GenomeNet

Database: Pfam
Entry: GGDEF
LinkDB: GGDEF
Original site: GGDEF 
#=GF ID   GGDEF
#=GF AC   PF00990.21
#=GF DE   Diguanylate cyclase, GGDEF domain
#=GF PI   DUF9; 
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   Pfam-B_112 (release 3.0)
#=GF GA   22.20 22.20;
#=GF TC   22.20 22.20;
#=GF NC   22.10 22.10;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 45638612 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF WK   GGDEF_domain
#=GF RN   [1]
#=GF RM   11119645
#=GF RT   GGDEF domain is homologous to adenylyl cyclase. 
#=GF RA   Pei J, Grishin NV; 
#=GF RL   Proteins 2001;42:210-216.
#=GF RN   [2]
#=GF RM   11557134
#=GF RT   Novel domains of the prokaryotic two-component signal
#=GF RT   transduction systems. 
#=GF RA   Galperin MY, Nikolskaya AN, Koonin EV; 
#=GF RL   FEMS Microbiol Lett 2001;203:11-21.
#=GF RN   [3]
#=GF RM   15063857
#=GF RT   Cyclic di-guanosine-monophosphate comes of age: a novel
#=GF RT   secondary messenger involved in modulating cell surface
#=GF RT   structures in bacteria?. 
#=GF RA   Jenal U; 
#=GF RL   Curr Opin Microbiol 2004;7:185-191.
#=GF RN   [4]
#=GF RM   15075296
#=GF RT   Cell cycle-dependent dynamic localization of a bacterial
#=GF RT   response regulator with a novel di-guanylate cyclase output
#=GF RT   domain. 
#=GF RA   Paul R, Weiser S, Amiot NC, Chan C, Schirmer T, Giese B, Jenal
#=GF RA   U; 
#=GF RL   Genes Dev 2004;18:715-727.
#=GF RN   [5]
#=GF RM   15142243
#=GF RT   Bacterial signal transduction network in a genomic perspective. 
#=GF RA   Galperin MY; 
#=GF RL   Environ Microbiol 2004;6:552-567.
#=GF RN   [6]
#=GF RM   15569936
#=GF RT   Structural basis of activity and allosteric control of
#=GF RT   diguanylate cyclase. 
#=GF RA   Chan C, Paul R, Samoray D, Amiot NC, Giese B, Jenal U, Schirmer
#=GF RA   T; 
#=GF RL   Proc Natl Acad Sci U S A 2004;101:17084-17089.
#=GF RN   [7]
#=GF RM   16923812
#=GF RT   Allosteric control of cyclic di-GMP signaling.
#=GF RA   Christen B, Christen M, Paul R, Schmid F, Folcher M, Jenoe P,
#=GF RA   Meuwly M, Jenal U;
#=GF RL   J Biol Chem. 2006;281:32015-32024.
#=GF RN   [8]
#=GF RM   18366254
#=GF RT   Phosphorylation-independent regulation of the diguanylate
#=GF RT   cyclase WspR.
#=GF RA   De N, Pirruccello M, Krasteva PV, Bae N, Raghavan RV, Sondermann
#=GF RA   H;
#=GF RL   PLoS Biol. 2008;6:e67.
#=GF RN   [9]
#=GF RM   21757706
#=GF RT   The atypical two-component sensor kinase Lpl0330 from Legionella
#=GF RT   pneumophila controls the bifunctional diguanylate
#=GF RT   cyclase-phosphodiesterase Lpl0329 to modulate bis-(3'-5')-cyclic
#=GF RT   dimeric GMP synthesis.
#=GF RA   Levet-Paulo M, Lazzaroni JC, Gilbert C, Atlan D, Doublet P,
#=GF RA   Vianney A;
#=GF RL   J Biol Chem. 2011;286:31136-31144.
#=GF DR   INTERPRO; IPR000160;
#=GF DR   SCOP; 1w25; fa;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This domain is found linked to a wide range of non-homologous
#=GF CC   domains in a variety of bacteria. It has been shown to be
#=GF CC   homologous to the adenylyl cyclase catalytic domain [1] and has
#=GF CC   diguanylate cyclase activity [4]. This observation correlates
#=GF CC   with the functional information available on two
#=GF CC   GGDEF-containing proteins, namely diguanylate cyclase and
#=GF CC   phosphodiesterase A of Acetobacter xylinum, both of which
#=GF CC   regulate the turnover of cyclic diguanosine monophosphate. In
#=GF CC   the WspR protein of Pseudomonas aeruginosa, the GGDEF domain
#=GF CC   acts as a diguanylate cyclase, PDB:3bre, when the whole molecule
#=GF CC   appears to form a tetramer consisting of two
#=GF CC   symmetrically-related dimers representing a biological unit. The
#=GF CC   active site is the GGD/EF motif, buried in the structure, and
#=GF CC   the cyclic dimeric guanosine monophosphate (c-di-GMP) bind to
#=GF CC   the inhibitory-motif RxxD on the surface. The enzyme thus
#=GF CC   catalyses the cyclisation of two guanosine triphosphate (GTP)
#=GF CC   molecules to one c-di-GMP molecule [6,7,8].
