A0A3D8SDB4.1
#=GS A0A7K6GMA3_9PASS/397-481 AC A0A7K6GMA3.1
#=GS A0A7L2Q8L2_9PASS/399-483 AC A0A7L2Q8L2.1
#=GS J5K8C0_BEAB2/126-207 AC J5K8C0.1
#=GS A0A7K5KSA9_VIRAL/400-484 AC A0A7K5KSA9.1
#=GS A0A7N5JK17_AILME/381-465 AC A0A7N5JK17.1
#=GS FAN1_AILME/381-465 AC D2HNY3.2
#=GS S8C7N0_9LAMI/129-209 AC S8C7N0.1
#=GS R1H0G0_BOTPV/127-206 AC R1H0G0.1
#=GS A0A5F8GNI4_MONDO/413-497 AC A0A5F8GNI4.1
#=GS A0A5J4YZW5_PORPP/136-229 AC A0A5J4YZW5.1
#=GS A0A6D2KKD5_9BRAS/286-366 AC A0A6D2KKD5.1
#=GS A0A1V8ULL5_9PEZI/163-242 AC A0A1V8ULL5.1
#=GS M2YPI3_PSEFD/136-217 AC M2YPI3.1
#=GS A0A6I9L2L3_PERMB/364-448 AC A0A6I9L2L3.1
#=GS A0A2K2DQ85_BRADI/293-373 AC A0A2K2DQ85.1
#=GS A0A167EH51_9PEZI/156-235 AC A0A167EH51.1
#=GS A0A3D8JZ16_9BURK/8-89 AC A0A3D8JZ16.1
#=GS A0A8J2LW92_9BILA/271-357 AC A0A8J2LW92.1
#=GS A0A8H6RM78_9PEZI/136-215 AC A0A8H6RM78.1
#=GS G4U616_NEUT9/157-238 AC G4U616.1
#=GS A0A7L1H136_9PICI/376-460 AC A0A7L1H136.1
#=GS A0A7D5IG80_9PSED/9-90 AC A0A7D5IG80.1
#=GS A0A3D8Y3R4_9BACT/23-104 AC A0A3D8Y3R4.1
#=GS A0A851ZKR5_CALOR/401-485 AC A0A851ZKR5.1
#=GS A0A7C8IAT2_9PLEO/129-208 AC A0A7C8IAT2.1
#=GS A0A2T9YB15_9FUNG/226-303 AC A0A2T9YB15.1
#=GS A0A8J4ZKF0_9CHEL/137-221 AC A0A8J4ZKF0.1
#=GS A0A2N5Y786_9GAMM/16-97 AC A0A2N5Y786.1
#=GS A0A1S2CHC0_9GAMM/16-98 AC A0A1S2CHC0.1
#=GS A0A453QV43_AEGTS/287-367 AC A0A453QV43.1
#=GS A0A090T1F4_9VIBR/12-93 AC A0A090T1F4.1
#=GS A0A8C5JMJ7_JUNHY/397-481 AC A0A8C5JMJ7.1
#=GS A0A093R2X3_PYGAD/320-404 AC A0A093R2X3.1
#=GS E3BMI7_9VIBR/10-91 AC E3BMI7.1
#=GS A0A370NCN7_9BURK/10-91 AC A0A370NCN7.1
#=GS A0A179G300_METCM/129-210 AC A0A179G300.1
#=GS A0A2Y9K521_ENHLU/381-465 AC A0A2Y9K521.1
#=GS F9G611_FUSOF/128-209 AC F9G611.1
#=GS A0A7L1TMM3_PHANI/398-482 AC A0A7L1TMM3.1
#=GS A0A179UP14_BLAGS/119-199 AC A0A179UP14.1
#=GS W9RXE6_9ROSA/375-455 AC W9RXE6.1
#=GS A0A7R9QDH6_9ACAR/106-190 AC A0A7R9QDH6.1
#=GS A0A6I9SWG0_SESIN/344-424 AC A0A6I9SWG0.1
#=GS A0A1Y0IEJ5_9GAMM/8-89 AC A0A1Y0IEJ5.1
#=GS A0A2K8L0F0_9GAMM/9-90 AC A0A2K8L0F0.1
#=GS A0A7K8JY11_9GRUI/348-432 AC A0A7K8JY11.1
#=GS A0A2I0VTQ1_9ASPA/328-408 AC A0A2I0VTQ1.1
#=GS A0A6J3LUA3_9PEZI/135-215 AC A0A6J3LUA3.1
#=GS L8Y853_TUPCH/436-520 AC L8Y853.1
#=GS A0A150GRQ7_GONPE/62-140 AC A0A150GRQ7.1
#=GS A0A674GPB0_TAEGU/388-472 AC A0A674GPB0.1
#=GS A0A1M5PKC9_9BURK/9-90 AC A0A1M5PKC9.1
