#=GF ID   L_biotic_typeA
#=GF AC   PF04604.19
#=GF DE   Type-A lantibiotic
#=GF AU   Waterfield DI;0000-0003-2885-5126
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF SE   Pfam-B_4608 (release 7.5)
#=GF GA   21.70 21.70;
#=GF TC   21.70 21.90;
#=GF NC   21.60 21.50;
#=GF BM   hmmbuild  HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -E 1000 -Z 81514348 HMM pfamseq
#=GF TP   Family
#=GF CL   CL0400
#=GF RN   [1]
#=GF RM   7601145
#=GF RT   Biosynthesis and biological activities of lantibiotics with
#=GF RT   unique post-translational modifications. 
#=GF RA   Sahl HG, Jack RW, Bierbaum G; 
#=GF RL   Eur J Biochem 1995;230:827-853.
#=GF DR   INTERPRO; IPR007682;
#=GF DR   TC; 1.C.21;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   Lantibiotics are antibiotic peptides distinguished by the
#=GF CC   presence of the rare thioether amino acids lanthionine and/or
#=GF CC   methyl-lanthionine. They are produced by Gram-positive bacteria
#=GF CC   as gene-encoded precursor peptides and undergo
#=GF CC   post-translational modification to generate the mature peptide.
#=GF CC   Based on their structural and functional features lantibiotics
#=GF CC   are currently divided into two major groups: the flexible
#=GF CC   amphiphilic type-A and the rather rigid and globular type-B.
#=GF CC   Type-A lantibiotics act primarily by pore formation in the
#=GF CC   bacterial membrane by a mechanism involving the interaction with
#=GF CC   specific docking molecules such as the membrane precursor lipid
#=GF CC   II [1].
#=GF SQ   27
#=GS A0A1E5LFE1_9BACI/1-48   AC A0A1E5LFE1.1
#=GS A0A1E3L342_9BACL/1-45   AC A0A1E3L342.1
#=GS A0A421BHK0_9LACT/1-54   AC A0A421BHK0.1
#=GS A0A0X3V1S6_9ACTN/1-36   AC A0A0X3V1S6.1
#=GS A0A291KJB5_BROTH/1-45   AC A0A291KJB5.1
#=GS A0A940IMU8_9BACI/1-48   AC A0A940IMU8.1
#=GS A0A1G6ADN6_9STRE/1-51   AC A0A1G6ADN6.1
#=GS E8K2N8_9STRE/1-38       AC E8K2N8.1
#=GS A0A1R1SE91_9ACTN/1-30   AC A0A1R1SE91.1
#=GS A0A7X6N1S4_9STRE/1-57   AC A0A7X6N1S4.1
#=GS A0A3S8RWB3_9BACL/1-57   AC A0A3S8RWB3.1
#=GS A0A940P6S3_9ENTE/1-48   AC A0A940P6S3.1
#=GS A0A6I6RZM6_9ACTN/1-36   AC A0A6I6RZM6.1
#=GS Q99Y19_STRP1/4-51       AC Q99Y19.1
#=GS A0A3S4Y533_9ACTN/1-51   AC A0A3S4Y533.1
#=GS A0A4R1QWX5_9FIRM/1-47   AC A0A4R1QWX5.1
#=GS A0A926NFB0_9BACI/1-43   AC A0A926NFB0.1
#=GS A0A3E2N8H5_9CLOT/1-47   AC A0A3E2N8H5.1
#=GS A0A4P6YU33_9LACO/1-52   AC A0A4P6YU33.1
#=GS A0A2N8PJ54_STRNR/1-38   AC A0A2N8PJ54.1
#=GS A0A265QAL3_9FIRM/1-50   AC A0A265QAL3.1
#=GS A0A421BDH3_9LACT/1-56   AC A0A421BDH3.1
#=GS F9ECH4_9ACTO/2-44       AC F9ECH4.1
#=GS B2JB92_NOSP7/7-57       AC B2JB92.1
#=GS A0A2M9M9X7_9ACTN/1-38   AC A0A2M9M9X7.1
#=GS A0A7D4BIL7_9BACL/23-67  AC A0A7D4BIL7.1
#=GS A0A1H3PL14_9PSEU/1-33   AC A0A1H3PL14.1
A0A1E5LFE1_9BACI/1-48              ........................MENL--......KFNAVIEDVTDQELDLATGAga.kpGDGWISTITDDCPN.---..-SIIVCC.....
A0A1E3L342_9BACL/1-45              .................mkelfvd------......--LSAVEDITEAELQAAVAP.....GDGWITTLTDDCPN.---..-SIIVCC.....
