#=GF ID MCR_D
#=GF AC PF02505.17
#=GF DE Methyl-coenzyme M reductase operon protein D
#=GF AU Mian N;0000-0003-4284-4749
#=GF AU Bateman A;0000-0002-6982-4660
#=GF SE Pfam-B_2115 (release 5.4)
#=GF GA 25.00 25.00;
#=GF TC 25.50 30.40;
#=GF NC 24.40 23.40;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 8863453
#=GF RT Phylogeny of Methanopyrus kandleri based on methyl coenzyme M
#=GF RT reductase operons.
#=GF RA Nolling J, Elfner A, Palmer JR, Steigerwald VJ, Pihl TD, Lake
#=GF RA JA, Reeve JN;
#=GF RL Int J Syst Bacteriol 1996;46:1170-1173.
#=GF RN [2]
#=GF RM 3170483
#=GF RT Structure and comparative analysis of the genes encoding
#=GF RT component C of methyl coenzyme M reductase in the extremely
#=GF RT thermophilic archaebacterium Methanothermus fervidus.
#=GF RA Weil CF, Cram DS, Sherf BA, Reeve JN;
#=GF RL J Bacteriol 1988;170:4718-4726.
#=GF DR INTERPRO; IPR003901;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC Methyl coenzyme M reductase (MCR) catalyses the final step in
#=GF CC methanogenesis. MCR is composed of three subunits, alpha
#=GF CC (Pfam:PF02249), beta (Pfam:PF02241) and gamma (Pfam:PF02240)
#=GF CC [1]. Genes encoding the beta (mcrB) and gamma (mcrG) subunits
#=GF CC are separated by two open reading frames coding for two proteins
#=GF CC C and D [2]. The function of proteins C and D (this family) is
#=GF CC unknown.
#=GF SQ 83
#=GS Q2FSN3_METHJ/8-150 AC Q2FSN3.1
#=GS A0A062V0J7_9EURY/13-163 AC A0A062V0J7.1
#=GS A0A0A7LAM9_9ARCH/16-140 AC A0A0A7LAM9.1
#=GS A0A0X3BPL7_9EURY/8-150 AC A0A0X3BPL7.1
#=GS D7E8Y0_METEZ/14-155 AC D7E8Y0.1
#=GS A0A498GYM4_9EURY/8-150 AC A0A498GYM4.1
#=GS A0A1D2WA08_9EURY/2-137 AC A0A1D2WA08.1
#=GS A0A1F2P9G5_9EURY/48-128 AC A0A1F2P9G5.1
#=GS MCRW_METTH/9-157 AC Q50485.2
#=GS F4BXY3_METSG/11-152 AC F4BXY3.1
#=GS A0A0X3BM21_9EURY/8-149 AC A0A0X3BM21.1
#=GS R9TBQ1_METII/13-137 AC R9TBQ1.1
#=GS A0A0Q4B337_9ARCH/4-130 AC A0A0Q4B337.1
#=GS E3GZ54_METFV/2-135 AC E3GZ54.1
#=GS E1RDX7_METP4/10-152 AC E1RDX7.1
#=GS U6EEL5_9EURY/8-156 AC U6EEL5.1
#=GS A0A1D3L4R9_9EURY/2-136 AC A0A1D3L4R9.1
#=GS A0A1D2WB23_9EURY/2-137 AC A0A1D2WB23.1
#=GS MCRW_METFV/11-160 AC Q49172.1
#=GS A0A0W7TIG7_9ARCH/1-122 AC A0A0W7TIG7.1
#=GS R9SP78_9EURY/2-142 AC R9SP78.1
#=GS A0A166A6P3_9EURY/2-139 AC A0A166A6P3.1
#=GS A0A6B9T9X5_9ARCH/18-143 AC A0A6B9T9X5.1
#=GS A0A1V6N4G6_9EURY/2-139 AC A0A1V6N4G6.1
#=GS D5EAD9_METMS/13-154 AC D5EAD9.1
#=GS Q8THG8_METAC/13-154 AC Q8THG8.1
#=GS D3E053_METRM/2-141 AC D3E053.1
#=GS A6UWG9_META3/3-148 AC A6UWG9.1
#=GS A0A484F515_9EURY/20-161 AC A0A484F515.1
#=GS F0T8R0_METLA/2-136 AC F0T8R0.1
#=GS F6BBJ0_METIK/10-159 AC F6BBJ0.1
#=GS W9DQG9_METTI/12-153 AC W9DQG9.1
#=GS A0A1Y3GAR2_9EURY/4-138 AC A0A1Y3GAR2.1
#=GS Q0W342_METAR/13-153 AC Q0W342.1
#=GS L0HF34_METFS/10-152 AC L0HF34.1
#=GS Q2NI01_METST/20-168 AC Q2NI01.1
#=GS G7WN22_METH6/11-153 AC G7WN22.1