#=GS A0A8C3IZX2_9CHAR/396-480 AC A0A8C3IZX2.1
#=GS Q1QXF8_CHRSD/37-118 AC Q1QXF8.1
#=GS A0A319E7G6_ASPSB/124-204 AC A0A319E7G6.1
#=GS A0A178F623_TRIRU/117-198 AC A0A178F623.1
#=GS A0A8J4PC36_APTPA/397-481 AC A0A8J4PC36.1
#=GS A0A6P6BTP1_PTEVA/374-458 AC A0A6P6BTP1.1
#=GS A0A8C3FV30_CHRPI/411-495 AC A0A8C3FV30.1
#=GS A0A8C5GE56_9TELE/203-287 AC A0A8C5GE56.1
#=GS A0A3M7NCK4_9EURO/130-211 AC A0A3M7NCK4.1
#=GS A0A6J2I9V4_9PASS/388-472 AC A0A6J2I9V4.1
#=GS A0A8E2JFZ9_9PEZI/133-212 AC A0A8E2JFZ9.1
#=GS C5GD44_AJEDR/119-199 AC C5GD44.1
#=GS A0A369H0C3_9HYPO/78-157 AC A0A369H0C3.1
#=GS A0A2U1LCZ0_ARTAN/254-335 AC A0A2U1LCZ0.1
#=GS A0A166UP47_9HYPO/132-212 AC A0A166UP47.1
#=GS A0A1B8CET0_9PEZI/117-197 AC A0A1B8CET0.1
#=GS B8MFL4_TALSN/130-211 AC B8MFL4.1
#=GS A0A8C7I5Z0_ONCKI/421-505 AC A0A8C7I5Z0.1
#=GS A0A1U7LJP8_NEOID/14-92 AC A0A1U7LJP8.1
#=GS A0A4R3ICD8_9GAMM/9-90 AC A0A4R3ICD8.1
#=GS A0A061EJH4_THECC/291-371 AC A0A061EJH4.1
#=GS A0A7N0SZ37_KALFE/186-266 AC A0A7N0SZ37.1
#=GS A0A5C8ZXH4_9GAMM/11-92 AC A0A5C8ZXH4.1
#=GS A0A485PFS1_LYNPA/383-467 AC A0A485PFS1.1
#=GS R0IGW1_9BRAS/290-370 AC R0IGW1.1
#=GS A0A4W2C745_BOBOX/380-464 AC A0A4W2C745.1
#=GS A0A4U0QDF1_9NEIS/9-90 AC A0A4U0QDF1.1
#=GS A0A8H7PZ94_MORIS/116-197 AC A0A8H7PZ94.1
#=GS L8IIH5_9CETA/411-495 AC L8IIH5.1
#=GS A0A6P3ZYE8_ZIZJJ/241-321 AC A0A6P3ZYE8.1
#=GS G4NCQ4_MAGO7/136-217 AC G4NCQ4.1
#=GS A0A8C2YQL8_CHILA/374-458 AC A0A8C2YQL8.1
#=GS A0A8C4R3J4_EPTBU/448-500 AC A0A8C4R3J4.1
#=GS A0A1G9IM97_9GAMM/56-137 AC A0A1G9IM97.1
#=GS A0A099YTR1_TINGU/375-459 AC A0A099YTR1.1
#=GS A0A8D2M2K4_ZONAL/398-482 AC A0A8D2M2K4.1
#=GS A0A0D1W823_9EURO/153-233 AC A0A0D1W823.1
#=GS A0A261TRI2_9BORD/7-88 AC A0A261TRI2.1
#=GS A0A1X6NM85_PORUM/104-188 AC A0A1X6NM85.1
#=GS A0A093C2R1_9AVES/345-429 AC A0A093C2R1.1
#=GS A0A5A9NZ89_9TELE/355-439 AC A0A5A9NZ89.1
#=GS A0A1J7H3Y6_LUPAN/336-416 AC A0A1J7H3Y6.1
#=GS A0A8H5RD58_9HYPO/124-205 AC A0A8H5RD58.1
#=GS A0A3M2RC76_9GAMM/17-99 AC A0A3M2RC76.1
#=GS A0A7L0RCN9_GLABR/397-481 AC A0A7L0RCN9.1
#=GS A0A0F5VHC7_9GAMM/12-93 AC A0A0F5VHC7.1
#=GS A0A4Z2JAF1_9TELE/352-436 AC A0A4Z2JAF1.1
#=GS A0A8H7EEJ3_9PLEO/129-209 AC A0A8H7EEJ3.1
#=GS A0A5N6DLZ0_ASPPA/128-209 AC A0A5N6DLZ0.1
#=GS A0A8H7SKK9_9FUNG/71-152 AC A0A8H7SKK9.1
#=GS A0A7L4GBT2_PODST/387-471 AC A0A7L4GBT2.1
#=GS A0A8C6MM23_MOSMO/419-503 AC A0A8C6MM23.1
