#=GF ID   MS_channel
#=GF AC   PF00924.18
#=GF DE   Mechanosensitive ion channel
#=GF PI   UPF0003;
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF AU   Martinac B;0000-0001-8422-7082
#=GF SE   Pfam-B_1136 (release 3.0)
#=GF GA   21.00 21.00;
#=GF TC   21.00 21.10;
#=GF NC   20.90 20.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 45638612 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   11296222
#=GF RT   Structural and functional differences between two homologous
#=GF RT   mechanosensitive channels of Methanococcus jannaschii. 
#=GF RA   Kloda A, Martinac B; 
#=GF RL   EMBO J 2001;20:1888-1896.
#=GF RN   [2]
#=GF RM   11159397
#=GF RT   Molecular identification of a mechanosensitive channel in
#=GF RT   archaea. 
#=GF RA   Kloda A, Martinac B; 
#=GF RL   Biophys J 2001;80:229-240.
#=GF RN   [3]
#=GF RM   11275684
#=GF RT   Mechanosensitive channels in prokaryotes. 
#=GF RA   Martinac B; 
#=GF RL   Cell Physiol Biochem 2001;11:61-76.
#=GF DR   INTERPRO; IPR006685;
#=GF DR   PROSITE; PDOC00959;
#=GF DR   SCOP; 1mxm; fa;
#=GF DR   TC; 1.A.23;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   Two members of  this protein family: Swiss:Q57634 and
#=GF CC   Swiss:Q58543 of M. jannaschii have been functionally
#=GF CC   characterised. Both proteins form mechanosensitive (MS) ion
#=GF CC   channels upon  reconstitution into liposomes and functional
#=GF CC   examination by the patch-clamp technique. Therefore this family
#=GF CC   are likely to also be MS channel proteins.
#=GF SQ   24862
#=GS A0A1G3H4X2_9GAMM/161-272    AC A0A1G3H4X2.1
#=GS A0A1I2YEG6_9SPHI/137-337    AC A0A1I2YEG6.1
#=GS A0A1F9KT13_9DELT/130-335    AC A0A1F9KT13.1
#=GS A0A1E5E6L3_9VIBR/83-285     AC A0A1E5E6L3.1
#=GS A0A0D6P7Z0_9PROT/113-312    AC A0A0D6P7Z0.1
#=GS A0A246FYU6_9PSED/160-272    AC A0A246FYU6.1
#=GS A0A1G7MQI5_9EURY/106-320    AC A0A1G7MQI5.1
#=GS I3DGW5_HAEPH/876-1076       AC I3DGW5.1
#=GS A0A1B7GNJ4_9BACT/57-194     AC A0A1B7GNJ4.1
#=GS A0A177V191_9BASI/659-864    AC A0A177V191.1
#=GS A0A1L9QVL4_9CYAN/324-526    AC A0A1L9QVL4.1
#=GS B5IQB8_9CYAN/310-515        AC B5IQB8.1
#=GS A0A0R0CWE3_9GAMM/573-773    AC A0A0R0CWE3.1
#=GS V9VQL1_9RHOB/561-760        AC V9VQL1.1
#=GS G7J8E6_MEDTR/544-751        AC G7J8E6.2
#=GS A0A0P7ZCN0_9BACT/102-302    AC A0A0P7ZCN0.1
#=GS A0A0Q6C912_9RHIZ/633-832    AC A0A0Q6C912.1
#=GS A0A0F2JHI8_9FIRM/73-273     AC A0A0F2JHI8.1
#=GS A0A1S6U789_9PROT/265-497    AC A0A1S6U789.1
#=GS A0A0A0LHK4_CUCSA/475-682    AC A0A0A0LHK4.1
#=GS R6P9G8_9CLOT/73-274         AC R6P9G8.1
