GenomeNet

Database: Pfam
Entry: HpuA
LinkDB: HpuA
Original site: HpuA 
#=GF ID   HpuA
#=GF AC   PF16960.5
#=GF DE   Haemoglobin-haptoglobin utilisation, porphyrin transporter
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF SE   HMMER:P96948-TCDB
#=GF GA   29.70 29.70;
#=GF TC   29.80 30.90;
#=GF NC   27.00 25.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 45638612 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   9157245
#=GF RT   Molecular characterization of hpuAB, the
#=GF RT   haemoglobin-haptoglobin-utilization operon of Neisseria
#=GF RT   meningitidis.
#=GF RA   Lewis LA, Gray E, Wang YP, Roe BA, Dyer DW;
#=GF RL   Mol Microbiol. 1997;23:737-749.
#=GF DR   INTERPRO; IPR031586;
#=GF DR   TC; 1.B.14;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   HpuA is a family of Neisseria spp proteins from the hpuAB
#=GF CC   operon, which are putative porphyrin transporters.
#=GF SQ   15
#=GS D3A0G7_NEIMU/31-331      AC D3A0G7.1
#=GS D7N494_9NEIS/136-245     AC D7N494.1
#=GS F0EX68_9NEIS/28-338      AC F0EX68.1
#=GS F0EX68_9NEIS/28-338      DR PDB; 5EC6 A; 15-320;
#=GS F0EX68_9NEIS/28-338      DR PDB; 5EE4 B; 15-320;
#=GS F0EX68_9NEIS/28-338      DR PDB; 5EE4 A; 15-320;
#=GS D2ZXZ1_NEIMU/113-246     AC D2ZXZ1.1
#=GS G4CJC2_9NEIS/33-335      AC G4CJC2.1
#=GS A0A1X3CU30_9NEIS/35-343  AC A0A1X3CU30.1
#=GS G2DNB9_9NEIS/48-337      AC G2DNB9.1
#=GS A0A2H9X2T2_9NEIS/35-341  AC A0A2H9X2T2.1
#=GS A0A1X3CHH0_9NEIS/39-338  AC A0A1X3CHH0.1
#=GS F5S5I1_9NEIS/28-342      AC F5S5I1.1
#=GS C0DRU0_EIKCO/35-324      AC C0DRU0.1
#=GS A0A0H4IWK3_NEIG1/35-330  AC A0A0H4IWK3.1
#=GS A0A0H4IWK3_NEIG1/35-330  DR PDB; 5EE2 A; 194-341;
#=GS A0A286E8H0_9NEIS/19-316  AC A0A286E8H0.1
#=GS E5UIT9_NEIMU/13-146      AC E5UIT9.1
#=GS A0A0H4IWK3_NEIG1/1-49    AC A0A0H4IWK3.1
D3A0G7_NEIMU/31-331                 ..........................................VAIPTAQPI-..-ANVKLSDESNAIKTINTLSG---....KGGSLHEAE.L..EVKT..SWG...-SYT.DKQYIYQTPSGNYYNISSYSDPII-PSYSSPSY.ALRTRHEGQPLSEGGKLFVCCSNSGQFSYAPATKHDH....LKFGAWISSDGTADLFVGGKPVGSAKP...SWSTPSDSTv.aKGKTTYEVWAVRVRNGNIV...TSTYD....PGK.S-SGSSEKNTPKL.S.LLTANFNTNKLGGTILGNA.DYGPDVVMKDVGING..VDFSGTAESDGK.NGKVEGKFFGQ.....FNG..gY....-K.....T.....E...VSIGGKVTFDADKSLDTVFGGVENLSDRN.-T.TDTSLTPVS-q...............
D7N494_9NEIS/136-245                ...........................ratsmpvsgvanyav----------..------------------------....---------.-..----..---...----.---------------------------------.-------------------------------------....---------------------------...---------...-------------------...-----....--K.G-INNYTGNNPLV.G.TLRADFGQKVLAGSMRNNA.M-QMDIHSR-IKPSS..ASFEGYARANGH.YGKTEGHFFGH.....NAS...A....--.....-.....-...--LAGVAKFKTNRNLDTAFGGVK------.--.----------r...............
