GenomeNet

Database: Pfam
Entry: Frag1
LinkDB: Frag1
Original site: Frag1 
#=GF ID   Frag1
#=GF AC   PF10277.12
#=GF DE   Frag1/DRAM/Sfk1 family
#=GF AU   KOGs;
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF AU   Wood V;0000-0001-6330-7526
#=GF SE   KOGs (KOG3979) & KOGs (KOG4320) & Pfam-B_15139 (release 21.0)
#=GF GA   30.30 30.30;
#=GF TC   30.30 30.30;
#=GF NC   30.20 30.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF CL   CL0412
#=GF RN   [1]
#=GF RM   10585768
#=GF RT   Human FRAG1 encodes a novel membrane-spanning protein that
#=GF RT   localizes to chromosome 11p15.5, a region of frequent loss of
#=GF RT   heterozygosity in cancer. 
#=GF RA   Lorenzi MV, Castagnino P, Aaronson DC, Lieb DC, Lee CC, Keck CL,
#=GF RA   Popescu NC, Miki T; 
#=GF RL   Genomics. 1999;62:59-66.
#=GF RN   [2]
#=GF RM   16839881
#=GF RT   DRAM, a p53-induced modulator of autophagy, is critical for
#=GF RT   apoptosis. 
#=GF RA   Crighton D, Wilkinson S, O'Prey J, Syed N, Smith P, Harrison PR,
#=GF RA   Gasco M, Garrone O, Crook T, Ryan KM; 
#=GF RL   Cell. 2006;126:121-134.
#=GF RN   [3]
#=GF RM   12015967
#=GF RT   Stt4 PI 4-kinase localizes to the plasma membrane and functions
#=GF RT   in the Pkc1-mediated MAP kinase cascade. 
#=GF RA   Audhya A, Emr SD; 
#=GF RL   Dev Cell. 2002;2:593-605.
#=GF DR   INTERPRO; IPR019402;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family includes Frag1, DRAM and Sfk1 proteins.  Frag1 (FGF
#=GF CC   receptor activating protein 1) is a protein that is conserved
#=GF CC   from fungi to humans.  There are four potential iso-prenylation
#=GF CC   sites throughout the peptide, viz CILW, CIIW and CIGL. Frag1 is
#=GF CC   a membrane-spanning protein that is ubiquitously expressed in
#=GF CC   adult tissues suggesting an important cellular function [1]. 
#=GF CC   Dram is a family of proteins conserved from nematodes to humans
#=GF CC   with six hydrophobic transmembrane regions and an Endoplasmic
#=GF CC   Reticulum signal peptide. It is a lysosomal protein that induces
#=GF CC   macro-autophagy as an effector of p53-mediated death, where p53
#=GF CC   is the tumour-suppressor gene that is frequently mutated in
#=GF CC   cancer. Expression of Dram is stress-induced [2].  This region
#=GF CC   is also part of a family of small plasma membrane proteins,
#=GF CC   referred to as Sfk1, that may act together with or upstream of
#=GF CC   Stt4p to generate normal levels of the essential phospholipid
#=GF CC   PI4P, thus allowing proper localisation of Stt4p to the actin
#=GF CC   cytoskeleton [3].
