GenomeNet

Database: Pfam
Entry: LPD22
LinkDB: LPD22
Original site: LPD22 
#=GF ID   LPD22
#=GF AC   PF18834.1
#=GF DE   Large polyvalent protein associated domain 22
#=GF AU   Mistry J;0000-0003-2479-5322
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF AU   Iyer LM;0000-0002-4844-2022
#=GF AU   Aravind L;0000-0003-0771-253X
#=GF AU   Burroughs AM;0000-0002-2229-8771
#=GF SE   Iyer LM
#=GF GA   27.00 27.00;
#=GF TC   29.10 47.40;
#=GF NC   26.70 24.70;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 45638612 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   28559295
#=GF RT   Polyvalent Proteins, a Pervasive Theme in the Intergenomic
#=GF RT   Biological Conflicts of Bacteriophages and Conjugative Elements.
#=GF RA   Iyer LM, Burroughs AM, Anand S, de Souza RF, Aravind L;
#=GF RL   J Bacteriol. 2017; [Epub ahead of print]
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This is a predicted enzymatic alpha-helical domain with highly
#=GF CC   conserved aspartate residues [1]. The domain is found in
#=GF CC   polyvalent proteins of phage and prophage genes and is often the
#=GF CC   immediate neighbour of a lysozyme gene [1].
#=GF SQ   44
#=GS H8FP78_PHAMO/35-132      AC H8FP78.1
#=GS A0A1Y4GNW3_9BACT/40-145  AC A0A1Y4GNW3.1
#=GS A0A0U1KXI5_9FIRM/19-119  AC A0A0U1KXI5.1
#=GS A0A1B7XA28_9DELT/57-156  AC A0A1B7XA28.1
#=GS A0A1L3ZVI6_9SPHN/18-117  AC A0A1L3ZVI6.1
#=GS A0A1G3JM00_9SPHN/14-110  AC A0A1G3JM00.1
#=GS A0A1G8AP24_9RHOO/26-123  AC A0A1G8AP24.1
#=GS A0A246SLH7_9RHIZ/63-166  AC A0A246SLH7.1
#=GS A0A023CFG6_9PSED/34-132  AC A0A023CFG6.1
#=GS A0A1H4HT81_9BURK/50-148  AC A0A1H4HT81.1
#=GS A0A0Q4JIQ9_9SPHN/25-122  AC A0A0Q4JIQ9.1
#=GS G9ZG80_9GAMM/3-96        AC G9ZG80.1
#=GS A0A073ITB4_9BACT/38-142  AC A0A073ITB4.1
#=GS B6WT73_9DELT/18-111      AC B6WT73.1
#=GS A0A1B7XAY0_9DELT/33-132  AC A0A1B7XAY0.1
#=GS T0H2D0_9SPHN/34-130      AC T0H2D0.1
#=GS A0A0A0EVV4_9GAMM/20-116  AC A0A0A0EVV4.1
#=GS K7ZRM7_9CAUD/18-115      AC K7ZRM7.1
#=GS A0A1F4GVL6_9BURK/44-141  AC A0A1F4GVL6.1
#=GS A0A0B2JY12_9FIRM/71-184  AC A0A0B2JY12.1
#=GS N6X718_9ALTE/42-139      AC N6X718.1
#=GS Q6LJT0_PHOPR/42-141      AC Q6LJT0.1
#=GS A0A196MP94_9SPHN/33-129  AC A0A196MP94.1
#=GS Q775D4_BPBPP/40-139      AC Q775D4.1
#=GS V7FHU5_9RHIZ/19-123      AC V7FHU5.1
#=GS R9B6Z4_9GAMM/9-114       AC R9B6Z4.1
