#=GF ID   Med3
#=GF AC   PF11593.11
#=GF DE   Mediator complex subunit 3 fungal
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF SE   manual
#=GF GA   29.30 29.30;
#=GF TC   29.90 29.40;
#=GF NC   29.20 29.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF WK   Mediator_(coactivator)
#=GF RN   [1]
#=GF RM   15175151
#=GF RT   A unified nomenclature for protein subunits of mediator
#=GF RT   complexes linking transcriptional regulators to RNA polymerase
#=GF RT   II. 
#=GF RA   Bourbon HM, Aguilera A, Ansari AZ, Asturias FJ, Berk AJ,
#=GF RA   Bjorklund S, Blackwell TK, Borggrefe T, Carey M, Carlson M,
#=GF RA   Conaway JW, Conaway RC, Emmons SW, Fondell JD, Freedman LP,
#=GF RA   Fukasawa T, Gustafsson CM, Han M, He X, Herman PK, Hinnebusch
#=GF RA   AG, Holmberg S, 
#=GF RL   Mol Cell. 2004;14:553-557.
#=GF RN   [2]
#=GF RM   10722672
#=GF RT   Hrs1/Med3 is a Cyc8-Tup1 corepressor target in the RNA
#=GF RT   polymerase II holoenzyme. 
#=GF RA   Papamichos-Chronakis M, Conlan RS, Gounalaki N, Copf T,
#=GF RA   Tzamarias D; 
#=GF RL   J Biol Chem. 2000;275:8397-8403.
#=GF DR   INTERPRO; IPR020998;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   Mediator is a large complex of up to 33 proteins that is
#=GF CC   conserved from plants to fungi to humans - the number and
#=GF CC   representation of individual subunits varying with species. It
#=GF CC   is arranged into four different sections, a core, a head, a tail
#=GF CC   and a kinase-activity part, and the number of subunits within
#=GF CC   each of these is what varies with species. Overall, Mediator
#=GF CC   regulates the transcriptional activity of RNA polymerase II but
#=GF CC   it would appear that each of the four different sections has a
#=GF CC   slightly different function [1]. Mediator subunit Hrs1/Med3 is a
#=GF CC   physical target for Cyc8-Tup1, a yeast transcriptional
#=GF CC   co-repressor [2].
#=GF SQ   34
#=GS A0A1G4JS46_9SACH/14-346   AC A0A1G4JS46.1
#=GS A0A1X7R5Q2_9SACH/18-394   AC A0A1X7R5Q2.1
#=GS G0WA71_NAUDC/11-385       AC G0WA71.1
#=GS C5E049_ZYGRC/9-145        AC C5E049.1
#=GS A0A7H9B463_ZYGMR/8-367    AC A0A7H9B463.1
#=GS C5DHV2_LACTC/14-351       AC C5DHV2.1
#=GS G8ZWS1_TORDC/6-173        AC G8ZWS1.1
#=GS A0A1G4JCG7_9SACH/2-384    AC A0A1G4JCG7.1
#=GS A0A0C7N4X0_9SACH/15-361   AC A0A0C7N4X0.1
#=GS J4WEV1_BEAB2/710-868      AC J4WEV1.1
#=GS MED3_CANGA/13-481         AC Q6FXZ4.1
#=GS B4UMX1_CANGA/13-477       AC B4UMX1.1
#=GS A0A1G4MBB3_LACFM/180-318  AC A0A1G4MBB3.1
#=GS G8ZWS1_TORDC/126-323      AC G8ZWS1.1
#=GS A0A1E4T677_9ASCO/38-263   AC A0A1E4T677.1
#=GS MED3_YEAST/3-397          AC P40356.2
#=GS I2GX35_TETBL/12-175       AC I2GX35.1
#=GS J6EII9_SACK1/3-412        AC J6EII9.1
#=GS H2AZT1_KAZAF/9-259        AC H2AZT1.1
#=GS G8BZH5_TETPH/11-383       AC G8BZH5.1
#=GS A0A0A2VVG2_BEABA/145-309  AC A0A0A2VVG2.1
#=GS A0A507AUA6_9PEZI/371-642  AC A0A507AUA6.1
#=GS A0A1G4MBB3_LACFM/8-168    AC A0A1G4MBB3.1
#=GS A0A1S7HET9_9SACH/8-328    AC A0A1S7HET9.1
#=GS G8JM86_ERECY/6-202        AC G8JM86.1
#=GS J7S5W6_KAZNA/5-148        AC J7S5W6.1
#=GS J8LNQ4_SACAR/3-398        AC J8LNQ4.1
#=GS MED3_KLULA/8-230          AC Q6CNQ9.1
#=GS A0A1S7HVQ3_9SACH/8-324    AC A0A1S7HVQ3.1
#=GS A0A7H9HR83_9SACH/6-314    AC A0A7H9HR83.1
#=GS A0A1E5RAI1_9ASCO/24-471   AC A0A1E5RAI1.1
#=GS MED3_ASHGO/7-197          AC Q752T7.2
#=GS A7TKX4_VANPO/10-372       AC A7TKX4.1
#=GS A0A2N6NMW4_BEABA/656-812  AC A0A2N6NMW4.1
A0A1G4JS46_9SACH/14-346              ..........................rple----------NLFERLGSDHE..........--FKNSIKQELQNVQNSILPMRLHFNELLNAMASIDA--.....KQESSALERFTYVRTKLLEFMKDVDTLSSDYVRLQPLFDGLQQASK-DDNISVKFSPLERL..........................SNIN.D.AA..LA---T..A.GR..PQ....SGK.RSNVNSPSAL..--AAA..STTK..S..AVSSGN-----................................---TPS.--SNLPTP...STT.A-.--SAAAKKPR.KP..RTKKNs...............gpSPSSMPS.QPQ...PPSQALQQAI..............................HQ....QQP....AQS--.MQHQK.........QFTPS-T.....NPSQ-LLSGM.SPMNIMSS.PL-N.........TMSPVN.---..-GSN.MSFPP.....G..G.KPS.NMHSVQ....-----.................------.RHVQPSQPS............................FNSNSITPANILSMSM--S-...-----DQSNP..A---A.......AYT---...----......-QMN...PQ.G.SVNQD.LGSLDLNNIDLSNLNMDFL....................................