#=GS A0A151END6_9EURY/58-271     AC A0A151END6.1
#=GS A0A1G9LP81_9RHOB/340-533    AC A0A1G9LP81.1
#=GS A0A062U0H8_9RHOB/182-384    AC A0A062U0H8.1
#=GS A0A1Q9A9U1_9RHIZ/534-735    AC A0A1Q9A9U1.1
#=GS K9TCD6_9CYAN/214-412        AC K9TCD6.1
#=GS A0A0C1Z5Z0_9DELT/133-334    AC A0A0C1Z5Z0.1
#=GS A0A244CKZ4_9GAMM/145-383    AC A0A244CKZ4.1
#=GS A0A1H7N378_9RHOB/175-377    AC A0A1H7N378.1
#=GS A0A1H7UYY3_9FLAO/64-262     AC A0A1H7UYY3.1
#=GS A0A1H9TUI7_9RHOB/550-749    AC A0A1H9TUI7.1
#=GS A0A146FVF4_9EURO/500-707    AC A0A146FVF4.1
#=GS A0A0N1IS38_9ACTN/135-336    AC A0A0N1IS38.1
#=GS M7TDS7_9EURY/78-200         AC M7TDS7.1
#=GS A0A0M8Y953_9PSEU/113-311    AC A0A0M8Y953.1
#=GS A0A090N3U6_OSTTA/507-700    AC A0A090N3U6.1
#=GS A0A1B9Y087_9FLAO/145-402    AC A0A1B9Y087.1
#=GS A0A0A1VNG9_9BURK/58-182     AC A0A0A1VNG9.1
#=GS B7RK90_9RHOB/556-757        AC B7RK90.1
#=GS A0A101DMT2_9EURY/57-256     AC A0A101DMT2.1
#=GS A0A091BCM8_9GAMM/896-1096   AC A0A091BCM8.1
#=GS W4TIC0_CUTAC/50-249         AC W4TIC0.1
#=GS E6WTB1_PSEUU/58-191         AC E6WTB1.1
#=GS A0A150XIB2_9BACT/62-268     AC A0A150XIB2.1
#=GS A0A133YYM4_9ACTN/64-209     AC A0A133YYM4.1
#=GS A0A166EHI6_9HOMO/622-852    AC A0A166EHI6.1
#=GS A0A1W6MJ21_9FLAO/74-277     AC A0A1W6MJ21.1
#=GS C6HVG0_9BACT/73-274         AC C6HVG0.1
#=GS A0A1F6LIW5_9BACT/143-344    AC A0A1F6LIW5.1
#=GS A0A2A2F6E6_9GAMM/47-245     AC A0A2A2F6E6.1
#=GS A0A165S1E7_9MICO/95-297     AC A0A165S1E7.1
#=GS V2J9A5_9BURK/137-338        AC V2J9A5.1
#=GS A0A0S4L6L3_9BACT/54-226     AC A0A0S4L6L3.1
#=GS A0A1Q3GHZ0_9BACT/60-274     AC A0A1Q3GHZ0.1
#=GS R6DMY0_9BACE/376-579        AC R6DMY0.1
#=GS A0A1D8T0Q1_9ACTN/114-315    AC A0A1D8T0Q1.1
#=GS Q5SHL5_THET8/134-335        AC Q5SHL5.1
#=GS A0A1Z9TB51_9BACT/64-262     AC A0A1Z9TB51.1
#=GS A0A0M5MFY6_9NOSO/318-521    AC A0A0M5MFY6.1
#=GS A0A0M2VIU5_9GAMM/61-259     AC A0A0M2VIU5.1
#=GS A0A239EX27_9BACT/62-260     AC A0A239EX27.1
#=GS A0A1G6XJP3_9BURK/51-264     AC A0A1G6XJP3.1
#=GS A0A1T5FX49_9BACT/58-256     AC A0A1T5FX49.1
#=GS A0A081ESZ4_9EURY/53-256     AC A0A081ESZ4.2
#=GS A0A0D0F7J1_9FLAO/150-407    AC A0A0D0F7J1.1
#=GS L1M5D7_PSEPU/58-184         AC L1M5D7.1
#=GS C9R8D1_AMMDK/135-333        AC C9R8D1.1
#=GS A5WE93_PSYWF/63-261         AC A5WE93.1
#=GS E6WKQ0_PANSA/301-504        AC E6WKQ0.1
#=GS A0A2H4VXX0_9PSED/498-699    AC A0A2H4VXX0.1
#=GS A0A072V2K7_MEDTR/510-717    AC A0A072V2K7.1
#=GS A0A0C1GYU1_9RHOB/504-704    AC A0A0C1GYU1.1
#=GS A0A1W9LAA5_9GAMM/740-942    AC A0A1W9LAA5.1
#=GS A0A1I2QGC9_9GAMM/47-245     AC A0A1I2QGC9.1
