#=GF ID Med3
#=GF AC PF11593.13
#=GF DE Mediator complex subunit 3 fungal
#=GF AU Coggill P;0000-0001-5731-1588
#=GF SE manual
#=GF GA 29.30 29.30;
#=GF TC 29.30 29.30;
#=GF NC 29.00 28.70;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -E 1000 -Z 81514348 HMM pfamseq
#=GF TP Family
#=GF WK Mediator_(coactivator)
#=GF RN [1]
#=GF RM 15175151
#=GF RT A unified nomenclature for protein subunits of mediator
#=GF RT complexes linking transcriptional regulators to RNA polymerase
#=GF RT II.
#=GF RA Bourbon HM, Aguilera A, Ansari AZ, Asturias FJ, Berk AJ,
#=GF RA Bjorklund S, Blackwell TK, Borggrefe T, Carey M, Carlson M,
#=GF RA Conaway JW, Conaway RC, Emmons SW, Fondell JD, Freedman LP,
#=GF RA Fukasawa T, Gustafsson CM, Han M, He X, Herman PK, Hinnebusch
#=GF RA AG, Holmberg S,
#=GF RL Mol Cell. 2004;14:553-557.
#=GF RN [2]
#=GF RM 10722672
#=GF RT Hrs1/Med3 is a Cyc8-Tup1 corepressor target in the RNA
#=GF RT polymerase II holoenzyme.
#=GF RA Papamichos-Chronakis M, Conlan RS, Gounalaki N, Copf T,
#=GF RA Tzamarias D;
#=GF RL J Biol Chem. 2000;275:8397-8403.
#=GF DR INTERPRO; IPR020998;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC Mediator is a large complex of up to 33 proteins that is
#=GF CC conserved from plants to fungi to humans - the number and
#=GF CC representation of individual subunits varying with species. It
#=GF CC is arranged into four different sections, a core, a head, a tail
#=GF CC and a kinase-activity part, and the number of subunits within
#=GF CC each of these is what varies with species. Overall, Mediator
#=GF CC regulates the transcriptional activity of RNA polymerase II but
#=GF CC it would appear that each of the four different sections has a
#=GF CC slightly different function [1]. Mediator subunit Hrs1/Med3 is a
#=GF CC physical target for Cyc8-Tup1, a yeast transcriptional
#=GF CC co-repressor [2].
#=GF SQ 35
#=GS A0A7H9HR83_9SACH/6-314 AC A0A7H9HR83.1
#=GS G8BZH5_TETPH/11-380 AC G8BZH5.1
#=GS J7S5W6_KAZNA/5-127 AC J7S5W6.1
#=GS MED3_YEAST/3-397 AC P40356.2
#=GS MED3_YEAST/3-397 DR PDB; 7UIL c; 3-110;
#=GS MED3_YEAST/3-397 DR PDB; 7UIL 2; 3-110;
#=GS MED3_YEAST/3-397 DR PDB; 7UIK c; 3-110;
#=GS MED3_YEAST/3-397 DR PDB; 7UIC c; 3-110;
#=GS A7TKX4_VANPO/10-364 AC A7TKX4.1
#=GS W0T618_KLUMD/19-263 AC W0T618.1
#=GS A0A1E4T677_9ASCO/40-264 AC A0A1E4T677.1
#=GS A0A4C2EAK8_9SACH/9-128 AC A0A4C2EAK8.1
#=GS G0WA71_NAUDC/11-385 AC G0WA71.1
#=GS A0A1G4MBB3_LACFM/183-318 AC A0A1G4MBB3.1
#=GS A0A7H9B463_ZYGMR/8-279 AC A0A7H9B463.1
#=GS MED3_CANGA/13-481 AC Q6FXZ4.1
#=GS MED3_EREGS/7-199 AC Q752T7.2
#=GS A0A1G4JCG7_9SACH/2-384 AC A0A1G4JCG7.1
#=GS B4UMX1_CANGA/13-477 AC B4UMX1.1
#=GS J4WEV1_BEAB2/710-868 AC J4WEV1.1
#=GS I2GX35_TETBL/12-175 AC I2GX35.1
#=GS A0A1G4MBB3_LACFM/8-167 AC A0A1G4MBB3.1
#=GS J8LNQ4_SACAR/3-398 AC J8LNQ4.1
#=GS J6EII9_SACK1/3-412 AC J6EII9.1
#=GS C5DHV2_LACTC/14-351 AC C5DHV2.1
#=GS C5E049_ZYGRC/9-147 AC C5E049.1
#=GS G8ZWS1_TORDE/124-323 AC G8ZWS1.1
#=GS G8ZWS1_TORDE/6-173 AC G8ZWS1.1
#=GS G8JM86_ERECY/6-201 AC G8JM86.1
#=GS A0A0C7N4X0_9SACH/16-361 AC A0A0C7N4X0.1
#=GS A0A507AUA6_9PEZI/371-642 AC A0A507AUA6.1
#=GS A0A1X7R5Q2_9SACH/18-394 AC A0A1X7R5Q2.1
#=GS A0A0D2MAU2_9CHLO/466-686 AC A0A0D2MAU2.1
#=GS H2AZT1_KAZAF/9-257 AC H2AZT1.1
#=GS A0A1E5RAI1_9ASCO/25-471 AC A0A1E5RAI1.1
#=GS A0A1G4JS46_9SACH/11-346 AC A0A1G4JS46.1
#=GS A0A2N6NMW4_BEABA/656-813 AC A0A2N6NMW4.1
#=GS MED3_KLULA/8-229 AC Q6CNQ9.1
#=GS A0A0A2VVG2_BEABA/145-309 AC A0A0A2VVG2.1
A0A7H9HR83_9SACH/6-314 .............................DLLTPDLKLDDLEASLAGGTK..........-EPQEKVMNAIDKAQGSILPMRLQFNDFLQTMSSLDD--.....LQDQTPLEKFTMIRNKVLDLTNRLQMISEDVGKLQPLFDTIPEYSERY--GTKKFQPLETL..........................KLTS...Q.NS..------..-.--..--....-----TISTPQTQN.SGGS..NPLT..S..R...K-ISK----S................................SGGTPV.SHTSTPLG...STA.PSTFP...AAGKKPR.KP..RQSKK..................AQATAVA.---...-ADTVKSQPS..............................TVLSP....TPPAH.MIN--.........SA---PP....aNP-MQMMNGV.VPNTMMGS.PMQS.........LMSPVG.--NTP.NG.YGIPQqQ..M.QSQ.QPPQQF....-----.........-NQPAV.GNSVPPVQP..............LNMNSITPANILNMSMGADP...QQQPIQ----..-----.......------...----......----...--.-.-----.-------------------rkn..................................................