#=GF SQ   85410
#=GS A0A090K1B6_9GAMM/548-701    AC A0A090K1B6.1
#=GS C9KL06_9FIRM/1397-1541      AC C9KL06.1
#=GS A0A1M6VFY1_9FIRM/162-320    AC A0A1M6VFY1.1
#=GS V4RT17_9CAUL/180-338        AC V4RT17.1
#=GS A0A0Q5QXC5_9SPHN/179-331    AC A0A0Q5QXC5.1
#=GS A0A097EKD4_9SPHN/175-331    AC A0A097EKD4.1
#=GS A0A0E3Z554_9GAMM/457-616    AC A0A0E3Z554.1
#=GS A0A1I3LK04_9BURK/194-355    AC A0A1I3LK04.1
#=GS A0A1G1IR65_9BACT/17-173     AC A0A1G1IR65.1
#=GS Q0IA05_SYNS3/154-300        AC Q0IA05.1
#=GS A0A1I2W8B0_9GAMM/353-509    AC A0A1I2W8B0.1
#=GS F9USE8_LACPL/214-374        AC F9USE8.1
#=GS K2QWX4_9RHIZ/303-457        AC K2QWX4.1
#=GS A6W6S8_KINRD/21-174         AC A6W6S8.1
#=GS H0J5Q9_9GAMM/565-727        AC H0J5Q9.1
#=GS A0A147K873_9BACI/196-353    AC A0A147K873.1
#=GS A0A1N6PTK8_9BRAD/561-720    AC A0A1N6PTK8.1
#=GS DGCC_ECOLI/210-366          AC P0AAP1.1
#=GS A0A261GI29_9GAMM/39-193     AC A0A261GI29.1
#=GS A0A1U9NGA2_9GAMM/412-568    AC A0A1U9NGA2.1
#=GS A0A0Q6VLQ7_9BURK/136-292    AC A0A0Q6VLQ7.1
#=GS A0A0Q3KF15_9BRAD/179-338    AC A0A0Q3KF15.1
#=GS A0A0A1B4X3_9GAMM/404-561    AC A0A0A1B4X3.1
#=GS K6YXF5_9ALTE/78-237         AC K6YXF5.1
#=GS A0A1B3LJS2_9PROT/477-641    AC A0A1B3LJS2.1
#=GS A0A240TZ53_9BURK/136-293    AC A0A240TZ53.1
#=GS A0A1D8RUD1_9GAMM/263-420    AC A0A1D8RUD1.1
#=GS J3CEM5_9RHIZ/292-455        AC J3CEM5.1
#=GS A0A077LKF0_9PSED/219-375    AC A0A077LKF0.1
#=GS T2GCB1_DESGI/470-628        AC T2GCB1.1
#=GS A0A1I7HDR2_9FIRM/831-984    AC A0A1I7HDR2.1
#=GS S6C0Z4_9GAMM/202-280        AC S6C0Z4.1
#=GS A0A1X7MR80_9LACT/353-511    AC A0A1X7MR80.1
#=GS A0A0F3KHV6_9NEIS/215-376    AC A0A0F3KHV6.1
#=GS A0A1D9NZE6_9FIRM/129-281    AC A0A1D9NZE6.1
#=GS A0A177QH77_9BACT/161-319    AC A0A177QH77.1
#=GS Q6N5F7_RHOPA/208-363        AC Q6N5F7.1
#=GS F0RLS7_DEIPM/384-538        AC F0RLS7.1
#=GS A0A1H8QCC8_9PSEU/302-465    AC A0A1H8QCC8.1
#=GS D6SSR7_9DELT/259-416        AC D6SSR7.1
#=GS A0A074MP23_9SPHN/155-312    AC A0A074MP23.1
#=GS A0A0Q7JLX8_9ACTN/182-326    AC A0A0Q7JLX8.1
#=GS A0A258NS99_9BURK/284-446    AC A0A258NS99.1
#=GS A0A0X3Y681_9GAMM/557-714    AC A0A0X3Y681.1
#=GS A0A1T5AAF1_9GAMM/472-629    AC A0A1T5AAF1.1
#=GS A0A1M7ZIL6_9RHIZ/335-491    AC A0A1M7ZIL6.1
#=GS A0A117S9X8_9FIRM/368-507    AC A0A117S9X8.1
#=GS A0A1I6Y7F4_9FIRM/248-401    AC A0A1I6Y7F4.1
#=GS A0A073AWP1_9PSEU/138-283    AC A0A073AWP1.1
#=GS A0A1S8Y773_9ENTR/136-294    AC A0A1S8Y773.1
#=GS A0A260BTX3_9NOCA/157-314    AC A0A260BTX3.1
#=GS A0A1H9LDA2_9BACT/219-375    AC A0A1H9LDA2.1
#=GS Q21GT7_SACD2/183-339        AC Q21GT7.1
#=GS A0A1Y5ESF1_9GAMM/558-715    AC A0A1Y5ESF1.1
#=GS A0A2A3GZL2_9ACTN/606-768    AC A0A2A3GZL2.1
#=GS V4TG47_9RHIZ/176-335        AC V4TG47.1
#=GS A0A165R810_9SPHN/394-550    AC A0A165R810.1
#=GS I3IC27_9GAMM/332-485        AC I3IC27.1
#=GS A0A0A2UTQ5_9BACI/471-619    AC A0A0A2UTQ5.1
#=GS A4JNT0_BURVG/342-498        AC A4JNT0.1
#=GS U2ZA34_PSEA4/470-624        AC U2ZA34.1
#=GS K2JX46_9GAMM/189-345        AC K2JX46.1
#=GS A0A094IEK0_9BACT/397-544    AC A0A094IEK0.1
#=GS A0A1C5G7G0_9ACTN/39-181     AC A0A1C5G7G0.1
#=GS A0A0Q4RP13_9BURK/779-936    AC A0A0Q4RP13.1
#=GS A0A245ZKK2_9SPHN/405-550    AC A0A245ZKK2.1