A0A1X7R5Q2_9SACH/18-394              ..............................SILTLHMKLEELERRLAQNPQ..........--GKEQLALTLSTTRESILPIRLELNNFIHMVSNIAD-D.....KNGITNQEKFHNVRTMLLKLHTSIQSLSQRFQELSPLFGTVPEYTTEYKSKE--YQPLETLtptnipq............tpavndpSNKA.T.SG..NTATSN..T.TA..TN....TNN.ITSTGAPATT..TTTTA..TKKGrgS..AASLKSPPTA-................................-ANTPT.--TGTATP...ATT.STnASTTTAKKPR.KP..RQKKS..................VSSAKNT.PAA...THATTTNTNS..............................VV....ATP....LSATT.MNPTL.........----SVP.....--P-QLMTGM.IPGNIVGM.SPTN.........TMMNMA.---..-PQM.QPQMQ.....F..N.SNN.MNNRQT....-----.................----GN.TPGPQGQLS............................PQNNTITPANILSMG-----...SNNNITNNSN..LVSN-.......----NS...NNNN......NNNN...NQ.GpNAMND.FGNLDLNNIDLSSLNMDFL....................................
G0WA71_NAUDC/11-385                  ..............................KLLTPKLTLDQLEDRLAGDIDnldttdlsddSLPKQVIANSLIETEKSILPLRLVFNKLIQTMATLDT--.....MPEKSQQEMFLSIRNQLLDLYTKIQEISTDFQHLQPLFGTIEEYSE--KNNTKKFHMLETLkpiv.................epapaTAKA.T.KG..DASHSK..K.KS..VA....GTP.GSVGNTPVGT..-TPGS..STGT..V..AANVPA-----................................NINANT.TNTSTTSA...AST.TQ.TTSSTAKKPR.KP..RQNKK..................--AAAKA.QQQ...QQQQLLQQQQ..............................QQ....QIPkqqgIATNP.MMNMN.........AM-----.....NATP-MMNSV.SPSNVMGT.PLNN.........GISPMG.AVM..AGGF.YSQPP.....G..S.QSQ.QFDQQM....NNGDH.................---NTN.NNNF-----............................QNMNNITPANILSMNTVGDP...------QSRM..ASSSQ.......QYP---...----......--TN...NN.N.NN---.--TLDLNNLDLSSLNMDFL....................................
C5E049_ZYGRC/9-145                   .............................e-ILSINMKLDELESKLSSGDS..........--SKESVMGAINETKGSILPMRLKFNDFLQTMSSIDK--.....MQEVSPDEKFLLIKSKLLELTNSMQQVSEEFTKLQPLFDTVPEYAERYGNKR--YLPLETL.........................rSATN.G.NG..ND-FS-..-.--..--....---.----------..-----..----..-..-----------................................------.--------...---.--.----------.--..-----..................-------.---...----------..............................--....---....-----.-----.........-------.....----------.--------.----.........------.---..----.-----.....-..-.---.------....-----.................------.---------............................--------------------...----------..-----.......------...----......----...--.-.-----.-------------------aqqlnqpnqq..........................
A0A7H9B463_ZYGMR/8-367               .............................e-MLTPNIKLEELESKLVA-SD..........GDCRDKVMGSIDNTQKAILPMRLLFNDFIQSMSNVDN--.....LGGENPKENFLLIRSKVLELSTRVQVVADDFNKLQPLFETISEYST--KHGDKKYQPLETL..........................KSFS.P.NG..GAITNN..V.LS..GA....NVN.GIAANINSTS..--VES..STKK..Y..NRSNNG----T................................PINAST.PGSSTPTS...AVP.P-.-----AKKPR.KP..RQSKK..................AIA-ANS.K--...--------NQ..............................TH....PSA....ISGTP.--AAN.........GM-GSTP.....NASM-PVISV.PPTNMMASpPLSA.........MMSPMA.PAN..FAAT.PQSQA.....Q..S.QPQ.QQPQQQ....PQSQAqlqaqtqsqvqvppvpqS-----.--------QqalsqaqqqrqqrqfspplrnnaasqshLNMNNITPANILNMSMTREG...QHVSMQPQQA..QQPPQ.......------...----......----...--.-.-----.-------------------pq..................................