G8BZH5_TETPH/11-380 .......................ffntve-------SLENLEDKLVMNNF..........-ENKDILMEKISSTQKSILPIRLLFNEFIQTMALLNDGKghkteNNNEEALAKFYLVRDKLVRLSECLQNLSSDMSNLKPLFDLISEYSL--KNNSKQFDPLETLkqidndvfn........sqaalatnaADSQ...N.NG..KTKAKN..S.TS..TA....ATPNSSVNTPITN-.-LGS..QTIL..S..N...TNASVPALATtptt.......................vtkgaSVASAS.-SKSVTAN...LSS.VNVPA...ATTKKPR.KP..RQTKK..................STATSK-.KLQ...SNSAASPMNP..............................PTPSN....ITANK.RANKA.........SAQTA--.....QSTGNMLGMNgSQQNVAGN.MNNN.........NNNNMV.--QRN.NS.ISMNS.Q..DfMAM.QYKNGN....GNGNA.........PMNNQM.MNNQMINNQ..............MINNQMLNQQQMKMNNMGNM...-N--------..-----.......------...----......----...--.-.-----.-------------------mgnmg................................................
J7S5W6_KAZNA/5-127 ............................e-LVPNGTKLADLEKRMVEDTM..........--VRDGLVVGLRQVREEILPIRLKFNAFLNKMSHLDSEP.....QGAKTNEERFKEVRDNLLDLYKSIQTLSARFHEIQPLFSVIEQFGA--VDGEKQFCPLETL..........................G---...-.--..------..-.--..--....--------------.----..----..-..-...----------................................------.--------...---.-----...-------.--..-----..................-------.---...----------..............................-----....-----.-----.........-------.....----------.--------.----.........------.-----.--.-----.-..-.---.------....-----.........------.---------..............--------------------...----------..-----.......------...----......----...--.-.-----.-------------------ngptv................................................
MED3_YEAST/3-397 .............................SIIPAGVKLDDLQVILAKNEN..........-ETRDKVCKQINEARDEILPLRLQFNEFIQIMANIDQEG.....SKQADRMAKYLHIRDKILQLNDRFQTLSSHLEALQPLFSTVPEYLKTADNRDRSFQLLEPL..........................STYN...K.NG..NAVCST..A.TV..VS....TNHSAAASTPTTTA.TPHA..NPIT..H..A...HSLSNPNSTAtmqhnpla...............gkrgpksgsTMGTPT.VHNSTAAA...PIA.A----...--PKKPR.KP..RQTKK..................AKAQAQA.QAQ...AQAQVYAQQS..............................TVQTP....ITA--.-----.........SMAAALP.....NPTPSMINSV.SPTNVMGT.PLTN.........MMSPMG.-----.NA.YSMGA.Q..N.QGG.QVSMSQfngsGNGSN.........PNTNTN.SNNTPLQSQ..............LNLNNLTPANILNMS-----...MNNDFQQQQQ..QQQQQ.......QQPQPQ...YNMN......MGMN...NM.N.NGGKE.LDSLDLNNLELGGLNMDFL.....................................................
#=GR MED3_YEAST/3-397 SS .............................-SS-TT--HHHHHHHHTSGGG..........-HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTTSS-.....-SHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHSHHHHTHHHHHHHHH-XXXXXXXXXXXX..........................XXXX...X.XX..XXXXXX..X.XX..XX....XXXXXXXXXXXXXX.XXXX..XXXX..X..X...XXXXXXXXXXXXXXXXXX...............XXXXXXXXXXXXXXX.XXXXXXXX...XXX.X----...--XXXXX.XX..XXXXX..................XXXXXXX.XXX...XXXXXXXXXX..............................XXXXX....XXX--.-----.........XXXXXXX.....XXXXXXXXXX.XXXXXXXX.XXXX.........XXXXXX.-----.XX.XXXXX.X..X.XXX.XXXXXXXXXXXXXXX.........XXXXXX.XXXXXXXXX..............XXXXXXXXXXXXXXX-----...XXXXXXXXXX..XXXXX.......XXXXXX...XXXX......XXXX...XX.X.XXXXX.XXXXXXXXXXXXXXXXXXX.....................................................
