#=GF ID Flavi_NS2B
#=GF AC PF01002.22
#=GF DE Flavivirus non-structural protein NS2B
#=GF AU Finn RD;0000-0001-8626-2148
#=GF AU Bateman A;0000-0002-6982-4660
#=GF SE Pfam-B_156 (release 3.0)
#=GF GA 23.50 23.50;
#=GF TC 23.80 100.40;
#=GF NC 23.30 19.80;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 9499070
#=GF RT Signal peptidase cleavage at the flavivirus C-prM junction:
#=GF RT dependence on the viral NS2B-3 protease for efficient processing
#=GF RT requires determinants in C, the signal peptide, and prM.
#=GF RA Stocks CE, Lobigs M;
#=GF RL J Virol 1998;72:2141-2149.
#=GF RN [2]
#=GF RM 7884844
#=GF RT Formation of the flavivirus envelope: role of the viral NS2B-NS3
#=GF RT protease.
#=GF RA Yamshchikov VF, Compans RW;
#=GF RL J Virol 1995;69:1995-2003.
#=GF DR INTERPRO; IPR000487;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC Flaviviruses encode a single polyprotein. This is cleaved into
#=GF CC three structural and seven non-structural proteins. All, but
#=GF CC two, are cleaved by the NS2B-NS3 protease complex.
#=GF SQ 4
#=GS POLG_YEFV1/1358-1484 AC P03314.1
#=GS POLG_ZIKV/1373-1498 AC Q32ZE1.1
#=GS POLG_ZIKV/1373-1498 DR PDB; 5ZMS D; 50-87;
#=GS POLG_ZIKV/1373-1498 DR PDB; 5ZMQ E; 50-87;
#=GS POLG_ZIKV/1373-1498 DR PDB; 5GPI E; 50-87;
#=GS POLG_ZIKV/1373-1498 DR PDB; 5ZOB G; 50-87;
#=GS POLG_ZIKV/1373-1498 DR PDB; 5GPI A; 50-87;
#=GS POLG_ZIKV/1373-1498 DR PDB; 5YOD E; 50-87;
#=GS POLG_ZIKV/1373-1498 DR PDB; 5GJ4 A; 49-87;
#=GS POLG_ZIKV/1373-1498 DR PDB; 6JPW C; 50-87;
#=GS POLG_ZIKV/1373-1498 DR PDB; 6L4Z G; 50-89;
#=GS POLG_ZIKV/1373-1498 DR PDB; 6KK5 A; 50-87;
#=GS POLG_ZIKV/1373-1498 DR PDB; 5ZOB E; 50-87;
#=GS POLG_ZIKV/1373-1498 DR PDB; 5ZMQ C; 51-87;
#=GS POLG_ZIKV/1373-1498 DR PDB; 5T1V A; 6-22;
#=GS POLG_ZIKV/1373-1498 DR PDB; 6KK3 A; 50-87;
#=GS POLG_ZIKV/1373-1498 DR PDB; 6Y3B A; 50-87;
#=GS POLG_ZIKV/1373-1498 DR PDB; 5ZMS J; 50-87;
#=GS POLG_ZIKV/1373-1498 DR PDB; 6JPW A; 50-87;
#=GS POLG_ZIKV/1373-1498 DR PDB; 5ZOB A; 50-88;
#=GS POLG_ZIKV/1373-1498 DR PDB; 5TFN B; 49-66;
#=GS POLG_ZIKV/1373-1498 DR PDB; 6L50 G; 50-87;
#=GS POLG_ZIKV/1373-1498 DR PDB; 6JPW E; 50-87;
#=GS POLG_ZIKV/1373-1498 DR PDB; 5ZMS A; 50-87;
#=GS POLG_ZIKV/1373-1498 DR PDB; 6KK6 A; 50-87;
#=GS POLG_ZIKV/1373-1498 DR PDB; 5TFN A; 50-69;
#=GS POLG_ZIKV/1373-1498 DR PDB; 5YOD C; 50-87;
#=GS POLG_ZIKV/1373-1498 DR PDB; 5ZMQ A; 50-87;
