GenomeNet

Database: Pfam
Entry: HNH
LinkDB: HNH
Original site: HNH 
#=GF ID   HNH
#=GF AC   PF01844.23
#=GF DE   HNH endonuclease
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   [1]
#=GF GA   21.40 21.40;
#=GF TC   21.40 21.40;
#=GF NC   21.30 21.30;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 45638612 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Homing_endonuclease
#=GF RC   Named family as HNH
#=GF RN   [1]
#=GF RM   7817395
#=GF RT   Amino acid sequence motif of group I intron endonucleases is
#=GF RT   conserved in open reading frames of group II introns. 
#=GF RA   Shub DA, Goodrich-Blair H, Eddy SR; 
#=GF RL   Trends Biochem Sci 1994;19:402-404.
#=GF RC   Extended HNH family
#=GF RN   [2]
#=GF RM   9358175
#=GF RT   Statistical modeling and analysis of the LAGLIDADG family of
#=GF RT   site-specific endonucleases and identification of an intein that
#=GF RT   encodes a site-specific endonuclease of the HNH family. 
#=GF RA   Dalgaard JZ, Klar AJ, Moser MJ, Holley WR, Chatterjee A, Mian
#=GF RA   IS; 
#=GF RL   Nucleic Acids Res 1997;25:4626-4638.
#=GF RC   Named family as EX1HH-HX3H
#=GF RN   [3]
#=GF RM   7920259
#=GF RT   Self-splicing group I and group II introns encode homologous
#=GF RT   (putative) DNA endonucleases of a new family. 
#=GF RA   Gorbalenya AE; 
#=GF RL   Protein Sci 1994;3:1117-1120.
#=GF RN   [4]
#=GF RM   27131500
#=GF RT   Biochemical characterization of a thermostable HNH endonuclease
#=GF RT   from deep-sea thermophilic bacteriophage GVE2.
#=GF RA   Zhang L, Huang Y, Xu D, Yang L, Qian K, Chang G, Gong Y, Zhou X,
#=GF RA   Ma K;
#=GF RL   Appl Microbiol Biotechnol. 2016;100:8003-8012.
#=GF DR   INTERPRO; IPR002711;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   His-Asn-His (HNH) proteins are a very common family of small
#=GF CC   nucleic acid-binding proteins that are generally associated with
#=GF CC   endonuclease activity [4].
#=GF SQ   10094
#=GS U7L529_9CORY/283-330        AC U7L529.1
#=GS A0A1W2EUS4_9RHOB/150-208    AC A0A1W2EUS4.1
#=GS A0A1Z4RZ28_9NOSO/23-70      AC A0A1Z4RZ28.1
#=GS S5YS18_9CAUD/32-74          AC S5YS18.1
#=GS L8MYY7_9CYAN/22-69          AC L8MYY7.1
