GenomeNet

Database: Pfam
Entry: Hemolysin_N
LinkDB: Hemolysin_N
Original site: Hemolysin_N 
#=GF ID   Hemolysin_N
#=GF AC   PF12563.11
#=GF DE   Hemolytic toxin N terminal
#=GF AU   Gavin OL;
#=GF SE   Prosite
#=GF GA   22.50 22.50;
#=GF TC   22.50 67.70;
#=GF NC   22.40 22.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Hemolysin
#=GF CL   CL0636
#=GF RN   [1]
#=GF RM   12479411
#=GF RT   Purification, characterization and molecular cloning of Vibrio
#=GF RT   fluvialis hemolysin.
#=GF RA   Han JH, Lee JH, Choi YH, Park JH, Choi TJ, Kong IS;
#=GF RL   Biochim Biophys Acta. 2002;1599:106-114.
#=GF DR   INTERPRO; IPR022220;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This domain family is found in bacteria, and is approximately
#=GF CC   190 amino acids in length. The family is found in association
#=GF CC   with Pfam:PF07968, Pfam:PF00652. This family is a bacterial
#=GF CC   virulence factor - hemolysin - which forms pores in erythrocytes
#=GF CC   and causes them to lyse.
#=GF SQ   12
#=GS A0A2T3N0F1_9GAMM/1-182  AC A0A2T3N0F1.1
#=GS A0A0Q2MKS2_VIBFU/1-163  AC A0A0Q2MKS2.1
#=GS D0YYQ7_PHODD/3-185      AC D0YYQ7.1
#=GS A0A4P9VNA6_9GAMM/8-198  AC A0A4P9VNA6.1
#=GS E3BMX3_9VIBR/31-194     AC E3BMX3.1
#=GS C9P680_VIBME/3-187      AC C9P680.1
#=GS A0A178K7H8_9GAMM/6-195  AC A0A178K7H8.1
#=GS HLY1_AERHH/9-196        AC P55870.2
#=GS A0A090ICS3_9GAMM/1-185  AC A0A090ICS3.1
#=GS A0A233HNU4_9VIBR/2-188  AC A0A233HNU4.1
#=GS HLYA_VIBCH/3-187        AC P09545.2
#=GS HLYA_VIBCH/3-187        DR PDB; 1XEZ A; 21-162;
#=GS HLYA_VIBCH/3-187        DR PDB; 3O44 I; 136-162;
#=GS HLYA_VIBCH/3-187        DR PDB; 3O44 H; 136-162;
#=GS HLYA_VIBCH/3-187        DR PDB; 3O44 N; 136-162;
#=GS HLYA_VIBCH/3-187        DR PDB; 3O44 E; 136-162;
#=GS HLYA_VIBCH/3-187        DR PDB; 3O44 A; 136-162;
#=GS HLYA_VIBCH/3-187        DR PDB; 3O44 M; 136-162;
#=GS HLYA_VIBCH/3-187        DR PDB; 3O44 D; 136-162;
#=GS HLYA_VIBCH/3-187        DR PDB; 3O44 L; 136-162;
#=GS HLYA_VIBCH/3-187        DR PDB; 3O44 G; 136-162;
#=GS HLYA_VIBCH/3-187        DR PDB; 3O44 J; 136-162;
#=GS HLYA_VIBCH/3-187        DR PDB; 3O44 B; 136-162;
#=GS HLYA_VIBCH/3-187        DR PDB; 3O44 F; 136-162;
#=GS HLYA_VIBCH/3-187        DR PDB; 3O44 K; 136-162;
#=GS HLYA_VIBCH/3-187        DR PDB; 3O44 C; 136-162;
#=GS D0Z5B0_PHODD/3-185      AC D0Z5B0.1
A0A2T3N0F1_9GAMM/1-182             ...................mirktn------LITLAM.MGLMATTTWAAGIDEPA.G.SAINMLSSLQDVSSVNYINAEYLLDNDVMPLSLT--EIKTQVLNEDKRYFIDFSNIATEVDKNTAKSKLRHSMGIGLTGDMIIISAYKGELMFSQLDGEDDPN----I.TLLEGEPKRASRNKRSTTQLSNPD.......NSIPNVAFYLHANRRISDRECNL---twn
A0A0Q2MKS2_VIBFU/1-163             ........................m------------.----------ADIHDPV.G.EAVSILSQVSDSSQINYFNAQYWQGNDSDMPTLA--QLRQFVVQEKQRILMDFSQIENNEERAVMQALFRQQYGMSFASRFILVTEHKGELLFTPFDVADDVN----P.ALLEAPAAKRVRRSLSDTQRVSGGe.....aNTLPHVAFYINVNRAISDEECTFDNS...
D0YYQ7_PHODD/3-185                 ..................irklysc--------ILLG.LSSLSASAIADVDNYST.GaDVISILSSVQNPDRIVYVNMK-----QEEISTY--NRILEDIIYNDKQYIFDLS-FDNNEEKEKLQKKFKDLMGVKFDSNFIVVTGYKNQLMYTPIADANDRMVSVLD.HEARSNDISKYPMALALRSGNATSd....qsISLPHVSFYLNVNKEITDQECTFRNS...
A0A4P9VNA6_9GAMM/8-198             ...mlccalgslastcfsynnsynq------------.-------------HNYS.P.SATLILQNTTLNNQVKYINFSSITEEKLDYKNFK--IIENDILENNTIYWIDFTQSISQNGEHLNHEKVKKLFGIVYQEDMLLISSYKGKLLYTPFNSANSTLFSQLTnQLLNNSHSSRKRVARDVTTNTSKEstvsddkKAPPNVSFYINVFRPITDEECTFKRS...