#=GS A0A085VM80_PSESX/533-689    AC A0A085VM80.1
#=GS J2FZ97_9SPHN/272-433        AC J2FZ97.1
#=GS A0A1T4RZ90_9GAMM/12-168     AC A0A1T4RZ90.1
#=GS A0A1I1MKI8_9CLOT/636-792    AC A0A1I1MKI8.1
#=GS A0A256FUE0_9RHIZ/134-295    AC A0A256FUE0.1
#=GS A0A1A8T3J4_9GAMM/440-597    AC A0A1A8T3J4.1
#=GS R7HWR2_9CLOT/60-216         AC R7HWR2.1
#=GS Q8ZLP2_SALTY/224-381        AC Q8ZLP2.1
#=GS L0LY46_RHITR/149-302        AC L0LY46.1
#=GS J1H0L3_9CLOT/222-377        AC J1H0L3.1
#=GS A0A1H4CPM6_9DELT/344-503    AC A0A1H4CPM6.1
#=GS A0A1H3BM22_9ALTE/146-302    AC A0A1H3BM22.1
#=GS A0A0D2GEV5_9DELT/225-385    AC A0A0D2GEV5.1
#=GS A0A074N2S8_9SPHN/55-207     AC A0A074N2S8.1
#=GS A0A1R1C989_9BACL/366-530    AC A0A1R1C989.1
#=GS S6H649_9GAMM/238-395        AC S6H649.1
#=GS A0A0Q6REL0_9RHIZ/176-334    AC A0A0Q6REL0.1
#=GS A0A258FDW8_9CAUL/370-515    AC A0A258FDW8.1
#=GS A0A1H0HXH0_9BURK/51-210     AC A0A1H0HXH0.1
#=GS A0A1H9F994_9BACT/459-624    AC A0A1H9F994.1
#=GS A0A1L6JGR2_9SPHN/177-329    AC A0A1L6JGR2.1
#=GS B9L5Q2_NAUPA/303-456        AC B9L5Q2.1
#=GS A0A261GM88_9GAMM/419-584    AC A0A261GM88.1
#=GS A0A0X3TIQ8_9GAMM/138-299    AC A0A0X3TIQ8.1
#=GS A0A098UCB9_9BURK/152-320    AC A0A098UCB9.1
#=GS D2U8W8_XANAP/218-369        AC D2U8W8.1
#=GS A0A1N7SJA5_9BURK/306-464    AC A0A1N7SJA5.1
#=GS H0BW93_9BURK/123-279        AC H0BW93.1
#=GS A0A0F4NLX1_9VIBR/151-312    AC A0A0F4NLX1.1
#=GS A0A241R0M4_9GAMM/479-636    AC A0A241R0M4.1
#=GS A0A091APG5_9GAMM/142-298    AC A0A091APG5.1
#=GS A0A1B3PPW6_9BURK/513-681    AC A0A1B3PPW6.1
#=GS D0I367_GRIHO/603-760        AC D0I367.1
#=GS A0A1W9L7W0_9GAMM/268-436    AC A0A1W9L7W0.1
#=GS R6QY19_9CLOT/555-711        AC R6QY19.1
#=GS K8DZW4_9FIRM/383-545        AC K8DZW4.1
#=GS A0A0E9M526_9PROT/918-1075   AC A0A0E9M526.1
#=GS A0A1F8PHH4_9CHLR/128-242    AC A0A1F8PHH4.1
#=GS A0A176HGY5_9SPHN/219-375    AC A0A176HGY5.1
#=GS A0A254TH71_9BURK/709-874    AC A0A254TH71.1
#=GS A0A0M8Y8I7_9PSEU/324-482    AC A0A0M8Y8I7.1
#=GS H2FX39_OCESG/392-552        AC H2FX39.1
#=GS A0A1W9PIC0_9HELI/361-523    AC A0A1W9PIC0.1
#=GS A0A1I4QDS2_9PSED/275-431    AC A0A1I4QDS2.1
#=GS A0A062UKH7_9RHOB/84-238     AC A0A062UKH7.1
#=GS A0A1I5LJZ5_9FIRM/463-619    AC A0A1I5LJZ5.1
#=GS A0A0W0XQ83_9GAMM/151-309    AC A0A0W0XQ83.1
#=GS H9UBK8_FERPD/1148-1302      AC H9UBK8.1
#=GS A8V4T8_9AQUI/1-80           AC A8V4T8.1
#=GS A0A1H0AUG9_9GAMM/512-666    AC A0A1H0AUG9.1
#=GS A0A254PXJ0_9BURK/270-441    AC A0A254PXJ0.1
#=GS A0A0S8C9B1_9PROT/360-517    AC A0A0S8C9B1.1
#=GS A0A0N0VJ20_9PSED/276-432    AC A0A0N0VJ20.1
#=GS A0A1G9LTY9_9ACTN/408-560    AC A0A1G9LTY9.1
#=GS A0A1V3N813_9GAMM/186-349    AC A0A1V3N813.1
#=GS W8KUB5_HALHR/412-571        AC W8KUB5.1
#=GS A0A1I6KXV5_9GAMM/405-562    AC A0A1I6KXV5.1
#=GS A0A1M5VJQ8_9VIBR/87-225     AC A0A1M5VJQ8.1
#=GS A0A1G1P3Q0_9BACT/131-250    AC A0A1G1P3Q0.1
#=GS A0A0R2F9G2_9LACO/203-364    AC A0A0R2F9G2.1
#=GS A0A1C3WRC3_9RHIZ/322-479    AC A0A1C3WRC3.1
#=GS A0A0R0A328_STEMA/23-165     AC A0A0R0A328.1
#=GS V6EYF3_9PROT/341-497        AC V6EYF3.1
#=GS A0A1E5QQF3_9CYAN/141-312    AC A0A1E5QQF3.1
#=GS A0A1H0A795_9DELT/87-245     AC A0A1H0A795.1