C5DHV2_LACTC/14-351                  .......................kefdfgn-----------LHEKLESED-..........-GYKDSVKQEIQSVQDSIQPMRLRFNELLNMLAIIDQ--.....ETEVSNQEKFLSIRAKIVEFVSELQAFSSSYGRLQPLFDNIQQQPKGGKTSI-KFTPLERLr........................hLSDA.S.LG..NQAK-S..A.SG..GS....PPA.AAVASVPTTT..KQPKS..STNT..P..TSNAATPSATF................................NA----.--------...---.--.----AAKKSR.KS..RSKKNslptg.......lgghpvATAASPA.AVA...AAAAAVSTN-..............................-P....GVA....MGSNP.GIQQQ.........-F---TPs...tNPTQ-ILSSM.SPMNMMSS.P-MN.........IMSPAN.--N..VNMA.YTGPT.....K..-.---.------....-----.................PP-VPS.HRHMPSSSQ...........................qMNMNGITPANILNMS-----...MMEQANQPHL..TTA--.......--PAPQ...PPNQ......LDMN...--.-.-N---.---LDLNNLDLSNLNMDFL....................................
G8ZWS1_TORDC/6-173                   ..............................DLLVPDMKLEELETSLATGGD..........-DPKDRVDKAITDAQNSILPMRLQFNDFMHTMSNIDD--.....LQNSTPMEKFNLIRSKVLDLSDKLQTMSEDVGKLHPLFDTIPEYSE--KYGTKKFQPLETLripqsn..............svsspqTQNN.AiVG..ANLNKK..AnRS..ND....GTP.VSQTSTPMGS..AVP--..----..-..-----------................................------.--------...---.--.----------.--..-----..................-------.---...----------..............................--....---....-----.-----.........-------.....----------.--------.----.........------.---..----.-----.....-..-.---.------....-----.................------.---------............................--------------------...----------..-----.......------...----......----...--.-.-----.-------------------tpya................................
A0A1G4JCG7_9SACH/2-384               ...........................tdn-------SVKEMETRFAQEDG..........-LQTE-LVREFQAPKGLIMPLRLQFNDLLNTMATIDQ--.....NKGKSAHENFQMVRAKVIALNSQIQEFSRQVKGLEPRFESLEKYAT--EMKTSKFAPLETL..........................SRSS.E.-A..AAVQ-Q..S.KN..VS....GI-.SGLSGGPSVA..SGP--..SPAS..A..AARASY----S................................SANTPN.SSVSTPSG...AQ-.--.--GAAARKPK.RS..RAKKNsvsgsmpgsmpsgmssgmPGSVPGT.QPL...QQMSLAPQQP..............................QQqqhhQMP....MPS--.-----.........------A.....NPGQ-ILANM.SPANMMSS.P-MN.........VISPMN.TGL..SGVM.GSSF-.....-..-.SSN.SMMTSA....NKPQT.................--APQQ.RQAVPTPQQ............................INMSNITPANILTMSMMDKN...MNNPAIRSQP..QQQPA.......QQPQPQ...QQQQptpqprTQTQ...QLpQ.VGSND.FTNLDLNNLDLSNLNMDF-f...................................
A0A0C7N4X0_9SACH/15-361              ...............dskshsvdkvferlg-----------------SD--..........DSYKDSVKQELQHVQDSILPMRLKFNELLSTLAAIDR--.....KGESSSAETFNQIRTKLLEFISGVQQFSSDYGKLQPLFERLQEVSKSEDTIV-NFVPLERL..........................SRLN.D.AS..TT-ASG..G.KI..SN....GNS.PSANFVSTGK..QAP-S..NAQT..P..LSNVPT-----................................----PS.--------...-SV.D-.--NAPAKKPR.KP..RAKKT..................AGPSPSSiAPQ...QQQQQKQQPQ..............................QH....QQP....QPPQ-.----Q.........HFTP-AT.....NPSQ-ILQSM.SPMNMMSS.P-MN.........TISPMNnAAP..ISQIpFSAPS.....K..P.P--.--MQQQ....QRH--.................------.VQQTP-QQQ............................FNLDSITPANILHMS-MSDH...GNTPHAQQTNsqQQQQQ.......QQPQPQ...QQ--......QQHL...QS.S.NQ--D.FSALDINNIDLSSLNMDFL....................................