#=GF SQ   5448
#=GS A0A553MMN5_9TELE/3-232      AC A0A553MMN5.1
#=GS E9PKT0_HUMAN/1-81           AC E9PKT0.1
#=GS A0A1S3AQA9_ERIEU/7-226      AC A0A1S3AQA9.1
#=GS A0A6P4I8W3_DROKI/19-240     AC A0A6P4I8W3.1
#=GS A0A1V6PG33_PENDC/15-225     AC A0A1V6PG33.1
#=GS Q4E2S1_TRYCC/9-251          AC Q4E2S1.1
#=GS A0A0F8XC93_9EURO/15-246     AC A0A0F8XC93.1
#=GS A0A6J0X5Y1_ODOVR/4-207      AC A0A6J0X5Y1.1
#=GS W2YKJ2_PHYPR/3-194          AC W2YKJ2.1
#=GS A0A0P1B870_9BASI/17-248     AC A0A0P1B870.1
#=GS A0A0D2WT94_CAPO3/8-212      AC A0A0D2WT94.1
#=GS A0A402EJ06_9SAUR/1-205      AC A0A402EJ06.1
#=GS G9MEI9_HYPVG/1-215          AC G9MEI9.1
#=GS A0A3Q1I6V2_ANATE/19-242     AC A0A3Q1I6V2.1
#=GS A0A6G0HNJ6_LARCR/3-225      AC A0A6G0HNJ6.1
#=GS Q0CFU2_ASPTN/1-205          AC Q0CFU2.1
#=GS A0A0J0XKC3_9TREE/9-275      AC A0A0J0XKC3.1
#=GS A0A091IFF8_CALAN/8-218      AC A0A091IFF8.1
#=GS A0A0L1J695_ASPNO/5-224      AC A0A0L1J695.1
#=GS A0A670HPC9_PODMU/13-181     AC A0A670HPC9.1
#=GS A0A4Z2DLD2_SCHJA/9-188      AC A0A4Z2DLD2.1
#=GS K5W1X3_PHACS/18-227         AC K5W1X3.1
#=GS A0A2Y9QCE5_DELLE/8-218      AC A0A2Y9QCE5.1
#=GS A0A550CZY4_9AGAR/15-228     AC A0A550CZY4.1
#=GS K3WME5_GLOUD/181-430        AC K3WME5.1
#=GS W3XFB0_PESFW/18-228         AC W3XFB0.1
#=GS A0A6P6XVH8_DERPT/56-302     AC A0A6P6XVH8.1
#=GS A0A668RCV0_OREAU/3-232      AC A0A668RCV0.1
#=GS A0A7E4RMR1_CIMLE/1-214      AC A0A7E4RMR1.1
#=GS A0A663ESQ9_AQUCH/1-209      AC A0A663ESQ9.1
#=GS A0A3Q2WXI8_HAPBU/7-226      AC A0A3Q2WXI8.1
#=GS A0A7F8Q2U2_LEPWE/1-150      AC A0A7F8Q2U2.1
#=GS A0A161HHX6_9ASCO/6-223      AC A0A161HHX6.1
#=GS A0A6J3DWZ0_AYTFU/18-237     AC A0A6J3DWZ0.1
#=GS A0A5F8GIA9_MONDO/108-213    AC A0A5F8GIA9.1
#=GS A0A2G9RGL2_LITCT/10-146     AC A0A2G9RGL2.1
#=GS A0A5B1QEE9_9AGAM/12-222     AC A0A5B1QEE9.1
#=GS G3AIS7_SPAPN/23-233         AC G3AIS7.1
#=GS A0A226DI32_FOLCA/8-243      AC A0A226DI32.1
#=GS A0A6P7Y265_9AMPH/6-214      AC A0A6P7Y265.1
#=GS A0A1V8TVF1_9PEZI/15-225     AC A0A1V8TVF1.1
#=GS A8NUC4_COPC7/75-210         AC A8NUC4.2
#=GS A0A1L8H1L9_XENLA/3-232      AC A0A1L8H1L9.1
#=GS A0A1B8EHK4_9PEZI/5-221      AC A0A1B8EHK4.1
#=GS A0A0B1T065_OESDE/5-146      AC A0A0B1T065.1
#=GS G7NAJ0_MACMU/3-232          AC G7NAJ0.1
#=GS A0A2K5HWF0_COLAP/8-207      AC A0A2K5HWF0.1
#=GS A0A6P8GCZ3_CLUHA/3-227      AC A0A6P8GCZ3.1
#=GS T150B_MOUSE/4-207           AC Q8R218.1
#=GS A0A3Q7Y6Y8_URSAR/18-245     AC A0A3Q7Y6Y8.1
#=GS A0A2T0FGH7_9ASCO/6-222      AC A0A2T0FGH7.1
#=GS G0NQG0_CAEBE/45-283         AC G0NQG0.1
#=GS A0A024US62_9STRA/24-232     AC A0A024US62.1
#=GS A0A084VJE6_ANOSI/9-227      AC A0A084VJE6.1