A7TKX4_VANPO/10-364 ............................t-ILSGKVKLEQLEDTLGLDDN..........--SRNTVVTAISQAHDSILPLRLQFNDLIRLLSHIEE--.....QPTQTSEEKYLLIRSKLLDLYKNIENLSIDVKQLQPLFQTVSEYSTKYKNKK--YQPLETLyqss..................tgatTTIT...S.SA..NTSNGP..S.VT..GS....TSAGSAANTPNVSA.SAST..TTKR..A..K...SNAATPSSATntpnasgasvgtpnsasagitsgsgitpipttGVSAAS.GSAATTAAsisATT.PTTTT...TTVKKPR.KP..RQPKK..................TAAANKK.QPVpspLNSQIPLNTA..............................SINNN....NTSSA.YNNMKann...tnmKMA---PnagpmNNQAQMMGNP.SPKNMVNT.PLNN.........MMGSLG.G--VS.QD.YGMQL.QtpN.QPT.PLQMQM....G----.........------.---------..............--------------------...----------..-----.......------...----......----...--.-.-----.-------------------qqgi.................................................
W0T618_KLUMD/19-263 ............................e-ILKENLTFETFREKIIEK-D..........-SNGDEVKEKVLETKAELDPIRGLMLEFVTMLANLES--.....MSNKTSQEKFLAVRVKLIELQNKIQKFSKDFQQLQPLIQTMERFNEEIAG-EKKYFVQETL..........................GYAS...A.NP..TSSSAG..G.GT..SA....STSASAQSKTTKKAsGGRR..NSAK..K..G...NAVSA-SSTP................................NL--KQ.IPNNQPQQ...QQ-.--PQA...QIPQQPQ.IP..QQPQQ..................-----QP.QIP...Q---------..............................QMQIP....MQM--.--QMQ.........MMPGVSP.....MAMASPLNNI.SPQ-----.----.........------.-----.--.-----.-..-.---.------....-----.........------.---------..............--------------------...----------..-----.......------...----......----...--.-.-----.-------------------rklattmnq............................................
A0A1E4T677_9ASCO/40-264 ....................etgkldias---------------------..........------VIVEVQELKSKISGLRYEMCQYIRLLSSIEETS.....----VPLLVFQEVSNQISVLKSQIDSYYTSYRRLLPVIRYTK--LKIGLNPDDQIKILVHDvkves................klildTSIK...S.DG.lNVGMSN..S.GS..GI....GSGTNSVSTKFVAS.TPQS..SVPP..A..-...SSASS-----................................MITTPG.IANTPGSL...APArKNTAT...KKVVKPR.AP..TKKQQ..................-AAAAAA.AAA...AQKQATQQQG..............................KQQ--....-----.-----.........-------.....----------.--------.----.........------.-----.--.-----.-..-.---.------....-----.........------.---------..............--------------------...----------..-----.......------...----......----...--.-.-----.-------------------pqkngqgsltqp.........................................
A0A4C2EAK8_9SACH/9-128 ............................e-ILSLNMKLDELESKLSSEGS..........--SKESVMGAIDEAQGSILPMRLKFNDFLQTMSSIDK--.....MQEVGPDEKFLLIRSKLLELTSSMQQVSEEFTKLQPLFDTVPEYAERYGNKR--YLPLETL..........................RS--...-.--..------..-.--..--....--------------.----..----..-..-...----------................................------.--------...---.-----...-------.--..-----..................-------.---...----------..............................-----....-----.-----.........-------.....----------.--------.----.........------.-----.--.-----.-..-.---.------....-----.........------.---------..............--------------------...----------..-----.......------...----......----...--.-.-----.-------------------asn..................................................
G0WA71_NAUDC/11-385 .............................KLLTPKLTLDQLEDRLAGDIDnldttdlsddSLPKQVIANSLIETEKSILPLRLVFNKLIQTMATLDT--.....MPEKSQQEMFLSIRNQLLDLYTKIQEISTDFQHLQPLFGTIEEYSE--KNNTKKFHMLETLkpiv.................epapaTAKA...T.KG..DASHSK..K.KS..VA....GTPGSVGNTPVGT-.TPGS..STGT..V..A...ANVPA-----................................NINANT.TNTSTTSA...AST.TQTTS...STAKKPR.KP..RQNKK..................--AAAKA.QQQ...QQQQLLQQQQ..............................QQQIPkqqgIATNP.MMNMN.........AM-----.....NATP-MMNSV.SPSNVMGT.PLNN.........GISPMG.AVMAG.GF.YSQPP.G..S.QSQ.QFDQQM....NNGDH.........---NTN.NNNF-----..............QNMNNITPANILSMNTVGDP...------QSRM..ASSSQ.......QYP---...----......--TN...NN.N.NN---.--TLDLNNLDLSSLNMDFL.....................................................
