GenomeNet

Database: Pfam
Entry: KptA_kDCL
LinkDB: KptA_kDCL
Original site: KptA_kDCL 
#=GF ID   KptA_kDCL
#=GF AC   PF18176.3
#=GF DE   KptA in kinetoplastid DICER domain
#=GF AU   Iyer LM;0000-0002-4844-2022
#=GF AU   Aravind L;0000-0003-0771-253X
#=GF AU   Burroughs AM;0000-0002-2229-8771
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   Laks
#=GF GA   68.70 68.70;
#=GF TC   77.50 76.60;
#=GF NC   59.90 58.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   27536007
#=GF RT   RNA damage in biological conflicts and the diversity of
#=GF RT   responding RNA repair systems.
#=GF RA   Burroughs AM, Aravind L;
#=GF RL   Nucleic Acids Res. 2016;44:8525-8555.
#=GF DR   INTERPRO; IPR040715;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   KptA ADP-ribosyltransferase domain observed in kinetoplastid
#=GF CC   DICER-like (DCL) enzymes. Appears to have lost most residues
#=GF CC   required for catalyzing phospho-transfer to NAD; however,
#=GF CC   several positively-charged residues implicated in RNA end
#=GF CC   recognition remain well-conserved [1].
#=GF SQ   6
#=GS A4HE49_LEIBR/304-500      AC A4HE49.2
#=GS A0A0N0DYH2_9TRYP/410-610  AC A0A0N0DYH2.1
#=GS A4HCQ0_LEIBR/424-620      AC A4HCQ0.1
#=GS Q57XV6_TRYB2/279-431      AC Q57XV6.1
#=GS F9WIL2_TRYCI/282-434      AC F9WIL2.1
#=GS Q57XF2_TRYB2/357-507      AC Q57XF2.1
A4HE49_LEIBR/304-500                 ..PVTHLRAAWGH..KDADVAAAVIQEHIPVLLnslvhlSEVDIGDSRAVPqptdchkdpardkctsgpsyssWLEYVADVKViRKEAAGASGRVYPQYR..PMQVLIPEPVVDALcaplqlvrLQYNTSTATALTELIQRTRAHNTMLRGADGTVGSSSASGLAKVTFAELLa..lLQPP.......................................SgfCVAVFLAAMTGHA---ARLAFLPV....
A0A0N0DYH2_9TRYP/410-610             ..GQRCARSVYGHalLNPPLYRHIICQPDCLL-......RPNDELAIASLP......................LYGWVALSAK.PQKSLDEHMSILRLFDniAFCVVMPAEAIGAF........RDYDE--TTPQTKKYDEKL-RKKVVYFAEVYLRALARDGEATVLDMDGSd.ltLSSPsvtsrmssavsslnsrttlpplppasaaatpstaptapgS..TTEVYSSFLGEASSKTQRWYVFPQ....
A4HCQ0_LEIBR/424-620                 ..GQRCARSLYAHeiRSPLLYRQIICQRERLV-......QPDDATAVSNLP......................LFGWVALPQH.PSKVLGVHPSLFPLFDniPFFVAMPAEAIGMF........RDYEE--RTPKAKKYDEKL-RKPHLWFAEVYLRAIARDGQVMTGEADGG....PASSplsssvmgtrstslssiis.atswaveegshdcdtaqsaT..CTEVYTRVGGTSNPATQRWYVFPQ....
Q57XV6_TRYB2/279-431                 ..CSVSVRAAWAH..KDSSLASKVVSDHPKMAL......EKALEIFSPCRE......................IYDFVESVER.WEVAAKLHGREIPTFR..PFLMLAVGDSIRA-........RIPKDPVRRAAALLASKVTTKSAFLSVSRSFLGLHLQRPVCVVHSNIFE....----.......................................-..GGAMHLRQTAGHGQPPRGVLLLH-l...
F9WIL2_TRYCI/282-434                 ky---SVRAAWAH..KDFFMAQAVLSSHPMMTL......KEAIDKFGRGKR......................LYDFVESLDR.WKAELTKGGRSVPVFR..PFLLLAVGDVIES-........RITGDCTQQAATLLSNKVVSGSAFLPIHEHFLNMHEECRVHVVHSHFVNgvgaV--Pfeaa...............................pggeS..CGVVFL------------------lpvs
Q57XF2_TRYB2/357-507                 ..GLQCARALYGHegRNLLM-KSVFDSFSTIR-......------DPGGRP......................STGWMRIDGKrMKLVSKDKGYSLHDSI..PHVTIHSTESLHAF........QWYRL--KKPLEEQYDEILSSRKPLYFAEFRLHDALNDDRMLVRELKGIg..aVPPQ.......................................W..--VVFTEHNRDDD-HQRSTLVIPE....
#=GC seq_cons                        ..s.pssRAsauH..+ss.lhppVlsp+splh.......p.s.thsssuhP......................lasaVt.sp+.hctshst+Gp.lPhFc..PFhllhsu-uIcAh........R.Yc-..ppstschhschls+pshLhhAEsaLpsttpcshshVpptcsts..hl.ss.......................................o..sssVahphhssps...pphhlhP.....
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