#=GS POLG_ZIKV/1373-1498 DR PDB; 6L50 E; 51-87;
#=GS POLG_ZIKV/1373-1498 DR PDB; 5YOF A; 50-88;
#=GS POLG_ZIKV/1373-1498 DR PDB; 5TFO A; 50-68;
#=GS POLG_ZIKV/1373-1498 DR PDB; 5GJ4 C; 49-87;
#=GS POLG_ZIKV/1373-1498 DR PDB; 6L4Z A; 50-87;
#=GS POLG_ZIKV/1373-1498 DR PDB; 5TFO B; 49-64;
#=GS POLG_ZIKV/1373-1498 DR PDB; 5YOD A; 50-87;
#=GS POLG_ZIKV/1373-1498 DR PDB; 5GXJ A; 50-68;
#=GS POLG_ZIKV/1373-1498 DR PDB; 6KPQ A; 50-87;
#=GS POLG_ZIKV/1373-1498 DR PDB; 5GPI C; 51-87;
#=GS POLG_ZIKV/1373-1498 DR PDB; 5ZOB C; 50-88;
#=GS POLG_ZIKV/1373-1498 DR PDB; 6L50 A; 50-87;
#=GS POLG_ZIKV/1373-1498 DR PDB; 5ZMS G; 50-87;
#=GS POLG_ZIKV/1373-1498 DR PDB; 5ZMQ G; 50-88;
#=GS POLG_ZIKV/1373-1498 DR PDB; 5GJ4 G; 49-87;
#=GS POLG_ZIKV/1373-1498 DR PDB; 5GPI G; 50-89;
#=GS POLG_ZIKV/1373-1498 DR PDB; 5GXJ B; 48-68;
#=GS POLG_ZIKV/1373-1498 DR PDB; 5GJ4 E; 49-87;
#=GS POLG_ZIKV/1373-1498 DR PDB; 6JPW G; 50-87;
#=GS POLG_ZIKV/1373-1498 DR PDB; 5T1V B; 6-26;
#=GS POLG_ZIKV/1373-1498 DR PDB; 6L4Z E; 50-87;
#=GS POLG_ZIKV/1373-1498 DR PDB; 5YOD G; 50-87;
#=GS POLG_ZIKV/1373-1498 DR PDB; 6KK4 A; 49-87;
#=GS POLG_ZIKV/1373-1498 DR PDB; 6L4Z C; 51-87;
#=GS POLG_ZIKV/1373-1498 DR PDB; 6L50 C; 51-87;
#=GS POLG_ZIKV/1373-1498 DR PDB; 6KK2 A; 50-87;
#=GS POLG_DEN1W/1349-1475 AC P17763.2
#=GS A0A2V1MW33_9LACO/167-293 AC A0A2V1MW33.1
POLG_YEFV1/1358-1484 .VNEALAAAGLVGVLAGLAFQEMENFLGPIAVGGLLMMLVSVAGRVDGLELKKLGEVSWEEEAEISGSSARYDVALSEQGEFKLLSEEKVPWDQVVMTSLALVGAALHPFALLLVLAGWLFHVRGARR
POLG_ZIKV/1373-1498 s--EVLTAVGLICALAGGFAKADIEMAGPMAAVGLLIVSYVVSGKSVDMYIERAGDITWEKDAEVTGNSPRLDVALDESGDFSLVEEDGPPMREIILKVVLMAICGMNPIAIPFAAGAWYVYVKTGKR
#=GR POLG_ZIKV/1373-1498 SS X--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXEEEEEEEEEE----TTSEEESB--EEEEEE-TTS-EEE-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
POLG_DEN1W/1349-1475 .LNEGIMAVGIVSILLSSLLKNDVPLAGPLIAGGMLIACYVISGSSADLSLEKAAEVSWEEEAEHSGASHNILVEVQDDGTMKIKDEERDDTLTILLKATLLAISGVYPMSIPATLFVWYFWQKKKQR
A0A2V1MW33_9LACO/167-293 .LNEAIMAVGMVSILASSLLKNDIPMTGPLVAGGLLTVCYVLTGRSADLELERAADVRWEEQAEISGSSPILSITISEDGSMSIKNEEEEQTLTILIRTGLLVISGLFPVSIPITAAAWYLWEVKKQR
#=GC SS_cons X--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXEEEEEEEEEE----TTSEEESB--EEEEEE-TTS-EEE-XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
#=GC seq_cons .lNEulhAVGlVulLAuuhhKsDlshsGPlsAGGLLhssYVloG+SsDLpLE+Au-VoWEE-AElSGuSsplsVslsEsGshplhsEEcsshhpIll+ssLLsIuGlaPhuIPhshuuWYha.+ptpR
//
