#=GF ID   L_biotic_typeA
#=GF AC   PF04604.16
#=GF DE   Type-A lantibiotic
#=GF AU   Waterfield DI;0000-0003-2885-5126
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF SE   Pfam-B_4608 (release 7.5)
#=GF GA   21.70 21.70;
#=GF TC   21.70 21.80;
#=GF NC   21.60 21.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF CL   CL0400
#=GF RN   [1]
#=GF RM   7601145
#=GF RT   Biosynthesis and biological activities of lantibiotics with
#=GF RT   unique post-translational modifications. 
#=GF RA   Sahl HG, Jack RW, Bierbaum G; 
#=GF RL   Eur J Biochem 1995;230:827-853.
#=GF DR   INTERPRO; IPR007682;
#=GF DR   TC; 1.C.21;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   Lantibiotics are antibiotic peptides distinguished by the
#=GF CC   presence of the rare thioether amino acids lanthionine and/or
#=GF CC   methyl-lanthionine. They are produced by Gram-positive bacteria
#=GF CC   as gene-encoded precursor peptides and undergo
#=GF CC   post-translational modification to generate the mature peptide.
#=GF CC   Based on their structural and functional features lantibiotics
#=GF CC   are currently divided into two major groups: the flexible
#=GF CC   amphiphilic type-A and the rather rigid and globular type-B.
#=GF CC   Type-A lantibiotics act primarily by pore formation in the
#=GF CC   bacterial membrane by a mechanism involving the interaction with
#=GF CC   specific docking molecules such as the membrane precursor lipid
#=GF CC   II [1].
#=GF SQ   21
#=GS Q99Y19_STRP1/4-51       AC Q99Y19.1
#=GS A0A1E5LFE1_9BACI/1-48   AC A0A1E5LFE1.1
#=GS A0A0X3V1S6_9ACTN/1-36   AC A0A0X3V1S6.1
#=GS A0A3S4Y533_9ACTN/1-51   AC A0A3S4Y533.1
#=GS I6XQR7_PSEPQ/1-51       AC I6XQR7.1
#=GS B2JB93_NOSP7/20-61      AC B2JB93.1
#=GS A0A059W2A7_STRA9/1-37   AC A0A059W2A7.1
#=GS A0A1H3PL14_9PSEU/1-33   AC A0A1H3PL14.1
#=GS A0A421BDH3_9LACT/1-56   AC A0A421BDH3.1
#=GS A0A1E3L342_9BACL/1-45   AC A0A1E3L342.1
#=GS A0A421BHK0_9LACT/1-54   AC A0A421BHK0.1
#=GS A0A3E2N8H5_9CLOT/1-47   AC A0A3E2N8H5.1
#=GS A0A265QAL3_9FIRM/1-50   AC A0A265QAL3.1
#=GS A0A4R1QWX5_9FIRM/1-47   AC A0A4R1QWX5.1
#=GS A0A7D4BIL7_9BACL/23-67  AC A0A7D4BIL7.1
#=GS A0A291KJB5_BROTH/1-45   AC A0A291KJB5.1
#=GS A0A4P6YU33_9LACO/1-52   AC A0A4P6YU33.1
#=GS A0A3S8RWB3_9BACL/1-57   AC A0A3S8RWB3.1
#=GS A0A1G6ADN6_9STRE/1-51   AC A0A1G6ADN6.1
#=GS F9ECH4_9ACTO/2-44       AC F9ECH4.1
#=GS B2JB92_NOSP7/6-58       AC B2JB92.1
Q99Y19_STRP1/4-51                  .........................MKNSKD......ILTNAIEEVSEKELMEVAGGK...kGSGWFATITDDCPN.---..-SVFVCC..........
A0A1E5LFE1_9BACI/1-48              .........................MENL--......KFNAVIEDVTDQELDLATGAGa.kpGDGWISTITDDCPN.---..-SIIVCC..........
A0A0X3V1S6_9ACTN/1-36              ........................m-----N......NAQVQTQEISDADLDNVSGGL....VGGVLNTVTT----.---..-------tad.......
A0A3S4Y533_9ACTN/1-51              .........................MQNKYD.....dQTLDNLAELSDTEIEELLGA-....GWGSIFSFTHECNT.NTM..TQLFTCC..........
I6XQR7_PSEPQ/1-51                  .......................mq--SNYD.....dQILDNLAELSDTEIEELLGA-....GWGSIFSFTHECNT.NTM..TQLFTCC..........
B2JB93_NOSP7/20-61                 ..............nengelvvtdp------......KLAESLQELSTEELEQIAGGV....--------------.---..-------lptngtctnn
A0A059W2A7_STRA9/1-37              ........................m-----N......NAQVQTQEISDADLDNVSGGL....VGGVVNTVTT----.---..-------tvgs......
A0A1H3PL14_9PSEU/1-33              ....................mseqe-----Ik....nEAAETPEEVTIEELDQLAGG-....GGE-----------.---..-------ti........
A0A421BDH3_9LACT/1-56              .........................MKQKNKqsdaeiKAVDALQEVSLEELDKIIGA-....GNGVVYTLTHECNL.ATW..TKKLKCC..........
A0A1E3L342_9BACL/1-45              ..................mkelfvd------......--LSAVEDITEAELQAAVAP-....GDGWITTLTDDCPN.---..-SIIVCC..........
A0A421BHK0_9LACT/1-54              .........................MKDTNIi...diEATNTLQELSLDELDTIIGAG....KEGVVPTISHDCHM.NSW..QFIFTCC..........
A0A3E2N8H5_9CLOT/1-47              ........................m-RN---......DILELTNPMEEKELEQILGG-....GDGVIKTISHECAM.NTW..QFIFTCC..........
A0A265QAL3_9FIRM/1-50              ....................meder-----Ld...yfNMNEVIDEISNEELEMATGAG....EGEWYRTITKKCPS.---..-SLFTCC..........
A0A4R1QWX5_9FIRM/1-47              ........................m-RN---......DILNLTNPMEEKELEQILGG-....GNGVIKTISHECAM.NTW..QFLFTCC..........
A0A7D4BIL7_9BACL/23-67             .................npagdvym------......-------ELEEAELDQVVGGT....EAQAFATIGAKCTV.ETC..SAVIWC-..........
A0A291KJB5_BROTH/1-45              ........................m------......KNLNLLEEVTEEELDTILGA-....GNGAIRTISHECHM.NTW..QFLFTCC..........
A0A4P6YU33_9LACO/1-52              .........................MKMN-E......VALTALDEVSELELNDILGAKg..kGSGVIKTLTHECKM.NTY..QAILTCC..........
A0A3S8RWB3_9BACL/1-57              .........................MNNLNV......NAMAAIEDISDEELMVITGAAavaaSGGVICTISHECHY.NSVspAAWATCC..........
A0A1G6ADN6_9STRE/1-51              .........................MMNAT-......ENQIFVETVSDQELEMLIGGA....DRGWIKTLTKDCPNvISS..ICAGTII..........
F9ECH4_9ACTO/2-44                  ......................tad------......----ILVEMTDAELDATLGA-....GNGVFHTISHECYY.NSW..AFIFTCC..........
B2JB92_NOSP7/6-58                  enqnpkqasdyieinedgelvvkdp------......KLAESLQELTPEELEQIAGG-....DNG-----------.---..-------ncncn.....
#=GC seq_cons                      .....................................phhsslpElo-pEL-plhGu.....usGsltTloc-C..........lhsCC..........
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