GenomeNet

Database: Pfam
Entry: Herpes_US12
LinkDB: Herpes_US12
Original site: Herpes_US12 
#=GF ID   Herpes_US12
#=GF AC   PF05363.13
#=GF DE   Herpesvirus US12 family
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF SE   Pfam-B_62991 (release 7.8)
#=GF GA   21.00 21.00;
#=GF TC   21.40 21.20;
#=GF NC   20.50 20.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   10521276
#=GF RT   Structure of the active domain of the herpes simplex virus
#=GF RT   protein ICP in water/sodium dodecyl sulfate solution determined
#=GF RT   by nuclear magnetic resonance spectroscopy. 
#=GF RA   Pfander R, Neumann L, Zweckstetter M, Seger C, Holak TA, Tampe
#=GF RA   R; 
#=GF RL   Biochemistry 1999;38:13692-13698.
#=GF DR   INTERPRO; IPR008026;
#=GF DR   SCOP; 1qlo; fa;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   US12 a key factor in the evasion of cellular immune response
#=GF CC   against HSV-infected cells. Specific inhibition of the
#=GF CC   transporter associated with antigen processing (TAP) by US12
#=GF CC   prevents peptide transport into the endoplasmic reticulum and
#=GF CC   subsequent loading of major histocompatibility complex (MHC)
#=GF CC   class I molecules [1]. US12 is comprised of three helices and is
#=GF CC   associated with cellular membranes [1].
#=GF SQ   4
#=GS A0A1G7FIS8_9PROT/79-141  AC A0A1G7FIS8.1
#=GS ICP47_HHV11/1-82         AC P03170.2
#=GS ICP47_HHV11/1-82         DR PDB; 1QLO A; 1-34;
#=GS D3YPN1_HHV1/1-82         AC D3YPN1.1
#=GS ICP47_HHV2H/1-86         AC P14345.2
A0A1G7FIS8_9PROT/79-141             lldl-----------------------------LRRQREAREAAREATEDPGEPILSlPPWLVPDVRA-----------------------elraivqelsryararqpgfavla
ICP47_HHV11/1-82                    ....MSWALEMADTFLDTMRVGPRTYADVRDEINKRGREDREAARTAVHDPERPLLR.SPGLLPEIAP----NASLGVAHRRTGGTVTDSP........................
#=GR ICP47_HHV11/1-82         SS    ....-TTSHHHHHHHHHT-SSS---HHHHHHHHHHT--XXXXXXXXXXXXXXXXXXX.XXXXXXXXXX----XXXXXXXXXXXXXXXXXXX........................
D3YPN1_HHV1/1-82                    ....MSWALEMADTFLDNMRVGPRTYADVRDEINKRGREDREAARTAVHDPERPLLR.SPGLLPEIAP----NASLGVAHRRTGGTVTDSP........................
ICP47_HHV2H/1-86                    ....MSWALKTTDMFLDSSRCTHRTYGDVCAEIHKREREDREAARTAVTDPELPLLC.PPDVRSDPASRNPTQQTRGCARSNERQDRVLAP........................
#=GC SS_cons                        ....-TTSHHHHHHHHHT-SSS---HHHHHHHHHHT--XXXXXXXXXXXXXXXXXXX.XXXXXXXXXX----XXXXXXXXXXXXXXXXXXX........................
#=GC seq_cons                       ....MSWALchsDhFLDs.Rss.RTYuDVpsEIpKRtREDREAARTAVcDPEcPLLp.sPsLlP-lAs....ptohGsA+pppttshs.uP........................
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