#=GS J8VW42_9SPHN/39-136      AC J8VW42.1
#=GS F7T9E5_9BURK/28-126      AC F7T9E5.1
#=GS A0A1B7X8P5_9DELT/31-130  AC A0A1B7X8P5.1
#=GS A0A2D8J5E9_9ALTE/22-119  AC A0A2D8J5E9.1
#=GS A0A1C9VHP3_9BURK/35-132  AC A0A1C9VHP3.1
#=GS C1D7V1_LARHH/17-116      AC C1D7V1.1
#=GS A0A0R3Q2Z1_9BILA/1-93    AC A0A0R3Q2Z1.1
#=GS A0A0M4CXX7_SPHS1/38-136  AC A0A0M4CXX7.1
#=GS K4NZ44_9CAUD/42-139      AC K4NZ44.1
#=GS A0A2A5YNE9_9SPHN/33-129  AC A0A2A5YNE9.1
#=GS R5E2S4_9BURK/63-161      AC R5E2S4.1
#=GS A0A243PEU0_9SPHN/28-124  AC A0A243PEU0.1
#=GS A0A106BIY4_THIDE/34-130  AC A0A106BIY4.1
#=GS A0A1L8P9Y3_9RHIZ/16-120  AC A0A1L8P9Y3.1
#=GS A0A0A1F935_9BURK/59-157  AC A0A0A1F935.1
#=GS A0A1N6KP96_9BURK/42-140  AC A0A1N6KP96.1
#=GS A0A238YRR4_9PROT/41-138  AC A0A238YRR4.1
#=GS A0A0B8ZJZ7_9SPHN/48-146  AC A0A0B8ZJZ7.1
H8FP78_PHAMO/35-132                 ...arlgsn------LIAAADTNP....DAHAKAMEIGRQIG.......APADAIAAN.L............GEGERMA........KLQKMREAL..GSAPKLAE.FLtSDPDMAKLSSD..DFSALTRLEGSMTAAA------sfgrg.
A0A1Y4GNW3_9BACT/40-145             .....dele----RSYERYVTENP....DEAAARAWNAERVG.......VPLWVQERS.Dky........anEA----KkrlallekGTPDWKKLA..DASPVTAS.FM.TGDGVMASAHD..DVQGLADIEDVTHSLSYL----rlny..
A0A0U1KXI5_9FIRM/19-119             ......npl---GQVMQVAKNLPQ....DQAAKILKYSLASG.......DAPILVANN.L............HAYETDI.......vDQIDWDNVL..QQSPKTYE.FL.NNPLHMAAVRDqqNVATLSNLENSWLSWHDLKEG-g.....
A0A1B7XA28_9DELT/57-156             .........RSAAPMLEYAVTRNP....DTVADAQKIAKRTG.......MDADFVEQN.Y............DQLSAQD........RAERQQRLM..ETMDAGGTmYFmRDPVNAGMAHD..DLENLIRIEQESNPFRALGK--ta....
A0A1L3ZVI6_9SPHN/18-117             ........q-DARAASMAVVGINP....DSDADLQRKAQSLG.......IPIESARRD.P............QGFEQRVr......eTNTDWDEMA..RTRPITTR.LM.GSASKAAIAQD..DVANMAELERKFGSIRAQRQ--pe....
A0A1G3JM00_9SPHN/14-110             .........RDAQTAFQI-KVAKP....DETARANAIAKERG.......VPAAIVQSD.L............PNFEAQQ........RATRANEVM..RQNPAIGR.WS.AKPGNTAIAAD..DYDNLGLFGKAFYGLKLTG---rni...
A0A1G8AP24_9RHOO/26-123             kalreqyra----------TSITP....DDAAKVIDISARTG.......IPKPVVVRN.Q............SEAAKLA........AEPDWDGLQ..VTAPVTVR.ELaANTKLFDLAHD..DTDNLSELERTMNRRSEG----qigg..
A0A246SLH7_9RHIZ/63-166             ........a-AAADIILRSSDEDP....DQVASDLRIAEDYAgatgrpaPPLELVKQH.R............ESFRQAT........QEARNAEIL..STSPILAA.LL.RRPGNAALASD..DVEALGYFERVSKVTVT-----qvpl..