E3BMX3_9VIBR/31-194                ............avfhhfpvfahpm------------.---------------QS.D.TALLIMQSVYSPSNINYINLNEVSD-DALEKSLP--AVNDNVINENKKYLLDFSQLEDNDKIERYQKQIQSRIGMSIVTPFLAITNYQGSMLFTPISDSLDPQIQRLN.EDN--SRPSSSRKRRSVQKISP--.......---PKLSFYVSLNKQFSESDCLFPR-v..
C9P680_VIBME/3-187                 ........................i--YNNKTIALAAiLSGLVWNTAYADVQQPQ.G.VAVEMLSTLQDDSQVSYLNAAELLVEEGTVPTLS--DVRDSVLRQHQRYLIDFSNISDEQGKTQAKALLRGQLGVALSSDFWLITEHKGELLFTGLDDENDPS----I.QLLEAQPVTYSRQRRSIDSRTNATs....eaNSLPHVAFYVNVHRPISDEECTFKNS...
A0A178K7H8_9GAMM/6-195             kfaltplaailfscsvqasqyheae------------.---------AFSMYEPV.G.DAVNIVSRINDPEGLRYINAKYWLNDNDDL-SLGFDRVDQIVKDEGGRYLIDFTEIFDYSDKIKAKKLFSRIFGISFDADYVAITKYKESLLFTELTGSGDQN-VTIL.NRTYEPMALALMSDDPYQPLVPKQ.......IPVPNVAFYVNASRQISDQDCKI---ewn
HLY1_AERHH/9-196                   .........................FITQAPTLSLLA.LALLAGSVQAEDIGERT.D.QGTAMLASLQSEQGLIYLNADVWLKRQGATPLMTRDQLRERVLARGERLFIDFSAVTDQSERQQTRKAMEQLAGISFDADWVLVSGYKGELLFTPLGGVDDPAFYQVM.ERVESLEGQGKRHKRSLTQPPAAE.......AGLPHVAFYLNVNRKISDAECTFPRS...
A0A090ICS3_9GAMM/1-185             ................mlstlllas------------.SAVLSQPF--EVTNNMT.D.GAVNIVKQLTNSQNVVYFNAASLLKEGGELQKLTLQEIEQEVVGNKNKYLLDFSSLTSPEQKQRALDKVSKITGISFEQDFLVISAFKGSLLYTPVSSPEDPNVSALE.TANITTLPAPLTIQKRQGSPQAIQk.....sQGSPALSFYVSANRPISDGECSFS--sg.
A0A233HNU4_9VIBR/2-188             .......................si--NRRKALSAIAiMSGLVWNTAQADVNQPQ.G.LAIEMFSELQDDSQINYFNASYWLQGEVEPPTLM--QIRDDVLNQHMRYFVDFSTIEGESQKTEAKALLRKKLGLAFASDFLIISEHKGELLFTPLDDENDAN----I.RLLEAAPIAHSRQRRSTASMVSNSgs...etNSLPHVAFYLNVNRPITDSECTFKNS...
HLYA_VIBCH/3-187                   .......................kl---NRCAIAIFTiLSAISSPTLLANINEPS.G.EAADIISQVADSHAIKYYNAADWQAEDNALPSLA--ELRDLVINQQKRVLVDFSQISDAEGQAEMQAQFRKAYGVGFANQFIVITEHKGELLFTPFDQAEEVD----P.QLLEAPRTARLLARSGFASPAPANs....etNTLPHVAFYISVNRAISDEECTFNNS...
#=GR HLYA_VIBCH/3-187        SS    .......................XX---XXXXXXXXXXXXXXXXXXXXXXXXXXX.X.XXXXXXXXXXXXXXEEEEEGGGGGXXXXXXXXHH--HHHHHHTTSXXEEEEEXTTXXSHHHHHHHHHHHHHHHSXBXXSSEEEEEEETTEEEEEEESSXXXXX----X.XXXXXXXXXXXXXXXXXXXXXXXXX....XTTSS-EEEEEEEEEEE--TTTTEEES-...
D0Z5B0_PHODD/3-185                 ..................irklysc--------ILLG.LSSLSASAIAEVDNYSTpA.DVVSILSSVKNPDRIVYINMKQ-----EE--LSTYDSILEDIINNDKQYIFDLSFDSD-EEKANIQKKFKDLMGVKFDSNFIVVTGYKNQLMYTPISDTNDRMISILD.HEAKSDDISKFPRALALSSGKVASd....qsISLPHVSFYLNVNKEITDQECTFRNS...
#=GC SS_cons                       .......................XX---XXXXXXXXXXXXXXXXXXXXXXXXXXX.X.XXXXXXXXXXXXXXEEEEEGGGGGXXXXXXXXHH--HHHHHHTTSXXEEEEEXTTXXSHHHHHHHHHHHHHHHSXBXXSSEEEEEEETTEEEEEEESSXXXXX----X.XXXXXXXXXXXXXXXXXXXXXXXXX....XTTSS-EEEEEEEEEEE--TTTTEEES-...
#=GC seq_cons                      .......................s...............u.hs.sh..tshppss.u.sAlsIlSplpsssplsYlNAp.h.tppsph.oLs..plcppVlsppp+YllDFSplpsppp+pphppth+chhGluFsucFllIotaKGpLLFTPlssssDss......phhcus.ssthpppcuhsshssspt.....ttulP+VuFYlNVNRtISDpECTFppS...
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