#=GS M9SHS0_METAX/15-140 AC M9SHS0.2
#=GS A0A062V6Q2_9EURY/13-163 AC A0A062V6Q2.1
#=GS A0A1F2P4Q0_9EURY/50-129 AC A0A1F2P4Q0.1
#=GS A0A328S3N1_9EURY/15-163 AC A0A328S3N1.1
#=GS A0A2V2MWE9_9EURY/8-150 AC A0A2V2MWE9.1
#=GS L0KYV7_METHD/13-154 AC L0KYV7.1
#=GS A0A328PI59_9EURY/2-137 AC A0A328PI59.1
#=GS F0TCV3_METLA/8-156 AC F0TCV3.1
#=GS Q12TF5_METBU/13-154 AC Q12TF5.1
#=GS A0A1D2W9X6_9EURY/8-156 AC A0A1D2W9X6.1
#=GS A0A166F276_9EURY/2-139 AC A0A166F276.1
#=GS F6BE94_METIK/3-148 AC F6BE94.1
#=GS A0A1F2P4Q0_9EURY/14-52 AC A0A1F2P4Q0.1
#=GS D1YW09_METPS/17-157 AC D1YW09.1
#=GS A0A2Z4L887_9EURY/15-163 AC A0A2Z4L887.1
#=GS I7J9I9_METBM/8-150 AC I7J9I9.1
#=GS I7KD24_METBM/51-192 AC I7KD24.1
#=GS A0A483CYB8_9EURY/8-149 AC A0A483CYB8.1
#=GS A0A110A3F8_9ARCH/15-140 AC A0A110A3F8.1
#=GS A0A2U1S6W9_9EURY/2-141 AC A0A2U1S6W9.1
#=GS A0A1Q6DVN8_9EURY/3-126 AC A0A1Q6DVN8.1
#=GS B8GE90_METPE/8-149 AC B8GE90.1
#=GS D1YVW3_METPS/13-152 AC D1YVW3.1
#=GS MCRD_METJA/5-153 AC Q58253.1
#=GS F1SVE8_METKA/13-163 AC F1SVE8.1
#=GS MCRW_METJA/16-162 AC Q57582.1
#=GS A0A4E0PYS3_9EURY/12-153 AC A0A4E0PYS3.1
#=GS A0B6N8_METTP/14-155 AC A0B6N8.1
#=GS F7XL11_METZD/12-153 AC F7XL11.1
#=GS A0A0Q4B5G7_9ARCH/13-139 AC A0A0Q4B5G7.1
#=GS Q0W5P0_METAR/19-159 AC Q0W5P0.1
#=GS A0A2V3JKK1_9EURY/11-154 AC A0A2V3JKK1.1
#=GS Q6LWZ8_METMP/3-148 AC Q6LWZ8.1
#=GS MCRD_METTH/2-135 AC O27235.1
#=GS Q8PXH5_METMA/13-154 AC Q8PXH5.1
#=GS D7DUH2_METV3/3-148 AC D7DUH2.1
#=GS A0A483CQJ0_9EURY/8-149 AC A0A483CQJ0.1
#=GS A0A366M859_9EURY/2-139 AC A0A366M859.1
#=GS L0HJW7_METFS/8-149 AC L0HJW7.1
#=GS A0A328S7V5_9EURY/9-157 AC A0A328S7V5.1
#=GS A7I5U2_METB6/8-150 AC A7I5U2.1
#=GS A0A166CF39_9EURY/2-139 AC A0A166CF39.1
#=GS U6EC36_9EURY/2-136 AC U6EC36.1
#=GS M4YM91_THEXX/1-123 AC M4YM91.1
#=GS H1YXI2_9EURY/10-149 AC H1YXI2.1
#=GS A2STS2_METLZ/8-150 AC A2STS2.1
Q2FSN3_METHJ/8-150 ....QCRIVTERLLKPETVEKILNKLAV.I.PGIRRIVINGPSIPQKVPYGPARGLDNPHSGKATIRVGVTDVDLRVQVGTFLLELE......TRDIVSQVEEACKEVFT..nFSYSVKEGK..FMRSTPTQVDYAKYGPN.........ANEIMLGLVDPKNKT---gpt............
A0A062V0J7_9EURY/13-163 ....QIRVFPKRLLQPETAEKLLNEIDQ.T.KGVIRMLLNGKNLPRKVTCGPGTGADVNHPDRMIINVGGCAFELHIIVGEVIVEVE......NESAMEDVKKACERALP...FPFEFKRGH..FIKRRPTLTDYGKYGFRsktderinlEDERILGLIDPHAKAE--tn.............
A0A0A7LAM9_9ARCH/16-140 ....EVEVFSNVLLSHGTTEKVLNALDP.I.KHIRQINMTGESLPKNLNSGPAKGLPNDHSERKVIKVGGRDVELRFLVGAFYIELDveneamLDEAVKKIKAACDATLP...RGFSLTVGR..YSKYRKTLRDY------.........------------------r..............
A0A0X3BPL7_9EURY/8-150 ....QVRIVSARFLRPDTVEQLLNRLVQ.V.GGIRRMSINGPSLPATVPYGPARGKPNPHPDRKAIRVGNQDVQLQVQVGTIILELE......DESYIPAIEEAVDEVFAekdFSCTVQQGR..YMKTRPSMSDYARYGPD.........ADREILGIVDPRRK----dg.............
D7E8Y0_METEZ/14-155 ....QIELFPTRLLKPETTQNLLEELSE.V.DGIIRAFIHGPRLPLTVPSGPATGQDVEHPHRKVIQIGDTAIELSISVGRIRLEIT......DEDVEEEIETIAEKVLP...CKYELREGY..FIPKESTVTDYAKRGPN.........ADPKRRGLSDPKASEES-q..............
