GenomeNet

Database: Pfam
Entry: HNF-1A_C
LinkDB: HNF-1A_C
Original site: HNF-1A_C 
#=GF ID   HNF-1A_C
#=GF AC   PF04813.12
#=GF DE   Hepatocyte nuclear factor 1 (HNF-1), alpha isoform C terminus
#=GF AU   Kerrison ND;0000-0002-1471-953X
#=GF SE   Pfam-B_2624 (release 7.6)
#=GF GA   27.30 27.30;
#=GF TC   38.90 35.90;
#=GF NC   22.60 22.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 45638612 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   7900999
#=GF RT   More potent transcriptional activators or a transdominant
#=GF RT   inhibitor of the HNF1 homeoprotein family are generated by
#=GF RT   alternative RNA processing. 
#=GF RA   Bach I, Yaniv M; 
#=GF RL   EMBO J 1993;12:4229-4242.
#=GF RN   [2]
#=GF RM   9133564
#=GF RT   A prevalent amino acid polymorphism at codon 98 in the
#=GF RT   hepatocyte nuclear factor-1alpha gene is associated with reduced
#=GF RT   serum C-peptide and insulin responses to an oral glucose
#=GF RT   challenge. 
#=GF RA   Urhammer SA, Fridberg M, Hansen T, Rasmussen SK, Moller AM,
#=GF RA   Clausen JO, Pedersen O; 
#=GF RL   Diabetes 1997;46:912-916.
#=GF DR   INTERPRO; IPR006898;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family consists of an alternative C terminus of
#=GF CC   homeobox-containing transcription factor HNF-1, found in the
#=GF CC   HNF-1A isoform.  Different isoforms of HNF-1 are generated by
#=GF CC   the differential use of polyadenylation sites and by alternative
#=GF CC   splicing.                      The C-terminal region of HNF-1 is
#=GF CC   responsible for the activation of transcription, and HNF-1A,
#=GF CC   which has this C-terminal extension, transactivates less well
#=GF CC   than the B and C isoforms [1]. Mutations and polymorphisms in
#=GF CC   HNF-1 cause the type 3 form of maturity-onset diabetes of the
#=GF CC   young (MODY3) [2].
#=GF SQ   101
#=GS A0A2I3M205_PAPAN/365-453  AC A0A2I3M205.1
#=GS A0A226P131_COLVI/546-633  AC A0A226P131.1
#=GS A0A1S3WEG7_ERIEU/540-627  AC A0A1S3WEG7.1
#=GS E0YMJ1_HUMAN/138-226      AC E0YMJ1.1
#=GS A0A2I3T729_PANTR/573-661  AC A0A2I3T729.1
#=GS G7N601_MACMU/542-630      AC G7N601.1
#=GS W5KDZ5_ASTMX/492-561      AC W5KDZ5.1
#=GS HNF1A_MOUSE/540-627       AC P22361.2
#=GS A0A0F8D1R5_LARCR/488-556  AC A0A0F8D1R5.1
#=GS A0A226NBL9_CALSU/546-633  AC A0A226NBL9.1
#=GS H3BXN4_TETNG/522-590      AC H3BXN4.1
#=GS G1PCX9_MYOLU/539-627      AC G1PCX9.1
#=GS M7C177_CHEMY/526-613      AC M7C177.1
#=GS A0A2K5NWR4_CERAT/365-453  AC A0A2K5NWR4.1
#=GS A0A1L8I0A9_XENLA/509-593  AC A0A1L8I0A9.1
#=GS A0A2K5J3P3_COLAP/542-630  AC A0A2K5J3P3.1
#=GS L9KRL7_TUPCH/542-630      AC L9KRL7.1
#=GS F6Q5D3_MONDO/571-612      AC F6Q5D3.2