#=GS C0ZWV1_RHOE4/341-381        AC C0ZWV1.1
#=GS Q2IH63_ANADE/274-313        AC Q2IH63.1
#=GS A0A1F8NSB9_9CHLR/685-733    AC A0A1F8NSB9.1
#=GS R9IQ43_9FIRM/554-600        AC R9IQ43.1
#=GS A0A1H6Z872_9PSED/56-104     AC A0A1H6Z872.1
#=GS A0A238W098_9RHOB/108-150    AC A0A238W098.1
#=GS A0A1C3P796_9ACTN/47-96      AC A0A1C3P796.1
#=GS I4VZE4_9GAMM/27-75          AC I4VZE4.1
#=GS A3IT25_9CYAN/517-563        AC A3IT25.1
#=GS A0A1H2WSX3_9FIRM/354-411    AC A0A1H2WSX3.1
#=GS R9R287_9CAUD/34-84          AC R9R287.1
#=GS A0A162QS69_9CLOT/525-572    AC A0A162QS69.1
#=GS K9R7L7_9CYAN/3-44           AC K9R7L7.1
#=GS A0A2G3D1X2_CAPCH/157-201    AC A0A2G3D1X2.1
#=GS A0A0U4JL97_9CAUD/33-77      AC A0A0U4JL97.1
#=GS A0A085U4E0_YERRU/27-75      AC A0A085U4E0.1
#=GS A0A1Z8XCX1_9PROT/8-50       AC A0A1Z8XCX1.1
#=GS A0A0F3PHP1_9RICK/328-374    AC A0A0F3PHP1.1
#=GS A0A1R4ESX2_9MICO/392-436    AC A0A1R4ESX2.1
#=GS A0A1V2ICR4_9ACTN/364-410    AC A0A1V2ICR4.1
#=GS A0A1R4FIE2_9MICO/575-619    AC A0A1R4FIE2.1
#=GS A0A1N6K0C4_9BRAD/28-75      AC A0A1N6K0C4.1
#=GS A0A1Z4Q2L5_9CYAN/539-585    AC A0A1Z4Q2L5.1
#=GS A3DFY5_CLOTH/65-111         AC A3DFY5.1
#=GS A0A0F7PP51_9RHIZ/62-107     AC A0A0F7PP51.1
#=GS S5T1T1_9CORY/331-376        AC S5T1T1.1
#=GS A0A238UPU0_9RHOB/35-79      AC A0A238UPU0.1
#=GS S3ZUV8_9ACTN/87-128         AC S3ZUV8.1
#=GS A0A1Q2CE84_9ACTN/367-408    AC A0A1Q2CE84.1
#=GS K9UPS1_CHAP6/21-68          AC K9UPS1.1
#=GS A0A0M2KI54_9GAMM/21-66      AC A0A0M2KI54.1
#=GS A0A160T1H3_9CHLR/226-276    AC A0A160T1H3.2
#=GS A0A138ATY7_9ACTN/253-307    AC A0A138ATY7.1
#=GS A3IV33_9CYAN/524-570        AC A3IV33.1
#=GS A0A1J4ZYY0_9CHLR/22-69      AC A0A1J4ZYY0.1
#=GS D4S857_9FIRM/57-101         AC D4S857.1
#=GS W5XQN9_9CORY/276-318        AC W5XQN9.1
#=GS A0A1W9X1K3_9DELT/26-73      AC A0A1W9X1K3.1
#=GS A0A0U1NQJ4_9BACI/34-91      AC A0A0U1NQJ4.1
#=GS A0A177QX40_9PLAN/106-151    AC A0A177QX40.1
#=GS A0A1Z4LCL6_NOSLI/173-229    AC A0A1Z4LCL6.1
#=GS A0A1I5M129_9BACT/60-109     AC A0A1I5M129.1
#=GS A0A1M5G5D7_9ACTN/23-68      AC A0A1M5G5D7.1
#=GS A0A1M7KKC7_9RHOB/54-101     AC A0A1M7KKC7.1
#=GS D1Y7F2_9BACT/19-78          AC D1Y7F2.1
#=GS A0A2A2I8T7_9BACI/275-324    AC A0A2A2I8T7.1