#=GS J1E8K7_9BURK/181-323        AC J1E8K7.1
#=GS A0A0Q6W4B7_9BURK/813-974    AC A0A0Q6W4B7.1
#=GS A0A090R9K7_9VIBR/563-717    AC A0A090R9K7.1
#=GS A0A0W0Z7C9_LEGSP/321-478    AC A0A0W0Z7C9.1
#=GS A0A0Q0HPE2_9GAMM/278-435    AC A0A0Q0HPE2.1
#=GS A0A1E7RMQ3_9GAMM/21-164     AC A0A1E7RMQ3.1
#=GS A0A260WHV2_9NOCA/307-455    AC A0A260WHV2.1
#=GS J2L808_9BURK/405-566        AC J2L808.1
#=GS L8MQ35_PSEPS/298-455        AC L8MQ35.1
#=GS A0A0F4PRY1_9GAMM/168-309    AC A0A0F4PRY1.1
#=GS A0A1I2FF20_9ACTN/363-520    AC A0A1I2FF20.1
#=GS A0A1H5WRN4_9RHOO/381-538    AC A0A1H5WRN4.1
#=GS W7Q0B9_9GAMM/350-507        AC W7Q0B9.1
#=GS A0A1Y3NXJ0_9PSED/469-623    AC A0A1Y3NXJ0.1
#=GS R4LSU1_9ACTN/468-618        AC R4LSU1.1
#=GS A0A0K8P4I2_IDESA/313-470    AC A0A0K8P4I2.1
#=GS A0A120GDC0_9SPHN/139-296    AC A0A120GDC0.1
#=GS A0A257H5V7_9BURK/255-411    AC A0A257H5V7.1
#=GS E6W5R6_DESIS/383-539        AC E6W5R6.1
#=GS A0A0L6TZY7_9FIRM/435-592    AC A0A0L6TZY7.1
#=GS M5EI39_9RHIZ/89-242         AC M5EI39.1
#=GS A0A1G1NBJ3_9BACT/169-326    AC A0A1G1NBJ3.1
#=GS A0A0Q4Q438_9SPHN/217-360    AC A0A0Q4Q438.1
#=GS A0A0E9M9S6_9PROT/523-680    AC A0A0E9M9S6.1
#=GS A0A0Q6MK03_9BURK/452-616    AC A0A0Q6MK03.1
#=GS A0A077F5L5_9PSED/661-823    AC A0A077F5L5.1
#=GS A0A254TAA3_9BURK/50-207     AC A0A254TAA3.1
#=GS B4VXK2_9CYAN/417-584        AC B4VXK2.1
#=GS S0G2R7_9DELT/360-524        AC S0G2R7.1
#=GS A0A1G9MJQ0_9PSED/250-407    AC A0A1G9MJQ0.1
#=GS Q3AFS2_CARHZ/379-536        AC Q3AFS2.1
#=GS A0A1Y6ISI9_9VIBR/304-460    AC A0A1Y6ISI9.1
#=GS H2IB99_VIBSJ/427-577        AC H2IB99.1
#=GS A0A1C3RJZ6_9RHIZ/262-417    AC A0A1C3RJZ6.1
#=GS A0A1I3GBG9_9RHOB/191-349    AC A0A1I3GBG9.1
#=GS A0A267MK51_9CLOT/379-535    AC A0A267MK51.1
#=GS S6BAZ3_9GAMM/165-331        AC S6BAZ3.1
#=GS A0A1M5KG95_9BACT/227-377    AC A0A1M5KG95.1
#=GS A0A0Q6C6X6_9RHIZ/121-276    AC A0A0Q6C6X6.1
#=GS H5V589_ATLHE/237-391        AC H5V589.1
#=GS A0A1H6XSU8_9DEIO/186-341    AC A0A1H6XSU8.1
#=GS A5G6K7_GEOUR/189-346        AC A5G6K7.1
#=GS D5V0B5_ARCNC/253-409        AC D5V0B5.1
#=GS D3RML3_ALLVD/270-428        AC D3RML3.1
#=GS A0A1B7UMK4_9GAMM/85-242     AC A0A1B7UMK4.1
#=GS A0A1T5FKQ0_9FIRM/200-353    AC A0A1T5FKQ0.1
#=GS B5IMB7_9CYAN/107-263        AC B5IMB7.1
#=GS A0A0Q7SVP4_9BURK/146-311    AC A0A0Q7SVP4.1
#=GS A0A2A7N845_9MYCO/312-469    AC A0A2A7N845.1
#=GS A0A285E7M3_9ACTN/451-608    AC A0A285E7M3.1
#=GS H6RTL6_BLASD/1-119          AC H6RTL6.1
#=GS G2FDS2_9GAMM/150-307        AC G2FDS2.1
#=GS A0A1I1NF20_9GAMM/1030-1201  AC A0A1I1NF20.1
#=GS A0A151JJX7_9VIBR/508-654    AC A0A151JJX7.1
#=GS A6TC40_KLEP7/324-447        AC A6TC40.1
#=GS Q92KK4_RHIME/338-503        AC Q92KK4.1
#=GS A0A0T1WGS4_9MYCO/342-495    AC A0A0T1WGS4.1
#=GS Q8X9C7_ECO57/224-381        AC Q8X9C7.1
#=GS E0UUH5_SULAO/448-600        AC E0UUH5.1
#=GS A0A0A0SBN7_9VIBR/206-363    AC A0A0A0SBN7.1
#=GS B3PF81_CELJU/137-294        AC B3PF81.1
#=GS A0A0Q5E702_9RHIZ/300-454    AC A0A0Q5E702.1
#=GS A0A090V0U1_ESCVU/397-556    AC A0A090V0U1.1
#=GS A0A077LBC0_9PSED/115-270    AC A0A077LBC0.1
#=GS A0A0C4WL67_9GAMM/202-359    AC A0A0C4WL67.1
#=GS A0A1F4HUR0_9BURK/346-502    AC A0A1F4HUR0.1