#=GS A0A2K5NW02_CERAT/573-661  AC A0A2K5NW02.1
#=GS A0A1S2WYW7_SALSA/515-558  AC A0A1S2WYW7.1
#=GS H2Q721_PANTR/549-637      AC H2Q721.2
#=GS A0A2I3G3A5_NOMLE/324-412  AC A0A2I3G3A5.1
#=GS H3D1M7_TETNG/467-532      AC H3D1M7.1
#=GS A0A2I4CK97_9TELE/491-560  AC A0A2I4CK97.1
#=GS HNF1A_SALSA/515-558       AC Q91474.1
#=GS H0WZU1_OTOGA/542-630      AC H0WZU1.1
#=GS K7G2U5_PELSI/545-632      AC K7G2U5.1
#=GS A0A218V2Q6_9PASE/546-633  AC A0A218V2Q6.1
#=GS H0V9M5_CAVPO/539-627      AC H0V9M5.1
#=GS HNF1A_HUMAN/542-630       AC P20823.2
#=GS A0A1D5R0W9_MACMU/573-661  AC A0A1D5R0W9.1
#=GS H9KX05_CALJA/224-312      AC H9KX05.1
#=GS A0A1L1RPG1_CHICK/546-633  AC A0A1L1RPG1.1
#=GS A0A1A6HQR7_NEOLE/311-354  AC A0A1A6HQR7.1
#=GS A0A1S2ZVP4_ERIEU/533-620  AC A0A1S2ZVP4.1
#=GS G3WPM8_SARHA/544-636      AC G3WPM8.1
#=GS H2UWZ1_TAKRU/499-583      AC H2UWZ1.1
#=GS H3C3K4_TETNG/522-596      AC H3C3K4.1
#=GS A0A2I2ZCZ2_GORGO/573-661  AC A0A2I2ZCZ2.1
#=GS A0A1S3F1B9_DIPOR/542-630  AC A0A1S3F1B9.1
#=GS H0ZHD2_TAEGU/545-632      AC H0ZHD2.1
#=GS A0A0D9S4M1_CHLSB/542-631  AC A0A0D9S4M1.1
#=GS G1S1E9_NOMLE/449-537      AC G1S1E9.2
#=GS A0A1D5QAI7_MACMU/582-670  AC A0A1D5QAI7.1
#=GS HNF1A_CHICK/546-633       AC Q90867.1
#=GS G3QNW9_GORGO/542-630      AC G3QNW9.1
#=GS W5PWE7_SHEEP/567-653      AC W5PWE7.1
#=GS A0A2D0QVD0_ICTPU/506-575  AC A0A2D0QVD0.1
#=GS A0A2I2Y531_GORGO/365-453  AC A0A2I2Y531.1
#=GS F1PJ35_CANLF/542-630      AC F1PJ35.1
#=GS A0A2I3TKC6_PANTR/365-453  AC A0A2I3TKC6.1
#=GS A0A0A0MTK8_HUMAN/573-661  AC A0A0A0MTK8.1
#=GS A0A0Q3U1U1_AMAAE/543-630  AC A0A0Q3U1U1.1
#=GS A0A2I3HRE5_NOMLE/473-561  AC A0A2I3HRE5.1
#=GS A0A2K5J3N0_COLAP/573-661  AC A0A2K5J3N0.1
#=GS F2Z4S1_DANRE/489-559      AC F2Z4S1.1
#=GS A0A1D5QUU5_MACMU/373-445  AC A0A1D5QUU5.1
#=GS A0A091CZU1_FUKDA/542-630  AC A0A091CZU1.1
#=GS G3PGQ4_GASAC/494-563      AC G3PGQ4.1
#=GS E0YMI9_HUMAN/363-451      AC E0YMI9.1
#=GS T0MDX2_CAMFR/511-599      AC T0MDX2.1
#=GS Q4PJJ8_PIG/542-630        AC Q4PJJ8.1
#=GS A0A2D0QXA6_ICTPU/510-579  AC A0A2D0QXA6.1
#=GS U3JYI0_FICAL/548-635      AC U3JYI0.1
#=GS A0A096MVZ6_PAPAN/549-637  AC A0A096MVZ6.2
#=GS G5AWX7_HETGA/542-630      AC G5AWX7.1
#=GS F6Q5D3_MONDO/541-573      AC F6Q5D3.2
#=GS A0A087Y4Z6_POEFO/492-561  AC A0A087Y4Z6.1
#=GS L5KWI4_PTEAL/380-468      AC L5KWI4.1
#=GS F1MD26_BOVIN/544-632      AC F1MD26.1
#=GS A0A2I0LZ40_COLLI/543-630  AC A0A2I0LZ40.1
#=GS B7ZRG9_XENLA/412-499      AC B7ZRG9.1
#=GS A0A1U8CZX6_ALLSI/546-599  AC A0A1U8CZX6.1
#=GS G7PJ58_MACFA/542-630      AC G7PJ58.1
#=GS A0A2K5J3U0_COLAP/365-453  AC A0A2K5J3U0.1
#=GS E1BQ64_CHICK/521-608      AC E1BQ64.3
#=GS M3XW08_MUSPF/544-632      AC M3XW08.1