#=GS A0A063BX62_USTVR/16-226     AC A0A063BX62.1
#=GS A0A667WVC3_9TELE/7-234      AC A0A667WVC3.1
#=GS A0A5N5KDS1_PANHP/3-232      AC A0A5N5KDS1.1
#=GS A0A6J1TAN2_FRAOC/22-248     AC A0A6J1TAN2.1
#=GS A0A0L7RDU3_9HYME/35-256     AC A0A0L7RDU3.1
#=GS K1WMT7_MARBU/5-221          AC K1WMT7.1
#=GS A0A074WEE0_9PEZI/6-223      AC A0A074WEE0.1
#=GS A0A7E6E166_9CHIR/18-208     AC A0A7E6E166.1
#=GS A0A3B3IIV0_ORYLA/3-232      AC A0A3B3IIV0.1
#=GS A0A1Y1W487_9FUNG/2-221      AC A0A1Y1W487.1
#=GS A0A093C1H5_9AVES/85-193     AC A0A093C1H5.1
#=GS A0A067BCD7_SAPPC/1-194      AC A0A067BCD7.1
#=GS A0A5N5DEN0_9PEZI/14-224     AC A0A5N5DEN0.1
#=GS A0A5N6FM94_PETAA/5-224      AC A0A5N6FM94.1
#=GS A0A1S3CUF4_DIACI/2-186      AC A0A1S3CUF4.2
#=GS A0A3B1IY83_ASTMX/7-234      AC A0A3B1IY83.1
#=GS A0A673XMH7_SALTR/18-240     AC A0A673XMH7.1
#=GS A0A1V9ZM35_9STRA/46-262     AC A0A1V9ZM35.1
#=GS A8MZF5_HUMAN/1-85           AC A8MZF5.4
#=GS G2QG59_MYCTT/18-228         AC G2QG59.1
#=GS A0A3Q2ZQI2_KRYMA/3-224      AC A0A3Q2ZQI2.1
#=GS A0A1Y2ET55_9BASI/6-235      AC A0A1Y2ET55.1
#=GS A0A3Q2L0E3_HORSE/3-232      AC A0A3Q2L0E3.1
#=GS A0A166QMU8_9PEZI/17-227     AC A0A166QMU8.1
#=GS Q3V5H7_CAEEL/24-251         AC Q3V5H7.1
#=GS A0A0C2N6G9_THEKT/54-237     AC A0A0C2N6G9.1
#=GS A0A2G8JDB0_STIJA/3-168      AC A0A2G8JDB0.1
#=GS E0VJN5_PEDHC/1-234          AC E0VJN5.1
#=GS A0A226PXA5_COLVI/62-206     AC A0A226PXA5.1
#=GS R4G9G4_ANOCA/12-222         AC R4G9G4.1
#=GS B7QH05_IXOSC/16-242         AC B7QH05.1
#=GS A0A6I9PM68_9TELE/3-93       AC A0A6I9PM68.1
#=GS A0A1X7VN59_AMPQE/1-151      AC A0A1X7VN59.1
#=GS A0A674B2K0_SALTR/115-336    AC A0A674B2K0.1
#=GS A0A672V0K8_STRHB/18-241     AC A0A672V0K8.1
#=GS A0A6J1W0F5_9SAUR/48-276     AC A0A6J1W0F5.1
#=GS A0A3Q3WG01_MOLML/6-213      AC A0A3Q3WG01.1
#=GS A0A3B3H7N4_ORYLA/4-161      AC A0A3B3H7N4.1
#=GS A0A2A2LNY0_9BILA/14-144     AC A0A2A2LNY0.1
#=GS A0A316W416_9BASI/7-235      AC A0A316W416.1
#=GS A0A4Z1HXZ9_9HELO/6-236      AC A0A4Z1HXZ9.1
#=GS A0A3Q1JN84_ANATE/7-234      AC A0A3Q1JN84.1
#=GS A0A395MZ66_9HYPO/17-227     AC A0A395MZ66.1
#=GS A0A0D2H8M5_9EURO/14-224     AC A0A0D2H8M5.1
#=GS A0A0L0N5C5_TOLOC/17-227     AC A0A0L0N5C5.1
#=GS A0A672K8Y4_SINGR/7-121      AC A0A672K8Y4.1
#=GS A0A2Y9RB63_TRIMA/58-284     AC A0A2Y9RB63.1
#=GS B3MM60_DROAN/19-240         AC B3MM60.1
#=GS A0A2N5VYQ4_9BASI/11-227     AC A0A2N5VYQ4.1
#=GS A0A212DEZ0_CEREH/1-118      AC A0A212DEZ0.1
#=GS A0A5E4BKC9_MARMO/3-95       AC A0A5E4BKC9.1
#=GS E9QCN7_DANRE/6-216          AC E9QCN7.1
#=GS G3NYV4_GASAC/3-232          AC G3NYV4.1
#=GS A0A6J0BRF4_NEOLC/27-247     AC A0A6J0BRF4.1
