GenomeNet

Database: Pfam
Entry: GGDEF
LinkDB: GGDEF
Original site: GGDEF 
#=GF ID   GGDEF
#=GF AC   PF00990.22
#=GF DE   Diguanylate cyclase, GGDEF domain
#=GF PI   DUF9; 
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   Pfam-B_112 (release 3.0)
#=GF GA   23.80 23.80;
#=GF TC   23.80 23.80;
#=GF NC   23.70 23.70;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF WK   GGDEF_domain
#=GF RN   [1]
#=GF RM   11119645
#=GF RT   GGDEF domain is homologous to adenylyl cyclase. 
#=GF RA   Pei J, Grishin NV; 
#=GF RL   Proteins 2001;42:210-216.
#=GF RN   [2]
#=GF RM   11557134
#=GF RT   Novel domains of the prokaryotic two-component signal
#=GF RT   transduction systems. 
#=GF RA   Galperin MY, Nikolskaya AN, Koonin EV; 
#=GF RL   FEMS Microbiol Lett 2001;203:11-21.
#=GF RN   [3]
#=GF RM   15063857
#=GF RT   Cyclic di-guanosine-monophosphate comes of age: a novel
#=GF RT   secondary messenger involved in modulating cell surface
#=GF RT   structures in bacteria?. 
#=GF RA   Jenal U; 
#=GF RL   Curr Opin Microbiol 2004;7:185-191.
#=GF RN   [4]
#=GF RM   15075296
#=GF RT   Cell cycle-dependent dynamic localization of a bacterial
#=GF RT   response regulator with a novel di-guanylate cyclase output
#=GF RT   domain. 
#=GF RA   Paul R, Weiser S, Amiot NC, Chan C, Schirmer T, Giese B, Jenal
#=GF RA   U; 
#=GF RL   Genes Dev 2004;18:715-727.
#=GF RN   [5]
#=GF RM   15142243
#=GF RT   Bacterial signal transduction network in a genomic perspective. 
#=GF RA   Galperin MY; 
#=GF RL   Environ Microbiol 2004;6:552-567.
#=GF RN   [6]
#=GF RM   15569936
#=GF RT   Structural basis of activity and allosteric control of
#=GF RT   diguanylate cyclase. 
#=GF RA   Chan C, Paul R, Samoray D, Amiot NC, Giese B, Jenal U, Schirmer
#=GF RA   T; 
#=GF RL   Proc Natl Acad Sci U S A 2004;101:17084-17089.
#=GF RN   [7]
#=GF RM   16923812
#=GF RT   Allosteric control of cyclic di-GMP signaling.
#=GF RA   Christen B, Christen M, Paul R, Schmid F, Folcher M, Jenoe P,
#=GF RA   Meuwly M, Jenal U;
#=GF RL   J Biol Chem. 2006;281:32015-32024.
#=GF RN   [8]
#=GF RM   18366254
#=GF RT   Phosphorylation-independent regulation of the diguanylate
#=GF RT   cyclase WspR.
#=GF RA   De N, Pirruccello M, Krasteva PV, Bae N, Raghavan RV, Sondermann
#=GF RA   H;
#=GF RL   PLoS Biol. 2008;6:e67.
#=GF RN   [9]
#=GF RM   21757706
#=GF RT   The atypical two-component sensor kinase Lpl0330 from Legionella
#=GF RT   pneumophila controls the bifunctional diguanylate
#=GF RT   cyclase-phosphodiesterase Lpl0329 to modulate bis-(3'-5')-cyclic
#=GF RT   dimeric GMP synthesis.
#=GF RA   Levet-Paulo M, Lazzaroni JC, Gilbert C, Atlan D, Doublet P,
#=GF RA   Vianney A;
#=GF RL   J Biol Chem. 2011;286:31136-31144.
