#=GF ID   GST_C_5
#=GF AC   PF16865.6
#=GF DE   Glutathione S-transferase, C-terminal domain
#=GF AU   Eberhardt R;0000-0001-6152-1369
#=GF SE   PDB:4ags
#=GF GA   27.00 27.00;
#=GF TC   27.00 27.00;
#=GF NC   26.90 26.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   22753509
#=GF RT   Leishmania TDR1 structure, a unique trimeric glutathione
#=GF RT   transferase capable of deglutathionylation and antimonial
#=GF RT   prodrug activation.
#=GF RA   Fyfe PK, Westrop GD, Silva AM, Coombs GH, Hunter WN;
#=GF RL   Proc Natl Acad Sci U S A. 2012;109:11693-11698.
#=GF DR   INTERPRO; IPR041695;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   Leishmania major and Trypanosoma cruzi glutathione-S-transferase
#=GF CC   (GST) has undergone gene duplication, diversification, and gene
#=GF CC   fusion leading to an four domain enzyme which contains two
#=GF CC   repeats of a GST N-terminal domain followed by a GST C-terminal
#=GF CC   domain [1].
#=GF SQ   151
#=GS A4HJ18_LEIBR/321-429      AC A4HJ18.1
#=GS A0A024T8D7_9STRA/126-220  AC A0A024T8D7.1
#=GS Q4DKI7_TRYCC/93-200       AC Q4DKI7.1
#=GS A0A024T8P1_9STRA/120-229  AC A0A024T8P1.1
#=GS A0A1X0P247_9TRYP/318-427  AC A0A1X0P247.1
#=GS T0RC32_SAPDV/3-93         AC T0RC32.1
#=GS A0A0T7BRB9_9CYAN/96-201   AC A0A0T7BRB9.1
#=GS Q31Q66_SYNE7/141-240      AC Q31Q66.1
#=GS A0A2R6NK34_9APHY/121-220  AC A0A2R6NK34.1
#=GS A0A168RKZ9_ABSGL/96-205   AC A0A168RKZ9.1
#=GS A0A1X2IPF4_9FUNG/93-204   AC A0A1X2IPF4.1
#=GS A4I8P2_LEIIN/97-204       AC A4I8P2.1
#=GS A4I8P2_LEIIN/97-204       DR PDB; 4AGS B; 321-429;
#=GS A4I8P2_LEIIN/97-204       DR PDB; 4AGS A; 321-429;
#=GS A4I8P2_LEIIN/97-204       DR PDB; 4AGS C; 321-429;
#=GS A0A163ATB0_PHYB8/97-207   AC A0A163ATB0.1
#=GS K9RTH3_SYNP3/140-237      AC K9RTH3.1
#=GS A0A2P8A2T1_9PEZI/113-216  AC A0A2P8A2T1.1
#=GS A0A1C0V1S6_9CYAN/147-245  AC A0A1C0V1S6.1
#=GS A0A1R3K9A6_9ROSI/398-501  AC A0A1R3K9A6.1
#=GS A0A1C0UTA8_9CYAN/142-240  AC A0A1C0UTA8.1
#=GS S2K176_MUCC1/95-209       AC S2K176.1
#=GS A0A1U8JF61_GOSHI/117-218  AC A0A1U8JF61.1
#=GS I1CM52_RHIO9/64-178       AC I1CM52.1
#=GS A0A2G4F4Z8_9CYAN/147-245  AC A0A2G4F4Z8.1
#=GS A0A4D9AMP2_SALSN/117-220  AC A0A4D9AMP2.1
#=GS A0A401IHL4_APHSA/142-239  AC A0A401IHL4.1
#=GS A0A367KH47_9FUNG/94-207   AC A0A367KH47.1
#=GS K9VR25_9CYAN/141-238      AC K9VR25.1