J4WEV1_BEAB2/710-868                 .............endqsfrrkrrtdgkvk---------------------..........---------------------------------------.....-------------------------------------------------------------..........................----.-.--..------..-.--..--....---.----------..----A..NTKN..L.dTSEVPIPTTIE................................ELSPPVrTHRSSSWG...PVA.AT.SPSEEQRSPR.NG..NSNHD..................AQSQAQQ.QQQ...QQQHQHQQQQqy..........................qqQQ....QQQ....IAQNGdFDSFD.........SM-SSFP....gDPSAMVM---.--------.----.........------.---..----.-----.....-..-.---.------....-----.................------.---------............................--------------------...----------..-----.......------...----......----...--.-.-----.-------------------dppfpqpllpqdlfalpmtldwnwaemsggayp...
MED3_CANGA/13-481                    ..............................DVLTPSMSLTELEMKFADETD..........GKAKDVVQARIKKAEDGILPLRLQFNDFTQIMSSLDEER.....YANVSKQEKFQMIRSKVLGLTERLQELSNDFEELQPLFATVGEYSKTYKNKN--FQVLENL..........................ASYN.H.RG..KA---G..A.SI..SN....STP.TPAAATPTTA..PTPGA..GTKK..A..AKTAPTPTATA................................TIGTPS.--NNAPTP...ATT.AT.TPGTQAKKPR.KP..RQTKKqq.............qaaAAAAAVA.QAQ...AQAQAQAQNQnqnnmqnknisnpgmnsnmgtpvmgnpnmkQM....QSP....IPANA.MNNMNvp....hngAMRPSVPngnmgNPSMGNLNMN.APN--MGN.PNMNnpnmnnpnaMMSPMAgQGQ..LNQM.FPMQN.....H..N.QNG.QFMGQQ....SPGPNigq...........mqfPPNNGN.MNGMPGTSDmnlgmnp..............smnmnmgMNLNQITPANILSMNTKGKDdqmQNIGMDQNQN..QNQSQ.......NQSQNQ..nQSMN......MNMN...ND.S.NNPKSaYDLVDFNSLDLSSLNMDFL....................................
B4UMX1_CANGA/13-477                  ..............................DVLTPSMSLTELEMKFADETD..........GKAKDVVQARIKKAEDGILPLRLQFNDFTQIMSSLDEER.....YANVSKQEKFQMIRSKVLGLTERLQELSNDFEELQPLFATVGEYSKTYKNKN--FQVLENL..........................ASYN.H.RG..KA---G..A.SI..SN....STP.TPAAATPTTA..PTPGA..GTKK..A..AKTAPTPTATA................................TIGTPS.--NNAPTP...ATT.AT.TPGTQAKKPR.KP..RQTKKqq.............qaaAAAAAVA.QAQ...AQAQAQAQNQnqnnmqnknisnpgmnsnmgtpvmgnpnmkQM....QSP....IPANA.MNNMNvp....hngAMRPSVPngnmgNPSMGNLNMN.APN--MGN.PNMNnpnmnnpnaMMSPMAgQGQ..LNQM.FPMQN.....H..N.QNG.HFMGQQ....SPGPNigq...........mqfPPNNGN.MNGMPGTSDmnlgmnp..............smnmnmgMNMNQITPANILSMNTKGKDdqmQNIGMDQNQN..QNQNQ.......NQN---...QSMN......MNMN...ND.S.NNPKSaYDLVDFNSLDLSSLNMDFL....................................
A0A1G4MBB3_LACFM/180-318             .................nsipgaasiplqa---------------------..........---------------------------------------.....-------------------------------------------------------------..........................----.-.--..------..-.--..--....---.----------..-----..----..-..-----------................................------.--------...---.--.----------.--..-----..................-------.---...----------..............................--....---....-----.-----.........----SPP....tNPSQ-ILSNM.SPMNMMSS.PM-S.........TMSPVN.-GS..MNLP.Y----.....-..N.GSA.SI----....STAPK.................PQ-SQP.QRHIPSASQ...........................qLNMNNITPANILNMS-----...---MMEQNPM..QAPSS.......QQSQLS...QP--......---Q...HQ.S.SNSLD.LNSLDLNNIDLASLNMDFL....................................
G8ZWS1_TORDC/126-323                 .................snsvsspqtqnna---------------------..........---------------------------------------.....-------------------------------------------------------------..........................----.-.--..------..-.--..--....---.----------..-----..---I..V..GANLNKKANRS................................NDGTPV.SQTSTPMG...SAV.PT.PYATTAKKPR.KP..RQPKKpq..............tpA----AA.AAA...AAVAANGHIK..............................SQ....ASP....TPP--.----A.........HMVSSVPa...tNPVQ-MVNSV.PPTNMMGT.PMQN.........LMSPLG.-NT..PNYG.FSQQQ.....S..Q.QQP.T-PQQQ....-QRQQ.................YNSATK.NSTMPQSQP............................MNLNSITPANILSMSMTGDP...----LHQQQQ..QNK--.......------...----......----...--.-.-----.-------------------ke..................................