#=GS A0A7L2EUV0_QUIME/371-455 AC A0A7L2EUV0.1
#=GS A0A0H2S5N0_9AGAM/54-135 AC A0A0H2S5N0.1
#=GS A0A7K7TM31_9CHAR/391-475 AC A0A7K7TM31.1
#=GS A0A5N6UA23_9EURO/130-211 AC A0A5N6UA23.1
#=GS A0A2U2HMK6_9BURK/9-90 AC A0A2U2HMK6.1
#=GS A0A1V8SF33_9PEZI/190-269 AC A0A1V8SF33.1
#=GS A0A814I9R8_9BILA/84-167 AC A0A814I9R8.1
#=GS A0A673HKS7_9TELE/316-400 AC A0A673HKS7.1
#=GS A0A093ESQ0_TAUER/372-456 AC A0A093ESQ0.1
#=GS A0A2T0VHY6_9GAMM/17-98 AC A0A2T0VHY6.1
#=GS A0A2B7ZGL8_9EURO/105-186 AC A0A2B7ZGL8.1
#=GS A0A0D0A9P7_9AGAM/1-74 AC A0A0D0A9P7.1
#=GS A0A1B8D9W8_9PEZI/117-198 AC A0A1B8D9W8.1
#=GS K4KQ04_SIMAS/11-95 AC K4KQ04.1
#=GS A0A6G0XJE1_9STRA/17-95 AC A0A6G0XJE1.1
#=GS A0A7L2WXG3_PANHA/398-482 AC A0A7L2WXG3.1
#=GS A0A7L2I8G1_9PICI/395-479 AC A0A7L2I8G1.1
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A0A2P5I1B6_9PEZI/159-240 .........................i--YVDAFNLALDTV...L..E..D...E..A..H....L..F..DQ.KE..I.AI.FDQW.........R.G.LD.Y...............EAQYLYVRLFL.R.K.........vA......A...W.H.RR.D.K.L..G...Y..H.sD..I.S.D....PD...A.A.I.A...TLQRC----rtl.......................
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A0A2K6BYG2_MACNE/373-457 .........................p-YYLRSFLVVLKTV...L..E..N...E..D..Dm..mL..F..DE.QE..K.GI.VTQF.........Y.Q.LS.V...............TGQKLYVRLFQ.R.K..........L......S...W.I.KM.T.K.L..E...Y..E..E..I.A.S...dLT...P.V.I.E...ELKNAGFL-q.........................
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A0A8H5LI72_9AGAR/51-131 .........................l--YVKVFEDMVNVI...M..E..K...E..T..H....L..L..SD.AE..W.DM.LKVY.........R.K.LD.Y...............RVRYLLVRLVF.R.Q..........P......D...W.H.AL.S.S.L..D..kY.sA..E..I.G.E....EEl.aE.A.L.K...TL-------cvp.......................
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A0A6J2UMH0_CHACN/203-287 .........................p-YYLRNFLTILDTV...L..E..N...E..D..Dk..eL..F..NT.ED..L.SV.IHAF.........Q.Q.LS.A...............PGQMLYVRLFQ.R.K..........L......K...W.L.QV.D.K.L..D...Y..A..E..V.G.S...nLT...P.I.I.Q...DLVRHGFL-q.........................
A0A0F4QSQ0_9GAMM/8-89 .........................k-YYLTHFNELHGFI...A..K..T...S..L..H....L..L..SP.VQ..Q.ML.LREL.........A.S.LD.E...............DCLCLLLRIIN.R.K..........R......V...F.V.TR.A.Q.L..N...Y..A..E..I.N.D....ID...A.A.L.L...ALARNGLI-s.........................