#=GS A0A0W1L7H2_9GAMM/44-166     AC A0A0W1L7H2.1
#=GS A0A246J8H6_9BURK/66-181     AC A0A246J8H6.1
#=GS A0A167K9N8_9GAMM/122-327    AC A0A167K9N8.1
#=GS A0A1H4LIE6_9MICO/131-344    AC A0A1H4LIE6.1
#=GS A0A1I7J6N2_9CLOT/60-258     AC A0A1I7J6N2.1
#=GS A0A1I5L5T0_9SPHN/144-343    AC A0A1I5L5T0.1
#=GS Q2G117_STAA8/75-278         AC Q2G117.1
#=GS A0A1F8TMI2_9CHLR/58-243     AC A0A1F8TMI2.1
#=GS A1ZY08_9BACT/143-354        AC A1ZY08.1
#=GS A0A087MJB9_9GAMM/69-275     AC A0A087MJB9.1
#=GS A0A1M5HDD3_9BACT/73-270     AC A0A1M5HDD3.1
#=GS A4SVY2_POLAQ/63-260         AC A4SVY2.1
#=GS F2I079_PELSM/144-351        AC F2I079.1
#=GS A0A1H4FNM2_9BURK/55-181     AC A0A1H4FNM2.1
#=GS A0A0Q7Z655_9SPHN/161-361    AC A0A0Q7Z655.1
#=GS A0A1Z9JBV6_9CYAN/344-548    AC A0A1Z9JBV6.1
#=GS A0A198FKP5_9GAMM/904-1104   AC A0A198FKP5.1
#=GS A0A1R1CK80_9BACL/75-271     AC A0A1R1CK80.1
#=GS A0A0M3C3U7_9SPHI/375-577    AC A0A0M3C3U7.1
#=GS A0A1I2QE50_9CORY/109-311    AC A0A1I2QE50.1
#=GS A0A1I1S5Z3_9FLAO/146-403    AC A0A1I1S5Z3.1
#=GS F0RQV7_DEIPM/138-341        AC F0RQV7.1
#=GS A8UEJ5_9FLAO/59-258         AC A8UEJ5.1
#=GS K9YAC4_HALP7/145-356        AC K9YAC4.1
#=GS E1SDL5_PANVC/70-268         AC E1SDL5.1
#=GS X0R5M8_9GAMM/2-194          AC X0R5M8.1
#=GS A0A0K8LG44_9EURO/460-658    AC A0A0K8LG44.1
#=GS Q5QY88_IDILO/61-259         AC Q5QY88.1
#=GS C5BFN8_EDWI9/117-321        AC C5BFN8.1
#=GS A0A1G1JGM1_9BACT/136-337    AC A0A1G1JGM1.1
#=GS A0A1I6R3V4_9FLAO/290-493    AC A0A1I6R3V4.1
#=GS A0A0F0HN81_9PSEU/132-333    AC A0A0F0HN81.1
#=GS A0A143XNI1_9BACT/149-405    AC A0A143XNI1.1
#=GS A0A218P962_9EURY/57-256     AC A0A218P962.1
#=GS A0A1S8CCZ1_9ACTN/70-269     AC A0A1S8CCZ1.1
#=GS A0A1U7H6V9_9NOSO/319-520    AC A0A1U7H6V9.1
#=GS A0A166EAA4_9HOMO/464-673    AC A0A166EAA4.1
#=GS A0A0N1ESP4_9SPHN/142-344    AC A0A0N1ESP4.1
#=GS A0A014ML17_9BURK/203-404    AC A0A014ML17.1
#=GS A0A1W1I3D4_9BACT/57-253     AC A0A1W1I3D4.1
#=GS A0A0W0V894_9GAMM/203-404    AC A0A0W0V894.1
#=GS A0A133VNQ6_9EURY/63-263     AC A0A133VNQ6.1
#=GS A0A259R4Q9_9GAMM/89-295     AC A0A259R4Q9.1
#=GS A5WBM1_PSYWF/215-417        AC A5WBM1.1
#=GS A0A0V8QA40_9FIRM/68-267     AC A0A0V8QA40.1
#=GS C7DFY4_9RHOB/240-441        AC C7DFY4.1
#=GS A0A0H5BC24_BLAVI/579-778    AC A0A0H5BC24.1
#=GS X1WK67_ACYPI/29-227         AC X1WK67.1
#=GS A0A059CUL9_EUCGR/529-690    AC A0A059CUL9.1
#=GS A0A285KQG8_9ENTR/869-1069   AC A0A285KQG8.1
#=GS E1T7H9_BURSG/216-416        AC E1T7H9.1
#=GS A0A0F4GYV4_9PEZI/493-690    AC A0A0F4GYV4.1
#=GS J2MZD6_9PSED/579-779        AC J2MZD6.1
#=GS A0A1Z5IBW1_9LACO/76-274     AC A0A1Z5IBW1.1