A0A023CFG6_9PSED/34-132             .......np---RTALSYVADTNP....DEQASIQRLAELTG.......VAPDMVVRN.R............KQVERQAk......lASVDYDALI..ERAPATNQ.FL.TDPDNASVAHD..DIDGLSNVEGAFDNFVKE----sgqq..
A0A1H4HT81_9BURK/50-148             ........q-TAQSNIALAVGANP....DYEAEMQRLAQQTG.......TPVDSVKAF.P............DVVKQKAt......vNSIDFQNLA..KQFPTTAA.FY.QSQNNAKIAHD..DVGGLQSVEQATTNLGPA----snv...
A0A0Q4JIQ9_9SPHN/25-122             ......rrd---AAISRRIQDANA....EQAARVSQLARELD.......YPETLVSAD.L............PAFEARA........KSYRAQGVI..AQYPAIGA.WS.AKGSNADIAAD..DYDKLGLFGKAFYGLKNVG---gtl...
G9ZG80_9GAMM/3-96                   .....dnir----LTLDQAFGENP....DQYARDREIGRGLG.......MPPRLLNDSdR............SIY----........RAIQSDTAL..QDLPVTRR.FY.GNYDNAVLAQD..DSENLGKIEHRLR-LR------qvrewg
A0A073ITB4_9BACT/38-142             ...kleevy------TKY-AAEDP....EAHARRVWTAEAVG.......VPQWIQERD.Em.........yaKEAERRLal...ltkGMPDWRGLS..EKYPLTAR.FF.EDEDVMASAND..DVEALAAKEGEARRAGAVAKA-l.....
B6WT73_9DELT/18-111                 .....raal-----EVADADGVTA....QRVASARATALQLG.......LPDSVVEAD.L............QYAQREA........QARRIE---..QNSPFALW.AA.RSKERAALARD..DTDGLAGVFSTAKAFGEIRQ--ye....
A0A1B7XAY0_9DELT/33-132             .........RSAAPMLEYAVTRNP....DTVADAQKIAKRTG.......MDADFVEQN.Y............DQLSAQD........RAERQQRLM..ETMDAGGTmYFmRDPVNAGMAHD..DLENLIRIEQESNPFRALGK--ta....
T0H2D0_9SPHN/34-130                 .....rdde----LAYRI-KVARP....DEEARARALAEPRG.......LAPSAVASN.L............PAFEAEA........RAAKAKNVM..SQYPAIGR.WS.AKPGNAAIAAD..DYDNLSLFGKAFYGLKNFGK--tl....
A0A0A0EVV4_9GAMM/20-116             ......era--REAAI-TSPAIAP....DDMAKAQRLGAAHG.......IGPQAVADD.L............KHYDELD........QVDRMERFA..TSTPGASR.WL.-TPERAALVRD..DVDTLERLGRALPSKGATMRA-t.....
K7ZRM7_9CAUD/18-115                 ....arara----AGI-TAPQVEP....DAMGRAMRLADQRG.......LPPGVVADN.L............PEYDQQQ........QLDALGDAA..SASPALAR.WL.GDPNHTALSKD..DTGVLAGLGRQFNSGL------lsaket
A0A1F4GVL6_9BURK/44-141             ......trl---TSTLDMALPRNP....DKAAEAKGLAERFR.......MDIDTAAAK.Q............DELARIA........RQQDITRMV..ADSPVLAR.QL.SDLNFAELAHD..NVENMGAIERTIRGLGPAAM--sg....
A0A0B2JY12_9FIRM/71-184             ........v-SALYASNIIQNTDT....EKAARLEEATNILG.......IKDDYAKRN.ViqsgmankqimdAAFQAAKsk....anSPEDWDAFV..EDNPATAK.YL.TDQKNMAVSLD..DINPLAGLENTITSIKDHLEL-s.....