#=GS A0A2I3MWC9_PAPAN/573-661  AC A0A2I3MWC9.1
#=GS A0A2K5NWJ9_CERAT/542-630  AC A0A2K5NWJ9.1
#=GS A0A1U7TI53_TARSY/138-226  AC A0A1U7TI53.1
#=GS R0L7K0_ANAPL/546-633      AC R0L7K0.1
#=GS A0A0A0MQU7_HUMAN/542-630  AC A0A0A0MQU7.1
#=GS F7CR09_HORSE/544-632      AC F7CR09.1
#=GS L5LFW4_MYODS/116-204      AC L5LFW4.1
#=GS A0A151N4D0_ALLMI/546-633  AC A0A151N4D0.1
#=GS F5H0K0_HUMAN/549-637      AC F5H0K0.1
#=GS HNF1A_RAT/540-627         AC P15257.1
#=GS I3JYX7_ORENI/492-577      AC I3JYX7.1
#=GS M3WBT5_FELCA/543-631      AC M3WBT5.1
#=GS G1LP62_AILME/542-630      AC G1LP62.1
#=GS M3ZMP9_XIPMA/490-559      AC M3ZMP9.1
#=GS A0A1L8HQ75_XENLA/517-604  AC A0A1L8HQ75.1
#=GS A0A1V4JRS9_PATFA/543-630  AC A0A1V4JRS9.1
#=GS A0A1S3WE68_ERIEU/539-626  AC A0A1S3WE68.1
#=GS G3HI63_CRIGR/579-667      AC G3HI63.1
#=GS A0A1U7QQX3_MESAU/541-629  AC A0A1U7QQX3.1
#=GS A0A1U7R9V2_ALLSI/546-633  AC A0A1U7R9V2.1
#=GS G3TJQ6_LOXAF/542-630      AC G3TJQ6.1
#=GS I3JYX6_ORENI/489-558      AC I3JYX6.1
#=GS H2NIW9_PONAB/258-346      AC H2NIW9.1
#=GS H2UWZ0_TAKRU/487-555      AC H2UWZ0.1
A0A2I3M205_PAPAN/365-453             ...............................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASPT.VSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS..
A0A226P131_COLVI/546-633             ..............................a-FTPDSETHTDSGIHTPV.SQAPAIHLQNQDT.....T-IQHLQPGPRL.TSSPA.VSSSSLVLYQSSDSTNSH.SQL.LPSTHNVIETFISTQMASST..
A0A1S3WEG7_ERIEU/540-627             ...............................VFTSEAEASSESGLPTPV.SQATTIHIPNQDP.....GGIQHLQP-HRL.SASPS.VSSSSLVLYQSSDSTNGH.SHL.LPSSHSVIETFISTQMASSS..
E0YMJ1_HUMAN/138-226                 ...............................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....ASIQHLQPAHRL.SASPT.VSSSSLVLYQSSDSSNGQ.SHL.LPSNHSVIETFISTQMASSS..
A0A2I3T729_PANTR/573-661             ...............................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASPT.VSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS..
G7N601_MACMU/542-630                 ...............................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASPT.VSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS..
W5KDZ5_ASTMX/492-561                 ..............................t-LSSDPEDHTDTPIQE--.---ESLHLQPSSP.....IP----------.-----.VSSGSLELYSQSQSSETHtSHL.LASPPGEIDPYIPAQMVSTA..
HNF1A_MOUSE/540-627                  ...............................VFTSDTEASSEPGLHEPP.SPATTIHIPSQDP.....SNIQHLQPAHRL.STSPT.VSSSSLVLYQSSDS-NGH.SHL.LPSNHSVIETFISTQMASSS..
A0A0F8D1R5_LARCR/488-556             ...............................ILTADPEEQTDSPLQE--.---DSLHLQPHTP.....VP----------.-----.ASSESLELYPASQSTDSHqSHL.LSPSPTDI-SYIPTQMVSTA..