#=GS A0A367KGX0_9FUNG/96-207   AC A0A367KGX0.1
#=GS A0A1Q4R3H7_9CYAN/143-240  AC A0A1Q4R3H7.1
#=GS A0A1V9Z035_9STRA/254-358  AC A0A1V9Z035.1
#=GS T0R0N6_SAPDV/121-229      AC T0R0N6.1
#=GS A0A067C4X0_SAPPC/118-227  AC A0A067C4X0.1
#=GS A0A2T1FQ79_9CYAN/145-243  AC A0A2T1FQ79.1
#=GS Q4DKI7_TRYCC/317-426      AC Q4DKI7.1
#=GS A0A255YZB7_9PROT/97-200   AC A0A255YZB7.1
#=GS A0A067BUB5_SAPPC/117-226  AC A0A067BUB5.1
#=GS W4FUG8_9STRA/189-280      AC W4FUG8.1
#=GS A0A1V9ZXF7_9STRA/117-227  AC A0A1V9ZXF7.1
#=GS A0A0D1Z240_9PEZI/462-558  AC A0A0D1Z240.1
#=GS A0A150GXX9_GONPE/96-198   AC A0A150GXX9.1
#=GS A0A0A1PFX7_RHIZD/94-207   AC A0A0A1PFX7.1
#=GS W4FT04_9STRA/141-230      AC W4FT04.1
#=GS A0A1X2HUX6_SYNRA/93-207   AC A0A1X2HUX6.1
#=GS A0A2V0P7X5_9CHLO/204-275  AC A0A2V0P7X5.1
#=GS A0A162TI71_MUCCL/95-208   AC A0A162TI71.1
#=GS A9UQ13_MONBE/117-231      AC A9UQ13.1
#=GS A5GU39_SYNR3/148-246      AC A5GU39.1
#=GS L8LU00_9CHRO/146-237      AC L8LU00.1
#=GS A0A0B7MTA8_9FUNG/94-207   AC A0A0B7MTA8.1
#=GS A0A367KPB5_RHIST/95-206   AC A0A367KPB5.1
#=GS A0A1V9ZY30_9STRA/162-263  AC A0A1V9ZY30.1
#=GS A0A067BUS6_SAPPC/120-229  AC A0A067BUS6.1
#=GS A0A2B7Y8Z8_9EURO/148-234  AC A0A2B7Y8Z8.1
#=GS A0A168LAE8_MUCCL/101-212  AC A0A168LAE8.1
#=GS A0A0C9MS70_9FUNG/101-212  AC A0A0C9MS70.1
#=GS A0A0C9MK04_9FUNG/94-208   AC A0A0C9MK04.1
#=GS W9QL25_9ROSA/461-563      AC W9QL25.1
#=GS A0A1V9Z0M1_9STRA/117-227  AC A0A1V9Z0M1.1
#=GS T0PJI9_SAPDV/35-144       AC T0PJI9.1
#=GS A0A1U8PFU1_GOSHI/116-218  AC A0A1U8PFU1.1
#=GS A0A1C7NDL8_9FUNG/95-206   AC A0A1C7NDL8.1
#=GS A0A067CW93_SAPPC/107-196  AC A0A067CW93.1
#=GS A0A022RII8_ERYGU/177-280  AC A0A022RII8.1
#=GS Q4CZ29_TRYCC/317-426      AC Q4CZ29.1
#=GS A0A0D8ZQS0_9CYAN/140-240  AC A0A0D8ZQS0.1
#=GS T0PWZ5_SAPDV/121-229      AC T0PWZ5.1
#=GS A0A1U7J785_9CYAN/145-240  AC A0A1U7J785.1
#=GS K1PPL5_CRAGI/100-202      AC K1PPL5.1
#=GS A0A2T9ZHE3_9FUNG/97-189   AC A0A2T9ZHE3.1
#=GS A0A2G4T0H7_RHIZD/94-207   AC A0A2G4T0H7.1
#=GS W4GKN3_9STRA/135-228      AC W4GKN3.1
#=GS A0A059LI74_9CHLO/94-208   AC A0A059LI74.1
#=GS A4I8P2_LEIIN/321-429      AC A4I8P2.1
#=GS A4I8P2_LEIIN/321-429      DR PDB; 4AGS B; 321-429;
#=GS A4I8P2_LEIIN/321-429      DR PDB; 4AGS A; 321-429;
#=GS A4I8P2_LEIIN/321-429      DR PDB; 4AGS C; 321-429;
#=GS D8R5E7_SELML/155-239      AC D8R5E7.1
#=GS K9Y7Y6_HALP7/140-238      AC K9Y7Y6.1