F0EX68_9NEIS/28-338                 ............pltaapipvlravdttspnivadtstdreq----------..-------------------RTFAT....QGGSVKPFT.I..TKPSpyIPG...LMLT.NQEILYQAPDGKYYDFGTYNTLIM-PSSSTSAR.VLPNSHPMQPLDSGGKMIACCTNQTS-TGMNALRLKS....MQFGAWMSPSKTVSLFAGGTPAPTDTL...QGVDTAGRP...TGKATYEVIGLRVKNDRAV...TSSYE....TRY.S--PYNTGQVVTG.S.FLTVNFNTGKLGGTIVGNS.EFGDSIEMRDVNVNG..NQFSGTASSGGH.TGQVSGGLFAK.....EER..fY....SGtlehpS.....G...GEIGGTVNFGSNSPLNASFGGTRREYNAA.DTsTDTS------hlv.............
#=GR F0EX68_9NEIS/28-338      SS    ............XXXXX----B--B-TTSTTEEE---GGG------------..-------------------EEEET....TS-EEEEEE.E..EEE-SSSTT...-EEE.EEEEEEE-TTS-EE---STTB-------SSS-E.E--SEEE-EEBTTS-EEEES--SSTT--S-GGG--SS....EEEEEEE-TTS-EEEEEEE-B--GGGS...TTHHHHSS-...-SEEEEEEEEEEEESSEEE...E---E....E--.---------EEB-.E.EEEEETTTTEEEEEE--BT.TTBS-EEEEEEEEET..TEEEEEEEETTE.EEEEEEEEE--.....-EE..-T....TS-EEE-S.....-...-EEEEEEESSTT-TT-EEEEEEEEEEETT.----S-----------.............
D2ZXZ1_NEIMU/113-246                ...yygewvgkeyakgtnrgvfysgdkratsmpvsgvanyav----------..------------------------....---------.-..----..---...----.---------------------------------.-------------------------------------....---------------------------...---------...-------------------...-----....--K.G-INNYTGNNPMA.G.TLRADFGQRVLAGSMRNNA.V-NMDVHAR-IKPSS..ASFEGYARANGH.FGKTEGHFFGH.....NAS...A....--.....-.....-...--LAGVAKFKTDRNLDTAYGGVK------.--.----------r...............
G4CJC2_9NEIS/33-335                 .........................................a-TMPTVSPLN..VSDVQPLQGSYTGHNFNAAQPVSShsnpAVGTLKAVS.L..PKEV..LLN..vYNDR.KNVFIYETADGKQYALLGTGNPFVPTAATSVS-.VAPPRVKMSETAAGDKFIVCCDQFYNSRFIPARVGDHddggVRYGVWISASGRVDMFYGGTPAVPAQM...LGASGNGGV..pRGKATYEVAAFRVRDGQAV...MSTHD....V--.-------ANTANR.S.LLTVNFNSRKMGGTILGNA.EFGDNIVFGDVSVDG..ASFSGSVTSAGV.SGQVEGSFYGR.....NH-...-....-T.....T.....G...SYIGGRAVFNGRNDLDSVFGGSI------.--.----------rrqgqasyvgddvnhl
A0A1X3CU30_9NEIS/35-343             ........................................ve--RPTLQPFDagAANVKKHADTDNYFTVSTNGG-AV....EKYTVTTKE.K..SSWS..DSY...YDVN.KDVTVYKTPDGKYYQFGNFNTPIV-PDYSSPSK.QFLTSHEMQATEDGGKIFACCD-SYHTDRPAIDMRGT....MYYGAWISPKGEASLFAGGSLADAAYM...QGGSEAKGA...KGKATYDVWGIRVKDGKVV...SSSYT....PKN.P---HNADAPTVI.S.QLTVNFNTGKLGGEIIGNK.DFGSSVIMKDVNVNG..NKFSGTATSGEA.TGQVEGAFFGA.....HRK..sY....YSg..giS.....EyggKSIGGTVKFDGNKALDTAFGGTRTAIDTE.-T.KSTDLTPL--k...............
G2DNB9_9NEIS/48-337                 ................................kseisfeagv----------..-----LHADDSKLVTLHTLDD--P....KQAKLRKLD.I..HHHG..NFG...-PRV.DDAFVYQTPDGKLFRFGTYNTPIL-QDGFSPSY.TLKNSHEGQATENGGRLFACCS--FQWRQASATRLDN....VGYGAWIDPNGKVDLFVGGVPADVAKM...QGAWNNEGK..pKGTAIYEVWGVREKGGKFV...TSSYTgfstPTD.G---KYPRGKPEA.S.YILVNFNTNKLGGTILGNQ.DYGPDVVMGNVDIVG..NSFSGSAKSGGV.NGNVEGKFFSS.....D--...-....--.....-.....G...KEIGGKVVFDQSRSLDTVFGGMRDKYNPS.--.-D--------esldlpti........