A0A421BHK0_9LACT/1-54              ........................MKDTNIi...diEATNTLQELSLDELDTIIGA....gKEGVVPTISHDCHM.NSW..QFIFTCC.....
A0A0X3V1S6_9ACTN/1-36              ......................mn------......NAQVQTQEISDADLDNVSGG....lVGGVLNTVTT----.---..-------tad..
A0A291KJB5_BROTH/1-45              .......................m------......KNLNLLEEVTEEELDTILGA.....GNGAIRTISHECHM.NTW..QFLFTCC.....
A0A940IMU8_9BACI/1-48              .................meeikle------......---MVVDSLSDEELAEIAGGa..rpGPGWIKTVTLDCPA.ATF..WC-----cg...
A0A1G6ADN6_9STRE/1-51              ........................MMNAT-......ENQIFVETVSDQELEMLIGG....aDRGWIKTLTKDCPNvISS..ICAGTII.....
E8K2N8_9STRE/1-38                  .......................m-VKQQMnl.veiEAMNSLQELTLEELDNVLGA.....GGGVIQ--------.---..-------i....
A0A1R1SE91_9ACTN/1-30              ...................mnnap------......--KVATQEISDAELDNVAGG.....VGHVV---------.---..-------gd...
A0A7X6N1S4_9STRE/1-57              ........................MKNTNIi...diEATNALQELSFEELDTIIGAkk.kgNDGAIPTISHDCHM.NSW..QFIFTCC.....
A0A3S8RWB3_9BACL/1-57              ........................MNNLNV......NAMAAIEDISDEELMVITGAaavaaSGGVICTISHECHY.NSVspAAWATCC.....
A0A940P6S3_9ENTE/1-48              ........................MEE-M-......KHMNLLEEVTEEELDAILGA.....GNGVIKTISHECHM.NSW..QWIFTCC.....
A0A6I6RZM6_9ACTN/1-36              ......................mn------......NAQVQTQEISDADLDNVSGG....lVGGVLSTVTT----.---..-------ttd..
Q99Y19_STRP1/4-51                  ........................MKNSKD......ILTNAIEEVSEKELMEVAGGk...kGSGWFATITDDCPN.---..-SVFVCC.....
A0A3S4Y533_9ACTN/1-51              ........................MQNKYD.....dQTLDNLAELSDTEIEELLGA.....GWGSIFSFTHECNT.NTM..TQLFTCC.....
A0A4R1QWX5_9FIRM/1-47              ........................MRN---......DILNLTNPMEEKELEQILGG.....GNGVIKTISHECAM.NTW..QFLFTCC.....
A0A926NFB0_9BACI/1-43              ......................me------......ELKNVVEVLSDEELQEAAGA....aGCGWRCTITDDCPN.---..-SIFVCC.....
A0A3E2N8H5_9CLOT/1-47              ........................MRN---......DILELTNPMEEKELEQILGG.....GDGVIKTISHECAM.NTW..QFIFTCC.....
A0A4P6YU33_9LACO/1-52              ........................MKMN-E......VALTALDEVSELELNDILGAk..gkGSGVIKTLTHECKM.NTY..QAILTCC.....
A0A2N8PJ54_STRNR/1-38              ......................mn------......NAQVQTQEISDADLDNVSGG....lVGGVLSTVTT----.---..-------tvgsi
A0A265QAL3_9FIRM/1-50              ...................meder-----Ld...yfNMNEVIDEISNEELEMATGA....gEGEWYRTITKKCPS.---..-SLFTCC.....
A0A421BDH3_9LACT/1-56              ........................MKQKNKqsdaeiKAVDALQEVSLEELDKIIGA.....GNGVVYTLTHECNL.ATW..TKKLKCC.....
F9ECH4_9ACTO/2-44                  .....................tad------......----ILVEMTDAELDATLGA.....GNGVFHTISHECYY.NSW..AFIFTCC.....
B2JB92_NOSP7/7-57                  nqnpkqasdyieinedgelvvkdp------......KLAESLQELTPEELEQIAGG.....DNGN----------.---..-------cnc..
A0A2M9M9X7_9ACTN/1-38              ......................mn------......NAQVQTQEISDADLDNVSGG....lVGGVLSTVTT----.---..-------tvdsv
A0A7D4BIL7_9BACL/23-67             ................npagdvym------......-------ELEEAELDQVVGG....tEAQAFATIGAKCTV.ETC..SAVIWC-.....
A0A1H3PL14_9PSEU/1-33              ...................mseqe-----Ik....nEAAETPEEVTIEELDQLAGG.....GGE-----------.---..-------ti...
#=GC seq_cons                      ....................................phhshlpElo-pEL-plhGu.....ssGslpTloc-C..........hhhCh.....
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