#=GS A0A2A2TLB2_9CYAN/143-239  AC A0A2A2TLB2.1
#=GS A0A0F4QUR7_9GAMM/94-201   AC A0A0F4QUR7.1
#=GS A0A168LFR9_MUCCL/102-213  AC A0A168LFR9.1
#=GS A0A1V9ZEG1_9STRA/123-226  AC A0A1V9ZEG1.1
#=GS A0A067BUB1_SAPPC/122-227  AC A0A067BUB1.1
#=GS T0QTT0_SAPDV/114-221      AC T0QTT0.1
#=GS A0A1Y2BFG3_9FUNG/102-212  AC A0A1Y2BFG3.1
#=GS A0A067C4X2_SAPPC/121-229  AC A0A067C4X2.1
#=GS A0A0P4UMM9_9CYAN/154-244  AC A0A0P4UMM9.1
#=GS A0A1X2GBE3_9FUNG/96-202   AC A0A1X2GBE3.1
#=GS W4HCG7_9STRA/112-222      AC W4HCG7.1
#=GS A0A1V9ZPT3_9STRA/128-226  AC A0A1V9ZPT3.1
#=GS D8G100_9CYAN/147-245      AC D8G100.1
#=GS A0A1V9Z090_9STRA/118-229  AC A0A1V9Z090.1
#=GS A0A0A1PJZ6_RHIZD/96-207   AC A0A0A1PJZ6.1
#=GS A0A024USH6_9STRA/119-222  AC A0A024USH6.1
#=GS W4GLJ9_9STRA/135-228      AC W4GLJ9.1
#=GS A0A2G4SEI6_RHIZD/88-196   AC A0A2G4SEI6.1
#=GS A8GZU3_SHEPA/98-199       AC A8GZU3.1
#=GS A4EYW3_9RHOB/97-195       AC A4EYW3.1
#=GS M1X389_9NOST/57-163       AC M1X389.1
#=GS L8N7T1_9CYAN/142-240      AC L8N7T1.1
#=GS T0R0P0_SAPDV/56-158       AC T0R0P0.1
#=GS F2UCJ5_SALR5/117-228      AC F2UCJ5.1
#=GS A0A022RNK7_ERYGU/117-218  AC A0A022RNK7.1
#=GS A0A2P6VAV0_9CHLO/425-543  AC A0A2P6VAV0.1
#=GS A0A1C7N940_9FUNG/103-204  AC A0A1C7N940.1
#=GS T0QVR1_SAPDV/115-227      AC T0QVR1.1
#=GS A0A1Y1HTM6_KLENI/205-300  AC A0A1Y1HTM6.1
#=GS A0A024UTA8_9STRA/111-222  AC A0A024UTA8.1
#=GS L8H4T1_ACACA/99-212       AC L8H4T1.1
#=GS A0A165II81_EXIGL/93-208   AC A0A165II81.1
#=GS A0A0L0TA68_ALLM3/67-180   AC A0A0L0TA68.1
#=GS A4HJ18_LEIBR/97-204       AC A4HJ18.1
#=GS A0A0L0T6D3_ALLM3/131-231  AC A0A0L0T6D3.1
#=GS B7KL51_CYAP7/139-239      AC B7KL51.1
#=GS A0A0D2QIW4_GOSRA/117-218  AC A0A0D2QIW4.1
#=GS A0A1C7N9A3_9FUNG/61-172   AC A0A1C7N9A3.1
#=GS A0A1X2GCP4_9FUNG/121-203  AC A0A1X2GCP4.1
#=GS A0A0M1JMS9_9CYAN/147-245  AC A0A0M1JMS9.1
#=GS W4HAC4_9STRA/118-222      AC W4HAC4.1
#=GS A0A2T9YWI7_9FUNG/97-209   AC A0A2T9YWI7.1
#=GS U5DLV0_9CHRO/140-240      AC U5DLV0.1
#=GS G2IN94_SPHSK/95-205       AC G2IN94.1
#=GS G2IN94_SPHSK/95-205       DR PDB; 4YAV A; 95-205;
#=GS G2IN94_SPHSK/95-205       DR PDB; 4YAP A; 95-205;
#=GS A0A1R3HGM2_COCAP/493-590  AC A0A1R3HGM2.1
#=GS A0A367IMY8_RHIST/52-163   AC A0A367IMY8.1
#=GS A0A165ANS3_9APHY/66-148   AC A0A165ANS3.1
#=GS K9Z199_CYAAP/155-239      AC K9Z199.1
#=GS A0A1V9YZY1_9STRA/117-226  AC A0A1V9YZY1.1