#=GS A0A2D8R9E2_9GAMM/168-324    AC A0A2D8R9E2.1
#=GS M2U340_9SPHN/172-323        AC M2U340.1
#=GS A0A0A3HU07_9BACI/257-404    AC A0A0A3HU07.1
#=GS Q5R165_IDILO/131-285        AC Q5R165.1
#=GS A0A1W1VSW3_9DEIO/5-147      AC A0A1W1VSW3.1
#=GS A0A143QCK7_9NOCA/187-339    AC A0A143QCK7.1
#=GS A0A1V1NZG1_9DELT/106-154    AC A0A1V1NZG1.1
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#=GS D3CRQ4_9ACTN/349-506        AC D3CRQ4.1
#=GS N6V649_9RHIZ/215-372        AC N6V649.1
#=GS A0A1G7TII2_9PROT/178-337    AC A0A1G7TII2.1
#=GS C4XTI2_DESMR/254-410        AC C4XTI2.1
#=GS E0RXB9_BUTPB/405-557        AC E0RXB9.1
#=GS A0A0G0IBF8_9BACT/51-211     AC A0A0G0IBF8.1
#=GS E3CZ52_9BACT/483-640        AC E3CZ52.1
#=GS R9NDD9_9FIRM/135-287        AC R9NDD9.1
#=GS A0A1S1TWN8_9RHIZ/228-382    AC A0A1S1TWN8.1
#=GS A0A0S7BUX3_9CHLR/540-692    AC A0A0S7BUX3.1
#=GS E3CZV3_9BACT/521-678        AC E3CZV3.1
#=GS A0A258TVJ0_9PROT/341-488    AC A0A258TVJ0.1
#=GS A0A059FPZ4_9RHOB/99-252     AC A0A059FPZ4.1
#=GS A0A0J6D276_9BACI/381-536    AC A0A0J6D276.1
#=GS A0A0A0BM02_9CELL/323-482    AC A0A0A0BM02.1
#=GS H0IZL2_9GAMM/151-304        AC H0IZL2.1
#=GS A0A095X1M1_9GAMM/234-324    AC A0A095X1M1.1
#=GS A0A1Q3RR11_9FIRM/348-507    AC A0A1Q3RR11.1
#=GS A9WCL4_CHLAA/414-570        AC A9WCL4.1
#=GS A0A1Z9YC14_9RHOB/264-421    AC A0A1Z9YC14.1
#=GS Q89GW4_BRADU/266-427        AC Q89GW4.1
#=GS A0A2D8RCX1_9GAMM/192-348    AC A0A2D8RCX1.1
#=GS Q9Z568_STRCO/611-778        AC Q9Z568.1
#=GS A0A239FXF2_9PSED/219-375    AC A0A239FXF2.1
#=GS V4PG84_9CAUL/180-338        AC V4PG84.1
#=GS A0A0J8GWA2_9ALTE/542-697    AC A0A0J8GWA2.1
#=GS A0A0Q5I9T5_9BURK/213-369    AC A0A0Q5I9T5.1
#=GS G1UQ43_9DELT/371-519        AC G1UQ43.1
#=GS C1CZN9_DEIDV/8-147          AC C1CZN9.1
#=GS L0KDK0_HALHC/190-340        AC L0KDK0.1
#=GS A0A1G8X4D0_9MICO/384-540    AC A0A1G8X4D0.1
#=GS B3PFT6_CELJU/134-292        AC B3PFT6.1
#=GS A0A1G7VAS5_9PSED/448-605    AC A0A1G7VAS5.1
#=GS V9R723_9PSED/124-277        AC V9R723.1
#=GS A8ZW17_DESOH/236-392        AC A8ZW17.1
#=GS W4VMS3_9BACI/2-57           AC W4VMS3.1
#=GS G2HS14_9PROT/399-523        AC G2HS14.1
#=GS I4WHJ7_9GAMM/430-591        AC I4WHJ7.1
#=GS A0A077F7X5_9PSED/204-352    AC A0A077F7X5.1
#=GS A0A1A8Y2D4_9RHOO/555-726    AC A0A1A8Y2D4.1
#=GS A0A0K9XA73_9ACTN/287-444    AC A0A0K9XA73.1
#=GS Q9HUN5_PSEAE/496-653        AC Q9HUN5.1
#=GS A0A1G6Z837_9PROT/415-573    AC A0A1G6Z837.1
#=GS A0A1G3UHD0_9HELI/133-287    AC A0A1G3UHD0.1
#=GS E8N331_ANATU/449-606        AC E8N331.1
#=GS A0A1I5H3N3_9SPHN/114-270    AC A0A1I5H3N3.1
#=GS A0A0F5PVC9_9RHIZ/417-569    AC A0A0F5PVC9.1
#=GS A0A2G3K8L1_9BURK/420-571    AC A0A2G3K8L1.1
#=GS A0A1E5G5E1_9BACL/130-287    AC A0A1E5G5E1.1
#=GS C4XHI3_DESMR/143-296        AC C4XHI3.1
#=GS A0A202DL59_9BACT/309-468    AC A0A202DL59.1
#=GS D3HIV1_LEGLN/411-567        AC D3HIV1.1
#=GS A0A221P0R3_9ACTN/411-546    AC A0A221P0R3.1
#=GS A0A0J6YUH4_9BACT/170-308    AC A0A0J6YUH4.1
#=GS A0A136A311_9ALTE/267-416    AC A0A136A311.1
#=GS A0A0A6UMA3_ACTUT/413-564    AC A0A0A6UMA3.1
#=GS A0A1F8PKN2_9CHLR/125-271    AC A0A1F8PKN2.1
#=GS R5QXD6_9FIRM/87-241         AC R5QXD6.1
#=GS N0B0A6_9RHIZ/348-504        AC N0B0A6.1