H3BGJ1_LATCH/384-468 .........................p-YYLCNFLMVLQTV...M..N..H...E..D..Dr..qL..F..NE.KE..I.KN.INKF.........H.Q.LS.A...............AGQKLYVRLFQ.R.K..........L......N...W.I.KV.N.K.L..E...Y..T..E..I.G.S...dLV...P.V.I.E...ELVQADLL-q.........................
A0A0D2BDR2_9EURO/150-231 .........................i--YVDAFNLALNTV...L..E..D...E..G..H....L..F..NE.AE..H.SL.FKIW.........Q.K.LD.Y...............EAQYLYVRLFL.R.K..........T.....sK...W.F.RV.K.D.L..Q...Y.yS..D..V.A.D....ID...A.A.V.L...ELQKQ----rpl.......................
A0A2I0RS71_9PEZI/121-200 .........................i--YVDAFNLALETV...L..E..E...E..S..H....L..F..DE.AE..H.AV.FKRW.........R.E.LT.Y...............EAQYLYVRLFL.R.K..........T.....sS...W.H.RV.N.R.L..G...Y..H.sD..I.A.D....LQ...K.A.V.E...ELQ------lvr.......................
A0A8C8C0I4_ONCTS/426-510 .........................p-YYLGNFLTVLEAV...L..E..N...E..D..Dr..mL..F..NQ.ED..L.SA.IHGF.........E.R.LS.V...............TGQKLYVRLFQ.R.K..........R......K...W.L.QV.N.K.L..N...Y..N..E..I.S.T...dLG...P.V.A.Q...ELVEGGFL-q.........................
A0A067MYH5_9AGAM/48-129 .........................m--YVQLFQEILTTV...L..E..H...E..S..F....L..L..SE.SE..R.KL.LSRY.........S.D.MP.Y...............AARYLLVRLSL.R.K.........rA......K...W.H.RY.D.A.LytS...Y.aS..E..I.G.P...hLK...D.A.M.A...QLC------vs........................
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A0A157S4L1_9BORD/7-88 ..........................YYYLHNFQQALDWL...A..A..R...Y..A..D....V..L..GP.AE..Q.EF.LRAF.........P.A.LP.M...............ASRALLVRLLM.R.R..........H......T...V.F.RA.Q.R.L..Q...Y..E..E..I.G.A....VA...P.A.A.E...PLLALGWL-r.........................
A0A3P8XKY7_ESOLU/458-542 .........................s-YYLRNFLTVLEAV...L..E..N...E..D..Dr..mL..F..NP.ED..L.SA.IHKF.........K.C.LS.V...............PGQKLYVRLFQ.R.K..........L......K...W.L.QV.N.K.L..V...Y..P..E..I.S.T....EL..gP.V.T.R...ELVEGGFL-q.........................
A0A667WKV5_9TELE/352-436 .........................p-YYLRNFRTVLEAV...L..E..N...E..D..Dr..aL..F..NQ.DD..M.SL.IHTF.........E.K.LS.V...............MGQKLYVRLFQ.R.K..........L......K...W.L.QV.N.K.L..D...Y..E..E..I.C.S...dLG...P.V.A.Q...ELVQSGFL-q.........................
W9X9K0_9EURO/153-235 .........................i--YVDAFNLALDTV...L..D..E...E..A..H....L..F..ND.SE..L.SL.FGVW.........R.D.LS.Y...............EAQYLYVRLFL.R.K..........T.....sK...W.F.RV.K.D.L..Q...Y.yS..D..V.A.D....ME...A.A.V.A...ELQKER---llp.......................
A0A7L0ABF9_9CORV/369-453 .........................p-YYLQNFLVVLRAV...L..E..N...E..D..Di..rL..F..NE.QD..L.NV.IIKF.........Y.K.LS.V...............GGQKLYVRLFQ.R.K..........L......N...W.L.KV.N.K.I..E...Y..E..E..I.S.V...dLS...P.I.I.E...ELAEARFL-q.........................
A0A291P378_9GAMM/18-99 ..........................FYYLANFQCVLDWV...A..A..R...H..D..D....L..L..IE.PE..R.AF.LADF.........P.A.LP.R...............ASRALLVRMVM.R.K..........G......E...H.F.RT.S.R.L..A...Y..D..E..I.G.D....IE...E.A.L.S...PLVAAGWVE..........................