A0A2H9X2T2_9NEIS/35-341             ............................vempvlksldtksd----------..--KVKAHKDDAEFETIAT------....NGGSVHKYN.VteKVKS..SWSdsyYDKT.DEVVVYTTADGKSYQFNQFNTAMR-PDYSSPSK.TYPTKQVMQPTEDGGKIFACCTNSRVDQPATYVKSSY....--FGAWMDKNGVVSLFSGGILAEQEYM...QGGVKAGGV...KGKATYDVIGYRVKNGEIV...SSSYT....PKD.P---YVQDSKEQV.S.RLTVNFNTGKLGGTIIGNS.DFGDSVTFDNVNVEG..NKFHGTAKSGGV.SGKVNGAFYGK.....VYKg.yY....GD.....AireyaG...KEIGGTVNFG-NKNLDTVFGGSRTQVDTT.--.TD--------skdlnpvv........
A0A1X3CHH0_9NEIS/39-338             ........................vpvptlsalnpqdpnvig----------..------PTPNLEIETFNANSE--T....SGKVVSWQI.K..EKNI..FGE...-LVA.RDKFAYQTPDGKVYVFNTYTNPILPDS-FHPDK.NLRTKHDMQATDDGGKLFACC-ENGQRQYTGTT-GNA....VRYGAWIDKNGKADLFVGGILADATKM...QGATEENKFs.pTGKATYEVWALRVKNGGVV...SSSYR....PNT.F-----PNKDGVQ.S.LLTVNFNTGKLGGTIVGNS.DFGADIRFDDVSVQG..NRFSGSASSGGV.AGKVEGAFYGR.....-GG...Y....RT.....P.....H..gDQIGGKVVFDKDRNLNSVFGGATSNSMRN.-P.NDTSRD----lnpi............
F5S5I1_9NEIS/28-342                 ................svpeiivpqivaraldktsasvqakp----------..--------------DANVATFSSN....SDSKIEQYT.I.sEPSI..IPG...VLRV.EDELVYTLASGKSYRFDKFNTLVL-TSQSTPGIrKLPNVQAMTPTDDGGRIIACCDSSVSGMLFSDLK--A....SRFGIWMSPTGQAEVFSGGKLAVAADL...QGSNVNGQP...KGKATYQVVALRSKGNHAV...TSTFE....STY.TS--SSYATAVNV.S.RLTVNFNTNKLGGTIIGNQ.DFGAPVEMKDVTLNG..SKFSGTAESAGK.IGRVEGGLFGEawrspYSGn.fY....YNg...aG.....G...KEIGGVITFPADKSLNTAFGGVRSNYDDK.-T.DSQDLTP---vnn.............
C0DRU0_EIKCO/35-324                 .....ltpadsskilgpastgetpttfqtgngqlryvswyve----------..------------------------....---------.-..----..YWG...TPSS.ENKFIYQAPNGKSYAFDGFTNPPRFSSRFTPDK.NQPTKMEPQTSSDGNKLLVCCENGDAN--FPAGYLQS....LRYGAWIGADGQTDLFAGGILANTADM...QKRNGATAP...TGKATYEVWAFRVKGGSVV...ASSYN....TDT.N------PAKRVN.S.LLTVNFNTGKVGGTIKGNA.DFGADIDFNDVTVNG..NTFSGTASSGGV.SGQVNGGFYGK.....SGW...Y....DP.....A.....G...TEIGGKVTFNGNRSLDSVFGGSATDTRRDpDT.TATDLTPV--np..............
A0A0H4IWK3_NEIG1/35-330             ............................sdapsrsrrsldaa----------..--------------------PQNT....SGISIRQRE.V..EKD-..YFG...YKSK.ETSFIFKTPGGAQYALSSYADPIT-VSYSSPDF.KIPDRHAGQRLADGSRIFICCSDSGATSYAEITKQDY....MKFGAWIGPNGEIDLFAGGFPVGKTPPpafSYGSSTPETalsKGKITYQVWGIRVRNGQFV...TSSYT....PPKsGSYYGTLANTPVL.S.FITANFNSNTLAGKILGNS.DYGPDVDIQNATITG..PTFSGDATSGGK.SGKLEGKFFGK.....FAS...T....RS.....S.....E...VSIGGKITFDGDRSLDTVFGGVSYEKKLD.DT.-SQDTNHLT-k...............