A0A1G4MBB3_LACFM/183-318 ..................pgaasiplqas---------------------..........---------------------------------------.....-------------------------------------------------------------..........................----...-.--..------..-.--..--....--------------.----..----..-..-...----------................................------.--------...---.-----...-------.--..-----..................-------.---...----------..............................-----....-----.-----.........-----PP....tNPSQ-ILSNM.SPMNMMSS.PM-S.........TMSPVN.-GSMN.LP.Y----.-..N.GSA.SISTAP....KPQSQ.........-----P.QRHIPSASQ.............qLNMNNITPANILNMS-----...---MMEQNPM..QAPSS.......QQSQLS...QP--......---Q...HQ.S.SNSLD.LNSLDLNNIDLASLNMDFL.....................................................
A0A7H9B463_ZYGMR/8-279 ............................e-MLTPNIKLEELESKLVAS-D..........GDCRDKVMGSIDNTQKAILPMRLLFNDFIQSMSNVDN--.....LGGENPKENFLLIRSKVLELSTRVQVVADDFNKLQPLFETISEYST--KHGDKKYQPLETL..........................KSFS...P.NG..GAITNN..V.LS..GA....NVNGIAANINSTS-.-VES..STKK..Y..N...RSNNG----T................................PINAST.PGSSTPTS...AVP.P----...--AKKPR.KP..RQSKK..................AIA-ANS.KN-...---------Q..............................THPSA....ISGTP.--AAN.........GM-GSTP.....NASM-PVISV.PPTNMMASpPLSA.........MMSPMA.PANFA.AT.PQSQA.Q..S.QPQ.QQPQQQ....-----.........------.---------..............--------------------...----------..-----.......------...----......----...--.-.-----.-------------------p....................................................
MED3_CANGA/13-481 .............................DVLTPSMSLTELEMKFADETD..........GKAKDVVQARIKKAEDGILPLRLQFNDFTQIMSSLDEER.....YANVSKQEKFQMIRSKVLGLTERLQELSNDFEELQPLFATVGEYSKTYKNKN--FQVLENL..........................ASYN...H.RG..KA---G..A.SI..SN....STPTPAAATPTTAP.TPGA..GTKK..A..A...KTAPTPTATA................................TIGTPS.--NNAPTP...ATT.ATTPG...TQAKKPR.KP..RQTKKqq.............qaaAAAAAVA.QAQ...AQAQAQAQNQnqnnmqnknisnpgmnsnmgtpvmgnpnmkQMQSP....IPANA.MNNMNvp....hngAMRPSVPngnmgNPSMGNLNMN.APN--MGN.PNMNnpnmnnpnaMMSPMAgQGQLN.QM.FPMQN.H..N.QNG.QFMGQQ....SPGPNigq...mqfPPNNGN.MNGMPGTSDmnlgmnpsmnmnmgMNLNQITPANILSMNTKGKDdqmQNIGMDQNQN..QNQSQ.......NQSQNQ..nQSMN......MNMN...ND.S.NNPKSaYDLVDFNSLDLSSLNMDFL.....................................................
MED3_EREGS/7-199 ............................g-ILRENLTLEELQEWLTSSEG..........--NKLAIDDHIKATQGRVLPLRLLFNEFLRTISHIEQ--.....LSDKTPQEKFQLIRSKLQELYGKLHALVRDFQRLQPLFDTMVPFSET---SERKFYPKETL..........................GTAV...E.PV..RPLASP..S.YR..RP....SNRSSADTPSSNAP.TPSA..AVVS..G..A...ALVA-PQ---................................------.--------...---.-----...-------.--..-----..................-------.---...----------..............................-----....-----.-----.........-------.....----------.--------.----.........------.-----.--.-----.-..-.---.------....-----.........------.---------..............--------------------...----------..-----.......------...----......----...--.-.-----.-------------------vkhqrrprtntakrqpsvsasvvpsanssgp......................
A0A1G4JCG7_9SACH/2-384 .........................tdns--------VKEMETRFAQEDG..........-LQTE-LVREFQAPKGLIMPLRLQFNDLLNTMATIDQ--.....NKGKSAHENFQMVRAKVIALNSQIQEFSRQVKGLEPRFESLEKYAT--EMKTSKFAPLETL..........................SRSS...E.A-..AAV-QQ..S.KN..VS....GISG-LSGGPSVAS.GP--..SPAS..A..A...ARASY----S................................SANTPN.SSVSTPSG...AQ-.----G...AAARKPK.RS..RAKKNsvsgsmpgsmpsgmssgmPGSVPGT.QPL...QQMSLAPQQP..............................QQQQH....HQM--.--PMP.........S-----A.....NPGQ-ILANM.SPANMMSS.P-MN.........VISPMN.TGLSG.VM.GSSF-.-..-.SSN.SMMTSA....NKPQT.........--APQQ.RQAVPTPQQ..............INMSNITPANILTMSMMDKN...MNNPAIRSQP..QQQPA.......QQPQPQ...QQQQptpqprTQTQ...QLpQ.VGSND.FTNLDLNNLDLSNLNMDF-f....................................................