K6YN60_9ALTE/7-88 .........................k-YYLTHFQEFLAFI...S..G..P...C..A..H....L..L..SN.ED..S.AF.IGKF.........H.T.LC.E...............DAQCLYVRGLN.R.K..........S......S...I.I.KR.A.S.L..L...Y..D..E..I.N.H....HQ...I.H.I.E...ELLAQGF--yn........................
A0A839T140_AZOMA/9-90 ..........................FYYLDNFRQVLAWI...G..E..H...H..G..D....L..L..ED.AE..R.TL.LDRF.........P.Q.LP.Q...............NAQALLVRMVM.R.K..........G......T...L.F.RA.S.R.L..S...Y..T..E..I.G.C....PQ...A.A.A.S...PLLAEGWI-g.........................
A0A8D2H5R4_UROPR/378-462 .........................p-YYLXNFHMVLKAV...L..E..N...E..D..Dm..mL..F..DE.EE..K.GI.ISKF.........H.Q.LS.A...............SGQKLYVRLFQ.R.K..........L......S...W.I.KM.N.K.L..E...Y..E..E..I.A.S...dLI...P.V.I.E...ELKHAGFL-q.........................
A0A8C5TWU5_9PASS/393-477 .........................p-YYLQNFLVVLRTV...L..E..N...E..D..Dv..rL..F..NE.QD..L.NI.ITKF.........Y.K.LS.V...............GGQKLYVRLFQ.R.K..........L......N...W.L.KV.N.K.I..E...Y..G..E..I.S.V...dLS...P.I.I.E...ELAEARFL-q.........................
A0A6J0VV31_ODOVR/378-462 .........................p-YYLRSFLVVLKAV...F..E..N...E..E..Dr..mL..F..DE.HE..K.GI.VTKF.........H.Q.LS.A...............NGQKLYVRLFQ.R.K..........F......G...W.I.KV.N.K.L..A...Y..E..E..I.S.A...dLT...P.V.V.G...ELTHAGFL-q.........................
A0A1C3EPS4_9GAMM/13-94 ..........................FYYLSNFETLIDFV...S..R..Q...Y..L..D....L..L..NT.EE..Q.QW.LESY.........A.S.LS.R...............DGKALTVRFLS.R.R..........S......D...W.F.RR.D.K.I..S...Y..Q..E..I.D.D....ID...K.T.L.E...ELQLAGVV-n.........................
A0A8C6RMI0_NANGA/367-451 .........................p-YYLRSFLMVLQAV...L..Q..N...E..D..Dm..mL..F..DE.QE..K.GI.ITRF.........Y.Q.LS.A...............SGQKLYVRLFQ.R.K..........L......T...W.I.KM.S.K.L..E...Y..E..E..I.G.P...dLT...P.V.I.E...ELKLSGFL-q.........................
A0A2D2M7H3_9PSED/10-91 ..........................FYYLHNFQQVLDWL...L..L..R...Y..A..D....L..L..SE.QE..H.DF.IHQF.........G.Q.QP.Q...............AARAMLVRMVM.R.K..........G......Q...L.F.RE.S.K.L..E...Y..A..E..I.G.P....SA...E.A.L.A...PLVALAWVD..........................
A0A409Y3F6_9AGAR/49-130 .........................a--YVDVFENVAKTV...I..E..H...E..R..H....L..L..SD.DE..L.QF.LEHF.........S.E.LC.Y...............NARYCLVRLTL.R.K.........pG......Q...W.H.TV.S.S.L..E...-..-..-..-.-.-....--...-.-.-.-...---------kfkkeveedglqsaiadlckp.....
A0A061EK28_THECC/346-426 .........................k--YQENFCLLLQEV...L..R..S...S..P..H....L..F..TD.DE..K.KF.IESF.........T.S.LS.E...............DSRRLFVRLYT.R.K..........G......P...W.F.RL.S.T.I..M...Y..P..E..V.C.N....CQ...Q.A.V.K...ELSANGYI-c.........................
A0A1S3E0H0_CICAR/281-362 ........................vk--YQQNFCLMLQEV...L..R..N...N..I..H....L..L..TE.DE..K.TY.IESF.........T.S.LS.N...............DSQRLFIRLYT.R.K..........G......P...W.F.RM.S.N.I..S...Y..P..E..I.L.D....AQ...K.A.V.K...DLAEKEFV-c.........................
W6XY16_COCCA/129-208 .........................l--YVDAFNLALDTV...L..D..E...E..G..H....L..F..DE.AE..T.KV.FRIW.........R.S.LG.Y...............EVQYLYVRLFL.R.K..........T......S..aW.H.RL.K.N.L..G...Y..H.dD..I.S.D....LD...A.A.A.E...TLQH-----ty........................