N6X718_9ALTE/42-139                 ......vla----RSVNQAVTEQP....DDLAYIRRLSEDTG.......LSPYIVREN.R............DDIERRV........KQREMGAQI..EGFSQPGKeWL.SRPDNLGVAQD..DLPALRALDDAIANRDWYAQD-s.....
Q6LJT0_PHOPR/42-141                 .......fq--LSTSMKYGREADP....ERAGRVFRQQLKTG.......LPSELIERN.L............DDIEKQS........AEKDFDPVAfrNKSPLLSG.WL.QKPENAKVSHD..DLENLSTMEWLFRAPVEAYQD-g.....
A0A196MP94_9SPHN/33-129             ........r-DEEMAFRI-KVAKP....DEAARAGAIAKARG.......LPAAVVESN.L............PAFEMEA........RAARAKAAA..QDYPAIGR.WS.AKGNNAAVAAD..DYDNLSLLGKAFYGLKNVGKT-v.....
Q775D4_BPBPP/40-139                 ........q-AARAGFVLASDTDP....DAYAEAQRVARRAN.......LPIETVLNQ.P............KEAKRQDt......iGAIDFDTLG..KTSPATAA.LL.ADVEKAKIAHD..NVDNMTGIESVLSSLGTAVK--yl....
V7FHU5_9RHIZ/19-123                 ........v-GAAQVVLGSVNEKP....DEIAGDLNLANEFGkatgnpvPPLPMVREY.R............NVFQQKI........EEQKNKTIL..SSKPRLTE.WL.RSPDNAALARD..DLQNLSWFEGFGRGVTNTLS--rs....
R9B6Z4_9GAMM/9-114                  .......lt--IGQLLELNQGKNPtqiaDTEARARKAAKSLG.......LDYSKITQT.P............EEIASVAde....vnTQKRINDVV..ASDPVLGK.YA.LDPNQAAISLD..DFGGLKRVSDSVLLLKPSIT--ep....
J8VW42_9SPHN/39-136                 ...rdaqir------DGLLSAPAP....DAVARTERLARDTG.......SSVADVQGN.E............DTAERGL........QVRKMVDLA..GRDPAVGR.WAaNNPRSAAMAQD..DYENLSLLGQAWDWVKKV----pga...
F7T9E5_9BURK/28-126                 .......at---RVSVAAALGSNP....DLEAELRQVASRTG.......IPIDSVRRH.P............EEVKREAa......lTSFDFERLA..RDYPSTAA.YL.AGVENARIAHD..DVDNMGVIEKGIRGLSNLGS--aa....
A0A1B7X8P5_9DELT/31-130             .........RSAAPMLEYAVTRNP....DTVADAQKIAKRTG.......MDADFVEQN.Y............DQLSAQD........RAERQQRLM..ETMDAGGTmYFmRDPVNAGMAHD..DLENLIRIEQESNPFRALGK--ta....
A0A2D8J5E9_9ALTE/22-119             ......lgl----KAYSLTETDEP....DRAARDLKLAQENG.......VPRVSVSTD.R............DRYETLS........EWNRVNLET..QDAPMTRA.WLrGSRDNYAIARD..EVKDISMLEKLMSTGSSVMYW-g.....
A0A1C9VHP3_9BURK/35-132             ......rav---RGSLTATAQTTP....ERAAQLNYLAQVSG.......MPRAVVETD.E............GSAKAVA........QLREIWDAS..ADSPVLRA.KL.ANPQFTELAKD..DVGVLSQIERGVQATTRYI---mga...
C1D7V1_LARHH/17-116                 ......dql---AGSLRDALQVNP....DDYAKTVRLAKAAG.......VEVEAVPLY.A............DVAQEAQy......lEGIGFRSLW..KDSPKTAE.FL.SDARNARLAHD..DVANLSVLEKLARSAGAGLT--aa....