#=GR A0A0H4IWK3_NEIG1/35-330  SS    ............................XXXXXXXXXXXXXX----------..--------------------XXXX....XXXXXXXXX.X..XXX-..XXX...XXXX.XXXXXXXXXXXXXXXXXXXXXXXX-XXXXXXXX.XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX....XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--SSEEEEEEEEEEEETTEEE...E----....-----------------.E.EEEEETTTTEEEEEE--BT.TTBS-EEEEEEEEET..TEEEEEEEETTE.EEEEEEEEE--.....---...-....--.....-.....-...-EEEEEEE-TT-GGG-EEEEEEEEEEETT.--.----------X...............
A0A286E8H0_9NEIS/19-316             ...........................acsgssieepkvfvs----------..---------------LNTAQAVSE....SQVQTQDSSrA..TVST..HGG...EVLSaGSLMVYKTPDGKYYPLGE-SNTLIRPVYSSPDK.TFGTKQYMQNTDNGGKLFACCTGAGVDVPAAHVKSSY....--YGAWLAKDGTSSLFSGGVLADPAHM...Q-GGANNPN...KGKASYDVLAVRVKNGELV...NSSYT....PKN.A---NHADAPTVI.S.RLTVNFNTGKLGGTILGNR.DFGNDIVMKDVSVNG..NTFQGSAVSGSA.TGAVEGAFYGA.....QSTwsqYtaqdRH.....S.....G...NEIGGIVKFGN-ANLDAAFGGSRTALDTT.-T.TSTDLNPLS-n...............
E5UIT9_NEIMU/13-146                 .................................vrlsvqkvr----------..------------------------....---------.-..----..---...----.---------------------------------.-------------------------------------....---------------------------...---------...---ITPPSTAARVEPTNLPttgTATYT....V-K.GINQYHAQNSTVLnG.TLTADFSSNKLSGSLK-NS.--GLTIAINNAAIKTaeASFSGNATANGT.AGATHGHFFGN.....QGA...V....--.....-.....-...--IAGVAEFGRNHAYNTAFGGTK------.--.----------tgk.............
A0A0H4IWK3_NEIG1/1-49               .........................................m-SIPTATPLP..AGEVTLSSDNGNIENINTAGAGSA....SDA------.-..----..---...----.---------------------------------.-------------------------------------....---------------------------...---------...-------------------...-----....---.-------------.-.-------------------.---------------..------------.-----------.....---...-....--.....-.....-...-----------------------------.--.----------psrsrrsldaap....
#=GC SS_cons                        .....................B..B.TTSTTEEEXXXGGGXX----------..-------------------EEEET....TSXEEEEEE.E..EEE-SSSTT...XEEE.EEEEEEEXTTSXEEXXXSTTBXXX-XXXSSSXE.EXXSEEEXEEBTTSXEEEESXXSSTTXXSXGGGXXSS....EEEEEEEXTTSXEEEEEEEXBXXGGGSXXXTTHHHHSSXX--SSEEEEEEEEEEEETTEEE...E---E....E------------EEB-.E.EEEEETTTTEEEEEE--BT.TTBS-EEEEEEEEET..TEEEEEEEETTE.EEEEEEEEE--.....-EE...T....TS.EEE.S.....-...-EEEEEEESTTTGCC-EEEEEEEEEEETT.--.-S--------X...............
#=GC seq_cons                       .................................hp.ss.hss...........................hts.t........pthplp..p.h..p.......s......s.cp.hlYpsssGK.Ythspassshh.ss..oPsh.th.spp.hQshpsGu+lhsCCsttht...hshhh.p.......aGAWhs.sGpssLFsGGh.Asss.h...phustssts...pGKATY-VhuhRV+sGphV...oSoYs....stp.s......sssssh.S.hLTVNFNTsKLGGTIlGNu.DaGsslthcsVslsG..ssFSGoApSuGt.sGpVEGtFFGc.....pst...h.....t.....s.....t...tpIGGplsFsss+sLDTsFGGs+pt.p.p.....s........p...............
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