#=GS A0A1H1T6Q5_9CORY/271-310    AC A0A1H1T6Q5.1
#=GS A0A075U614_9LACT/31-79      AC A0A075U614.1
#=GS F9QCK9_9MOLU/300-347        AC F9QCK9.1
#=GS Q2YCU1_NITMU/59-107         AC Q2YCU1.1
#=GS A0A1A6KPP8_9VIBR/33-81      AC A0A1A6KPP8.1
#=GS K6X2Y8_9ACTN/70-128         AC K6X2Y8.1
#=GS A0A1A2CUI7_9MYCO/499-541    AC A0A1A2CUI7.1
#=GS E9T560_RHOHA/348-395        AC E9T560.1
#=GS A0A0E3S4S0_9EURY/73-118     AC A0A0E3S4S0.1
#=GS W8VXE4_9FLAO/97-154         AC W8VXE4.1
#=GS H6WZK7_9VIRU/48-94          AC H6WZK7.1
#=GS W0HT50_9GAMM/27-75          AC W0HT50.1
#=GS A0A0M4LP62_9MICC/30-72      AC A0A0M4LP62.1
#=GS A0A1I5DGI3_9BURK/223-273    AC A0A1I5DGI3.1
#=GS A0A1Z4V9J8_9CYAN/21-68      AC A0A1Z4V9J8.1
#=GS A0A1M7Y746_9DELT/184-227    AC A0A1M7Y746.1
#=GS A0A1E5QPZ7_9CYAN/3-48       AC A0A1E5QPZ7.1
#=GS A0A126ZVH4_9MICC/364-421    AC A0A126ZVH4.1
#=GS A0A0N1LLW2_9PROT/48-94      AC A0A0N1LLW2.1
#=GS A0A1F0QUR8_9ACTO/563-609    AC A0A1F0QUR8.1
#=GS A0A2A3I1Y0_9ACTN/109-161    AC A0A2A3I1Y0.1
#=GS A0A0E0LKL3_ORYPU/962-1007   AC A0A0E0LKL3.1
#=GS A0A068NSL2_9BACT/264-315    AC A0A068NSL2.1
#=GS A0A1G6HE40_9ACTN/363-405    AC A0A1G6HE40.1
#=GS A0A1G8HSS8_9NOCA/373-418    AC A0A1G8HSS8.1
#=GS A0A0A2TSM8_9FIRM/66-112     AC A0A0A2TSM8.1
#=GS E5XNB6_9ACTN/112-159        AC E5XNB6.1
#=GS A0A1U9KA90_9BACL/172-228    AC A0A1U9KA90.1
#=GS F2RFX4_STRVP/28-74          AC F2RFX4.1
#=GS A0A1G5QTA9_9MICC/384-427    AC A0A1G5QTA9.1
#=GS A0A2A2Z3R2_9ACTN/25-82      AC A0A2A2Z3R2.1
#=GS R4LW32_MYCTX/309-353        AC R4LW32.1
#=GS A0A1T5K341_9CLOT/62-110     AC A0A1T5K341.1
#=GS B3EQR3_CHLPB/315-360        AC B3EQR3.1
#=GS A0A1Z4RN67_9CHRO/526-572    AC A0A1Z4RN67.1
#=GS C0XT26_CORLD/318-364        AC C0XT26.1
#=GS A0A1E2WM39_9NOSO/505-551    AC A0A1E2WM39.1
#=GS V9VP38_9RHOB/33-81          AC V9VP38.1
#=GS A0A0M0EWF2_9BACI/69-119     AC A0A0M0EWF2.1
#=GS A0A1G8IJF4_9BACI/32-80      AC A0A1G8IJF4.1
#=GS A0A1W1VIR4_9DEIO/180-225    AC A0A1W1VIR4.1
#=GS A0A139XB73_9CYAN/22-69      AC A0A139XB73.1
#=GS A0A231HL43_9BURK/64-110     AC A0A231HL43.1
#=GS A0YYD3_LYNSP/511-559        AC A0YYD3.1
#=GS F0VIP5_NEOCL/3576-3623      AC F0VIP5.1
#=GS U5QGJ5_9CYAN/21-68          AC U5QGJ5.1