A0A1E4T677_9ASCO/38-263              ...................dletgkldias---------------------..........------VIVEVQELKSKISGLRYEMCQYIRLLSSIEETS.....----VPLLVFQEVSNQISVLKSQIDSYYTSYRRLLPVIRYTK--LKIGLNPDDQIKILVHDvkves................klildTSIK.S.DG.lNVGMSN..S.GS..GI....GSG.TNSVSTKFVA..STPQS..SVPP..A..S-SASS-----................................MITTPG.IANTPGSL...APArKN.TATKKVVKPR.AP..TKKQQa...............aaAAAAAA-.---...AQKQATQQQG..............................KQ....Q--....-----.-----.........-------.....----------.--------.----.........------.---..----.-----.....-..-.---.------....-----.................------.---------............................--------------------...----------..-----.......------...----......----...--.-.-----.-------------------pqkngqgsltq.........................
MED3_YEAST/3-397                     ..............................SIIPAGVKLDDLQVILAKNEN..........-ETRDKVCKQINEARDEILPLRLQFNEFIQIMANIDQEG.....SKQADRMAKYLHIRDKILQLNDRFQTLSSHLEALQPLFSTVPEYLKTADNRDRSFQLLEPL..........................STYN.K.NG..NAVCST..A.TV..VS....TNH.SAAASTPTTT..ATPHA..NPIT..H..AHSLSNPNSTAtmqhnpla...............gkrgpksgsTMGTPT.VHNSTAAA...PIA.A-.-----PKKPR.KP..RQTKK..................AKAQAQA.QAQ...AQAQVYAQQS..............................TV....QTP....ITA--.-----.........SMAAALP.....NPTPSMINSV.SPTNVMGT.PLTN.........MMSPMG.---..--NA.YSMGA.....Q..N.QGG.QVSMSQfngsGNGSN.................PNTNTN.SNNTPLQSQ............................LNLNNLTPANILNMS-----...MNNDFQQQQQ..QQQQQ.......QQPQPQ...YNMN......MGMN...NM.N.NGGKE.LDSLDLNNLELGGLNMDFL....................................
I2GX35_TETBL/12-175                  .............................a-LLPKDCNISKLESSLAANPA..........--SHEALQRQLSQMQQQVLPLRLLFNNLLSILSGTND--.....-TIADNEIYYSTVREMVVEISQQLQNISGNMAQLEPILSTVRSYNQ-EPNRSSFSQLLQNLs.......................etKSLS.Q.KF..PQPIMT..T.AS..SN....KRS.KSQAATPISS..-----..-TSN..-..-----------................................------.--------...---.--.----------.--..-----..................-------.---...----------..............................--....---....-----.-----.........-------.....----------.--------.----.........------.---..----.-----.....-..-.---.------....-----.................------.---------............................--------------------...----------..-----.......------...----......----...--.-.-----.-------------------qnvnlssvapap........................
J6EII9_SACK1/3-412                   ..............................SIIAADVKLEDLEVALAKNEN..........-ETRDNVCKEISEARDEILPLRLQFNEFIQTMASIDKDG.....PKQGSRMARYLQVRDKILQLNGRFQSLSSHLEALQPLFSTVPEYLKTADNKDRSFQLLEPL..........................STYN.Q.NG..TVAGPA..A.AV..VN....TSH.STAASTPTTT..-TPHA..NPIA..HahAHSLSQPNSMAtmqqhsla...............gkrghkgssSIGTPN.APNSTVAA...ATA.A-.-----TKKPR.KP..RQTKKaka............qaqAQAQAQA.QAQ...AQAQVYSQQS..............................AV....QTP....ITA--.-----.........SMAAALP.....NPTPNMINSV.SPTNVMGT.PLTN.........MMSPMA.---..--NG.YSWGG.....Q..T.QGGgQPGMPQfnnnGNGTN.................PNPSTN.SNNTPLQSQ............................LNLNNLTPANILNMS-----...MNTDFQQQQQ..PQQPQqpqqqlpQQPQQQ...YNMN......MGMN...TM.N.NNGKE.LDSLDLNNLELGGLNMDFL....................................
H2AZT1_KAZAF/9-259                   ..............................EVLTLTVKLEELETKFATNEN..........--SKQSVLDLVNETRSLILPIRLQLNEFISLMANIDK--.....MTETSNIDKYNHIRKSLLTLQNNIQTLSQNFVKLNPLFNTIPEYST--KHNSREFKPLESL..........................SNDPfA.KG..SP--RT..T.SS..GS....ANN.TITSATSITT..---NA..NNKI..S..AATPS-----S................................NINTPA.----SSSQ...NIT.NT.TPS--IKKPR.KP..RQPRK..................SITQTNT.ANK...AS---KTTTP..............................SA....PTP....VAA-P.MQTPG.........TMNPALP.....VQ---NFNTK.TPIN-LGS.PNGP.........QFS---.---..----.-----.....-..-.---.------....-----.................------.---------............................--------------------...----------..-----.......------...----......----...--.-.-----.-------------------pppq................................