#=GS A0A6A4X3F1_AMPAM/102-325    AC A0A6A4X3F1.1
#=GS A0A674C952_SALTR/7-234      AC A0A674C952.1
#=GS G5BU84_HETGA/3-232          AC G5BU84.1
#=GS A0A2K6ECV2_MACNE/7-226      AC A0A2K6ECV2.1
#=GS A0A3Q0KBX9_SCHMA/1-215      AC A0A3Q0KBX9.1
#=GS V9EMW0_PHYPR/3-283          AC V9EMW0.1
#=GS A0A5K4FD31_SCHMA/7-231      AC A0A5K4FD31.1
#=GS F7BPL7_CALJA/74-297         AC F7BPL7.2
#=GS R8BU71_TOGMI/5-222          AC R8BU71.1
#=GS A0A0D2EDG9_9EURO/78-307     AC A0A0D2EDG9.1
#=GS A0A0C4DWT3_MAGP6/18-228     AC A0A0C4DWT3.1
#=GS A0A397I7N2_9EURO/1-209      AC A0A397I7N2.1
#=GS A0A4W6CX75_LATCA/6-217      AC A0A4W6CX75.1
#=GS H2U8L6_TAKRU/3-134          AC H2U8L6.2
#=GS I3JYU8_ORENI/3-232          AC I3JYU8.1
#=GS F1S630_PIG/7-233            AC F1S630.1
#=GS A0A6P8RJH3_GEOSA/18-241     AC A0A6P8RJH3.1
#=GS A0A6P7N5P0_BETSP/3-203      AC A0A6P7N5P0.1
#=GS A0A668SPM6_OREAU/3-204      AC A0A668SPM6.1
#=GS A0A1L8H9T8_XENLA/1-166      AC A0A1L8H9T8.1
#=GS H2MFH1_ORYLA/19-241         AC H2MFH1.1
#=GS A0A1E3HAT5_9TREE/107-238    AC A0A1E3HAT5.1
#=GS A0A6L2Q318_COPFO/10-215     AC A0A6L2Q318.1
#=GS A0A5C6N7U7_9TELE/7-234      AC A0A5C6N7U7.1
#=GS A0A4W5K7S2_9TELE/7-234      AC A0A4W5K7S2.1
#=GS A0A2K5D2C2_AOTNA/7-120      AC A0A2K5D2C2.1
#=GS A0A667Z635_9TELE/7-227      AC A0A667Z635.1
#=GS A0A165CDF4_9APHY/11-224     AC A0A165CDF4.1
#=GS A0A177SXN6_9BASI/1-124      AC A0A177SXN6.1
#=GS A0A0A1T525_9HYPO/18-228     AC A0A0A1T525.1
#=GS SFK1_SCHPO/21-232           AC Q9Y7U1.1
#=GS A0A5E4CDT0_MARMO/204-268    AC A0A5E4CDT0.1
#=GS A0A091MSG6_APAVI/8-219      AC A0A091MSG6.1
#=GS A0A1N7Q3A5_9GAMM/3-212      AC A0A1N7Q3A5.1
#=GS A0A4W5LVM3_9TELE/3-204      AC A0A4W5LVM3.1
#=GS A0A6P3FR58_OCTDE/3-232      AC A0A6P3FR58.1
#=GS A0A3Q1LRH2_BOVIN/58-243     AC A0A3Q1LRH2.1
#=GS A0A1B8AMV1_FUSPO/17-227     AC A0A1B8AMV1.1
#=GS A0A4W6E6T3_LATCA/3-136      AC A0A4W6E6T3.1
#=GS A0A6P7P595_BETSP/6-217      AC A0A6P7P595.1
#=GS A0A3N4M8W9_9PEZI/14-223     AC A0A3N4M8W9.1
#=GS A0A5Q4BCL6_9PEZI/17-227     AC A0A5Q4BCL6.1
#=GS A0A1L8FNJ1_XENLA/3-204      AC A0A1L8FNJ1.1
#=GS A0A4W6CX74_LATCA/23-236     AC A0A4W6CX74.1
#=GS A0A5B0QG28_PUCGR/11-227     AC A0A5B0QG28.1
#=GS A0A1J9QQS8_9EURO/15-225     AC A0A1J9QQS8.1
#=GS A0A2I3GZ91_NOMLE/18-241     AC A0A2I3GZ91.1
#=GS A0A6I9K9K9_CHRAS/18-237     AC A0A6I9K9K9.1
#=GS A0A7F8RV53_LEPWE/32-242     AC A0A7F8RV53.1
#=GS A0A6P6Y1M5_DERPT/5-231      AC A0A6P6Y1M5.1
#=GS A0A2K6KCS2_RHIBE/1-182      AC A0A2K6KCS2.1
#=GS F7WAA4_SORMK/18-228         AC F7WAA4.1
#=GS A0A2Y9HTI4_NEOSC/3-232      AC A0A2Y9HTI4.1
#=GS A0A135S2Q5_9PEZI/17-227     AC A0A135S2Q5.1