#=GS A0A0Q5B895_9MICO/50-95      AC A0A0Q5B895.1
#=GS A0A0N0KW48_9MICO/83-124     AC A0A0N0KW48.1
#=GS A0A260BTD3_9NOCA/314-358    AC A0A260BTD3.1
#=GS A0A1N7JI71_9CORY/306-352    AC A0A1N7JI71.1
#=GS A0A285BG02_9FIRM/554-599    AC A0A285BG02.1
#=GS A0A1Z4UZU3_9CYAN/16-63      AC A0A1Z4UZU3.1
#=GS A0A085JGC4_9GAMM/27-75      AC A0A085JGC4.1
#=GS A0A158EMZ9_9BURK/507-550    AC A0A158EMZ9.1
#=GS R7WIA8_9NOCA/361-406        AC R7WIA8.1
#=GS H2TZC7_TAKRU/541-586        AC H2TZC7.1
#=GS A0A291GSA5_9MICO/384-427    AC A0A291GSA5.1
#=GS A0A1I5TDC5_9PROT/31-77      AC A0A1I5TDC5.1
#=GS A0A1R0FAB5_9RHIZ/241-299    AC A0A1R0FAB5.1
#=GS A0A1N7HAE9_9ACTN/54-101     AC A0A1N7HAE9.1
#=GS A0A0D7CKZ7_9ACTN/131-186    AC A0A0D7CKZ7.1
#=GS A0A176FEN8_9RHOB/6-50       AC A0A176FEN8.1
#=GS L7KJQ7_9ACTN/325-368        AC L7KJQ7.1
#=GS A0A1Y0IFP8_9GAMM/150-201    AC A0A1Y0IFP8.1
#=GS V7CJZ0_PHAVU/1055-1099      AC V7CJZ0.1
#=GS M3GGL0_LEPBO/80-135         AC M3GGL0.1
#=GS A0A1E5LC55_9BACI/10-51      AC A0A1E5LC55.1
#=GS B0C2Z7_ACAM1/60-106         AC B0C2Z7.1
#=GS A0A1M3K259_9CHLR/682-730    AC A0A1M3K259.1
#=GS A0A0Q6Z4H0_9BRAD/25-73      AC A0A0Q6Z4H0.1
#=GS K9YYW8_DACSA/498-544        AC K9YYW8.1
#=GS A0A0E0EE13_9ORYZ/1058-1102  AC A0A0E0EE13.1
#=GS A0A0G0E890_9BACT/336-389    AC A0A0G0E890.1
#=GS A0A081XU84_STRTO/170-224    AC A0A081XU84.1
#=GS J3GT75_9PSED/39-87          AC J3GT75.1
#=GS I7H4N4_9HELI/3-43           AC I7H4N4.1
#=GS A0A267MR05_9CLOT/206-257    AC A0A267MR05.1
#=GS A9BU78_DELAS/259-310        AC A9BU78.1
#=GS R9ZW62_9CAUD/32-74          AC R9ZW62.1
#=GS D2S1X8_HALTV/13-64          AC D2S1X8.1
#=GS A0A1J4TZA6_9BACT/318-368    AC A0A1J4TZA6.1
#=GS I4EG12_9CHLR/116-163        AC I4EG12.1
#=GS I3K1Z0_ORENI/1075-1119      AC I3K1Z0.1
#=GS K9NNN6_9PSED/44-88          AC K9NNN6.1
#=GS A0A0V2F4X3_CAUVI/8-58       AC A0A0V2F4X3.1
#=GS A0A158EEK2_9BURK/288-334    AC A0A158EEK2.1
#=GS A0A1E7K3A9_9ACTN/84-125     AC A0A1E7K3A9.1
#=GS A0A1G2QCD9_9BACT/134-176    AC A0A1G2QCD9.1
#=GS Q10VM8_TRIEI/1-33           AC Q10VM8.1
#=GS R5IS90_9CLOT/65-111         AC R5IS90.1
#=GS R7N9B8_9FIRM/156-213        AC R7N9B8.1
#=GS A0A1N6GRI4_9RHOB/181-237    AC A0A1N6GRI4.1
