#=GF ID Hemolysin_N
#=GF AC PF12563.13
#=GF DE Hemolytic toxin N terminal
#=GF AU Gavin OL;
#=GF SE Prosite
#=GF GA 22.50 22.50;
#=GF TC 22.80 38.60;
#=GF NC 22.40 22.00;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -E 1000 -Z 81514348 HMM pfamseq
#=GF TP Family
#=GF WK Hemolysin
#=GF CL CL0636
#=GF RN [1]
#=GF RM 12479411
#=GF RT Purification, characterization and molecular cloning of Vibrio
#=GF RT fluvialis hemolysin.
#=GF RA Han JH, Lee JH, Choi YH, Park JH, Choi TJ, Kong IS;
#=GF RL Biochim Biophys Acta. 2002;1599:106-114.
#=GF DR INTERPRO; IPR022220;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC This domain family is found in bacteria, and is approximately
#=GF CC 190 amino acids in length. The family is found in association
#=GF CC with Pfam:PF07968, Pfam:PF00652. This family is a bacterial
#=GF CC virulence factor - hemolysin - which forms pores in erythrocytes
#=GF CC and causes them to lyse.
#=GF SQ 15
#=GS A0A5P9CS85_9VIBR/2-182 AC A0A5P9CS85.1
#=GS A0A0M9F8D2_PHOLD/4-192 AC A0A0M9F8D2.1
#=GS A0A4P9VNA6_9GAMM/8-198 AC A0A4P9VNA6.1
#=GS A0A1C3J2L0_9VIBR/7-185 AC A0A1C3J2L0.1
#=GS A0A2T3N0F1_9GAMM/1-182 AC A0A2T3N0F1.1
#=GS A0A0N0DJB1_PHOLD/2-194 AC A0A0N0DJB1.1
#=GS D0YYQ7_PHODD/4-185 AC D0YYQ7.1
#=GS HLYA_VIBCH/3-187 AC P09545.2
#=GS HLYA_VIBCH/3-187 DR PDB; 3O44 K; 136-162;
#=GS HLYA_VIBCH/3-187 DR PDB; 3O44 A; 136-162;
#=GS HLYA_VIBCH/3-187 DR PDB; 7YL9 N; 136-162;
#=GS HLYA_VIBCH/3-187 DR PDB; 7YL9 L; 136-162;
#=GS HLYA_VIBCH/3-187 DR PDB; 3O44 F; 136-162;
#=GS HLYA_VIBCH/3-187 DR PDB; 3O44 M; 136-162;
#=GS HLYA_VIBCH/3-187 DR PDB; 7YL9 H; 136-162;
#=GS HLYA_VIBCH/3-187 DR PDB; 1XEZ A; 21-162;
#=GS HLYA_VIBCH/3-187 DR PDB; 7YL9 K; 136-162;
#=GS HLYA_VIBCH/3-187 DR PDB; 3O44 E; 136-162;
#=GS HLYA_VIBCH/3-187 DR PDB; 3O44 C; 136-162;
#=GS HLYA_VIBCH/3-187 DR PDB; 3O44 I; 136-162;
#=GS HLYA_VIBCH/3-187 DR PDB; 7YL9 I; 136-162;
#=GS HLYA_VIBCH/3-187 DR PDB; 3O44 H; 136-162;
#=GS HLYA_VIBCH/3-187 DR PDB; 3O44 G; 136-162;
#=GS HLYA_VIBCH/3-187 DR PDB; 7YL9 M; 136-162;
#=GS HLYA_VIBCH/3-187 DR PDB; 7YL9 J; 136-162;
#=GS HLYA_VIBCH/3-187 DR PDB; 3O44 D; 136-162;
#=GS HLYA_VIBCH/3-187 DR PDB; 3O44 L; 136-162;
#=GS HLYA_VIBCH/3-187 DR PDB; 3O44 B; 136-162;
#=GS HLYA_VIBCH/3-187 DR PDB; 3O44 J; 136-162;
#=GS HLYA_VIBCH/3-187 DR PDB; 3O44 N; 136-162;
#=GS D0Z5B0_PHODD/4-185 AC D0Z5B0.1
#=GS E3BMX3_9VIBR/30-194 AC E3BMX3.1
#=GS HLY1_AERHH/9-196 AC P55870.2
#=GS A0A0N0V990_PHOLD/4-186 AC A0A0N0V990.1
#=GS A0A0M9F8E7_PHOLD/3-194 AC A0A0M9F8E7.1
#=GS A0A178K7H8_9GAMM/7-195 AC A0A178K7H8.1
#=GS A0A0Q2MKS2_VIBFU/1-163 AC A0A0Q2MKS2.1
A0A5P9CS85_9VIBR/2-182 ....................vlnk----KRTLIAIAIASCMAWNTATATINEPQ.G.VSVEILSSLQNSSKVAYINASYWL....NGE....VEPPSMT-..-TIRDNVLKLERRYLIDFTAIEDPSQKEEAKKLLSNKTGLSFTSDFLVITPHKGELLYTPLVDENDPN----K.FELETPLISEL.RDGS-----ESVNS....DASTIPHVAFYLRVNRPITDQECTFDKS....
