#=GF ID Hemolysin_N
#=GF AC PF12563.11
#=GF DE Hemolytic toxin N terminal
#=GF AU Gavin OL;
#=GF SE Prosite
#=GF GA 22.50 22.50;
#=GF TC 22.50 67.70;
#=GF NC 22.40 22.20;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Family
#=GF WK Hemolysin
#=GF CL CL0636
#=GF RN [1]
#=GF RM 12479411
#=GF RT Purification, characterization and molecular cloning of Vibrio
#=GF RT fluvialis hemolysin.
#=GF RA Han JH, Lee JH, Choi YH, Park JH, Choi TJ, Kong IS;
#=GF RL Biochim Biophys Acta. 2002;1599:106-114.
#=GF DR INTERPRO; IPR022220;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC This domain family is found in bacteria, and is approximately
#=GF CC 190 amino acids in length. The family is found in association
#=GF CC with Pfam:PF07968, Pfam:PF00652. This family is a bacterial
#=GF CC virulence factor - hemolysin - which forms pores in erythrocytes
#=GF CC and causes them to lyse.
#=GF SQ 12
#=GS A0A2T3N0F1_9GAMM/1-182 AC A0A2T3N0F1.1
#=GS A0A0Q2MKS2_VIBFU/1-163 AC A0A0Q2MKS2.1
#=GS D0YYQ7_PHODD/3-185 AC D0YYQ7.1
#=GS A0A4P9VNA6_9GAMM/8-198 AC A0A4P9VNA6.1
#=GS E3BMX3_9VIBR/31-194 AC E3BMX3.1
#=GS C9P680_VIBME/3-187 AC C9P680.1
#=GS A0A178K7H8_9GAMM/6-195 AC A0A178K7H8.1
#=GS HLY1_AERHH/9-196 AC P55870.2
#=GS A0A090ICS3_9GAMM/1-185 AC A0A090ICS3.1
#=GS A0A233HNU4_9VIBR/2-188 AC A0A233HNU4.1
#=GS HLYA_VIBCH/3-187 AC P09545.2
#=GS HLYA_VIBCH/3-187 DR PDB; 1XEZ A; 21-162;
#=GS HLYA_VIBCH/3-187 DR PDB; 3O44 I; 136-162;
#=GS HLYA_VIBCH/3-187 DR PDB; 3O44 H; 136-162;
#=GS HLYA_VIBCH/3-187 DR PDB; 3O44 N; 136-162;
#=GS HLYA_VIBCH/3-187 DR PDB; 3O44 E; 136-162;
#=GS HLYA_VIBCH/3-187 DR PDB; 3O44 A; 136-162;
#=GS HLYA_VIBCH/3-187 DR PDB; 3O44 M; 136-162;
#=GS HLYA_VIBCH/3-187 DR PDB; 3O44 D; 136-162;
#=GS HLYA_VIBCH/3-187 DR PDB; 3O44 L; 136-162;
#=GS HLYA_VIBCH/3-187 DR PDB; 3O44 G; 136-162;
#=GS HLYA_VIBCH/3-187 DR PDB; 3O44 J; 136-162;
#=GS HLYA_VIBCH/3-187 DR PDB; 3O44 B; 136-162;
#=GS HLYA_VIBCH/3-187 DR PDB; 3O44 F; 136-162;
#=GS HLYA_VIBCH/3-187 DR PDB; 3O44 K; 136-162;
#=GS HLYA_VIBCH/3-187 DR PDB; 3O44 C; 136-162;
#=GS D0Z5B0_PHODD/3-185 AC D0Z5B0.1
A0A2T3N0F1_9GAMM/1-182 ...................mirktn------LITLAM.MGLMATTTWAAGIDEPA.G.SAINMLSSLQDVSSVNYINAEYLLDNDVMPLSLT--EIKTQVLNEDKRYFIDFSNIATEVDKNTAKSKLRHSMGIGLTGDMIIISAYKGELMFSQLDGEDDPN----I.TLLEGEPKRASRNKRSTTQLSNPD.......NSIPNVAFYLHANRRISDRECNL---twn
A0A0Q2MKS2_VIBFU/1-163 ........................m------------.----------ADIHDPV.G.EAVSILSQVSDSSQINYFNAQYWQGNDSDMPTLA--QLRQFVVQEKQRILMDFSQIENNEERAVMQALFRQQYGMSFASRFILVTEHKGELLFTPFDVADDVN----P.ALLEAPAAKRVRRSLSDTQRVSGGe.....aNTLPHVAFYINVNRAISDEECTFDNS...
D0YYQ7_PHODD/3-185 ..................irklysc--------ILLG.LSSLSASAIADVDNYST.GaDVISILSSVQNPDRIVYVNMK-----QEEISTY--NRILEDIIYNDKQYIFDLS-FDNNEEKEKLQKKFKDLMGVKFDSNFIVVTGYKNQLMYTPIADANDRMVSVLD.HEARSNDISKYPMALALRSGNATSd....qsISLPHVSFYLNVNKEITDQECTFRNS...
A0A4P9VNA6_9GAMM/8-198 ...mlccalgslastcfsynnsynq------------.-------------HNYS.P.SATLILQNTTLNNQVKYINFSSITEEKLDYKNFK--IIENDILENNTIYWIDFTQSISQNGEHLNHEKVKKLFGIVYQEDMLLISSYKGKLLYTPFNSANSTLFSQLTnQLLNNSHSSRKRVARDVTTNTSKEstvsddkKAPPNVSFYINVFRPITDEECTFKRS...