B4UMX1_CANGA/13-477 .............................DVLTPSMSLTELEMKFADETD..........GKAKDVVQARIKKAEDGILPLRLQFNDFTQIMSSLDEER.....YANVSKQEKFQMIRSKVLGLTERLQELSNDFEELQPLFATVGEYSKTYKNKN--FQVLENL..........................ASYN...H.RG..KA---G..A.SI..SN....STPTPAAATPTTAP.TPGA..GTKK..A..A...KTAPTPTATA................................TIGTPS.--NNAPTP...ATT.ATTPG...TQAKKPR.KP..RQTKKqq.............qaaAAAAAVA.QAQ...AQAQAQAQNQnqnnmqnknisnpgmnsnmgtpvmgnpnmkQMQSP....IPANA.MNNMNvp....hngAMRPSVPngnmgNPSMGNLNMN.APN--MGN.PNMNnpnmnnpnaMMSPMAgQGQLN.QM.FPMQN.H..N.QNG.HFMGQQ....SPGPNigq...mqfPPNNGN.MNGMPGTSDmnlgmnpsmnmnmgMNMNQITPANILSMNTKGKDdqmQNIGMDQNQN..QNQNQ.......NQN---...QSMN......MNMN...ND.S.NNPKSaYDLVDFNSLDLSSLNMDFL.....................................................
J4WEV1_BEAB2/710-868 ............endqsfrrkrrtdgkvk---------------------..........---------------------------------------.....-------------------------------------------------------------..........................----...-.--..------..-.--..--....--------------.---A..NTKN..L.dT...SEVPIPTTIE................................ELSPPVrTHRSSSWG...PVA.ATSPS...EEQRSPR.NG..NSNHD..................AQSQAQQ.QQQ...QQQHQHQQQQqy..........................qqQQQQQ....IAQNGdFDSFD.........SM-SSFP....gDPSAMVM---.--------.----.........------.-----.--.-----.-..-.---.------....-----.........------.---------..............--------------------...----------..-----.......------...----......----...--.-.-----.-------------------dppfpqpllpqdlfalpmtldwnwaemsggayp....................
I2GX35_TETBL/12-175 ............................a-LLPKDCNISKLESSLAANPA..........--SHEALQRQLSQMQQQVLPLRLLFNNLLSILSGTND--.....-TIADNEIYYSTVREMVVEISQQLQNISGNMAQLEPILSTVRSYNQ-EPNRSSFSQLLQNL..........................SETKslsQ.KF..PQPIMT..T.AS..SN....KRSKSQAATPISS-.----..-TSN..Q..-...----------................................------.--------...---.-----...-------.--..-----..................-------.---...----------..............................-----....-----.-----.........-------.....----------.--------.----.........------.-----.--.-----.-..-.---.------....-----.........------.---------..............--------------------...----------..-----.......------...----......----...--.-.-----.-------------------nvnlssvapap..........................................
A0A1G4MBB3_LACFM/8-167 ..........................qav-----RLKMEEMEDKLGSD--..........SMYKDSVLQDIRKAKDSILPMRLRFNDLINTIASIDK--.....TQGKSSQEKFTMIRAKVLELSTEIQSFCGEYHKLQPVFEAMQQYSKEGK-TSKKFTPLETLrh.....................vneVTIN...T.QS..K-----..-.--..--....---PPNATSPSNAR.LNKS..NVNT..P..A...SNVPTPSA--................................------.--------...---.-----...-------.--..-----..................-------.---...----------..............................-----....-----.-----.........-------.....----------.--------.----.........------.-----.--.-----.-..-.---.------....-----.........------.---------..............--------------------...----------..-----.......------...----......----...--.-.-----.-------------------ggnv.................................................
J8LNQ4_SACAR/3-398 .............................SIIPADTKLEDLEVKLAKNEN..........-ETRDNVCKQINEARNEILPLRLQFNEFIQSMANIDHDG.....TKQGDRMVKYLHIRDSILQLNDRFQSLSSHLETLQPLFNTVPEYLRTADNKDRSFQLLEPL..........................STYN...Q.NG..TVTGPA..A.AV..AN....TSHSTAASTPTTT-.-PHA..NSNA..H..T...HSLSNPNTTTammqqnpma..............gkrgpkgstTIGTPN.---SAAAA...ATA.A----...--AKKPR.KP..RQTKK..................AKAQAQA.QAQ...AQAQAQAQAQaqvy......................ahpsAVQTP....ITA--.-----.........SMTAALP.....NPTPNIINSV.SPTNVMGT.PLTN.........MMSPMT.-----.NA.YSMVA.P..N.QGG.QPAMSQftnhSNGTN.........PNPTTN.ANNTPLQSQ..............LNLNNLTPANILNMS-----...MNNDFQQQQQ..QQQQP.......QQPQQQ...Q---......YNMN...TM.N.NNGKE.LDSLDLNNLELGGLNMDFL.....................................................
J6EII9_SACK1/3-412 .............................SIIAADVKLEDLEVALAKNEN..........-ETRDNVCKEISEARDEILPLRLQFNEFIQTMASIDKDG.....PKQGSRMARYLQVRDKILQLNGRFQSLSSHLEALQPLFSTVPEYLKTADNKDRSFQLLEPL..........................STYN...Q.NG..TVAGPA..A.AV..VN....TSHSTAASTPTTT-.TPHA..NPIA..HahA...HSLSQPNSMAtmqqhsla...............gkrghkgssSIGTPN.APNSTVAA...ATA.A----...--TKKPR.KP..RQTKKaka............qaqAQAQAQA.QAQ...AQAQVYSQQS..............................AVQTP....ITA--.-----.........SMAAALP.....NPTPNMINSV.SPTNVMGT.PLTN.........MMSPMA.-----.NG.YSWGG.Q..T.QGGgQPGMPQfnnnGNGTN.........PNPSTN.SNNTPLQSQ..............LNLNNLTPANILNMS-----...MNTDFQQQQQ..PQQPQqpqqqlpQQPQQQ...YNMN......MGMN...TM.N.NNGKE.LDSLDLNNLELGGLNMDFL.....................................................