#=GS Q4CZ29_TRYCC/93-200       AC Q4CZ29.1
#=GS A0A1U8PFN9_GOSHI/116-218  AC A0A1U8PFN9.1
#=GS G4QF58_GLANF/109-200      AC G4QF58.1
#=GS A0A067BTL6_SAPPC/118-229  AC A0A067BTL6.1
#=GS A0A067BVQ3_SAPPC/117-226  AC A0A067BVQ3.1
#=GS A0A1X2ITW2_9FUNG/95-205   AC A0A1X2ITW2.1
#=GS K9V1J9_9CYAN/143-239      AC K9V1J9.1
#=GS A0A1R0GUI7_9FUNG/96-181   AC A0A1R0GUI7.1
#=GS K5UTW3_PHACS/122-223      AC K5UTW3.1
#=GS A0A1X0P247_9TRYP/94-201   AC A0A1X0P247.1
#=GS A0A1H9ZMW5_THASX/99-197   AC A0A1H9ZMW5.1
#=GS Q70GE8_LEIMA/97-204       AC Q70GE8.1
#=GS A0A068SC34_9FUNG/91-205   AC A0A068SC34.1
#=GS S2JI82_MUCC1/101-212      AC S2JI82.1
#=GS T0PTI3_SAPDV/60-156       AC T0PTI3.1
#=GS T0PY11_SAPDV/174-263      AC T0PY11.1
#=GS K9YWX5_DACSA/143-238      AC K9YWX5.1
#=GS A0A2T9Y0U1_9FUNG/160-272  AC A0A2T9Y0U1.1
#=GS A0A498K512_MALDO/115-216  AC A0A498K512.1
#=GS E1ZHD6_CHLVA/99-217       AC E1ZHD6.1
#=GS Q70GE8_LEIMA/321-429      AC Q70GE8.1
#=GS L8GFR3_ACACA/88-196       AC L8GFR3.1
#=GS A0A1V9YU91_9STRA/119-216  AC A0A1V9YU91.1
#=GS A0A0C9Z9N8_9AGAM/121-203  AC A0A0C9Z9N8.1
#=GS K9RDG2_9CYAN/142-240      AC K9RDG2.1
#=GS E0ULF3_CYAP2/145-239      AC E0ULF3.1
#=GS A0A175W6F0_9PEZI/511-582  AC A0A175W6F0.1
#=GS T0R7R9_SAPDV/121-229      AC T0R7R9.1
A4HJ18_LEIBR/321-429                 ...............................................YEVGFFLDN.A.G.Y.FV.T.GL.L.S.WFF..G...G...-..S.E...D.....A.....K..A...E...F..E....W......A....A....V....E..L..E...Q..Q.....L....AK....HP.....fGE..GPFFGG.KTMNAGDVAI.LPFLVRVKSLT.P.E.L..tNG..Y.D..F..F.....A.....K......FPLL....NELAEAGM.VTPEAKA-v...............................
A0A024T8D7_9STRA/126-220             ..................................avakfeakpfyae---------.-.-.-.--.-.--.-.-.---..-...-...-..-.-...-.....-.....-..A...E...V..R....E......I....L....A....E..L..E...T..I.....Y....TN....HAka..yrDQ..GPYLLG.ANLSSAEINL.VPFFFRFDVLL.T.H.Y...HK..V.D..V..F.....T.....D......IPHL....KAALAAAV.GRPAFQQ-t...............................
Q4DKI7_TRYCC/93-200                  ...............................................HRVEFFLSE.I.G.D.LV.K.AY.F.G.LVR..D...P...F..N.E...E.....K.....R..K...S...V..D....H......N....T....A....Y..I..E...G..I.....I....AE....HQ......GD..GPYFLD.DTFSMAEVMV.VPFLACFRPVL.S.Y.Y...CG..Y.D..I..F.....H.....E......APRL....KKMYVTSM.QRTTVKET................................