A0A226NBL9_CALSU/546-633             ..............................a-FTSDSETHTDSGIHTPV.SQAPAIHLQNQDT.....T-IQHLQPGPRL.TSSPA.VSSSSLVLYQSSDSTNSH.SQL.LPSTHNVIETFISTQMASST..
H3BXN4_TETNG/522-590                 .............................cs--STDEEDQTGSPMQE--.---DSLHMQPNTP.....IP----------.-----.ASSESLELYPPSQQSDSHpSHL.LSPSPSDI-SYIPAQMASTA..
G1PCX9_MYOLU/539-627                 ...............................VFISDTEASSESGLHTPA.SQATTIHIPSQDP.....AGIQHLQPSHRL.SASPP.VSSSSLVLYQSSESTNGH.SHL.LPSNHSVIETFISTQMASSS..
M7C177_CHEMY/526-613                 ...............................VFTSESETHTESGIHTSV.SQTPTIHLQNQDT.....T-IQHLQPGHRL.TPSPA.VSSSSLVLYHSSDSTNSH.SHL.LPSTHSVIETFIPTQMASST..
A0A2K5NWR4_CERAT/365-453             ...............................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASPT.VSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS..
A0A1L8I0A9_XENLA/509-593             ...............ltpskqvvshhptahg------------------.-DSPGSQLHNQDS.....S-ILHLHPSHRL.SPIPT.VSSASLIHYHNSSSPENH.SHL.LSPSHNTIDSFISTQMASSS..
A0A2K5J3P3_COLAP/542-630             ...............................VFTSDPEASSESGLHTPA.SQATTLHVPSQDP.....ASIQHLQPAHRL.SASPT.VSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS..
L9KRL7_TUPCH/542-630                 ...............................VFTSDPEAAGESGLHTPA.SQATTLHVPNQDS.....AGIQHLQPTHRL.SASPT.VSSSSLVLYQSSDSTNGH.SHL.LPSNHSVIETFISTQMASSS..
F6Q5D3_MONDO/571-612                 ..............................p------------------.-------------.....------------.-----.VSSSSLVLYQGSDSTNSH.SQL.LSSNHGVIETFISTHMASSS..
A0A2K5NW02_CERAT/573-661             ...............................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASPT.VSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS..
A0A1S2WYW7_SALSA/515-558             .............................vp------------------.-------------.....------------.-----.VSSGNLQLYPPSQSSESHpPHR.LSSSPADINSYIPAQMVSTA..
H2Q721_PANTR/549-637                 ...............................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASPT.VSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS..
A0A2I3G3A5_NOMLE/324-412             ...............................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASPT.VSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS..
H3D1M7_TETNG/467-532                 pqypsssllsqalviadssslgtltsltavr------------------.-------------.....------------.-----.------QLYPPSQQSDSHpSHL.LSPSPSDI-SYIPAQMASTA..
A0A2I4CK97_9TELE/491-560             ...............................ILTADPEEGTDSPLQD--.---DSLHLQPHTP.....VP----------.-----.ASSESLELYPSSQMTERHpSHI.LSPSPTDISSYMPTQMVSTA..
HNF1A_SALSA/515-558                  .............................vp------------------.-------------.....------------.-----.VSSGNLQLYPPSQSSESHpPHR.LSSSPADINSYIPAQMVSTA..
H0WZU1_OTOGA/542-630                 ...............................VFTSDPEASSESGLHTPA.SQATTLHVPSQDP.....AGIQHLQPTHRL.SASPT.VSSSSLVLYQSSDSSNGH.SHL.LPSNHGVIETFISTQMASSS..
K7G2U5_PELSI/545-632                 ...............................VFTSESETHTESGIHTSV.SQTPTIHLQNQDT.....A-IQHLQPSHRL.TPSPA.VSSSNLVLYQSSDSTNSH.SHL.LPSTHSVIETFIPTQMASST..
A0A218V2Q6_9PASE/546-633             ..............................a-FTPDSETHTESGMHTPV.SQAPTIHLQNQDT.....T-IQHLQPGPRL.TSSPA.VSSSSLVLYQSSDSTNSH.SQL.LSSTHNVIETFISTQMASST..