A0A0M9F8D2_PHOLD/4-192 .................frsvkvv-------ISLII-IGLCCSSALAYN-EQPQ.G.LAANMLSQLQDSSHVDYINVGNWLidngEEN....NEKSSLYL..EKIATNVLKNNKRVFVDFTTIEDESKKDKAKQFFAQQIGVSFPENYLVITKHKNELMFAPIEGIDDPS----L.KLLDVHEQEKK.RFKRGVNKDSS-KS....EHASLPHISFYLMVKRRISAEECTFRSS....
A0A4P9VNA6_9GAMM/8-198 ...mlccalgslastcfsynnsyn-------------------------QHNYS.P.SATLILQNTTLNNQVKYINFSSIT....EEK....LDYKNFK-..-IIENDILENNTIYWIDFTQSISQNGEHLNHEKVKKLFGIVYQEDMLLISSYKGKLLYTPFNSANSTLFSQLTnQLLNNSHSSRK.RVARDVTTNTSKEStvsdDKKAPPNVSFYINVFRPITDEECTFKRS....
A0A1C3J2L0_9VIBR/7-185 ..................igilvt--------SVLISRSVLASDTLQEGINIPV.G.ESIHIMSDMVDNSDLVYINAKYWL....ESG....IYSNGI--..ENAIDLIVNNGYRYLVDFSEIEGNKEKIKAKHVFRKVFGISLESDYIAITEHNHNVMFTEIKDRYDTN----I.PILS--KPAPK.RQKRSTSNTPAVH-....--SPVPSISRYYNATKQITDSECD----itwn
A0A2T3N0F1_9GAMM/1-182 ....................mirk-----TNLITLAMMGLMATTTWAAGIDEPA.G.SAINMLSSLQDVSSVNYINAEYLL....DND....VMPLSLT-..-EIKTQVLNEDKRYFIDFSNIATEVDKNTAKSKLRHSMGIGLTGDMIIISAYKGELMFSQLDGEDDPN----I.TLLEGEPKRAS.RNKRSTTQLSNPD-....--NSIPNVAFYLHANRRISDRECNL---twn.
A0A0N0DJB1_PHOLD/2-194 ........................LIGRRCFTVIMAMFCSLFISISSANDDLPQ.G.LAVQILSQLQNSEQVNYVNAENWLi..dKNQ....NANKNVASslTQIKTKVLKYNKPTLVDFSSVTGESQKVKAKELFRKQIGISFPDDLLIITKHKGELMFSPIRGDDDPS----I.ALLESNSNKVNdIDLSDKIGESLSNY....EHDFFPHLSFYLRVNRNITPEECTFKRS....
D0YYQ7_PHODD/4-185 .................rklysci----------LLGLSSLSASAIADVDNYST.GaDVISILSSVQNPDRIVYVNMK---....--Q....EEISTY--..NRILEDIIYNDKQYIFDLS-FDNNEEKEKLQKKFKDLMGVKFDSNFIVVTGYKNQLMYTPIADANDRMVSVLD.HEARSNDISKY.PMALALRSGNATSD....QSISLPHVSFYLNVNKEITDQECTFRNS....
HLYA_VIBCH/3-187 ......................kl---NRCAIAIFTILSAISSPTLLANINEPS.G.EAADIISQVADSHAIKYYNAADWQ....AED....NALPSLA-..-ELRDLVINQQKRVLVDFSQISDAEGQAEMQAQFRKAYGVGFANQFIVITEHKGELLFTPFDQAEEVD----P.QLLEAPRTARL.LARSGFASPAPANS....ETNTLPHVAFYISVNRAISDEECTFNNS....
#=GR HLYA_VIBCH/3-187 SS ......................XX---XXXXXXXXXXXXXXXXXXXXXXXXXXX.X.XXXXXXXXXXXXXXEEEEEGGGGG....XXX....XXXXXHH-..-HHHHHHTTSXXEEEEEXTTXXSHHHHHHHHHHHHHHHSXBXXSSEEEEEEETTEEEEEEESSXXXXX----X.XXXXXXXXXXX.XXXXXXXXXXXXXX....XTTSS-EEEEEEEEEEE--TTTTEEES-....