#=GF DR   INTERPRO; IPR000160;
#=GF DR   SCOP; 1w25; fa;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This domain is found linked to a wide range of non-homologous
#=GF CC   domains in a variety of bacteria. It has been shown to be
#=GF CC   homologous to the adenylyl cyclase catalytic domain [1] and has
#=GF CC   diguanylate cyclase activity [4]. This observation correlates
#=GF CC   with the functional information available on two
#=GF CC   GGDEF-containing proteins, namely diguanylate cyclase and
#=GF CC   phosphodiesterase A of Acetobacter xylinum, both of which
#=GF CC   regulate the turnover of cyclic diguanosine monophosphate. In
#=GF CC   the WspR protein of Pseudomonas aeruginosa, the GGDEF domain
#=GF CC   acts as a diguanylate cyclase, PDB:3bre, when the whole molecule
#=GF CC   appears to form a tetramer consisting of two
#=GF CC   symmetrically-related dimers representing a biological unit. The
#=GF CC   active site is the GGD/EF motif, buried in the structure, and
#=GF CC   the cyclic dimeric guanosine monophosphate (c-di-GMP) bind to
#=GF CC   the inhibitory-motif RxxD on the surface. The enzyme thus
#=GF CC   catalyses the cyclisation of two guanosine triphosphate (GTP)
#=GF CC   molecules to one c-di-GMP molecule [6,7,8].
#=GF SQ   80352
#=GS V4RT17_9CAUL/180-338          AC V4RT17.1
#=GS A0A0Q5QXC5_9SPHN/179-331      AC A0A0Q5QXC5.1
#=GS A0A097EKD4_9SPHN/175-331      AC A0A097EKD4.1
#=GS A0A0E3Z554_9GAMM/457-616      AC A0A0E3Z554.1
#=GS A0A1I3LK04_9BURK/194-355      AC A0A1I3LK04.1
#=GS Q0IA05_SYNS3/154-300          AC Q0IA05.1
#=GS A0A1I2W8B0_9GAMM/353-509      AC A0A1I2W8B0.1
#=GS A0A2N7QW57_9GAMM/199-362      AC A0A2N7QW57.1
#=GS F9USE8_LACPL/214-374          AC F9USE8.1
#=GS A0A2D2M2W2_9PSED/430-586      AC A0A2D2M2W2.1
#=GS A6W6S8_KINRD/21-174           AC A6W6S8.1
#=GS A0A1H3ZSE8_9GAMM/134-291      AC A0A1H3ZSE8.1
#=GS H0J5Q9_9GAMM/565-727          AC H0J5Q9.1
#=GS A0A2T5MGE0_9GAMM/188-345      AC A0A2T5MGE0.1
#=GS A0A147K873_9BACI/196-353      AC A0A147K873.1
#=GS A0A0K6GVM5_9NEIS/359-512      AC A0A0K6GVM5.1
#=GS A0A1N6PTK8_9BRAD/561-720      AC A0A1N6PTK8.1
#=GS DGCC_ECOLI/210-366            AC P0AAP1.1
#=GS A0A261GI29_9GAMM/39-193       AC A0A261GI29.1
#=GS A0A1U9NGA2_9GAMM/412-568      AC A0A1U9NGA2.1