G8BZH5_TETPH/11-383                  ........................ffntve-------SLENLEDKLVMNNF..........-ENKDILMEKISSTQKSILPIRLLFNEFIQTMALLNDGKghkteNNNEEALAKFYLVRDKLVRLSECLQNLSSDMSNLKPLFDLISEYSL--KNNSKQFDPLETLkqidndvfn........sqaalatnaADSQ.N.NG..KTKAKN..S.TS..TA....ATP.NSSVNTPITN..--LGS..QTIL..S..NTNASVPALATtptt.......................vtkgaSVASAS.-SKSVTAN...LSS.VN.VPAATTKKPR.KP..RQTKK..................STATSK-.KLQ...SNSAASPMNP..............................PT....PSN....ITANK.RANKA.........SAQTA--.....QSTGNMLGMNgSQQNVAGN.MNNN.........NNNNMV.--Q..RNNS.ISMNS.....Q..DfMAM.QYKNGN....GNGNA.................PMNNQM.MNNQMINNQ............................MINNQMLNQQQMKMNNMGNM...-NM-------..-----.......------...----......----...--.-.-----.-------------------gnmgnmg.............................
A0A0A2VVG2_BEABA/145-309             ..........ekaendqsfrrkrrtdgkvk---------------------..........---------------------------------------.....-------------------------------------------------------------..........................----.-.--..------..-.--..--....---.----------..----A..NTKN..L.dTSEVPIPTTIE................................ELSPPVrTHRSSSWG...PVA.AT.SPSEEQRSPR.NG..NPNHD..................AQSQAQQ.QQQ...QQQHQHQQQQqy..........................qqQQ....QQQ....IAQNGdFDSFD.........SM-SSFP....gDPSAMVM---.--------.----.........------.---..----.-----.....-..-.---.------....-----.................------.---------............................--------------------...----------..-----.......------...----......----...--.-.-----.-------------------dppfpqpllpqdlfalpmtldwnwaemsggaypsve
A0A507AUA6_9PEZI/371-642             .....................vliddlkad---------------------..........---------------------------------------.....----------------------------------DDVVKKIEEYQK-EKEEARKAEQEKPK..........................SPVA.D.KA..SPVAET..D.TK..SN....GQQ.EKRESAKSSK..-SPTP..PPAS..A..AASAKSPSAEP................................S-AKPA.ANNATGTP...AAT.DG.DSQSSKKRPAeEP..AENPK..................VPKAPKA.MQQ...QQQEA-QQQQ..............................MM....QHM....MNS-M.MPGMNgmggmpgmpGM-PMMP.....FGGMPMMNNF.PP---MGM.PNMNmn.....mgMMNPM-.---..MNPM.MGMPNfgnngM..N.GGG.GFGPGN....NNGMGggwg........msgggPPMNGGpMNGG-YNQQ............................FNNNN---------------...----------..-----.......------...----......----...--.-.-----.-------------------ggggnkmmggnfgqq.....................
A0A1G4MBB3_LACFM/8-168               ...........................qav-----RLKMEEMEDKLGSD--..........SMYKDSVLQDIRKAKDSILPMRLRFNDLINTIASIDK--.....TQGKSSQEKFTMIRAKVLELSTEIQSFCGEYHKLQPVFEAMQQYSKEGK-TSKKFTPLETL..........................RHVN.E.V-..------..-.TI..NT....QSK.PPNATSPSNA..RLNKS..NVNT..P..ASNVPTPSAG-................................------.--------...---.--.----------.--..-----..................-------.---...----------..............................--....---....-----.-----.........-------.....----------.--------.----.........------.---..----.-----.....-..-.---.------....-----.................------.---------............................--------------------...----------..-----.......------...----......----...--.-.-----.-------------------gnva................................
A0A1S7HET9_9SACH/8-328               ..............................DILSINMKLDELELKLASTNG..........--VKESVIGTITEAQKSILPIRLKFNDFLQTMSSIDK--.....VDSVTPEEKFKMIRSKLLELTSSMQNVSEEFTKLQPLFDTVPEYAERYGNKR--YIPLETL..........................KSST.N.LG..NGLASQ..T.QL..QQ....QQQqQSQAQAQVQSqqQSQSQ..QPQS..Q..PQQLPNGNPVSssnsia...................srkpsksNAGTPG.SNMNTPSG...TTM.TN.-MTPSSKKQR.KP..RQPKKts.............sgiG--MGPA.STP...VMSASNFKAQ..............................TA....QSP...qVGT--.-----.........KIA-GAP....lNNTTQTVSSV.PPTSTMNT.PMNN.........VMSPLG.GVApgFGIS.QSQPP.....Q..S.MPQ.QISQQF....S----.................------.---------............................--------------------...----------..-----.......------...----......----...--.-.-----.-------------------qqlsqqrqqq..........................
G8JM86_ERECY/6-202                   ..............................EILSAKLTLEELKEKLANNDE..........--SKSAISGQIQLVKHNVLPLRLSFNDFLKTMSQIEH--.....LNDKSPQEKFLLIRAKVLELYGKLKELVRDFQKLMPLLDTMAVFSE--SNE-QKFYPLETLn........................lLPDP.I.KS..TASPSY..K.KA..VNksnaETP.SSNAATPSAA..-----..-LSS..N..NVVLVGPQAKNqrr.........................prtnNKRQPS.---GTASA...APS.A-.----------.--..-----..................-------.---...----------..............................--....---....-----.-----.........-------.....----------.--------.----.........------.---..----.-----.....-..-.---.------....-----.................------.---------............................--------------------...----------..-----.......------...----......----...--.-.-----.-------------------gsagsapis...........................