A0A498GYM4_9EURY/8-150 ....QCRIVSARFLKPDTAERLLNRIVE.V.GGIRRMSINGPSIPATVPYGPARGKPNPHPDRKAIHVGDQEIQLRVQVGTIVLELE......DESIIPAMKEACDEIFAdlgFSYTFQQGR..FMKTQPSLSDYVKYGPD.........AEDQILGLVDPKRK----dg.............
A0A1D2WA08_9EURY/2-137 ....DIEIFPHRYLSADTTENLLKDLDE.I.GGVKRMVLQGQRLP------PAE---SGHPDRRIITLKGQEIDLQVKTGRILIEIE......AEPVIDELRDVCENHLP...FGFNIHVGT..YIRRQKTVTDKLKYGEKl......geIPDELIGLTDQNAQLSE-r..............
A0A1F2P9G5_9EURY/48-128 .yfa------------------------.-.--------------------------------RDLEIGDAKLKTTVKIGKLFVGIS......KASAEDEIRSICDDLFT...FPYHLHVGR..FSKDRPTIVDVLG----.........------------------kssykrigvlekrsn
MCRW_METTH/9-157 ....DVKIFPQRLLKPETAEKLLNRIYE.L.EGIVRVLVHGPSIPDRVYYGPARGTEVNHSDRRKITVRGEEFELRVKVGEIIVGMLp...etLEEKMETIEEILDEVLP...CSYKVFIGA..FTKKDITISDYLKYGLKfe.....ekIDPRVIGMVDPSSRMKD-t..............
F4BXY3_METSG/11-152 ....QVEITPQRYLMPATAQKLLNAIYE.N.GGITRIMIHGPNLPRTIPYGPGKGTPIDEHKDLLIEVAGQVFELGVKVGRVRLELE......SEKYMPGLEAACERALP...FSFQIKRGR..FFRNSPTLSDYAKYGDV.........EDKRLLGLIDPKARKE--kl.............
A0A0X3BM21_9EURY/8-149 ....QVRIVPLRMLKPETTERLLNTLAG.I.AGIRRMMIHGPGLPATVPYGPARGSPNPHSDRRAIHVGDAEIALRIQAGEVILEVE......DSSVIEEIRSHCDDFFT..eFPYQLQEGR..FMKTAPTLVDYAKFGPD.........ADTTLIGLADPRS-----gedp...........
R9TBQ1_METII/13-137 ...e-ILIFPARMLSAGTTEKLLNNIYE.V.PNVRQVNISGEALPAVVGNGPAKGTLVNHPERKVINVKGREYELNLLVGRVFVEINdi..dnVDKAVEEIKKICDDLLP...FGYNLEVGR..YSKFQPTITDYKK----.........------------------m..............
A0A0Q4B337_9ARCH/4-130 ....EIRITTKRLLGAESTEKVLNALSA.L.DNIRQITIKGENLPAKINSGPNKGLDNNHPERRMIRFGDKDILLTKLVGDFFLELEvenedmLSASVEEIDRICKEVIP...FGFTMDVGR..YSKYRPTLSDY------.........------------------klr............
E3GZ54_METFV/2-135 ....DVEIFPHRLLSAETTEKLLNKLGE.I.EGIKRMIIQGQRLPAG-----------EHPDRRVINVKGQDIELKVKTGRIFVEIE......DKKTMEKIKEVCDEVFP...FKYELIPGT..FFRRQKTVTDAIKFGKDv......dkLPTELVGMTDQSARLKD-r..............
E1RDX7_METP4/10-152 ....QCKIVPIRMLSPETAEKFLNLIVR.V.KGIRRFVINGPSLPKTVPYGPARGKPNPNSNRRVIQIGDTETELRVQVGVIILEVE......ERSVIDEIRKVTSEFFEg.kFSCQVMEGK..FMKTEPTTSDYAKYGPN.........ADEMILGLVDPRKKE---gp.............
U6EEL5_9EURY/8-156 ....DVRIFPHRRLKPETTEKILNALLD.L.EGVLRFLVNGESLPKIVGYGPARGTSVDHPDRKIITVKGKEVELLVSVGEIIVTIRq...enLEEFVEKTKAILEETLD...FGFDVQVGI..FTRQQATVSDNLKVAYGie.....edFDPRLIGLVDPKDNSNE-t..............
A0A1D3L4R9_9EURY/2-136 ....DIEIFPHRLLSADTTERLLNDLEK.I.EGVERMVLHGQRLPQG----------SDNPDRRTIKINGEEVELQIKTGRVLMEID......SEETIDEVREICEEHLP...FGYNIHMGL..FIRKQKTVTDQIKYGEKl......eeVSEDMIGLTDQNAKLSE-r..............
A0A1D2WB23_9EURY/2-137 ....DIEIFPHRLLNVDTAERLLNDLDS.I.EGIKRMIIHGPRLPPV------R---EGHPDRRIIVVSGEEVEVQVKPGRILLEIE......SEDVIEDVKEVCEDHLP...FGYNIHIGH..FIRKQKTVSDQLKYGEEl......dnIPDEMVGLTDQNAQLSE-r..............