#=GS A0A1W6Z4G9_9BORD/77-234     AC A0A1W6Z4G9.1
#=GS A0A1G1LZI8_9BACT/329-480    AC A0A1G1LZI8.1
#=GS A0A059FCT2_9RHOB/101-256    AC A0A059FCT2.1
#=GS A0A1Y2KCI9_9PROT/65-221     AC A0A1Y2KCI9.1
#=GS A0A099D9P4_9ACTN/108-267    AC A0A099D9P4.1
#=GS F3KDI0_9GAMM/69-232         AC F3KDI0.1
#=GS D0L1E6_HALNC/210-367        AC D0L1E6.1
#=GS A0A244CNG1_9GAMM/408-565    AC A0A244CNG1.1
#=GS A0A1I1URG4_9BURK/173-336    AC A0A1I1URG4.1
#=GS G4I036_MYCRH/204-353        AC G4I036.1
#=GS S3HV59_9RHIZ/478-619        AC S3HV59.1
#=GS Q1N175_9GAMM/133-289        AC Q1N175.1
#=GS K2NPM9_9RHIZ/531-689        AC K2NPM9.1
#=GS A0A0D6KH02_9CYAN/180-338    AC A0A0D6KH02.1
#=GS A0A255HUW1_9BURK/205-367    AC A0A255HUW1.1
#=GS A0A140LDV4_9THEO/155-308    AC A0A140LDV4.1
#=GS A0A0N1LMK1_9PROT/379-537    AC A0A0N1LMK1.1
#=GS A0A0J1DCD5_9BURK/157-318    AC A0A0J1DCD5.1
#=GS K0C3U6_CYCSP/292-449        AC K0C3U6.1
#=GS W9V074_9GAMM/50-207         AC W9V074.1
#=GS A0A1G7QV14_9BACT/212-371    AC A0A1G7QV14.1
#=GS C1DD63_LARHH/218-374        AC C1DD63.1
#=GS A0A1D9MHE9_9RHOB/197-352    AC A0A1D9MHE9.1
#=GS A0A272EUE4_9RHOO/193-351    AC A0A272EUE4.1
#=GS R6VTR3_9FIRM/1-100          AC R6VTR3.1
#=GS A0A1E5CP64_9VIBR/356-507    AC A0A1E5CP64.1
#=GS A0A240U3I3_9BURK/200-325    AC A0A240U3I3.1
#=GS V6UAM4_9ACTN/186-359        AC V6UAM4.1
#=GS A0A1R3TN27_9RHIZ/159-311    AC A0A1R3TN27.1
#=GS A0A1I4JT99_9GAMM/452-624    AC A0A1I4JT99.1
#=GS A0A1V2DWZ8_9ALTE/405-562    AC A0A1V2DWZ8.1
#=GS B1XNC1_SYNP2/304-465        AC B1XNC1.1
#=GS A0A1N6K7B1_9BRAD/218-373    AC A0A1N6K7B1.1
#=GS U2H0Q9_9BURK/323-482        AC U2H0Q9.1
#=GS E3PR30_ACESD/510-664        AC E3PR30.1
#=GS A0A097QYU7_HAFAL/190-347    AC A0A097QYU7.1
#=GS A0A086WAN8_9BURK/463-620    AC A0A086WAN8.1
#=GS A0A239I6H7_9ACTN/237-389    AC A0A239I6H7.1
#=GS C9CTR9_9RHOB/248-405        AC C9CTR9.1
#=GS A0A0F0CMK2_9CLOT/135-282    AC A0A0F0CMK2.1
#=GS G8QLY2_DECSP/742-899        AC G8QLY2.1
#=GS F3KPL7_9BURK/173-335        AC F3KPL7.1
#=GS A0A1H3ICB9_9FIRM/224-375    AC A0A1H3ICB9.1
#=GS A0A257FQ46_9BURK/145-300    AC A0A257FQ46.1
#=GS A0A0S3QRQ7_THET7/235-391    AC A0A0S3QRQ7.1
#=GS H0IY54_9GAMM/391-546        AC H0IY54.1
#=GS A0A0A8DT55_9XANT/272-429    AC A0A0A8DT55.1
#=GS E8N1B3_ANATU/144-300        AC E8N1B3.1
#=GS E0SDQ7_DICD3/610-769        AC E0SDQ7.1
#=GS A0A1A9NHY0_9PROT/550-707    AC A0A1A9NHY0.1
#=GS A0A2A5LWN3_9ALTE/233-387    AC A0A2A5LWN3.1
#=GS A0A1N7SX89_9BURK/1-76       AC A0A1N7SX89.1
#=GS E0UUC4_SULAO/256-414        AC E0UUC4.1
#=GS A7H0B0_CAMC5/841-994        AC A7H0B0.1
#=GS A0A241R1K5_9GAMM/143-296    AC A0A241R1K5.1
#=GS A0A0Q9L1U5_9BACL/232-375    AC A0A0Q9L1U5.1
#=GS C6BZS4_DESAD/470-626        AC C6BZS4.1
#=GS A0A1E5BZJ9_9GAMM/368-527    AC A0A1E5BZJ9.1
#=GS Q5GZK3_XANOR/813-967        AC Q5GZK3.1
#=GS A0A239H1F3_9FIRM/361-518    AC A0A239H1F3.1
#=GS A0A0M3R9U2_9BACI/418-566    AC A0A0M3R9U2.1
#=GS A0A085FS85_9BRAD/292-451    AC A0A085FS85.1
#=GS A0A1I6KTI3_9BURK/261-427    AC A0A1I6KTI3.1
#=GS A0A0Q6A816_9BRAD/123-284    AC A0A0Q6A816.1
#=GS N9BUR3_9GAMM/322-473        AC N9BUR3.1
#=GS Q30WY0_DESAG/121-274        AC Q30WY0.2