C5DHV2_LACTC/14-351 ......................kefdfgn-----------LHEKLESED-..........-GYKDSVKQEIQSVQDSIQPMRLRFNELLNMLAIIDQ--.....ETEVSNQEKFLSIRAKIVEFVSELQAFSSSYGRLQPLFDNIQQQPKGGKTSI-KFTPLERLr........................hLSDA...S.LG..NQAKS-..A.SG..GS....PPAAAVASVPTTTK.QPKS..STNT..P..T...SNAATPSATF................................NA----.--------...---.-----...-AAKKSR.KS..RSKKNslptg.......lgghpvATAASPA.AVA...AAAAAVSTN-..............................-PGVA....MGSNP.GIQQQ.........-F---TPs...tNPTQ-ILSSM.SPMNMMSS.P-MN.........IMSPAN.--NVN.MA.YTGPT.K..-.---.------....-----.........PP-VPS.HRHMPSSSQ.............qMNMNGITPANILNMS-----...MMEQANQPHL..TTAPA.......PQP---...-PNQ......LDMN...--.-.-N---.---LDLNNLDLSNLNMDFL.....................................................
C5E049_ZYGRC/9-147 ............................e-ILSINMKLDELESKLSSGDS..........--SKESVMGAINETKGSILPMRLKFNDFLQTMSSIDK--.....MQEVSPDEKFLLIKSKLLELTNSMQQVSEEFTKLQPLFDTVPEYAERYGNKR--YLPLETL.........................rSATN...G.NG..ND-FS-..-.--..--....--------------.----..----..-..-...----------................................------.--------...---.-----...-------.--..-----..................-------.---...----------..............................-----....-----.-----.........-------.....----------.--------.----.........------.-----.--.-----.-..-.---.------....-----.........------.---------..............--------------------...----------..-----.......------...----......----...--.-.-----.-------------------aqqlnqpnqqip.........................................
G8ZWS1_TORDE/124-323 ................pqsnsvsspqtqn---------------------..........---------------------------------------.....-------------------------------------------------------------..........................----...-.--..------..-.--..--....--------------.----..-NAI..V..G...ANLNKKANRS................................NDGTPV.SQTSTPMG...SAV.PTPYA...TTAKKPR.KP..RQPKKpq..............tpA----AA.AAA...AAVAANGHIK..............................SQASP....TPP--.----A.........HMVSSVPa...tNPVQ-MVNSV.PPTNMMGT.PMQN.........LMSPLG.-NTPN.YG.FSQQQ.S..Q.QQ-.PTPQQQ....Q-RQQ.........YNSATK.NSTMPQSQP..............MNLNSITPANILSMSMTGDP...----LHQQQQ..QNK--.......------...----......----...--.-.-----.-------------------ke...................................................
G8ZWS1_TORDE/6-173 .............................DLLVPDMKLEELETSLATGGD..........-DPKDRVDKAITDAQNSILPMRLQFNDFMHTMSNIDD--.....LQNSTPMEKFNLIRSKVLDLSDKLQTMSEDVGKLHPLFDTIPEYSE--KYGTKKFQPLETLripqsn..............svsspqTQNN...AiVG..ANLNKK..AnRS..ND....GTPVSQTSTPMGSA.VP--..----..-..-...----------................................------.--------...---.-----...-------.--..-----..................-------.---...----------..............................-----....-----.-----.........-------.....----------.--------.----.........------.-----.--.-----.-..-.---.------....-----.........------.---------..............--------------------...----------..-----.......------...----......----...--.-.-----.-------------------tpya.................................................
G8JM86_ERECY/6-201 .............................EILSAKLTLEELKEKLANNDE..........--SKSAISGQIQLVKHNVLPLRLSFNDFLKTMSQIEH--.....LNDKSPQEKFLLIRAKVLELYGKLKELVRDFQKLMPLLDTMAVFSE--SNE-QKFYPLETLn........................lLPDP...I.KS..TASPSY..K.KA..VNksnaETPSSNAATPSAA-.----..-LSS..N..N...VVLVGPQAKNqrr.........................prtnNKRQPS.---GTASA...APS.A----...-------.--..-----..................-------.---...----------..............................-----....-----.-----.........-------.....----------.--------.----.........------.-----.--.-----.-..-.---.------....-----.........------.---------..............--------------------...----------..-----.......------...----......----...--.-.-----.-------------------gsagsapi.............................................
A0A0C7N4X0_9SACH/16-361 ...............skshsvdkvferlg-----------------SD--..........DSYKDSVKQELQHVQDSILPMRLKFNELLSTLAAIDR--.....KGESSSAETFNQIRTKLLEFISGVQQFSSDYGKLQPLFERLQEVSKSEDTI-VNFVPLERL..........................SRLN...D.AS..TT-ASG..G.KI..SN....GNSPSANFVSTGKQ.AP-S..NAQT..P..L...SNVPT-----................................----PS.--------...-SV.D---N...APAKKPR.KP..RAKKT..................AGPSPSSiAPQ...QQQQQKQQPQ..............................QHQQP....QPPQ-.----Q.........HFT-PAT.....NPSQ-ILQSM.SPMNMMSS.P-MN.........TISPMNnAAPIS.QIpFSAPS.K..P.P--.--MQQQ....QRH--.........------.VQQTP-QQQ..............FNLDSITPANILHMS-MSDH...GNTPHAQQTNsqQQQQQ.......QQPQPQ...QQ--......QQHL...QS.S.NQ--D.FSALDINNIDLSSLNMDFL.....................................................