MCRW_METFV/11-160 ....DVKVVPYRLLNPQTVETILNKIYD.L.DGIVRVLVHGPSIPKEIPYGPAKGIKVNHKDRQVIKVKGEEVELKVKVGEIIVGVLcd..dkMDENIGKIEKIMDENLP...CSYQMWVGT..YTKRDVTVTDWMKYGPKfe.....kkLDPRYIGLVDPNSKVKE-n..............
A0A0W7TIG7_9ARCH/1-122 ...m-----TNRLLSAETTEKVLNAIDS.I.EHIRQINMGGESLPKTISSGPAKGAENNHSERRIINVNGHEVELRCEVGAFYIELEvddkdmLEATVEKIKDAFDATVP...FGYTIEIGR..YTKYRPSLHDY------.........------------------rs.............
R9SP78_9EURY/2-142 ....DIEIFPHRMLGPDTTEKILNDIES.L.EDVNRTIIHGPRLPPDDPDLLPQ-----YKERREIVVKGQPITLKVKTGRILVELT......SESTINEIDKICSEYLP...FGYDINTSRreYIRKQRTVSDAIKYGPDd.......nLPDELVGMTDARRQMAD-d..............
A0A166A6P3_9EURY/2-139 ....DIEIFPHRILGSDTTERLLNEIEG.L.EDVNRTILQGPRLAPESPDDDP-----RYAERRIITVQGKEIELKVKAGRIFVDLS......EESTIDQIREICNEILT...FGFDINIGT..YIRTQKTVTDSIKYGNA........eLPDELIGMNDQYSMLE--dr.............
A0A6B9T9X5_9ARCH/18-143 ....EVQILTNRLLSAETTEKVLNALDI.I.PNIRQINMTGESLPKTINSGPGKGLPNNHSERKVIHVGGQEVELRYLVGGFYIELDvedeetLDKRLEEIKEACNATIE...HGYTLQVGR..YSKYKPTLHDY------.........------------------rs.............
A0A1V6N4G6_9EURY/2-139 ....DIEVFPHRVLGADTTEKLLNGIES.L.DDVKRTVIQGPRLPPE---DPNED--PRYVDRRKITVNGKELELKVKTGRIFVEIS......NESTIDDIREICNEYLP...FGFDINIGK..YIRTQKTVSDNIKYGDA........dIPEELIGMTDQSAKLAD-r..............
D5EAD9_METMS/13-154 ....QIEIFPKRMIKPDTVEGLLNKLCS.L.EGIQRAFIQGPRLPTKVPFGPAVGTPVHHPSRTNVHFGKTEMGLEVLVGRITLELA......GKEIMEEINAICEDTLP...CGYDIREGR..FIQTRQTVSDYAKRGPT.........ADPALYGLYDPKSKVES-q..............
Q8THG8_METAC/13-154 ....QIEIFPSRILSPETAQKLISELYQ.V.DGIIRVMVQGPRLPERVSAGPGTGEKVEHPLRKPIQIGDQVIELKISVGRIRLEIE......NAETKEKVRSVCDKMLP...FSFEFREGH..FLRRKPTVTDYAKLGPE.........TDPRLLGMVDPKAKVN--ql.............
D3E053_METRM/2-141 ....DIEIFPHRILGTDTTEKVLNDLES.L.DSVKRTVIQGPRLP------PQDEIDRIYGDRRIIVVNGEEVELKVKTGRIFVELY......DESGIEEIRAICDKHID...TGFDINTSKaqYIRKQKTVTDGLKYGENt.......eIPEELIGIADTRSKFNE-h..............
A6UWG9_META3/3-148 ....EIEVFPHRFLKADTTEKFLNDIYS.I.ETVERVIVHGQPLPKTVYYGPARGTPVNHPERKEVLVNGVPVELTVMAGRFWILLE......NDNELNKIEEICKSLFP...YGYNLNVGK..FTRDSPTTTDYMKYGEKlv.....nsMDRKMIGLTDPRSKFAS-s..............
A0A484F515_9EURY/20-161 ....QIEIVPQRILSPDTSEILLGRIYD.C.DGIIRVMVQGSRLPDKVGYGPGTGEKVDHPLKKSIEVEGQQVNMRVTLSRLLIEVD......SDRTADEIKKICDETFS...FPFEFYKGV..FFKKYSTVVDYAKMGPE.........PDERLLGMTDPKGKLD--qi.............
F0T8R0_METLA/2-136 ....DIEIFPHRLLNPETTESLLNALDE.I.DGVKTIVLQGQRLPPE----------AINSDHTTITVKGEEVDLQVKTGRVLMEID......TEDTIELVRQKCEENLS...FGFNVHVGT..FIRKQKTVSDKIKYGEAl......enVPDEMVGLTDQNALL---ser............
F6BBJ0_METIK/10-159 ....DIKIFPHRYLKPETSEKVLNAIYD.LgDDIIRVIVHGPSLPKYVYYGPARGMPVNHSDRKVIKIKGEEVELTVKVGEIIVTVPf...ekAMEIEKKLHKICKENFP...YGYDIYVGA..FTKVRPTVTDYLKYGERfv.....neVDKRLIGITDPRSKFES-a..............