#=GS B3E309_GEOLS/47-95          AC B3E309.1
#=GS A0A1I2DVJ4_9FIRM/78-123     AC A0A1I2DVJ4.1
#=GS C0ZXE1_RHOE4/313-358        AC C0ZXE1.1
#=GS A0A1Y2L9Z2_9PROT/255-311    AC A0A1Y2L9Z2.1
#=GS A0A024H146_9MICC/187-242    AC A0A024H146.1
#=GS S8CRY6_9LAMI/748-793        AC S8CRY6.1
#=GS A0A222YY45_9CAUD/31-92      AC A0A222YY45.1
#=GS A7HAH6_ANADF/304-353        AC A7HAH6.1
#=GS A0A117KGZ5_9ACTN/342-391    AC A0A117KGZ5.1
#=GS R5SW00_9CLOT/329-387        AC R5SW00.1
#=GS E0UB34_CYAP2/509-555        AC E0UB34.1
#=GS V8D242_9ACTN/324-367        AC V8D242.1
#=GS C4LKJ8_CORK4/22-69          AC C4LKJ8.1
#=GS A0A0A6VP49_9MICC/33-78      AC A0A0A6VP49.1
#=GS A0A2I4BEG6_9TELE/909-954    AC A0A2I4BEG6.1
#=GS A0A0H0ZS22_9MICC/9-61       AC A0A0H0ZS22.1
#=GS A0A1I0FF39_9CLOT/38-86      AC A0A1I0FF39.1
#=GS A0A160DE31_9CAUD/23-74      AC A0A160DE31.1
#=GS H6MZN7_GORPV/344-387        AC H6MZN7.1
#=GS Q1JWV7_DESA6/50-98          AC Q1JWV7.1
#=GS A0A1M7XXC8_9FIRM/66-112     AC A0A1M7XXC8.1
#=GS S4XZ67_SORCE/27-79          AC S4XZ67.1
#=GS A0ZKA1_NODSP/20-66          AC A0ZKA1.1
#=GS Q4C6E0_CROWT/94-140         AC Q4C6E0.1
#=GS A0A081N315_9GAMM/69-115     AC A0A081N315.1
#=GS Q3J216_RHOS4/35-82          AC Q3J216.1
#=GS A0A074U2E1_9RHOB/25-72      AC A0A074U2E1.1
#=GS A0A1Q1FJB3_9EURY/200-256    AC A0A1Q1FJB3.1
#=GS Q24RY4_DESHY/22-66          AC Q24RY4.1
#=GS A0A238XDS3_HALVU/56-106     AC A0A238XDS3.1
#=GS A0A1C7IG64_9FIRM/60-108     AC A0A1C7IG64.1
#=GS Q3EQP7_BACTI/101-149        AC Q3EQP7.1
#=GS D5A3A3_ARTPN/336-382        AC D5A3A3.1
#=GS A0A0K1LL59_9CAUD/41-89      AC A0A0K1LL59.1
#=GS A0A2A2EQV2_9GAMM/54-111     AC A0A2A2EQV2.1
#=GS D9R5E9_CLOSW/27-72          AC D9R5E9.1
#=GS A0A0D5AJB3_9NOCA/386-431    AC A0A0D5AJB3.1
#=GS A0A1P8NBV6_9MICO/70-117     AC A0A1P8NBV6.1
#=GS A0A0B0QQK1_APHFL/20-67      AC A0A0B0QQK1.1
#=GS A0A1N7GVW2_9ACTN/695-741    AC A0A1N7GVW2.1
#=GS V6JWS5_STRRC/70-114         AC V6JWS5.1
#=GS W6T8G4_9LACO/90-137         AC W6T8G4.1
#=GS D4ZMX1_ARTPN/152-197        AC D4ZMX1.1
#=GS W6M3X0_9GAMM/252-304        AC W6M3X0.1
#=GS A0A1L7D6A7_9CORY/242-288    AC A0A1L7D6A7.1
#=GS A0A1H4LAW3_9MICO/356-403    AC A0A1H4LAW3.1
#=GS H5TEE5_9ALTE/30-78          AC H5TEE5.1