A0A024T8P1_9STRA/120-229             ..............................stvaqlviakfdalpwy---------.-.-.-.--.-.--.-.Q.YLR..T...G...-..D.E...K.....A.....K..V...E...G..K....E......N....L....Q....V..V..E...T..I.....F....TV....NAka..ysEH..GPYLLG.ADLSSAEINL.FPFFYRLEILL.G.H.Y...RQ..L.D..F..L.....A.....D......YPTL....KAAFDAAK.SRKAFQ--qt..............................
A0A1X0P247_9TRYP/318-427             ...............................................YYVRFAESN.A.S.Y.FH.S.AM.Y.G.LMK..N...P...Q..D.K...G.....A.....K..E...D...I..E....W......V....G....S....E..L..E...K..Q.....L....KE....QH.....fGA..GPFFGG.NKMNAADVYV.LPMLVRMKACA.P.E.L..tGG..Y.D..F..F.....A.....K......HKLL....EALVDAGL.ASEAGK--kv..............................
T0RC32_SAPDV/3-93                    ..........................................ktpnm---------.-.-.-.--.-.--.-.-.---..-...P...L..E.A...E.....M.....R..T...S...L..Q....G......L....E....R....I..Y..R...E..H.....A....AA....FR......AK..GPYLLG.DRFSSAEINI.MTFLFRFDILL.Q.H.Y...RQ..V.R..V..L....gD.....D......IPLL....SAALEASM.ARPA----ftlt............................
A0A0T7BRB9_9CYAN/96-201              .........................................idfant---------.-.-.R.FV.T.AF.S.N.LLR..S...PdseT..Q.E...E.....A.....R..R...D...L..Y....K......H....L....E....F..V..E...N..Q....aL....AK....LS......GN..GSYWFG.ENISLVDLSF.YPWFERL-PAL.E.Y.Y...RG..F.K..L..P.....S.....E......FTRL....QQWQNAVS.QRESVQK-i...............................
Q31Q66_SYNE7/141-240                 .........................relfrawcgwlcypsrspqqdq---------.-.-.-.--.-.--.-.-.---..-...-...-..-.-...Q.....G.....R..T...A...F..Q....A......V....V....D....R..V..E...A..A.....L....AS....--......TP..GPYFLE.-CFGVTDVIF.TPYVERMNASL.F.Y.Y...KG..Y.S..L..R.....E.....I......NPRL....SDWFEAME.SRETYR--gt..............................
A0A2R6NK34_9APHY/121-220             ...................................idfinknivpln---------.-.-.-.--.-.--.M.R.LIM..A...Q...E..P.E...K.....Q.....K..A...Y...L..E....E......Y....T....A....A..L..R...T..Y.....T....S-....-K......VK..GPYFLG.EEFTLADVAI.APWIMRD-YVL.T.E.H...RG..Y.N..R..A.....E.....V......SPEW....KAYADIVE.KRKSV---vnt.............................
A0A168RKZ9_ABSGL/96-205              ......................................faiefyssk---------.-.-.-.II.P.NL.Y.A.ILK..N...P...D..Q.K...E....sI.....V..Q...E...L..N....V......A....Y....Q....R..F..E...E..L.....L....LE....QS......AD..GPYFYG.DKFSLVDIAI.APFAGRFNALF.EvA.F..kKG..Y.QptT..V.....Q.....A......SPRL....TSYLDALV.NRPSFKE-s...............................
A0A1X2IPF4_9FUNG/93-204              ..............................................a-QIRFFIEY.F.N.K.LW.T.NL.F.K.HIT..G...Q...L..SlE...D.....Y.....I..K...E...A..E....P......V....W....I....R..V..N...E..L.....L....LE....QS......QT..GPYFLG.DQFSLADVAL.APFIARIRAVT.S.R.S..eAG..F.E..FkaV.....K.....E......NPRL....AQFLQGVL.DRPSFKE-s...............................