W9DQG9_METTI/12-153 ....QLEIFPSRLLKPETAQNLLSEIAE.V.EGIIRLFVHGPRLPQTVPYGPATGMPVNHPGNAVIEVAGQAIELAVSVGSIRMEVV......DVDVKEQVREVCEKVLT...VPFEFREGR..FIPTRQTVSDYARRGPN.........ADPLMTGMTDPKGKLKN-n..............
A0A1Y3GAR2_9EURY/4-138 ....QVQIFPDRLLLGDTASEVITQLSE.I.DEVREIVVTGPRIPKRVPYGPAKGIENPHTERKKLKIMDKETDLEVKVGRIILDLDae.dddVDPIIGDITEICDIKIS...CDYNIETGQ..YTKPKPTVTEYMRYGKK.........PDKE--------------nk.............
Q0W342_METAR/13-153 ....QIEIFPERLLNIETAQALLNELNK.I.GGITRMIVYGPRLPKDDPKDLLDGK-FDAREKKFLDIMGEKIELTVQVGRIFVEIE......NPGVKDKINEACRKTLP...FPFEINEGL..YIRTQKTLTDYVRKGGK.........VDDISVGMSDPGAM----qkys...........
L0HF34_METFS/10-152 ....QCRIVPMRLLSPDTTKRLLERIVP.V.PGIRRMLLNGQNIPVVVPYGPARGTANKTNLRKSIEIAGNTVDLHVQVGTITLEVE......DKSVIAAIRAICDNYFV..nFPCSVQEGR..FMKTRPSLVDYAKYGPE.........ADPSVIGLVDPKRKEK--pa.............
Q2NI01_METST/20-168 ....DVKIFPDRILKPETTETILNKVMK.L.EGVLRILINGERLPTVVTMGPARGAPVNHTDRKTINVKGNDVPLRVSVGEIILTVQl...dnLEDFVTEVNNILDETLK...FGYNVSVGV..FTKTNTTVSDYMKYGQGfe.....dkIDSRLIGLVDPNAKSSE-t..............
G7WN22_METH6/11-153 ....QIEIFPQRFLKPDTAQRLLEEIYS.S.GGILRIMIQGPNLPKSVPYGPGKGIPIEEHLNMLLELGDSALELRVKVGRIWLELD......SEERIEGVKAACERVLP...CTFSIKRKQ..LFHTKPTVSDYAKYGSE........vEDKRILGLVDPKAKRE--rd.............
M9SHS0_METAX/15-140 ....EVRIMTNRLLSAESTEAVLNAIDK.I.EHIRQVNMAGESLPATISSGPAKGLPNNHTERKIIHVDGREVELHCLVGAFYIELEvddsdmLEAVVKEIREACDKTIV...DGYTLDIGR..YSKYRPTLNDY------.........------------------rs.............
A0A062V6Q2_9EURY/13-163 ....QIRIFPQRLLQPETTEKVLNDIDQ.V.KGVIRMLLNGKNLPRKVTSGPGTGADVNHPDRKIINVGDCAFELHIIVGEILVEVE......NEGAMEEVREACERTLP...FPFEFRRGH..FIKRKPTLTDYGKYGFRsrnderinlEDERIIGLTDPHAKTED-n..............
A0A1F2P4Q0_9EURY/50-129 nyls------------------------.-.--------------------------------RHLRVGEQKIHTTVKVGKIFIGIS......KESTIDEIKGVCDDILA...FPYDLAVGR..FSKTRPTVSDALGKSS-.........------------------yrdigildrk.....
A0A328S3N1_9EURY/15-163 ....DVKIFPHRILKPTTTEKILNQILQ.L.DGLLRVLINGKSLPAIVTFGPAKGLPVNHTDRKTINVKGNDVPLRVSVGEIILTVQl...dnLEDFVEKVDEILNETLS...FGYDVKVGI..FNKTQTSVSDYMKYGEGfe.....dkIDSRLIGLVDPNAKSSE-t..............
A0A2V2MWE9_9EURY/8-150 ....QCRIVTERLLKPETVEKILNKLVA.I.EGIRRIVINGPSIPQLVPYGPARGLPNPHSGRVRIVVGGTDVDLRVQVGTILLELE......TRDIVPRIDEACREVFV..nFTYGLKEGK..FMRSTPTQTDYAKYGPG.........ADEMMIGIVDPKNKT---gpt............
L0KYV7_METHD/13-154 ....QLEIVPQRLLRPETAQDLLNKILD.L.EGVIRLFIHGPRLPGTVPYGPAKGTALVHDSRRLIEIEGKAVELMVSVGSIRLEVT......DADVKEQVHEICEKILP...FPFEFREGN..FMLRRQTVSGYARFGPD.........QDPLLVGMTDPKGKLKD-q..............
A0A328PI59_9EURY/2-137 ....DIEIFPHRLLGADTTEKLLNDLEE.I.ESIKRMVIQGQRLP------PAE---EGHPDRRMIKISGQEVELQVKPGRVLLEVE......DESAIDDIKKVCEEHLP...FGFEVHIGK..FIRTQKTVTDELKYGELl......deIPDELIGLTDPNARLTE-r..............
F0TCV3_METLA/8-156 ....DVKIFPYRRLKPQTTEKVLNGIME.F.DGVLRVLVNGNSIPKVVNYGPAKGTPVNHEDRKVIGVKNENIELCVSVGELIITVNy...deLESFMEKLDTLLKETLT...MKYDVKTGI..FTKTDITVSDYIKIGLGle.....ngIDPSLIGLVDPNSKSSE-t..............