A0A1I2JR36_9BACT/9-90 .........................k-YYLTNFWYLLDFV...Q..K..K...S..M..P....L..L..QE.RE..L.NF.IRLF.........Q.T.LS.E...............DAQCLFIRFVN.R.R..........K......I...F.F.KT.K.Q.L..R...Y..A..E..I.A.D....IP...N.A.L.N...ELIEKQFI-s.........................
A0A1G9RB46_9BACT/12-93 .........................r-YYLEYFEYVLRFV...Q..E..Q...Y..Q..S....T..L..ST.DE..F.LF.LERF.........A.A.LS.E...............DARCLFVRMAN.R.R..........G......L...F.F.RP.D.R.F..E...Y..A..E..I.D.H....LP...D.A.L.A...ALLDAGFA-e.........................
A0A067DIZ3_CITSI/287-368 ........................ik--YQCNFNLLIQEV...L..G..N...S..R..H....L..F..KA.DE..I.DF.LESF.........S.M.LS.E...............DSQRLFVRLYM.R.K..........G......P...W.F.RL.S.N.I..S...Y..P..E..V.S.N....SR...E.A.V.R...ELIDNGYI-c.........................
A0A2N7WZQ9_9BURK/9-90 ..........................LYYLHNFERALAWL...G..Q..R...Y..D..D....L..L..DA.SE..R.AF.LAEF.........P.R.LP.L...............NSRALLVRMLM.R.K..........G......M...L.F.RT.S.R.L..T...Y..E..E..V.G.C....PV...A.A.A.A...PLTVLGWVD..........................
A0A183M556_9TREM/27-109 ......................tyav----ESINDVLIML...S..R..Ds.gF..S..E....L..F..SE.SE..Q.KW.FENF.........R.N.LS.N...............LSKSLIIRLYG.R.S..........Q......K...I.F.RK.S.D.L..M...-..-..-..-.-.-....--...-.-.-.-...---------kiipndidqclrelnglrfl......
A0A0N0XHB4_9NEIS/9-90 ..........................FYYLDNFRVLLNWI...S..A..R...Y..A..D....L..L..LP.AE..L.AF.VDGF.........A.R.LP.H...............ASQALLVRMVM.R.K..........G......E...W.F.RA.G.K.L..N...Y..A..E..I.G.D....TR...A.A.A.Q...PLLAAGWI-s.........................
A0A6I8NTN6_ORNAN/389-473 .........................p-YYLRSFLMVLQGV...L..E..N...E..D..D....LrlF..DQ.QD..T.DI.IAKF.........Y.Q.LS.G...............NGQRLYVRLFQ.R.K..........L......N...W.I.KT.S.K.I..E...Y..E..E..I.GpD....LS...P.V.I.E...ELKQAGFL-q.........................
A0A7K6QSX0_9PASS/396-480 .........................p-YYLQNFLVVLRTV...L..E..N...E..D..Dv..rL..F..ND.QD..M.NI.VTKF.........Y.K.LS.A...............GGQKLYVRLFQ.R.K..........L......H...W.L.KV.N.K.I..E...Y..G..E..I.S.V...dLS...P.I.I.E...ELAEARFL-q.........................
A0A7L3MJI4_9PASS/392-476 .........................p-YYLQNFLVVLRAV...L..E..N...E..D..Dv..rL..F..NE.QD..L.NI.ITKF.........Y.K.LS.V...............GGQKLYVRLFQ.R.K..........L......N...W.L.KV.N.K.I..E...Y..G..E..I.S.V...dLS...P.I.I.E...ELAEARFL-q.........................
A0A7K4RS43_COLPI/397-481 .........................p-YYLQNFLLVLQAV...L..R..N...E..D..Dv..rL..F..DE.QD..V.NI.ITKF.........C.K.LS.V...............GGQKLYVRLFQ.R.K..........L......N...W.L.KV.N.K.I..E...Y..G..E..I.S.M...dLS...P.I.I.E...ELSEAGFL-q.........................
#=GC seq_cons ...........................aYlpsFthlLcsV...L..c..p...c..s..c....L..F..s-.pE..h.sh.lppF.........p.p.LS.h...............suQtLYVRLFt.R.K..........t......s...W.h.+h.s.+.L..p...Y..s..E..I.u.s....ls...s.s.l.p...-Ltpttal.p.........................
//