#=GS A0A147GVB0_9BURK/612-812    AC A0A147GVB0.1
#=GS A0A0Q0L163_9GAMM/327-525    AC A0A0Q0L163.1
#=GS C7M448_CAPOD/73-277         AC C7M448.1
#=GS D8P9M8_9BACT/61-173         AC D8P9M8.1
#=GS I4N760_9PSED/107-308        AC I4N760.1
#=GS Q2K8A2_RHIEC/480-681        AC Q2K8A2.1
#=GS A0A2A9HHT1_9CHLR/79-278     AC A0A2A9HHT1.1
#=GS A0A1U8KSR2_GOSHI/629-836    AC A0A1U8KSR2.1
#=GS A0A0C1R1X7_9CYAN/22-125     AC A0A0C1R1X7.1
#=GS C6BTZ1_DESAD/350-550        AC C6BTZ1.1
#=GS A0A0R0A2J7_9GAMM/158-359    AC A0A0R0A2J7.1
#=GS A0A136A2T4_9ALTE/149-405    AC A0A136A2T4.1
#=GS A0A0K9JV04_9BURK/65-260     AC A0A0K9JV04.1
#=GS A0A238UTK2_HALVU/62-265     AC A0A238UTK2.1
#=GS A0A2H3DLD1_ARMGA/501-687    AC A0A2H3DLD1.1
#=GS A0A0P8C8F2_9EURY/146-347    AC A0A0P8C8F2.1
#=GS A0A166SY49_9EURY/108-309    AC A0A166SY49.1
#=GS A0A061D594_BABBI/610-809    AC A0A061D594.1
#=GS D1CAS8_SPHTD/92-292         AC D1CAS8.1
#=GS A3U9H6_CROAH/365-566        AC A3U9H6.1
#=GS M9LKP1_PSEA3/560-744        AC M9LKP1.1
#=GS A0A0J6SE55_9RHIZ/66-266     AC A0A0J6SE55.1
#=GS A0A0D2FEJ5_9EURO/495-708    AC A0A0D2FEJ5.1
#=GS H6RMI6_BLASD/61-152         AC H6RMI6.1
#=GS S6BWL4_LACCA/85-283         AC S6BWL4.1
#=GS A0A1G8YIE1_9GAMM/505-706    AC A0A1G8YIE1.1
#=GS R1H5H2_9GAMM/877-1077       AC R1H5H2.1
#=GS M1P0W6_DESSD/544-747        AC M1P0W6.1
#=GS A0A1G0ZV24_9BACT/138-343    AC A0A1G0ZV24.1
#=GS A0A1H3XNQ5_9DELT/574-774    AC A0A1H3XNQ5.1
#=GS A0A0Q0UX32_9SPHI/560-759    AC A0A0Q0UX32.1
#=GS A0A1T4WG86_9GAMM/488-693    AC A0A1T4WG86.1
#=GS R5F1E1_9BACE/152-407        AC R5F1E1.1
#=GS Q0S6Q3_RHOJR/103-304        AC Q0S6Q3.1
#=GS A0A1I6KLQ5_9GAMM/61-259     AC A0A1I6KLQ5.1
#=GS D4TRU6_9CYAN/108-348        AC D4TRU6.1
#=GS E7RZ66_9BURK/656-856        AC E7RZ66.1
#=GS A0A1G0XDD0_9BACT/230-435    AC A0A1G0XDD0.1
#=GS U7LFA2_9CORY/129-331        AC U7LFA2.1
#=GS A0A0Q0ZJ23_9RHOB/71-269     AC A0A0Q0ZJ23.1
#=GS I2K928_9PROT/292-526        AC I2K928.1
#=GS A0A255D794_9MYCO/116-312    AC A0A255D794.1
#=GS A0A287XNB7_HORVV/17-189     AC A0A287XNB7.1
#=GS A0A259QPQ7_9GAMM/58-188     AC A0A259QPQ7.1
#=GS A0A0Q4V3Y6_9MICO/118-306    AC A0A0Q4V3Y6.1
#=GS A0A1I8AWC7_9BILA/90-249     AC A0A1I8AWC7.1
#=GS A0A218ZTS1_9EURY/81-277     AC A0A218ZTS1.1
#=GS A0A1U7PSH5_9FLAO/159-414    AC A0A1U7PSH5.1
#=GS A0A1I0I2V6_9ALTE/145-348    AC A0A1I0I2V6.1
#=GS A0A1J0P918_9SYNE/55-282     AC A0A1J0P918.1
#=GS W1S723_9SPHN/64-266         AC W1S723.1
#=GS A0A1R4GCV8_9MICO/146-334    AC A0A1R4GCV8.1
#=GS I2EX30_EMTOG/54-167         AC I2EX30.1
#=GS A0A254R8B2_9RHOB/220-421    AC A0A254R8B2.1