#=GS A0A0N4YET3_NIPBR/41-266     AC A0A0N4YET3.1
#=GS R0L454_ANAPL/7-233          AC R0L454.1
#=GS A0A2K5M9I0_CERAT/18-241     AC A0A2K5M9I0.1
#=GS A7RTD1_NEMVE/1-228          AC A7RTD1.1
#=GS A0A165IC79_XYLHT/5-221      AC A0A165IC79.1
#=GS A0A226EYG8_FOLCA/47-268     AC A0A226EYG8.1
#=GS A0A5N5WR05_9EURO/28-276     AC A0A5N5WR05.1
#=GS A0A6J0XHJ5_ODOVR/8-218      AC A0A6J0XHJ5.1
#=GS A0A063BT76_USTVR/8-225      AC A0A063BT76.1
#=GS A0A179I3K7_CORDF/8-95       AC A0A179I3K7.1
#=GS A0A667WSW9_9TELE/6-219      AC A0A667WSW9.1
#=GS A0A1V9XS74_9ACAR/10-231     AC A0A1V9XS74.1
#=GS A0A1B9FW11_9TREE/8-275      AC A0A1B9FW11.1
#=GS A0A6J2UYH7_CHACN/3-233      AC A0A6J2UYH7.1
#=GS A0A0D2BFH0_9EURO/5-221      AC A0A0D2BFH0.1
#=GS W9X3S2_9EURO/1-183          AC W9X3S2.1
#=GS A0A668RXQ8_OREAU/6-217      AC A0A668RXQ8.1
#=GS A0A4U0VRS9_9BASI/11-226     AC A0A4U0VRS9.1
#=GS A0A1Y2X733_9PEZI/1-215      AC A0A1Y2X733.1
#=GS A0A2K5RCR4_CEBIM/7-226      AC A0A2K5RCR4.1
#=GS A0A4Z2CZD0_SCHJA/7-231      AC A0A4Z2CZD0.1
#=GS A0A2U3ZAN6_ODORO/18-241     AC A0A2U3ZAN6.1
#=GS A0A2K6LTA5_RHIBE/18-228     AC A0A2K6LTA5.1
#=GS A0A0D8XAV2_DICVI/3-159      AC A0A0D8XAV2.1
#=GS A0A194Q6H7_PAPXU/41-266     AC A0A194Q6H7.1
#=GS M2QXS3_CERS8/1-130          AC M2QXS3.1
#=GS A0A1A6H8L9_NEOLE/98-317     AC A0A1A6H8L9.1
#=GS A0A0J8RVC5_COCIT/12-207     AC A0A0J8RVC5.1
#=GS A0A1X7RYR9_ZYMTR/5-222      AC A0A1X7RYR9.1
#=GS A0A0D1Y7E6_EXOME/14-224     AC A0A0D1Y7E6.1
#=GS A0A226NIP7_CALSU/7-176      AC A0A226NIP7.1
#=GS A0A091GWL5_BUCRH/1-67       AC A0A091GWL5.1
#=GS A0A425BRZ8_9PEZI/3-164      AC A0A425BRZ8.1
#=GS A0A6P4YSK9_BRABE/15-238     AC A0A6P4YSK9.1
#=GS A0A4Y9ZBU6_9AGAM/12-222     AC A0A4Y9ZBU6.1
#=GS S9XYA1_CAMFR/89-155         AC S9XYA1.1
#=GS G4VJ18_SCHMA/6-228          AC G4VJ18.1
#=GS A0A2I3LHS8_PAPAN/31-179     AC A0A2I3LHS8.1
#=GS A0A0C7N9T6_9SACH/5-205      AC A0A0C7N9T6.1
#=GS A0A6P8Z0F7_THRPL/24-245     AC A0A6P8Z0F7.1
#=GS A0A484BZ78_PERFV/7-226      AC A0A484BZ78.1
#=GS A0A672H281_SALFA/63-285     AC A0A672H281.1
#=GS A0A2Y9R5G4_TRIMA/1-176      AC A0A2Y9R5G4.1
#=GS A0A669BTA6_ORENI/3-204      AC A0A669BTA6.1
#=GS R7YTR9_CONA1/15-225         AC R7YTR9.1
#=GS A0A5F9CYZ6_RABIT/19-242     AC A0A5F9CYZ6.1
#=GS A0A6J3L335_9HYME/5-231      AC A0A6J3L335.1
#=GS A0A4P9X8Y6_9FUNG/19-250     AC A0A4P9X8Y6.1
#=GS A0A1U7TZM7_CARSF/1-141      AC A0A1U7TZM7.1
#=GS A0A674HPK1_TAEGU/11-221     AC A0A674HPK1.1
#=GS A0A1S8AB15_ROSNE/17-243     AC A0A1S8AB15.1
#=GS A0A3P6SIC0_LITSI/8-260      AC A0A3P6SIC0.1
#=GS T1G8D8_HELRO/28-249         AC T1G8D8.1
#=GS A0A452ECM4_CAPHI/8-218      AC A0A452ECM4.1