#=GS A0A0Q6VLQ7_9BURK/136-292      AC A0A0Q6VLQ7.1
#=GS A0A0Q3KF15_9BRAD/179-338      AC A0A0Q3KF15.1
#=GS K6YXF5_9ALTE/78-237           AC K6YXF5.1
#=GS A0A1B3LJS2_9PROT/477-641      AC A0A1B3LJS2.1
#=GS A0A240TZ53_9BURK/136-293      AC A0A240TZ53.1
#=GS A0A1D8RUD1_9GAMM/263-420      AC A0A1D8RUD1.1
#=GS J3CEM5_9RHIZ/292-455          AC J3CEM5.1
#=GS A0A385NSD2_9BACI/400-565      AC A0A385NSD2.1
#=GS A0A0S3PU67_9BRAD/272-427      AC A0A0S3PU67.1
#=GS A0A077LKF0_9PSED/219-375      AC A0A077LKF0.1
#=GS T2GCB1_DESGG/470-628          AC T2GCB1.1
#=GS A0A1I7HDR2_9FIRM/831-984      AC A0A1I7HDR2.1
#=GS S6C0Z4_9GAMM/202-280          AC S6C0Z4.1
#=GS A0A1X7MR80_9LACT/353-511      AC A0A1X7MR80.1
#=GS A0A385YQV3_9BACL/340-493      AC A0A385YQV3.1
#=GS A0A395YKB9_9CLOT/249-399      AC A0A395YKB9.1
#=GS A0A0F3KHV6_9NEIS/215-376      AC A0A0F3KHV6.1
#=GS A0A1D9NZE6_9FIRM/129-281      AC A0A1D9NZE6.1
#=GS Q6N5F7_RHOPA/208-363          AC Q6N5F7.1
#=GS F0RLS7_DEIPM/384-538          AC F0RLS7.1
#=GS A0A1H8QCC8_9PSEU/302-465      AC A0A1H8QCC8.1
#=GS D6SSR7_9DELT/259-416          AC D6SSR7.1
#=GS A0A0Q7JLX8_9ACTN/182-326      AC A0A0Q7JLX8.1
#=GS A0A417CDA4_9FIRM/545-702      AC A0A417CDA4.1
#=GS A0A1M7ZIL6_9RHIZ/335-491      AC A0A1M7ZIL6.1
#=GS A0A1I6Y7F4_9FIRM/248-401      AC A0A1I6Y7F4.1
#=GS A0A073AWP1_9PSEU/138-283      AC A0A073AWP1.1
#=GS A0A386DYV0_9RHIZ/145-301      AC A0A386DYV0.1
#=GS A0A1H9LDA2_9BACT/219-375      AC A0A1H9LDA2.1
#=GS A0A2S8YQ26_9PSED/473-629      AC A0A2S8YQ26.1
#=GS Q21GT7_SACD2/183-339          AC Q21GT7.1
#=GS A0A2A3GZL2_9ACTN/606-768      AC A0A2A3GZL2.1
#=GS V4TG47_9RHIZ/176-335          AC V4TG47.1
#=GS A0A165R810_9SPHN/394-550      AC A0A165R810.1
#=GS A0A0A2UTQ5_9BACI/471-619      AC A0A0A2UTQ5.1
#=GS A4JNT0_BURVG/342-498          AC A4JNT0.1
#=GS U2ZA34_PSEA4/470-624          AC U2ZA34.1
#=GS A0A2R4XGL2_9BORD/500-665      AC A0A2R4XGL2.1
#=GS K2JX46_9GAMM/189-345          AC K2JX46.1
#=GS A0A1C5G7G0_9ACTN/39-181       AC A0A1C5G7G0.1
#=GS A0A085VM80_PSESX/533-689      AC A0A085VM80.1
#=GS A0A437M344_9PROT/395-551      AC A0A437M344.1
#=GS J2FZ97_9SPHN/272-433          AC J2FZ97.1
#=GS A0A1T4RZ90_9GAMM/12-168       AC A0A1T4RZ90.1
#=GS A0A3N7K184_9BURK/672-829      AC A0A3N7K184.1
#=GS A0A1I1MKI8_9CLOT/636-792      AC A0A1I1MKI8.1
#=GS A0A1H6DG51_9GAMM/359-515      AC A0A1H6DG51.1