Q12TF5_METBU/13-154 ....QIEICPARFLSPETAQRLLNELSN.I.EGITRAFVHGPRLPKTVPYGPATGHDVDHKFSKNIQIGETDMDLAVIVGRIRLEIL......NEEIRENIREVCERTLP...MGYEFRQGL..FIQRRQTVSDYAKRGPG.........ADPTTLGLADPKGKVG--nr.............
A0A1D2W9X6_9EURY/8-156 ....DVKIFPHRLLKPKTTEKILNSIID.L.DGILRVLVNGKSLPRVVGYGPAKGTIVNHEDRKVIKVKEENFELLVSVGEIIVTVNh...ekLDSFKEELERILSDALN...FRYDVSVGI..FTKTNITVSDYMKYGIGfd.....ksIDPRLIGMVDPSAKSSE-t..............
A0A166F276_9EURY/2-139 ....DIEIFPHRVLGADTTEKLLNGIES.L.VDVKRTVLQGPRLPPE---DPNED--PRYFDRRRITVNGKEIELKVKTGRIFVELS......TEETIDEIKVICEQHLP...FGFDINIGK..YIRDQKTVTDNIKYGDA........dIPDELIGMTDQSAKLKD-r..............
F6BE94_METIK/3-148 ....EVEVFPHRYLKATTTEKFLNKVYA.L.ETTERIIIHGQPLPKTVYYGPAKGTPVNHSERKIISVGGVPVELTVMAGRFWITLK......DDSELDKLKEICEELFP...FGYNIKVGK..FLKDKPTVTDYIKYGERfv.....neIDKRLIGITDPRSKFES-a..............
A0A1F2P4Q0_9EURY/14-52 ....EVVIIPERLLGDETTEKLLERFQA.I.DGIVNIILQGPN--------------------------------------------......-----------------...---------..-----------------.........------------------yl.............
D1YW09_METPS/17-157 ....QIEVFPQRLLNIGTAQKLLNELNT.I.EGIIRMVVYGPGLPRDDPDDLLEGK-FGVAEKKYFNIMGEMVELSVQVGRIWIEIE......DTKAIEKIREACEKALP...FPFELNEGL..YLRRKKTVSDYARRGPN.........VDDMSLGMFDPKVKRE--pa.............
A0A2Z4L887_9EURY/15-163 ....DVKIFPYRILKPETAESILNEVMV.L.DGVLRVLINGESLPTVVNFGPARGLPVNHTDRKTINVKGNDVPLRVSVGEIILTVQl...dnLEDFVEKVDEILENTLS...FGYDLKVGV..FTKTQTSVSDYMKYGKGfe.....dkIDSRLIGLVDPNAKSSE-t..............
I7J9I9_METBM/8-150 ....QVRIVSARFLRPDTVEQLLNRLVQ.V.GGIRRMSINGPSLPATVPYGPARGKPNPHPDRKAIRVGNQDVQLQVQVGTIILELE......DESYIPAIGEAVDEVFAekdFSCTVQQGR..YMKTRPSMSDYARYGPD.........ADREILGIVDPRRK----dg.............
I7KD24_METBM/51-192 ....QVRIVPLRMLKPETTERLLNTLAG.I.AGIRRMMIHGPGLPATVPYGPARGSPNPHSDRRAIHVGDAEIALAIQAGEVILEVE......DSSVIEEIRSHCDDFFT..eFPYQLQEGR..FMKTAPTLVDYAKFGPD.........ADTTLIGLADPRS-----gedp...........
A0A483CYB8_9EURY/8-149 ....QCRIVPARFLNPETVENLLNRFLE.V.GGIRKLVLNGPRLPTTVPYGPARGQPNPHQMRRVIRVGDQDVELQVQVGTILLELE......DRSYIDGIKKACEEVFV..kFPFGFSEGK..YMKTEATVSDYAKYGPD.........ADKMFLGTTDPKSRS---gp.............
A0A110A3F8_9ARCH/15-140 ....EVRVMTNRLLSAETTEKILNDIDV.I.PNLRQINMSGESLPRTISSGPAKGLANNHTERKVIHVNGHEVELHCLVGAFYIELSvtdeaeMDKTVDEIKAAFDRTIP...DGYTIDVGR..YSKYRPSLHDY------.........------------------rs.............
A0A2U1S6W9_9EURY/2-141 ....DIEIFPHRVLGSDTTEKLLNEIEA.L.NDVKRTVIHGPRFPANEETLPPK-----FRERRVININGEDVILKVKTGRIFVELT......MESTIKQIDEICKKHIP...YGYDINQDKsnYIRKERTVSDRIKYGEA........dLPDELIGMTDQYSSFED-h..............
A0A1Q6DVN8_9EURY/3-126 ....EVQIFPEKLLLAETTKELATKLSK.I.NEVEEILVHGPTLPKKVPYGPAKGKDNPHSERGKLQVRGEEVELNVQVGRVFVRVDes.kssLEDILEKLVDVCEETIS...CGFDIGQGR..FEKKESS----------.........------------------segnm..........