H0V9M5_CAVPO/539-627                 ...............................VFTSDTEASSESGLHAPA.SPATTIHIPSQDP.....AGIQHLQPAHRL.STSPT.VSSSSLVLYQSSDSTNGH.SHL.LPSNHSVIETFISTQMASSS..
HNF1A_HUMAN/542-630                  ...............................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASPT.VSSSSLVLYQSSDSSNGQ.SHL.LPSNHSVIETFISTQMASSS..
A0A1D5R0W9_MACMU/573-661             ...............................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASPT.VSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS..
H9KX05_CALJA/224-312                 ...............................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASPT.MSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS..
A0A1L1RPG1_CHICK/546-633             ..............................a-FTSDSETHTDSGIHTPV.SQAPAIHLQNQDT.....A-IQHLQSGPRL.TPSPA.VSSSSLVLYQSSDSTNSH.SQL.LPSTHNVIETFISTQMASST..
A0A1A6HQR7_NEOLE/311-354             .........................tgseek------------------.-------------.....------------.-----.---NSLVLYQSSDSTNGH.SHL.LPSNHGVIETFISTQMASSS..
A0A1S2ZVP4_ERIEU/533-620             ...............................VFTSEAEASSESGLPTPV.SQATTIHIPNQDP.....GGIQHLQP-HRL.SASPS.VSSSSLVLYQSSDSTNGH.SHL.LPSSHSVIETFISTQMASSS..
G3WPM8_SARHA/544-636                 ...............................VFSSDSEAPSESGLHTPV.SQASAIHIPSQDPeagerAGAQGSRSSPA-.TLASA.VSSSSLVLYQGSDSTSSH.SQL.LSSNHGVIETFISTHMASSS..
H2UWZ1_TAKRU/499-583                 ...............................ILSADQEDHTDSPVHE--.---DSLQLQPNTP.....VPGTNTHPVTTFdGNHSL.ASSESLELYPPSQPSDSHqSHL.LSPSPSDI-SYIPAQMASTA..
H3C3K4_TETNG/522-596                 .............................cs--STDEEDQTGSPMQE--.---DSLHMQPNTP.....IPAPP-------.--TFE.ASSESLELYPPSQQSDSHpSHL.LSPSPSDI-SYIPAQMASTA..
A0A2I2ZCZ2_GORGO/573-661             ...............................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASPT.VSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS..
A0A1S3F1B9_DIPOR/542-630             ...............................VFTSDTEASSESGLHAPA.SPATTIHIPSQDP.....GSIQHLQPAHRL.SASPT.VSSSSLVLYQSSDATNGH.GHL.LPSNHGVIETFISTQMASSS..
H0ZHD2_TAEGU/545-632                 ..............................a-FTPDSETHTESGMHTPV.SQAPTIHLQNQDT.....T-IQHLQPGPRL.TSSPA.VSSSSLVLYQSSDSTNSH.SQL.LSSTHNVIETFISTQMASST..
A0A0D9S4M1_CHLSB/542-631             ...............................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASPTaVSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS..
G1S1E9_NOMLE/449-537                 ...............................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASPT.VSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS..
A0A1D5QAI7_MACMU/582-670             ...............................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASPT.VSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS..
HNF1A_CHICK/546-633                  ..............................a-FTSDSETHTDSGIHTPV.SQAPAIHLQNQDT.....A-IQHLQSGPRL.TPSPA.VSSSSLVLYQSSDSTNSH.SQL.LPSTHNVIETFISTQMASST..
G3QNW9_GORGO/542-630                 ...............................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASPT.VSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS..
W5PWE7_SHEEP/567-653                 ...............................VFSSDAEASSESGLHTRR.PPPPPIHIPGQDP.....AGIQQLQPSHRL.SASPT.VSSSSLVLYQSSDSTNGH.--L.LPSNHGVIETFISTQMASSS..
A0A2D0QVD0_ICTPU/506-575             ..............................t-LSSDSEEHTNTPIQE--.---ESLHLQSSSP.....VP----------.-----.VSSSSLDLYPQTQSSESHtSHL.LTSSPSDIGPYIPAQMVSTA..
A0A2I2Y531_GORGO/365-453             ...............................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASPT.VSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS..