#=GS A1SU71_PSYIN/522-663        AC A1SU71.1
#=GS Q3K4P9_PSEPF/124-277        AC Q3K4P9.1
#=GS A0A0Q8UP28_9ACTN/723-879    AC A0A0Q8UP28.1
#=GS H1G087_9GAMM/399-556        AC H1G087.1
#=GS A0A1I4PLE2_ECTMO/806-964    AC A0A1I4PLE2.1
#=GS A0A1A9MWS1_9BURK/387-543    AC A0A1A9MWS1.1
#=GS Q8YXN7_NOSS1/449-606        AC Q8YXN7.1
#=GS W0EAP6_9FIRM/18-179         AC W0EAP6.1
#=GS A0A1D9GJS3_9ALTE/144-300    AC A0A1D9GJS3.1
#=GS A0A193LH03_9GAMM/158-316    AC A0A193LH03.1
#=GS A0A0H1AMP0_9GAMM/268-424    AC A0A0H1AMP0.1
#=GS A0A0D8PTT4_9GAMM/244-392    AC A0A0D8PTT4.1
#=GS A0A1H7CSX3_9SPHN/163-314    AC A0A1H7CSX3.1
#=GS A0A0G3LL58_XANCT/168-322    AC A0A0G3LL58.1
#=GS A0A1W1YN37_9FIRM/154-312    AC A0A1W1YN37.1
#=GS A0A1S1MST0_9GAMM/406-564    AC A0A1S1MST0.1
#=GS M7NT73_9GAMM/49-206         AC M7NT73.1
#=GS A0A1W2EX26_KIBAR/336-490    AC A0A1W2EX26.1
#=GS A0A1Y2K3W0_9PROT/222-377    AC A0A1Y2K3W0.1
#=GS A0A1Y6EV64_9SPHN/341-496    AC A0A1Y6EV64.1
#=GS A0A1M5Z0R0_9FIRM/414-518    AC A0A1M5Z0R0.1
#=GS Q3J907_NITOC/778-935        AC Q3J907.1
#=GS A0A1Q8ZHT9_9CYAN/646-811    AC A0A1Q8ZHT9.1
#=GS A0A1Y6FLC6_9SPHN/219-375    AC A0A1Y6FLC6.1
#=GS A0A238KZC8_9RHOB/515-672    AC A0A238KZC8.1
#=GS A0A1G6BY97_9FIRM/216-357    AC A0A1G6BY97.1
#=GS A0A1U7P3V8_9DEIO/347-496    AC A0A1U7P3V8.1
#=GS A0A084UEA0_9RHIZ/212-367    AC A0A084UEA0.1
#=GS A0A0L0ISV8_9RHOB/177-336    AC A0A0L0ISV8.1
#=GS A0A1E4QUF1_9BURK/29-84      AC A0A1E4QUF1.1
#=GS A0A259FGN9_9PROT/324-480    AC A0A259FGN9.1
#=GS I9P4P3_9ALTE/347-493        AC I9P4P3.1
#=GS N8S1Q4_ACIGI/245-399        AC N8S1Q4.1
#=GS A0A0Q2LPI7_MYCGO/169-325    AC A0A0Q2LPI7.1
#=GS A0A1G8H707_9PSED/267-424    AC A0A1G8H707.1
#=GS A0A0V8HHZ3_9BACI/538-695    AC A0A0V8HHZ3.1
#=GS A0A254TJE7_9BURK/471-628    AC A0A254TJE7.1
#=GS A0A1E8CNV1_9GAMM/293-450    AC A0A1E8CNV1.1
#=GS J4NTQ7_9FIRM/20-163         AC J4NTQ7.1
#=GS A0A1H9GX57_9BACI/230-387    AC A0A1H9GX57.1
#=GS A0A0D6B3X6_RHOSU/172-326    AC A0A0D6B3X6.1
#=GS A0A1I2KB03_9ACTN/316-459    AC A0A1I2KB03.1
#=GS A0A1Y6EVF9_9GAMM/148-301    AC A0A1Y6EVF9.1
#=GS G3IWR7_METTV/397-559        AC G3IWR7.1
#=GS A0A259UK35_9FIRM/118-273    AC A0A259UK35.1
#=GS Q3K751_PSEPF/339-497        AC Q3K751.1
#=GS Q3K751_PSEPF/339-497        DR PDB; 5EUH D; 340-497;
#=GS Q3K751_PSEPF/339-497        DR PDB; 5EUH C; 340-497;
#=GS Q3K751_PSEPF/339-497        DR PDB; 5EUH A; 339-497;
#=GS Q3K751_PSEPF/339-497        DR PDB; 5EUH B; 339-497;
#=GS Q1ZPN4_PHOAS/255-402        AC Q1ZPN4.1
#=GS A0A1J5GNW9_9BACT/157-324    AC A0A1J5GNW9.1
#=GS A0A1H7RYG3_9ACTN/210-355    AC A0A1H7RYG3.1
#=GS A0A0B0HNJ9_9BACI/225-377    AC A0A0B0HNJ9.1
#=GS A0A209DEP0_9BACL/380-548    AC A0A209DEP0.1
#=GS A0A081BMF3_9BACT/325-490    AC A0A081BMF3.1
#=GS A0A1F6ZSL0_9BACT/120-287    AC A0A1F6ZSL0.1
#=GS A0A1B2M236_9GAMM/245-398    AC A0A1B2M236.1
#=GS G7W9C0_DESOD/221-372        AC G7W9C0.1
#=GS F3YTW8_DESAF/247-396        AC F3YTW8.1
#=GS A0A1L6JBK8_9SPHN/376-530    AC A0A1L6JBK8.1
#=GS A0A119UW07_9BURK/341-497    AC A0A119UW07.1
#=GS A0A1H3QEG2_9PSEU/493-647    AC A0A1H3QEG2.1
#=GS A0A0Q7K8N2_9ACTN/132-281    AC A0A0Q7K8N2.1
#=GS A0A0A2UWT5_9BACI/396-553    AC A0A0A2UWT5.1