J7S5W6_KAZNA/5-148                   .............................e-LVPNGTKLADLEKRMVEDTM..........--VRDGLVVGLRQVREEILPIRLKFNAFLNKMSHLDSEP.....QGAKTNEERFKEVRDNLLDLYKSIQTLSARFHEIQPLFSVIEQFGAV--DGEKQFCPLETLgng....................ptvS---.-.--..------..-.--..--....---.----------..-----..----..-..-----------................................------.--------...---.--.----------.--..-----..................-------.---...----------..............................--....---....-----.-----.........-------.....----------.--------.----.........------.---..----.-----.....-..-.---.------....-----.................------.---------............................--------------------...----------..-----.......------...----......----...--.-.-----.-------------------sipttvptapvgkksavstp................
J8LNQ4_SACAR/3-398                   ..............................SIIPADTKLEDLEVKLAKNEN..........-ETRDNVCKQINEARNEILPLRLQFNEFIQSMANIDHDG.....TKQGDRMVKYLHIRDSILQLNDRFQSLSSHLETLQPLFNTVPEYLRTADNKDRSFQLLEPL..........................STYN.Q.NG..TVTGPA..A.AV..AN....TSH.STAASTPTTT..--PHA..NSNA..H..THSLSNPNTTTammqqnpma..............gkrgpkgstTIGTPN.---SAAAA...ATA.A-.-----AKKPR.KP..RQTKK..................AKAQAQA.QAQ...AQAQAQAQAQaqvy......................ahpsAV....QTP....ITA--.-----.........SMTAALP.....NPTPNIINSV.SPTNVMGT.PLTN.........MMSPMT.---..--NA.YSMVA.....P..N.QGG.QPAMSQftnhSNGTN.................PNPTTN.ANNTPLQSQ............................LNLNNLTPANILNMS-----...MNNDFQQQQQ..QQQQP.......QQPQQQ...Q---......YNMN...TM.N.NNGKE.LDSLDLNNLELGGLNMDFL....................................
MED3_KLULA/8-230                     .................qifkdnltfdtfr-------------ELIIEKE-..........-STADEVADKVLEAKKALLPIRTLMTEFVGMIANLES--.....MGNKTSQEKFLAIRMKLIELQNNIQKFSKDFQQLQPVMRTMDKFNEEVNAGEKKFFVQETLg........................yTQLA.S.NG..SAAGIT..K.TS..SG....NDG.NTTGSTANTM..-AMAK..GLKK..N..AAGKPN-TGTGvqsgpgrrn..............stkktghtgPATAPT.TSNSAASA...AAA.AA.NTPSL-----.--..-----..................-------.---...----------..............................--....---....-----.-----.........-------.....----------.--------.----.........------.---..----.-----.....-..-.---.------....-----.................------.---------............................--------------------...----------..-----.......------...----......----...--.-.-----.-------------------kqipntqpmqlm........................
A0A1S7HVQ3_9SACH/8-324               ..............................DILSTNIKLDELELKLASTGG..........--VKESVIGTITEAQKSILPIRLKFNDFLQTMSSIDK--.....VDSVTPEEKFKMIRSKLLELTNSMQDVSEEFTKLQPLFDTVPEYAERYGNKR--YIPLETL..........................KSST.N.LG..NGLPSQ..T.QL..QQ....QQS.QAQAQVQSQQ..QSQLQ..QPQS..Q..PQQLPNGNPASssnsia...................srkpnksNAGTPG.SNMNTPSG...TTM.TN.-MTPSSKKQR.KP..RQPKKt...............ssGIGMGSA.STP...VMSASSFKAQ..............................TA....QSP....QVG--.-----.........AKIAGAP....lNNTTQTVSSV.PPTSTMNT.PMNN.........VMSPLG.GVApgFGIS.QSQPP.....Q..S.IPQ.QISQQF....S----.................------.---------............................--------------------...----------..-----.......------...----......----...--.-.-----.-------------------qqlsqqrqq...........................
A0A7H9HR83_9SACH/6-314               ..............................DLLTPDLKLDDLEASLAGGTK..........-EPQEKVMNAIDKAQGSILPMRLQFNDFLQTMSSLDD--.....LQDQTPLEKFTMIRNKVLDLTNRLQMISEDVGKLQPLFDTIPEYSERYG--TKKFQPLETL..........................KLTS.Q.NS..------..-.--..--....---.--TISTPQTQ..NSGGS..NPLT..S..RK-ISK----S................................SGGTPV.SHTSTPLG...STA.PS.TFPAAGKKPR.KP..RQSKK..................AQATAVA.---...-ADTVKSQPS..............................TV....LSP....TPPAH.MIN--.........SA---PP....aNP-MQMMNGV.VPNTMMGS.PMQS.........LMSPVG.--N..TPNG.YGIPQ....qQ..M.QSQ.QPPQQF....-----.................-NQPAV.GNSVPPVQP............................LNMNSITPANILNMSMGADP...QQQPIQ----..-----.......------...----......----...--.-.-----.-------------------rkn.................................