#=GS A0A1A8T3J4_9GAMM/440-597      AC A0A1A8T3J4.1
#=GS Q8ZLP2_SALTY/224-381          AC Q8ZLP2.1
#=GS A0A233RGG1_9GAMM/136-293      AC A0A233RGG1.1
#=GS J1H0L3_9CLOT/222-377          AC J1H0L3.1
#=GS A0A1H4CPM6_9DELT/344-503      AC A0A1H4CPM6.1
#=GS A0A494YSU8_9BACI/161-313      AC A0A494YSU8.1
#=GS A0A1H3BM22_9ALTE/146-302      AC A0A1H3BM22.1
#=GS A0A0D2GEV5_9DELT/225-385      AC A0A0D2GEV5.1
#=GS A0A074N2S8_9SPHN/55-207       AC A0A074N2S8.1
#=GS S6H649_9GAMM/238-395          AC S6H649.1
#=GS A0A1H0HXH0_9BURK/51-210       AC A0A1H0HXH0.1
#=GS A0A1H9F994_9BACT/459-624      AC A0A1H9F994.1
#=GS A0A1Y0D0H4_9GAMM/321-482      AC A0A1Y0D0H4.1
#=GS A0A1L6JGR2_9SPHN/177-329      AC A0A1L6JGR2.1
#=GS B9L5Q2_NAUPA/303-456          AC B9L5Q2.1
#=GS A0A495DB55_9ALTE/382-540      AC A0A495DB55.1
#=GS A0A261GM88_9GAMM/419-584      AC A0A261GM88.1
#=GS A0A0X3TIQ8_9GAMM/138-299      AC A0A0X3TIQ8.1
#=GS A0A098UCB9_9BURK/152-320      AC A0A098UCB9.1
#=GS D2U8W8_XANAP/218-369          AC D2U8W8.1
#=GS A0A1N7SJA5_9BURK/306-464      AC A0A1N7SJA5.1
#=GS A0A091APG5_9GAMM/142-298      AC A0A091APG5.1
#=GS A0A1B3PPW6_9BURK/513-681      AC A0A1B3PPW6.1
#=GS D0I367_GRIHO/603-760          AC D0I367.1
#=GS R6QY19_9CLOT/555-711          AC R6QY19.1
#=GS K8DZW4_9FIRM/383-545          AC K8DZW4.1
#=GS A0A366ZGM7_9ACTN/380-534      AC A0A366ZGM7.1
#=GS A0A2U1CBJ9_9BURK/198-354      AC A0A2U1CBJ9.1
#=GS A0A323UTK4_9RHOO/146-303      AC A0A323UTK4.1
#=GS A0A254TH71_9BURK/709-874      AC A0A254TH71.1
#=GS H2FX39_OCESG/392-552          AC H2FX39.1
#=GS A0A1I4QDS2_9PSED/275-431      AC A0A1I4QDS2.1
#=GS A0A395YF81_9CLOT/520-668      AC A0A395YF81.1
#=GS A0A1I5LJZ5_9FIRM/463-619      AC A0A1I5LJZ5.1
#=GS A0A0W0XQ83_9GAMM/151-309      AC A0A0W0XQ83.1
#=GS A8V4T8_9AQUI/1-80             AC A8V4T8.1
#=GS A0A0M7A000_9RHOB/149-314      AC A0A0M7A000.1
#=GS A0A1V3N813_9GAMM/186-349      AC A0A1V3N813.1
#=GS A0A2K8L047_9GAMM/141-295      AC A0A2K8L047.1
#=GS W8KUB5_9GAMM/412-571          AC W8KUB5.1
#=GS A0A1I6KXV5_9GAMM/405-562      AC A0A1I6KXV5.1
#=GS A0A1M5VJQ8_9VIBR/87-225       AC A0A1M5VJQ8.1
#=GS A0A0R2F9G2_9LACO/203-364      AC A0A0R2F9G2.1
#=GS A0A2K4G9V0_9PSED/128-285      AC A0A2K4G9V0.1
#=GS V6EYF3_MAGGM/341-497          AC V6EYF3.1
#=GS A0A1E5QQF3_9CYAN/141-312      AC A0A1E5QQF3.1