A4I8P2_LEIIN/97-204                  ...............................................HQIEFFLAQ.V.G.D.FI.G.AA.H.G.LLR..D...P...L..S.G...E.....K.....R..K...A...M..D....D......N....A....A....Y..V..D...G..L.....L....AA....NQ......TT..GPYYCD.GEFTMADVAL.VPFLVRLKPAL.M.Y.Y...AG..Y.D..V..F.....C.....K......APRM....KALWAAAA.QRASVRET................................
#=GR A4I8P2_LEIIN/97-204       SS    ...............................................HHHHHHHHH.H.H.H.HH.H.HH.H.H.HHH..S...T...T..-.H...H.....H.....H..H...H...H..H....H......H....H....H....H..H..H...H..H.....H....HH....H-......SS..-SEEEE.EE--HHHHHH.HHHHHHHHHHH.H.H.H...HS..-.-..T..T.....T.....T......-HHH....HHHHHHHT.TSHHHHTT................................
A0A163ATB0_PHYB8/97-207              .................faieyfatkisspwykvlfnygdetkegfi---------.-.-.-.--.-.--.-.-.---..-...-...-..-.-...-.....-.....-..K...E...T..E....A......G....F....T....R..L..G...E..L.....L....RE....QS......ET..GPYFLG.EEYSLADVAI.APFLGRVLLTF.K.H.W..vGD..Y.KhkA..I.....Q.....N......DKRL....EAFVEGIL.SRPSFKET................................
K9RTH3_SYNP3/140-237                 ...........................................rllf---------.-.-.-.--.R.AW.C.N.WLC..Y...P...-..T.R...S.....A.....R..E...E...V..Q....N......K....A....Q....F..L..QvvaQ..V.....E...aAL....AQ......TP..GPFFLE.-EFSTADVVF.VPYVERMNASL.F.Y.Y...KG..Y.S..L..R.....E.....E......NPSL....GE------.--------wftgletlptyr....................
A0A2P8A2T1_9PEZI/113-216             ..............................................a-RVNFFVDN.W.F.S.KV.N.SK.M.Y.PIM..L...A...E..S.D...E.....K.....K..E...E...L.vK....E......V....I....A....A..V..E...K..E.....I....EP....HL.....kDA..GPFFGGsSKLTMAEVLT.APFVIRFKT--.-.-.-...--..-.-..-..-.....-.....-......----....--------.--------ysngefmptslsegleklpnfskwaa......
A0A1C0V1S6_9CYAN/147-245             ...........................llfrawcswlcypsssakve---------.-.-.-.--.-.--.-.-.---..-...-...-..-.Q...H.....N.....R..H...Q...F..I....S......V....V....A....Q..M..E...A..A.....L....AN....--......TP..GPYFLE.-EFGTVDVIF.TPYVERMNASL.Y.Y.Y...KG..Y.S..M..R.....E.....E......NPRF....ADWFAAME.SRPTYR--gt..............................
A0A1R3K9A6_9ROSI/398-501             ...........................................ekkk-----FFEE.L.G.S.YV.D.KF.L.G.TVF..T...S...F..K.G...D.....T.....T..K...E...V..G....P......A....F....D....Y..L..E...N..A.....L....--....HK......FD..GPFLLG.-EFSLADIAY.ITFVERFQIFL.S.E.V...FQ..Y.D..I..V.....A.....G......RPKL....AAWIEEAN.--------kidayrqt........................
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#=GC SS_cons                         .............................................HHHHHHHHHHHTH.H.H.HH.H.HH.H.H.HHH..C--GC...C..H.H...H.....H.....H..H...H...H..H....H......H....H....H....H..H..H...H..H.....H....HH....HT.....TSS..SSCCCC.TC--HHHHHH.HHHHHHHHHHH.H.H.H..TCT..-.-..C..C.....T.....T......-HHH....HHHHHHHH.TSHHHHCC-SS.............................
#=GC seq_cons                        ..............................................t............................................t.t...c.....h.....c..p...p...h..p....p......s....h....s....p..l..-...c..h.....l....sp....tt......ss..GPYaLG.pcaShADlsh.sPalhRhphhL.p.p.a...cu..a.-..l..h.....p.....p......hPpL....sthhpuh..tRsshp..................................
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