B8GE90_METPE/8-149 ....QCRIVPERLLNPSTVERLLNLLVT.I.ESIRKILIKGSSIPPAVPYGPARGALNPHSMRRTIMVGEQPVELTVHVGIIDMELE......DRDALPQIKAACEEVFT..qFTYSIKEGR..FMKTQASTSDYAKYGPD.........ADELLLGLADPKSRK---gp.............
D1YVW3_METPS/13-152 ....QLEIFPSRLLTVETAQKLLNELNK.I.SGITRMVVYGPGLPKDDPKDLLEGK--FEAQKRYLNILGEQVELTVQVGRVWVEVE......DIAVKDKIREACEKTLP...FSFDINEGL..YLRTRKTITDYVRKGGN.........VDDISLGMFDPKSRRK--ps.............
MCRD_METJA/5-153 ....EVEIFPHRYLKASTTEKFLNKIYD.L.KTVERVVIHGQPLPKVITYGPARGLPVNHTERKIIHVKGVPVELTVMAGRFWITLS......DDSELDKLDEICKEMFP...FGYNLRVGK..FLKDRPTVTDYIKYGEDgvf..lineMDRRLIGMVDPRSRMAN-s..............
F1SVE8_METKA/13-163 ....EVQIFPQRLLSADTTEKLLNELLErV.EGIGRIVIHGPGLPKAVPFGPARGKPVKHPERRPIEVHGEKIPMKVQTGQIIVEIEde..drLDDIVEEIEKICREILP...CDFEVQVGR..FTRHKPTVTDYLKFGEEgv.....kkLDKRLLGLVEPRARLAD-r..............
MCRW_METJA/16-162 ....DVKIFPHRYLKAETTEKVLNEIYD.L.DGIVRVIVHGQPLPKTVPFGPARGLPVNHQDRKVIKVKGEEMELRVKVGEIIITVEg...ekLEKIMDGIEEICKRNFP...FGYDIYVGA..FTKIKPTVTDYMKYGDIs.......sIDPRLIGMVDASARLKD-s..............
A0A4E0PYS3_9EURY/12-153 ....QLEIFPSRLLRPETAQNLLNEIAE.I.EGVTRLFVHGPRLPQNVPYGPAKGEPVQHPGNKVIEVAGQAMELAVCVGGIRMEVI......NVDVKEQVREVCEKILP...VSFEFRQGH..FIPTKQTVTDYAKRGPG.........ADPLMIGMTDPKGKLKD-y..............
A0B6N8_METTP/14-155 ....QVEIFPSRFLSPETTQKLLNELYK.S.GGIVRMMIQGPNLPRTVTYGPGKGLPIEEHRNLLVEVGGEVLELRVKVGRIRLELE......GEEFLPGIEAACERALP...FSFQIKRGK..FFRDISTISDYAKYGKD.........ADKRILGLVDPRAKKES-a..............
F7XL11_METZD/12-153 ....QVEIFPKRLLGPEKAQKLLNELSN.I.DGILRAVIQGPRLPLKVPYGPATGEDVHHPDRKVVQIANTTFELSIMVGRIRLELA......NTDVKEKVRQVCEKMIP...FGFEFREGT..FIAKRSTVTDYAKRGPD.........ADPTLRGLFDPKAKIDE-q..............
A0A0Q4B5G7_9ARCH/13-139 ...e-VLIFPHRLLSADTTEKLLNRVYE.V.PHVRQINVSGEGLPAKVTSGPHAGLPVEHPQRKVITVKGKEVELTLQVGRIFVEIDdi..dnLQGALDEIEKICQEILT...FGFNLEVGR..YSKYRPTVTDYKK----.........------------------gkr............
Q0W5P0_METAR/19-159 ....QIEVFPLRVLNVETAQKLIDELNK.I.DGITRMVVHGPRLPRENPDDLLEGK-FGATDKKYLNIKGEQVELTVQVGRIWIEIT......DTPVIEQVRAAAEKTLP...FPFEMYEGV..YIRTKKTLSDYVRKGGN.........VDDISVGLFDPKAKARS-s..............
A0A2V3JKK1_9EURY/11-154 ....QYEIFPQRMLDPSSAQELLNRLEQ.I.EGVTRVLVQGPRLPLTVPSGPGKGVPVDHQAREVIRVGDQVMELQVKVGRIRLEAE......-NDVMEEVRALCEELFP...FPFELKEGL..FLRRKATVTDYAKYGPDe......mvEDKDIYGMTDPNM-----sptak..........
Q6LWZ8_METMP/3-148 ....ELEVFPHRYLKAETTEKFLNRAYS.L.SKVQRVVIHGESLPNKVGYGPAKGTPVNHSEKKEITVKGVPVELMLQVGRLWVLLD......DESEIEKIEEICKDLFP...FGYRLTKGK..FLRNDPTVSDFIKYGESav.....ddIDKRLLGATDPRSKFDS-s..............
MCRD_METTH/2-135 ....DVQIFPHRLLGADTTEKLLNRLED.I.SGVKRMVIHGQRLPPE-----------DHPDRRIISVKGHEFELQVKTGRVLLEIE......DEDTIADIKRVCEDLLP...FGYDVTPGK..YIRTQKTVTDEIKYGEDl......dkVPEELIGLTDQNARLSE-r..............