#=GS A0A0F3KUY6_9NEIS/57-277     AC A0A0F3KUY6.1
#=GS V8CBW8_9HELI/215-447        AC V8CBW8.1
#=GS A0A0M2HNL1_9MICO/116-299    AC A0A0M2HNL1.1
#=GS A0A1Y2SRV8_9GAMM/70-268     AC A0A1Y2SRV8.1
#=GS Q8TKK7_METAC/64-265         AC Q8TKK7.1
#=GS A0A1H6VDM3_9FLAO/60-252     AC A0A1H6VDM3.1
#=GS A0A085BQ28_9FLAO/67-267     AC A0A085BQ28.1
#=GS A0A1C4Z2E1_MICVI/133-328    AC A0A1C4Z2E1.1
#=GS A0A1I5RTE9_9BURK/61-258     AC A0A1I5RTE9.1
#=GS A0A1V9DC70_9GAMM/141-342    AC A0A1V9DC70.1
#=GS X0KSR6_FUSOX/481-670        AC X0KSR6.1
#=GS M0H0P2_9EURY/170-371        AC M0H0P2.1
#=GS A0A077LBU4_9PSED/498-698    AC A0A077LBU4.1
#=GS N6X5G3_9ALTE/134-339        AC N6X5G3.1
#=GS A0A1U7EUN6_NATPD/162-363    AC A0A1U7EUN6.1
#=GS D4K5P5_9FIRM/145-348        AC D4K5P5.1
#=GS R2PYF6_9ENTE/110-311        AC R2PYF6.1
#=GS A0A1D8SM97_9ACTN/130-331    AC A0A1D8SM97.1
#=GS B4VN48_9CYAN/133-344        AC B4VN48.1
#=GS A0A059KRP8_9BURK/60-257     AC A0A059KRP8.1
#=GS A0A177N8I5_9GAMM/287-490    AC A0A177N8I5.1
#=GS A0A0S8B575_9PROT/63-265     AC A0A0S8B575.1
#=GS D2RV70_HALTV/149-350        AC D2RV70.1
#=GS A0A1Y4HD63_9ACTN/786-982    AC A0A1Y4HD63.1
#=GS A0A2G3J4L6_9NEIS/108-310    AC A0A2G3J4L6.1
#=GS A0A0Q9YZR0_9COXI/58-163     AC A0A0Q9YZR0.1
#=GS A0A1Z4R3G7_9CYAN/380-581    AC A0A1Z4R3G7.1
#=GS V5B3P8_TRYCR/25-147         AC V5B3P8.1
#=GS S8DDJ4_9LAMI/401-608        AC S8DDJ4.1
#=GS A0A0D3B1Z0_BRAOL/516-723    AC A0A0D3B1Z0.1
#=GS A0A2G9HKQ2_9LAMI/613-820    AC A0A2G9HKQ2.1
#=GS A0A1M6XJ10_9BURK/107-307    AC A0A1M6XJ10.1
#=GS A0A165IUQ1_9BURK/204-405    AC A0A165IUQ1.1
#=GS J4XNK6_9FIRM/133-338        AC J4XNK6.1
#=GS A0A241R558_9GAMM/73-275     AC A0A241R558.1
#=GS E7A921_HELFC/266-499        AC E7A921.1
#=GS A0A1Z4JXD0_9CYAN/73-271     AC A0A1Z4JXD0.1
#=GS A0A239HT87_9BACT/69-272     AC A0A239HT87.1
#=GS A0A0M4FT92_9BACI/76-274     AC A0A0M4FT92.1
#=GS A0A0L6CTW0_9RHOB/333-533    AC A0A0L6CTW0.1
#=GS A0A1B3LRN0_9PROT/140-345    AC A0A1B3LRN0.1
#=GS A0A1C6R189_9BURK/593-793    AC A0A1C6R189.1
#=GS A0A1E8E169_9GAMM/67-270     AC A0A1E8E169.1
#=GS A0A238VJV8_9BACT/140-341    AC A0A238VJV8.1
#=GS L1M632_PSEPU/103-303        AC L1M632.1
#=GS A0A0V7ZNH7_9CYAN/145-356    AC A0A0V7ZNH7.1
#=GS C4LJH9_CORK4/73-293         AC C4LJH9.1
#=GS A0A1Z9JAR5_9CYAN/101-305    AC A0A1Z9JAR5.1
#=GS R0HW52_9BRAS/553-760        AC R0HW52.1
#=GS A0A1T4Q0Q9_9SPIO/83-284     AC A0A1T4Q0Q9.1
#=GS A0A2A2FHY7_9EURY/150-258    AC A0A2A2FHY7.1
#=GS K7KI96_SOYBN/538-745        AC K7KI96.1
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