#=GS W1TUR7_9ACTO/27-78          AC W1TUR7.1
#=GS A0A1A0KG33_9MYCO/308-352    AC A0A1A0KG33.1
#=GS R9IVW8_9FIRM/65-111         AC R9IVW8.1
#=GS R5BKF2_9FIRM/31-72          AC R5BKF2.1
#=GS A0A1U8C8S5_MESAU/648-690    AC A0A1U8C8S5.1
#=GS L8TQD1_9MICC/339-384        AC L8TQD1.1
#=GS A0A212RU80_9CHLR/95-138     AC A0A212RU80.1
#=GS C3PJT8_CORA7/262-306        AC C3PJT8.1
#=GS R6BBL4_9CLOT/594-641        AC R6BBL4.1
#=GS A0A2D0KAN0_9GAMM/66-112     AC A0A2D0KAN0.1
#=GS N1ZS60_9CLOT/35-87          AC N1ZS60.1
#=GS A0A1Q9S354_9PSEU/281-327    AC A0A1Q9S354.1
#=GS C1A250_RHOE4/28-81          AC C1A250.1
#=GS A0A024HJ14_PSEKB/34-82      AC A0A024HJ14.1
#=GS I0GPZ4_SELRL/30-77          AC I0GPZ4.1
#=GS A0A1P8VVU5_9VIRU/40-90      AC A0A1P8VVU5.1
#=GS A0A1A2GCD7_9MYCO/306-351    AC A0A1A2GCD7.1
#=GS A0A1U9YYM5_9RHIZ/66-109     AC A0A1U9YYM5.1
#=GS R7ZFP0_LYSSH/519-566        AC R7ZFP0.1
#=GS V4TQC1_9ROSI/64-111         AC V4TQC1.1
#=GS A0A1Z9CVT7_9PROT/63-98      AC A0A1Z9CVT7.1
#=GS K9ZNE2_ANACC/19-67          AC K9ZNE2.1
#=GS X8ABE6_MYCAV/307-353        AC X8ABE6.1
#=GS V4B492_LOTGI/978-1023       AC V4B492.1
#=GS R4JX48_CLOPA/43-91          AC R4JX48.1
#=GS A0A0L0WAC4_CLOPU/188-240    AC A0A0L0WAC4.1
#=GS A0A0S9CP22_9MICC/82-123     AC A0A0S9CP22.1
#=GS C3X7W4_OXAFO/53-101         AC C3X7W4.1
#=GS K9VTB4_9CYAN/499-545        AC K9VTB4.1
#=GS B1XLL3_SYNP2/426-471        AC B1XLL3.1
#=GS A0A0A0YV65_9CAUD/41-91      AC A0A0A0YV65.1
#=GS A0A1Q3VMZ7_9PROT/40-88      AC A0A1Q3VMZ7.1
#=GS A0A2A3XZE9_9MICC/391-434    AC A0A2A3XZE9.1
#=GS A0A1H1ZQS4_9ACTN/379-424    AC A0A1H1ZQS4.1
#=GS A0A0E0GHE8_ORYNI/102-142    AC A0A0E0GHE8.1
#=GS A0A1A7KN08_9FLAO/21-68      AC A0A1A7KN08.1
#=GS W5XVI9_9CORY/81-123         AC W5XVI9.1
#=GS A0A0Q9KI49_9MICO/382-427    AC A0A0Q9KI49.1
#=GS A0A199AZ79_9ACTN/39-82      AC A0A199AZ79.1
#=GS A1B5C7_PARDP/34-78          AC A1B5C7.1
#=GS A0A151B7R0_9CLOT/72-120     AC A0A151B7R0.1
#=GS A0A0K8P689_IDESA/495-541    AC A0A0K8P689.1
#=GS A0A1V2S9E9_9BACI/26-73      AC A0A1V2S9E9.1
#=GS F8KSU8_HELBC/97-142         AC F8KSU8.1
#=GS A0A1G9V154_9ACTN/179-232    AC A0A1G9V154.1
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