#=GS A1S511_SHEAM/58-162         AC A1S511.1
#=GS A0A0D2HW03_9DELT/302-457    AC A0A0D2HW03.1
#=GS A0A2A5LT24_9ALTE/149-302    AC A0A2A5LT24.1
#=GS A0A0B4RCF3_9BACL/238-393    AC A0A0B4RCF3.1
#=GS A0A0R0DCN0_9GAMM/330-490    AC A0A0R0DCN0.1
#=GS A0A2G3KAR0_9BURK/202-354    AC A0A2G3KAR0.1
#=GS A0A0N8TSB6_9GAMM/217-373    AC A0A0N8TSB6.1
#=GS M1ZFD8_9FIRM/157-323        AC M1ZFD8.1
#=GS A0A1D8GCE8_9CLOT/559-716    AC A0A1D8GCE8.1
#=GS A0A1H8E5C7_9BURK/167-323    AC A0A1H8E5C7.1
#=GS V6I615_9LEPT/125-277        AC V6I615.1
#=GS A0A0F7PHB6_9RHIZ/104-253    AC A0A0F7PHB6.1
#=GS A0A0Q9YP70_9COXI/122-278    AC A0A0Q9YP70.1
#=GS A0A0B3BV76_9PSED/272-425    AC A0A0B3BV76.1
#=GS A0A1H7NJP1_9SPHN/359-516    AC A0A1H7NJP1.1
#=GS A0A1A8TDQ1_9GAMM/272-429    AC A0A1A8TDQ1.1
#=GS A0A1E7RI85_9GAMM/365-515    AC A0A1E7RI85.1
#=GS A0A1H6REF1_9LACT/172-324    AC A0A1H6REF1.1
#=GS D2SBK1_GEOOG/217-364        AC D2SBK1.1
#=GS A0A1I6Y7Y9_9MICC/81-234     AC A0A1I6Y7Y9.1
#=GS A0A1Q6WI63_9GAMM/50-206     AC A0A1Q6WI63.1
#=GS K6YRA6_9ALTE/199-348        AC K6YRA6.1
#=GS G4SW63_META2/145-305        AC G4SW63.1
#=GS A6VWI4_MARMS/557-710        AC A6VWI4.1
#=GS A0A261SPH3_9BORD/348-504    AC A0A261SPH3.1
#=GS A0A1J5N8F5_9GAMM/380-541    AC A0A1J5N8F5.1
#=GS A0A1Y6CB64_9ALTE/256-410    AC A0A1Y6CB64.1
#=GS A0A1I2I939_9ACTN/334-486    AC A0A1I2I939.1
#=GS A0A1Y4FVZ6_9ACTN/134-287    AC A0A1Y4FVZ6.1
#=GS A0A1G3UCZ3_9HELI/182-335    AC A0A1G3UCZ3.1
#=GS F5Z9J8_ALTNA/294-453        AC F5Z9J8.1
#=GS A0A1H0KWI8_9RHIZ/360-513    AC A0A1H0KWI8.1
#=GS A0A161X430_9CLOT/263-420    AC A0A161X430.1
#=GS A0A0M8KAM4_9CHLR/3-158      AC A0A0M8KAM4.1
#=GS A0A259UH90_9FIRM/359-519    AC A0A259UH90.1
#=GS E3G7J9_ENTLS/405-560        AC E3G7J9.1
#=GS A0A0Q9IMY6_9BRAD/272-429    AC A0A0Q9IMY6.1
#=GS A0A1W6LBH7_9BURK/223-378    AC A0A1W6LBH7.1
#=GS A0A1G6W082_9GAMM/416-572    AC A0A1G6W082.1
#=GS A0A1I2CZZ7_9ACTN/320-465    AC A0A1I2CZZ7.1
#=GS A0A261SRD2_9BORD/69-228     AC A0A261SRD2.1
#=GS A0A087MH33_9GAMM/206-370    AC A0A087MH33.1
#=GS A0A1Y6BTW7_9ALTE/263-425    AC A0A1Y6BTW7.1
#=GS A0A160N2I7_9GAMM/84-239     AC A0A160N2I7.1
#=GS D9QK97_BRESC/289-448        AC D9QK97.1
#=GS A0A222E222_9RHOB/79-229     AC A0A222E222.1
#=GS B0SPC3_LEPBP/188-347        AC B0SPC3.1
#=GS I4W5T2_9GAMM/264-421        AC I4W5T2.1
#=GS D4K5Y1_9FIRM/444-597        AC D4K5Y1.1
#=GS A0A1I5Z5H5_9BACI/315-473    AC A0A1I5Z5H5.1
#=GS A0A1L6I936_9BURK/241-399    AC A0A1L6I936.1
#=GS A0A2A3HYQ2_9ACTN/268-425    AC A0A2A3HYQ2.1
#=GS A0A0C4WRN4_9GAMM/401-519    AC A0A0C4WRN4.1
#=GS A0A246J147_9BURK/156-263    AC A0A246J147.1
#=GS A0A1T1B8T6_9DEIO/191-340    AC A0A1T1B8T6.1
#=GS A0A1C3EI92_9GAMM/135-286    AC A0A1C3EI92.1
#=GS A0A087MHQ7_9GAMM/209-366    AC A0A087MHQ7.1
#=GS A0A1Y1RVB2_9SPIO/263-420    AC A0A1Y1RVB2.1
#=GS A0A2A9G4U5_9VIBR/238-355    AC A0A2A9G4U5.1
#=GS A0A0W0YYA7_LEGSP/515-673    AC A0A0W0YYA7.1
#=GS A0A1W2BV33_9FIRM/309-456    AC A0A1W2BV33.1
#=GS A0A1G9PCU0_9BURK/334-490    AC A0A1G9PCU0.1
#=GS A0A091ATI1_9GAMM/191-351    AC A0A091ATI1.1
#=GS A1TEJ2_MYCVP/191-347        AC A1TEJ2.1
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