A0A0R3Q2Z1_9BILA/1-93               ......msv---------GLGANP....DMEAELRKVARRTG.......VPVDTARAY.P............EELKRQAa......mGQMDFDSLA..QQFPRTAG.FL.SGTENAKVAHD..DVENMGLIETMINSFQR-----gipa..
A0A0M4CXX7_SPHS1/38-136             .........RDRQTRLDLLLSASP....DTVGRATTIAKEIG.......VPPMHVEDR.L............AEAEKGR........HVRRFMSVA..ERYPAIGK.WAvTQPRGAAAASD..DWDSLSLLGKTWRSTREVAT--gi....
K4NZ44_9CAUD/42-139                 ......qdf---VHSMETVSNISP....DAYAKATAVSRYSG.......VPAKVLHDN.A............DRMNQLL........RGNQYAGIY..TNYRKTAN.AL.RDGNLAAVSQD..DLDQLVRIEGAASDTRFNQQ--st....
A0A2A5YNE9_9SPHN/33-129             ........r-DEEMAFRI-KVAKP....DEAARAGAIAKARG.......LPAAVVESN.L............PAFEMEA........RAARAKAAA..QDYPAIGR.WA.ASQSNVAVAAD..DFDGLLKIAKALDPVDWARS--gs....
R5E2S4_9BURK/63-161                 .........RDAYSASQFVLGKDP....GRTAEVLDISRQLG.......ISPTEVDSD.F............EGSKYRL........EKLRTANTL..KQSPGLSD.YItNNPDKAPVLKN..DLKPLTKTDILLNELAEKMA--ar....
A0A243PEU0_9SPHN/28-124             ........a-AARRSIIMHNAASP....DAAARANVLSRENG.......LPPTIVEQH.L............PAFEIAR........RSERANALM..AKHPAIGR.WS.SDPRNIAAAAD..DYDNLGKLGAAFASR-------iardkr
A0A106BIY4_THIDE/34-130             ....avrag------ATLALDSNP....DEIARQKRIAQSLG.......VPLAAVEAD.P............EFATREQ........RVRSIEQAT..ANSPALRQ.KF.SDADFAKLAAD..NVDNLSGIEQLLRSAKRGFT--ag....
A0A1L8P9Y3_9RHIZ/16-120             ........v-GAASVVLGSLEEKP....DQVAGDLNLANDFGkvtgnpaPPLPMVKEY.R............NVFQQKI........EEQKNKTIL..SKAPVLTE.WL.RNPENAAVARD..DLEGLSWWETTFKAGGNAMSR-g.....
A0A0A1F935_9BURK/59-157             ........q-QAQAVAVTNSTASS....DTAARAAKIAPQVN.......APQAAIETD.L............PRYEAQA........KAQDNAAVM..AQSPQMAK.WAvANPDAARVAQD..DLGKMSTMETLLGAASDSG---anf...
A0A1N6KP96_9BURK/42-140             ........q-AAQGVAVANSEQSA....DAAGRAAGIAKQIG.......APQAAVETD.L............PRYEAQA........KAQNNAQIL..SQSPRLAD.WVaNNPDSARVAQD..DFDGMSQLEGLTSAQSAQA---lta...
A0A238YRR4_9PROT/41-138             .....qrtg----LVLDVVSGINP....DNAAKAKKLSQTFG.......LAPESVEKD.L............PEFERRA........RIRENQAIL..AASPILAR.QI.SDPEFAKLAQD..DTANLSGIETLLRSFKRGLT--sg....
A0A0B8ZJZ7_9SPHN/48-146             ..rgrmlga-------TLRASPAP....DQAAQANRIARARG.......LPAAVVDPK.L............QVLQIAD........QATNFLNMT..RLFPHIGS.WAeANPRDAAAAAD..DTKALGMLGHAFSERDLS----rgys..
#=GC seq_cons                       ........h.....shphshstsP....DpsAcspclAcphG.......lPsshVcps.h............sthcpps........pspchpslh..pstPshup.ah.sssssAulApD..Dl-sLutlEpshpuhpthh...s.....
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