F1PJ35_CANLF/542-630                 ...............................VFTSDAEASSESGLHTPA.SQTTTIHIPSQDP.....VGIQHLQPAHRL.SASPT.VSSSSLVLYQSSDSNNGH.SHL.LPSNHSVIETFISTQMASSS..
A0A2I3TKC6_PANTR/365-453             ...............................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASPT.VSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS..
A0A0A0MTK8_HUMAN/573-661             ...............................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....ASIQHLQPAHRL.SASPT.VSSSSLVLYQSSDSSNGQ.SHL.LPSNHSVIETFISTQMASSS..
A0A0Q3U1U1_AMAAE/543-630             ..............................a-FTPESETHTESGMHTPV.SQAPTIHLQNQDT.....T-IQHLQPGPRL.TSSPA.VSSSSLVLYQSSDSANSH.SQL.LPSTHNVIETFISTQMASST..
A0A2I3HRE5_NOMLE/473-561             ...............................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASPT.VSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS..
A0A2K5J3N0_COLAP/573-661             ...............................VFTSDPEASSESGLHTPA.SQATTLHVPSQDP.....ASIQHLQPAHRL.SASPT.VSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS..
F2Z4S1_DANRE/489-559                 ...............................ILTTDPEGHTESAIEE--.---DSLHLQSTSP.....E-----------.----A.GSSGSLDLYPQSQTSETHsSHLqLSSPAGDIDPYIPAQMVSTA..
A0A1D5QUU5_MACMU/373-445             .....placdraphphipgtqeaallpqvft------------------.-------------.....-----------S.DTEAS.MSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS..
A0A091CZU1_FUKDA/542-630             ...............................VFTPDTEASSESGLHAPV.SPATTIHIPSQDP.....GGIQHLQPAHRL.SASPT.VSSSSLVLYQSSDSTNGH.SHL.LPSSHSVIETFISTQMASSS..
G3PGQ4_GASAC/494-563                 ...............................ILTADPEEQRGSPLEE--.---DSLHLQPHTP.....VP----------.-----.ASSDRLELYPASQSTESHqSHL.LSPSPADISAYIPTQMVSTA..
E0YMI9_HUMAN/363-451                 ...............................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....ASIQHLQPAHRL.SASPT.VSSSSLVLYQSSDSSNGQ.SHL.LPSNHSVIETFISTQMASSS..
T0MDX2_CAMFR/511-599                 ...............................VFTSDAEASSESGLHTPA.SQATTIHIPSQDP.....AGIQHLQPTHRL.SASPT.VSSSSLVLYQSSDSTNGH.SHL.LPSNHSVIETFISTQMASSS..
Q4PJJ8_PIG/542-630                   ...............................VFTSDTEASSESGLHTPA.SQATTIHIPSQDP.....AGIQHLQPAHRL.SASPT.VSSSSLVLYQSSDSTNGH.SHL.LPSNHSVIETFISTQMASSS..
A0A2D0QXA6_ICTPU/510-579             ..............................t-LSSDSEEHTNTPIQE--.---ESLHLQSSSP.....VP----------.-----.VSSSSLDLYPQTQSSESHtSHL.LTSSPSDIGPYIPAQMVSTA..
U3JYI0_FICAL/548-635                 ..............................a-FTPDSETHTESGMHTPV.SQAPTIHLQNQDT.....T-IQHLQPGPRL.TSSPA.VSSSSLVLYQSSDSTNSH.SQL.LPSTHNVIETFISTQMASST..
A0A096MVZ6_PAPAN/549-637             ...............................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASPT.VSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS..
G5AWX7_HETGA/542-630                 ...............................VFTSDTEASSESGLHAPV.SPATTIHIPSQDP.....GGIQHLQPAHRL.STSPT.VSSSSLVLYQSSDSTNGH.SHL.LPSSHSVIETFISTQMASSS..
F6Q5D3_MONDO/541-573                 ...............................VFSSDSEAPSESGLHTPV.SQASTIHIPSQDP.....V-----------.-----.------------------.---.--------------------s.
A0A087Y4Z6_POEFO/492-561             ...............................ILTADPEEETDSPLQE--.---DSLHLQPHTP.....VP----------.-----.ASSESLELYPSSQTTERHqSHL.LSPSPTDIGSYMPTQMVSTA..