D0Z5B0_PHODD/4-185 .................rklysci----------LLGLSSLSASAIAEVDNYSTpA.DVVSILSSVKNPDRIVYINMKQ--....---....EE--LSTY..DSILEDIINNDKQYIFDLSFDSD-EEKANIQKKFKDLMGVKFDSNFIVVTGYKNQLMYTPISDTNDRMISILD.HEAKSDDISKF.PRALALSSGKVASD....QSISLPHVSFYLNVNKEITDQECTFRNS....
E3BMX3_9VIBR/30-194 ..........lavfhhfpvfahpm----------------------------QS.D.TALLIMQSVYSPSNINYINLNEVS....D-D....ALEKSLP-..-AVNDNVINENKKYLLDFSQLEDNDKIERYQKQIQSRIGMSIVTPFLAITNYQGSMLFTPISDSLDPQIQRLN.EDN--SRPSSS.RKRRSVQKISP---....-----PKLSFYVSLNKQFSESDCLFPR-v...
HLY1_AERHH/9-196 ........................FITQAPTLSLLA-LALLAGSVQAEDIGERT.D.QGTAMLASLQSEQGLIYLNADVWL....KRQ....GATPLMTR..DQLRERVLARGERLFIDFSAVTDQSERQQTRKAMEQLAGISFDADWVLVSGYKGELLFTPLGGVDDPAFYQVM.ERVESLEGQGK.RHKRSLTQPPAAE-....--AGLPHVAFYLNVNRKISDAECTFPRS....
A0A0N0V990_PHOLD/4-186 tlpimilalnsvsvsvsvsamipi----------------------EQQIGYQS.P.LAIEGMQKISDLSNIVYININDIH....ND-....YISQEYDF..SKIENNVMNNNKKYFLDFSDFESNDAKEKAFDIISNHFGVSFSSNAVLITKEKGKLAFSLINSSDSPF-FESL.NDIQSDDD---.-DLYGYTGN-----....DKAILPIKTFLIRTSKKITYEDCAFPR-y...
A0A0M9F8E7_PHOLD/3-194 ...............vngkycfym----------LSIAFVFYSTLVKAEGDEPQ.G.LAINILSQLKNSEQVNYVNAENWLi..dKNQnvnkNVTSSLT-..-QIKTKVLKYNNPTLVDFSHITDESQKVKAKELFRKQIGISFPDDLLIITKHKGELMFSPIVGDEDPSITLLE.FNINNVNDIDL.TERIGEA---LSKD....EHKSLPHLSFYLKINRIITPQECTFRSS....
A0A178K7H8_9GAMM/7-195 faltplaailfscsvqasqyheae----------------------AFSMYEPV.G.DAVNIVSRINDPEGLRYINAKYWL....NDN....DDL-SLGF..DRVDQIVKDEGGRYLIDFTEIFDYSDKIKAKKLFSRIFGISFDADYVAITKYKESLLFTELTGSGDQN-VTIL.NRTYEPMALAL.MSDDPYQPLVPK--....-QIPVPNVAFYVNASRQISDQDCKI---ewn.
A0A0Q2MKS2_VIBFU/1-163 .......................m-----------------------ADIHDPV.G.EAVSILSQVSDSSQINYFNAQYWQ....GND....SDMPTLA-..-QLRQFVVQEKQRILMDFSQIENNEERAVMQALFRQQYGMSFASRFILVTEHKGELLFTPFDVADDVN----P.ALLEAPAAKRV.RRSLSDTQRVSGG-....EANTLPHVAFYINVNRAISDEECTFDNS....
#=GC SS_cons ......................XX---XXXXXXXXXXXXXXXXXXXXXXXXXXX.X.XXXXXXXXXXXXXXEEEEEGGGGG....XXX....XXXXXHH-..-HHHHHHTTSXXEEEEEXTTXXSHHHHHHHHHHHHHHHSXBXXSSEEEEEEETTEEEEEEESSXXXXX----X.XXXXXXXXXXX.XXXXXXXXXXXXXX....XTTSS-EEEEEEEEEEE--TTTTEEES-....
#=GC seq_cons ....................h.hh..........hh.hs.h..sh.ttshspPs.G.pAlsILSplpsssplsYINAp.Wh....ppp....st..ols....pIcspVlpps++YllDFSplpspscKtcs+chF+cthGlSFsucallITpaKGcLhFTPlssssDss....h.phlcsscspph.ppppuhsp.sssp.....ppsslPHVoFYlsVNRpIoDpECTFppS....
//