#=GS A0A1H0A795_9DELT/87-245       AC A0A1H0A795.1
#=GS J1E8K7_9BURK/181-323          AC J1E8K7.1
#=GS A0A0Q6W4B7_9BURK/813-974      AC A0A0Q6W4B7.1
#=GS A0A346NKB1_9ALTE/464-622      AC A0A346NKB1.1
#=GS A0A090R9K7_9VIBR/563-717      AC A0A090R9K7.1
#=GS A0A0W0Z7C9_LEGSP/321-478      AC A0A0W0Z7C9.1
#=GS A0A3R9X6J0_9SPHN/339-496      AC A0A3R9X6J0.1
#=GS A0A427CAU5_9GAMM/365-515      AC A0A427CAU5.1
#=GS A0A260WHV2_9NOCA/307-455      AC A0A260WHV2.1
#=GS J2L808_9BURK/405-566          AC J2L808.1
#=GS A0A2I8DFG5_9BURK/263-420      AC A0A2I8DFG5.1
#=GS A0A0F4PRY1_9GAMM/168-309      AC A0A0F4PRY1.1
#=GS A0A1I2FF20_9ACTN/363-520      AC A0A1I2FF20.1
#=GS A0A1H5WRN4_9RHOO/381-538      AC A0A1H5WRN4.1
#=GS W7Q0B9_9GAMM/350-507          AC W7Q0B9.1
#=GS R4LSU1_9ACTN/468-618          AC R4LSU1.1
#=GS A0A0K8P4I2_IDESA/313-470      AC A0A0K8P4I2.1
#=GS A0A2Z4UL81_9RHIZ/264-421      AC A0A2Z4UL81.1
#=GS A0A3P1SS55_9GAMM/582-739      AC A0A3P1SS55.1
#=GS E6W5R6_DESIS/383-539          AC E6W5R6.1
#=GS A0A0L6TZY7_9FIRM/435-592      AC A0A0L6TZY7.1
#=GS M5EI39_9RHIZ/89-242           AC M5EI39.1
#=GS A0A0Q6MK03_9BURK/452-616      AC A0A0Q6MK03.1
#=GS A0A2S9GSJ4_9BURK/279-441      AC A0A2S9GSJ4.1
#=GS A0A1H8BDS0_9FIRM/1-122        AC A0A1H8BDS0.1
#=GS A0A254TAA3_9BURK/50-207       AC A0A254TAA3.1
#=GS B4VXK2_9CYAN/417-584          AC B4VXK2.1
#=GS S0G2R7_9DELT/360-524          AC S0G2R7.1
#=GS A0A1G9MJQ0_9PSED/250-407      AC A0A1G9MJQ0.1
#=GS Q3AFS2_CARHZ/379-536          AC Q3AFS2.1
#=GS A0A087B943_9BIFI/241-383      AC A0A087B943.1
#=GS A0A1Y6ISI9_9VIBR/304-460      AC A0A1Y6ISI9.1
#=GS A0A1C3RJZ6_9RHIZ/262-417      AC A0A1C3RJZ6.1
#=GS A0A2N7X9Z4_9BURK/341-501      AC A0A2N7X9Z4.1
#=GS A0A1I3GBG9_9RHOB/191-349      AC A0A1I3GBG9.1
#=GS A0A2A4AP60_9PSED/250-407      AC A0A2A4AP60.1
#=GS A0A267MK51_9CLOT/379-535      AC A0A267MK51.1
#=GS S6BAZ3_9GAMM/165-331          AC S6BAZ3.1
#=GS A0A1M5KG95_9BACT/227-377      AC A0A1M5KG95.1
#=GS A0A0Q6C6X6_9RHIZ/121-276      AC A0A0Q6C6X6.1
#=GS H5V589_ATLHE/237-391          AC H5V589.1
#=GS A0A1H6XSU8_9DEIO/186-341      AC A0A1H6XSU8.1
#=GS A5G6K7_GEOUR/189-346          AC A5G6K7.1
#=GS D5V0B5_ARCNC/253-409          AC D5V0B5.1
#=GS D3RML3_ALLVD/270-428          AC D3RML3.1
#=GS A0A1B7UMK4_9GAMM/85-242       AC A0A1B7UMK4.1