L5KWI4_PTEAL/380-468                 ...............................VFTSDNEASSESGLHTPA.SQATTIHIPSQDP.....AGIQHLQPSHRL.SASPT.VSSSSLVLYQSSESTNGH.SHL.LPSNHSVIETFISTQMASSS..
F1MD26_BOVIN/544-632                 ...............................VFTSDAEASSESGLHTPV.SQTTTIHIPGQDP.....AGIQQLQPSHRL.SASPT.VPSSSLVLYQSSDSTNGH.SHL.LPSNHSVTETFISTQMASSS..
A0A2I0LZ40_COLLI/543-630             ..............................a-FTSDSETHTESGMHTPV.SQAPTIHLQNQDT.....T-IQHLQPGPRL.TSSPA.VSSSSLVLYQSSDSTNSH.SQL.LPSTHNAMETFISTQMASST..
B7ZRG9_XENLA/412-499                 ......................ltsltpskq----------VVPLHTTAhGDAPGSQLQNQDS.....S-ILHLPLCHRL.SPIPT.VSSASLVHYHNSSSPENH.SHL.LSPSHNTIDSFISTQMASSS..
A0A1U8CZX6_ALLSI/546-599             ...............................VFTSDSENHTESGIHTPV.SQTQTIHLQNQDT.....T-IQHLQPGPRL.TSSPA.GKNKS-------------.---.--------------------il
G7PJ58_MACFA/542-630                 ...............................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASPT.VSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS..
A0A2K5J3U0_COLAP/365-453             ...............................VFTSDPEASSESGLHTPA.SQATTLHVPSQDP.....ASIQHLQPAHRL.SASPT.VSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS..
E1BQ64_CHICK/521-608                 ..............................a-FTSDSETHTDSGIHTPV.SQAPAIHLQNQDT.....A-IQHLQSGPRL.TPSPA.VSSSSLVLYQSSDSTNSH.SQL.LPSTHNVIETFISTQMASST..
M3XW08_MUSPF/544-632                 ...............................VFASDTEASSESGLHTPA.SQTTTIHIPSQDP.....AGIQHLQPAHRL.SASPT.VSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS..
A0A2I3MWC9_PAPAN/573-661             ...............................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASPT.VSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS..
A0A2K5NWJ9_CERAT/542-630             ...............................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASPT.VSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS..
A0A1U7TI53_TARSY/138-226             ...............................VFTSDTKASSASGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASPT.VSSSSLVLYQSSDSSNGH.GHL.LPSSHSVIETFISMQMASSS..
R0L7K0_ANAPL/546-633                 ..............................a-FTSDSETHTESGMHTPV.SQAPTIHLQNQDT.....T-IQHLQPGPRL.TSSPA.VSSSSLVLYQSSDSTNSH.SQL.LPSSHNVIETFISTQMASST..
A0A0A0MQU7_HUMAN/542-630             ...............................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....ASIQHLQPAHRL.SASPT.VSSSSLVLYQSSDSSNGQ.SHL.LPSNHSVIETFISTQMASSS..
F7CR09_HORSE/544-632                 ...............................VFTTDTEASSESGLHPPV.SQATTIHIPSQDS.....AGIQHLQPAHRL.STSPT.VSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS..
L5LFW4_MYODS/116-204                 ...............................VFISDTEASSESGLHTPA.SQATTIHIPSQDP.....AGIQHLQPSHRL.SASPP.VSSSSLVLYQSSESTNGH.GHL.LPSNHSVIETFISTQMASSS..
A0A151N4D0_ALLMI/546-633             ...............................VFTSDSENHTESGIHTPV.SQTQTIHLQNQDT.....T-IQHLQPGPRL.TSSPA.ASSSSLVLYQSSDSTNSH.SHL.LPSTHSVIETFISAQMASST..
F5H0K0_HUMAN/549-637                 ...............................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....ASIQHLQPAHRL.SASPT.VSSSSLVLYQSSDSSNGQ.SHL.LPSNHSVIETFISTQMASSS..
HNF1A_RAT/540-627                    ...............................VFTSDTEASSEPGLHEPS.SPATTIHIPSQDP.....SNIQHLQPAHRL.STSPT.VSSSSLVLYQSSDS-NGH.SHL.LPSNHGVIETFISTQMASSS..