A0A1E5RAI1_9ASCO/24-471              adlqslqkylleqvpqsepnnksasasial---------------------..........-------NGYMAKVQNEILPLRLEFNALLKQMAHLDN--.....-PQESGKQKYLALKARLVTVTTKINDLSQEFKKLQPLLYILKNNQKILETPN-SYYILETLdqlpqpeikvplpkqfqpkiintlpnAVSN.S.TGvnTAVSSA..Q.KAtkSP....VNS.VNSPSTPATA..KTPGSvaASNT..V..KHSLQGNLASA................................STFSG-.IRKNAKGS...GAN.AH.ASSGSVKKPA.TNskRGTPQ..................AFSPLSA.NTP...VTNVSASNNStnlsnigavy.........nsggrsknhdqVT....SAP...lSKANS.ANESP.........SMYMNTS.....NITPANILQN.LNS-SMGN.N--S.........QSSNMG.ALS..SRVG.M----.....N..G.PSG.NIGQQR....VN--N.................PNSNSN.SNNINNNSMn.........................ygNNMNNRVPSTDNSMGGYGYN...GNFSMSPSSI..LQNMN.......NLPNNNssvASGN......MSPNgslNT.N.NN--S.AGMLDLNTLDLSNLD-DFL....................................
MED3_ASHGO/7-197                     .............................g-ILRENLTLEELQEWLTSSEG..........--NKLAIDDHIKATQGRVLPLRLLFNEFLRTISHIEQ--.....LSDKTPQEKFQLIRSKLQELYGKLHALVRDFQRLQPLFDTMVPFSET---SERKFYPKETL..........................GTAV.E.PV..RPLASP..S.YR..RP....SNR.SSADTPSSNA..PTPSA..AVVS..G..AALVA------................................------.--------...---.--.----------.--..-----..................-------.---...----------..............................--....---....-----.-----.........-------.....----------.--------.----.........------.---..----.-----.....-..-.---.------....-----.................------.---------............................--------------------...----------..-----.......------...----......----...--.-.-----.-------------------pqvkhqrrprtntakrqpsvsasvvpsanss.....
A7TKX4_VANPO/10-372                  .............................t-ILSGKVKLEQLEDTLGLDDN..........--SRNTVVTAISQAHDSILPLRLQFNDLIRLLSHIEE--.....QPTQTSEEKYLLIRSKLLDLYKNIENLSIDVKQLQPLFQTVSEYSTKYKNKK--YQPLETLyqss..................tgatT--T.I.TS..SANTSNgpS.VT..GS....TSA.GSAANTPNVS..ASAST..TTKR..A..KSNAATPSSATntpnasgasvgtpnsasagitsgsgitpipttGVSAAS.GSAATTAAsisATT.PT.TTTTTVKKPR.KP..RQPKK..................TAAANKK.QPVpspLNSQIPLNTA..............................SI....NNN....NTSSA.YNNMKann...tnmKMA---PnagpmNNQAQMMGNP.SPKNMVNT.PLNN.........MMGSLG.--G..VSQD.YGMQL.....QtpN.QPT.PLQMQM....--GQ-.................------.---------............................--------------------...----------..-----.......------...----......----...--.-.-----.-------------------qgiqqqappsq.........................
A0A2N6NMW4_BEABA/656-812             .............endqsfrrkrrtdgkvk---------------------..........---------------------------------------.....-------------------------------------------------------------..........................----.-.--..------..-.--..--....---.----------..----A..NTKN..L.dTSEVPIPTTIE................................ELSPPVrTHRSSSWG...PVA.AT.SPSEEQRSPR.NG..NPNND..................AQSQAQQ.QQQ...QQQQQQQQQQy...........................qqQQ....QQH....VAQNGdFDSFD.........GM-SSFP....gDPSAMV----.--------.----.........------.---..----.-----.....-..-.---.------....-----.................------.---------............................--------------------...----------..-----.......------...----......----...--.-.-----.-------------------mdppfpqpllpqdlftlpmtldwnwaemsggay...
#=GC seq_cons                        .....................................plppLc.phstpt.............s+ptlhtplppspppILPhRLpFN-hlphhusl-p........tp.os.-+F.hlRs+llpL.splQplSpchppLpPLFpsl.pasc..pstp.patsLEsL..........................ss.s.p.tu..ss...t..s.t...ss....ss..tsssssssss.....tu..ssts.....stshst.....................................thssPs....sss.s...sss.s........+KPR.ps..pt.+p..................s.s.s.t.t......ttt...pt.....................................tt......ss.................th....s.....sss...h.....s...hs..s..s...........ssh......................................................................................................................................................................................................................................................
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