A0A507AUA6_9PEZI/371-642 .....................vliddlka---------------------..........---------------------------------------.....---------------------------------DDDVVKKIEEYQK-EKEEARKAEQEKPK..........................SPVA...D.KA..SPVAET..D.TK..SN....GQQEKRESAKSSK-.SPTP..PPAS..A..A...ASAKSPSAEP................................S-AKPA.ANNATGTP...AAT.DGDSQ...SSKKRPAeEP..AENPK..................VPKAPKA.MQQ...QQQE-AQQQQ..............................MMQHM....MNS-M.MPGMNgmggmpgmpGM-PMMP.....FGGMPMMNNF.PP---MGM.PNMNmn.....mgMMNPMM.NPMMGmPN.FGNNG.M..N.GGG.GFGPGN....NNGMGggwgmsgggPPMNGGpMNGG-YNQQ..............FNNNN---------------...----------..-----.......------...----......----...--.-.-----.-------------------ggggnkmmggnfgqq......................................
A0A1X7R5Q2_9SACH/18-394 .............................SILTLHMKLEELERRLAQNPQ..........--GKEQLALTLSTTRESILPIRLELNNFIHMVSNIAD-D.....KNGITNQEKFHNVRTMLLKLHTSIQSLSQRFQELSPLFGTVPEYTTEYKSKE--YQPLETLtptnipq............tpavndpSNKA...T.SG..NTATSN..T.TA..TN....TNNITSTGAPATTT.TTTA..TKKGrgS..A...ASLKSPPTAA................................--NTPT.TGTATPAT...TST.N-AST...TTAKKPR.KP..RQKKS..................VSSAKNT.PAA...THATTTNTNS..............................VVATP....LSATT.MN---.........---PTLS.....VPP-QLMTGM.IPGNIVGM.SPTN.........TMMNMA.----P.QM.QPQMQ.F..N.SNN.-----M....NNRQT.........----GN.TPGPQGQLS..............PQNNTITPANILSMG-----...SNNNITNNSN..LVSNN.......S-----...NNNN......NNNN...NQ.GpNAMND.FGNLDLNNIDLSSLNMDFL.....................................................
A0A0D2MAU2_9CHLO/466-686 .edvgevlsllsevarqpafpearldvtr---------------------..........---------------------------------------.....------------------------------------------------------SQVLENL..........................SHRD...D.VG..SAVARRevR.KL..VL....GADSPWARTPTTKG.VASI..SRQD..L..QefwAAWERPDA-A................................VLGIVG.DFNPATLE...AQI.RGAFGdwaPAPGQPQ.AP..RTAPEgr.............alvSQAAGLA.EQQ...QQQQQQQQQQ..............................QQQDP....QGAGA.EAG--.........-------.....----------.--------.----.........------.-----.--.-----.-..-.---.------....-----.........------.---------..............--------------------...----------..-----.......------...----......----...--.-.-----.-------------------lglrrvlgaassapppaakltrakqeklnsfvfnfatpsaqlqraaayellgi
H2AZT1_KAZAF/9-257 .............................EVLTLTVKLEELETKFATNEN..........--SKQSVLDLVNETRSLILPIRLQLNEFISLMANIDK--.....MTETSNIDKYNHIRKSLLTLQNNIQTLSQNFVKLNPLFNTIPEYST--KHNSREFKPLESL..........................SNDP..fA.KG..SP--RT..T.SS..GS....ANNTITSATSITT-.--NA..NNKI..S..A...ATPS-----S................................NINTPA.----SSSQ...NIT.NTTPS...--IKKPR.KP..RQPRK..................SITQTNT.ANK...AS---KTTTP..............................SAPTP....VAA-P.MQTPG.........TMNPALPv...qN-----FNTK.TPIN-LGS.PNGP.........------.-----.--.-----.-..-.---.------....-----.........------.---------..............--------------------...----------..-----.......------...----......----...--.-.-----.-------------------qfspp................................................
A0A1E5RAI1_9ASCO/25-471 dlqslqkylleqvpqsepnnksasasial---------------------..........-------NGYMAKVQNEILPLRLEFNALLKQMAHLDN--.....-PQESGKQKYLALKARLVTVTTKINDLSQEFKKLQPLLYILKNNQKILETPN-SYYILETLdqlpqpeikvplpkqfqpkiintlpnAVSN...S.TGvnTAVSSA..Q.KAtkSP....VNSVNSPSTPATAK.TPGSvaASNT..V..K...HSLQGNLASA................................STFSG-.IRKNAKGS...GAN.AHASS...GSVKKPA.TNskRGTPQ..................AFSPLSA.NTP...VTNVSASNNStnlsnigavy.........nsggrsknhdqVTSAP...lSKANS.ANESP.........SMYMNTS.....NITPANILQN.LNS-SMGN.N--S.........QSSNMG.ALSSR.VG.M----.N..G.PSG.NIGQQR....VN--N.........PNSNSN.SNNINNNSMn...........ygNNMNNRVPSTDNSMGGYGYN...GNFSMSPSSI..LQNMN.......NLPNNNssvASGN......MSPNgslNT.N.NN--S.AGMLDLNTLDLSNLD-DFL.....................................................