E3BMX3_9VIBR/31-194 ............avfhhfpvfahpm------------.---------------QS.D.TALLIMQSVYSPSNINYINLNEVSD-DALEKSLP--AVNDNVINENKKYLLDFSQLEDNDKIERYQKQIQSRIGMSIVTPFLAITNYQGSMLFTPISDSLDPQIQRLN.EDN--SRPSSSRKRRSVQKISP--.......---PKLSFYVSLNKQFSESDCLFPR-v..
C9P680_VIBME/3-187 ........................i--YNNKTIALAAiLSGLVWNTAYADVQQPQ.G.VAVEMLSTLQDDSQVSYLNAAELLVEEGTVPTLS--DVRDSVLRQHQRYLIDFSNISDEQGKTQAKALLRGQLGVALSSDFWLITEHKGELLFTGLDDENDPS----I.QLLEAQPVTYSRQRRSIDSRTNATs....eaNSLPHVAFYVNVHRPISDEECTFKNS...
A0A178K7H8_9GAMM/6-195 kfaltplaailfscsvqasqyheae------------.---------AFSMYEPV.G.DAVNIVSRINDPEGLRYINAKYWLNDNDDL-SLGFDRVDQIVKDEGGRYLIDFTEIFDYSDKIKAKKLFSRIFGISFDADYVAITKYKESLLFTELTGSGDQN-VTIL.NRTYEPMALALMSDDPYQPLVPKQ.......IPVPNVAFYVNASRQISDQDCKI---ewn
HLY1_AERHH/9-196 .........................FITQAPTLSLLA.LALLAGSVQAEDIGERT.D.QGTAMLASLQSEQGLIYLNADVWLKRQGATPLMTRDQLRERVLARGERLFIDFSAVTDQSERQQTRKAMEQLAGISFDADWVLVSGYKGELLFTPLGGVDDPAFYQVM.ERVESLEGQGKRHKRSLTQPPAAE.......AGLPHVAFYLNVNRKISDAECTFPRS...
A0A090ICS3_9GAMM/1-185 ................mlstlllas------------.SAVLSQPF--EVTNNMT.D.GAVNIVKQLTNSQNVVYFNAASLLKEGGELQKLTLQEIEQEVVGNKNKYLLDFSSLTSPEQKQRALDKVSKITGISFEQDFLVISAFKGSLLYTPVSSPEDPNVSALE.TANITTLPAPLTIQKRQGSPQAIQk.....sQGSPALSFYVSANRPISDGECSFS--sg.
A0A233HNU4_9VIBR/2-188 .......................si--NRRKALSAIAiMSGLVWNTAQADVNQPQ.G.LAIEMFSELQDDSQINYFNASYWLQGEVEPPTLM--QIRDDVLNQHMRYFVDFSTIEGESQKTEAKALLRKKLGLAFASDFLIISEHKGELLFTPLDDENDAN----I.RLLEAAPIAHSRQRRSTASMVSNSgs...etNSLPHVAFYLNVNRPITDSECTFKNS...
HLYA_VIBCH/3-187 .......................kl---NRCAIAIFTiLSAISSPTLLANINEPS.G.EAADIISQVADSHAIKYYNAADWQAEDNALPSLA--ELRDLVINQQKRVLVDFSQISDAEGQAEMQAQFRKAYGVGFANQFIVITEHKGELLFTPFDQAEEVD----P.QLLEAPRTARLLARSGFASPAPANs....etNTLPHVAFYISVNRAISDEECTFNNS...
#=GR HLYA_VIBCH/3-187 SS .......................XX---XXXXXXXXXXXXXXXXXXXXXXXXXXX.X.XXXXXXXXXXXXXXEEEEEGGGGGXXXXXXXXHH--HHHHHHTTSXXEEEEEXTTXXSHHHHHHHHHHHHHHHSXBXXSSEEEEEEETTEEEEEEESSXXXXX----X.XXXXXXXXXXXXXXXXXXXXXXXXX....XTTSS-EEEEEEEEEEE--TTTTEEES-...
D0Z5B0_PHODD/3-185 ..................irklysc--------ILLG.LSSLSASAIAEVDNYSTpA.DVVSILSSVKNPDRIVYINMKQ-----EE--LSTYDSILEDIINNDKQYIFDLSFDSD-EEKANIQKKFKDLMGVKFDSNFIVVTGYKNQLMYTPISDTNDRMISILD.HEAKSDDISKFPRALALSSGKVASd....qsISLPHVSFYLNVNKEITDQECTFRNS...
#=GC SS_cons .......................XX---XXXXXXXXXXXXXXXXXXXXXXXXXXX.X.XXXXXXXXXXXXXXEEEEEGGGGGXXXXXXXXHH--HHHHHHTTSXXEEEEEXTTXXSHHHHHHHHHHHHHHHSXBXXSSEEEEEEETTEEEEEEESSXXXXX----X.XXXXXXXXXXXXXXXXXXXXXXXXX....XTTSS-EEEEEEEEEEE--TTTTEEES-...
#=GC seq_cons .......................s...............u.hs.sh..tshppss.u.sAlsIlSplpsssplsYlNAp.h.tppsph.oLs..plcppVlsppp+YllDFSplpsppp+pphppth+chhGluFsucFllIotaKGpLLFTPlssssDss......phhcus.ssthpppcuhsshssspt.....ttulP+VuFYlNVNRtISDpECTFppS...
//