#=GS E3QB38_COLGM/5-222          AC E3QB38.1
#=GS I3ITX5_ORENI/7-226          AC I3ITX5.2
#=GS O77262_DROME/3-230          AC O77262.1
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A0A484DFX2_PERFV/470-697               ...............................................................................gl--CFLPAALV.V.W.TAA...SFVF.A.......Y...I...T.A..VS..LR..HV.D.PL..---..----.............................................VP..Y..I......SD...T.......GT..M.A.P.E.RC......V..FG......IML.D.VSA...........F........L...........G...I.A.T....V....YV....R...YKQ...............................................................................................................................................................VE..A..L.T..G..E.GEFKl.........................................nrLNRFG.LLLG.LI.....SS...F.....G.M....C.V..VANF.....................................Q...K.T..TL..........F.....S.......M.......HL.V.GAV..LT.....FGVGAL.Y.IVV.Q.T....L.L..S...L.H..M..QPH-............................................................................................................--.VHS.RT.I..Y.LV..R...L...S..L..G...L..W..T..M..S....S..I....I....S......M.....F.....V.SS.VI.M...Y..S..SLpgvdvphk...........................................lhwtpgetGYTAHI..I..S....TVS..EWSLA....FSF.I.S.FF..LTY.IRDFQK-i........................................................................................................................
A0A0W7VID2_9HYPO/8-225                 ................................................................................s-YWILPVISS.L.V.WCG...MLLG.L.......L...L...Y.W..VV..DT.nSE.H.YS..YMD..KGDN.............................................IA..F..I......SD...I.......GA..S.K.L.K.PL......F..IA......GSS.V.TTA...........F........L...........D...L.S.F....A....AE....R...LLRhn...........................................................................................................................................................grLV..P..N.T..T..G.KEKV............................................FSILS.IIFA.IV.....GT...C.....G.L....I.L..LSIF.....................................D...T.H..HH..........H.....R.......A.......HD.V.FLL..LF.....IAGYII.S.AIF.I.C....A.E..Y...Y.V..L..GLYN...........................................................................................................rHH.KVL.RI.S..F.WV..K...I...A..F..V...I..V..E..F..V....F..A....V....V......F.....V.....A.TN.WS.N...N..E..--...........................................................-----N..V..A....AVF..EWIIA....FIF.T.F.YI..LSF.VIDL---lpa......................................................................................................................