A0A1G4JS46_9SACH/11-346 ........................nearp--------LENLFERLGSDHE..........--FKNSIKQELQNVQNSILPMRLHFNELLNAMASIDA--.....KQESSALERFTYVRTKLLEFMKDVDTLSSDYVRLQPLFDGLQQASK-DDNISVKFSPLERL..........................SNIN...D.AA..LA---T..A.GR..PQ....SGKRSNVNSPSAL-.-AAA..STTK..S..A...VSSGN-----................................---TPS.--SNLPTP...STT.A---S...AAAKKPR.KP..RTKKNs...............gpSPSSMPS.QPQ...PPSQALQQAI..............................HQQQP....AQS--.MQHQK.........QFTPS-T.....NPSQ-LLSGM.SPMNIMSS.PL-N.........TMSPVN.----G.SN.MSFPP.G..G.KPS.NMHSVQ....-----.........------.RHVQPSQPS..............FNSNSITPANILSMSM--S-...-----DQSNP..A---A.......AYT---...----......-QMN...PQ.G.SVNQD.LGSLDLNNIDLSNLNMDFL.....................................................
A0A2N6NMW4_BEABA/656-813 ............endqsfrrkrrtdgkvk---------------------..........---------------------------------------.....-------------------------------------------------------------..........................----...-.--..------..-.--..--....--------------.---A..NTKN..L.dT...SEVPIPTTIE................................ELSPPVrTHRSSSWG...PVA.ATSPS...EEQRSPR.NG..NPNND..................AQSQAQQ.QQQ...QQQQQQQQQQy...........................qqQQQQH....VAQNGdFDSFD.........GM-SSFP....gDPSAMV----.--------.----.........------.-----.--.-----.-..-.---.------....-----.........------.---------..............--------------------...----------..-----.......------...----......----...--.-.-----.-------------------mdppfpqpllpqdlftlpmtldwnwaemsggayp...................
MED3_KLULA/8-229 ......................qifkdnl-------TFDTFRELIIEKE-..........-STADEVADKVLEAKKALLPIRTLMTEFVGMIANLES--.....MGNKTSQEKFLAIRMKLIELQNNIQKFSKDFQQLQPVMRTMDKFNEEVNAGEKKFFVQETLg........................yTQLA...S.NG..SAAGIT..K.TS..SG....NDGNTTGSTANTM-.AMAK..GLKK..N..A...AGKPN-TGTGvqsgpgrrn..............stkktghtgPATAPT.TSNSAASA...AAA.AANTP...SL-----.--..-----..................-------.---...----------..............................-----....-----.-----.........-------.....----------.--------.----.........------.-----.--.-----.-..-.---.------....-----.........------.---------..............--------------------...----------..-----.......------...----......----...--.-.-----.-------------------kqipntqpmql..........................................
A0A0A2VVG2_BEABA/145-309 .........ekaendqsfrrkrrtdgkvk---------------------..........---------------------------------------.....-------------------------------------------------------------..........................----...-.--..------..-.--..--....--------------.---A..NTKN..L.dT...SEVPIPTTIE................................ELSPPVrTHRSSSWG...PVA.ATSPS...EEQRSPR.NG..NPNHD..................AQSQAQQ.QQQ...QQQHQHQQQQqy..........................qqQQQQQ....IAQNGdFDSFD.........SM-SSFP....gDPSAMVM---.--------.----.........------.-----.--.-----.-..-.---.------....-----.........------.---------..............--------------------...----------..-----.......------...----......----...--.-.-----.-------------------dppfpqpllpqdlfalpmtldwnwaemsggaypsve.................
#=GC SS_cons .............................-SS-TT--HHHHHHHHTSGGG..........-HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHTTTSS-.....-SHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHSHHHHTHHHHHHHHH-XXXXXXXXXXXX..........................XXXX...X.XX..XXXXXX..X.XX..XX....XXXXXXXXXXXXXX.XXXX..XXXX..X..X...XXXXXXXXXXXXXXXXXX...............XXXXXXXXXXXXXXX.XXXXXXXX...XXX.X----...--XXXXX.XX..XXXXX..................XXXXXXX.XXX...XXXXXXXXXX..............................XXXXX....XXX--.-----.........XXXXXXX.....XXXXXXXXXX.XXXXXXXX.XXXX.........XXXXXX.-----.XX.XXXXX.X..X.XXX.XXXXXXXXXXXXXXX.........XXXXXX.XXXXXXXXX..............XXXXXXXXXXXXXXX-----...XXXXXXXXXX..XXXXX.......XXXXXX...XXXX......XXXX...XX.X.XXXXX.XXXXXXXXXXXXXXXXXXX.....................................................
#=GC seq_cons ....................................plppLc.phstp..............s+ptlhttlppspppILPhRLpFN-hlphhusl-p........tptos.-+F.hlRs+llpL.splQphSpchppLpPLFpsl.pasc..pstp.papsLEsL..........................sshs...p.pu..ss...t..t.t...ss....ss.ssssssssst...stu..sstp.....s...sshst......................................hssss...tsss.s...sss.s..........+pP+.ps..pttpp..................s.s...t.t......t.t...p..................................tt..........................h....s.....ss....h...........................................................................................................................................................................................................................................................................
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