I3JYX7_ORENI/492-577                 ...............................ILTTDPDEQEDAPLQE--.---DSLNMQPHSP.....APAQHRQKLHVTdTIKLT.VSSESLELYPSSQATESHqSHL.LSPSPTEISSYIPAQMVSTA..
M3WBT5_FELCA/543-631                 ...............................VFASDTEASSESGLHTPA.SQTTTIHIPSQDP.....AGIQPLQPTHRL.SASPT.VSSSSLVLYQSSDSNDGH.SHL.LPSNHSVIETFISTQMASSS..
G1LP62_AILME/542-630                 ...............................VFTADTEASSEPGLHTPA.SQTTTIHIPSQDP.....AGIQHLQPAHRL.SASPT.VSSSSLVLYQSSDSNNGH.SHL.LPSNHSVIETFISTQMASSS..
M3ZMP9_XIPMA/490-559                 ...............................ILTADPEEETESPLQE--.---DSLHLQPHTP.....VP----------.-----.ASSESLELYPSSQTTERHqSHL.LSPSPTDIGSYMPTQMVSTA..
A0A1L8HQ75_XENLA/517-604             ......................ltsltpskq----------VVPLHTTAhGDAPGSQLQNQDS.....S-ILHLPLCHRL.SPIPT.VSSASLVHYHNSSSPENH.SHL.LSPSHNTIDSFISTQMASSS..
A0A1V4JRS9_PATFA/543-630             ..............................a-FTSDSETHTESGMHTPV.SQAPTIHLQNQDT.....T-IQHLQPGPRL.TPSPA.VSSSSLVLYQSSDSTNSH.TQL.LPSTHNAMETFISTQMASST..
A0A1S3WE68_ERIEU/539-626             ...............................VFTSEAEASSESGLPTPV.SQATTIHIPNQDP.....GGIQHLQP-HRL.SASPS.VSSSSLVLYQSSDSTNGH.SHL.LPSSHSVIETFISTQMASSS..
G3HI63_CRIGR/579-667                 ...............................VFTSDTEGSSEPGLHEPS.SPATTIHIPSQDP.....SSIQHLQPAHRL.STSPT.VSSSSLVLYQSSDSTNGH.SHL.LPSNHGVIETFISTQMASSS..
A0A1U7QQX3_MESAU/541-629             ...............................VFTSDTEASSEPGLHEPS.SPATTIHIPSQDP.....SSIQHLQPAHRL.STSPT.VSSSSLVLYQSSDSTNGH.SHL.LPSNHGVIETFISTQMASSS..
A0A1U7R9V2_ALLSI/546-633             ...............................VFTSDSENHTESGIHTPV.SQTQTIHLQNQDT.....T-IQHLQPGPRL.TSSPA.ASSSSLVLYQSSDSTNSH.SHL.LPSTHSVIETFISAQMASST..
G3TJQ6_LOXAF/542-630                 ...............................VFTSDTEVSSESGLHTSV.SQATTIHIPSQDP.....AGIQHLQPAHRL.STSPT.VSSSSLVLYQSSDSTNSH.SHL.LPTNHSVIETFISTQMASSS..
I3JYX6_ORENI/489-558                 ...............................ILTTDPDEQEDAPLQE--.---DSLNMQPHSP.....AP----------.-----.VSSESLELYPSSQATESHqSHL.LSPSPTEISSYIPAQMVSTA..
H2NIW9_PONAB/258-346                 ...............................VFTSDTEASSESGLHTPA.SQATTLHVPSQDP.....AGIQHLQPAHRL.SASPT.VSSSSLVLYQSSDSSNGH.SHL.LPSNHSVIETFISTQMASSS..
H2UWZ0_TAKRU/487-555                 ...............................ILSADQEDHTDSPVHE--.---DSLQLQPNTP.....VP----------.-----.ASSESLELYPPSQPSDSHqSHL.LSPSPSDI-SYIPAQMASTA..
#=GC seq_cons                        ...............................VFTSDoEssoESGLHTPs.SQAsTlHl.sQDP.....usIQHLQPuHRL.SuSPo.VSSSSLVLYQSSDSoNuH.SHL.LPSsHSVIETFISTQMASSS..
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