A0A2L2TF26_9HYPO/17-227                ...............................................................................ng--SLVSWAHT.T.V.AYT...AFFS.A.......L...V...I.G..LC..LH..YH.K.IV..QNE.fYGYPq..........................................ewFP..S..V......SA..tI.......GD..R.Y.P.E.RS......F..FM......IFI.A.ITS...........G........P...........R...F.A.L....V....GL....W...YLL...............................................................................................................................................................TR..K..P.G..Q..K.----............................................LPTFV.AVMG.LV.....RT...L.....T.C....G.G..WTYI.....................................T...S.T..DD..........H.....D.......W.......HD.I.LMI..SY.....IVATLP.W.TTG.C.I....A.L..S...-.-..-..----............................................................................................................--.PAN.PQ.A..I.KY..R...K...Y..L..A...S..A..F..F..G....T..L....V....P......L.....I.....Y.FF.IQ.H...K..V..HR...........................................................VAGAYT..T..Y....AFF..EWSLI....IFD.V.A.FD..AVT.ALDFST-f........................................................................................................................
A0A6J8D3G1_MYTCO/28-253                ................................................................................g-LSYLPILLV.L.T.SFA...TFIV.S.......Y...I...I.A..IV..RH..DV.S.PY..---..----.............................................FP..Y..I......SD...T.......GT..K.P.P.E.SC......I..FG......QFL.N.ISA...........A........L...........A...I.A.T....M....YV....R...YKL...............................................................................................................................................................VS..Q..I.S..V..G.EDTKl.........................................acLNKAG.LVLG.IL.....SA...L.....G.L....S.M..VANF.....................................Q...E.T..NV..........E.....P.......V.......HV.T.GAA..LV.....LGVGVI.Y.AFV.Q.T....S.L..S...Y.R..M..NPDY............................................................................................................--.-NG.LK.I..C.RI..R...L...A..I..S...C..I..A..L..T....A..M....I....I......T.....F.....V.SA.TV.S...R..I..QVhghidkt.............................................kwkpedgGFTAHI..I..S....TIS..EWVTA....VTF.L.L.FF..FTF.VRDFQK-v........................................................................................................................
A0A165QK09_EXIGL/41-256                .................................................................................WYIWIPLFTA.F.I.WFS...TLLA.M.......L...I...T.W..LA..QG..RQ.F.YV..SES..PGQK.............................................VA..Y..I......SD...V.......GA..D.I.L.K.PL......F..IV......GCS.I.TAV...........G........F...........F...L.T.L....C....VE....R...WLRhs...........................................................................................................................................................grLH..P..N.M..R..R.RERV............................................CSSIA.MFGS.FI.....GG...A.....A.L....I.L..LSVF.....................................D...T.K..RH..........M.....T.......L.......HR.V.FLF..FF.....VLGVAV.S.AIF.T.V....L.E..F...R.W..I..EKSY...........................................................................................................pDA.THL.RR.A..Y.ML..K...G...F..L..A...V..V..L..I..A....A..A....I....A......F.....G.....V.TL.GR.K...-..-..--...........................................................----QN..V..A....AII..EWCIS....FGF.T.F.YL..LTF.YADLR--as.......................................................................................................................
A0A364LBS5_9EURO/351-623               ................................................................................g----------.-.-.-FA...MLGA.L.......L...G...S.W..FT..SG..QP.R.YI..SEE..DTQT.............................................IA..F..I......SD...I.......GA..Q.H.L.K.PV......F..IA......CTS.I.AMI...........T........Y...........I...P.S.L....I....FY....F...YHMsparrplssssesiirvnslp.....................................................................................................................siystpppsslasrhhlhqepK-..-..-.-..-..-.---Whqsp...................................vfqmsIPVLS.ILFS.VI.....GA...T.....N.L....I.L..LTIF.....................................D...T.A..RY..........T.....S.......A.......HQ.I.LLP..TS.....ISAHLL.G.CLI.L.C....I.W..T...T.F..C..LHQYrsqqhnhkysygggg..............................................................................giysgdkftlelytpPI.PIS.LS.S..L.VV..K...F...V..V..V...A..I..E..F..S....L..V....T....L......F.....A.....V.MT.WW.L...K..T..--...........................................................----YD..E..A....AVM..EWVVV....LMF.A.G.YM..LCL.IVDLW--vl.......................................................................................................................
V9EFF1_PHYPR/3-194                     .........................................................................alpedatv----------.-.-.---...----.-.......-...-...-.-..--..--..--.-.--..---..----.............................................--..-..-......--...-.......--..-.-.-.-.--......-..--......---.-.---...........-........-...........-...-.-.-....-....--....-...---...............................................................................................................................................................--..-..-.-..-..-.-YRV............................................LSTIS.WIAG.VL.....AN...P.....G.L....P.V..LAFF.....................................D...T.S..KH..........S.....K.....