#=GS A0A1T5FKQ0_9FIRM/200-353      AC A0A1T5FKQ0.1
#=GS B5IMB7_9CYAN/107-263          AC B5IMB7.1
#=GS A0A0Q7SVP4_9BURK/146-311      AC A0A0Q7SVP4.1
#=GS A0A285E7M3_9ACTN/451-608      AC A0A285E7M3.1
#=GS H6RTL6_BLASD/1-119            AC H6RTL6.1
#=GS G2FDS2_9GAMM/150-307          AC G2FDS2.1
#=GS A0A1I1NF20_9GAMM/1030-1201    AC A0A1I1NF20.1
#=GS A6TC40_KLEP7/324-447          AC A6TC40.1
#=GS A0A3D8IBD5_9HELI/206-363      AC A0A3D8IBD5.1
#=GS Q92KK4_RHIME/338-503          AC Q92KK4.1
#=GS A0A3A5GBF4_9DELT/449-594      AC A0A3A5GBF4.1
#=GS A0A0T1WGS4_9MYCO/342-495      AC A0A0T1WGS4.1
#=GS Q8X9C7_ECO57/224-381          AC Q8X9C7.1
#=GS E0UUH5_SULAO/448-600          AC E0UUH5.1
#=GS B3PF81_CELJU/137-294          AC B3PF81.1
#=GS A0A2I2KFM6_9PROT/229-388      AC A0A2I2KFM6.1
#=GS A0A090V0U1_ESCVU/397-556      AC A0A090V0U1.1
#=GS A0A077LBC0_9PSED/115-270      AC A0A077LBC0.1
#=GS A0A0C4WL67_9GAMM/202-359      AC A0A0C4WL67.1
#=GS M2U340_9SPHN/172-323          AC M2U340.1
#=GS A0A0A3HU07_9BACI/257-404      AC A0A0A3HU07.1
#=GS Q5R165_IDILO/131-285          AC Q5R165.1
#=GS A0A372JUA1_9ACTN/258-415      AC A0A372JUA1.1
#=GS A0A1W1VSW3_9DEIO/5-147        AC A0A1W1VSW3.1
#=GS A0A143QCK7_9NOCA/187-339      AC A0A143QCK7.1
#=GS A0A1V1NZG1_9DELT/106-154      AC A0A1V1NZG1.1
#=GS U4K529_9VIBR/279-439          AC U4K529.1
#=GS A0A2S4M7M6_9BURK/86-236       AC A0A2S4M7M6.1
#=GS A0A1H6D8P6_9GAMM/203-366      AC A0A1H6D8P6.1
#=GS Q5E0N3_ALIF1/293-436          AC Q5E0N3.1
#=GS A0A0G3F084_9BURK/175-336      AC A0A0G3F084.1
#=GS A0A1R4HYM3_9MICO/176-320      AC A0A1R4HYM3.1
#=GS A0A1Y0I1V4_9GAMM/116-261      AC A0A1Y0I1V4.1
#=GS Q211N5_RHOPB/231-389          AC Q211N5.1
#=GS A0A1I0QWE6_9FIRM/175-333      AC A0A1I0QWE6.1
#=GS A0A286EIA7_9ACTN/258-416      AC A0A286EIA7.1
#=GS G2IYT3_PSEUL/550-712          AC G2IYT3.1
#=GS A0A2S6IF98_9ACTN/313-465      AC A0A2S6IF98.1
#=GS A0A1Y2K3A1_9PROT/257-412      AC A0A1Y2K3A1.1
#=GS W1SES7_9SPHN/122-285          AC W1SES7.1
#=GS A0A160DY98_9GAMM/391-548      AC A0A160DY98.1
#=GS A0A073CQR0_PLAAG/166-323      AC A0A073CQR0.1
#=GS A0A101JAQ6_9ACTN/308-465      AC A0A101JAQ6.1
#=GS A0A1V4IMX0_9CLOT/119-274      AC A0A1V4IMX0.1
#=GS A0A1T4JXW8_9FIRM/184-334      AC A0A1T4JXW8.1
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