Q8PXH5_METMA/13-154 ....QIEIFPSRILSPETAQKLLVELSQ.V.DGILRVMIQGNRLPEKVGYGPGTGEKVEHPLRKPIQIGGQVIELRVSVGRIRLEVL......NAEVKENVRAVCEKMLP...FSFEFREGH..FLRRKPTVTDYAKLGPE.........ADPRLLGMVDPKAKIN--ql.............
D7DUH2_METV3/3-148 ....EIEVFPHRFLKATTTEKFLNSAYK.L.ETVQRVILHGESLPQKVGYGPAKGAPVNHSERKLINVNGVEVQLTLQVGRFWILLD......NENELSKIDEICNELFP...FGYRVSEGR..FIKDSPTVTDYLKYGESfv.....nsIDKRMLGVTDPRSRFEN-s..............
A0A483CQJ0_9EURY/8-149 ....QCRIVPLRLLSPQTAEKFLGRCAE.V.PGIRRIVINGPGLPATVPYGPARGSANPNSNRRTIQVGGAAVEMKVQAGTFILEVD......DEGVIEEIRTVCDEFFT..aIPYRLQTGR..FMKSSPSLVDYAKYGPN.........VDEAVVGLVDPRKR----dgp............
A0A366M859_9EURY/2-139 ....DIEVFPHRVLGADTTEKLLNGIEG.L.DDVKRTVLQGPKLPPA---DPNED--PKYADRGIIIVNGKEIELKVKTGRIFVEIS......NESTIDDIREVCDEYLP...FGFDINIGK..YIRTQKTTSDNIKYGDA........dIPDELIGMTDQSAKLAD-r..............
L0HJW7_METFS/8-149 ....QCRIDSERFMNPETTERLLNQIIS.V.PGVRRMVLNGPRLPATVPYGPSKGIANPHPMRKTIRVGDQEMELQVHVGTVLLELE......NRDIIPALKAAIEPVFK..dFSFHMKEGR..FMKTEPSLVDYCKYGPD.........ADKEILGLADPNSKS---rp.............
A0A328S7V5_9EURY/9-157 ....DVKIFPHRILKPQTTENILSQILE.L.DGVLRVLINGKSLPTMVNFGPAKGLPVNHTDRKTINVNGNEVPLRVSVGEIILTVQl...dnLEDFVTQVDRILEESLN...FGYDLDVGI..FTKHATSVSDYMKYGEGfe.....dkIDSRLIGLVDPSAKSSE-t..............
A7I5U2_METB6/8-150 ....QCRIVTERLLNPETTELLLNRLVD.I.PGIRRMVLNGPRLPAIVTYGPAKGMPNPHSMRRAIHVGDQDMDLQVHVGTVLLEVE......SRDVIPALKAACEEVFT..hFAFRIQEGK..YMKTEPSLVDYCKYGPD.........ADKSVLGLADPSSKSR--pt.............
A0A166CF39_9EURY/2-139 ....DIQIFPHRILSADTTELVLNKIEA.L.DDVHRTVINGPRLPPEDLDLPPQ-----YREKRTINVQGKEIDLKVQTGRIFVEIS......QESTIDEVKNICQDAFP...FGFEINIGK..FMRTQKTVTDHMKYGDE........kIPDEYIGMTDQSAKLSD-r..............
U6EC36_9EURY/2-136 ....DIEIFPHRLLSADTTEKLLNNLEG.I.EGVKRMVIQGQRLPQT----------EDNPDRRVITILGEEIDLQVKTGRVLLEIE......DESVIEQVKSICEDQLP...FGYNIHVGT..FIRKQKTVTDDIKYGEAv......deIPDEMIGLTDQNAQLSE-r..............
M4YM91_THEXX/1-123 ...m-----TNRLLSAQSTEAVLNAIDD.I.EHIRQVNMSGENLPATINSGPAKGMSNNHTERQIIHVGQQEVELHCLVGAFYIELEvddkdmLEATVDKIKAACDEHIK...DGYSLEIGR..YSKYRPSLTDY------.........------------------rsa............
H1YXI2_9EURY/10-149 ....QCRVVPLRMLSPDTTEIFLDKVVK.V.KGIRRMTINGPSLPKTVPYGPARGKPNPNTNRRTIQVGDSEVELRVQAGMFVFELE......DEGVTENIRAVCDEVFT..kFPYQLQVGK..YMKTSPTLSDYCKYGPD.........ADEKMVGLSDPRK-----dg.............
A2STS2_METLZ/8-150 ....QLRIVPTRFLNPETTEILLEKIYT.I.DGIRRLVLNGPNLPATVPYGPARGTVNDNSLRRIIKVCGEDYLLHVQVGAILLELE......DASVIPLVKAACDEVFAd.kFPYGITEGT..YMRSNMTTTDYAKYGIV.........DDKRILGMSDPKSKQ---rp.............
#=GC seq_cons ....plcIFPpRlLps-ToE+lLNcl.p.l.cGlpRhllpGspLPtpVshGPu+GhsssHs-R+hIpVsGp-lELpVpVGcIhlElc......s-ssl-cl+clC--hls...Fuaplp.G+..Fh+ppsTloDYhKYG.t.........hDpphlGhsDPpu+.t..p..............
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